Diff for /imach/src/imach.c between versions 1.18 and 1.107

version 1.18, 2002/02/20 17:17:09 version 1.107, 2006/01/19 16:20:37
Line 1 Line 1
      /* $Id$
 /*********************** Imach **************************************            $State$
   This program computes Healthy Life Expectancies from cross-longitudinal    $Log$
   data. Cross-longitudinal consist in a first survey ("cross") where    Revision 1.107  2006/01/19 16:20:37  brouard
   individuals from different ages are interviewed on their health status    Test existence of gnuplot in imach path
   or degree of  disability. At least a second wave of interviews  
   ("longitudinal") should  measure each new individual health status.    Revision 1.106  2006/01/19 13:24:36  brouard
   Health expectancies are computed from the transistions observed between    Some cleaning and links added in html output
   waves and are computed for each degree of severity of disability (number  
   of life states). More degrees you consider, more time is necessary to    Revision 1.105  2006/01/05 20:23:19  lievre
   reach the Maximum Likelihood of the parameters involved in the model.    *** empty log message ***
   The simplest model is the multinomial logistic model where pij is  
   the probabibility to be observed in state j at the second wave conditional    Revision 1.104  2005/09/30 16:11:43  lievre
   to be observed in state i at the first wave. Therefore the model is:    (Module): sump fixed, loop imx fixed, and simplifications.
   log(pij/pii)= aij + bij*age+ cij*sex + etc , where 'age' is age and 'sex'    (Module): If the status is missing at the last wave but we know
   is a covariate. If you want to have a more complex model than "constant and    that the person is alive, then we can code his/her status as -2
   age", you should modify the program where the markup    (instead of missing=-1 in earlier versions) and his/her
     *Covariates have to be included here again* invites you to do it.    contributions to the likelihood is 1 - Prob of dying from last
   More covariates you add, less is the speed of the convergence.    health status (= 1-p13= p11+p12 in the easiest case of somebody in
     the healthy state at last known wave). Version is 0.98
   The advantage that this computer programme claims, comes from that if the  
   delay between waves is not identical for each individual, or if some    Revision 1.103  2005/09/30 15:54:49  lievre
   individual missed an interview, the information is not rounded or lost, but    (Module): sump fixed, loop imx fixed, and simplifications.
   taken into account using an interpolation or extrapolation.  
   hPijx is the probability to be    Revision 1.102  2004/09/15 17:31:30  brouard
   observed in state i at age x+h conditional to the observed state i at age    Add the possibility to read data file including tab characters.
   x. The delay 'h' can be split into an exact number (nh*stepm) of  
   unobserved intermediate  states. This elementary transition (by month or    Revision 1.101  2004/09/15 10:38:38  brouard
   quarter trimester, semester or year) is model as a multinomial logistic.    Fix on curr_time
   The hPx matrix is simply the matrix product of nh*stepm elementary matrices  
   and the contribution of each individual to the likelihood is simply hPijx.    Revision 1.100  2004/07/12 18:29:06  brouard
     Add version for Mac OS X. Just define UNIX in Makefile
   Also this programme outputs the covariance matrix of the parameters but also  
   of the life expectancies. It also computes the prevalence limits.    Revision 1.99  2004/06/05 08:57:40  brouard
      *** empty log message ***
   Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).  
            Institut national d'études démographiques, Paris.    Revision 1.98  2004/05/16 15:05:56  brouard
   This software have been partly granted by Euro-REVES, a concerted action    New version 0.97 . First attempt to estimate force of mortality
   from the European Union.    directly from the data i.e. without the need of knowing the health
   It is copyrighted identically to a GNU software product, ie programme and    state at each age, but using a Gompertz model: log u =a + b*age .
   software can be distributed freely for non commercial use. Latest version    This is the basic analysis of mortality and should be done before any
   can be accessed at http://euroreves.ined.fr/imach .    other analysis, in order to test if the mortality estimated from the
   **********************************************************************/    cross-longitudinal survey is different from the mortality estimated
      from other sources like vital statistic data.
 #include <math.h>  
 #include <stdio.h>    The same imach parameter file can be used but the option for mle should be -3.
 #include <stdlib.h>  
 #include <unistd.h>    Agnès, who wrote this part of the code, tried to keep most of the
     former routines in order to include the new code within the former code.
 #define MAXLINE 256  
 #define FILENAMELENGTH 80    The output is very simple: only an estimate of the intercept and of
 /*#define DEBUG*/    the slope with 95% confident intervals.
 #define windows  
 #define GLOCK_ERROR_NOPATH              -1      /* empty path */    Current limitations:
 #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */    A) Even if you enter covariates, i.e. with the
     model= V1+V2 equation for example, the programm does only estimate a unique global model without covariates.
 #define MAXPARM 30 /* Maximum number of parameters for the optimization */    B) There is no computation of Life Expectancy nor Life Table.
 #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */  
     Revision 1.97  2004/02/20 13:25:42  lievre
 #define NINTERVMAX 8    Version 0.96d. Population forecasting command line is (temporarily)
 #define NLSTATEMAX 8 /* Maximum number of live states (for func) */    suppressed.
 #define NDEATHMAX 8 /* Maximum number of dead states (for func) */  
 #define NCOVMAX 8 /* Maximum number of covariates */    Revision 1.96  2003/07/15 15:38:55  brouard
 #define MAXN 20000    * imach.c (Repository): Errors in subdirf, 2, 3 while printing tmpout is
 #define YEARM 12. /* Number of months per year */    rewritten within the same printf. Workaround: many printfs.
 #define AGESUP 130  
 #define AGEBASE 40    Revision 1.95  2003/07/08 07:54:34  brouard
     * imach.c (Repository):
     (Repository): Using imachwizard code to output a more meaningful covariance
 int nvar;    matrix (cov(a12,c31) instead of numbers.
 int cptcovn, cptcovage=0, cptcoveff=0,cptcov;  
 int npar=NPARMAX;    Revision 1.94  2003/06/27 13:00:02  brouard
 int nlstate=2; /* Number of live states */    Just cleaning
 int ndeath=1; /* Number of dead states */  
 int ncovmodel, ncov;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */    Revision 1.93  2003/06/25 16:33:55  brouard
 int popbased=0;    (Module): On windows (cygwin) function asctime_r doesn't
     exist so I changed back to asctime which exists.
 int *wav; /* Number of waves for this individuual 0 is possible */    (Module): Version 0.96b
 int maxwav; /* Maxim number of waves */  
 int jmin, jmax; /* min, max spacing between 2 waves */    Revision 1.92  2003/06/25 16:30:45  brouard
 int mle, weightopt;    (Module): On windows (cygwin) function asctime_r doesn't
 int **mw; /* mw[mi][i] is number of the mi wave for this individual */    exist so I changed back to asctime which exists.
 int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */  
 double jmean; /* Mean space between 2 waves */    Revision 1.91  2003/06/25 15:30:29  brouard
 double **oldm, **newm, **savm; /* Working pointers to matrices */    * imach.c (Repository): Duplicated warning errors corrected.
 double **oldms, **newms, **savms; /* Fixed working pointers to matrices */    (Repository): Elapsed time after each iteration is now output. It
 FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest,*ficresf;    helps to forecast when convergence will be reached. Elapsed time
 FILE *ficgp, *fichtm,*ficresprob,*ficpop;    is stamped in powell.  We created a new html file for the graphs
 FILE *ficreseij;    concerning matrix of covariance. It has extension -cov.htm.
   char filerese[FILENAMELENGTH];  
  FILE  *ficresvij;    Revision 1.90  2003/06/24 12:34:15  brouard
   char fileresv[FILENAMELENGTH];    (Module): Some bugs corrected for windows. Also, when
  FILE  *ficresvpl;    mle=-1 a template is output in file "or"mypar.txt with the design
   char fileresvpl[FILENAMELENGTH];    of the covariance matrix to be input.
   
 #define NR_END 1    Revision 1.89  2003/06/24 12:30:52  brouard
 #define FREE_ARG char*    (Module): Some bugs corrected for windows. Also, when
 #define FTOL 1.0e-10    mle=-1 a template is output in file "or"mypar.txt with the design
     of the covariance matrix to be input.
 #define NRANSI  
 #define ITMAX 200    Revision 1.88  2003/06/23 17:54:56  brouard
     * imach.c (Repository): Create a sub-directory where all the secondary files are. Only imach, htm, gp and r(imach) are on the main directory. Correct time and other things.
 #define TOL 2.0e-4  
     Revision 1.87  2003/06/18 12:26:01  brouard
 #define CGOLD 0.3819660    Version 0.96
 #define ZEPS 1.0e-10  
 #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d);    Revision 1.86  2003/06/17 20:04:08  brouard
     (Module): Change position of html and gnuplot routines and added
 #define GOLD 1.618034    routine fileappend.
 #define GLIMIT 100.0  
 #define TINY 1.0e-20    Revision 1.85  2003/06/17 13:12:43  brouard
     * imach.c (Repository): Check when date of death was earlier that
 static double maxarg1,maxarg2;    current date of interview. It may happen when the death was just
 #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))    prior to the death. In this case, dh was negative and likelihood
 #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))    was wrong (infinity). We still send an "Error" but patch by
      assuming that the date of death was just one stepm after the
 #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))    interview.
 #define rint(a) floor(a+0.5)    (Repository): Because some people have very long ID (first column)
     we changed int to long in num[] and we added a new lvector for
 static double sqrarg;    memory allocation. But we also truncated to 8 characters (left
 #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)    truncation)
 #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;}    (Repository): No more line truncation errors.
   
 int imx;    Revision 1.84  2003/06/13 21:44:43  brouard
 int stepm;    * imach.c (Repository): Replace "freqsummary" at a correct
 /* Stepm, step in month: minimum step interpolation*/    place. It differs from routine "prevalence" which may be called
     many times. Probs is memory consuming and must be used with
 int m,nb;    parcimony.
 int *num, firstpass=0, lastpass=4,*cod, *ncodemax, *Tage;    Version 0.95a3 (should output exactly the same maximization than 0.8a2)
 double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;  
 double **pmmij, ***probs, ***mobaverage;    Revision 1.83  2003/06/10 13:39:11  lievre
     *** empty log message ***
 double *weight;  
 int **s; /* Status */    Revision 1.82  2003/06/05 15:57:20  brouard
 double *agedc, **covar, idx;    Add log in  imach.c and  fullversion number is now printed.
 int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;  
   */
 double ftol=FTOL; /* Tolerance for computing Max Likelihood */  /*
 double ftolhess; /* Tolerance for computing hessian */     Interpolated Markov Chain
   
 /**************** split *************************/    Short summary of the programme:
 static  int split( char *path, char *dirc, char *name )    
 {    This program computes Healthy Life Expectancies from
    char *s;                             /* pointer */    cross-longitudinal data. Cross-longitudinal data consist in: -1- a
    int  l1, l2;                         /* length counters */    first survey ("cross") where individuals from different ages are
     interviewed on their health status or degree of disability (in the
    l1 = strlen( path );                 /* length of path */    case of a health survey which is our main interest) -2- at least a
    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );    second wave of interviews ("longitudinal") which measure each change
    s = strrchr( path, '\\' );           /* find last / */    (if any) in individual health status.  Health expectancies are
    if ( s == NULL ) {                   /* no directory, so use current */    computed from the time spent in each health state according to a
 #if     defined(__bsd__)                /* get current working directory */    model. More health states you consider, more time is necessary to reach the
       extern char       *getwd( );    Maximum Likelihood of the parameters involved in the model.  The
     simplest model is the multinomial logistic model where pij is the
       if ( getwd( dirc ) == NULL ) {    probability to be observed in state j at the second wave
 #else    conditional to be observed in state i at the first wave. Therefore
       extern char       *getcwd( );    the model is: log(pij/pii)= aij + bij*age+ cij*sex + etc , where
     'age' is age and 'sex' is a covariate. If you want to have a more
       if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {    complex model than "constant and age", you should modify the program
 #endif    where the markup *Covariates have to be included here again* invites
          return( GLOCK_ERROR_GETCWD );    you to do it.  More covariates you add, slower the
       }    convergence.
       strcpy( name, path );             /* we've got it */  
    } else {                             /* strip direcotry from path */    The advantage of this computer programme, compared to a simple
       s++;                              /* after this, the filename */    multinomial logistic model, is clear when the delay between waves is not
       l2 = strlen( s );                 /* length of filename */    identical for each individual. Also, if a individual missed an
       if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );    intermediate interview, the information is lost, but taken into
       strcpy( name, s );                /* save file name */    account using an interpolation or extrapolation.  
       strncpy( dirc, path, l1 - l2 );   /* now the directory */  
       dirc[l1-l2] = 0;                  /* add zero */    hPijx is the probability to be observed in state i at age x+h
    }    conditional to the observed state i at age x. The delay 'h' can be
    l1 = strlen( dirc );                 /* length of directory */    split into an exact number (nh*stepm) of unobserved intermediate
    if ( dirc[l1-1] != '\\' ) { dirc[l1] = '\\'; dirc[l1+1] = 0; }    states. This elementary transition (by month, quarter,
    return( 0 );                         /* we're done */    semester or year) is modelled as a multinomial logistic.  The hPx
 }    matrix is simply the matrix product of nh*stepm elementary matrices
     and the contribution of each individual to the likelihood is simply
     hPijx.
 /******************************************/  
     Also this programme outputs the covariance matrix of the parameters but also
 void replace(char *s, char*t)    of the life expectancies. It also computes the stable prevalence. 
 {    
   int i;    Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).
   int lg=20;             Institut national d'études démographiques, Paris.
   i=0;    This software have been partly granted by Euro-REVES, a concerted action
   lg=strlen(t);    from the European Union.
   for(i=0; i<= lg; i++) {    It is copyrighted identically to a GNU software product, ie programme and
     (s[i] = t[i]);    software can be distributed freely for non commercial use. Latest version
     if (t[i]== '\\') s[i]='/';    can be accessed at http://euroreves.ined.fr/imach .
   }  
 }    Help to debug: LD_PRELOAD=/usr/local/lib/libnjamd.so ./imach foo.imach
     or better on gdb : set env LD_PRELOAD=/usr/local/lib/libnjamd.so
 int nbocc(char *s, char occ)    
 {    **********************************************************************/
   int i,j=0;  /*
   int lg=20;    main
   i=0;    read parameterfile
   lg=strlen(s);    read datafile
   for(i=0; i<= lg; i++) {    concatwav
   if  (s[i] == occ ) j++;    freqsummary
   }    if (mle >= 1)
   return j;      mlikeli
 }    print results files
     if mle==1 
 void cutv(char *u,char *v, char*t, char occ)       computes hessian
 {    read end of parameter file: agemin, agemax, bage, fage, estepm
   int i,lg,j,p=0;        begin-prev-date,...
   i=0;    open gnuplot file
   for(j=0; j<=strlen(t)-1; j++) {    open html file
     if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;    stable prevalence
   }     for age prevalim()
     h Pij x
   lg=strlen(t);    variance of p varprob
   for(j=0; j<p; j++) {    forecasting if prevfcast==1 prevforecast call prevalence()
     (u[j] = t[j]);    health expectancies
   }    Variance-covariance of DFLE
      u[p]='\0';    prevalence()
      movingaverage()
    for(j=0; j<= lg; j++) {    varevsij() 
     if (j>=(p+1))(v[j-p-1] = t[j]);    if popbased==1 varevsij(,popbased)
   }    total life expectancies
 }    Variance of stable prevalence
    end
 /********************** nrerror ********************/  */
   
 void nrerror(char error_text[])  
 {  
   fprintf(stderr,"ERREUR ...\n");   
   fprintf(stderr,"%s\n",error_text);  #include <math.h>
   exit(1);  #include <stdio.h>
 }  #include <stdlib.h>
 /*********************** vector *******************/  #include <string.h>
 double *vector(int nl, int nh)  #include <unistd.h>
 {  
   double *v;  #include <sys/types.h>
   v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));  #include <sys/stat.h>
   if (!v) nrerror("allocation failure in vector");  #include <errno.h>
   return v-nl+NR_END;  extern int errno;
 }  
   /* #include <sys/time.h> */
 /************************ free vector ******************/  #include <time.h>
 void free_vector(double*v, int nl, int nh)  #include "timeval.h"
 {  
   free((FREE_ARG)(v+nl-NR_END));  /* #include <libintl.h> */
 }  /* #define _(String) gettext (String) */
   
 /************************ivector *******************************/  #define MAXLINE 256
 int *ivector(long nl,long nh)  #define GNUPLOTPROGRAM "gnuplot"
 {  /*#define GNUPLOTPROGRAM "..\\gp37mgw\\wgnuplot"*/
   int *v;  #define FILENAMELENGTH 132
   v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));  /*#define DEBUG*/
   if (!v) nrerror("allocation failure in ivector");  /*#define windows*/
   return v-nl+NR_END;  #define GLOCK_ERROR_NOPATH              -1      /* empty path */
 }  #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */
   
 /******************free ivector **************************/  #define MAXPARM 30 /* Maximum number of parameters for the optimization */
 void free_ivector(int *v, long nl, long nh)  #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */
 {  
   free((FREE_ARG)(v+nl-NR_END));  #define NINTERVMAX 8
 }  #define NLSTATEMAX 8 /* Maximum number of live states (for func) */
   #define NDEATHMAX 8 /* Maximum number of dead states (for func) */
 /******************* imatrix *******************************/  #define NCOVMAX 8 /* Maximum number of covariates */
 int **imatrix(long nrl, long nrh, long ncl, long nch)  #define MAXN 20000
      /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */  #define YEARM 12. /* Number of months per year */
 {  #define AGESUP 130
   long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;  #define AGEBASE 40
   int **m;  #define AGEGOMP 10. /* Minimal age for Gompertz adjustment */
    #ifdef UNIX
   /* allocate pointers to rows */  #define DIRSEPARATOR '/'
   m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*)));  #define CHARSEPARATOR "/"
   if (!m) nrerror("allocation failure 1 in matrix()");  #define ODIRSEPARATOR '\\'
   m += NR_END;  #else
   m -= nrl;  #define DIRSEPARATOR '\\'
    #define CHARSEPARATOR "\\"
    #define ODIRSEPARATOR '/'
   /* allocate rows and set pointers to them */  #endif
   m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int)));  
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  /* $Id$ */
   m[nrl] += NR_END;  /* $State$ */
   m[nrl] -= ncl;  
    char version[]="Imach version 0.98a, January 2006, INED-EUROREVES ";
   for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;  char fullversion[]="$Revision$ $Date$"; 
    int erreur, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings  */
   /* return pointer to array of pointers to rows */  int nvar;
   return m;  int cptcovn=0, cptcovage=0, cptcoveff=0,cptcov;
 }  int npar=NPARMAX;
   int nlstate=2; /* Number of live states */
 /****************** free_imatrix *************************/  int ndeath=1; /* Number of dead states */
 void free_imatrix(m,nrl,nrh,ncl,nch)  int ncovmodel, ncovcol;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */
       int **m;  int popbased=0;
       long nch,ncl,nrh,nrl;  
      /* free an int matrix allocated by imatrix() */  int *wav; /* Number of waves for this individuual 0 is possible */
 {  int maxwav; /* Maxim number of waves */
   free((FREE_ARG) (m[nrl]+ncl-NR_END));  int jmin, jmax; /* min, max spacing between 2 waves */
   free((FREE_ARG) (m+nrl-NR_END));  int gipmx, gsw; /* Global variables on the number of contributions 
 }                     to the likelihood and the sum of weights (done by funcone)*/
   int mle, weightopt;
 /******************* matrix *******************************/  int **mw; /* mw[mi][i] is number of the mi wave for this individual */
 double **matrix(long nrl, long nrh, long ncl, long nch)  int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */
 {  int **bh; /* bh[mi][i] is the bias (+ or -) for this individual if the delay between
   long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;             * wave mi and wave mi+1 is not an exact multiple of stepm. */
   double **m;  double jmean; /* Mean space between 2 waves */
   double **oldm, **newm, **savm; /* Working pointers to matrices */
   m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  double **oldms, **newms, **savms; /* Fixed working pointers to matrices */
   if (!m) nrerror("allocation failure 1 in matrix()");  FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest,*ficresf,*ficrespop;
   m += NR_END;  FILE *ficlog, *ficrespow;
   m -= nrl;  int globpr; /* Global variable for printing or not */
   double fretone; /* Only one call to likelihood */
   m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  long ipmx; /* Number of contributions */
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  double sw; /* Sum of weights */
   m[nrl] += NR_END;  char filerespow[FILENAMELENGTH];
   m[nrl] -= ncl;  char fileresilk[FILENAMELENGTH]; /* File of individual contributions to the likelihood */
   FILE *ficresilk;
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  FILE *ficgp,*ficresprob,*ficpop, *ficresprobcov, *ficresprobcor;
   return m;  FILE *ficresprobmorprev;
 }  FILE *fichtm, *fichtmcov; /* Html File */
   FILE *ficreseij;
 /*************************free matrix ************************/  char filerese[FILENAMELENGTH];
 void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)  FILE  *ficresvij;
 {  char fileresv[FILENAMELENGTH];
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  FILE  *ficresvpl;
   free((FREE_ARG)(m+nrl-NR_END));  char fileresvpl[FILENAMELENGTH];
 }  char title[MAXLINE];
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];
 /******************* ma3x *******************************/  char optionfilext[10], optionfilefiname[FILENAMELENGTH], plotcmd[FILENAMELENGTH];
 double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)  char tmpout[FILENAMELENGTH],  tmpout2[FILENAMELENGTH]; 
 {  char command[FILENAMELENGTH];
   long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;  int  outcmd=0;
   double ***m;  
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], rfileres[FILENAMELENGTH];
   m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  
   if (!m) nrerror("allocation failure 1 in matrix()");  char filelog[FILENAMELENGTH]; /* Log file */
   m += NR_END;  char filerest[FILENAMELENGTH];
   m -= nrl;  char fileregp[FILENAMELENGTH];
   char popfile[FILENAMELENGTH];
   m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  char optionfilegnuplot[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH], optionfilehtmcov[FILENAMELENGTH] ;
   m[nrl] += NR_END;  
   m[nrl] -= ncl;  struct timeval start_time, end_time, curr_time, last_time, forecast_time;
   struct timezone tzp;
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  extern int gettimeofday();
   struct tm tmg, tm, tmf, *gmtime(), *localtime();
   m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));  long time_value;
   if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");  extern long time();
   m[nrl][ncl] += NR_END;  char strcurr[80], strfor[80];
   m[nrl][ncl] -= nll;  
   for (j=ncl+1; j<=nch; j++)  #define NR_END 1
     m[nrl][j]=m[nrl][j-1]+nlay;  #define FREE_ARG char*
    #define FTOL 1.0e-10
   for (i=nrl+1; i<=nrh; i++) {  
     m[i][ncl]=m[i-1l][ncl]+ncol*nlay;  #define NRANSI 
     for (j=ncl+1; j<=nch; j++)  #define ITMAX 200 
       m[i][j]=m[i][j-1]+nlay;  
   }  #define TOL 2.0e-4 
   return m;  
 }  #define CGOLD 0.3819660 
   #define ZEPS 1.0e-10 
 /*************************free ma3x ************************/  #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d); 
 void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)  
 {  #define GOLD 1.618034 
   free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));  #define GLIMIT 100.0 
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  #define TINY 1.0e-20 
   free((FREE_ARG)(m+nrl-NR_END));  
 }  static double maxarg1,maxarg2;
   #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))
 /***************** f1dim *************************/  #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))
 extern int ncom;    
 extern double *pcom,*xicom;  #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))
 extern double (*nrfunc)(double []);  #define rint(a) floor(a+0.5)
    
 double f1dim(double x)  static double sqrarg;
 {  #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)
   int j;  #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;} 
   double f;  int agegomp= AGEGOMP;
   double *xt;  
    int imx; 
   xt=vector(1,ncom);  int stepm=1;
   for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j];  /* Stepm, step in month: minimum step interpolation*/
   f=(*nrfunc)(xt);  
   free_vector(xt,1,ncom);  int estepm;
   return f;  /* Estepm, step in month to interpolate survival function in order to approximate Life Expectancy*/
 }  
   int m,nb;
 /*****************brent *************************/  long *num;
 double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin)  int firstpass=0, lastpass=4,*cod, *ncodemax, *Tage,*cens;
 {  double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;
   int iter;  double **pmmij, ***probs;
   double a,b,d,etemp;  double *ageexmed,*agecens;
   double fu,fv,fw,fx;  double dateintmean=0;
   double ftemp;  
   double p,q,r,tol1,tol2,u,v,w,x,xm;  double *weight;
   double e=0.0;  int **s; /* Status */
    double *agedc, **covar, idx;
   a=(ax < cx ? ax : cx);  int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;
   b=(ax > cx ? ax : cx);  double *lsurv, *lpop, *tpop;
   x=w=v=bx;  
   fw=fv=fx=(*f)(x);  double ftol=FTOL; /* Tolerance for computing Max Likelihood */
   for (iter=1;iter<=ITMAX;iter++) {  double ftolhess; /* Tolerance for computing hessian */
     xm=0.5*(a+b);  
     tol2=2.0*(tol1=tol*fabs(x)+ZEPS);  /**************** split *************************/
     /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/  static  int split( char *path, char *dirc, char *name, char *ext, char *finame )
     printf(".");fflush(stdout);  {
 #ifdef DEBUG    /* From a file name with (full) path (either Unix or Windows) we extract the directory (dirc)
     printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);       the name of the file (name), its extension only (ext) and its first part of the name (finame)
     /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */    */ 
 #endif    char  *ss;                            /* pointer */
     if (fabs(x-xm) <= (tol2-0.5*(b-a))){    int   l1, l2;                         /* length counters */
       *xmin=x;  
       return fx;    l1 = strlen(path );                   /* length of path */
     }    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );
     ftemp=fu;    ss= strrchr( path, DIRSEPARATOR );            /* find last / */
     if (fabs(e) > tol1) {    if ( ss == NULL ) {                   /* no directory, so determine current directory */
       r=(x-w)*(fx-fv);      strcpy( name, path );               /* we got the fullname name because no directory */
       q=(x-v)*(fx-fw);      /*if(strrchr(path, ODIRSEPARATOR )==NULL)
       p=(x-v)*q-(x-w)*r;        printf("Warning you should use %s as a separator\n",DIRSEPARATOR);*/
       q=2.0*(q-r);      /* get current working directory */
       if (q > 0.0) p = -p;      /*    extern  char* getcwd ( char *buf , int len);*/
       q=fabs(q);      if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {
       etemp=e;        return( GLOCK_ERROR_GETCWD );
       e=d;      }
       if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x))      /* got dirc from getcwd*/
         d=CGOLD*(e=(x >= xm ? a-x : b-x));      printf(" DIRC = %s \n",dirc);
       else {    } else {                              /* strip direcotry from path */
         d=p/q;      ss++;                               /* after this, the filename */
         u=x+d;      l2 = strlen( ss );                  /* length of filename */
         if (u-a < tol2 || b-u < tol2)      if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );
           d=SIGN(tol1,xm-x);      strcpy( name, ss );         /* save file name */
       }      strncpy( dirc, path, l1 - l2 );     /* now the directory */
     } else {      dirc[l1-l2] = 0;                    /* add zero */
       d=CGOLD*(e=(x >= xm ? a-x : b-x));      printf(" DIRC2 = %s \n",dirc);
     }    }
     u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d));    /* We add a separator at the end of dirc if not exists */
     fu=(*f)(u);    l1 = strlen( dirc );                  /* length of directory */
     if (fu <= fx) {    if( dirc[l1-1] != DIRSEPARATOR ){
       if (u >= x) a=x; else b=x;      dirc[l1] =  DIRSEPARATOR;
       SHFT(v,w,x,u)      dirc[l1+1] = 0; 
         SHFT(fv,fw,fx,fu)      printf(" DIRC3 = %s \n",dirc);
         } else {    }
           if (u < x) a=u; else b=u;    ss = strrchr( name, '.' );            /* find last / */
           if (fu <= fw || w == x) {    if (ss >0){
             v=w;      ss++;
             w=u;      strcpy(ext,ss);                     /* save extension */
             fv=fw;      l1= strlen( name);
             fw=fu;      l2= strlen(ss)+1;
           } else if (fu <= fv || v == x || v == w) {      strncpy( finame, name, l1-l2);
             v=u;      finame[l1-l2]= 0;
             fv=fu;    }
           }  
         }    return( 0 );                          /* we're done */
   }  }
   nrerror("Too many iterations in brent");  
   *xmin=x;  
   return fx;  /******************************************/
 }  
   void replace_back_to_slash(char *s, char*t)
 /****************** mnbrak ***********************/  {
     int i;
 void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc,    int lg=0;
             double (*func)(double))    i=0;
 {    lg=strlen(t);
   double ulim,u,r,q, dum;    for(i=0; i<= lg; i++) {
   double fu;      (s[i] = t[i]);
        if (t[i]== '\\') s[i]='/';
   *fa=(*func)(*ax);    }
   *fb=(*func)(*bx);  }
   if (*fb > *fa) {  
     SHFT(dum,*ax,*bx,dum)  int nbocc(char *s, char occ)
       SHFT(dum,*fb,*fa,dum)  {
       }    int i,j=0;
   *cx=(*bx)+GOLD*(*bx-*ax);    int lg=20;
   *fc=(*func)(*cx);    i=0;
   while (*fb > *fc) {    lg=strlen(s);
     r=(*bx-*ax)*(*fb-*fc);    for(i=0; i<= lg; i++) {
     q=(*bx-*cx)*(*fb-*fa);    if  (s[i] == occ ) j++;
     u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/    }
       (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r));    return j;
     ulim=(*bx)+GLIMIT*(*cx-*bx);  }
     if ((*bx-u)*(u-*cx) > 0.0) {  
       fu=(*func)(u);  void cutv(char *u,char *v, char*t, char occ)
     } else if ((*cx-u)*(u-ulim) > 0.0) {  {
       fu=(*func)(u);    /* cuts string t into u and v where u ends before first occurence of char 'occ' 
       if (fu < *fc) {       and v starts after first occurence of char 'occ' : ex cutv(u,v,"abcdef2ghi2j",'2')
         SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx))       gives u="abcedf" and v="ghi2j" */
           SHFT(*fb,*fc,fu,(*func)(u))    int i,lg,j,p=0;
           }    i=0;
     } else if ((u-ulim)*(ulim-*cx) >= 0.0) {    for(j=0; j<=strlen(t)-1; j++) {
       u=ulim;      if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;
       fu=(*func)(u);    }
     } else {  
       u=(*cx)+GOLD*(*cx-*bx);    lg=strlen(t);
       fu=(*func)(u);    for(j=0; j<p; j++) {
     }      (u[j] = t[j]);
     SHFT(*ax,*bx,*cx,u)    }
       SHFT(*fa,*fb,*fc,fu)       u[p]='\0';
       }  
 }     for(j=0; j<= lg; j++) {
       if (j>=(p+1))(v[j-p-1] = t[j]);
 /*************** linmin ************************/    }
   }
 int ncom;  
 double *pcom,*xicom;  /********************** nrerror ********************/
 double (*nrfunc)(double []);  
    void nrerror(char error_text[])
 void linmin(double p[], double xi[], int n, double *fret,double (*func)(double []))  {
 {    fprintf(stderr,"ERREUR ...\n");
   double brent(double ax, double bx, double cx,    fprintf(stderr,"%s\n",error_text);
                double (*f)(double), double tol, double *xmin);    exit(EXIT_FAILURE);
   double f1dim(double x);  }
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb,  /*********************** vector *******************/
               double *fc, double (*func)(double));  double *vector(int nl, int nh)
   int j;  {
   double xx,xmin,bx,ax;    double *v;
   double fx,fb,fa;    v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));
      if (!v) nrerror("allocation failure in vector");
   ncom=n;    return v-nl+NR_END;
   pcom=vector(1,n);  }
   xicom=vector(1,n);  
   nrfunc=func;  /************************ free vector ******************/
   for (j=1;j<=n;j++) {  void free_vector(double*v, int nl, int nh)
     pcom[j]=p[j];  {
     xicom[j]=xi[j];    free((FREE_ARG)(v+nl-NR_END));
   }  }
   ax=0.0;  
   xx=1.0;  /************************ivector *******************************/
   mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim);  int *ivector(long nl,long nh)
   *fret=brent(ax,xx,bx,f1dim,TOL,&xmin);  {
 #ifdef DEBUG    int *v;
   printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);    v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));
 #endif    if (!v) nrerror("allocation failure in ivector");
   for (j=1;j<=n;j++) {    return v-nl+NR_END;
     xi[j] *= xmin;  }
     p[j] += xi[j];  
   }  /******************free ivector **************************/
   free_vector(xicom,1,n);  void free_ivector(int *v, long nl, long nh)
   free_vector(pcom,1,n);  {
 }    free((FREE_ARG)(v+nl-NR_END));
   }
 /*************** powell ************************/  
 void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret,  /************************lvector *******************************/
             double (*func)(double []))  long *lvector(long nl,long nh)
 {  {
   void linmin(double p[], double xi[], int n, double *fret,    long *v;
               double (*func)(double []));    v=(long *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(long)));
   int i,ibig,j;    if (!v) nrerror("allocation failure in ivector");
   double del,t,*pt,*ptt,*xit;    return v-nl+NR_END;
   double fp,fptt;  }
   double *xits;  
   pt=vector(1,n);  /******************free lvector **************************/
   ptt=vector(1,n);  void free_lvector(long *v, long nl, long nh)
   xit=vector(1,n);  {
   xits=vector(1,n);    free((FREE_ARG)(v+nl-NR_END));
   *fret=(*func)(p);  }
   for (j=1;j<=n;j++) pt[j]=p[j];  
   for (*iter=1;;++(*iter)) {  /******************* imatrix *******************************/
     fp=(*fret);  int **imatrix(long nrl, long nrh, long ncl, long nch) 
     ibig=0;       /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */ 
     del=0.0;  { 
     printf("\nPowell iter=%d -2*LL=%.12f",*iter,*fret);    long i, nrow=nrh-nrl+1,ncol=nch-ncl+1; 
     for (i=1;i<=n;i++)    int **m; 
       printf(" %d %.12f",i, p[i]);    
     printf("\n");    /* allocate pointers to rows */ 
     for (i=1;i<=n;i++) {    m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*))); 
       for (j=1;j<=n;j++) xit[j]=xi[j][i];    if (!m) nrerror("allocation failure 1 in matrix()"); 
       fptt=(*fret);    m += NR_END; 
 #ifdef DEBUG    m -= nrl; 
       printf("fret=%lf \n",*fret);    
 #endif    
       printf("%d",i);fflush(stdout);    /* allocate rows and set pointers to them */ 
       linmin(p,xit,n,fret,func);    m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int))); 
       if (fabs(fptt-(*fret)) > del) {    if (!m[nrl]) nrerror("allocation failure 2 in matrix()"); 
         del=fabs(fptt-(*fret));    m[nrl] += NR_END; 
         ibig=i;    m[nrl] -= ncl; 
       }    
 #ifdef DEBUG    for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol; 
       printf("%d %.12e",i,(*fret));    
       for (j=1;j<=n;j++) {    /* return pointer to array of pointers to rows */ 
         xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);    return m; 
         printf(" x(%d)=%.12e",j,xit[j]);  } 
       }  
       for(j=1;j<=n;j++)  /****************** free_imatrix *************************/
         printf(" p=%.12e",p[j]);  void free_imatrix(m,nrl,nrh,ncl,nch)
       printf("\n");        int **m;
 #endif        long nch,ncl,nrh,nrl; 
     }       /* free an int matrix allocated by imatrix() */ 
     if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {  { 
 #ifdef DEBUG    free((FREE_ARG) (m[nrl]+ncl-NR_END)); 
       int k[2],l;    free((FREE_ARG) (m+nrl-NR_END)); 
       k[0]=1;  } 
       k[1]=-1;  
       printf("Max: %.12e",(*func)(p));  /******************* matrix *******************************/
       for (j=1;j<=n;j++)  double **matrix(long nrl, long nrh, long ncl, long nch)
         printf(" %.12e",p[j]);  {
       printf("\n");    long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;
       for(l=0;l<=1;l++) {    double **m;
         for (j=1;j<=n;j++) {  
           ptt[j]=p[j]+(p[j]-pt[j])*k[l];    m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
           printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);    if (!m) nrerror("allocation failure 1 in matrix()");
         }    m += NR_END;
         printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));    m -= nrl;
       }  
 #endif    m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
     if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
     m[nrl] += NR_END;
       free_vector(xit,1,n);    m[nrl] -= ncl;
       free_vector(xits,1,n);  
       free_vector(ptt,1,n);    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
       free_vector(pt,1,n);    return m;
       return;    /* print *(*(m+1)+70) or print m[1][70]; print m+1 or print &(m[1]) 
     }     */
     if (*iter == ITMAX) nrerror("powell exceeding maximum iterations.");  }
     for (j=1;j<=n;j++) {  
       ptt[j]=2.0*p[j]-pt[j];  /*************************free matrix ************************/
       xit[j]=p[j]-pt[j];  void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)
       pt[j]=p[j];  {
     }    free((FREE_ARG)(m[nrl]+ncl-NR_END));
     fptt=(*func)(ptt);    free((FREE_ARG)(m+nrl-NR_END));
     if (fptt < fp) {  }
       t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt);  
       if (t < 0.0) {  /******************* ma3x *******************************/
         linmin(p,xit,n,fret,func);  double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)
         for (j=1;j<=n;j++) {  {
           xi[j][ibig]=xi[j][n];    long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;
           xi[j][n]=xit[j];    double ***m;
         }  
 #ifdef DEBUG    m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
         printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);    if (!m) nrerror("allocation failure 1 in matrix()");
         for(j=1;j<=n;j++)    m += NR_END;
           printf(" %.12e",xit[j]);    m -= nrl;
         printf("\n");  
 #endif    m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
       }    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
     }    m[nrl] += NR_END;
   }    m[nrl] -= ncl;
 }  
     for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
 /**** Prevalence limit ****************/  
     m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));
 double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)    if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");
 {    m[nrl][ncl] += NR_END;
   /* Computes the prevalence limit in each live state at age x by left multiplying the unit    m[nrl][ncl] -= nll;
      matrix by transitions matrix until convergence is reached */    for (j=ncl+1; j<=nch; j++) 
       m[nrl][j]=m[nrl][j-1]+nlay;
   int i, ii,j,k;    
   double min, max, maxmin, maxmax,sumnew=0.;    for (i=nrl+1; i<=nrh; i++) {
   double **matprod2();      m[i][ncl]=m[i-1l][ncl]+ncol*nlay;
   double **out, cov[NCOVMAX], **pmij();      for (j=ncl+1; j<=nch; j++) 
   double **newm;        m[i][j]=m[i][j-1]+nlay;
   double agefin, delaymax=50 ; /* Max number of years to converge */    }
     return m; 
   for (ii=1;ii<=nlstate+ndeath;ii++)    /*  gdb: p *(m+1) <=> p m[1] and p (m+1) <=> p (m+1) <=> p &(m[1])
     for (j=1;j<=nlstate+ndeath;j++){             &(m[i][j][k]) <=> *((*(m+i) + j)+k)
       oldm[ii][j]=(ii==j ? 1.0 : 0.0);    */
     }  }
   
    cov[1]=1.;  /*************************free ma3x ************************/
    void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)
  /* Even if hstepm = 1, at least one multiplication by the unit matrix */  {
   for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){    free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));
     newm=savm;    free((FREE_ARG)(m[nrl]+ncl-NR_END));
     /* Covariates have to be included here again */    free((FREE_ARG)(m+nrl-NR_END));
      cov[2]=agefin;  }
    
       for (k=1; k<=cptcovn;k++) {  /*************** function subdirf ***********/
         cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];  char *subdirf(char fileres[])
         /*printf("ij=%d Tvar[k]=%d nbcode=%d cov=%lf\n",ij, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k]);*/  {
       }    /* Caution optionfilefiname is hidden */
       for (k=1; k<=cptcovage;k++)    strcpy(tmpout,optionfilefiname);
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];    strcat(tmpout,"/"); /* Add to the right */
       for (k=1; k<=cptcovprod;k++)    strcat(tmpout,fileres);
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];    return tmpout;
   }
       /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/  
       /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/  /*************** function subdirf2 ***********/
   char *subdirf2(char fileres[], char *preop)
     out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);  {
     
     savm=oldm;    /* Caution optionfilefiname is hidden */
     oldm=newm;    strcpy(tmpout,optionfilefiname);
     maxmax=0.;    strcat(tmpout,"/");
     for(j=1;j<=nlstate;j++){    strcat(tmpout,preop);
       min=1.;    strcat(tmpout,fileres);
       max=0.;    return tmpout;
       for(i=1; i<=nlstate; i++) {  }
         sumnew=0;  
         for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];  /*************** function subdirf3 ***********/
         prlim[i][j]= newm[i][j]/(1-sumnew);  char *subdirf3(char fileres[], char *preop, char *preop2)
         max=FMAX(max,prlim[i][j]);  {
         min=FMIN(min,prlim[i][j]);    
       }    /* Caution optionfilefiname is hidden */
       maxmin=max-min;    strcpy(tmpout,optionfilefiname);
       maxmax=FMAX(maxmax,maxmin);    strcat(tmpout,"/");
     }    strcat(tmpout,preop);
     if(maxmax < ftolpl){    strcat(tmpout,preop2);
       return prlim;    strcat(tmpout,fileres);
     }    return tmpout;
   }  }
 }  
   /***************** f1dim *************************/
 /*************** transition probabilities ***************/  extern int ncom; 
   extern double *pcom,*xicom;
 double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )  extern double (*nrfunc)(double []); 
 {   
   double s1, s2;  double f1dim(double x) 
   /*double t34;*/  { 
   int i,j,j1, nc, ii, jj;    int j; 
     double f;
     for(i=1; i<= nlstate; i++){    double *xt; 
     for(j=1; j<i;j++){   
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){    xt=vector(1,ncom); 
         /*s2 += param[i][j][nc]*cov[nc];*/    for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j]; 
         s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    f=(*nrfunc)(xt); 
         /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/    free_vector(xt,1,ncom); 
       }    return f; 
       ps[i][j]=s2;  } 
       /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/  
     }  /*****************brent *************************/
     for(j=i+1; j<=nlstate+ndeath;j++){  double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin) 
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){  { 
         s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    int iter; 
         /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/    double a,b,d,etemp;
       }    double fu,fv,fw,fx;
       ps[i][j]=(s2);    double ftemp;
     }    double p,q,r,tol1,tol2,u,v,w,x,xm; 
   }    double e=0.0; 
     /*ps[3][2]=1;*/   
     a=(ax < cx ? ax : cx); 
   for(i=1; i<= nlstate; i++){    b=(ax > cx ? ax : cx); 
      s1=0;    x=w=v=bx; 
     for(j=1; j<i; j++)    fw=fv=fx=(*f)(x); 
       s1+=exp(ps[i][j]);    for (iter=1;iter<=ITMAX;iter++) { 
     for(j=i+1; j<=nlstate+ndeath; j++)      xm=0.5*(a+b); 
       s1+=exp(ps[i][j]);      tol2=2.0*(tol1=tol*fabs(x)+ZEPS); 
     ps[i][i]=1./(s1+1.);      /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/
     for(j=1; j<i; j++)      printf(".");fflush(stdout);
       ps[i][j]= exp(ps[i][j])*ps[i][i];      fprintf(ficlog,".");fflush(ficlog);
     for(j=i+1; j<=nlstate+ndeath; j++)  #ifdef DEBUG
       ps[i][j]= exp(ps[i][j])*ps[i][i];      printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
     /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */      fprintf(ficlog,"br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
   } /* end i */      /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */
   #endif
   for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){      if (fabs(x-xm) <= (tol2-0.5*(b-a))){ 
     for(jj=1; jj<= nlstate+ndeath; jj++){        *xmin=x; 
       ps[ii][jj]=0;        return fx; 
       ps[ii][ii]=1;      } 
     }      ftemp=fu;
   }      if (fabs(e) > tol1) { 
         r=(x-w)*(fx-fv); 
         q=(x-v)*(fx-fw); 
   /*   for(ii=1; ii<= nlstate+ndeath; ii++){        p=(x-v)*q-(x-w)*r; 
     for(jj=1; jj<= nlstate+ndeath; jj++){        q=2.0*(q-r); 
      printf("%lf ",ps[ii][jj]);        if (q > 0.0) p = -p; 
    }        q=fabs(q); 
     printf("\n ");        etemp=e; 
     }        e=d; 
     printf("\n ");printf("%lf ",cov[2]);*/        if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x)) 
 /*          d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
   for(i=1; i<= npar; i++) printf("%f ",x[i]);        else { 
   goto end;*/          d=p/q; 
     return ps;          u=x+d; 
 }          if (u-a < tol2 || b-u < tol2) 
             d=SIGN(tol1,xm-x); 
 /**************** Product of 2 matrices ******************/        } 
       } else { 
 double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)        d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
 {      } 
   /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times      u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d)); 
      b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */      fu=(*f)(u); 
   /* in, b, out are matrice of pointers which should have been initialized      if (fu <= fx) { 
      before: only the contents of out is modified. The function returns        if (u >= x) a=x; else b=x; 
      a pointer to pointers identical to out */        SHFT(v,w,x,u) 
   long i, j, k;          SHFT(fv,fw,fx,fu) 
   for(i=nrl; i<= nrh; i++)          } else { 
     for(k=ncolol; k<=ncoloh; k++)            if (u < x) a=u; else b=u; 
       for(j=ncl,out[i][k]=0.; j<=nch; j++)            if (fu <= fw || w == x) { 
         out[i][k] +=in[i][j]*b[j][k];              v=w; 
               w=u; 
   return out;              fv=fw; 
 }              fw=fu; 
             } else if (fu <= fv || v == x || v == w) { 
               v=u; 
 /************* Higher Matrix Product ***************/              fv=fu; 
             } 
 double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )          } 
 {    } 
   /* Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' month    nrerror("Too many iterations in brent"); 
      duration (i.e. until    *xmin=x; 
      age (in years)  age+nhstepm*stepm/12) by multiplying nhstepm*hstepm matrices.    return fx; 
      Output is stored in matrix po[i][j][h] for h every 'hstepm' step  } 
      (typically every 2 years instead of every month which is too big).  
      Model is determined by parameters x and covariates have to be  /****************** mnbrak ***********************/
      included manually here.  
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc, 
      */              double (*func)(double)) 
   { 
   int i, j, d, h, k;    double ulim,u,r,q, dum;
   double **out, cov[NCOVMAX];    double fu; 
   double **newm;   
     *fa=(*func)(*ax); 
   /* Hstepm could be zero and should return the unit matrix */    *fb=(*func)(*bx); 
   for (i=1;i<=nlstate+ndeath;i++)    if (*fb > *fa) { 
     for (j=1;j<=nlstate+ndeath;j++){      SHFT(dum,*ax,*bx,dum) 
       oldm[i][j]=(i==j ? 1.0 : 0.0);        SHFT(dum,*fb,*fa,dum) 
       po[i][j][0]=(i==j ? 1.0 : 0.0);        } 
     }    *cx=(*bx)+GOLD*(*bx-*ax); 
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */    *fc=(*func)(*cx); 
   for(h=1; h <=nhstepm; h++){    while (*fb > *fc) { 
     for(d=1; d <=hstepm; d++){      r=(*bx-*ax)*(*fb-*fc); 
       newm=savm;      q=(*bx-*cx)*(*fb-*fa); 
       /* Covariates have to be included here again */      u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/ 
       cov[1]=1.;        (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r)); 
       cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;      ulim=(*bx)+GLIMIT*(*cx-*bx); 
       for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];      if ((*bx-u)*(u-*cx) > 0.0) { 
       for (k=1; k<=cptcovage;k++)        fu=(*func)(u); 
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];      } else if ((*cx-u)*(u-ulim) > 0.0) { 
       for (k=1; k<=cptcovprod;k++)        fu=(*func)(u); 
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];        if (fu < *fc) { 
           SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx)) 
             SHFT(*fb,*fc,fu,(*func)(u)) 
       /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/            } 
       /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/      } else if ((u-ulim)*(ulim-*cx) >= 0.0) { 
       out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath,        u=ulim; 
                    pmij(pmmij,cov,ncovmodel,x,nlstate));        fu=(*func)(u); 
       savm=oldm;      } else { 
       oldm=newm;        u=(*cx)+GOLD*(*cx-*bx); 
     }        fu=(*func)(u); 
     for(i=1; i<=nlstate+ndeath; i++)      } 
       for(j=1;j<=nlstate+ndeath;j++) {      SHFT(*ax,*bx,*cx,u) 
         po[i][j][h]=newm[i][j];        SHFT(*fa,*fb,*fc,fu) 
         /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);        } 
          */  } 
       }  
   } /* end h */  /*************** linmin ************************/
   return po;  
 }  int ncom; 
   double *pcom,*xicom;
   double (*nrfunc)(double []); 
 /*************** log-likelihood *************/   
 double func( double *x)  void linmin(double p[], double xi[], int n, double *fret,double (*func)(double [])) 
 {  { 
   int i, ii, j, k, mi, d, kk;    double brent(double ax, double bx, double cx, 
   double l, ll[NLSTATEMAX], cov[NCOVMAX];                 double (*f)(double), double tol, double *xmin); 
   double **out;    double f1dim(double x); 
   double sw; /* Sum of weights */    void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, 
   double lli; /* Individual log likelihood */                double *fc, double (*func)(double)); 
   long ipmx;    int j; 
   /*extern weight */    double xx,xmin,bx,ax; 
   /* We are differentiating ll according to initial status */    double fx,fb,fa;
   /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/   
   /*for(i=1;i<imx;i++)    ncom=n; 
     printf(" %d\n",s[4][i]);    pcom=vector(1,n); 
   */    xicom=vector(1,n); 
   cov[1]=1.;    nrfunc=func; 
     for (j=1;j<=n;j++) { 
   for(k=1; k<=nlstate; k++) ll[k]=0.;      pcom[j]=p[j]; 
   for (i=1,ipmx=0, sw=0.; i<=imx; i++){      xicom[j]=xi[j]; 
     for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];    } 
     for(mi=1; mi<= wav[i]-1; mi++){    ax=0.0; 
       for (ii=1;ii<=nlstate+ndeath;ii++)    xx=1.0; 
         for (j=1;j<=nlstate+ndeath;j++) oldm[ii][j]=(ii==j ? 1.0 : 0.0);    mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim); 
       for(d=0; d<dh[mi][i]; d++){    *fret=brent(ax,xx,bx,f1dim,TOL,&xmin); 
         newm=savm;  #ifdef DEBUG
         cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;    printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
         for (kk=1; kk<=cptcovage;kk++) {    fprintf(ficlog,"retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
           cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];  #endif
         }    for (j=1;j<=n;j++) { 
              xi[j] *= xmin; 
         out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,      p[j] += xi[j]; 
                      1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));    } 
         savm=oldm;    free_vector(xicom,1,n); 
         oldm=newm;    free_vector(pcom,1,n); 
          } 
          
       } /* end mult */  char *asc_diff_time(long time_sec, char ascdiff[])
        {
       lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);    long sec_left, days, hours, minutes;
       /* printf(" %f ",out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/    days = (time_sec) / (60*60*24);
       ipmx +=1;    sec_left = (time_sec) % (60*60*24);
       sw += weight[i];    hours = (sec_left) / (60*60) ;
       ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;    sec_left = (sec_left) %(60*60);
     } /* end of wave */    minutes = (sec_left) /60;
   } /* end of individual */    sec_left = (sec_left) % (60);
     sprintf(ascdiff,"%d day(s) %d hour(s) %d minute(s) %d second(s)",days, hours, minutes, sec_left);  
   for(k=1,l=0.; k<=nlstate; k++) l += ll[k];    return ascdiff;
   /* printf("l1=%f l2=%f ",ll[1],ll[2]); */  }
   l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */  
   return -l;  /*************** powell ************************/
 }  void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret, 
               double (*func)(double [])) 
   { 
 /*********** Maximum Likelihood Estimation ***************/    void linmin(double p[], double xi[], int n, double *fret, 
                 double (*func)(double [])); 
 void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))    int i,ibig,j; 
 {    double del,t,*pt,*ptt,*xit;
   int i,j, iter;    double fp,fptt;
   double **xi,*delti;    double *xits;
   double fret;    int niterf, itmp;
   xi=matrix(1,npar,1,npar);  
   for (i=1;i<=npar;i++)    pt=vector(1,n); 
     for (j=1;j<=npar;j++)    ptt=vector(1,n); 
       xi[i][j]=(i==j ? 1.0 : 0.0);    xit=vector(1,n); 
   printf("Powell\n");    xits=vector(1,n); 
   powell(p,xi,npar,ftol,&iter,&fret,func);    *fret=(*func)(p); 
     for (j=1;j<=n;j++) pt[j]=p[j]; 
    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));    for (*iter=1;;++(*iter)) { 
   fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f ",iter,func(p));      fp=(*fret); 
       ibig=0; 
 }      del=0.0; 
       last_time=curr_time;
 /**** Computes Hessian and covariance matrix ***/      (void) gettimeofday(&curr_time,&tzp);
 void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))      printf("\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);fflush(stdout);
 {      /*    fprintf(ficlog,"\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);
   double  **a,**y,*x,pd;      fprintf(ficrespow,"%d %.12f %ld",*iter,*fret,curr_time.tv_sec-start_time.tv_sec);
   double **hess;      */
   int i, j,jk;     for (i=1;i<=n;i++) {
   int *indx;        printf(" %d %.12f",i, p[i]);
         fprintf(ficlog," %d %.12lf",i, p[i]);
   double hessii(double p[], double delta, int theta, double delti[]);        fprintf(ficrespow," %.12lf", p[i]);
   double hessij(double p[], double delti[], int i, int j);      }
   void lubksb(double **a, int npar, int *indx, double b[]) ;      printf("\n");
   void ludcmp(double **a, int npar, int *indx, double *d) ;      fprintf(ficlog,"\n");
       fprintf(ficrespow,"\n");fflush(ficrespow);
   hess=matrix(1,npar,1,npar);      if(*iter <=3){
         tm = *localtime(&curr_time.tv_sec);
   printf("\nCalculation of the hessian matrix. Wait...\n");        strcpy(strcurr,asctime(&tm));
   for (i=1;i<=npar;i++){  /*       asctime_r(&tm,strcurr); */
     printf("%d",i);fflush(stdout);        forecast_time=curr_time; 
     hess[i][i]=hessii(p,ftolhess,i,delti);        itmp = strlen(strcurr);
     /*printf(" %f ",p[i]);*/        if(strcurr[itmp-1]=='\n')  /* Windows outputs with a new line */
     /*printf(" %lf ",hess[i][i]);*/          strcurr[itmp-1]='\0';
   }        printf("\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
          fprintf(ficlog,"\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
   for (i=1;i<=npar;i++) {        for(niterf=10;niterf<=30;niterf+=10){
     for (j=1;j<=npar;j++)  {          forecast_time.tv_sec=curr_time.tv_sec+(niterf-*iter)*(curr_time.tv_sec-last_time.tv_sec);
       if (j>i) {          tmf = *localtime(&forecast_time.tv_sec);
         printf(".%d%d",i,j);fflush(stdout);  /*      asctime_r(&tmf,strfor); */
         hess[i][j]=hessij(p,delti,i,j);          strcpy(strfor,asctime(&tmf));
         hess[j][i]=hess[i][j];              itmp = strlen(strfor);
         /*printf(" %lf ",hess[i][j]);*/          if(strfor[itmp-1]=='\n')
       }          strfor[itmp-1]='\0';
     }          printf("   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   }          fprintf(ficlog,"   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   printf("\n");        }
       }
   printf("\nInverting the hessian to get the covariance matrix. Wait...\n");      for (i=1;i<=n;i++) { 
          for (j=1;j<=n;j++) xit[j]=xi[j][i]; 
   a=matrix(1,npar,1,npar);        fptt=(*fret); 
   y=matrix(1,npar,1,npar);  #ifdef DEBUG
   x=vector(1,npar);        printf("fret=%lf \n",*fret);
   indx=ivector(1,npar);        fprintf(ficlog,"fret=%lf \n",*fret);
   for (i=1;i<=npar;i++)  #endif
     for (j=1;j<=npar;j++) a[i][j]=hess[i][j];        printf("%d",i);fflush(stdout);
   ludcmp(a,npar,indx,&pd);        fprintf(ficlog,"%d",i);fflush(ficlog);
         linmin(p,xit,n,fret,func); 
   for (j=1;j<=npar;j++) {        if (fabs(fptt-(*fret)) > del) { 
     for (i=1;i<=npar;i++) x[i]=0;          del=fabs(fptt-(*fret)); 
     x[j]=1;          ibig=i; 
     lubksb(a,npar,indx,x);        } 
     for (i=1;i<=npar;i++){  #ifdef DEBUG
       matcov[i][j]=x[i];        printf("%d %.12e",i,(*fret));
     }        fprintf(ficlog,"%d %.12e",i,(*fret));
   }        for (j=1;j<=n;j++) {
           xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);
   printf("\n#Hessian matrix#\n");          printf(" x(%d)=%.12e",j,xit[j]);
   for (i=1;i<=npar;i++) {          fprintf(ficlog," x(%d)=%.12e",j,xit[j]);
     for (j=1;j<=npar;j++) {        }
       printf("%.3e ",hess[i][j]);        for(j=1;j<=n;j++) {
     }          printf(" p=%.12e",p[j]);
     printf("\n");          fprintf(ficlog," p=%.12e",p[j]);
   }        }
         printf("\n");
   /* Recompute Inverse */        fprintf(ficlog,"\n");
   for (i=1;i<=npar;i++)  #endif
     for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];      } 
   ludcmp(a,npar,indx,&pd);      if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {
   #ifdef DEBUG
   /*  printf("\n#Hessian matrix recomputed#\n");        int k[2],l;
         k[0]=1;
   for (j=1;j<=npar;j++) {        k[1]=-1;
     for (i=1;i<=npar;i++) x[i]=0;        printf("Max: %.12e",(*func)(p));
     x[j]=1;        fprintf(ficlog,"Max: %.12e",(*func)(p));
     lubksb(a,npar,indx,x);        for (j=1;j<=n;j++) {
     for (i=1;i<=npar;i++){          printf(" %.12e",p[j]);
       y[i][j]=x[i];          fprintf(ficlog," %.12e",p[j]);
       printf("%.3e ",y[i][j]);        }
     }        printf("\n");
     printf("\n");        fprintf(ficlog,"\n");
   }        for(l=0;l<=1;l++) {
   */          for (j=1;j<=n;j++) {
             ptt[j]=p[j]+(p[j]-pt[j])*k[l];
   free_matrix(a,1,npar,1,npar);            printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
   free_matrix(y,1,npar,1,npar);            fprintf(ficlog,"l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
   free_vector(x,1,npar);          }
   free_ivector(indx,1,npar);          printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
   free_matrix(hess,1,npar,1,npar);          fprintf(ficlog,"func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
         }
   #endif
 }  
   
 /*************** hessian matrix ****************/        free_vector(xit,1,n); 
 double hessii( double x[], double delta, int theta, double delti[])        free_vector(xits,1,n); 
 {        free_vector(ptt,1,n); 
   int i;        free_vector(pt,1,n); 
   int l=1, lmax=20;        return; 
   double k1,k2;      } 
   double p2[NPARMAX+1];      if (*iter == ITMAX) nrerror("powell exceeding maximum iterations."); 
   double res;      for (j=1;j<=n;j++) { 
   double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;        ptt[j]=2.0*p[j]-pt[j]; 
   double fx;        xit[j]=p[j]-pt[j]; 
   int k=0,kmax=10;        pt[j]=p[j]; 
   double l1;      } 
       fptt=(*func)(ptt); 
   fx=func(x);      if (fptt < fp) { 
   for (i=1;i<=npar;i++) p2[i]=x[i];        t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt); 
   for(l=0 ; l <=lmax; l++){        if (t < 0.0) { 
     l1=pow(10,l);          linmin(p,xit,n,fret,func); 
     delts=delt;          for (j=1;j<=n;j++) { 
     for(k=1 ; k <kmax; k=k+1){            xi[j][ibig]=xi[j][n]; 
       delt = delta*(l1*k);            xi[j][n]=xit[j]; 
       p2[theta]=x[theta] +delt;          }
       k1=func(p2)-fx;  #ifdef DEBUG
       p2[theta]=x[theta]-delt;          printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
       k2=func(p2)-fx;          fprintf(ficlog,"Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
       /*res= (k1-2.0*fx+k2)/delt/delt; */          for(j=1;j<=n;j++){
       res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */            printf(" %.12e",xit[j]);
                  fprintf(ficlog," %.12e",xit[j]);
 #ifdef DEBUG          }
       printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);          printf("\n");
 #endif          fprintf(ficlog,"\n");
       /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */  #endif
       if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){        }
         k=kmax;      } 
       }    } 
       else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */  } 
         k=kmax; l=lmax*10.;  
       }  /**** Prevalence limit (stable prevalence)  ****************/
       else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){  
         delts=delt;  double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)
       }  {
     }    /* Computes the prevalence limit in each live state at age x by left multiplying the unit
   }       matrix by transitions matrix until convergence is reached */
   delti[theta]=delts;  
   return res;    int i, ii,j,k;
      double min, max, maxmin, maxmax,sumnew=0.;
 }    double **matprod2();
     double **out, cov[NCOVMAX], **pmij();
 double hessij( double x[], double delti[], int thetai,int thetaj)    double **newm;
 {    double agefin, delaymax=50 ; /* Max number of years to converge */
   int i;  
   int l=1, l1, lmax=20;    for (ii=1;ii<=nlstate+ndeath;ii++)
   double k1,k2,k3,k4,res,fx;      for (j=1;j<=nlstate+ndeath;j++){
   double p2[NPARMAX+1];        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   int k;      }
   
   fx=func(x);     cov[1]=1.;
   for (k=1; k<=2; k++) {   
     for (i=1;i<=npar;i++) p2[i]=x[i];   /* Even if hstepm = 1, at least one multiplication by the unit matrix */
     p2[thetai]=x[thetai]+delti[thetai]/k;    for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;      newm=savm;
     k1=func(p2)-fx;      /* Covariates have to be included here again */
         cov[2]=agefin;
     p2[thetai]=x[thetai]+delti[thetai]/k;    
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;        for (k=1; k<=cptcovn;k++) {
     k2=func(p2)-fx;          cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
            /*      printf("ij=%d k=%d Tvar[k]=%d nbcode=%d cov=%lf codtab[ij][Tvar[k]]=%d \n",ij,k, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k], codtab[ij][Tvar[k]]);*/
     p2[thetai]=x[thetai]-delti[thetai]/k;        }
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;        for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
     k3=func(p2)-fx;        for (k=1; k<=cptcovprod;k++)
            cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
     p2[thetai]=x[thetai]-delti[thetai]/k;  
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;        /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/
     k4=func(p2)-fx;        /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/
     res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */        /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/
 #ifdef DEBUG      out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);
     printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);  
 #endif      savm=oldm;
   }      oldm=newm;
   return res;      maxmax=0.;
 }      for(j=1;j<=nlstate;j++){
         min=1.;
 /************** Inverse of matrix **************/        max=0.;
 void ludcmp(double **a, int n, int *indx, double *d)        for(i=1; i<=nlstate; i++) {
 {          sumnew=0;
   int i,imax,j,k;          for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];
   double big,dum,sum,temp;          prlim[i][j]= newm[i][j]/(1-sumnew);
   double *vv;          max=FMAX(max,prlim[i][j]);
            min=FMIN(min,prlim[i][j]);
   vv=vector(1,n);        }
   *d=1.0;        maxmin=max-min;
   for (i=1;i<=n;i++) {        maxmax=FMAX(maxmax,maxmin);
     big=0.0;      }
     for (j=1;j<=n;j++)      if(maxmax < ftolpl){
       if ((temp=fabs(a[i][j])) > big) big=temp;        return prlim;
     if (big == 0.0) nrerror("Singular matrix in routine ludcmp");      }
     vv[i]=1.0/big;    }
   }  }
   for (j=1;j<=n;j++) {  
     for (i=1;i<j;i++) {  /*************** transition probabilities ***************/ 
       sum=a[i][j];  
       for (k=1;k<i;k++) sum -= a[i][k]*a[k][j];  double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )
       a[i][j]=sum;  {
     }    double s1, s2;
     big=0.0;    /*double t34;*/
     for (i=j;i<=n;i++) {    int i,j,j1, nc, ii, jj;
       sum=a[i][j];  
       for (k=1;k<j;k++)      for(i=1; i<= nlstate; i++){
         sum -= a[i][k]*a[k][j];        for(j=1; j<i;j++){
       a[i][j]=sum;          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
       if ( (dum=vv[i]*fabs(sum)) >= big) {            /*s2 += param[i][j][nc]*cov[nc];*/
         big=dum;            s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
         imax=i;  /*       printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2); */
       }          }
     }          ps[i][j]=s2;
     if (j != imax) {  /*      printf("s1=%.17e, s2=%.17e\n",s1,s2); */
       for (k=1;k<=n;k++) {        }
         dum=a[imax][k];        for(j=i+1; j<=nlstate+ndeath;j++){
         a[imax][k]=a[j][k];          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
         a[j][k]=dum;            s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
       }  /*        printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2); */
       *d = -(*d);          }
       vv[imax]=vv[j];          ps[i][j]=s2;
     }        }
     indx[j]=imax;      }
     if (a[j][j] == 0.0) a[j][j]=TINY;      /*ps[3][2]=1;*/
     if (j != n) {      
       dum=1.0/(a[j][j]);      for(i=1; i<= nlstate; i++){
       for (i=j+1;i<=n;i++) a[i][j] *= dum;        s1=0;
     }        for(j=1; j<i; j++)
   }          s1+=exp(ps[i][j]);
   free_vector(vv,1,n);  /* Doesn't work */        for(j=i+1; j<=nlstate+ndeath; j++)
 ;          s1+=exp(ps[i][j]);
 }        ps[i][i]=1./(s1+1.);
         for(j=1; j<i; j++)
 void lubksb(double **a, int n, int *indx, double b[])          ps[i][j]= exp(ps[i][j])*ps[i][i];
 {        for(j=i+1; j<=nlstate+ndeath; j++)
   int i,ii=0,ip,j;          ps[i][j]= exp(ps[i][j])*ps[i][i];
   double sum;        /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */
        } /* end i */
   for (i=1;i<=n;i++) {      
     ip=indx[i];      for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){
     sum=b[ip];        for(jj=1; jj<= nlstate+ndeath; jj++){
     b[ip]=b[i];          ps[ii][jj]=0;
     if (ii)          ps[ii][ii]=1;
       for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j];        }
     else if (sum) ii=i;      }
     b[i]=sum;      
   }  
   for (i=n;i>=1;i--) {  /*        for(ii=1; ii<= nlstate+ndeath; ii++){ */
     sum=b[i];  /*       for(jj=1; jj<= nlstate+ndeath; jj++){ */
     for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j];  /*         printf("ddd %lf ",ps[ii][jj]); */
     b[i]=sum/a[i][i];  /*       } */
   }  /*       printf("\n "); */
 }  /*        } */
   /*        printf("\n ");printf("%lf ",cov[2]); */
 /************ Frequencies ********************/         /*
 void  freqsummary(char fileres[], int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax, int fprev1,int lprev1,double **mint,double **anint, int boolprev, double dateprev1,double dateprev2)        for(i=1; i<= npar; i++) printf("%f ",x[i]);
 {  /* Some frequencies */        goto end;*/
        return ps;
   int i, m, jk, k1,i1, j1, bool, z1,z2,j;  }
   double ***freq; /* Frequencies */  
   double *pp;  /**************** Product of 2 matrices ******************/
   double pos, k2;  
   FILE *ficresp;  double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)
   char fileresp[FILENAMELENGTH];  {
     /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times
   pp=vector(1,nlstate);       b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */
   probs= ma3x(1,130 ,1,8, 1,8);    /* in, b, out are matrice of pointers which should have been initialized 
   strcpy(fileresp,"p");       before: only the contents of out is modified. The function returns
   strcat(fileresp,fileres);       a pointer to pointers identical to out */
   if((ficresp=fopen(fileresp,"w"))==NULL) {    long i, j, k;
     printf("Problem with prevalence resultfile: %s\n", fileresp);    for(i=nrl; i<= nrh; i++)
     exit(0);      for(k=ncolol; k<=ncoloh; k++)
   }        for(j=ncl,out[i][k]=0.; j<=nch; j++)
   freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);          out[i][k] +=in[i][j]*b[j][k];
   j1=0;  
     return out;
   j=cptcoveff;  }
   if (cptcovn<1) {j=1;ncodemax[1]=1;}  
   
   for(k1=1; k1<=j;k1++){  /************* Higher Matrix Product ***************/
    for(i1=1; i1<=ncodemax[k1];i1++){  
        j1++;  double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )
        /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);  {
          scanf("%d", i);*/    /* Computes the transition matrix starting at age 'age' over 
         for (i=-1; i<=nlstate+ndeath; i++)         'nhstepm*hstepm*stepm' months (i.e. until
          for (jk=-1; jk<=nlstate+ndeath; jk++)         age (in years)  age+nhstepm*hstepm*stepm/12) by multiplying 
            for(m=agemin; m <= agemax+3; m++)       nhstepm*hstepm matrices. 
              freq[i][jk][m]=0;       Output is stored in matrix po[i][j][h] for h every 'hstepm' step 
               (typically every 2 years instead of every month which is too big 
        for (i=1; i<=imx; i++) {       for the memory).
          bool=1;       Model is determined by parameters x and covariates have to be 
          if  (cptcovn>0) {       included manually here. 
            for (z1=1; z1<=cptcoveff; z1++)  
              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]])       */
                bool=0;  
          }    int i, j, d, h, k;
          if (bool==1) {    double **out, cov[NCOVMAX];
            if (boolprev==1){    double **newm;
              for(m=fprev1; m<=lprev1; m++){  
                if(agev[m][i]==0) agev[m][i]=agemax+1;    /* Hstepm could be zero and should return the unit matrix */
                if(agev[m][i]==1) agev[m][i]=agemax+2;    for (i=1;i<=nlstate+ndeath;i++)
                freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];      for (j=1;j<=nlstate+ndeath;j++){
                freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];        oldm[i][j]=(i==j ? 1.0 : 0.0);
              }        po[i][j][0]=(i==j ? 1.0 : 0.0);
            }      }
            else {    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
             for(m=firstpass; m<=lastpass; m++){    for(h=1; h <=nhstepm; h++){
              k2=anint[m][i]+(mint[m][i]/12.);      for(d=1; d <=hstepm; d++){
              if ((k2>=dateprev1) && (k2<=dateprev2)) {        newm=savm;
              if(agev[m][i]==0) agev[m][i]=agemax+1;        /* Covariates have to be included here again */
              if(agev[m][i]==1) agev[m][i]=agemax+2;        cov[1]=1.;
              freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];        cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;
              freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];        for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
              }        for (k=1; k<=cptcovage;k++)
             }          cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
            }        for (k=1; k<=cptcovprod;k++)
           }          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
        }  
         if  (cptcovn>0) {  
          fprintf(ficresp, "\n#********** Variable ");        /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/
          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);        /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/
        fprintf(ficresp, "**********\n#");        out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, 
         }                     pmij(pmmij,cov,ncovmodel,x,nlstate));
        for(i=1; i<=nlstate;i++)        savm=oldm;
          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);        oldm=newm;
        fprintf(ficresp, "\n");      }
              for(i=1; i<=nlstate+ndeath; i++)
   for(i=(int)agemin; i <= (int)agemax+3; i++){        for(j=1;j<=nlstate+ndeath;j++) {
     if(i==(int)agemax+3)          po[i][j][h]=newm[i][j];
       printf("Total");          /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);
     else           */
       printf("Age %d", i);        }
     for(jk=1; jk <=nlstate ; jk++){    } /* end h */
       for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)    return po;
         pp[jk] += freq[jk][m][i];  }
     }  
     for(jk=1; jk <=nlstate ; jk++){  
       for(m=-1, pos=0; m <=0 ; m++)  /*************** log-likelihood *************/
         pos += freq[jk][m][i];  double func( double *x)
       if(pp[jk]>=1.e-10)  {
         printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);    int i, ii, j, k, mi, d, kk;
       else    double l, ll[NLSTATEMAX], cov[NCOVMAX];
         printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);    double **out;
     }    double sw; /* Sum of weights */
     double lli; /* Individual log likelihood */
      for(jk=1; jk <=nlstate ; jk++){    int s1, s2;
       for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)    double bbh, survp;
         pp[jk] += freq[jk][m][i];    long ipmx;
      }    /*extern weight */
     /* We are differentiating ll according to initial status */
     for(jk=1,pos=0; jk <=nlstate ; jk++)    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
       pos += pp[jk];    /*for(i=1;i<imx;i++) 
     for(jk=1; jk <=nlstate ; jk++){      printf(" %d\n",s[4][i]);
       if(pos>=1.e-5)    */
         printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);    cov[1]=1.;
       else  
         printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);    for(k=1; k<=nlstate; k++) ll[k]=0.;
       if( i <= (int) agemax){  
         if(pos>=1.e-5){    if(mle==1){
           fprintf(ficresp," %d %.5f %.0f %.0f",i,pp[jk]/pos, pp[jk],pos);      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
           probs[i][jk][j1]= pp[jk]/pos;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
           /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/        for(mi=1; mi<= wav[i]-1; mi++){
         }          for (ii=1;ii<=nlstate+ndeath;ii++)
       else            for (j=1;j<=nlstate+ndeath;j++){
           fprintf(ficresp," %d NaNq %.0f %.0f",i,pp[jk],pos);              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       }              savm[ii][j]=(ii==j ? 1.0 : 0.0);
     }            }
     for(jk=-1; jk <=nlstate+ndeath; jk++)          for(d=0; d<dh[mi][i]; d++){
       for(m=-1; m <=nlstate+ndeath; m++)            newm=savm;
         if(freq[jk][m][i] !=0 ) printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     if(i <= (int) agemax)            for (kk=1; kk<=cptcovage;kk++) {
       fprintf(ficresp,"\n");              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
     printf("\n");            }
     }            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     }                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
  }            savm=oldm;
              oldm=newm;
   fclose(ficresp);          } /* end mult */
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);        
   free_vector(pp,1,nlstate);          /*lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/ /* Original formula */
           /* But now since version 0.9 we anticipate for bias at large stepm.
 }  /* End of Freq */           * If stepm is larger than one month (smallest stepm) and if the exact delay 
            * (in months) between two waves is not a multiple of stepm, we rounded to 
 /************ Prevalence ********************/           * the nearest (and in case of equal distance, to the lowest) interval but now
 void prevalence(int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax, int fprev1,int lprev1, double **mint,double **anint,int boolprev, double dateprev1, double dateprev2)           * we keep into memory the bias bh[mi][i] and also the previous matrix product
 {  /* Some frequencies */           * (i.e to dh[mi][i]-1) saved in 'savm'. Then we inter(extra)polate the
             * probability in order to take into account the bias as a fraction of the way
   int i, m, jk, k1, i1, j1, bool, z1,z2,j;           * from savm to out if bh is negative or even beyond if bh is positive. bh varies
   double ***freq; /* Frequencies */           * -stepm/2 to stepm/2 .
   double *pp;           * For stepm=1 the results are the same as for previous versions of Imach.
   double pos, k2;           * For stepm > 1 the results are less biased than in previous versions. 
            */
   pp=vector(1,nlstate);          s1=s[mw[mi][i]][i];
   probs= ma3x(1,130 ,1,8, 1,8);          s2=s[mw[mi+1][i]][i];
            bbh=(double)bh[mi][i]/(double)stepm; 
   freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);          /* bias bh is positive if real duration
   j1=0;           * is higher than the multiple of stepm and negative otherwise.
             */
   j=cptcoveff;          /* lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2]));*/
   if (cptcovn<1) {j=1;ncodemax[1]=1;}          if( s2 > nlstate){ 
              /* i.e. if s2 is a death state and if the date of death is known 
  for(k1=1; k1<=j;k1++){               then the contribution to the likelihood is the probability to 
     for(i1=1; i1<=ncodemax[k1];i1++){               die between last step unit time and current  step unit time, 
       j1++;               which is also equal to probability to die before dh 
                 minus probability to die before dh-stepm . 
       for (i=-1; i<=nlstate+ndeath; i++)                 In version up to 0.92 likelihood was computed
         for (jk=-1; jk<=nlstate+ndeath; jk++)            as if date of death was unknown. Death was treated as any other
           for(m=agemin; m <= agemax+3; m++)          health state: the date of the interview describes the actual state
           freq[i][jk][m]=0;          and not the date of a change in health state. The former idea was
                to consider that at each interview the state was recorded
       for (i=1; i<=imx; i++) {          (healthy, disable or death) and IMaCh was corrected; but when we
         bool=1;          introduced the exact date of death then we should have modified
         if  (cptcovn>0) {          the contribution of an exact death to the likelihood. This new
           for (z1=1; z1<=cptcoveff; z1++)          contribution is smaller and very dependent of the step unit
             if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]])          stepm. It is no more the probability to die between last interview
               bool=0;          and month of death but the probability to survive from last
               }          interview up to one month before death multiplied by the
         if (bool==1) {          probability to die within a month. Thanks to Chris
           if (boolprev==1){          Jackson for correcting this bug.  Former versions increased
             for(m=fprev1; m<=lprev1; m++){          mortality artificially. The bad side is that we add another loop
               if(agev[m][i]==0) agev[m][i]=agemax+1;          which slows down the processing. The difference can be up to 10%
               if(agev[m][i]==1) agev[m][i]=agemax+2;          lower mortality.
               freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];            */
               freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];            lli=log(out[s1][s2] - savm[s1][s2]);
             }  
           }  
           else {          } else if  (s2==-2) {
             for(m=firstpass; m<=lastpass; m++){            for (j=1,survp=0. ; j<=nlstate; j++) 
               k2=anint[m][i]+(mint[m][i]/12.);              survp += out[s1][j];
               if ((k2>=dateprev1) && (k2<=dateprev2)) {            lli= survp;
                 if(agev[m][i]==0) agev[m][i]=agemax+1;          }
                 if(agev[m][i]==1) agev[m][i]=agemax+2;          
                 freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];          else if  (s2==-4) {
                 freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];            for (j=3,survp=0. ; j<=nlstate; j++) 
               }              survp += out[s1][j];
             }            lli= survp;
           }          }
         }          
       }          else if  (s2==-5) {
         for(i=(int)agemin; i <= (int)agemax+3; i++){            for (j=1,survp=0. ; j<=2; j++) 
           for(jk=1; jk <=nlstate ; jk++){              survp += out[s1][j];
             for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)            lli= survp;
               pp[jk] += freq[jk][m][i];          }
           }  
           for(jk=1; jk <=nlstate ; jk++){  
             for(m=-1, pos=0; m <=0 ; m++)          else{
             pos += freq[jk][m][i];            lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
         }            /*  lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2]));*/ /* linear interpolation */
                  } 
          for(jk=1; jk <=nlstate ; jk++){          /*lli=(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]);*/
            for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)          /*if(lli ==000.0)*/
              pp[jk] += freq[jk][m][i];          /*printf("bbh= %f lli=%f savm=%f out=%f %d\n",bbh,lli,savm[s1][s2], out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]],i); */
          }          ipmx +=1;
                    sw += weight[i];
          for(jk=1,pos=0; jk <=nlstate ; jk++) pos += pp[jk];          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         } /* end of wave */
          for(jk=1; jk <=nlstate ; jk++){                } /* end of individual */
            if( i <= (int) agemax){    }  else if(mle==2){
              if(pos>=1.e-5){      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
                probs[i][jk][j1]= pp[jk]/pos;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
              }        for(mi=1; mi<= wav[i]-1; mi++){
            }          for (ii=1;ii<=nlstate+ndeath;ii++)
          }            for (j=1;j<=nlstate+ndeath;j++){
                        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
         }              savm[ii][j]=(ii==j ? 1.0 : 0.0);
     }            }
   }          for(d=0; d<=dh[mi][i]; d++){
              newm=savm;
              cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);            for (kk=1; kk<=cptcovage;kk++) {
   free_vector(pp,1,nlstate);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
              }
 }  /* End of Freq */            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
 /************* Waves Concatenation ***************/                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
             savm=oldm;
 void  concatwav(int wav[], int **dh, int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)            oldm=newm;
 {          } /* end mult */
   /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.        
      Death is a valid wave (if date is known).          s1=s[mw[mi][i]][i];
      mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i          s2=s[mw[mi+1][i]][i];
      dh[m][i] of dh[mw[mi][i][i] is the delay between two effective waves m=mw[mi][i]          bbh=(double)bh[mi][i]/(double)stepm; 
      and mw[mi+1][i]. dh depends on stepm.          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
      */          ipmx +=1;
           sw += weight[i];
   int i, mi, m;          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;        } /* end of wave */
      double sum=0., jmean=0.;*/      } /* end of individual */
     }  else if(mle==3){  /* exponential inter-extrapolation */
   int j, k=0,jk, ju, jl;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
   double sum=0.;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   jmin=1e+5;        for(mi=1; mi<= wav[i]-1; mi++){
   jmax=-1;          for (ii=1;ii<=nlstate+ndeath;ii++)
   jmean=0.;            for (j=1;j<=nlstate+ndeath;j++){
   for(i=1; i<=imx; i++){              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     mi=0;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
     m=firstpass;            }
     while(s[m][i] <= nlstate){          for(d=0; d<dh[mi][i]; d++){
       if(s[m][i]>=1)            newm=savm;
         mw[++mi][i]=m;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
       if(m >=lastpass)            for (kk=1; kk<=cptcovage;kk++) {
         break;              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       else            }
         m++;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     }/* end while */                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
     if (s[m][i] > nlstate){            savm=oldm;
       mi++;     /* Death is another wave */            oldm=newm;
       /* if(mi==0)  never been interviewed correctly before death */          } /* end mult */
          /* Only death is a correct wave */        
       mw[mi][i]=m;          s1=s[mw[mi][i]][i];
     }          s2=s[mw[mi+1][i]][i];
           bbh=(double)bh[mi][i]/(double)stepm; 
     wav[i]=mi;          lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
     if(mi==0)          ipmx +=1;
       printf("Warning, no any valid information for:%d line=%d\n",num[i],i);          sw += weight[i];
   }          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         } /* end of wave */
   for(i=1; i<=imx; i++){      } /* end of individual */
     for(mi=1; mi<wav[i];mi++){    }else if (mle==4){  /* ml=4 no inter-extrapolation */
       if (stepm <=0)      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         dh[mi][i]=1;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
       else{        for(mi=1; mi<= wav[i]-1; mi++){
         if (s[mw[mi+1][i]][i] > nlstate) {          for (ii=1;ii<=nlstate+ndeath;ii++)
           if (agedc[i] < 2*AGESUP) {            for (j=1;j<=nlstate+ndeath;j++){
           j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12);              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
           if(j==0) j=1;  /* Survives at least one month after exam */              savm[ii][j]=(ii==j ? 1.0 : 0.0);
           k=k+1;            }
           if (j >= jmax) jmax=j;          for(d=0; d<dh[mi][i]; d++){
           if (j <= jmin) jmin=j;            newm=savm;
           sum=sum+j;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
           /* if (j<10) printf("j=%d num=%d ",j,i); */            for (kk=1; kk<=cptcovage;kk++) {
           }              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
         }            }
         else{          
           j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
           k=k+1;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
           if (j >= jmax) jmax=j;            savm=oldm;
           else if (j <= jmin)jmin=j;            oldm=newm;
           /*   if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */          } /* end mult */
           sum=sum+j;        
         }          s1=s[mw[mi][i]][i];
         jk= j/stepm;          s2=s[mw[mi+1][i]][i];
         jl= j -jk*stepm;          if( s2 > nlstate){ 
         ju= j -(jk+1)*stepm;            lli=log(out[s1][s2] - savm[s1][s2]);
         if(jl <= -ju)          }else{
           dh[mi][i]=jk;            lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
         else          }
           dh[mi][i]=jk+1;          ipmx +=1;
         if(dh[mi][i]==0)          sw += weight[i];
           dh[mi][i]=1; /* At least one step */          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       }  /*      printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
     }        } /* end of wave */
   }      } /* end of individual */
   jmean=sum/k;    }else{  /* ml=5 no inter-extrapolation no jackson =0.8a */
   printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
  }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
 /*********** Tricode ****************************/        for(mi=1; mi<= wav[i]-1; mi++){
 void tricode(int *Tvar, int **nbcode, int imx)          for (ii=1;ii<=nlstate+ndeath;ii++)
 {            for (j=1;j<=nlstate+ndeath;j++){
   int Ndum[20],ij=1, k, j, i;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   int cptcode=0;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
   cptcoveff=0;            }
            for(d=0; d<dh[mi][i]; d++){
   for (k=0; k<19; k++) Ndum[k]=0;            newm=savm;
   for (k=1; k<=7; k++) ncodemax[k]=0;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
             for (kk=1; kk<=cptcovage;kk++) {
   for (j=1; j<=(cptcovn+2*cptcovprod); j++) {              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
     for (i=1; i<=imx; i++) {            }
       ij=(int)(covar[Tvar[j]][i]);          
       Ndum[ij]++;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
       /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       if (ij > cptcode) cptcode=ij;            savm=oldm;
     }            oldm=newm;
           } /* end mult */
     for (i=0; i<=cptcode; i++) {        
       if(Ndum[i]!=0) ncodemax[j]++;          s1=s[mw[mi][i]][i];
     }          s2=s[mw[mi+1][i]][i];
     ij=1;          lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
           ipmx +=1;
           sw += weight[i];
     for (i=1; i<=ncodemax[j]; i++) {          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       for (k=0; k<=19; k++) {          /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]);*/
         if (Ndum[k] != 0) {        } /* end of wave */
           nbcode[Tvar[j]][ij]=k;      } /* end of individual */
           ij++;    } /* End of if */
         }    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
         if (ij > ncodemax[j]) break;    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
       }      l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
     }    return -l;
   }    }
   
  for (k=0; k<19; k++) Ndum[k]=0;  /*************** log-likelihood *************/
   double funcone( double *x)
  for (i=1; i<=ncovmodel-2; i++) {  {
       ij=Tvar[i];    /* Same as likeli but slower because of a lot of printf and if */
       Ndum[ij]++;    int i, ii, j, k, mi, d, kk;
     }    double l, ll[NLSTATEMAX], cov[NCOVMAX];
     double **out;
  ij=1;    double lli; /* Individual log likelihood */
  for (i=1; i<=10; i++) {    double llt;
    if((Ndum[i]!=0) && (i<=ncov)){    int s1, s2;
      Tvaraff[ij]=i;    double bbh, survp;
      ij++;    /*extern weight */
    }    /* We are differentiating ll according to initial status */
  }    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
      /*for(i=1;i<imx;i++) 
     cptcoveff=ij-1;      printf(" %d\n",s[4][i]);
 }    */
     cov[1]=1.;
 /*********** Health Expectancies ****************/  
     for(k=1; k<=nlstate; k++) ll[k]=0.;
 void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij)  
 {    for (i=1,ipmx=0, sw=0.; i<=imx; i++){
   /* Health expectancies */      for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   int i, j, nhstepm, hstepm, h;      for(mi=1; mi<= wav[i]-1; mi++){
   double age, agelim,hf;        for (ii=1;ii<=nlstate+ndeath;ii++)
   double ***p3mat;          for (j=1;j<=nlstate+ndeath;j++){
              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   fprintf(ficreseij,"# Health expectancies\n");            savm[ii][j]=(ii==j ? 1.0 : 0.0);
   fprintf(ficreseij,"# Age");          }
   for(i=1; i<=nlstate;i++)        for(d=0; d<dh[mi][i]; d++){
     for(j=1; j<=nlstate;j++)          newm=savm;
       fprintf(ficreseij," %1d-%1d",i,j);          cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   fprintf(ficreseij,"\n");          for (kk=1; kk<=cptcovage;kk++) {
             cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
   hstepm=1*YEARM; /*  Every j years of age (in month) */          }
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */          out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
                        1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   agelim=AGESUP;          savm=oldm;
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */          oldm=newm;
     /* nhstepm age range expressed in number of stepm */        } /* end mult */
     nhstepm=(int) rint((agelim-age)*YEARM/stepm);        
     /* Typically if 20 years = 20*12/6=40 stepm */        s1=s[mw[mi][i]][i];
     if (stepm >= YEARM) hstepm=1;        s2=s[mw[mi+1][i]][i];
     nhstepm = nhstepm/hstepm;/* Expressed in hstepm, typically 40/4=10 */        bbh=(double)bh[mi][i]/(double)stepm; 
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);        /* bias is positive if real duration
     /* Computed by stepm unit matrices, product of hstepm matrices, stored         * is higher than the multiple of stepm and negative otherwise.
        in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */         */
     hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);          if( s2 > nlstate && (mle <5) ){  /* Jackson */
           lli=log(out[s1][s2] - savm[s1][s2]);
         } else if (mle==1){
     for(i=1; i<=nlstate;i++)          lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
       for(j=1; j<=nlstate;j++)        } else if(mle==2){
         for (h=0, eij[i][j][(int)age]=0; h<=nhstepm; h++){          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
           eij[i][j][(int)age] +=p3mat[i][j][h];        } else if(mle==3){  /* exponential inter-extrapolation */
         }          lli= (savm[s1][s2]>(double)1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
            } else if (mle==4){  /* mle=4 no inter-extrapolation */
     hf=1;          lli=log(out[s1][s2]); /* Original formula */
     if (stepm >= YEARM) hf=stepm/YEARM;        } else{  /* ml>=5 no inter-extrapolation no jackson =0.8a */
     fprintf(ficreseij,"%.0f",age );          lli=log(out[s1][s2]); /* Original formula */
     for(i=1; i<=nlstate;i++)        } /* End of if */
       for(j=1; j<=nlstate;j++){        ipmx +=1;
         fprintf(ficreseij," %.4f", hf*eij[i][j][(int)age]);        sw += weight[i];
       }        ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
     fprintf(ficreseij,"\n");  /*       printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);        if(globpr){
   }          fprintf(ficresilk,"%9d %6d %1d %1d %1d %1d %3d %10.6f %6.4f\
 }   %10.6f %10.6f %10.6f ", \
                   num[i],i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],
 /************ Variance ******************/                  2*weight[i]*lli,out[s1][s2],savm[s1][s2]);
 void varevsij(char fileres[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)          for(k=1,llt=0.,l=0.; k<=nlstate; k++){
 {            llt +=ll[k]*gipmx/gsw;
   /* Variance of health expectancies */            fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw);
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/          }
   double **newm;          fprintf(ficresilk," %10.6f\n", -llt);
   double **dnewm,**doldm;        }
   int i, j, nhstepm, hstepm, h;      } /* end of wave */
   int k, cptcode;    } /* end of individual */
   double *xp;    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
   double **gp, **gm;    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
   double ***gradg, ***trgradg;    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
   double ***p3mat;    if(globpr==0){ /* First time we count the contributions and weights */
   double age,agelim;      gipmx=ipmx;
   int theta;      gsw=sw;
     }
    fprintf(ficresvij,"# Covariances of life expectancies\n");    return -l;
   fprintf(ficresvij,"# Age");  }
   for(i=1; i<=nlstate;i++)  
     for(j=1; j<=nlstate;j++)  
       fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);  /*************** function likelione ***********/
   fprintf(ficresvij,"\n");  void likelione(FILE *ficres,double p[], int npar, int nlstate, int *globpri, long *ipmx, double *sw, double *fretone, double (*funcone)(double []))
   {
   xp=vector(1,npar);    /* This routine should help understanding what is done with 
   dnewm=matrix(1,nlstate,1,npar);       the selection of individuals/waves and
   doldm=matrix(1,nlstate,1,nlstate);       to check the exact contribution to the likelihood.
         Plotting could be done.
   hstepm=1*YEARM; /* Every year of age */     */
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */    int k;
   agelim = AGESUP;  
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */    if(*globpri !=0){ /* Just counts and sums, no printings */
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */      strcpy(fileresilk,"ilk"); 
     if (stepm >= YEARM) hstepm=1;      strcat(fileresilk,fileres);
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */      if((ficresilk=fopen(fileresilk,"w"))==NULL) {
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);        printf("Problem with resultfile: %s\n", fileresilk);
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate);        fprintf(ficlog,"Problem with resultfile: %s\n", fileresilk);
     gp=matrix(0,nhstepm,1,nlstate);      }
     gm=matrix(0,nhstepm,1,nlstate);      fprintf(ficresilk, "#individual(line's_record) s1 s2 wave# effective_wave# number_of_matrices_product pij weight -2ln(pij)*weight 0pij_x 0pij_(x-stepm) cumulating_loglikeli_by_health_state(reweighted=-2ll*weightXnumber_of_contribs/sum_of_weights) and_total\n");
       fprintf(ficresilk, "#num_i i s1 s2 mi mw dh likeli weight 2wlli out sav ");
     for(theta=1; theta <=npar; theta++){      /*  i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],2*weight[i]*lli,out[s1][s2],savm[s1][s2]); */
       for(i=1; i<=npar; i++){ /* Computes gradient */      for(k=1; k<=nlstate; k++) 
         xp[i] = x[i] + (i==theta ?delti[theta]:0);        fprintf(ficresilk," -2*gipw/gsw*weight*ll[%d]++",k);
       }      fprintf(ficresilk," -2*gipw/gsw*weight*ll(total)\n");
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);      }
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);  
     *fretone=(*funcone)(p);
       if (popbased==1) {    if(*globpri !=0){
         for(i=1; i<=nlstate;i++)      fclose(ficresilk);
           prlim[i][i]=probs[(int)age][i][ij];      fprintf(fichtm,"\n<br>File of contributions to the likelihood: <a href=\"%s\">%s</a><br>\n",subdirf(fileresilk),subdirf(fileresilk));
       }      fflush(fichtm); 
          } 
       for(j=1; j<= nlstate; j++){    return;
         for(h=0; h<=nhstepm; h++){  }
           for(i=1, gp[h][j]=0.;i<=nlstate;i++)  
             gp[h][j] += prlim[i][i]*p3mat[i][j][h];  
         }  /*********** Maximum Likelihood Estimation ***************/
       }  
      void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))
       for(i=1; i<=npar; i++) /* Computes gradient */  {
         xp[i] = x[i] - (i==theta ?delti[theta]:0);    int i,j, iter;
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);      double **xi;
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    double fret;
     double fretone; /* Only one call to likelihood */
       if (popbased==1) {    /*  char filerespow[FILENAMELENGTH];*/
         for(i=1; i<=nlstate;i++)    xi=matrix(1,npar,1,npar);
           prlim[i][i]=probs[(int)age][i][ij];    for (i=1;i<=npar;i++)
       }      for (j=1;j<=npar;j++)
         xi[i][j]=(i==j ? 1.0 : 0.0);
       for(j=1; j<= nlstate; j++){    printf("Powell\n");  fprintf(ficlog,"Powell\n");
         for(h=0; h<=nhstepm; h++){    strcpy(filerespow,"pow"); 
           for(i=1, gm[h][j]=0.;i<=nlstate;i++)    strcat(filerespow,fileres);
             gm[h][j] += prlim[i][i]*p3mat[i][j][h];    if((ficrespow=fopen(filerespow,"w"))==NULL) {
         }      printf("Problem with resultfile: %s\n", filerespow);
       }      fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
     }
       for(j=1; j<= nlstate; j++)    fprintf(ficrespow,"# Powell\n# iter -2*LL");
         for(h=0; h<=nhstepm; h++){    for (i=1;i<=nlstate;i++)
           gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];      for(j=1;j<=nlstate+ndeath;j++)
         }        if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
     } /* End theta */    fprintf(ficrespow,"\n");
   
     trgradg =ma3x(0,nhstepm,1,nlstate,1,npar);    powell(p,xi,npar,ftol,&iter,&fret,func);
   
     for(h=0; h<=nhstepm; h++)    fclose(ficrespow);
       for(j=1; j<=nlstate;j++)    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));
         for(theta=1; theta <=npar; theta++)    fprintf(ficlog,"\n#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
           trgradg[h][j][theta]=gradg[h][theta][j];    fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
   
     for(i=1;i<=nlstate;i++)  }
       for(j=1;j<=nlstate;j++)  
         vareij[i][j][(int)age] =0.;  /**** Computes Hessian and covariance matrix ***/
     for(h=0;h<=nhstepm;h++){  void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))
       for(k=0;k<=nhstepm;k++){  {
         matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);    double  **a,**y,*x,pd;
         matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);    double **hess;
         for(i=1;i<=nlstate;i++)    int i, j,jk;
           for(j=1;j<=nlstate;j++)    int *indx;
             vareij[i][j][(int)age] += doldm[i][j];  
       }    double hessii(double p[], double delta, int theta, double delti[],double (*func)(double []),int npar);
     }    double hessij(double p[], double delti[], int i, int j,double (*func)(double []),int npar);
     h=1;    void lubksb(double **a, int npar, int *indx, double b[]) ;
     if (stepm >= YEARM) h=stepm/YEARM;    void ludcmp(double **a, int npar, int *indx, double *d) ;
     fprintf(ficresvij,"%.0f ",age );    double gompertz(double p[]);
     for(i=1; i<=nlstate;i++)    hess=matrix(1,npar,1,npar);
       for(j=1; j<=nlstate;j++){  
         fprintf(ficresvij," %.4f", h*vareij[i][j][(int)age]);    printf("\nCalculation of the hessian matrix. Wait...\n");
       }    fprintf(ficlog,"\nCalculation of the hessian matrix. Wait...\n");
     fprintf(ficresvij,"\n");    for (i=1;i<=npar;i++){
     free_matrix(gp,0,nhstepm,1,nlstate);      printf("%d",i);fflush(stdout);
     free_matrix(gm,0,nhstepm,1,nlstate);      fprintf(ficlog,"%d",i);fflush(ficlog);
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);     
     free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);       hess[i][i]=hessii(p,ftolhess,i,delti,func,npar);
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);      
   } /* End age */      /*  printf(" %f ",p[i]);
            printf(" %lf %lf %lf",hess[i][i],ftolhess,delti[i]);*/
   free_vector(xp,1,npar);    }
   free_matrix(doldm,1,nlstate,1,npar);    
   free_matrix(dnewm,1,nlstate,1,nlstate);    for (i=1;i<=npar;i++) {
       for (j=1;j<=npar;j++)  {
 }        if (j>i) { 
           printf(".%d%d",i,j);fflush(stdout);
 /************ Variance of prevlim ******************/          fprintf(ficlog,".%d%d",i,j);fflush(ficlog);
 void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)          hess[i][j]=hessij(p,delti,i,j,func,npar);
 {          
   /* Variance of prevalence limit */          hess[j][i]=hess[i][j];    
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/          /*printf(" %lf ",hess[i][j]);*/
   double **newm;        }
   double **dnewm,**doldm;      }
   int i, j, nhstepm, hstepm;    }
   int k, cptcode;    printf("\n");
   double *xp;    fprintf(ficlog,"\n");
   double *gp, *gm;  
   double **gradg, **trgradg;    printf("\nInverting the hessian to get the covariance matrix. Wait...\n");
   double age,agelim;    fprintf(ficlog,"\nInverting the hessian to get the covariance matrix. Wait...\n");
   int theta;    
        a=matrix(1,npar,1,npar);
   fprintf(ficresvpl,"# Standard deviation of prevalences limit\n");    y=matrix(1,npar,1,npar);
   fprintf(ficresvpl,"# Age");    x=vector(1,npar);
   for(i=1; i<=nlstate;i++)    indx=ivector(1,npar);
       fprintf(ficresvpl," %1d-%1d",i,i);    for (i=1;i<=npar;i++)
   fprintf(ficresvpl,"\n");      for (j=1;j<=npar;j++) a[i][j]=hess[i][j];
     ludcmp(a,npar,indx,&pd);
   xp=vector(1,npar);  
   dnewm=matrix(1,nlstate,1,npar);    for (j=1;j<=npar;j++) {
   doldm=matrix(1,nlstate,1,nlstate);      for (i=1;i<=npar;i++) x[i]=0;
        x[j]=1;
   hstepm=1*YEARM; /* Every year of age */      lubksb(a,npar,indx,x);
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */      for (i=1;i<=npar;i++){ 
   agelim = AGESUP;        matcov[i][j]=x[i];
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */      }
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */    }
     if (stepm >= YEARM) hstepm=1;  
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */    printf("\n#Hessian matrix#\n");
     gradg=matrix(1,npar,1,nlstate);    fprintf(ficlog,"\n#Hessian matrix#\n");
     gp=vector(1,nlstate);    for (i=1;i<=npar;i++) { 
     gm=vector(1,nlstate);      for (j=1;j<=npar;j++) { 
         printf("%.3e ",hess[i][j]);
     for(theta=1; theta <=npar; theta++){        fprintf(ficlog,"%.3e ",hess[i][j]);
       for(i=1; i<=npar; i++){ /* Computes gradient */      }
         xp[i] = x[i] + (i==theta ?delti[theta]:0);      printf("\n");
       }      fprintf(ficlog,"\n");
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    }
       for(i=1;i<=nlstate;i++)  
         gp[i] = prlim[i][i];    /* Recompute Inverse */
        for (i=1;i<=npar;i++)
       for(i=1; i<=npar; i++) /* Computes gradient */      for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];
         xp[i] = x[i] - (i==theta ?delti[theta]:0);    ludcmp(a,npar,indx,&pd);
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);  
       for(i=1;i<=nlstate;i++)    /*  printf("\n#Hessian matrix recomputed#\n");
         gm[i] = prlim[i][i];  
     for (j=1;j<=npar;j++) {
       for(i=1;i<=nlstate;i++)      for (i=1;i<=npar;i++) x[i]=0;
         gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];      x[j]=1;
     } /* End theta */      lubksb(a,npar,indx,x);
       for (i=1;i<=npar;i++){ 
     trgradg =matrix(1,nlstate,1,npar);        y[i][j]=x[i];
         printf("%.3e ",y[i][j]);
     for(j=1; j<=nlstate;j++)        fprintf(ficlog,"%.3e ",y[i][j]);
       for(theta=1; theta <=npar; theta++)      }
         trgradg[j][theta]=gradg[theta][j];      printf("\n");
       fprintf(ficlog,"\n");
     for(i=1;i<=nlstate;i++)    }
       varpl[i][(int)age] =0.;    */
     matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);  
     matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);    free_matrix(a,1,npar,1,npar);
     for(i=1;i<=nlstate;i++)    free_matrix(y,1,npar,1,npar);
       varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */    free_vector(x,1,npar);
     free_ivector(indx,1,npar);
     fprintf(ficresvpl,"%.0f ",age );    free_matrix(hess,1,npar,1,npar);
     for(i=1; i<=nlstate;i++)  
       fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));  
     fprintf(ficresvpl,"\n");  }
     free_vector(gp,1,nlstate);  
     free_vector(gm,1,nlstate);  /*************** hessian matrix ****************/
     free_matrix(gradg,1,npar,1,nlstate);  double hessii(double x[], double delta, int theta, double delti[], double (*func)(double []), int npar)
     free_matrix(trgradg,1,nlstate,1,npar);  {
   } /* End age */    int i;
     int l=1, lmax=20;
   free_vector(xp,1,npar);    double k1,k2;
   free_matrix(doldm,1,nlstate,1,npar);    double p2[NPARMAX+1];
   free_matrix(dnewm,1,nlstate,1,nlstate);    double res;
     double delt=0.0001, delts, nkhi=10.,nkhif=1., khi=1.e-4;
 }    double fx;
     int k=0,kmax=10;
 /************ Variance of one-step probabilities  ******************/    double l1;
 void varprob(char fileres[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij)  
 {    fx=func(x);
   int i, j;    for (i=1;i<=npar;i++) p2[i]=x[i];
   int k=0, cptcode;    for(l=0 ; l <=lmax; l++){
   double **dnewm,**doldm;      l1=pow(10,l);
   double *xp;      delts=delt;
   double *gp, *gm;      for(k=1 ; k <kmax; k=k+1){
   double **gradg, **trgradg;        delt = delta*(l1*k);
   double age,agelim, cov[NCOVMAX];        p2[theta]=x[theta] +delt;
   int theta;        k1=func(p2)-fx;
   char fileresprob[FILENAMELENGTH];        p2[theta]=x[theta]-delt;
         k2=func(p2)-fx;
   strcpy(fileresprob,"prob");        /*res= (k1-2.0*fx+k2)/delt/delt; */
   strcat(fileresprob,fileres);        res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */
   if((ficresprob=fopen(fileresprob,"w"))==NULL) {        
     printf("Problem with resultfile: %s\n", fileresprob);  #ifdef DEBUG
   }        printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
   printf("Computing variance of one-step probabilities: result on file '%s' \n",fileresprob);        fprintf(ficlog,"%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
    #endif
         /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */
   xp=vector(1,npar);        if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){
   dnewm=matrix(1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);          k=kmax;
   doldm=matrix(1,(nlstate+ndeath)*(nlstate+ndeath),1,(nlstate+ndeath)*(nlstate+ndeath));        }
          else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */
   cov[1]=1;          k=kmax; l=lmax*10.;
   for (age=bage; age<=fage; age ++){        }
     cov[2]=age;        else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){ 
     gradg=matrix(1,npar,1,9);          delts=delt;
     trgradg=matrix(1,9,1,npar);        }
     gp=vector(1,(nlstate+ndeath)*(nlstate+ndeath));      }
     gm=vector(1,(nlstate+ndeath)*(nlstate+ndeath));    }
        delti[theta]=delts;
     for(theta=1; theta <=npar; theta++){    return res; 
       for(i=1; i<=npar; i++)    
         xp[i] = x[i] + (i==theta ?delti[theta]:0);  }
        
       pmij(pmmij,cov,ncovmodel,xp,nlstate);  double hessij( double x[], double delti[], int thetai,int thetaj,double (*func)(double []),int npar)
      {
       k=0;    int i;
       for(i=1; i<= (nlstate+ndeath); i++){    int l=1, l1, lmax=20;
         for(j=1; j<=(nlstate+ndeath);j++){    double k1,k2,k3,k4,res,fx;
            k=k+1;    double p2[NPARMAX+1];
           gp[k]=pmmij[i][j];    int k;
         }  
       }    fx=func(x);
     for (k=1; k<=2; k++) {
       for(i=1; i<=npar; i++)      for (i=1;i<=npar;i++) p2[i]=x[i];
         xp[i] = x[i] - (i==theta ?delti[theta]:0);      p2[thetai]=x[thetai]+delti[thetai]/k;
          p2[thetaj]=x[thetaj]+delti[thetaj]/k;
       k1=func(p2)-fx;
       pmij(pmmij,cov,ncovmodel,xp,nlstate);    
       k=0;      p2[thetai]=x[thetai]+delti[thetai]/k;
       for(i=1; i<=(nlstate+ndeath); i++){      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
         for(j=1; j<=(nlstate+ndeath);j++){      k2=func(p2)-fx;
           k=k+1;    
           gm[k]=pmmij[i][j];      p2[thetai]=x[thetai]-delti[thetai]/k;
         }      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
       }      k3=func(p2)-fx;
          
        for(i=1; i<= (nlstate+ndeath)*(nlstate+ndeath); i++)      p2[thetai]=x[thetai]-delti[thetai]/k;
            gradg[theta][i]=(gp[i]-gm[i])/2./delti[theta];        p2[thetaj]=x[thetaj]-delti[thetaj]/k;
     }      k4=func(p2)-fx;
       res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */
      for(j=1; j<=(nlstate+ndeath)*(nlstate+ndeath);j++)  #ifdef DEBUG
       for(theta=1; theta <=npar; theta++)      printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
       trgradg[j][theta]=gradg[theta][j];      fprintf(ficlog,"%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
    #endif
      matprod2(dnewm,trgradg,1,9,1,npar,1,npar,matcov);    }
      matprod2(doldm,dnewm,1,9,1,npar,1,9,gradg);    return res;
   }
      pmij(pmmij,cov,ncovmodel,x,nlstate);  
   /************** Inverse of matrix **************/
      k=0;  void ludcmp(double **a, int n, int *indx, double *d) 
      for(i=1; i<=(nlstate+ndeath); i++){  { 
        for(j=1; j<=(nlstate+ndeath);j++){    int i,imax,j,k; 
          k=k+1;    double big,dum,sum,temp; 
          gm[k]=pmmij[i][j];    double *vv; 
         }   
      }    vv=vector(1,n); 
          *d=1.0; 
      /*printf("\n%d ",(int)age);    for (i=1;i<=n;i++) { 
      for (i=1; i<=(nlstate+ndeath)*(nlstate+ndeath-1);i++){      big=0.0; 
              for (j=1;j<=n;j++) 
         if ((temp=fabs(a[i][j])) > big) big=temp; 
        printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));      if (big == 0.0) nrerror("Singular matrix in routine ludcmp"); 
      }*/      vv[i]=1.0/big; 
     } 
   fprintf(ficresprob,"\n%d ",(int)age);    for (j=1;j<=n;j++) { 
       for (i=1;i<j;i++) { 
   for (i=1; i<=(nlstate+ndeath)*(nlstate+ndeath-1);i++){        sum=a[i][j]; 
     if (i== 2) fprintf(ficresprob,"%.3e %.3e ",gm[i],doldm[i][i]);        for (k=1;k<i;k++) sum -= a[i][k]*a[k][j]; 
 if (i== 4) fprintf(ficresprob,"%.3e %.3e ",gm[i],doldm[i][i]);        a[i][j]=sum; 
   }      } 
       big=0.0; 
     free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));      for (i=j;i<=n;i++) { 
     free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));        sum=a[i][j]; 
     free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);        for (k=1;k<j;k++) 
     free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);          sum -= a[i][k]*a[k][j]; 
 }        a[i][j]=sum; 
  free_vector(xp,1,npar);        if ( (dum=vv[i]*fabs(sum)) >= big) { 
 fclose(ficresprob);          big=dum; 
  exit(0);          imax=i; 
 }        } 
       } 
 /***********************************************/      if (j != imax) { 
 /**************** Main Program *****************/        for (k=1;k<=n;k++) { 
 /***********************************************/          dum=a[imax][k]; 
           a[imax][k]=a[j][k]; 
 /*int main(int argc, char *argv[])*/          a[j][k]=dum; 
 int main()        } 
 {        *d = -(*d); 
         vv[imax]=vv[j]; 
   int i,j, k, n=MAXN,iter,m,size,cptcode, cptcod;      } 
   double agedeb, agefin,hf;      indx[j]=imax; 
   double agemin=1.e20, agemax=-1.e20;      if (a[j][j] == 0.0) a[j][j]=TINY; 
       if (j != n) { 
   double fret;        dum=1.0/(a[j][j]); 
   double **xi,tmp,delta;        for (i=j+1;i<=n;i++) a[i][j] *= dum; 
       } 
   double dum; /* Dummy variable */    } 
   double ***p3mat;    free_vector(vv,1,n);  /* Doesn't work */
   int *indx;  ;
   char line[MAXLINE], linepar[MAXLINE];  } 
   char title[MAXLINE];  
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH];  void lubksb(double **a, int n, int *indx, double b[]) 
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], fileresf[FILENAMELENGTH];  { 
   char filerest[FILENAMELENGTH];    int i,ii=0,ip,j; 
   char fileregp[FILENAMELENGTH];    double sum; 
   char popfile[FILENAMELENGTH];   
   char path[80],pathc[80],pathcd[80],pathtot[80],model[20];    for (i=1;i<=n;i++) { 
   int firstobs=1, lastobs=10;      ip=indx[i]; 
   int sdeb, sfin; /* Status at beginning and end */      sum=b[ip]; 
   int c,  h , cpt,l;      b[ip]=b[i]; 
   int ju,jl, mi;      if (ii) 
   int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;        for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j]; 
   int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,**adl,*tab;      else if (sum) ii=i; 
   int mobilav=0, fprev, lprev ,fprevfore=1, lprevfore=1,nforecast,popforecast=0;      b[i]=sum; 
   int hstepm, nhstepm;    } 
   int *popage,boolprev=0;/*boolprev=0 if date and zero if wave*/    for (i=n;i>=1;i--) { 
       sum=b[i]; 
   double bage, fage, age, agelim, agebase;      for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j]; 
   double ftolpl=FTOL;      b[i]=sum/a[i][i]; 
   double **prlim;    } 
   double *severity;  } 
   double ***param; /* Matrix of parameters */  
   double  *p;  /************ Frequencies ********************/
   double **matcov; /* Matrix of covariance */  void  freqsummary(char fileres[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, int *Tvaraff, int **nbcode, int *ncodemax,double **mint,double **anint, char strstart[])
   double ***delti3; /* Scale */  {  /* Some frequencies */
   double *delti; /* Scale */    
   double ***eij, ***vareij;    int i, m, jk, k1,i1, j1, bool, z1,z2,j;
   double **varpl; /* Variances of prevalence limits by age */    int first;
   double *epj, vepp;    double ***freq; /* Frequencies */
   double kk1, kk2;    double *pp, **prop;
   double *popeffectif,*popcount;    double pos,posprop, k2, dateintsum=0,k2cpt=0;
   double dateprev1, dateprev2;    FILE *ficresp;
     char fileresp[FILENAMELENGTH];
   char version[80]="Imach version 64b, May 2001, INED-EUROREVES ";    
   char *alph[]={"a","a","b","c","d","e"}, str[4];    pp=vector(1,nlstate);
     prop=matrix(1,nlstate,iagemin,iagemax+3);
     strcpy(fileresp,"p");
   char z[1]="c", occ;    strcat(fileresp,fileres);
 #include <sys/time.h>    if((ficresp=fopen(fileresp,"w"))==NULL) {
 #include <time.h>      printf("Problem with prevalence resultfile: %s\n", fileresp);
   char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];      fprintf(ficlog,"Problem with prevalence resultfile: %s\n", fileresp);
   char strfprev[10], strlprev[10];      exit(0);
   char strfprevfore[10], strlprevfore[10];    }
   /* long total_usecs;    freq= ma3x(-5,nlstate+ndeath,-5,nlstate+ndeath,iagemin,iagemax+3);
   struct timeval start_time, end_time;    j1=0;
      
   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */    j=cptcoveff;
     if (cptcovn<1) {j=1;ncodemax[1]=1;}
   
   printf("\nIMACH, Version 0.7");    first=1;
   printf("\nEnter the parameter file name: ");  
     for(k1=1; k1<=j;k1++){
 #ifdef windows      for(i1=1; i1<=ncodemax[k1];i1++){
   scanf("%s",pathtot);        j1++;
   getcwd(pathcd, size);        /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);
   /*cygwin_split_path(pathtot,path,optionfile);          scanf("%d", i);*/
     printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/        for (i=-5; i<=nlstate+ndeath; i++)  
   /* cutv(path,optionfile,pathtot,'\\');*/          for (jk=-5; jk<=nlstate+ndeath; jk++)  
             for(m=iagemin; m <= iagemax+3; m++)
 split(pathtot, path,optionfile);              freq[i][jk][m]=0;
   chdir(path);  
   replace(pathc,path);      for (i=1; i<=nlstate; i++)  
 #endif        for(m=iagemin; m <= iagemax+3; m++)
 #ifdef unix          prop[i][m]=0;
   scanf("%s",optionfile);        
 #endif        dateintsum=0;
         k2cpt=0;
 /*-------- arguments in the command line --------*/        for (i=1; i<=imx; i++) {
           bool=1;
   strcpy(fileres,"r");          if  (cptcovn>0) {
   strcat(fileres, optionfile);            for (z1=1; z1<=cptcoveff; z1++) 
               if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
   /*---------arguments file --------*/                bool=0;
           }
   if((ficpar=fopen(optionfile,"r"))==NULL)    {          if (bool==1){
     printf("Problem with optionfile %s\n",optionfile);            for(m=firstpass; m<=lastpass; m++){
     goto end;              k2=anint[m][i]+(mint[m][i]/12.);
   }              /*if ((k2>=dateprev1) && (k2<=dateprev2)) {*/
                 if(agev[m][i]==0) agev[m][i]=iagemax+1;
   strcpy(filereso,"o");                if(agev[m][i]==1) agev[m][i]=iagemax+2;
   strcat(filereso,fileres);                if (s[m][i]>0 && s[m][i]<=nlstate) prop[s[m][i]][(int)agev[m][i]] += weight[i];
   if((ficparo=fopen(filereso,"w"))==NULL) {                if (m<lastpass) {
     printf("Problem with Output resultfile: %s\n", filereso);goto end;                  freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];
   }                  freq[s[m][i]][s[m+1][i]][iagemax+3] += weight[i];
                 }
   /* Reads comments: lines beginning with '#' */                
   while((c=getc(ficpar))=='#' && c!= EOF){                if ((agev[m][i]>1) && (agev[m][i]< (iagemax+3))) {
     ungetc(c,ficpar);                  dateintsum=dateintsum+k2;
     fgets(line, MAXLINE, ficpar);                  k2cpt++;
     puts(line);                }
     fputs(line,ficparo);                /*}*/
   }            }
   ungetc(c,ficpar);          }
         }
   fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncov, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);         
   printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate,ndeath, maxwav, mle, weightopt,model);        /*      fprintf(ficresp, "#Count between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
   fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncov,nlstate,ndeath,maxwav, mle, weightopt,model);  fprintf(ficresp, "#Local time at start: %s", strstart);
 while((c=getc(ficpar))=='#' && c!= EOF){        if  (cptcovn>0) {
     ungetc(c,ficpar);          fprintf(ficresp, "\n#********** Variable "); 
     fgets(line, MAXLINE, ficpar);          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
     puts(line);          fprintf(ficresp, "**********\n#");
     fputs(line,ficparo);        }
   }        for(i=1; i<=nlstate;i++) 
   ungetc(c,ficpar);          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);
          fprintf(ficresp, "\n");
   fscanf(ficpar,"fprevalence=%s lprevalence=%s pop_based=%d\n",strfprev,strlprev,&popbased);        
   fprintf(ficparo,"fprevalence=%s lprevalence=%s pop_based=%d\n",strfprev,strlprev,popbased);        for(i=iagemin; i <= iagemax+3; i++){
            if(i==iagemax+3){
   /* printf("%s %s",strfprev,strlprev);            fprintf(ficlog,"Total");
      exit(0);*/          }else{
  while((c=getc(ficpar))=='#' && c!= EOF){            if(first==1){
     ungetc(c,ficpar);              first=0;
     fgets(line, MAXLINE, ficpar);              printf("See log file for details...\n");
     puts(line);            }
     fputs(line,ficparo);            fprintf(ficlog,"Age %d", i);
   }          }
   ungetc(c,ficpar);          for(jk=1; jk <=nlstate ; jk++){
              for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)
   fscanf(ficpar,"fprevalence=%s lprevalence=%s nforecast=%d mob_average=%d\n",strfprevfore,strlprevfore,&nforecast,&mobilav);              pp[jk] += freq[jk][m][i]; 
   fprintf(ficparo,"fprevalence=%s lprevalence=%s nforecast=%d mob_average=%d\n",strfprevfore,strlprevfore,nforecast,mobilav);          }
                for(jk=1; jk <=nlstate ; jk++){
              for(m=-1, pos=0; m <=0 ; m++)
 while((c=getc(ficpar))=='#' && c!= EOF){              pos += freq[jk][m][i];
     ungetc(c,ficpar);            if(pp[jk]>=1.e-10){
     fgets(line, MAXLINE, ficpar);              if(first==1){
     puts(line);              printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
     fputs(line,ficparo);              }
   }              fprintf(ficlog," %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
   ungetc(c,ficpar);            }else{
                if(first==1)
   fscanf(ficpar,"popforecast=%d popfile=%s\n",&popforecast,popfile);                printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
                fprintf(ficlog," %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
   covar=matrix(0,NCOVMAX,1,n);            }
   cptcovn=0;          }
   if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;  
           for(jk=1; jk <=nlstate ; jk++){
   ncovmodel=2+cptcovn;            for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)
   nvar=ncovmodel-1; /* Suppressing age as a basic covariate */              pp[jk] += freq[jk][m][i];
            }       
   /* Read guess parameters */          for(jk=1,pos=0,posprop=0; jk <=nlstate ; jk++){
   /* Reads comments: lines beginning with '#' */            pos += pp[jk];
   while((c=getc(ficpar))=='#' && c!= EOF){            posprop += prop[jk][i];
     ungetc(c,ficpar);          }
     fgets(line, MAXLINE, ficpar);          for(jk=1; jk <=nlstate ; jk++){
     puts(line);            if(pos>=1.e-5){
     fputs(line,ficparo);              if(first==1)
   }                printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
   ungetc(c,ficpar);              fprintf(ficlog," %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
              }else{
   param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);              if(first==1)
     for(i=1; i <=nlstate; i++)                printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     for(j=1; j <=nlstate+ndeath-1; j++){              fprintf(ficlog," %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
       fscanf(ficpar,"%1d%1d",&i1,&j1);            }
       fprintf(ficparo,"%1d%1d",i1,j1);            if( i <= iagemax){
       printf("%1d%1d",i,j);              if(pos>=1.e-5){
       for(k=1; k<=ncovmodel;k++){                fprintf(ficresp," %d %.5f %.0f %.0f",i,prop[jk][i]/posprop, prop[jk][i],posprop);
         fscanf(ficpar," %lf",&param[i][j][k]);                /*probs[i][jk][j1]= pp[jk]/pos;*/
         printf(" %lf",param[i][j][k]);                /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/
         fprintf(ficparo," %lf",param[i][j][k]);              }
       }              else
       fscanf(ficpar,"\n");                fprintf(ficresp," %d NaNq %.0f %.0f",i,prop[jk][i],posprop);
       printf("\n");            }
       fprintf(ficparo,"\n");          }
     }          
            for(jk=-1; jk <=nlstate+ndeath; jk++)
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel;            for(m=-1; m <=nlstate+ndeath; m++)
               if(freq[jk][m][i] !=0 ) {
   p=param[1][1];              if(first==1)
                  printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);
   /* Reads comments: lines beginning with '#' */                fprintf(ficlog," %d%d=%.0f",jk,m,freq[jk][m][i]);
   while((c=getc(ficpar))=='#' && c!= EOF){              }
     ungetc(c,ficpar);          if(i <= iagemax)
     fgets(line, MAXLINE, ficpar);            fprintf(ficresp,"\n");
     puts(line);          if(first==1)
     fputs(line,ficparo);            printf("Others in log...\n");
   }          fprintf(ficlog,"\n");
   ungetc(c,ficpar);        }
       }
   delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);    }
   delti=vector(1,npar); /* Scale of each paramater (output from hesscov) */    dateintmean=dateintsum/k2cpt; 
   for(i=1; i <=nlstate; i++){   
     for(j=1; j <=nlstate+ndeath-1; j++){    fclose(ficresp);
       fscanf(ficpar,"%1d%1d",&i1,&j1);    free_ma3x(freq,-5,nlstate+ndeath,-5,nlstate+ndeath, iagemin, iagemax+3);
       printf("%1d%1d",i,j);    free_vector(pp,1,nlstate);
       fprintf(ficparo,"%1d%1d",i1,j1);    free_matrix(prop,1,nlstate,iagemin, iagemax+3);
       for(k=1; k<=ncovmodel;k++){    /* End of Freq */
         fscanf(ficpar,"%le",&delti3[i][j][k]);  }
         printf(" %le",delti3[i][j][k]);  
         fprintf(ficparo," %le",delti3[i][j][k]);  /************ Prevalence ********************/
       }  void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass)
       fscanf(ficpar,"\n");  {  
       printf("\n");    /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people
       fprintf(ficparo,"\n");       in each health status at the date of interview (if between dateprev1 and dateprev2).
     }       We still use firstpass and lastpass as another selection.
   }    */
   delti=delti3[1][1];   
      int i, m, jk, k1, i1, j1, bool, z1,z2,j;
   /* Reads comments: lines beginning with '#' */    double ***freq; /* Frequencies */
   while((c=getc(ficpar))=='#' && c!= EOF){    double *pp, **prop;
     ungetc(c,ficpar);    double pos,posprop; 
     fgets(line, MAXLINE, ficpar);    double  y2; /* in fractional years */
     puts(line);    int iagemin, iagemax;
     fputs(line,ficparo);  
   }    iagemin= (int) agemin;
   ungetc(c,ficpar);    iagemax= (int) agemax;
      /*pp=vector(1,nlstate);*/
   matcov=matrix(1,npar,1,npar);    prop=matrix(1,nlstate,iagemin,iagemax+3); 
   for(i=1; i <=npar; i++){    /*  freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);*/
     fscanf(ficpar,"%s",&str);    j1=0;
     printf("%s",str);    
     fprintf(ficparo,"%s",str);    j=cptcoveff;
     for(j=1; j <=i; j++){    if (cptcovn<1) {j=1;ncodemax[1]=1;}
       fscanf(ficpar," %le",&matcov[i][j]);    
       printf(" %.5le",matcov[i][j]);    for(k1=1; k1<=j;k1++){
       fprintf(ficparo," %.5le",matcov[i][j]);      for(i1=1; i1<=ncodemax[k1];i1++){
     }        j1++;
     fscanf(ficpar,"\n");        
     printf("\n");        for (i=1; i<=nlstate; i++)  
     fprintf(ficparo,"\n");          for(m=iagemin; m <= iagemax+3; m++)
   }            prop[i][m]=0.0;
   for(i=1; i <=npar; i++)       
     for(j=i+1;j<=npar;j++)        for (i=1; i<=imx; i++) { /* Each individual */
       matcov[i][j]=matcov[j][i];          bool=1;
              if  (cptcovn>0) {
   printf("\n");            for (z1=1; z1<=cptcoveff; z1++) 
               if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
                 bool=0;
     /*-------- data file ----------*/          } 
     if((ficres =fopen(fileres,"w"))==NULL) {          if (bool==1) { 
       printf("Problem with resultfile: %s\n", fileres);goto end;            for(m=firstpass; m<=lastpass; m++){/* Other selection (we can limit to certain interviews*/
     }              y2=anint[m][i]+(mint[m][i]/12.); /* Fractional date in year */
     fprintf(ficres,"#%s\n",version);              if ((y2>=dateprev1) && (y2<=dateprev2)) { /* Here is the main selection (fractional years) */
                    if(agev[m][i]==0) agev[m][i]=iagemax+1;
     if((fic=fopen(datafile,"r"))==NULL)    {                if(agev[m][i]==1) agev[m][i]=iagemax+2;
       printf("Problem with datafile: %s\n", datafile);goto end;                if((int)agev[m][i] <iagemin || (int)agev[m][i] >iagemax+3) printf("Error on individual =%d agev[m][i]=%f m=%d\n",i, agev[m][i],m); 
     }                if (s[m][i]>0 && s[m][i]<=nlstate) { 
                   /*if(i>4620) printf(" i=%d m=%d s[m][i]=%d (int)agev[m][i]=%d weight[i]=%f prop=%f\n",i,m,s[m][i],(int)agev[m][m],weight[i],prop[s[m][i]][(int)agev[m][i]]);*/
     n= lastobs;                  prop[s[m][i]][(int)agev[m][i]] += weight[i];
     severity = vector(1,maxwav);                  prop[s[m][i]][iagemax+3] += weight[i]; 
     outcome=imatrix(1,maxwav+1,1,n);                } 
     num=ivector(1,n);              }
     moisnais=vector(1,n);            } /* end selection of waves */
     annais=vector(1,n);          }
     moisdc=vector(1,n);        }
     andc=vector(1,n);        for(i=iagemin; i <= iagemax+3; i++){  
     agedc=vector(1,n);          
     cod=ivector(1,n);          for(jk=1,posprop=0; jk <=nlstate ; jk++) { 
     weight=vector(1,n);            posprop += prop[jk][i]; 
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */          } 
     mint=matrix(1,maxwav,1,n);  
     anint=matrix(1,maxwav,1,n);          for(jk=1; jk <=nlstate ; jk++){     
     s=imatrix(1,maxwav+1,1,n);            if( i <=  iagemax){ 
     adl=imatrix(1,maxwav+1,1,n);                  if(posprop>=1.e-5){ 
     tab=ivector(1,NCOVMAX);                probs[i][jk][j1]= prop[jk][i]/posprop;
     ncodemax=ivector(1,8);              } 
             } 
     i=1;          }/* end jk */ 
     while (fgets(line, MAXLINE, fic) != NULL)    {        }/* end i */ 
       if ((i >= firstobs) && (i <=lastobs)) {      } /* end i1 */
            } /* end k1 */
         for (j=maxwav;j>=1;j--){    
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb);    /*  free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);*/
           strcpy(line,stra);    /*free_vector(pp,1,nlstate);*/
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);    free_matrix(prop,1,nlstate, iagemin,iagemax+3);
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);  }  /* End of prevalence */
         }  
          /************* Waves Concatenation ***************/
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);  
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);  void  concatwav(int wav[], int **dh, int **bh,  int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)
   {
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);    /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);       Death is a valid wave (if date is known).
        mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);       dh[m][i] or dh[mw[mi][i]][i] is the delay between two effective waves m=mw[mi][i]
         for (j=ncov;j>=1;j--){       and mw[mi+1][i]. dh depends on stepm.
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);       */
         }  
         num[i]=atol(stra);    int i, mi, m;
            /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;
         /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){       double sum=0., jmean=0.;*/
           printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/    int first;
     int j, k=0,jk, ju, jl;
         i=i+1;    double sum=0.;
       }    first=0;
     }    jmin=1e+5;
     /* printf("ii=%d", ij);    jmax=-1;
        scanf("%d",i);*/    jmean=0.;
   imx=i-1; /* Number of individuals */    for(i=1; i<=imx; i++){
       mi=0;
   /* for (i=1; i<=imx; i++){      m=firstpass;
     if ((s[1][i]==3) && (s[2][i]==2)) s[2][i]=3;      while(s[m][i] <= nlstate){
     if ((s[2][i]==3) && (s[3][i]==2)) s[3][i]=3;        if(s[m][i]>=1 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5)
     if ((s[3][i]==3) && (s[4][i]==2)) s[4][i]=3;          mw[++mi][i]=m;
     }        if(m >=lastpass)
     for (i=1; i<=imx; i++) printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));*/          break;
         else
   /* Calculation of the number of parameter from char model*/          m++;
   Tvar=ivector(1,15);      }/* end while */
   Tprod=ivector(1,15);      if (s[m][i] > nlstate){
   Tvaraff=ivector(1,15);        mi++;     /* Death is another wave */
   Tvard=imatrix(1,15,1,2);        /* if(mi==0)  never been interviewed correctly before death */
   Tage=ivector(1,15);                 /* Only death is a correct wave */
            mw[mi][i]=m;
   if (strlen(model) >1){      }
     j=0, j1=0, k1=1, k2=1;  
     j=nbocc(model,'+');      wav[i]=mi;
     j1=nbocc(model,'*');      if(mi==0){
     cptcovn=j+1;        nbwarn++;
     cptcovprod=j1;        if(first==0){
              printf("Warning! None valid information for:%ld line=%d (skipped) and may be others, see log file\n",num[i],i);
              first=1;
     strcpy(modelsav,model);        }
     if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){        if(first==1){
       printf("Error. Non available option model=%s ",model);          fprintf(ficlog,"Warning! None valid information for:%ld line=%d (skipped)\n",num[i],i);
       goto end;        }
     }      } /* end mi==0 */
        } /* End individuals */
     for(i=(j+1); i>=1;i--){  
       cutv(stra,strb,modelsav,'+');    for(i=1; i<=imx; i++){
       if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav);      for(mi=1; mi<wav[i];mi++){
       /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/        if (stepm <=0)
       /*scanf("%d",i);*/          dh[mi][i]=1;
       if (strchr(strb,'*')) {        else{
         cutv(strd,strc,strb,'*');          if (s[mw[mi+1][i]][i] > nlstate) { /* A death */
         if (strcmp(strc,"age")==0) {            if (agedc[i] < 2*AGESUP) {
           cptcovprod--;              j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12); 
           cutv(strb,stre,strd,'V');              if(j==0) j=1;  /* Survives at least one month after exam */
           Tvar[i]=atoi(stre);              else if(j<0){
           cptcovage++;                nberr++;
             Tage[cptcovage]=i;                printf("Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
             /*printf("stre=%s ", stre);*/                j=1; /* Temporary Dangerous patch */
         }                printf("   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
         else if (strcmp(strd,"age")==0) {                fprintf(ficlog,"Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
           cptcovprod--;                fprintf(ficlog,"   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
           cutv(strb,stre,strc,'V');              }
           Tvar[i]=atoi(stre);              k=k+1;
           cptcovage++;              if (j >= jmax) jmax=j;
           Tage[cptcovage]=i;              if (j <= jmin) jmin=j;
         }              sum=sum+j;
         else {              /*if (j<0) printf("j=%d num=%d \n",j,i);*/
           cutv(strb,stre,strc,'V');              /*    printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
           Tvar[i]=ncov+k1;            }
           cutv(strb,strc,strd,'V');          }
           Tprod[k1]=i;          else{
           Tvard[k1][1]=atoi(strc);            j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));
           Tvard[k1][2]=atoi(stre);  /*        if (j<0) printf("%d %lf %lf %d %d %d\n", i,agev[mw[mi+1][i]][i], agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]); */
           Tvar[cptcovn+k2]=Tvard[k1][1];  
           Tvar[cptcovn+k2+1]=Tvard[k1][2];            k=k+1;
           for (k=1; k<=lastobs;k++)            if (j >= jmax) jmax=j;
             covar[ncov+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];            else if (j <= jmin)jmin=j;
           k1++;            /*        if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */
           k2=k2+2;            /*printf("%d %lf %d %d %d\n", i,agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);*/
         }            if(j<0){
       }              nberr++;
       else {              printf("Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
         /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/              fprintf(ficlog,"Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
        /*  scanf("%d",i);*/            }
       cutv(strd,strc,strb,'V');            sum=sum+j;
       Tvar[i]=atoi(strc);          }
       }          jk= j/stepm;
       strcpy(modelsav,stra);            jl= j -jk*stepm;
       /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);          ju= j -(jk+1)*stepm;
         scanf("%d",i);*/          if(mle <=1){ /* only if we use a the linear-interpoloation pseudo-likelihood */
     }            if(jl==0){
 }              dh[mi][i]=jk;
                bh[mi][i]=0;
   /*printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);            }else{ /* We want a negative bias in order to only have interpolation ie
   printf("cptcovprod=%d ", cptcovprod);                    * at the price of an extra matrix product in likelihood */
   scanf("%d ",i);*/              dh[mi][i]=jk+1;
     fclose(fic);              bh[mi][i]=ju;
             }
     /*  if(mle==1){*/          }else{
     if (weightopt != 1) { /* Maximisation without weights*/            if(jl <= -ju){
       for(i=1;i<=n;i++) weight[i]=1.0;              dh[mi][i]=jk;
     }              bh[mi][i]=jl;       /* bias is positive if real duration
     /*-calculation of age at interview from date of interview and age at death -*/                                   * is higher than the multiple of stepm and negative otherwise.
     agev=matrix(1,maxwav,1,imx);                                   */
             }
    for (i=1; i<=imx; i++)            else{
      for(m=2; (m<= maxwav); m++)              dh[mi][i]=jk+1;
        if ((mint[m][i]== 99) && (s[m][i] <= nlstate)){              bh[mi][i]=ju;
          anint[m][i]=9999;            }
          s[m][i]=-1;            if(dh[mi][i]==0){
        }              dh[mi][i]=1; /* At least one step */
                  bh[mi][i]=ju; /* At least one step */
     for (i=1; i<=imx; i++)  {              /*  printf(" bh=%d ju=%d jl=%d dh=%d jk=%d stepm=%d %d\n",bh[mi][i],ju,jl,dh[mi][i],jk,stepm,i);*/
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);            }
       for(m=1; (m<= maxwav); m++){          } /* end if mle */
         if(s[m][i] >0){        }
           if (s[m][i] == nlstate+1) {      } /* end wave */
             if(agedc[i]>0)    }
               if(moisdc[i]!=99 && andc[i]!=9999)    jmean=sum/k;
               agev[m][i]=agedc[i];    printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);
             else {    fprintf(ficlog,"Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);
               if (andc[i]!=9999){   }
               printf("Warning negative age at death: %d line:%d\n",num[i],i);  
               agev[m][i]=-1;  /*********** Tricode ****************************/
               }  void tricode(int *Tvar, int **nbcode, int imx)
             }  {
           }    
           else if(s[m][i] !=9){ /* Should no more exist */    int Ndum[20],ij=1, k, j, i, maxncov=19;
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);    int cptcode=0;
             if(mint[m][i]==99 || anint[m][i]==9999)    cptcoveff=0; 
               agev[m][i]=1;   
             else if(agev[m][i] <agemin){    for (k=0; k<maxncov; k++) Ndum[k]=0;
               agemin=agev[m][i];    for (k=1; k<=7; k++) ncodemax[k]=0;
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/  
             }    for (j=1; j<=(cptcovn+2*cptcovprod); j++) {
             else if(agev[m][i] >agemax){      for (i=1; i<=imx; i++) { /*reads the data file to get the maximum 
               agemax=agev[m][i];                                 modality*/ 
              /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/        ij=(int)(covar[Tvar[j]][i]); /* ij is the modality of this individual*/
             }        Ndum[ij]++; /*store the modality */
             /*agev[m][i]=anint[m][i]-annais[i];*/        /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/
             /*   agev[m][i] = age[i]+2*m;*/        if (ij > cptcode) cptcode=ij; /* getting the maximum of covariable 
           }                                         Tvar[j]. If V=sex and male is 0 and 
           else { /* =9 */                                         female is 1, then  cptcode=1.*/
             agev[m][i]=1;      }
             s[m][i]=-1;  
           }      for (i=0; i<=cptcode; i++) {
         }        if(Ndum[i]!=0) ncodemax[j]++; /* Nomber of modalities of the j th covariates. In fact ncodemax[j]=2 (dichotom. variables) but it can be more */
         else /*= 0 Unknown */      }
           agev[m][i]=1;  
       }      ij=1; 
          for (i=1; i<=ncodemax[j]; i++) {
     }        for (k=0; k<= maxncov; k++) {
     for (i=1; i<=imx; i++)  {          if (Ndum[k] != 0) {
       for(m=1; (m<= maxwav); m++){            nbcode[Tvar[j]][ij]=k; 
         if (s[m][i] > (nlstate+ndeath)) {            /* store the modality in an array. k is a modality. If we have model=V1+V1*sex then: nbcode[1][1]=0 ; nbcode[1][2]=1; nbcode[2][1]=0 ; nbcode[2][2]=1; */
           printf("Error: Wrong value in nlstate or ndeath\n");              
           goto end;            ij++;
         }          }
       }          if (ij > ncodemax[j]) break; 
     }        }  
       } 
 printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);    }  
   
     free_vector(severity,1,maxwav);   for (k=0; k< maxncov; k++) Ndum[k]=0;
     free_imatrix(outcome,1,maxwav+1,1,n);  
     free_vector(moisnais,1,n);   for (i=1; i<=ncovmodel-2; i++) { 
     free_vector(annais,1,n);     /* Listing of all covariables in statement model to see if some covariates appear twice. For example, V1 appears twice in V1+V1*V2.*/
     /* free_matrix(mint,1,maxwav,1,n);     ij=Tvar[i];
        free_matrix(anint,1,maxwav,1,n);*/     Ndum[ij]++;
     free_vector(moisdc,1,n);   }
     free_vector(andc,1,n);  
    ij=1;
       for (i=1; i<= maxncov; i++) {
     wav=ivector(1,imx);     if((Ndum[i]!=0) && (i<=ncovcol)){
     dh=imatrix(1,lastpass-firstpass+1,1,imx);       Tvaraff[ij]=i; /*For printing */
     mw=imatrix(1,lastpass-firstpass+1,1,imx);       ij++;
         }
     /* Concatenates waves */   }
       concatwav(wav, dh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);   
    cptcoveff=ij-1; /*Number of simple covariates*/
   }
       Tcode=ivector(1,100);  
       nbcode=imatrix(0,NCOVMAX,0,NCOVMAX);  /*********** Health Expectancies ****************/
       ncodemax[1]=1;  
       if (cptcovn > 0) tricode(Tvar,nbcode,imx);  void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij, int estepm,double delti[],double **matcov,char strstart[] )
        
    codtab=imatrix(1,100,1,10);  {
    h=0;    /* Health expectancies */
    m=pow(2,cptcoveff);    int i, j, nhstepm, hstepm, h, nstepm, k, cptj;
      double age, agelim, hf;
    for(k=1;k<=cptcoveff; k++){    double ***p3mat,***varhe;
      for(i=1; i <=(m/pow(2,k));i++){    double **dnewm,**doldm;
        for(j=1; j <= ncodemax[k]; j++){    double *xp;
          for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){    double **gp, **gm;
            h++;    double ***gradg, ***trgradg;
            if (h>m) h=1;codtab[h][k]=j;    int theta;
          }  
        }    varhe=ma3x(1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int) fage);
      }    xp=vector(1,npar);
    }    dnewm=matrix(1,nlstate*nlstate,1,npar);
        doldm=matrix(1,nlstate*nlstate,1,nlstate*nlstate);
    /* Calculates basic frequencies. Computes observed prevalence at single age    
        and prints on file fileres'p'. */    fprintf(ficreseij,"# Local time at start: %s", strstart);
     fprintf(ficreseij,"# Health expectancies\n");
     if ((nbocc(strfprev,'/')==1) && (nbocc(strlprev,'/')==1)){    fprintf(ficreseij,"# Age");
      boolprev=0;    for(i=1; i<=nlstate;i++)
      cutv(stra,strb,strfprev,'/');      for(j=1; j<=nlstate;j++)
      dateprev1=(double)(atoi(strb)+atoi(stra)/12.);        fprintf(ficreseij," %1d-%1d (SE)",i,j);
      cutv(stra,strb,strlprev,'/');    fprintf(ficreseij,"\n");
      dateprev2=(double)(atoi(strb)+atoi(stra)/12.);  
    }    if(estepm < stepm){
          printf ("Problem %d lower than %d\n",estepm, stepm);
    else if ((nbocc(strfprev,'/')==0) &&(nbocc(strlprev,'/')==0)){    }
      boolprev=1;    else  hstepm=estepm;   
      fprev=atoi(strfprev); lprev=atoi(strlprev);    /* We compute the life expectancy from trapezoids spaced every estepm months
    }     * This is mainly to measure the difference between two models: for example
     else {     * if stepm=24 months pijx are given only every 2 years and by summing them
       printf("Error in statement lprevalence or fprevalence\n");     * we are calculating an estimate of the Life Expectancy assuming a linear 
       goto end;     * progression in between and thus overestimating or underestimating according
     }     * to the curvature of the survival function. If, for the same date, we 
         * estimate the model with stepm=1 month, we can keep estepm to 24 months
   freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax, fprev, lprev,mint,anint,boolprev,dateprev1,dateprev2);     * to compare the new estimate of Life expectancy with the same linear 
       * hypothesis. A more precise result, taking into account a more precise
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */     * curvature will be obtained if estepm is as small as stepm. */
     oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */  
     newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    /* For example we decided to compute the life expectancy with the smallest unit */
     savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
     oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */       nhstepm is the number of hstepm from age to agelim 
             nstepm is the number of stepm from age to agelin. 
     /* For Powell, parameters are in a vector p[] starting at p[1]       Look at hpijx to understand the reason of that which relies in memory size
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */       and note for a fixed period like estepm months */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
     if(mle==1){       means that if the survival funtion is printed only each two years of age and if
     mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
     }       results. So we changed our mind and took the option of the best precision.
        */
     /*--------- results files --------------*/    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
     fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate, ndeath, maxwav, mle,weightopt,model);  
    fprintf(ficres,"fprevalence=%s lprevalence=%s pop_based=%d\n",strfprev,strlprev,popbased);    agelim=AGESUP;
    fprintf(ficres,"fprevalence=%s lprevalence=%s nforecast=%d mob_average=%d\n",strfprevfore,strlprevfore,nforecast,mobilav);    for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       /* nhstepm age range expressed in number of stepm */
    jk=1;      nstepm=(int) rint((agelim-age)*YEARM/stepm); 
    fprintf(ficres,"# Parameters\n");      /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
    printf("# Parameters\n");      /* if (stepm >= YEARM) hstepm=1;*/
    for(i=1,jk=1; i <=nlstate; i++){      nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
      for(k=1; k <=(nlstate+ndeath); k++){      p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
        if (k != i)      gradg=ma3x(0,nhstepm,1,npar,1,nlstate*nlstate);
          {      gp=matrix(0,nhstepm,1,nlstate*nlstate);
            printf("%d%d ",i,k);      gm=matrix(0,nhstepm,1,nlstate*nlstate);
            fprintf(ficres,"%1d%1d ",i,k);  
            for(j=1; j <=ncovmodel; j++){      /* Computed by stepm unit matrices, product of hstepm matrices, stored
              printf("%f ",p[jk]);         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
              fprintf(ficres,"%f ",p[jk]);      hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);  
              jk++;   
            }  
            printf("\n");      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
            fprintf(ficres,"\n");  
          }      /* Computing  Variances of health expectancies */
      }  
    }       for(theta=1; theta <=npar; theta++){
  if(mle==1){        for(i=1; i<=npar; i++){ 
     /* Computing hessian and covariance matrix */          xp[i] = x[i] + (i==theta ?delti[theta]:0);
     ftolhess=ftol; /* Usually correct */        }
     hesscov(matcov, p, npar, delti, ftolhess, func);        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
  }    
     fprintf(ficres,"# Scales\n");        cptj=0;
     printf("# Scales\n");        for(j=1; j<= nlstate; j++){
      for(i=1,jk=1; i <=nlstate; i++){          for(i=1; i<=nlstate; i++){
       for(j=1; j <=nlstate+ndeath; j++){            cptj=cptj+1;
         if (j!=i) {            for(h=0, gp[h][cptj]=0.; h<=nhstepm-1; h++){
           fprintf(ficres,"%1d%1d",i,j);              gp[h][cptj] = (p3mat[i][j][h]+p3mat[i][j][h+1])/2.;
           printf("%1d%1d",i,j);            }
           for(k=1; k<=ncovmodel;k++){          }
             printf(" %.5e",delti[jk]);        }
             fprintf(ficres," %.5e",delti[jk]);       
             jk++;       
           }        for(i=1; i<=npar; i++) 
           printf("\n");          xp[i] = x[i] - (i==theta ?delti[theta]:0);
           fprintf(ficres,"\n");        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         }        
       }        cptj=0;
      }        for(j=1; j<= nlstate; j++){
              for(i=1;i<=nlstate;i++){
     k=1;            cptj=cptj+1;
     fprintf(ficres,"# Covariance\n");            for(h=0, gm[h][cptj]=0.; h<=nhstepm-1; h++){
     printf("# Covariance\n");  
     for(i=1;i<=npar;i++){              gm[h][cptj] = (p3mat[i][j][h]+p3mat[i][j][h+1])/2.;
       /*  if (k>nlstate) k=1;            }
       i1=(i-1)/(ncovmodel*nlstate)+1;          }
       fprintf(ficres,"%s%d%d",alph[k],i1,tab[i]);        }
       printf("%s%d%d",alph[k],i1,tab[i]);*/        for(j=1; j<= nlstate*nlstate; j++)
       fprintf(ficres,"%3d",i);          for(h=0; h<=nhstepm-1; h++){
       printf("%3d",i);            gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
       for(j=1; j<=i;j++){          }
         fprintf(ficres," %.5e",matcov[i][j]);       } 
         printf(" %.5e",matcov[i][j]);     
       }  /* End theta */
       fprintf(ficres,"\n");  
       printf("\n");       trgradg =ma3x(0,nhstepm,1,nlstate*nlstate,1,npar);
       k++;  
     }       for(h=0; h<=nhstepm-1; h++)
            for(j=1; j<=nlstate*nlstate;j++)
     while((c=getc(ficpar))=='#' && c!= EOF){          for(theta=1; theta <=npar; theta++)
       ungetc(c,ficpar);            trgradg[h][j][theta]=gradg[h][theta][j];
       fgets(line, MAXLINE, ficpar);       
       puts(line);  
       fputs(line,ficparo);       for(i=1;i<=nlstate*nlstate;i++)
     }        for(j=1;j<=nlstate*nlstate;j++)
     ungetc(c,ficpar);          varhe[i][j][(int)age] =0.;
    
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);       printf("%d|",(int)age);fflush(stdout);
           fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
     if (fage <= 2) {       for(h=0;h<=nhstepm-1;h++){
       bage = agemin;        for(k=0;k<=nhstepm-1;k++){
       fage = agemax;          matprod2(dnewm,trgradg[h],1,nlstate*nlstate,1,npar,1,npar,matcov);
     }          matprod2(doldm,dnewm,1,nlstate*nlstate,1,npar,1,nlstate*nlstate,gradg[k]);
           for(i=1;i<=nlstate*nlstate;i++)
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");            for(j=1;j<=nlstate*nlstate;j++)
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);              varhe[i][j][(int)age] += doldm[i][j]*hf*hf;
         }
          }
 /*------------ gnuplot -------------*/      /* Computing expectancies */
 chdir(pathcd);      for(i=1; i<=nlstate;i++)
   if((ficgp=fopen("graph.plt","w"))==NULL) {        for(j=1; j<=nlstate;j++)
     printf("Problem with file graph.gp");goto end;          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
   }            eij[i][j][(int)age] += (p3mat[i][j][h]+p3mat[i][j][h+1])/2.0*hf;
 #ifdef windows            
   fprintf(ficgp,"cd \"%s\" \n",pathc);  /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
 #endif  
 m=pow(2,cptcoveff);          }
    
  /* 1eme*/      fprintf(ficreseij,"%3.0f",age );
   for (cpt=1; cpt<= nlstate ; cpt ++) {      cptj=0;
    for (k1=1; k1<= m ; k1 ++) {      for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
 #ifdef windows          cptj++;
     fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"vpl%s\" every :::%d::%d u 1:2 \"\%%lf",agemin,fage,fileres,k1-1,k1-1);          fprintf(ficreseij," %9.4f (%.4f)", eij[i][j][(int)age], sqrt(varhe[cptj][cptj][(int)age]) );
 #endif        }
 #ifdef unix      fprintf(ficreseij,"\n");
 fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nplot [%.f:%.f] \"vpl%s\" u 1:2 \"\%%lf",agemin,fage,fileres);     
 #endif      free_matrix(gm,0,nhstepm,1,nlstate*nlstate);
       free_matrix(gp,0,nhstepm,1,nlstate*nlstate);
 for (i=1; i<= nlstate ; i ++) {      free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate*nlstate);
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");      free_ma3x(trgradg,0,nhstepm,1,nlstate*nlstate,1,npar);
   else fprintf(ficgp," \%%*lf (\%%*lf)");      free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
 }    }
     fprintf(ficgp,"\" t\"Stationary prevalence\" w l 0,\"vpl%s\" every :::%d::%d u 1:($2+2*$3) \"\%%lf",fileres,k1-1,k1-1);    printf("\n");
     for (i=1; i<= nlstate ; i ++) {    fprintf(ficlog,"\n");
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");  
   else fprintf(ficgp," \%%*lf (\%%*lf)");    free_vector(xp,1,npar);
 }    free_matrix(dnewm,1,nlstate*nlstate,1,npar);
   fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"vpl%s\" every :::%d::%d u 1:($2-2*$3) \"\%%lf",fileres,k1-1,k1-1);    free_matrix(doldm,1,nlstate*nlstate,1,nlstate*nlstate);
      for (i=1; i<= nlstate ; i ++) {    free_ma3x(varhe,1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int)fage);
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");  }
   else fprintf(ficgp," \%%*lf (\%%*lf)");  
 }    /************ Variance ******************/
      fprintf(ficgp,"\" t\"\" w l 1,\"p%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",fileres,k1-1,k1-1,2+4*(cpt-1));  void varevsij(char optionfilefiname[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, int estepm, int cptcov, int cptcod, int popbased, int mobilav, char strstart[])
 #ifdef unix  {
 fprintf(ficgp,"\nset ter gif small size 400,300");    /* Variance of health expectancies */
 #endif    /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/
 fprintf(ficgp,"\nset out \"v%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);    /* double **newm;*/
    }    double **dnewm,**doldm;
   }    double **dnewmp,**doldmp;
   /*2 eme*/    int i, j, nhstepm, hstepm, h, nstepm ;
     int k, cptcode;
   for (k1=1; k1<= m ; k1 ++) {    double *xp;
     fprintf(ficgp,"set ylabel \"Years\" \nset ter gif small size 400,300\nplot [%.f:%.f] ",agemin,fage);    double **gp, **gm;  /* for var eij */
        double ***gradg, ***trgradg; /*for var eij */
     for (i=1; i<= nlstate+1 ; i ++) {    double **gradgp, **trgradgp; /* for var p point j */
       k=2*i;    double *gpp, *gmp; /* for var p point j */
       fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:2 \"\%%lf",fileres,k1-1,k1-1);    double **varppt; /* for var p point j nlstate to nlstate+ndeath */
       for (j=1; j<= nlstate+1 ; j ++) {    double ***p3mat;
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");    double age,agelim, hf;
   else fprintf(ficgp," \%%*lf (\%%*lf)");    double ***mobaverage;
 }      int theta;
       if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");    char digit[4];
       else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);    char digitp[25];
     fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",fileres,k1-1,k1-1);  
       for (j=1; j<= nlstate+1 ; j ++) {    char fileresprobmorprev[FILENAMELENGTH];
         if (j==i) fprintf(ficgp," \%%lf (\%%lf)");  
         else fprintf(ficgp," \%%*lf (\%%*lf)");    if(popbased==1){
 }        if(mobilav!=0)
       fprintf(ficgp,"\" t\"\" w l 0,");        strcpy(digitp,"-populbased-mobilav-");
      fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",fileres,k1-1,k1-1);      else strcpy(digitp,"-populbased-nomobil-");
       for (j=1; j<= nlstate+1 ; j ++) {    }
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");    else 
   else fprintf(ficgp," \%%*lf (\%%*lf)");      strcpy(digitp,"-stablbased-");
 }    
       if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");    if (mobilav!=0) {
       else fprintf(ficgp,"\" t\"\" w l 0,");      mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     }      if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
     fprintf(ficgp,"\nset out \"e%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),k1);        fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
   }        printf(" Error in movingaverage mobilav=%d\n",mobilav);
        }
   /*3eme*/    }
   
   for (k1=1; k1<= m ; k1 ++) {    strcpy(fileresprobmorprev,"prmorprev"); 
     for (cpt=1; cpt<= nlstate ; cpt ++) {    sprintf(digit,"%-d",ij);
       k=2+nlstate*(cpt-1);    /*printf("DIGIT=%s, ij=%d ijr=%-d|\n",digit, ij,ij);*/
       fprintf(ficgp,"set ter gif small size 400,300\nplot [%.f:%.f] \"e%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",agemin,fage,fileres,k1-1,k1-1,k,cpt);    strcat(fileresprobmorprev,digit); /* Tvar to be done */
       for (i=1; i< nlstate ; i ++) {    strcat(fileresprobmorprev,digitp); /* Popbased or not, mobilav or not */
         fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",fileres,k1-1,k1-1,k+i,cpt,i+1);    strcat(fileresprobmorprev,fileres);
       }    if((ficresprobmorprev=fopen(fileresprobmorprev,"w"))==NULL) {
       fprintf(ficgp,"\nset out \"exp%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);      printf("Problem with resultfile: %s\n", fileresprobmorprev);
     }      fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobmorprev);
   }    }
      printf("Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
   /* CV preval stat */   
   for (k1=1; k1<= m ; k1 ++) {    fprintf(ficlog,"Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
     for (cpt=1; cpt<nlstate ; cpt ++) {    fprintf(ficresprobmorprev, "#Local time at start: %s", strstart);
       k=3;    fprintf(ficresprobmorprev,"# probabilities of dying before estepm=%d months for people of exact age and weighted probabilities w1*p1j+w2*p2j+... stand dev in()\n",estepm);
       fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",agemin,agemax,fileres,k1,k+cpt+1,k+1);    fprintf(ficresprobmorprev,"# Age cov=%-d",ij);
       for (i=1; i< nlstate ; i ++)    for(j=nlstate+1; j<=(nlstate+ndeath);j++){
         fprintf(ficgp,"+$%d",k+i+1);      fprintf(ficresprobmorprev," p.%-d SE",j);
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);      for(i=1; i<=nlstate;i++)
              fprintf(ficresprobmorprev," w%1d p%-d%-d",i,i,j);
       l=3+(nlstate+ndeath)*cpt;    }  
       fprintf(ficgp,",\"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",fileres,k1,l+cpt+1,l+1);    fprintf(ficresprobmorprev,"\n");
       for (i=1; i< nlstate ; i ++) {    fprintf(ficgp,"\n# Routine varevsij");
         l=3+(nlstate+ndeath)*cpt;    /* fprintf(fichtm, "#Local time at start: %s", strstart);*/
         fprintf(ficgp,"+$%d",l+i+1);    fprintf(fichtm,"\n<li><h4> Computing probabilities of dying over estepm months as a weighted average (i.e global mortality independent of initial healh state)</h4></li>\n");
       }    fprintf(fichtm,"\n<br>%s  <br>\n",digitp);
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);    /*   } */
       fprintf(ficgp,"set out \"p%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);    varppt = matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     }   fprintf(ficresvij, "#Local time at start: %s", strstart);
   }      fprintf(ficresvij,"# Variance and covariance of health expectancies e.j \n#  (weighted average of eij where weights are the stable prevalence in health states i\n");
     fprintf(ficresvij,"# Age");
   /* proba elementaires */    for(i=1; i<=nlstate;i++)
    for(i=1,jk=1; i <=nlstate; i++){      for(j=1; j<=nlstate;j++)
     for(k=1; k <=(nlstate+ndeath); k++){        fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);
       if (k != i) {    fprintf(ficresvij,"\n");
         for(j=1; j <=ncovmodel; j++){  
           /*fprintf(ficgp,"%s%1d%1d=%f ",alph[j],i,k,p[jk]);*/    xp=vector(1,npar);
           /*fprintf(ficgp,"%s",alph[1]);*/    dnewm=matrix(1,nlstate,1,npar);
           fprintf(ficgp,"p%d=%f ",jk,p[jk]);    doldm=matrix(1,nlstate,1,nlstate);
           jk++;    dnewmp= matrix(nlstate+1,nlstate+ndeath,1,npar);
           fprintf(ficgp,"\n");    doldmp= matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
         }  
       }    gradgp=matrix(1,npar,nlstate+1,nlstate+ndeath);
     }    gpp=vector(nlstate+1,nlstate+ndeath);
     }    gmp=vector(nlstate+1,nlstate+ndeath);
     trgradgp =matrix(nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
   for(jk=1; jk <=m; jk++) {    
   fprintf(ficgp,"\nset ter gif small size 400,300\nset log y\nplot  [%.f:%.f] ",agemin,agemax);    if(estepm < stepm){
    i=1;      printf ("Problem %d lower than %d\n",estepm, stepm);
    for(k2=1; k2<=nlstate; k2++) {    }
      k3=i;    else  hstepm=estepm;   
      for(k=1; k<=(nlstate+ndeath); k++) {    /* For example we decided to compute the life expectancy with the smallest unit */
        if (k != k2){    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
         fprintf(ficgp," exp(p%d+p%d*x",i,i+1);       nhstepm is the number of hstepm from age to agelim 
 ij=1;       nstepm is the number of stepm from age to agelin. 
         for(j=3; j <=ncovmodel; j++) {       Look at hpijx to understand the reason of that which relies in memory size
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {       and note for a fixed period like k years */
             fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
             ij++;       survival function given by stepm (the optimization length). Unfortunately it
           }       means that if the survival funtion is printed every two years of age and if
           else       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
           fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);       results. So we changed our mind and took the option of the best precision.
         }    */
           fprintf(ficgp,")/(1");    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
            agelim = AGESUP;
         for(k1=1; k1 <=nlstate; k1++){      for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
           fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);      nstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
 ij=1;      nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
           for(j=3; j <=ncovmodel; j++){      p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {      gradg=ma3x(0,nhstepm,1,npar,1,nlstate);
             fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);      gp=matrix(0,nhstepm,1,nlstate);
             ij++;      gm=matrix(0,nhstepm,1,nlstate);
           }  
           else  
             fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);      for(theta=1; theta <=npar; theta++){
           }        for(i=1; i<=npar; i++){ /* Computes gradient x + delta*/
           fprintf(ficgp,")");          xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }        }
         fprintf(ficgp,") t \"p%d%d\" ", k2,k);        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");        prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         i=i+ncovmodel;  
        }        if (popbased==1) {
      }          if(mobilav ==0){
    }            for(i=1; i<=nlstate;i++)
    fprintf(ficgp,"\nset out \"pe%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),jk);              prlim[i][i]=probs[(int)age][i][ij];
   }          }else{ /* mobilav */ 
                for(i=1; i<=nlstate;i++)
   fclose(ficgp);              prlim[i][i]=mobaverage[(int)age][i][ij];
              }
 chdir(path);        }
        
     free_ivector(wav,1,imx);        for(j=1; j<= nlstate; j++){
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);          for(h=0; h<=nhstepm; h++){
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);              for(i=1, gp[h][j]=0.;i<=nlstate;i++)
     free_ivector(num,1,n);              gp[h][j] += prlim[i][i]*p3mat[i][j][h];
     free_vector(agedc,1,n);          }
     /*free_matrix(covar,1,NCOVMAX,1,n);*/        }
     fclose(ficparo);        /* This for computing probability of death (h=1 means
     fclose(ficres);           computed over hstepm matrices product = hstepm*stepm months) 
     /*  }*/           as a weighted average of prlim.
            */
    /*________fin mle=1_________*/        for(j=nlstate+1;j<=nlstate+ndeath;j++){
              for(i=1,gpp[j]=0.; i<= nlstate; i++)
             gpp[j] += prlim[i][i]*p3mat[i][j][1];
          }    
     /* No more information from the sample is required now */        /* end probability of death */
   /* Reads comments: lines beginning with '#' */  
   while((c=getc(ficpar))=='#' && c!= EOF){        for(i=1; i<=npar; i++) /* Computes gradient x - delta */
     ungetc(c,ficpar);          xp[i] = x[i] - (i==theta ?delti[theta]:0);
     fgets(line, MAXLINE, ficpar);        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
     puts(line);        prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
     fputs(line,ficparo);   
   }        if (popbased==1) {
   ungetc(c,ficpar);          if(mobilav ==0){
              for(i=1; i<=nlstate;i++)
   fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);              prlim[i][i]=probs[(int)age][i][ij];
   printf("agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax, bage, fage);          }else{ /* mobilav */ 
   fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);            for(i=1; i<=nlstate;i++)
 /*--------- index.htm --------*/              prlim[i][i]=mobaverage[(int)age][i][ij];
           }
   strcpy(optionfilehtm,optionfile);        }
   strcat(optionfilehtm,".htm");  
   if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {        for(j=1; j<= nlstate; j++){
     printf("Problem with %s \n",optionfilehtm);goto end;          for(h=0; h<=nhstepm; h++){
   }            for(i=1, gm[h][j]=0.;i<=nlstate;i++)
               gm[h][j] += prlim[i][i]*p3mat[i][j][h];
  fprintf(fichtm,"<body><ul> <font size=\"6\">Imach, Version 0.7 </font> <hr size=\"2\" color=\"#EC5E5E\">          }
 Titre=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>        }
 Total number of observations=%d <br>        /* This for computing probability of death (h=1 means
 Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>           computed over hstepm matrices product = hstepm*stepm months) 
 <hr  size=\"2\" color=\"#EC5E5E\">           as a weighted average of prlim.
 <li>Outputs files<br><br>\n        */
         - Observed prevalence in each state: <a href=\"p%s\">p%s</a> <br>\n        for(j=nlstate+1;j<=nlstate+ndeath;j++){
 - Estimated parameters and the covariance matrix: <a href=\"%s\">%s</a> <br>          for(i=1,gmp[j]=0.; i<= nlstate; i++)
         - Stationary prevalence in each state: <a href=\"pl%s\">pl%s</a> <br>           gmp[j] += prlim[i][i]*p3mat[i][j][1];
         - Transition probabilities: <a href=\"pij%s\">pij%s</a><br>        }    
         - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>        /* end probability of death */
         - Life expectancies by age and initial health status: <a href=\"e%s\">e%s</a> <br>  
         - Variances of life expectancies by age and initial health status: <a href=\"v%s\">v%s</a><br>        for(j=1; j<= nlstate; j++) /* vareij */
         - Health expectancies with their variances: <a href=\"t%s\">t%s</a> <br>          for(h=0; h<=nhstepm; h++){
         - Standard deviation of stationary prevalences: <a href=\"vpl%s\">vpl%s</a> <br>            gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
         - Prevalences and population forecasting: <a href=\"f%s\">f%s</a> <br>          }
 <br>",title,datafile,firstpass,lastpass,stepm, weightopt,model,imx,jmin,jmax,jmean,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres);  
         for(j=nlstate+1; j<= nlstate+ndeath; j++){ /* var mu */
  fprintf(fichtm," <li>Graphs</li><p>");          gradgp[theta][j]= (gpp[j]-gmp[j])/2./delti[theta];
         }
  m=cptcoveff;  
  if (cptcovn < 1) {m=1;ncodemax[1]=1;}      } /* End theta */
   
  j1=0;      trgradg =ma3x(0,nhstepm,1,nlstate,1,npar); /* veij */
  for(k1=1; k1<=m;k1++){  
    for(i1=1; i1<=ncodemax[k1];i1++){      for(h=0; h<=nhstepm; h++) /* veij */
        j1++;        for(j=1; j<=nlstate;j++)
        if (cptcovn > 0) {          for(theta=1; theta <=npar; theta++)
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");            trgradg[h][j][theta]=gradg[h][theta][j];
          for (cpt=1; cpt<=cptcoveff;cpt++)  
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[j1][cpt]]);      for(j=nlstate+1; j<=nlstate+ndeath;j++) /* mu */
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");        for(theta=1; theta <=npar; theta++)
        }          trgradgp[j][theta]=gradgp[theta][j];
        fprintf(fichtm,"<br>- Probabilities: pe%s%d.gif<br>    
 <img src=\"pe%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);      
        for(cpt=1; cpt<nlstate;cpt++){      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
          fprintf(fichtm,"<br>- Prevalence of disability : p%s%d%d.gif<br>      for(i=1;i<=nlstate;i++)
 <img src=\"p%s%d%d.gif\">",strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);        for(j=1;j<=nlstate;j++)
        }          vareij[i][j][(int)age] =0.;
     for(cpt=1; cpt<=nlstate;cpt++) {  
        fprintf(fichtm,"<br>- Observed and stationary prevalence (with confident      for(h=0;h<=nhstepm;h++){
 interval) in state (%d): v%s%d%d.gif <br>        for(k=0;k<=nhstepm;k++){
 <img src=\"v%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);            matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);
      }          matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);
      for(cpt=1; cpt<=nlstate;cpt++) {          for(i=1;i<=nlstate;i++)
         fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): exp%s%d%d.gif <br>            for(j=1;j<=nlstate;j++)
 <img src=\"exp%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);              vareij[i][j][(int)age] += doldm[i][j]*hf*hf;
      }        }
      fprintf(fichtm,"\n<br>- Total life expectancy by age and      }
 health expectancies in states (1) and (2): e%s%d.gif<br>    
 <img src=\"e%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);      /* pptj */
 fprintf(fichtm,"\n</body>");      matprod2(dnewmp,trgradgp,nlstate+1,nlstate+ndeath,1,npar,1,npar,matcov);
    }      matprod2(doldmp,dnewmp,nlstate+1,nlstate+ndeath,1,npar,nlstate+1,nlstate+ndeath,gradgp);
  }      for(j=nlstate+1;j<=nlstate+ndeath;j++)
 fclose(fichtm);        for(i=nlstate+1;i<=nlstate+ndeath;i++)
           varppt[j][i]=doldmp[j][i];
   /*--------------- Prevalence limit --------------*/      /* end ppptj */
        /*  x centered again */
   strcpy(filerespl,"pl");      hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm,savm, ij);  
   strcat(filerespl,fileres);      prevalim(prlim,nlstate,x,age,oldm,savm,ftolpl,ij);
   if((ficrespl=fopen(filerespl,"w"))==NULL) {   
     printf("Problem with Prev limit resultfile: %s\n", filerespl);goto end;      if (popbased==1) {
   }        if(mobilav ==0){
   printf("Computing prevalence limit: result on file '%s' \n", filerespl);          for(i=1; i<=nlstate;i++)
   fprintf(ficrespl,"#Prevalence limit\n");            prlim[i][i]=probs[(int)age][i][ij];
   fprintf(ficrespl,"#Age ");        }else{ /* mobilav */ 
   for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);          for(i=1; i<=nlstate;i++)
   fprintf(ficrespl,"\n");            prlim[i][i]=mobaverage[(int)age][i][ij];
          }
   prlim=matrix(1,nlstate,1,nlstate);      }
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */               
   oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */      /* This for computing probability of death (h=1 means
   newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */         computed over hstepm (estepm) matrices product = hstepm*stepm months) 
   savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */         as a weighted average of prlim.
   oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */      */
   k=0;      for(j=nlstate+1;j<=nlstate+ndeath;j++){
   agebase=agemin;        for(i=1,gmp[j]=0.;i<= nlstate; i++) 
   agelim=agemax;          gmp[j] += prlim[i][i]*p3mat[i][j][1]; 
   ftolpl=1.e-10;      }    
   i1=cptcoveff;      /* end probability of death */
   if (cptcovn < 1){i1=1;}  
       fprintf(ficresprobmorprev,"%3d %d ",(int) age, ij);
   for(cptcov=1;cptcov<=i1;cptcov++){      for(j=nlstate+1; j<=(nlstate+ndeath);j++){
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){        fprintf(ficresprobmorprev," %11.3e %11.3e",gmp[j], sqrt(varppt[j][j]));
         k=k+1;        for(i=1; i<=nlstate;i++){
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/          fprintf(ficresprobmorprev," %11.3e %11.3e ",prlim[i][i],p3mat[i][j][1]);
         fprintf(ficrespl,"\n#******");        }
         for(j=1;j<=cptcoveff;j++)      } 
           fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);      fprintf(ficresprobmorprev,"\n");
         fprintf(ficrespl,"******\n");  
              fprintf(ficresvij,"%.0f ",age );
         for (age=agebase; age<=agelim; age++){      for(i=1; i<=nlstate;i++)
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);        for(j=1; j<=nlstate;j++){
           fprintf(ficrespl,"%.0f",age );          fprintf(ficresvij," %.4f", vareij[i][j][(int)age]);
           for(i=1; i<=nlstate;i++)        }
           fprintf(ficrespl," %.5f", prlim[i][i]);      fprintf(ficresvij,"\n");
           fprintf(ficrespl,"\n");      free_matrix(gp,0,nhstepm,1,nlstate);
         }      free_matrix(gm,0,nhstepm,1,nlstate);
       }      free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);
     }      free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);
   fclose(ficrespl);      free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     } /* End age */
   /*------------- h Pij x at various ages ------------*/    free_vector(gpp,nlstate+1,nlstate+ndeath);
      free_vector(gmp,nlstate+1,nlstate+ndeath);
   strcpy(filerespij,"pij");  strcat(filerespij,fileres);    free_matrix(gradgp,1,npar,nlstate+1,nlstate+ndeath);
   if((ficrespij=fopen(filerespij,"w"))==NULL) {    free_matrix(trgradgp,nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     printf("Problem with Pij resultfile: %s\n", filerespij);goto end;    fprintf(ficgp,"\nset noparametric;set nolabel; set ter png small;set size 0.65, 0.65");
   }    /* for(j=nlstate+1; j<= nlstate+ndeath; j++){ *//* Only the first actually */
   printf("Computing pij: result on file '%s' \n", filerespij);    fprintf(ficgp,"\n set log y; set nolog x;set xlabel \"Age\"; set ylabel \"Force of mortality (year-1)\";");
    /*   fprintf(ficgp,"\n plot \"%s\"  u 1:($3*%6.3f) not w l 1 ",fileresprobmorprev,YEARM/estepm); */
   stepsize=(int) (stepm+YEARM-1)/YEARM;  /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)*%6.3f) t \"95\%% interval\" w l 2 ",fileresprobmorprev,YEARM/estepm); */
   /*if (stepm<=24) stepsize=2;*/  /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)*%6.3f) not w l 2 ",fileresprobmorprev,YEARM/estepm); */
     fprintf(ficgp,"\n plot \"%s\"  u 1:($3) not w l 1 ",subdirf(fileresprobmorprev));
   agelim=AGESUP;    fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)) t \"95\%% interval\" w l 2 ",subdirf(fileresprobmorprev));
   hstepm=stepsize*YEARM; /* Every year of age */    fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)) not w l 2 ",subdirf(fileresprobmorprev));
   hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */    fprintf(fichtm,"\n<br> File (multiple files are possible if covariates are present): <A href=\"%s\">%s</a>\n",subdirf(fileresprobmorprev),subdirf(fileresprobmorprev));
      fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months. <br> <img src=\"%s%s.png\"> <br>\n", estepm,subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
   k=0;    /*  fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months and then divided by estepm and multiplied by %.0f in order to have the probability to die over a year <br> <img src=\"varmuptjgr%s%s.png\"> <br>\n", stepm,YEARM,digitp,digit);
   for(cptcov=1;cptcov<=i1;cptcov++){  */
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){  /*   fprintf(ficgp,"\nset out \"varmuptjgr%s%s%s.png\";replot;",digitp,optionfilefiname,digit); */
       k=k+1;    fprintf(ficgp,"\nset out \"%s%s.png\";replot;\n",subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
         fprintf(ficrespij,"\n#****** ");  
         for(j=1;j<=cptcoveff;j++)    free_vector(xp,1,npar);
           fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);    free_matrix(doldm,1,nlstate,1,nlstate);
         fprintf(ficrespij,"******\n");    free_matrix(dnewm,1,nlstate,1,npar);
            free_matrix(doldmp,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */    free_matrix(dnewmp,nlstate+1,nlstate+ndeath,1,npar);
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */    free_matrix(varppt,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */    if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    fclose(ficresprobmorprev);
           oldm=oldms;savm=savms;    fflush(ficgp);
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);      fflush(fichtm); 
           fprintf(ficrespij,"# Age");  }  /* end varevsij */
           for(i=1; i<=nlstate;i++)  
             for(j=1; j<=nlstate+ndeath;j++)  /************ Variance of prevlim ******************/
               fprintf(ficrespij," %1d-%1d",i,j);  void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, char strstart[])
           fprintf(ficrespij,"\n");  {
           for (h=0; h<=nhstepm; h++){    /* Variance of prevalence limit */
             fprintf(ficrespij,"%d %.0f %.0f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );    /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/
             for(i=1; i<=nlstate;i++)    double **newm;
               for(j=1; j<=nlstate+ndeath;j++)    double **dnewm,**doldm;
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);    int i, j, nhstepm, hstepm;
             fprintf(ficrespij,"\n");    int k, cptcode;
           }    double *xp;
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    double *gp, *gm;
           fprintf(ficrespij,"\n");    double **gradg, **trgradg;
         }    double age,agelim;
     }    int theta;
   }    fprintf(ficresvpl, "#Local time at start: %s", strstart); 
     fprintf(ficresvpl,"# Standard deviation of stable prevalences \n");
   /* varprob(fileres, matcov, p, delti, nlstate, (int) bage, (int) fage,k);*/    fprintf(ficresvpl,"# Age");
     for(i=1; i<=nlstate;i++)
   fclose(ficrespij);        fprintf(ficresvpl," %1d-%1d",i,i);
     fprintf(ficresvpl,"\n");
   /*---------- Forecasting ------------------*/  
     xp=vector(1,npar);
   strcpy(fileresf,"f");    dnewm=matrix(1,nlstate,1,npar);
   strcat(fileresf,fileres);    doldm=matrix(1,nlstate,1,nlstate);
   if((ficresf=fopen(fileresf,"w"))==NULL) {    
     printf("Problem with forecast resultfile: %s\n", fileresf);goto end;    hstepm=1*YEARM; /* Every year of age */
   }    hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ 
   printf("Computing forecasting: result on file '%s' \n", fileresf);    agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
  if ((nbocc(strfprevfore,'/')==1) && (nbocc(strlprevfore,'/')==1)){      nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
      boolprev=0;      if (stepm >= YEARM) hstepm=1;
      cutv(stra,strb,strfprevfore,'/');      nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
      dateprev1=(double)(atoi(strb)+atoi(stra)/12.);      gradg=matrix(1,npar,1,nlstate);
      cutv(stra,strb,strlprevfore,'/');      gp=vector(1,nlstate);
      dateprev2=(double)(atoi(strb)+atoi(stra)/12.);      gm=vector(1,nlstate);
    }  
          for(theta=1; theta <=npar; theta++){
    else if ((nbocc(strfprevfore,'/')==0) &&(nbocc(strlprevfore,'/')==0)){        for(i=1; i<=npar; i++){ /* Computes gradient */
      boolprev=1;          xp[i] = x[i] + (i==theta ?delti[theta]:0);
      fprev=atoi(strfprevfore); lprev=atoi(strlprevfore);        }
    }        prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
     else {        for(i=1;i<=nlstate;i++)
       printf("Error in statement lprevalence or fprevalence\n");          gp[i] = prlim[i][i];
       goto end;      
     }        for(i=1; i<=npar; i++) /* Computes gradient */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
   prevalence(agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax, fprevfore, lprevfore,mint,anint,boolprev,dateprev1,dateprev2);        prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
          for(i=1;i<=nlstate;i++)
   free_matrix(mint,1,maxwav,1,n);          gm[i] = prlim[i][i];
   free_matrix(anint,1,maxwav,1,n);  
   free_matrix(agev,1,maxwav,1,imx);        for(i=1;i<=nlstate;i++)
   /* Mobile average */          gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];
       } /* End theta */
   if (cptcoveff==0) ncodemax[cptcoveff]=1;  
       trgradg =matrix(1,nlstate,1,npar);
   if (mobilav==1) {  
     mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);      for(j=1; j<=nlstate;j++)
     for (agedeb=bage+3; agedeb<=fage-2; agedeb++)        for(theta=1; theta <=npar; theta++)
       for (i=1; i<=nlstate;i++)          trgradg[j][theta]=gradg[theta][j];
         for (cptcod=1;cptcod<=ncodemax[cptcov];cptcod++)  
           mobaverage[(int)agedeb][i][cptcod]=0.;      for(i=1;i<=nlstate;i++)
            varpl[i][(int)age] =0.;
     for (agedeb=bage+4; agedeb<=fage; agedeb++){      matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);
       for (i=1; i<=nlstate;i++){      matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);
         for (cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){      for(i=1;i<=nlstate;i++)
           for (cpt=0;cpt<=4;cpt++){        varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */
             mobaverage[(int)agedeb-2][i][cptcod]=mobaverage[(int)agedeb-2][i][cptcod]+probs[(int)agedeb-cpt][i][cptcod];  
           }      fprintf(ficresvpl,"%.0f ",age );
           mobaverage[(int)agedeb-2][i][cptcod]=mobaverage[(int)agedeb-2][i][cptcod]/5;      for(i=1; i<=nlstate;i++)
         }        fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));
       }      fprintf(ficresvpl,"\n");
     }        free_vector(gp,1,nlstate);
   }      free_vector(gm,1,nlstate);
       free_matrix(gradg,1,npar,1,nlstate);
   stepsize=(int) (stepm+YEARM-1)/YEARM;      free_matrix(trgradg,1,nlstate,1,npar);
   if (stepm<=12) stepsize=1;    } /* End age */
   
   agelim=AGESUP;    free_vector(xp,1,npar);
   hstepm=stepsize*YEARM; /* Every year of age */    free_matrix(doldm,1,nlstate,1,npar);
   hstepm=hstepm/stepm; /* Typically 2 years, = 2 years/6 months = 4 */    free_matrix(dnewm,1,nlstate,1,nlstate);
    
   if (popforecast==1) {  }
     if((ficpop=fopen(popfile,"r"))==NULL)    {  
       printf("Problem with population file : %s\n",popfile);goto end;  /************ Variance of one-step probabilities  ******************/
     }  void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[])
     popage=ivector(0,AGESUP);  {
     popeffectif=vector(0,AGESUP);    int i, j=0,  i1, k1, l1, t, tj;
     popcount=vector(0,AGESUP);    int k2, l2, j1,  z1;
     int k=0,l, cptcode;
     i=1;      int first=1, first1;
     while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF)    double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp;
       {    double **dnewm,**doldm;
         i=i+1;    double *xp;
       }    double *gp, *gm;
     imx=i;    double **gradg, **trgradg;
      double **mu;
   for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];    double age,agelim, cov[NCOVMAX];
   }    double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */
     int theta;
   for(cptcov=1;cptcov<=i1;cptcov++){    char fileresprob[FILENAMELENGTH];
     for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){    char fileresprobcov[FILENAMELENGTH];
       k=k+1;    char fileresprobcor[FILENAMELENGTH];
       fprintf(ficresf,"\n#****** ");  
       for(j=1;j<=cptcoveff;j++) {    double ***varpij;
         fprintf(ficresf,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);  
       }    strcpy(fileresprob,"prob"); 
       fprintf(ficresf,"******\n");    strcat(fileresprob,fileres);
       fprintf(ficresf,"# StartingAge FinalAge Horizon(in years)");    if((ficresprob=fopen(fileresprob,"w"))==NULL) {
       for(j=1; j<=nlstate+ndeath;j++) fprintf(ficresf," P.%d",j);      printf("Problem with resultfile: %s\n", fileresprob);
       if (popforecast==1)  fprintf(ficresf," [Population]");      fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob);
     }
       for (agedeb=fage; agedeb>=bage; agedeb--){    strcpy(fileresprobcov,"probcov"); 
         fprintf(ficresf,"\n%.f %.f 0",agedeb, agedeb);    strcat(fileresprobcov,fileres);
        if (mobilav==1) {    if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) {
         for(j=1; j<=nlstate;j++)      printf("Problem with resultfile: %s\n", fileresprobcov);
           fprintf(ficresf," %.3f",mobaverage[(int)agedeb][j][cptcod]);      fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov);
         }    }
         else {    strcpy(fileresprobcor,"probcor"); 
           for(j=1; j<=nlstate;j++)    strcat(fileresprobcor,fileres);
           fprintf(ficresf," %.3f",probs[(int)agedeb][j][cptcod]);    if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) {
         }        printf("Problem with resultfile: %s\n", fileresprobcor);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor);
        for(j=1; j<=ndeath;j++) fprintf(ficresf," 0.00000");    }
        if (popforecast==1) fprintf(ficresf," [%.f] ",popeffectif[(int)agedeb]);    printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
       }    fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
          printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
       for (cpt=1; cpt<=nforecast;cpt++) {    fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
         fprintf(ficresf,"\n");    printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
       for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */    fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
         nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm);    fprintf(ficresprob, "#Local time at start: %s", strstart);
         nhstepm = nhstepm/hstepm;    fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n");
         /*printf("agedeb=%.lf stepm=%d hstepm=%d nhstepm=%d \n",agedeb,stepm,hstepm,nhstepm);*/    fprintf(ficresprob,"# Age");
     fprintf(ficresprobcov, "#Local time at start: %s", strstart);
         p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n");
         oldm=oldms;savm=savms;    fprintf(ficresprobcov,"# Age");
         hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);      fprintf(ficresprobcor, "#Local time at start: %s", strstart);
                    fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n");
         for (h=0; h<=nhstepm; h++){    fprintf(ficresprobcov,"# Age");
          
          if (h*hstepm/YEARM*stepm==cpt)  
             fprintf(ficresf,"\n%.f %.f %.f",agedeb, agedeb+ h*hstepm/YEARM*stepm, h*hstepm/YEARM*stepm);    for(i=1; i<=nlstate;i++)
                for(j=1; j<=(nlstate+ndeath);j++){
                  fprintf(ficresprob," p%1d-%1d (SE)",i,j);
          for(j=1; j<=nlstate+ndeath;j++) {        fprintf(ficresprobcov," p%1d-%1d ",i,j);
            kk1=0.;kk2=0;        fprintf(ficresprobcor," p%1d-%1d ",i,j);
            for(i=1; i<=nlstate;i++) {              }  
              if (mobilav==1)   /* fprintf(ficresprob,"\n");
                 kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb][i][cptcod];    fprintf(ficresprobcov,"\n");
              else kk1=kk1+p3mat[i][j][h]*probs[(int)agedeb][i][cptcod];    fprintf(ficresprobcor,"\n");
              if (popforecast==1) kk2=kk1*popeffectif[(int)agedeb];   */
             }   xp=vector(1,npar);
            if (h*hstepm/YEARM*stepm==cpt) {    dnewm=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
              fprintf(ficresf," %.3f", kk1);    doldm=matrix(1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
                if (popforecast==1) fprintf(ficresf," [%.f]", kk2);    mu=matrix(1,(nlstate)*(nlstate+ndeath), (int) bage, (int)fage);
            }    varpij=ma3x(1,nlstate*(nlstate+ndeath),1,nlstate*(nlstate+ndeath),(int) bage, (int) fage);
           }    first=1;
         }    fprintf(ficgp,"\n# Routine varprob");
         free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    fprintf(fichtm,"\n<li><h4> Computing and drawing one step probabilities with their confidence intervals</h4></li>\n");
            fprintf(fichtm,"\n");
       }  
       }    fprintf(fichtm,"\n<li><h4> <a href=\"%s\">Matrix of variance-covariance of pairs of step probabilities (drawings)</a></h4></li>\n",optionfilehtmcov);
     }    fprintf(fichtmcov,"\n<h4>Matrix of variance-covariance of pairs of step probabilities</h4>\n\
   }    file %s<br>\n",optionfilehtmcov);
   if (mobilav==1) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);    fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (p<inf>ij</inf>, p<inf>kl</inf>) are estimated\
   if (popforecast==1) {  and drawn. It helps understanding how is the covariance between two incidences.\
     free_ivector(popage,0,AGESUP);   They are expressed in year<sup>-1</sup> in order to be less dependent of stepm.<br>\n");
     free_vector(popeffectif,0,AGESUP);    fprintf(fichtmcov,"\n<br> Contour plot corresponding to x'cov<sup>-1</sup>x = 4 (where x is the column vector (pij,pkl)) are drawn. \
     free_vector(popcount,0,AGESUP);  It can be understood this way: if pij and pkl where uncorrelated the (2x2) matrix of covariance \
   }  would have been (1/(var pij), 0 , 0, 1/(var pkl)), and the confidence interval would be 2 \
   free_imatrix(s,1,maxwav+1,1,n);  standard deviations wide on each axis. <br>\
   free_vector(weight,1,n);   Now, if both incidences are correlated (usual case) we diagonalised the inverse of the covariance matrix\
   fclose(ficresf);   and made the appropriate rotation to look at the uncorrelated principal directions.<br>\
   /*---------- Health expectancies and variances ------------*/  To be simple, these graphs help to understand the significativity of each parameter in relation to a second other one.<br> \n");
   
   strcpy(filerest,"t");    cov[1]=1;
   strcat(filerest,fileres);    tj=cptcoveff;
   if((ficrest=fopen(filerest,"w"))==NULL) {    if (cptcovn<1) {tj=1;ncodemax[1]=1;}
     printf("Problem with total LE resultfile: %s\n", filerest);goto end;    j1=0;
   }    for(t=1; t<=tj;t++){
   printf("Computing Total LEs with variances: file '%s' \n", filerest);      for(i1=1; i1<=ncodemax[t];i1++){ 
         j1++;
         if  (cptcovn>0) {
   strcpy(filerese,"e");          fprintf(ficresprob, "\n#********** Variable "); 
   strcat(filerese,fileres);          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprob, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
   if((ficreseij=fopen(filerese,"w"))==NULL) {          fprintf(ficresprob, "**********\n#\n");
     printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);          fprintf(ficresprobcov, "\n#********** Variable "); 
   }          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
   printf("Computing Health Expectancies: result on file '%s' \n", filerese);          fprintf(ficresprobcov, "**********\n#\n");
           
  strcpy(fileresv,"v");          fprintf(ficgp, "\n#********** Variable "); 
   strcat(fileresv,fileres);          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficgp, " V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
   if((ficresvij=fopen(fileresv,"w"))==NULL) {          fprintf(ficgp, "**********\n#\n");
     printf("Problem with variance resultfile: %s\n", fileresv);exit(0);          
   }          
   printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);          fprintf(fichtmcov, "\n<hr  size=\"2\" color=\"#EC5E5E\">********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
   k=0;          fprintf(fichtmcov, "**********\n<hr size=\"2\" color=\"#EC5E5E\">");
   for(cptcov=1;cptcov<=i1;cptcov++){          
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){          fprintf(ficresprobcor, "\n#********** Variable ");    
       k=k+1;          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcor, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
       fprintf(ficrest,"\n#****** ");          fprintf(ficresprobcor, "**********\n#");    
       for(j=1;j<=cptcoveff;j++)        }
         fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);        
       fprintf(ficrest,"******\n");        for (age=bage; age<=fage; age ++){ 
           cov[2]=age;
       fprintf(ficreseij,"\n#****** ");          for (k=1; k<=cptcovn;k++) {
       for(j=1;j<=cptcoveff;j++)            cov[2+k]=nbcode[Tvar[k]][codtab[j1][Tvar[k]]];
         fprintf(ficreseij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);          }
       fprintf(ficreseij,"******\n");          for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
           for (k=1; k<=cptcovprod;k++)
       fprintf(ficresvij,"\n#****** ");            cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
       for(j=1;j<=cptcoveff;j++)          
         fprintf(ficresvij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);          gradg=matrix(1,npar,1,(nlstate)*(nlstate+ndeath));
       fprintf(ficresvij,"******\n");          trgradg=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
           gp=vector(1,(nlstate)*(nlstate+ndeath));
       eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);          gm=vector(1,(nlstate)*(nlstate+ndeath));
       oldm=oldms;savm=savms;      
       evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k);            for(theta=1; theta <=npar; theta++){
       vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);            for(i=1; i<=npar; i++)
       oldm=oldms;savm=savms;              xp[i] = x[i] + (i==theta ?delti[theta]:(double)0);
       varevsij(fileres, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);            
                  pmij(pmmij,cov,ncovmodel,xp,nlstate);
       fprintf(ficrest,"#Total LEs with variances: e.. (std) ");            
       for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);            k=0;
       fprintf(ficrest,"\n");            for(i=1; i<= (nlstate); i++){
                      for(j=1; j<=(nlstate+ndeath);j++){
       hf=1;                k=k+1;
       if (stepm >= YEARM) hf=stepm/YEARM;                gp[k]=pmmij[i][j];
       epj=vector(1,nlstate+1);              }
       for(age=bage; age <=fage ;age++){            }
         prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);            
         if (popbased==1) {            for(i=1; i<=npar; i++)
           for(i=1; i<=nlstate;i++)              xp[i] = x[i] - (i==theta ?delti[theta]:(double)0);
             prlim[i][i]=probs[(int)age][i][k];      
         }            pmij(pmmij,cov,ncovmodel,xp,nlstate);
                    k=0;
         fprintf(ficrest," %.0f",age);            for(i=1; i<=(nlstate); i++){
         for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){              for(j=1; j<=(nlstate+ndeath);j++){
           for(i=1, epj[j]=0.;i <=nlstate;i++) {                k=k+1;
             epj[j] += prlim[i][i]*hf*eij[i][j][(int)age];                gm[k]=pmmij[i][j];
           }              }
           epj[nlstate+1] +=epj[j];            }
         }       
         for(i=1, vepp=0.;i <=nlstate;i++)            for(i=1; i<= (nlstate)*(nlstate+ndeath); i++) 
           for(j=1;j <=nlstate;j++)              gradg[theta][i]=(gp[i]-gm[i])/(double)2./delti[theta];  
             vepp += vareij[i][j][(int)age];          }
         fprintf(ficrest," %.2f (%.2f)", epj[nlstate+1],hf*sqrt(vepp));  
         for(j=1;j <=nlstate;j++){          for(j=1; j<=(nlstate)*(nlstate+ndeath);j++)
           fprintf(ficrest," %.2f (%.2f)", epj[j],hf*sqrt(vareij[j][j][(int)age]));            for(theta=1; theta <=npar; theta++)
         }              trgradg[j][theta]=gradg[theta][j];
         fprintf(ficrest,"\n");          
       }          matprod2(dnewm,trgradg,1,(nlstate)*(nlstate+ndeath),1,npar,1,npar,matcov); 
     }          matprod2(doldm,dnewm,1,(nlstate)*(nlstate+ndeath),1,npar,1,(nlstate)*(nlstate+ndeath),gradg);
   }          free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));
                  free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));
                  free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
           free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
   
  fclose(ficreseij);          pmij(pmmij,cov,ncovmodel,x,nlstate);
  fclose(ficresvij);          
   fclose(ficrest);          k=0;
   fclose(ficpar);          for(i=1; i<=(nlstate); i++){
   free_vector(epj,1,nlstate+1);            for(j=1; j<=(nlstate+ndeath);j++){
   /*  scanf("%d ",i); */              k=k+1;
               mu[k][(int) age]=pmmij[i][j];
   /*------- Variance limit prevalence------*/              }
           }
 strcpy(fileresvpl,"vpl");          for(i=1;i<=(nlstate)*(nlstate+ndeath);i++)
   strcat(fileresvpl,fileres);            for(j=1;j<=(nlstate)*(nlstate+ndeath);j++)
   if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {              varpij[i][j][(int)age] = doldm[i][j];
     printf("Problem with variance prev lim resultfile: %s\n", fileresvpl);  
     exit(0);          /*printf("\n%d ",(int)age);
   }            for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
   printf("Computing Variance-covariance of Prevalence limit: file '%s' \n", fileresvpl);            printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             fprintf(ficlog,"%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
  k=0;            }*/
  for(cptcov=1;cptcov<=i1;cptcov++){  
    for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){          fprintf(ficresprob,"\n%d ",(int)age);
      k=k+1;          fprintf(ficresprobcov,"\n%d ",(int)age);
      fprintf(ficresvpl,"\n#****** ");          fprintf(ficresprobcor,"\n%d ",(int)age);
      for(j=1;j<=cptcoveff;j++)  
        fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);          for (i=1; i<=(nlstate)*(nlstate+ndeath);i++)
      fprintf(ficresvpl,"******\n");            fprintf(ficresprob,"%11.3e (%11.3e) ",mu[i][(int) age],sqrt(varpij[i][i][(int)age]));
                for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
      varpl=matrix(1,nlstate,(int) bage, (int) fage);            fprintf(ficresprobcov,"%11.3e ",mu[i][(int) age]);
      oldm=oldms;savm=savms;            fprintf(ficresprobcor,"%11.3e ",mu[i][(int) age]);
      varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);          }
    }          i=0;
  }          for (k=1; k<=(nlstate);k++){
             for (l=1; l<=(nlstate+ndeath);l++){ 
   fclose(ficresvpl);              i=i++;
               fprintf(ficresprobcov,"\n%d %d-%d",(int)age,k,l);
   /*---------- End : free ----------------*/              fprintf(ficresprobcor,"\n%d %d-%d",(int)age,k,l);
   free_matrix(varpl,1,nlstate,(int) bage, (int)fage);              for (j=1; j<=i;j++){
                  fprintf(ficresprobcov," %11.3e",varpij[i][j][(int)age]);
   free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);                fprintf(ficresprobcor," %11.3e",varpij[i][j][(int) age]/sqrt(varpij[i][i][(int) age])/sqrt(varpij[j][j][(int)age]));
   free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);              }
              }
            }/* end of loop for state */
   free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);        } /* end of loop for age */
   free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);  
   free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);        /* Confidence intervalle of pij  */
   free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);        /*
            fprintf(ficgp,"\nset noparametric;unset label");
   free_matrix(matcov,1,npar,1,npar);          fprintf(ficgp,"\nset log y;unset log x; set xlabel \"Age\";set ylabel \"probability (year-1)\"");
   free_vector(delti,1,npar);          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
            fprintf(fichtm,"\n<br>Probability with  confidence intervals expressed in year<sup>-1</sup> :<a href=\"pijgr%s.png\">pijgr%s.png</A>, ",optionfilefiname,optionfilefiname);
   free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);          fprintf(fichtm,"\n<br><img src=\"pijgr%s.png\"> ",optionfilefiname);
           fprintf(ficgp,"\nset out \"pijgr%s.png\"",optionfilefiname);
   printf("End of Imach\n");          fprintf(ficgp,"\nplot \"%s\" every :::%d::%d u 1:2 \"\%%lf",k1,k2,xfilevarprob);
   /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */        */
    
   /* printf("Total time was %d Sec. %d uSec.\n", end_time.tv_sec -start_time.tv_sec, end_time.tv_usec -start_time.tv_usec);*/        /* Drawing ellipsoids of confidence of two variables p(k1-l1,k2-l2)*/
   /*printf("Total time was %d uSec.\n", total_usecs);*/        first1=1;
   /*------ End -----------*/        for (k2=1; k2<=(nlstate);k2++){
           for (l2=1; l2<=(nlstate+ndeath);l2++){ 
             if(l2==k2) continue;
  end:            j=(k2-1)*(nlstate+ndeath)+l2;
 #ifdef windows            for (k1=1; k1<=(nlstate);k1++){
  chdir(pathcd);              for (l1=1; l1<=(nlstate+ndeath);l1++){ 
 #endif                if(l1==k1) continue;
                  i=(k1-1)*(nlstate+ndeath)+l1;
  system("..\\gp37mgw\\wgnuplot graph.plt");                if(i<=j) continue;
                 for (age=bage; age<=fage; age ++){ 
 #ifdef windows                  if ((int)age %5==0){
   while (z[0] != 'q') {                    v1=varpij[i][i][(int)age]/stepm*YEARM/stepm*YEARM;
     chdir(pathcd);                    v2=varpij[j][j][(int)age]/stepm*YEARM/stepm*YEARM;
     printf("\nType e to edit output files, c to start again, and q for exiting: ");                    cv12=varpij[i][j][(int)age]/stepm*YEARM/stepm*YEARM;
     scanf("%s",z);                    mu1=mu[i][(int) age]/stepm*YEARM ;
     if (z[0] == 'c') system("./imach");                    mu2=mu[j][(int) age]/stepm*YEARM;
     else if (z[0] == 'e') {                    c12=cv12/sqrt(v1*v2);
       chdir(path);                    /* Computing eigen value of matrix of covariance */
       system(optionfilehtm);                    lc1=((v1+v2)+sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
     }                    lc2=((v1+v2)-sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
     else if (z[0] == 'q') exit(0);                    /* Eigen vectors */
   }                    v11=(1./sqrt(1+(v1-lc1)*(v1-lc1)/cv12/cv12));
 #endif                    /*v21=sqrt(1.-v11*v11); *//* error */
 }                    v21=(lc1-v1)/cv12*v11;
                     v12=-v21;
                     v22=v11;
                     tnalp=v21/v11;
                     if(first1==1){
                       first1=0;
                       printf("%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tang %.3f\nOthers in log...\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     }
                     fprintf(ficlog,"%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tan %.3f\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     /*printf(fignu*/
                     /* mu1+ v11*lc1*cost + v12*lc2*sin(t) */
                     /* mu2+ v21*lc1*cost + v22*lc2*sin(t) */
                     if(first==1){
                       first=0;
                       fprintf(ficgp,"\nset parametric;unset label");
                       fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2);
                       fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
                       fprintf(fichtmcov,"\n<br>Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year<sup>-1</sup>\
    :<a href=\"%s%d%1d%1d-%1d%1d.png\">\
   %s%d%1d%1d-%1d%1d.png</A>, ",k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br><img src=\"%s%d%1d%1d-%1d%1d.png\"> ",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br> Correlation at age %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\"",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }else{
                       first=0;
                       fprintf(fichtmcov," %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }/* if first */
                   } /* age mod 5 */
                 } /* end loop age */
                 fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\";replot;",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                 first=1;
               } /*l12 */
             } /* k12 */
           } /*l1 */
         }/* k1 */
       } /* loop covariates */
     }
     free_ma3x(varpij,1,nlstate,1,nlstate+ndeath,(int) bage, (int)fage);
     free_matrix(mu,1,(nlstate+ndeath)*(nlstate+ndeath),(int) bage, (int)fage);
     free_vector(xp,1,npar);
     fclose(ficresprob);
     fclose(ficresprobcov);
     fclose(ficresprobcor);
     fflush(ficgp);
     fflush(fichtmcov);
   }
   
   
   /******************* Printing html file ***********/
   void printinghtml(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,int jmin, int jmax, double jmeanint,char rfileres[],\
                     int popforecast, int estepm ,\
                     double jprev1, double mprev1,double anprev1, \
                     double jprev2, double mprev2,double anprev2){
     int jj1, k1, i1, cpt;
   
      fprintf(fichtm,"<ul><li><a href='#firstorder'>Result files (first order: no variance)</a>\n \
      <li><a href='#secondorder'>Result files (second order (variance)</a>\n \
   </ul>");
      fprintf(fichtm,"<ul><li><h4><a name='firstorder'>Result files (first order: no variance)</a></h4>\n \
    - Observed prevalence in each state (during the period defined between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf): <a href=\"%s\">%s</a> <br>\n ",
              jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,subdirf2(fileres,"p"),subdirf2(fileres,"p"));
      fprintf(fichtm,"\
    - Estimated transition probabilities over %d (stepm) months: <a href=\"%s\">%s</a><br>\n ",
              stepm,subdirf2(fileres,"pij"),subdirf2(fileres,"pij"));
      fprintf(fichtm,"\
    - Stable prevalence in each health state: <a href=\"%s\">%s</a> <br>\n",
              subdirf2(fileres,"pl"),subdirf2(fileres,"pl"));
      fprintf(fichtm,"\
    - Life expectancies by age and initial health status (estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"e"),subdirf2(fileres,"e"));
   
   fprintf(fichtm," \n<ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        /* Pij */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i, %d (stepm) months before: %s%d1.png<br> \
   <img src=\"%s%d1.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1);     
        /* Quasi-incidences */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i %d (stepm) months\
    before but expressed in per year i.e. quasi incidences if stepm is small and probabilities too: %s%d2.png<br> \
   <img src=\"%s%d2.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1); 
          /* Stable prevalence in each health state */
          for(cpt=1; cpt<nlstate;cpt++){
            fprintf(fichtm,"<br>- Stable prevalence in each health state : p%s%d%d.png<br> \
   <img src=\"%s%d%d.png\">",subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1);
          }
        for(cpt=1; cpt<=nlstate;cpt++) {
           fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): %s%d%d.png <br> \
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1);
        }
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
   
   
    fprintf(fichtm,"\
   \n<br><li><h4> <a name='secondorder'>Result files (second order: variances)</a></h4>\n\
    - Parameter file with estimated parameters and covariance matrix: <a href=\"%s\">%s</a> <br>\n", rfileres,rfileres);
   
    fprintf(fichtm," - Variance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"prob"),subdirf2(fileres,"prob"));
    fprintf(fichtm,"\
    - Variance-covariance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcov"),subdirf2(fileres,"probcov"));
   
    fprintf(fichtm,"\
    - Correlation matrix of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcor"),subdirf2(fileres,"probcor"));
    fprintf(fichtm,"\
    - Variances and covariances of life expectancies by age and initial health status (estepm=%d months): <a href=\"%s\">%s</a><br>\n",
            estepm, subdirf2(fileres,"v"),subdirf2(fileres,"v"));
    fprintf(fichtm,"\
    - Health expectancies with their variances (no covariance): <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"t"),subdirf2(fileres,"t"));
    fprintf(fichtm,"\
    - Standard deviation of stable prevalences: <a href=\"%s\">%s</a> <br>\n",\
            subdirf2(fileres,"vpl"),subdirf2(fileres,"vpl"));
   
   /*  if(popforecast==1) fprintf(fichtm,"\n */
   /*  - Prevalences forecasting: <a href=\"f%s\">f%s</a> <br>\n */
   /*  - Population forecasting (if popforecast=1): <a href=\"pop%s\">pop%s</a> <br>\n */
   /*      <br>",fileres,fileres,fileres,fileres); */
   /*  else  */
   /*    fprintf(fichtm,"\n No population forecast: popforecast = %d (instead of 1) or stepm = %d (instead of 1) or model=%s (instead of .)<br><br></li>\n",popforecast, stepm, model); */
    fflush(fichtm);
    fprintf(fichtm," <ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        for(cpt=1; cpt<=nlstate;cpt++) {
          fprintf(fichtm,"<br>- Observed (cross-sectional) and period (incidence based) \
   prevalence (with 95%% confidence interval) in state (%d): %s%d%d.png <br>\
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"v"),cpt,jj1,subdirf2(optionfilefiname,"v"),cpt,jj1);  
        }
        fprintf(fichtm,"\n<br>- Total life expectancy by age and \
   health expectancies in states (1) and (2): %s%d.png<br>\
   <img src=\"%s%d.png\">",subdirf2(optionfilefiname,"e"),jj1,subdirf2(optionfilefiname,"e"),jj1);
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
    fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplot(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   /*   if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */
   /*     printf("Problem with file %s",optionfilegnuplot); */
   /*     fprintf(ficlog,"Problem with file %s",optionfilegnuplot); */
   /*   } */
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
     m=pow(2,cptcoveff);
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
    /* 1eme*/
     for (cpt=1; cpt<= nlstate ; cpt ++) {
      for (k1=1; k1<= m ; k1 ++) {
        fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"v"),cpt,k1);
        fprintf(ficgp,"\n#set out \"v%s%d%d.png\" \n",optionfilefiname,cpt,k1);
        fprintf(ficgp,"set xlabel \"Age\" \n\
   set ylabel \"Probability\" \n\
   set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:2 \"\%%lf",ageminpar,fage,subdirf2(fileres,"vpl"),k1-1,k1-1);
   
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }
        fprintf(ficgp,"\" t\"Stable prevalence\" w l 0,\"%s\" every :::%d::%d u 1:($2+1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1);
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        } 
        fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"%s\" every :::%d::%d u 1:($2-1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1); 
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }  
        fprintf(ficgp,"\" t\"\" w l 1,\"%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",subdirf2(fileres,"p"),k1-1,k1-1,2+4*(cpt-1));
      }
     }
     /*2 eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       fprintf(ficgp,"\nset out \"%s%d.png\" \n",subdirf2(optionfilefiname,"e"),k1);
       fprintf(ficgp,"set ylabel \"Years\" \nset ter png small\nset size 0.65,0.65\nplot [%.f:%.f] ",ageminpar,fage);
       
       for (i=1; i<= nlstate+1 ; i ++) {
         k=2*i;
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:2 \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");
         else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         fprintf(ficgp,"\" t\"\" w l 0,");
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");
         else fprintf(ficgp,"\" t\"\" w l 0,");
       }
     }
     
     /*3eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<= nlstate ; cpt ++) {
         k=2+nlstate*(2*cpt-2);
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"exp"),cpt,k1);
         fprintf(ficgp,"set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",ageminpar,fage,subdirf2(fileres,"e"),k1-1,k1-1,k,cpt);
         /*fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d-2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d+2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           
         */
         for (i=1; i< nlstate ; i ++) {
           fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+2*i,cpt,i+1);
           
         } 
       }
     }
     
     /* CV preval stable (period) */
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<=nlstate ; cpt ++) {
         k=3;
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"p"),cpt,k1);
         fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\
   set ter png small\nset size 0.65,0.65\n\
   unset log y\n\
   plot [%.f:%.f] \"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",ageminpar,agemaxpar,subdirf2(fileres,"pij"),k1,k+cpt+1,k+1);
         
         for (i=1; i< nlstate ; i ++)
           fprintf(ficgp,"+$%d",k+i+1);
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);
         
         l=3+(nlstate+ndeath)*cpt;
         fprintf(ficgp,",\"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",subdirf2(fileres,"pij"),k1,l+cpt+1,l+1);
         for (i=1; i< nlstate ; i ++) {
           l=3+(nlstate+ndeath)*cpt;
           fprintf(ficgp,"+$%d",l+i+1);
         }
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);   
       } 
     }  
     
     /* proba elementaires */
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           for(j=1; j <=ncovmodel; j++){
             fprintf(ficgp,"p%d=%f ",jk,p[jk]);
             jk++; 
             fprintf(ficgp,"\n");
           }
         }
       }
      }
   
      for(ng=1; ng<=2;ng++){ /* Number of graphics: first is probabilities second is incidence per year*/
        for(jk=1; jk <=m; jk++) {
          fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"pe"),jk,ng); 
          if (ng==2)
            fprintf(ficgp,"\nset ylabel \"Quasi-incidence per year\"\n");
          else
            fprintf(ficgp,"\nset title \"Probability\"\n");
          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65\nset log y\nplot  [%.f:%.f] ",ageminpar,agemaxpar);
          i=1;
          for(k2=1; k2<=nlstate; k2++) {
            k3=i;
            for(k=1; k<=(nlstate+ndeath); k++) {
              if (k != k2){
                if(ng==2)
                  fprintf(ficgp," %f*exp(p%d+p%d*x",YEARM/stepm,i,i+1);
                else
                  fprintf(ficgp," exp(p%d+p%d*x",i,i+1);
                ij=1;
                for(j=3; j <=ncovmodel; j++) {
                  if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                    fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                    ij++;
                  }
                  else
                    fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                }
                fprintf(ficgp,")/(1");
                
                for(k1=1; k1 <=nlstate; k1++){   
                  fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);
                  ij=1;
                  for(j=3; j <=ncovmodel; j++){
                    if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                      fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                      ij++;
                    }
                    else
                      fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                  }
                  fprintf(ficgp,")");
                }
                fprintf(ficgp,") t \"p%d%d\" ", k2,k);
                if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");
                i=i+ncovmodel;
              }
            } /* end k */
          } /* end k2 */
        } /* end jk */
      } /* end ng */
      fflush(ficgp); 
   }  /* end gnuplot */
   
   
   /*************** Moving average **************/
   int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav){
   
     int i, cpt, cptcod;
     int modcovmax =1;
     int mobilavrange, mob;
     double age;
   
     modcovmax=2*cptcoveff;/* Max number of modalities. We suppose 
                              a covariate has 2 modalities */
     if (cptcovn<1) modcovmax=1; /* At least 1 pass */
   
     if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){
       if(mobilav==1) mobilavrange=5; /* default */
       else mobilavrange=mobilav;
       for (age=bage; age<=fage; age++)
         for (i=1; i<=nlstate;i++)
           for (cptcod=1;cptcod<=modcovmax;cptcod++)
             mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod];
       /* We keep the original values on the extreme ages bage, fage and for 
          fage+1 and bage-1 we use a 3 terms moving average; for fage+2 bage+2
          we use a 5 terms etc. until the borders are no more concerned. 
       */ 
       for (mob=3;mob <=mobilavrange;mob=mob+2){
         for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){
           for (i=1; i<=nlstate;i++){
             for (cptcod=1;cptcod<=modcovmax;cptcod++){
               mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod];
                 for (cpt=1;cpt<=(mob-1)/2;cpt++){
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod];
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod];
                 }
               mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob;
             }
           }
         }/* end age */
       }/* end mob */
     }else return -1;
     return 0;
   }/* End movingaverage */
   
   
   /************** Forecasting ******************/
   prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){
     /* proj1, year, month, day of starting projection 
        agemin, agemax range of age
        dateprev1 dateprev2 range of dates during which prevalence is computed
        anproj2 year of en of projection (same day and month as proj1).
     */
     int yearp, stepsize, hstepm, nhstepm, j, k, c, cptcod, i, h, i1;
     int *popage;
     double agec; /* generic age */
     double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean;
     double *popeffectif,*popcount;
     double ***p3mat;
     double ***mobaverage;
     char fileresf[FILENAMELENGTH];
   
     agelim=AGESUP;
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
    
     strcpy(fileresf,"f"); 
     strcat(fileresf,fileres);
     if((ficresf=fopen(fileresf,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", fileresf);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", fileresf);
     }
     printf("Computing forecasting: result on file '%s' \n", fileresf);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", fileresf);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
   
     hstepm=hstepm/stepm; 
     yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp  and
                                  fractional in yp1 */
     anprojmean=yp;
     yp2=modf((yp1*12),&yp);
     mprojmean=yp;
     yp1=modf((yp2*30.5),&yp);
     jprojmean=yp;
     if(jprojmean==0) jprojmean=1;
     if(mprojmean==0) jprojmean=1;
   
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
     
     fprintf(ficresf,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); 
     
     fprintf(ficresf,"#****** Routine prevforecast **\n");
   
   /*            if (h==(int)(YEARM*yearp)){ */
     for(cptcov=1, k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficresf,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficresf," V%d=%d, hpijx=probability over h years, hp.jx is weighted by observed prev ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficresf,"******\n");
         fprintf(ficresf,"# Covariate valuofcovar yearproj age");
         for(j=1; j<=nlstate+ndeath;j++){ 
           for(i=1; i<=nlstate;i++)              
             fprintf(ficresf," p%d%d",i,j);
           fprintf(ficresf," p.%d",j);
         }
         for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { 
           fprintf(ficresf,"\n");
           fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp);   
   
           for (agec=fage; agec>=(ageminpar-1); agec--){ 
             nhstepm=(int) rint((agelim-agec)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h*hstepm/YEARM*stepm ==yearp) {
                 fprintf(ficresf,"\n");
                 for(j=1;j<=cptcoveff;j++) 
                   fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
                 fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 ppij=0.;
                 for(i=1; i<=nlstate;i++) {
                   if (mobilav==1) 
                     ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod];
                   else {
                     ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod];
                   }
                   if (h*hstepm/YEARM*stepm== yearp) {
                     fprintf(ficresf," %.3f", p3mat[i][j][h]);
                   }
                 } /* end i */
                 if (h*hstepm/YEARM*stepm==yearp) {
                   fprintf(ficresf," %.3f", ppij);
                 }
               }/* end j */
             } /* end h */
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           } /* end agec */
         } /* end yearp */
       } /* end cptcod */
     } /* end  cptcov */
          
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     fclose(ficresf);
   }
   
   /************** Forecasting *****not tested NB*************/
   populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){
     
     int cpt, stepsize, hstepm, nhstepm, j,k,c, cptcod, i,h;
     int *popage;
     double calagedatem, agelim, kk1, kk2;
     double *popeffectif,*popcount;
     double ***p3mat,***tabpop,***tabpopprev;
     double ***mobaverage;
     char filerespop[FILENAMELENGTH];
   
     tabpop= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     tabpopprev= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     agelim=AGESUP;
     calagedatem=(anpyram+mpyram/12.+jpyram/365.-dateintmean)*YEARM;
     
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     
     
     strcpy(filerespop,"pop"); 
     strcat(filerespop,fileres);
     if((ficrespop=fopen(filerespop,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", filerespop);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", filerespop);
     }
     printf("Computing forecasting: result on file '%s' \n", filerespop);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", filerespop);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     
     agelim=AGESUP;
     
     hstepm=1;
     hstepm=hstepm/stepm; 
     
     if (popforecast==1) {
       if((ficpop=fopen(popfile,"r"))==NULL) {
         printf("Problem with population file : %s\n",popfile);exit(0);
         fprintf(ficlog,"Problem with population file : %s\n",popfile);exit(0);
       } 
       popage=ivector(0,AGESUP);
       popeffectif=vector(0,AGESUP);
       popcount=vector(0,AGESUP);
       
       i=1;   
       while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF) i=i+1;
      
       imx=i;
       for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];
     }
   
     for(cptcov=1,k=0;cptcov<=i2;cptcov++){
      for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficrespop,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespop," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespop,"******\n");
         fprintf(ficrespop,"# Age");
         for(j=1; j<=nlstate+ndeath;j++) fprintf(ficrespop," P.%d",j);
         if (popforecast==1)  fprintf(ficrespop," [Population]");
         
         for (cpt=0; cpt<=0;cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficrespop,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   if (mobilav==1) 
                     kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb+1][i][cptcod];
                   else {
                     kk1=kk1+p3mat[i][j][h]*probs[(int)(agedeb+1)][i][cptcod];
                   }
                 }
                 if (h==(int)(calagedatem+12*cpt)){
                   tabpop[(int)(agedeb)][j][cptcod]=kk1;
                     /*fprintf(ficrespop," %.3f", kk1);
                       if (popforecast==1) fprintf(ficrespop," [%.f]", kk1*popeffectif[(int)agedeb+1]);*/
                 }
               }
               for(i=1; i<=nlstate;i++){
                 kk1=0.;
                   for(j=1; j<=nlstate;j++){
                     kk1= kk1+tabpop[(int)(agedeb)][j][cptcod]; 
                   }
                     tabpopprev[(int)(agedeb)][i][cptcod]=tabpop[(int)(agedeb)][i][cptcod]/kk1*popeffectif[(int)(agedeb+(calagedatem+12*cpt)*hstepm/YEARM*stepm-1)];
               }
   
               if (h==(int)(calagedatem+12*cpt)) for(j=1; j<=nlstate;j++) 
                 fprintf(ficrespop," %15.2f",tabpopprev[(int)(agedeb+1)][j][cptcod]);
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
    
     /******/
   
         for (cpt=1; cpt<=(anpyram1-anpyram);cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficresf,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   kk1=kk1+p3mat[i][j][h]*tabpopprev[(int)agedeb+1][i][cptcod];    
                 }
                 if (h==(int)(calagedatem+12*cpt)) fprintf(ficresf," %15.2f", kk1);        
               }
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
      } 
     }
    
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     if (popforecast==1) {
       free_ivector(popage,0,AGESUP);
       free_vector(popeffectif,0,AGESUP);
       free_vector(popcount,0,AGESUP);
     }
     free_ma3x(tabpop,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(tabpopprev,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficrespop);
   } /* End of popforecast */
   
   int fileappend(FILE *fichier, char *optionfich)
   {
     if((fichier=fopen(optionfich,"a"))==NULL) {
       printf("Problem with file: %s\n", optionfich);
       fprintf(ficlog,"Problem with file: %s\n", optionfich);
       return (0);
     }
     fflush(fichier);
     return (1);
   }
   
   
   /**************** function prwizard **********************/
   void prwizard(int ncovmodel, int nlstate, int ndeath,  char model[], FILE *ficparo)
   {
   
     /* Wizard to print covariance matrix template */
   
     char ca[32], cb[32], cc[32];
     int i,j, k, l, li, lj, lk, ll, jj, npar, itimes;
     int numlinepar;
   
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficparo,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         /*ca[0]= k+'a'-1;ca[1]='\0';*/
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           /*        printf(" %lf",param[i][j][k]); */
           /*        fprintf(ficparo," %lf",param[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficparo,"# Scales (for hessian or gradient estimation)\n");
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/ 
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         fprintf(ficparo,"%1d%1d",i,j);
         printf("%1d%1d",i,j);
         fflush(stdout);
         for(k=1; k<=ncovmodel;k++){
           /*      printf(" %le",delti3[i][j][k]); */
           /*      fprintf(ficparo," %le",delti3[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Covariance matrix\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
     fflush(stdout);
     fprintf(ficparo,"# Covariance matrix\n");
     /* # 121 Var(a12)\n\ */
     /* # 122 Cov(b12,a12) Var(b12)\n\ */
     /* #   ...\n\ */
     /* # 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n" */
     
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               printf("#%1d%1d%d",i,j,k);
               fprintf(ficparo,"#%1d%1d%d",i,j,k);
             }else{
               printf("%1d%1d%d",i,j,k);
               fprintf(ficparo,"%1d%1d%d",i,j,k);
               /*  printf(" %.5le",matcov[i][j]); */
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficparo," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }else{
                       if(itimes==1){
                         printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficparo," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             printf("\n");
             fprintf(ficparo,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
   } /* end of prwizard */
   /******************* Gompertz Likelihood ******************************/
   double gompertz(double x[])
   { 
     double A,B,L=0.0,sump=0.,num=0.;
     int i,n=0; /* n is the size of the sample */
     for (i=0;i<=imx-1 ; i++) {
       sump=sump+weight[i];
       /*    sump=sump+1;*/
       num=num+1;
     }
    
    
     /* for (i=0; i<=imx; i++) 
        if (wav[i]>0) printf("i=%d ageex=%lf agecens=%lf agedc=%lf cens=%d %d\n" ,i,ageexmed[i],agecens[i],agedc[i],cens[i],wav[i]);*/
   
     for (i=1;i<=imx ; i++)
       {
         if (cens[i]==1 & wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agecens[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)));
         
         if (cens[i]==0 & wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agedc[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)))
                +log(x[1]/YEARM)+x[2]*(agedc[i]-agegomp)+log(YEARM);  
         
         if (wav[i]>1 & agecens[i]>15) {
           L=L+A*weight[i];
           /*      printf("\ni=%d A=%f L=%lf x[1]=%lf x[2]=%lf ageex=%lf agecens=%lf cens=%d agedc=%lf weight=%lf\n",i,A,L,x[1],x[2],ageexmed[i]*12,agecens[i]*12,cens[i],agedc[i]*12,weight[i]);*/
         }
       }
   
    /*printf("x1=%2.9f x2=%2.9f x3=%2.9f L=%f\n",x[1],x[2],x[3],L);*/
    
     return -2*L*num/sump;
   }
   
   /******************* Printing html file ***********/
   void printinghtmlmort(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,  double p[],double **matcov,double agemortsup){
     int i,k;
   
     fprintf(fichtm,"<ul><li><h4>Result files </h4>\n Force of mortality. Parameters of the Gompertz fit (with confidence interval in brackets):<br>");
     fprintf(fichtm,"  mu(age) =%lf*exp(%lf*(age-%d)) per year<br><br>",p[1],p[2],agegomp);
     for (i=1;i<=2;i++) 
       fprintf(fichtm," p[%d] = %lf [%f ; %f]<br>\n",i,p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
     fprintf(fichtm,"<br><br><img src=\"graphmort.png\">");
     fprintf(fichtm,"</ul>");
   
   fprintf(fichtm,"<ul><li><h4>Life table</h4>\n <br>");
   
    fprintf(fichtm,"\nAge   l<inf>x</inf>     q<inf>x</inf> d(x,x+1)    L<inf>x</inf>     T<inf>x</inf>     e<infx</inf><br>");
   
    for (k=agegomp;k<(agemortsup-2);k++) 
      fprintf(fichtm,"%d %.0lf %lf %.0lf %.0lf %.0lf %lf<br>\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
    
     fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplotmort(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
   
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
     fprintf(ficgp,"set out \"graphmort.png\"\n "); 
     fprintf(ficgp,"set xlabel \"Age\"\n set ylabel \"Force of mortality (per year)\" \n "); 
     fprintf(ficgp, "set ter png small\n set log y\n"); 
     fprintf(ficgp, "set size 0.65,0.65\n");
     fprintf(ficgp,"plot [%d:100] %lf*exp(%lf*(x-%d))",agegomp,p[1],p[2],agegomp);
   
   } 
   
   
   
   
   /***********************************************/
   /**************** Main Program *****************/
   /***********************************************/
   
   int main(int argc, char *argv[])
   {
     int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav);
     int i,j, k, n=MAXN,iter,m,size=100,cptcode, cptcod;
     int jj, ll, li, lj, lk, imk;
     int numlinepar=0; /* Current linenumber of parameter file */
     int itimes;
     int NDIM=2;
   
     char ca[32], cb[32], cc[32];
     /*  FILE *fichtm; *//* Html File */
     /* FILE *ficgp;*/ /*Gnuplot File */
     struct stat info;
     double agedeb, agefin,hf;
     double ageminpar=1.e20,agemin=1.e20, agemaxpar=-1.e20, agemax=-1.e20;
   
     double fret;
     double **xi,tmp,delta;
   
     double dum; /* Dummy variable */
     double ***p3mat;
     double ***mobaverage;
     int *indx;
     char line[MAXLINE], linepar[MAXLINE];
     char path[MAXLINE],pathc[MAXLINE],pathcd[MAXLINE],pathtot[MAXLINE],model[MAXLINE];
     char pathr[MAXLINE], pathimach[MAXLINE]; 
     int firstobs=1, lastobs=10;
     int sdeb, sfin; /* Status at beginning and end */
     int c,  h , cpt,l;
     int ju,jl, mi;
     int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;
     int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,*tab; 
     int mobilavproj=0 , prevfcast=0 ; /* moving average of prev, If prevfcast=1 prevalence projection */
     int mobilav=0,popforecast=0;
     int hstepm, nhstepm;
     int agemortsup;
     float  sumlpop=0.;
     double jprev1=1, mprev1=1,anprev1=2000,jprev2=1, mprev2=1,anprev2=2000;
     double jpyram=1, mpyram=1,anpyram=2000,jpyram1=1, mpyram1=1,anpyram1=2000;
   
     double bage, fage, age, agelim, agebase;
     double ftolpl=FTOL;
     double **prlim;
     double *severity;
     double ***param; /* Matrix of parameters */
     double  *p;
     double **matcov; /* Matrix of covariance */
     double ***delti3; /* Scale */
     double *delti; /* Scale */
     double ***eij, ***vareij;
     double **varpl; /* Variances of prevalence limits by age */
     double *epj, vepp;
     double kk1, kk2;
     double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000;
     double **ximort;
     char *alph[]={"a","a","b","c","d","e"}, str[4];
     int *dcwave;
   
     char z[1]="c", occ;
   
     char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];
     char strstart[80], *strt, strtend[80];
     char *stratrunc;
     int lstra;
   
     long total_usecs;
    
   /*   setlocale (LC_ALL, ""); */
   /*   bindtextdomain (PACKAGE, LOCALEDIR); */
   /*   textdomain (PACKAGE); */
   /*   setlocale (LC_CTYPE, ""); */
   /*   setlocale (LC_MESSAGES, ""); */
   
     /*   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */
     (void) gettimeofday(&start_time,&tzp);
     curr_time=start_time;
     tm = *localtime(&start_time.tv_sec);
     tmg = *gmtime(&start_time.tv_sec);
     strcpy(strstart,asctime(&tm));
   
   /*  printf("Localtime (at start)=%s",strstart); */
   /*  tp.tv_sec = tp.tv_sec +86400; */
   /*  tm = *localtime(&start_time.tv_sec); */
   /*   tmg.tm_year=tmg.tm_year +dsign*dyear; */
   /*   tmg.tm_mon=tmg.tm_mon +dsign*dmonth; */
   /*   tmg.tm_hour=tmg.tm_hour + 1; */
   /*   tp.tv_sec = mktime(&tmg); */
   /*   strt=asctime(&tmg); */
   /*   printf("Time(after) =%s",strstart);  */
   /*  (void) time (&time_value);
   *  printf("time=%d,t-=%d\n",time_value,time_value-86400);
   *  tm = *localtime(&time_value);
   *  strstart=asctime(&tm);
   *  printf("tim_value=%d,asctime=%s\n",time_value,strstart); 
   */
   
     nberr=0; /* Number of errors and warnings */
     nbwarn=0;
     getcwd(pathcd, size);
   
     printf("\n%s\n%s",version,fullversion);
     if(argc <=1){
       printf("\nEnter the parameter file name: ");
       scanf("%s",pathtot);
     }
     else{
       strcpy(pathtot,argv[1]);
     }
     /*if(getcwd(pathcd, MAXLINE)!= NULL)printf ("Error pathcd\n");*/
     /*cygwin_split_path(pathtot,path,optionfile);
       printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/
     /* cutv(path,optionfile,pathtot,'\\');*/
   
     /* Split argv[0], imach program to get pathimach */
     printf("\nargv[0]=%s argv[1]=%s, \n",argv[0],argv[1]);
     split(argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
     printf("\nargv[0]=%s pathimach=%s, \noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
    /*   strcpy(pathimach,argv[0]); */
     /* Split argv[1]=pathtot, parameter file name to get path, optionfile, extension and name */
     split(pathtot,path,optionfile,optionfilext,optionfilefiname);
     printf("\npathtot=%s,\npath=%s,\noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
     chdir(path);
     strcpy(command,"mkdir ");
     strcat(command,optionfilefiname);
     if((outcmd=system(command)) != 0){
       printf("Problem creating directory or it already exists %s%s, err=%d\n",path,optionfilefiname,outcmd);
       /* fprintf(ficlog,"Problem creating directory %s%s\n",path,optionfilefiname); */
       /* fclose(ficlog); */
   /*     exit(1); */
     }
   /*   if((imk=mkdir(optionfilefiname))<0){ */
   /*     perror("mkdir"); */
   /*   } */
   
     /*-------- arguments in the command line --------*/
   
     /* Log file */
     strcat(filelog, optionfilefiname);
     strcat(filelog,".log");    /* */
     if((ficlog=fopen(filelog,"w"))==NULL)    {
       printf("Problem with logfile %s\n",filelog);
       goto end;
     }
     fprintf(ficlog,"Log filename:%s\n",filelog);
     fprintf(ficlog,"\n%s\n%s",version,fullversion);
     fprintf(ficlog,"\nEnter the parameter file name: \n");
     fprintf(ficlog,"pathimach=%s\npathtot=%s\n\
    path=%s \n\
    optionfile=%s\n\
    optionfilext=%s\n\
    optionfilefiname=%s\n",pathimach,pathtot,path,optionfile,optionfilext,optionfilefiname);
   
     printf("Local time (at start):%s",strstart);
     fprintf(ficlog,"Local time (at start): %s",strstart);
     fflush(ficlog);
   /*   (void) gettimeofday(&curr_time,&tzp); */
   /*   printf("Elapsed time %d\n", asc_diff_time(curr_time.tv_sec-start_time.tv_sec,tmpout)); */
   
     /* */
     strcpy(fileres,"r");
     strcat(fileres, optionfilefiname);
     strcat(fileres,".txt");    /* Other files have txt extension */
   
     /*---------arguments file --------*/
   
     if((ficpar=fopen(optionfile,"r"))==NULL)    {
       printf("Problem with optionfile %s\n",optionfile);
       fprintf(ficlog,"Problem with optionfile %s\n",optionfile);
       fflush(ficlog);
       goto end;
     }
   
   
   
     strcpy(filereso,"o");
     strcat(filereso,fileres);
     if((ficparo=fopen(filereso,"w"))==NULL) { /* opened on subdirectory */
       printf("Problem with Output resultfile: %s\n", filereso);
       fprintf(ficlog,"Problem with Output resultfile: %s\n", filereso);
       fflush(ficlog);
       goto end;
     }
   
     /* Reads comments: lines beginning with '#' */
     numlinepar=0;
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d model=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncovcol, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);
     numlinepar++;
     printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate,ndeath, maxwav, mle, weightopt,model);
     fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fprintf(ficlog,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fflush(ficlog);
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
      
     covar=matrix(0,NCOVMAX,1,n); 
     cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement*/
     if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;
   
     ncovmodel=2+cptcovn; /*Number of variables = cptcovn + intercept + age */
     nvar=ncovmodel-1; /* Suppressing age as a basic covariate */
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/
   
     delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     delti=delti3[1][1];
     /*delti=vector(1,npar); *//* Scale of each paramater (output from hesscov)*/
     if(mle==-1){ /* Print a wizard for help writing covariance matrix */
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       fclose (ficparo);
       fclose (ficlog);
       exit(0);
     }
     else if(mle==-3) {
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       matcov=matrix(1,npar,1,npar);
     }
     else{
       /* Read guess parameters */
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
       
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       for(i=1; i <=nlstate; i++){
         j=0;
         for(jj=1; jj <=nlstate+ndeath; jj++){
           if(jj==i) continue;
           j++;
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1 != i) && (j1 != j)){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           fprintf(ficparo,"%1d%1d",i1,j1);
           if(mle==1)
             printf("%1d%1d",i,j);
           fprintf(ficlog,"%1d%1d",i,j);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar," %lf",&param[i][j][k]);
             if(mle==1){
               printf(" %lf",param[i][j][k]);
               fprintf(ficlog," %lf",param[i][j][k]);
             }
             else
               fprintf(ficlog," %lf",param[i][j][k]);
             fprintf(ficparo," %lf",param[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           if(mle==1)
             printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficparo,"\n");
         }
       }  
       fflush(ficlog);
   
   
       p=param[1][1];
       
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
   
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath-1; j++){
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1-i)*(j1-j)!=0){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           printf("%1d%1d",i,j);
           fprintf(ficparo,"%1d%1d",i1,j1);
           fprintf(ficlog,"%1d%1d",i1,j1);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar,"%le",&delti3[i][j][k]);
             printf(" %le",delti3[i][j][k]);
             fprintf(ficparo," %le",delti3[i][j][k]);
             fprintf(ficlog," %le",delti3[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           printf("\n");
           fprintf(ficparo,"\n");
           fprintf(ficlog,"\n");
         }
       }
       fflush(ficlog);
   
       delti=delti3[1][1];
   
   
       /* free_ma3x(delti3,1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ /* Hasn't to to freed here otherwise delti is no more allocated */
     
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
     
       matcov=matrix(1,npar,1,npar);
       for(i=1; i <=npar; i++){
         fscanf(ficpar,"%s",&str);
         if(mle==1)
           printf("%s",str);
         fprintf(ficlog,"%s",str);
         fprintf(ficparo,"%s",str);
         for(j=1; j <=i; j++){
           fscanf(ficpar," %le",&matcov[i][j]);
           if(mle==1){
             printf(" %.5le",matcov[i][j]);
           }
           fprintf(ficlog," %.5le",matcov[i][j]);
           fprintf(ficparo," %.5le",matcov[i][j]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         if(mle==1)
           printf("\n");
         fprintf(ficlog,"\n");
         fprintf(ficparo,"\n");
       }
       for(i=1; i <=npar; i++)
         for(j=i+1;j<=npar;j++)
           matcov[i][j]=matcov[j][i];
       
       if(mle==1)
         printf("\n");
       fprintf(ficlog,"\n");
       
       fflush(ficlog);
       
       /*-------- Rewriting parameter file ----------*/
       strcpy(rfileres,"r");    /* "Rparameterfile */
       strcat(rfileres,optionfilefiname);    /* Parameter file first name*/
       strcat(rfileres,".");    /* */
       strcat(rfileres,optionfilext);    /* Other files have txt extension */
       if((ficres =fopen(rfileres,"w"))==NULL) {
         printf("Problem writing new parameter file: %s\n", fileres);goto end;
         fprintf(ficlog,"Problem writing new parameter file: %s\n", fileres);goto end;
       }
       fprintf(ficres,"#%s\n",version);
     }    /* End of mle != -3 */
   
     /*-------- data file ----------*/
     if((fic=fopen(datafile,"r"))==NULL)    {
       printf("Problem with datafile: %s\n", datafile);goto end;
       fprintf(ficlog,"Problem with datafile: %s\n", datafile);goto end;
     }
   
     n= lastobs;
     severity = vector(1,maxwav);
     outcome=imatrix(1,maxwav+1,1,n);
     num=lvector(1,n);
     moisnais=vector(1,n);
     annais=vector(1,n);
     moisdc=vector(1,n);
     andc=vector(1,n);
     agedc=vector(1,n);
     cod=ivector(1,n);
     weight=vector(1,n);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */
     mint=matrix(1,maxwav,1,n);
     anint=matrix(1,maxwav,1,n);
     s=imatrix(1,maxwav+1,1,n);
     tab=ivector(1,NCOVMAX);
     ncodemax=ivector(1,8);
   
     i=1;
     while (fgets(line, MAXLINE, fic) != NULL)    {
       if ((i >= firstobs) && (i <=lastobs)) {
         for(j=0; line[j] != '\n';j++){  /* Untabifies line */
           if(line[j] == '\t')
             line[j] = ' ';
         }
         for (j=maxwav;j>=1;j--){
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb); 
           strcpy(line,stra);
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);
         }
           
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);
   
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);
   
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);
         for (j=ncovcol;j>=1;j--){
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);
         } 
         lstra=strlen(stra);
         if(lstra > 9){ /* More than 2**32 or max of what printf can write with %ld */
           stratrunc = &(stra[lstra-9]);
           num[i]=atol(stratrunc);
         }
         else
           num[i]=atol(stra);
           
         /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){
           printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/
   
         i=i+1;
       }
     }
     /* printf("ii=%d", ij);
        scanf("%d",i);*/
     imx=i-1; /* Number of individuals */
   
     /* for (i=1; i<=imx; i++){
       if ((s[1][i]==3) && (s[2][i]==2)) s[2][i]=3;
       if ((s[2][i]==3) && (s[3][i]==2)) s[3][i]=3;
       if ((s[3][i]==3) && (s[4][i]==2)) s[4][i]=3;
       }*/
      /*  for (i=1; i<=imx; i++){
        if (s[4][i]==9)  s[4][i]=-1; 
        printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));}*/
     
     /* for (i=1; i<=imx; i++) */
    
      /*if ((s[3][i]==3) ||  (s[4][i]==3)) weight[i]=0.08;
        else weight[i]=1;*/
   
     /* Calculation of the number of parameters from char model */
     Tvar=ivector(1,15); /* stores the number n of the covariates in Vm+Vn at 1 and m at 2 */
     Tprod=ivector(1,15); 
     Tvaraff=ivector(1,15); 
     Tvard=imatrix(1,15,1,2);
     Tage=ivector(1,15);      
      
     if (strlen(model) >1){ /* If there is at least 1 covariate */
       j=0, j1=0, k1=1, k2=1;
       j=nbocc(model,'+'); /* j=Number of '+' */
       j1=nbocc(model,'*'); /* j1=Number of '*' */
       cptcovn=j+1; 
       cptcovprod=j1; /*Number of products */
       
       strcpy(modelsav,model); 
       if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){
         printf("Error. Non available option model=%s ",model);
         fprintf(ficlog,"Error. Non available option model=%s ",model);
         goto end;
       }
       
       /* This loop fills the array Tvar from the string 'model'.*/
   
       for(i=(j+1); i>=1;i--){
         cutv(stra,strb,modelsav,'+'); /* keeps in strb after the last + */ 
         if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav); /* and analyzes it */
         /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/
         /*scanf("%d",i);*/
         if (strchr(strb,'*')) {  /* Model includes a product */
           cutv(strd,strc,strb,'*'); /* strd*strc  Vm*Vn (if not *age)*/
           if (strcmp(strc,"age")==0) { /* Vn*age */
             cptcovprod--;
             cutv(strb,stre,strd,'V');
             Tvar[i]=atoi(stre); /* computes n in Vn and stores in Tvar*/
             cptcovage++;
               Tage[cptcovage]=i;
               /*printf("stre=%s ", stre);*/
           }
           else if (strcmp(strd,"age")==0) { /* or age*Vn */
             cptcovprod--;
             cutv(strb,stre,strc,'V');
             Tvar[i]=atoi(stre);
             cptcovage++;
             Tage[cptcovage]=i;
           }
           else {  /* Age is not in the model */
             cutv(strb,stre,strc,'V'); /* strc= Vn, stre is n*/
             Tvar[i]=ncovcol+k1;
             cutv(strb,strc,strd,'V'); /* strd was Vm, strc is m */
             Tprod[k1]=i;
             Tvard[k1][1]=atoi(strc); /* m*/
             Tvard[k1][2]=atoi(stre); /* n */
             Tvar[cptcovn+k2]=Tvard[k1][1];
             Tvar[cptcovn+k2+1]=Tvard[k1][2]; 
             for (k=1; k<=lastobs;k++) 
               covar[ncovcol+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];
             k1++;
             k2=k2+2;
           }
         }
         else { /* no more sum */
           /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/
          /*  scanf("%d",i);*/
         cutv(strd,strc,strb,'V');
         Tvar[i]=atoi(strc);
         }
         strcpy(modelsav,stra);  
         /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);
           scanf("%d",i);*/
       } /* end of loop + */
     } /* end model */
     
     /*The number n of Vn is stored in Tvar. cptcovage =number of age covariate. Tage gives the position of age. cptcovprod= number of products.
       If model=V1+V1*age then Tvar[1]=1 Tvar[2]=1 cptcovage=1 Tage[1]=2 cptcovprod=0*/
   
     /* printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);
     printf("cptcovprod=%d ", cptcovprod);
     fprintf(ficlog,"cptcovprod=%d ", cptcovprod);
   
     scanf("%d ",i);
     fclose(fic);*/
   
       /*  if(mle==1){*/
     if (weightopt != 1) { /* Maximisation without weights*/
       for(i=1;i<=n;i++) weight[i]=1.0;
     }
       /*-calculation of age at interview from date of interview and age at death -*/
     agev=matrix(1,maxwav,1,imx);
   
     for (i=1; i<=imx; i++) {
       for(m=2; (m<= maxwav); m++) {
         if (((int)mint[m][i]== 99) && (s[m][i] <= nlstate)){
           anint[m][i]=9999;
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]==9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           fprintf(ficlog,"Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]!=9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Month of death of individual %ld on line %d was unknown %2d, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,(int)moisdc[i]); 
           fprintf(ficlog,"Error! Month of death of individual %ld on line %d was unknown %f, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,moisdc[i]); 
           s[m][i]=-1; /* We prefer to skip it (and to skip it in version 0.8a1 too */
         }
       }
     }
   
     for (i=1; i<=imx; i++)  {
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);
       for(m=firstpass; (m<= lastpass); m++){
         if(s[m][i] >0 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5){
           if (s[m][i] >= nlstate+1) {
             if(agedc[i]>0)
               if((int)moisdc[i]!=99 && (int)andc[i]!=9999)
                 agev[m][i]=agedc[i];
             /*if(moisdc[i]==99 && andc[i]==9999) s[m][i]=-1;*/
               else {
                 if ((int)andc[i]!=9999){
                   nbwarn++;
                   printf("Warning negative age at death: %ld line:%d\n",num[i],i);
                   fprintf(ficlog,"Warning negative age at death: %ld line:%d\n",num[i],i);
                   agev[m][i]=-1;
                 }
               }
           }
           else if(s[m][i] !=9){ /* Standard case, age in fractional
                                    years but with the precision of a
                                    month */
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);
             if((int)mint[m][i]==99 || (int)anint[m][i]==9999)
               agev[m][i]=1;
             else if(agev[m][i] <agemin){ 
               agemin=agev[m][i];
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/
             }
             else if(agev[m][i] >agemax){
               agemax=agev[m][i];
               /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/
             }
             /*agev[m][i]=anint[m][i]-annais[i];*/
             /*     agev[m][i] = age[i]+2*m;*/
           }
           else { /* =9 */
             agev[m][i]=1;
             s[m][i]=-1;
           }
         }
         else /*= 0 Unknown */
           agev[m][i]=1;
       }
       
     }
     for (i=1; i<=imx; i++)  {
       for(m=firstpass; (m<=lastpass); m++){
         if (s[m][i] > (nlstate+ndeath)) {
           nberr++;
           printf("Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           fprintf(ficlog,"Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           goto end;
         }
       }
     }
   
     /*for (i=1; i<=imx; i++){
     for (m=firstpass; (m<lastpass); m++){
        printf("%ld %d %.lf %d %d\n", num[i],(covar[1][i]),agev[m][i],s[m][i],s[m+1][i]);
   }
   
   }*/
   
   
     printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);
     fprintf(ficlog,"Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax); 
   
     agegomp=(int)agemin;
     free_vector(severity,1,maxwav);
     free_imatrix(outcome,1,maxwav+1,1,n);
     free_vector(moisnais,1,n);
     free_vector(annais,1,n);
     /* free_matrix(mint,1,maxwav,1,n);
        free_matrix(anint,1,maxwav,1,n);*/
     free_vector(moisdc,1,n);
     free_vector(andc,1,n);
   
      
     wav=ivector(1,imx);
     dh=imatrix(1,lastpass-firstpass+1,1,imx);
     bh=imatrix(1,lastpass-firstpass+1,1,imx);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);
      
     /* Concatenates waves */
     concatwav(wav, dh, bh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);
   
     /* Routine tricode is to calculate cptcoveff (real number of unique covariates) and to associate covariable number and modality */
   
     Tcode=ivector(1,100);
     nbcode=imatrix(0,NCOVMAX,0,NCOVMAX); 
     ncodemax[1]=1;
     if (cptcovn > 0) tricode(Tvar,nbcode,imx);
         
     codtab=imatrix(1,100,1,10); /* Cross tabulation to get the order of 
                                    the estimations*/
     h=0;
     m=pow(2,cptcoveff);
    
     for(k=1;k<=cptcoveff; k++){
       for(i=1; i <=(m/pow(2,k));i++){
         for(j=1; j <= ncodemax[k]; j++){
           for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){
             h++;
             if (h>m) h=1;codtab[h][k]=j;codtab[h][Tvar[k]]=j;
             /*  printf("h=%d k=%d j=%d codtab[h][k]=%d tvar[k]=%d \n",h, k,j,codtab[h][k],Tvar[k]);*/
           } 
         }
       }
     } 
     /* printf("codtab[1][2]=%d codtab[2][2]=%d",codtab[1][2],codtab[2][2]); 
        codtab[1][2]=1;codtab[2][2]=2; */
     /* for(i=1; i <=m ;i++){ 
        for(k=1; k <=cptcovn; k++){
        printf("i=%d k=%d %d %d ",i,k,codtab[i][k], cptcoveff);
        }
        printf("\n");
        }
        scanf("%d",i);*/
       
     /*------------ gnuplot -------------*/
     strcpy(optionfilegnuplot,optionfilefiname);
     if(mle==-3)
       strcat(optionfilegnuplot,"-mort");
     strcat(optionfilegnuplot,".gp");
   
     if((ficgp=fopen(optionfilegnuplot,"w"))==NULL) {
       printf("Problem with file %s",optionfilegnuplot);
     }
     else{
       fprintf(ficgp,"\n# %s\n", version); 
       fprintf(ficgp,"# %s\n", optionfilegnuplot); 
       fprintf(ficgp,"set missing 'NaNq'\n");
     }
     /*  fclose(ficgp);*/
     /*--------- index.htm --------*/
   
     strcpy(optionfilehtm,optionfilefiname); /* Main html file */
     if(mle==-3)
       strcat(optionfilehtm,"-mort");
     strcat(optionfilehtm,".htm");
     if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtm), exit(0);
     }
   
     strcpy(optionfilehtmcov,optionfilefiname); /* Only for matrix of covariance */
     strcat(optionfilehtmcov,"-cov.htm");
     if((fichtmcov=fopen(optionfilehtmcov,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtmcov), exit(0);
     }
     else{
     fprintf(fichtmcov,"<body>\n<title>IMaCh Cov %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model);
     }
   
     fprintf(fichtm,"<body>\n<title>IMaCh %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n\
   \n\
   <hr  size=\"2\" color=\"#EC5E5E\">\
    <ul><li><h4>Parameter files</h4>\n\
    - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>\n\
    - Log file of the run: <a href=\"%s\">%s</a><br>\n\
    - Gnuplot file name: <a href=\"%s\">%s</a><br>\n\
    - Date and time at start: %s</ul>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model,\
             fileres,fileres,\
             filelog,filelog,optionfilegnuplot,optionfilegnuplot,strstart);
     fflush(fichtm);
   
     strcpy(pathr,path);
     strcat(pathr,optionfilefiname);
     chdir(optionfilefiname); /* Move to directory named optionfile */
     
     /* Calculates basic frequencies. Computes observed prevalence at single age
        and prints on file fileres'p'. */
     freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart);
   
     fprintf(fichtm,"\n");
     fprintf(fichtm,"<br>Total number of observations=%d <br>\n\
   Youngest age at first (selected) pass %.2f, oldest age %.2f<br>\n\
   Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>\n",\
             imx,agemin,agemax,jmin,jmax,jmean);
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */
       
      
     /* For Powell, parameters are in a vector p[] starting at p[1]
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */
   
     globpr=0; /* To get the number ipmx of contributions and the sum of weights*/
     if (mle==-3){
       ximort=matrix(1,NDIM,1,NDIM);
       cens=ivector(1,n);
       ageexmed=vector(1,n);
       agecens=vector(1,n);
       dcwave=ivector(1,n);
    
       for (i=1; i<=imx; i++){
         dcwave[i]=-1;
         for (j=1; j<=lastpass; j++)
           if (s[j][i]>nlstate) {
             dcwave[i]=j;
             /*    printf("i=%d j=%d s=%d dcwave=%d\n",i,j, s[j][i],dcwave[i]);*/
             break;
           }
       }
   
       for (i=1; i<=imx; i++) {
         if (wav[i]>0){
           ageexmed[i]=agev[mw[1][i]][i];
           j=wav[i];agecens[i]=1.; 
           if (ageexmed[i]>1 & wav[i]>0) agecens[i]=agev[mw[j][i]][i];
           cens[i]=1;
           
           if (ageexmed[i]<1) cens[i]=-1;
           if (agedc[i]< AGESUP & agedc[i]>1 & dcwave[i]>firstpass & dcwave[i]<=lastpass) cens[i]=0 ;
         }
         else cens[i]=-1;
       }
       
       for (i=1;i<=NDIM;i++) {
         for (j=1;j<=NDIM;j++)
           ximort[i][j]=(i == j ? 1.0 : 0.0);
       }
   
       p[1]=0.1; p[2]=0.1;
       /*printf("%lf %lf", p[1], p[2]);*/
       
       
     printf("Powell\n");  fprintf(ficlog,"Powell\n");
     strcpy(filerespow,"pow-mort"); 
     strcat(filerespow,fileres);
     if((ficrespow=fopen(filerespow,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", filerespow);
       fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
     }
     fprintf(ficrespow,"# Powell\n# iter -2*LL");
     /*  for (i=1;i<=nlstate;i++)
       for(j=1;j<=nlstate+ndeath;j++)
         if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
     */
     fprintf(ficrespow,"\n");
   
       powell(p,ximort,NDIM,ftol,&iter,&fret,gompertz);
       fclose(ficrespow);
       
       hesscov(matcov, p, NDIM,delti, 1e-4, gompertz); 
   
       for(i=1; i <=NDIM; i++)
         for(j=i+1;j<=NDIM;j++)
           matcov[i][j]=matcov[j][i];
       
       printf("\nCovariance matrix\n ");
       for(i=1; i <=NDIM; i++) {
         for(j=1;j<=NDIM;j++){ 
           printf("%f ",matcov[i][j]);
         }
         printf("\n ");
       }
       
       printf("iter=%d MLE=%f Eq=%lf*exp(%lf*(age-%d))\n",iter,-gompertz(p),p[1],p[2],agegomp);
       for (i=1;i<=NDIM;i++) 
         printf("%f [%f ; %f]\n",p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
   
   lsurv=vector(1,AGESUP);
       lpop=vector(1,AGESUP);
       tpop=vector(1,AGESUP);
       lsurv[agegomp]=100000;
      
        for (k=agegomp;k<=AGESUP;k++) {
         agemortsup=k;
         if (p[1]*exp(p[2]*(k-agegomp))>1) break;
       }
      
         for (k=agegomp;k<agemortsup;k++)
         lsurv[k+1]=lsurv[k]-lsurv[k]*(p[1]*exp(p[2]*(k-agegomp)));
   
       for (k=agegomp;k<agemortsup;k++){
         lpop[k]=(lsurv[k]+lsurv[k+1])/2.;
         sumlpop=sumlpop+lpop[k];
       }
   
    tpop[agegomp]=sumlpop;
       for (k=agegomp;k<(agemortsup-3);k++){
         /*  tpop[k+1]=2;*/
         tpop[k+1]=tpop[k]-lpop[k];
          }
      
      
          printf("\nAge   lx     qx    dx    Lx     Tx     e(x)\n");
       for (k=agegomp;k<(agemortsup-2);k++) 
         printf("%d %.0lf %lf %.0lf %.0lf %.0lf %lf\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
   
       replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
       printinggnuplotmort(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtmlmort(fileres,title,datafile, firstpass, lastpass, \
                        stepm, weightopt,\
                        model,imx,p,matcov,agemortsup);
   
       free_vector(lsurv,1,AGESUP);
       free_vector(lpop,1,AGESUP);
       free_vector(tpop,1,AGESUP);
     } /* Endof if mle==-3 */
   
     else{ /* For mle >=1 */
     
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("First Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       globpr=1; /* to print the contributions */
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("Second Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       if(mle>=1){ /* Could be 1 or 2 */
         mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);
       }
       
       /*--------- results files --------------*/
       fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle= 0 weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate, ndeath, maxwav, weightopt,model);
       
       
       fprintf(ficres,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       fprintf(ficlog,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(k=1; k <=(nlstate+ndeath); k++){
           if (k != i) {
             printf("%d%d ",i,k);
             fprintf(ficlog,"%d%d ",i,k);
             fprintf(ficres,"%1d%1d ",i,k);
             for(j=1; j <=ncovmodel; j++){
               printf("%f ",p[jk]);
               fprintf(ficlog,"%f ",p[jk]);
               fprintf(ficres,"%f ",p[jk]);
               jk++; 
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       if(mle!=0){
         /* Computing hessian and covariance matrix */
         ftolhess=ftol; /* Usually correct */
         hesscov(matcov, p, npar, delti, ftolhess, func);
       }
       fprintf(ficres,"# Scales (for hessian or gradient estimation)\n");
       printf("# Scales (for hessian or gradient estimation)\n");
       fprintf(ficlog,"# Scales (for hessian or gradient estimation)\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if (j!=i) {
             fprintf(ficres,"%1d%1d",i,j);
             printf("%1d%1d",i,j);
             fprintf(ficlog,"%1d%1d",i,j);
             for(k=1; k<=ncovmodel;k++){
               printf(" %.5e",delti[jk]);
               fprintf(ficlog," %.5e",delti[jk]);
               fprintf(ficres," %.5e",delti[jk]);
               jk++;
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       
       fprintf(ficres,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       if(mle>=1)
         printf("# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       fprintf(ficlog,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       /* # 121 Var(a12)\n\ */
       /* # 122 Cov(b12,a12) Var(b12)\n\ */
       /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
       /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
       /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
       /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
       /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
       /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
       
       
       /* Just to have a covariance matrix which will be more understandable
          even is we still don't want to manage dictionary of variables
       */
       for(itimes=1;itimes<=2;itimes++){
         jj=0;
         for(i=1; i <=nlstate; i++){
           for(j=1; j <=nlstate+ndeath; j++){
             if(j==i) continue;
             for(k=1; k<=ncovmodel;k++){
               jj++;
               ca[0]= k+'a'-1;ca[1]='\0';
               if(itimes==1){
                 if(mle>=1)
                   printf("#%1d%1d%d",i,j,k);
                 fprintf(ficlog,"#%1d%1d%d",i,j,k);
                 fprintf(ficres,"#%1d%1d%d",i,j,k);
               }else{
                 if(mle>=1)
                   printf("%1d%1d%d",i,j,k);
                 fprintf(ficlog,"%1d%1d%d",i,j,k);
                 fprintf(ficres,"%1d%1d%d",i,j,k);
               }
               ll=0;
               for(li=1;li <=nlstate; li++){
                 for(lj=1;lj <=nlstate+ndeath; lj++){
                   if(lj==li) continue;
                   for(lk=1;lk<=ncovmodel;lk++){
                     ll++;
                     if(ll<=jj){
                       cb[0]= lk +'a'-1;cb[1]='\0';
                       if(ll<jj){
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficlog," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficres," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }else{
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficlog," Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficres," Var(%s%1d%1d)",ca,i,j);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }
                     }
                   } /* end lk */
                 } /* end lj */
               } /* end li */
               if(mle>=1)
                 printf("\n");
               fprintf(ficlog,"\n");
               fprintf(ficres,"\n");
               numlinepar++;
             } /* end k*/
           } /*end j */
         } /* end i */
       } /* end itimes */
       
       fflush(ficlog);
       fflush(ficres);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       estepm=0;
       fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf estepm=%d\n",&ageminpar,&agemaxpar, &bage, &fage, &estepm);
       if (estepm==0 || estepm < stepm) estepm=stepm;
       if (fage <= 2) {
         bage = ageminpar;
         fage = agemaxpar;
       }
       
       fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");
       fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"begin-prev-date=%lf/%lf/%lf end-prev-date=%lf/%lf/%lf mov_average=%d\n",&jprev1, &mprev1,&anprev1,&jprev2, &mprev2,&anprev2,&mobilav);
       fprintf(ficparo,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficres,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       printf("begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficlog,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       
       dateprev1=anprev1+(mprev1-1)/12.+(jprev1-1)/365.;
       dateprev2=anprev2+(mprev2-1)/12.+(jprev2-1)/365.;
       
       fscanf(ficpar,"pop_based=%d\n",&popbased);
       fprintf(ficparo,"pop_based=%d\n",popbased);   
       fprintf(ficres,"pop_based=%d\n",popbased);   
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"prevforecast=%d starting-proj-date=%lf/%lf/%lf final-proj-date=%lf/%lf/%lf mobil_average=%d\n",&prevfcast,&jproj1,&mproj1,&anproj1,&jproj2,&mproj2,&anproj2,&mobilavproj);
       fprintf(ficparo,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       printf("prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficlog,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficres,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       /* day and month of proj2 are not used but only year anproj2.*/
       
       
       
       /*  freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);*/
       /*,dateprev1,dateprev2,jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
       
       replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
       printinggnuplot(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtml(fileres,title,datafile, firstpass, lastpass, stepm, weightopt,\
                    model,imx,jmin,jmax,jmean,rfileres,popforecast,estepm,\
                    jprev1,mprev1,anprev1,jprev2,mprev2,anprev2);
         
      /*------------ free_vector  -------------*/
      /*  chdir(path); */
    
       free_ivector(wav,1,imx);
       free_imatrix(dh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(bh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
       free_lvector(num,1,n);
       free_vector(agedc,1,n);
       /*free_matrix(covar,0,NCOVMAX,1,n);*/
       /*free_matrix(covar,1,NCOVMAX,1,n);*/
       fclose(ficparo);
       fclose(ficres);
   
   
       /*--------------- Prevalence limit  (stable prevalence) --------------*/
     
       strcpy(filerespl,"pl");
       strcat(filerespl,fileres);
       if((ficrespl=fopen(filerespl,"w"))==NULL) {
         printf("Problem with stable prevalence resultfile: %s\n", filerespl);goto end;
         fprintf(ficlog,"Problem with stable prevalence resultfile: %s\n", filerespl);goto end;
       }
       printf("Computing stable prevalence: result on file '%s' \n", filerespl);
       fprintf(ficlog,"Computing stable prevalence: result on file '%s' \n", filerespl);
       fprintf(ficrespl, "#Local time at start: %s", strstart);
       fprintf(ficrespl,"#Stable prevalence \n");
       fprintf(ficrespl,"#Age ");
       for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);
       fprintf(ficrespl,"\n");
     
       prlim=matrix(1,nlstate,1,nlstate);
   
       agebase=ageminpar;
       agelim=agemaxpar;
       ftolpl=1.e-10;
       i1=cptcoveff;
       if (cptcovn < 1){i1=1;}
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/
           fprintf(ficrespl,"\n#******");
           printf("\n#******");
           fprintf(ficlog,"\n#******");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             printf(" V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficlog," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficrespl,"******\n");
           printf("******\n");
           fprintf(ficlog,"******\n");
           
           for (age=agebase; age<=agelim; age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             fprintf(ficrespl,"%.0f ",age );
             for(j=1;j<=cptcoveff;j++)
               fprintf(ficrespl,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             for(i=1; i<=nlstate;i++)
               fprintf(ficrespl," %.5f", prlim[i][i]);
             fprintf(ficrespl,"\n");
           }
         }
       }
       fclose(ficrespl);
   
       /*------------- h Pij x at various ages ------------*/
     
       strcpy(filerespij,"pij");  strcat(filerespij,fileres);
       if((ficrespij=fopen(filerespij,"w"))==NULL) {
         printf("Problem with Pij resultfile: %s\n", filerespij);goto end;
         fprintf(ficlog,"Problem with Pij resultfile: %s\n", filerespij);goto end;
       }
       printf("Computing pij: result on file '%s' \n", filerespij);
       fprintf(ficlog,"Computing pij: result on file '%s' \n", filerespij);
     
       stepsize=(int) (stepm+YEARM-1)/YEARM;
       /*if (stepm<=24) stepsize=2;*/
   
       agelim=AGESUP;
       hstepm=stepsize*YEARM; /* Every year of age */
       hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */ 
   
       /* hstepm=1;   aff par mois*/
       fprintf(ficrespij, "#Local time at start: %s", strstart);
       fprintf(ficrespij,"#****** h Pij x Probability to be in state j at age x+h being in i at x ");
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficrespij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrespij,"******\n");
           
           for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
             nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
   
             /*      nhstepm=nhstepm*YEARM; aff par mois*/
   
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             fprintf(ficrespij,"# Cov Agex agex+h hpijx with i,j=");
             for(i=1; i<=nlstate;i++)
               for(j=1; j<=nlstate+ndeath;j++)
                 fprintf(ficrespij," %1d-%1d",i,j);
             fprintf(ficrespij,"\n");
             for (h=0; h<=nhstepm; h++){
               fprintf(ficrespij,"%d %3.f %3.f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );
               for(i=1; i<=nlstate;i++)
                 for(j=1; j<=nlstate+ndeath;j++)
                   fprintf(ficrespij," %.5f", p3mat[i][j][h]);
               fprintf(ficrespij,"\n");
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             fprintf(ficrespij,"\n");
           }
         }
       }
   
       varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax,strstart);
   
       fclose(ficrespij);
   
       probs= ma3x(1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
       for(i=1;i<=AGESUP;i++)
         for(j=1;j<=NCOVMAX;j++)
           for(k=1;k<=NCOVMAX;k++)
             probs[i][j][k]=0.;
   
       /*---------- Forecasting ------------------*/
       /*if((stepm == 1) && (strcmp(model,".")==0)){*/
       if(prevfcast==1){
         /*    if(stepm ==1){*/
         prevforecast(fileres, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff);
         /* (popforecast==1) populforecast(fileres, anpyram,mpyram,jpyram, agemin,agemax, dateprev1, dateprev2,mobilav, agedeb, fage, popforecast, popfile, anpyram1,p, i1);*/
         /*      }  */
         /*      else{ */
         /*        erreur=108; */
         /*        printf("Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*        fprintf(ficlog,"Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*      } */
       }
     
   
       /*---------- Health expectancies and variances ------------*/
   
       strcpy(filerest,"t");
       strcat(filerest,fileres);
       if((ficrest=fopen(filerest,"w"))==NULL) {
         printf("Problem with total LE resultfile: %s\n", filerest);goto end;
         fprintf(ficlog,"Problem with total LE resultfile: %s\n", filerest);goto end;
       }
       printf("Computing Total LEs with variances: file '%s' \n", filerest); 
       fprintf(ficlog,"Computing Total LEs with variances: file '%s' \n", filerest); 
   
   
       strcpy(filerese,"e");
       strcat(filerese,fileres);
       if((ficreseij=fopen(filerese,"w"))==NULL) {
         printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
         fprintf(ficlog,"Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
       }
       printf("Computing Health Expectancies: result on file '%s' \n", filerese);
       fprintf(ficlog,"Computing Health Expectancies: result on file '%s' \n", filerese);
   
       strcpy(fileresv,"v");
       strcat(fileresv,fileres);
       if((ficresvij=fopen(fileresv,"w"))==NULL) {
         printf("Problem with variance resultfile: %s\n", fileresv);exit(0);
         fprintf(ficlog,"Problem with variance resultfile: %s\n", fileresv);exit(0);
       }
       printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
       fprintf(ficlog,"Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
   
       /* Computes prevalence between agemin (i.e minimal age computed) and no more ageminpar */
       prevalence(probs, agemin, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
       /*  printf("ageminpar=%f, agemax=%f, s[lastpass][imx]=%d, agev[lastpass][imx]=%f, nlstate=%d, imx=%d,  mint[lastpass][imx]=%f, anint[lastpass][imx]=%f,dateprev1=%f, dateprev2=%f, firstpass=%d, lastpass=%d\n",\
           ageminpar, agemax, s[lastpass][imx], agev[lastpass][imx], nlstate, imx, mint[lastpass][imx],anint[lastpass][imx], dateprev1, dateprev2, firstpass, lastpass);
       */
   
       if (mobilav!=0) {
         mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
         if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
           fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
           printf(" Error in movingaverage mobilav=%d\n",mobilav);
         }
       }
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1; 
           fprintf(ficrest,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrest,"******\n");
   
           fprintf(ficreseij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficreseij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficreseij,"******\n");
   
           fprintf(ficresvij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvij,"******\n");
   
           eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, delti, matcov, strstart);  
    
           vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,0, mobilav, strstart);
           if(popbased==1){
             varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,popbased,mobilav, strstart);
           }
   
           fprintf(ficrest, "#Local time at start: %s", strstart);
           fprintf(ficrest,"#Total LEs with variances: e.. (std) ");
           for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);
           fprintf(ficrest,"\n");
   
           epj=vector(1,nlstate+1);
           for(age=bage; age <=fage ;age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             if (popbased==1) {
               if(mobilav ==0){
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=probs[(int)age][i][k];
               }else{ /* mobilav */ 
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=mobaverage[(int)age][i][k];
               }
             }
           
             fprintf(ficrest," %4.0f",age);
             for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){
               for(i=1, epj[j]=0.;i <=nlstate;i++) {
                 epj[j] += prlim[i][i]*eij[i][j][(int)age];
                 /*  printf("%lf %lf ", prlim[i][i] ,eij[i][j][(int)age]);*/
               }
               epj[nlstate+1] +=epj[j];
             }
   
             for(i=1, vepp=0.;i <=nlstate;i++)
               for(j=1;j <=nlstate;j++)
                 vepp += vareij[i][j][(int)age];
             fprintf(ficrest," %7.3f (%7.3f)", epj[nlstate+1],sqrt(vepp));
             for(j=1;j <=nlstate;j++){
               fprintf(ficrest," %7.3f (%7.3f)", epj[j],sqrt(vareij[j][j][(int)age]));
             }
             fprintf(ficrest,"\n");
           }
           free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_vector(epj,1,nlstate+1);
         }
       }
       free_vector(weight,1,n);
       free_imatrix(Tvard,1,15,1,2);
       free_imatrix(s,1,maxwav+1,1,n);
       free_matrix(anint,1,maxwav,1,n); 
       free_matrix(mint,1,maxwav,1,n);
       free_ivector(cod,1,n);
       free_ivector(tab,1,NCOVMAX);
       fclose(ficreseij);
       fclose(ficresvij);
       fclose(ficrest);
       fclose(ficpar);
     
       /*------- Variance of stable prevalence------*/   
   
       strcpy(fileresvpl,"vpl");
       strcat(fileresvpl,fileres);
       if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {
         printf("Problem with variance of stable prevalence  resultfile: %s\n", fileresvpl);
         exit(0);
       }
       printf("Computing Variance-covariance of stable prevalence: file '%s' \n", fileresvpl);
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficresvpl,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvpl,"******\n");
         
           varpl=matrix(1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k,strstart);
           free_matrix(varpl,1,nlstate,(int) bage, (int)fage);
         }
       }
   
       fclose(ficresvpl);
   
       /*---------- End : free ----------------*/
       if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       free_ma3x(probs,1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     }  /* mle==-3 arrives here for freeing */
       free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);
     
       free_matrix(covar,0,NCOVMAX,1,n);
       free_matrix(matcov,1,npar,1,npar);
       /*free_vector(delti,1,npar);*/
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       free_matrix(agev,1,maxwav,1,imx);
       free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);
   
       free_ivector(ncodemax,1,8);
       free_ivector(Tvar,1,15);
       free_ivector(Tprod,1,15);
       free_ivector(Tvaraff,1,15);
       free_ivector(Tage,1,15);
       free_ivector(Tcode,1,100);
   
   
     fflush(fichtm);
     fflush(ficgp);
     
   
     if((nberr >0) || (nbwarn>0)){
       printf("End of Imach with %d errors and/or %d warnings\n",nberr,nbwarn);
       fprintf(ficlog,"End of Imach with %d errors and/or warnings %d\n",nberr,nbwarn);
     }else{
       printf("End of Imach\n");
       fprintf(ficlog,"End of Imach\n");
     }
     printf("See log file on %s\n",filelog);
     /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */
     (void) gettimeofday(&end_time,&tzp);
     tm = *localtime(&end_time.tv_sec);
     tmg = *gmtime(&end_time.tv_sec);
     strcpy(strtend,asctime(&tm));
     printf("Local time at start %s\nLocal time at end   %s",strstart, strtend); 
     fprintf(ficlog,"Local time at start %s\nLocal time at end   %s\n",strstart, strtend); 
     printf("Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
   
     printf("Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     fprintf(ficlog,"Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
     fprintf(ficlog,"Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     /*  printf("Total time was %d uSec.\n", total_usecs);*/
   /*   if(fileappend(fichtm,optionfilehtm)){ */
     fprintf(fichtm,"<br>Local time at start %s<br>Local time at end   %s<br>",strstart, strtend);
     fclose(fichtm);
     fclose(fichtmcov);
     fclose(ficgp);
     fclose(ficlog);
     /*------ End -----------*/
   
     chdir(path);
   #ifndef UNIX
     strcpy(plotcmd,"\"");
   #endif
     strcat(plotcmd,pathimach);
     /*strcat(plotcmd,CHARSEPARATOR);*/
     strcat(plotcmd,GNUPLOTPROGRAM);
   #ifndef UNIX
     strcat(plotcmd,"\"");
   #endif
     if(stat(plotcmd,&info)){
       printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
     }
     strcat(plotcmd," ");
     strcat(plotcmd,optionfilegnuplot);
     printf("Starting graphs with: %s",plotcmd);fflush(stdout);
   
     if((outcmd=system(plotcmd)) != 0){
       printf(" Problem with gnuplot\n");
     }
     printf(" Wait...");
     while (z[0] != 'q') {
       /* chdir(path); */
       printf("\nType e to edit output files, g to graph again and q for exiting: ");
       scanf("%s",z);
   /*     if (z[0] == 'c') system("./imach"); */
       if (z[0] == 'e') {
         printf("Starting browser with: %s",optionfilehtm);fflush(stdout);
         system(optionfilehtm);
       }
       else if (z[0] == 'g') system(plotcmd);
       else if (z[0] == 'q') exit(0);
     }
     end:
     while (z[0] != 'q') {
       printf("\nType  q for exiting: ");
       scanf("%s",z);
     }
   }
   
   
   

Removed from v.1.18  
changed lines
  Added in v.1.107


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