Diff for /imach/src/imach.c between versions 1.11 and 1.121

version 1.11, 2001/05/17 16:07:14 version 1.121, 2006/03/16 17:45:01
Line 1 Line 1
      /* $Id$
 /*********************** Imach **************************************            $State$
   This program computes Healthy Life Expectancies from cross-longitudinal    $Log$
   data. Cross-longitudinal consist in a first survey ("cross") where    Revision 1.121  2006/03/16 17:45:01  lievre
   individuals from different ages are interviewed on their health status    * imach.c (Module): Comments concerning covariates added
   or degree of  disability. At least a second wave of interviews  
   ("longitudinal") should  measure each new individual health status.    * imach.c (Module): refinements in the computation of lli if
   Health expectancies are computed from the transistions observed between    status=-2 in order to have more reliable computation if stepm is
   waves and are computed for each degree of severity of disability (number    not 1 month. Version 0.98f
   of life states). More degrees you consider, more time is necessary to  
   reach the Maximum Likelihood of the parameters involved in the model.    Revision 1.120  2006/03/16 15:10:38  lievre
   The simplest model is the multinomial logistic model where pij is    (Module): refinements in the computation of lli if
   the probabibility to be observed in state j at the second wave conditional    status=-2 in order to have more reliable computation if stepm is
   to be observed in state i at the first wave. Therefore the model is:    not 1 month. Version 0.98f
   log(pij/pii)= aij + bij*age+ cij*sex + etc , where 'age' is age and 'sex'  
   is a covariate. If you want to have a more complex model than "constant and    Revision 1.119  2006/03/15 17:42:26  brouard
   age", you should modify the program where the markup    (Module): Bug if status = -2, the loglikelihood was
     *Covariates have to be included here again* invites you to do it.    computed as likelihood omitting the logarithm. Version O.98e
   More covariates you add, less is the speed of the convergence.  
     Revision 1.118  2006/03/14 18:20:07  brouard
   The advantage that this computer programme claims, comes from that if the    (Module): varevsij Comments added explaining the second
   delay between waves is not identical for each individual, or if some    table of variances if popbased=1 .
   individual missed an interview, the information is not rounded or lost, but    (Module): Covariances of eij, ekl added, graphs fixed, new html link.
   taken into account using an interpolation or extrapolation.    (Module): Function pstamp added
   hPijx is the probability to be    (Module): Version 0.98d
   observed in state i at age x+h conditional to the observed state i at age  
   x. The delay 'h' can be split into an exact number (nh*stepm) of    Revision 1.117  2006/03/14 17:16:22  brouard
   unobserved intermediate  states. This elementary transition (by month or    (Module): varevsij Comments added explaining the second
   quarter trimester, semester or year) is model as a multinomial logistic.    table of variances if popbased=1 .
   The hPx matrix is simply the matrix product of nh*stepm elementary matrices    (Module): Covariances of eij, ekl added, graphs fixed, new html link.
   and the contribution of each individual to the likelihood is simply hPijx.    (Module): Function pstamp added
     (Module): Version 0.98d
   Also this programme outputs the covariance matrix of the parameters but also  
   of the life expectancies. It also computes the prevalence limits.    Revision 1.116  2006/03/06 10:29:27  brouard
      (Module): Variance-covariance wrong links and
   Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).    varian-covariance of ej. is needed (Saito).
            Institut national d'études démographiques, Paris.  
   This software have been partly granted by Euro-REVES, a concerted action    Revision 1.115  2006/02/27 12:17:45  brouard
   from the European Union.    (Module): One freematrix added in mlikeli! 0.98c
   It is copyrighted identically to a GNU software product, ie programme and  
   software can be distributed freely for non commercial use. Latest version    Revision 1.114  2006/02/26 12:57:58  brouard
   can be accessed at http://euroreves.ined.fr/imach .    (Module): Some improvements in processing parameter
   **********************************************************************/    filename with strsep.
    
 #include <math.h>    Revision 1.113  2006/02/24 14:20:24  brouard
 #include <stdio.h>    (Module): Memory leaks checks with valgrind and:
 #include <stdlib.h>    datafile was not closed, some imatrix were not freed and on matrix
 #include <unistd.h>    allocation too.
   
 #define MAXLINE 256    Revision 1.112  2006/01/30 09:55:26  brouard
 #define FILENAMELENGTH 80    (Module): Back to gnuplot.exe instead of wgnuplot.exe
 /*#define DEBUG*/  
 #define windows    Revision 1.111  2006/01/25 20:38:18  brouard
 #define GLOCK_ERROR_NOPATH              -1      /* empty path */    (Module): Lots of cleaning and bugs added (Gompertz)
 #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */    (Module): Comments can be added in data file. Missing date values
     can be a simple dot '.'.
 #define MAXPARM 30 /* Maximum number of parameters for the optimization */  
 #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */    Revision 1.110  2006/01/25 00:51:50  brouard
     (Module): Lots of cleaning and bugs added (Gompertz)
 #define NINTERVMAX 8  
 #define NLSTATEMAX 8 /* Maximum number of live states (for func) */    Revision 1.109  2006/01/24 19:37:15  brouard
 #define NDEATHMAX 8 /* Maximum number of dead states (for func) */    (Module): Comments (lines starting with a #) are allowed in data.
 #define NCOVMAX 8 /* Maximum number of covariates */  
 #define MAXN 20000    Revision 1.108  2006/01/19 18:05:42  lievre
 #define YEARM 12. /* Number of months per year */    Gnuplot problem appeared...
 #define AGESUP 130    To be fixed
 #define AGEBASE 40  
     Revision 1.107  2006/01/19 16:20:37  brouard
     Test existence of gnuplot in imach path
 int nvar;  
 int cptcovn, cptcovage=0, cptcoveff=0,cptcov;    Revision 1.106  2006/01/19 13:24:36  brouard
 int npar=NPARMAX;    Some cleaning and links added in html output
 int nlstate=2; /* Number of live states */  
 int ndeath=1; /* Number of dead states */    Revision 1.105  2006/01/05 20:23:19  lievre
 int ncovmodel, ncov;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */    *** empty log message ***
   
 int *wav; /* Number of waves for this individuual 0 is possible */    Revision 1.104  2005/09/30 16:11:43  lievre
 int maxwav; /* Maxim number of waves */    (Module): sump fixed, loop imx fixed, and simplifications.
 int jmin, jmax; /* min, max spacing between 2 waves */    (Module): If the status is missing at the last wave but we know
 int mle, weightopt;    that the person is alive, then we can code his/her status as -2
 int **mw; /* mw[mi][i] is number of the mi wave for this individual */    (instead of missing=-1 in earlier versions) and his/her
 int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */    contributions to the likelihood is 1 - Prob of dying from last
 double jmean; /* Mean space between 2 waves */    health status (= 1-p13= p11+p12 in the easiest case of somebody in
 double **oldm, **newm, **savm; /* Working pointers to matrices */    the healthy state at last known wave). Version is 0.98
 double **oldms, **newms, **savms; /* Fixed working pointers to matrices */  
 FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest;    Revision 1.103  2005/09/30 15:54:49  lievre
 FILE *ficgp, *fichtm;    (Module): sump fixed, loop imx fixed, and simplifications.
 FILE *ficreseij;  
   char filerese[FILENAMELENGTH];    Revision 1.102  2004/09/15 17:31:30  brouard
  FILE  *ficresvij;    Add the possibility to read data file including tab characters.
   char fileresv[FILENAMELENGTH];  
  FILE  *ficresvpl;    Revision 1.101  2004/09/15 10:38:38  brouard
   char fileresvpl[FILENAMELENGTH];    Fix on curr_time
   
 #define NR_END 1    Revision 1.100  2004/07/12 18:29:06  brouard
 #define FREE_ARG char*    Add version for Mac OS X. Just define UNIX in Makefile
 #define FTOL 1.0e-10  
     Revision 1.99  2004/06/05 08:57:40  brouard
 #define NRANSI    *** empty log message ***
 #define ITMAX 200  
     Revision 1.98  2004/05/16 15:05:56  brouard
 #define TOL 2.0e-4    New version 0.97 . First attempt to estimate force of mortality
     directly from the data i.e. without the need of knowing the health
 #define CGOLD 0.3819660    state at each age, but using a Gompertz model: log u =a + b*age .
 #define ZEPS 1.0e-10    This is the basic analysis of mortality and should be done before any
 #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d);    other analysis, in order to test if the mortality estimated from the
     cross-longitudinal survey is different from the mortality estimated
 #define GOLD 1.618034    from other sources like vital statistic data.
 #define GLIMIT 100.0  
 #define TINY 1.0e-20    The same imach parameter file can be used but the option for mle should be -3.
   
 static double maxarg1,maxarg2;    Agnès, who wrote this part of the code, tried to keep most of the
 #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))    former routines in order to include the new code within the former code.
 #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))  
      The output is very simple: only an estimate of the intercept and of
 #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))    the slope with 95% confident intervals.
 #define rint(a) floor(a+0.5)  
     Current limitations:
 static double sqrarg;    A) Even if you enter covariates, i.e. with the
 #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)    model= V1+V2 equation for example, the programm does only estimate a unique global model without covariates.
 #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;}    B) There is no computation of Life Expectancy nor Life Table.
   
 int imx;    Revision 1.97  2004/02/20 13:25:42  lievre
 int stepm;    Version 0.96d. Population forecasting command line is (temporarily)
 /* Stepm, step in month: minimum step interpolation*/    suppressed.
   
 int m,nb;    Revision 1.96  2003/07/15 15:38:55  brouard
 int *num, firstpass=0, lastpass=4,*cod, *ncodemax, *Tage;    * imach.c (Repository): Errors in subdirf, 2, 3 while printing tmpout is
 double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;    rewritten within the same printf. Workaround: many printfs.
 double **pmmij;  
     Revision 1.95  2003/07/08 07:54:34  brouard
 double *weight;    * imach.c (Repository):
 int **s; /* Status */    (Repository): Using imachwizard code to output a more meaningful covariance
 double *agedc, **covar, idx;    matrix (cov(a12,c31) instead of numbers.
 int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;  
     Revision 1.94  2003/06/27 13:00:02  brouard
 double ftol=FTOL; /* Tolerance for computing Max Likelihood */    Just cleaning
 double ftolhess; /* Tolerance for computing hessian */  
     Revision 1.93  2003/06/25 16:33:55  brouard
 /**************** split *************************/    (Module): On windows (cygwin) function asctime_r doesn't
 static  int split( char *path, char *dirc, char *name )    exist so I changed back to asctime which exists.
 {    (Module): Version 0.96b
    char *s;                             /* pointer */  
    int  l1, l2;                         /* length counters */    Revision 1.92  2003/06/25 16:30:45  brouard
     (Module): On windows (cygwin) function asctime_r doesn't
    l1 = strlen( path );                 /* length of path */    exist so I changed back to asctime which exists.
    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );  
    s = strrchr( path, '\\' );           /* find last / */    Revision 1.91  2003/06/25 15:30:29  brouard
    if ( s == NULL ) {                   /* no directory, so use current */    * imach.c (Repository): Duplicated warning errors corrected.
 #if     defined(__bsd__)                /* get current working directory */    (Repository): Elapsed time after each iteration is now output. It
       extern char       *getwd( );    helps to forecast when convergence will be reached. Elapsed time
     is stamped in powell.  We created a new html file for the graphs
       if ( getwd( dirc ) == NULL ) {    concerning matrix of covariance. It has extension -cov.htm.
 #else  
       extern char       *getcwd( );    Revision 1.90  2003/06/24 12:34:15  brouard
     (Module): Some bugs corrected for windows. Also, when
       if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {    mle=-1 a template is output in file "or"mypar.txt with the design
 #endif    of the covariance matrix to be input.
          return( GLOCK_ERROR_GETCWD );  
       }    Revision 1.89  2003/06/24 12:30:52  brouard
       strcpy( name, path );             /* we've got it */    (Module): Some bugs corrected for windows. Also, when
    } else {                             /* strip direcotry from path */    mle=-1 a template is output in file "or"mypar.txt with the design
       s++;                              /* after this, the filename */    of the covariance matrix to be input.
       l2 = strlen( s );                 /* length of filename */  
       if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );    Revision 1.88  2003/06/23 17:54:56  brouard
       strcpy( name, s );                /* save file name */    * imach.c (Repository): Create a sub-directory where all the secondary files are. Only imach, htm, gp and r(imach) are on the main directory. Correct time and other things.
       strncpy( dirc, path, l1 - l2 );   /* now the directory */  
       dirc[l1-l2] = 0;                  /* add zero */    Revision 1.87  2003/06/18 12:26:01  brouard
    }    Version 0.96
    l1 = strlen( dirc );                 /* length of directory */  
    if ( dirc[l1-1] != '\\' ) { dirc[l1] = '\\'; dirc[l1+1] = 0; }    Revision 1.86  2003/06/17 20:04:08  brouard
    return( 0 );                         /* we're done */    (Module): Change position of html and gnuplot routines and added
 }    routine fileappend.
   
     Revision 1.85  2003/06/17 13:12:43  brouard
 /******************************************/    * imach.c (Repository): Check when date of death was earlier that
     current date of interview. It may happen when the death was just
 void replace(char *s, char*t)    prior to the death. In this case, dh was negative and likelihood
 {    was wrong (infinity). We still send an "Error" but patch by
   int i;    assuming that the date of death was just one stepm after the
   int lg=20;    interview.
   i=0;    (Repository): Because some people have very long ID (first column)
   lg=strlen(t);    we changed int to long in num[] and we added a new lvector for
   for(i=0; i<= lg; i++) {    memory allocation. But we also truncated to 8 characters (left
     (s[i] = t[i]);    truncation)
     if (t[i]== '\\') s[i]='/';    (Repository): No more line truncation errors.
   }  
 }    Revision 1.84  2003/06/13 21:44:43  brouard
     * imach.c (Repository): Replace "freqsummary" at a correct
 int nbocc(char *s, char occ)    place. It differs from routine "prevalence" which may be called
 {    many times. Probs is memory consuming and must be used with
   int i,j=0;    parcimony.
   int lg=20;    Version 0.95a3 (should output exactly the same maximization than 0.8a2)
   i=0;  
   lg=strlen(s);    Revision 1.83  2003/06/10 13:39:11  lievre
   for(i=0; i<= lg; i++) {    *** empty log message ***
   if  (s[i] == occ ) j++;  
   }    Revision 1.82  2003/06/05 15:57:20  brouard
   return j;    Add log in  imach.c and  fullversion number is now printed.
 }  
   */
 void cutv(char *u,char *v, char*t, char occ)  /*
 {     Interpolated Markov Chain
   int i,lg,j,p=0;  
   i=0;    Short summary of the programme:
   for(j=0; j<=strlen(t)-1; j++) {    
     if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;    This program computes Healthy Life Expectancies from
   }    cross-longitudinal data. Cross-longitudinal data consist in: -1- a
     first survey ("cross") where individuals from different ages are
   lg=strlen(t);    interviewed on their health status or degree of disability (in the
   for(j=0; j<p; j++) {    case of a health survey which is our main interest) -2- at least a
     (u[j] = t[j]);    second wave of interviews ("longitudinal") which measure each change
   }    (if any) in individual health status.  Health expectancies are
      u[p]='\0';    computed from the time spent in each health state according to a
     model. More health states you consider, more time is necessary to reach the
    for(j=0; j<= lg; j++) {    Maximum Likelihood of the parameters involved in the model.  The
     if (j>=(p+1))(v[j-p-1] = t[j]);    simplest model is the multinomial logistic model where pij is the
   }    probability to be observed in state j at the second wave
 }    conditional to be observed in state i at the first wave. Therefore
     the model is: log(pij/pii)= aij + bij*age+ cij*sex + etc , where
 /********************** nrerror ********************/    'age' is age and 'sex' is a covariate. If you want to have a more
     complex model than "constant and age", you should modify the program
 void nrerror(char error_text[])    where the markup *Covariates have to be included here again* invites
 {    you to do it.  More covariates you add, slower the
   fprintf(stderr,"ERREUR ...\n");    convergence.
   fprintf(stderr,"%s\n",error_text);  
   exit(1);    The advantage of this computer programme, compared to a simple
 }    multinomial logistic model, is clear when the delay between waves is not
 /*********************** vector *******************/    identical for each individual. Also, if a individual missed an
 double *vector(int nl, int nh)    intermediate interview, the information is lost, but taken into
 {    account using an interpolation or extrapolation.  
   double *v;  
   v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));    hPijx is the probability to be observed in state i at age x+h
   if (!v) nrerror("allocation failure in vector");    conditional to the observed state i at age x. The delay 'h' can be
   return v-nl+NR_END;    split into an exact number (nh*stepm) of unobserved intermediate
 }    states. This elementary transition (by month, quarter,
     semester or year) is modelled as a multinomial logistic.  The hPx
 /************************ free vector ******************/    matrix is simply the matrix product of nh*stepm elementary matrices
 void free_vector(double*v, int nl, int nh)    and the contribution of each individual to the likelihood is simply
 {    hPijx.
   free((FREE_ARG)(v+nl-NR_END));  
 }    Also this programme outputs the covariance matrix of the parameters but also
     of the life expectancies. It also computes the period (stable) prevalence. 
 /************************ivector *******************************/    
 int *ivector(long nl,long nh)    Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).
 {             Institut national d'études démographiques, Paris.
   int *v;    This software have been partly granted by Euro-REVES, a concerted action
   v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));    from the European Union.
   if (!v) nrerror("allocation failure in ivector");    It is copyrighted identically to a GNU software product, ie programme and
   return v-nl+NR_END;    software can be distributed freely for non commercial use. Latest version
 }    can be accessed at http://euroreves.ined.fr/imach .
   
 /******************free ivector **************************/    Help to debug: LD_PRELOAD=/usr/local/lib/libnjamd.so ./imach foo.imach
 void free_ivector(int *v, long nl, long nh)    or better on gdb : set env LD_PRELOAD=/usr/local/lib/libnjamd.so
 {    
   free((FREE_ARG)(v+nl-NR_END));    **********************************************************************/
 }  /*
     main
 /******************* imatrix *******************************/    read parameterfile
 int **imatrix(long nrl, long nrh, long ncl, long nch)    read datafile
      /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */    concatwav
 {    freqsummary
   long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;    if (mle >= 1)
   int **m;      mlikeli
      print results files
   /* allocate pointers to rows */    if mle==1 
   m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*)));       computes hessian
   if (!m) nrerror("allocation failure 1 in matrix()");    read end of parameter file: agemin, agemax, bage, fage, estepm
   m += NR_END;        begin-prev-date,...
   m -= nrl;    open gnuplot file
      open html file
      period (stable) prevalence
   /* allocate rows and set pointers to them */     for age prevalim()
   m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int)));    h Pij x
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");    variance of p varprob
   m[nrl] += NR_END;    forecasting if prevfcast==1 prevforecast call prevalence()
   m[nrl] -= ncl;    health expectancies
      Variance-covariance of DFLE
   for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;    prevalence()
       movingaverage()
   /* return pointer to array of pointers to rows */    varevsij() 
   return m;    if popbased==1 varevsij(,popbased)
 }    total life expectancies
     Variance of period (stable) prevalence
 /****************** free_imatrix *************************/   end
 void free_imatrix(m,nrl,nrh,ncl,nch)  */
       int **m;  
       long nch,ncl,nrh,nrl;  
      /* free an int matrix allocated by imatrix() */  
 {   
   free((FREE_ARG) (m[nrl]+ncl-NR_END));  #include <math.h>
   free((FREE_ARG) (m+nrl-NR_END));  #include <stdio.h>
 }  #include <stdlib.h>
   #include <string.h>
 /******************* matrix *******************************/  #include <unistd.h>
 double **matrix(long nrl, long nrh, long ncl, long nch)  
 {  #include <limits.h>
   long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;  #include <sys/types.h>
   double **m;  #include <sys/stat.h>
   #include <errno.h>
   m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  extern int errno;
   if (!m) nrerror("allocation failure 1 in matrix()");  
   m += NR_END;  /* #include <sys/time.h> */
   m -= nrl;  #include <time.h>
   #include "timeval.h"
   m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  /* #include <libintl.h> */
   m[nrl] += NR_END;  /* #define _(String) gettext (String) */
   m[nrl] -= ncl;  
   #define MAXLINE 256
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  
   return m;  #define GNUPLOTPROGRAM "gnuplot"
 }  /*#define GNUPLOTPROGRAM "..\\gp37mgw\\wgnuplot"*/
   #define FILENAMELENGTH 132
 /*************************free matrix ************************/  
 void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)  #define GLOCK_ERROR_NOPATH              -1      /* empty path */
 {  #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  
   free((FREE_ARG)(m+nrl-NR_END));  #define MAXPARM 30 /* Maximum number of parameters for the optimization */
 }  #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */
   
 /******************* ma3x *******************************/  #define NINTERVMAX 8
 double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)  #define NLSTATEMAX 8 /* Maximum number of live states (for func) */
 {  #define NDEATHMAX 8 /* Maximum number of dead states (for func) */
   long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;  #define NCOVMAX 8 /* Maximum number of covariates */
   double ***m;  #define MAXN 20000
   #define YEARM 12. /* Number of months per year */
   m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  #define AGESUP 130
   if (!m) nrerror("allocation failure 1 in matrix()");  #define AGEBASE 40
   m += NR_END;  #define AGEGOMP 10. /* Minimal age for Gompertz adjustment */
   m -= nrl;  #ifdef UNIX
   #define DIRSEPARATOR '/'
   m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  #define CHARSEPARATOR "/"
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  #define ODIRSEPARATOR '\\'
   m[nrl] += NR_END;  #else
   m[nrl] -= ncl;  #define DIRSEPARATOR '\\'
   #define CHARSEPARATOR "\\"
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  #define ODIRSEPARATOR '/'
   #endif
   m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));  
   if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");  /* $Id$ */
   m[nrl][ncl] += NR_END;  /* $State$ */
   m[nrl][ncl] -= nll;  
   for (j=ncl+1; j<=nch; j++)  char version[]="Imach version 0.98f, March 2006, INED-EUROREVES-Institut de longevite ";
     m[nrl][j]=m[nrl][j-1]+nlay;  char fullversion[]="$Revision$ $Date$"; 
    char strstart[80];
   for (i=nrl+1; i<=nrh; i++) {  char optionfilext[10], optionfilefiname[FILENAMELENGTH];
     m[i][ncl]=m[i-1l][ncl]+ncol*nlay;  int erreur, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings  */
     for (j=ncl+1; j<=nch; j++)  int nvar;
       m[i][j]=m[i][j-1]+nlay;  int cptcovn=0, cptcovage=0, cptcoveff=0,cptcov;
   }  int npar=NPARMAX;
   return m;  int nlstate=2; /* Number of live states */
 }  int ndeath=1; /* Number of dead states */
   int ncovmodel, ncovcol;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */
 /*************************free ma3x ************************/  int popbased=0;
 void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)  
 {  int *wav; /* Number of waves for this individuual 0 is possible */
   free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));  int maxwav; /* Maxim number of waves */
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  int jmin, jmax; /* min, max spacing between 2 waves */
   free((FREE_ARG)(m+nrl-NR_END));  int ijmin, ijmax; /* Individuals having jmin and jmax */ 
 }  int gipmx, gsw; /* Global variables on the number of contributions 
                      to the likelihood and the sum of weights (done by funcone)*/
 /***************** f1dim *************************/  int mle, weightopt;
 extern int ncom;  int **mw; /* mw[mi][i] is number of the mi wave for this individual */
 extern double *pcom,*xicom;  int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */
 extern double (*nrfunc)(double []);  int **bh; /* bh[mi][i] is the bias (+ or -) for this individual if the delay between
               * wave mi and wave mi+1 is not an exact multiple of stepm. */
 double f1dim(double x)  double jmean; /* Mean space between 2 waves */
 {  double **oldm, **newm, **savm; /* Working pointers to matrices */
   int j;  double **oldms, **newms, **savms; /* Fixed working pointers to matrices */
   double f;  FILE *fic,*ficpar, *ficparo,*ficres, *ficresp, *ficrespl, *ficrespij, *ficrest,*ficresf,*ficrespop;
   double *xt;  FILE *ficlog, *ficrespow;
    int globpr; /* Global variable for printing or not */
   xt=vector(1,ncom);  double fretone; /* Only one call to likelihood */
   for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j];  long ipmx; /* Number of contributions */
   f=(*nrfunc)(xt);  double sw; /* Sum of weights */
   free_vector(xt,1,ncom);  char filerespow[FILENAMELENGTH];
   return f;  char fileresilk[FILENAMELENGTH]; /* File of individual contributions to the likelihood */
 }  FILE *ficresilk;
   FILE *ficgp,*ficresprob,*ficpop, *ficresprobcov, *ficresprobcor;
 /*****************brent *************************/  FILE *ficresprobmorprev;
 double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin)  FILE *fichtm, *fichtmcov; /* Html File */
 {  FILE *ficreseij;
   int iter;  char filerese[FILENAMELENGTH];
   double a,b,d,etemp;  FILE *ficresstdeij;
   double fu,fv,fw,fx;  char fileresstde[FILENAMELENGTH];
   double ftemp;  FILE *ficrescveij;
   double p,q,r,tol1,tol2,u,v,w,x,xm;  char filerescve[FILENAMELENGTH];
   double e=0.0;  FILE  *ficresvij;
    char fileresv[FILENAMELENGTH];
   a=(ax < cx ? ax : cx);  FILE  *ficresvpl;
   b=(ax > cx ? ax : cx);  char fileresvpl[FILENAMELENGTH];
   x=w=v=bx;  char title[MAXLINE];
   fw=fv=fx=(*f)(x);  char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];
   for (iter=1;iter<=ITMAX;iter++) {  char plotcmd[FILENAMELENGTH], pplotcmd[FILENAMELENGTH];
     xm=0.5*(a+b);  char tmpout[FILENAMELENGTH],  tmpout2[FILENAMELENGTH]; 
     tol2=2.0*(tol1=tol*fabs(x)+ZEPS);  char command[FILENAMELENGTH];
     /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/  int  outcmd=0;
     printf(".");fflush(stdout);  
 #ifdef DEBUG  char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], rfileres[FILENAMELENGTH];
     printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);  
     /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */  char filelog[FILENAMELENGTH]; /* Log file */
 #endif  char filerest[FILENAMELENGTH];
     if (fabs(x-xm) <= (tol2-0.5*(b-a))){  char fileregp[FILENAMELENGTH];
       *xmin=x;  char popfile[FILENAMELENGTH];
       return fx;  
     }  char optionfilegnuplot[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH], optionfilehtmcov[FILENAMELENGTH] ;
     ftemp=fu;  
     if (fabs(e) > tol1) {  struct timeval start_time, end_time, curr_time, last_time, forecast_time;
       r=(x-w)*(fx-fv);  struct timezone tzp;
       q=(x-v)*(fx-fw);  extern int gettimeofday();
       p=(x-v)*q-(x-w)*r;  struct tm tmg, tm, tmf, *gmtime(), *localtime();
       q=2.0*(q-r);  long time_value;
       if (q > 0.0) p = -p;  extern long time();
       q=fabs(q);  char strcurr[80], strfor[80];
       etemp=e;  
       e=d;  char *endptr;
       if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x))  long lval;
         d=CGOLD*(e=(x >= xm ? a-x : b-x));  
       else {  #define NR_END 1
         d=p/q;  #define FREE_ARG char*
         u=x+d;  #define FTOL 1.0e-10
         if (u-a < tol2 || b-u < tol2)  
           d=SIGN(tol1,xm-x);  #define NRANSI 
       }  #define ITMAX 200 
     } else {  
       d=CGOLD*(e=(x >= xm ? a-x : b-x));  #define TOL 2.0e-4 
     }  
     u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d));  #define CGOLD 0.3819660 
     fu=(*f)(u);  #define ZEPS 1.0e-10 
     if (fu <= fx) {  #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d); 
       if (u >= x) a=x; else b=x;  
       SHFT(v,w,x,u)  #define GOLD 1.618034 
         SHFT(fv,fw,fx,fu)  #define GLIMIT 100.0 
         } else {  #define TINY 1.0e-20 
           if (u < x) a=u; else b=u;  
           if (fu <= fw || w == x) {  static double maxarg1,maxarg2;
             v=w;  #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))
             w=u;  #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))
             fv=fw;    
             fw=fu;  #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))
           } else if (fu <= fv || v == x || v == w) {  #define rint(a) floor(a+0.5)
             v=u;  
             fv=fu;  static double sqrarg;
           }  #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)
         }  #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;} 
   }  int agegomp= AGEGOMP;
   nrerror("Too many iterations in brent");  
   *xmin=x;  int imx; 
   return fx;  int stepm=1;
 }  /* Stepm, step in month: minimum step interpolation*/
   
 /****************** mnbrak ***********************/  int estepm;
   /* Estepm, step in month to interpolate survival function in order to approximate Life Expectancy*/
 void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc,  
             double (*func)(double))  int m,nb;
 {  long *num;
   double ulim,u,r,q, dum;  int firstpass=0, lastpass=4,*cod, *ncodemax, *Tage,*cens;
   double fu;  double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;
    double **pmmij, ***probs;
   *fa=(*func)(*ax);  double *ageexmed,*agecens;
   *fb=(*func)(*bx);  double dateintmean=0;
   if (*fb > *fa) {  
     SHFT(dum,*ax,*bx,dum)  double *weight;
       SHFT(dum,*fb,*fa,dum)  int **s; /* Status */
       }  double *agedc, **covar, idx;
   *cx=(*bx)+GOLD*(*bx-*ax);  int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;
   *fc=(*func)(*cx);  double *lsurv, *lpop, *tpop;
   while (*fb > *fc) {  
     r=(*bx-*ax)*(*fb-*fc);  double ftol=FTOL; /* Tolerance for computing Max Likelihood */
     q=(*bx-*cx)*(*fb-*fa);  double ftolhess; /* Tolerance for computing hessian */
     u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/  
       (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r));  /**************** split *************************/
     ulim=(*bx)+GLIMIT*(*cx-*bx);  static  int split( char *path, char *dirc, char *name, char *ext, char *finame )
     if ((*bx-u)*(u-*cx) > 0.0) {  {
       fu=(*func)(u);    /* From a file name with (full) path (either Unix or Windows) we extract the directory (dirc)
     } else if ((*cx-u)*(u-ulim) > 0.0) {       the name of the file (name), its extension only (ext) and its first part of the name (finame)
       fu=(*func)(u);    */ 
       if (fu < *fc) {    char  *ss;                            /* pointer */
         SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx))    int   l1, l2;                         /* length counters */
           SHFT(*fb,*fc,fu,(*func)(u))  
           }    l1 = strlen(path );                   /* length of path */
     } else if ((u-ulim)*(ulim-*cx) >= 0.0) {    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );
       u=ulim;    ss= strrchr( path, DIRSEPARATOR );            /* find last / */
       fu=(*func)(u);    if ( ss == NULL ) {                   /* no directory, so determine current directory */
     } else {      strcpy( name, path );               /* we got the fullname name because no directory */
       u=(*cx)+GOLD*(*cx-*bx);      /*if(strrchr(path, ODIRSEPARATOR )==NULL)
       fu=(*func)(u);        printf("Warning you should use %s as a separator\n",DIRSEPARATOR);*/
     }      /* get current working directory */
     SHFT(*ax,*bx,*cx,u)      /*    extern  char* getcwd ( char *buf , int len);*/
       SHFT(*fa,*fb,*fc,fu)      if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {
       }        return( GLOCK_ERROR_GETCWD );
 }      }
       /* got dirc from getcwd*/
 /*************** linmin ************************/      printf(" DIRC = %s \n",dirc);
     } else {                              /* strip direcotry from path */
 int ncom;      ss++;                               /* after this, the filename */
 double *pcom,*xicom;      l2 = strlen( ss );                  /* length of filename */
 double (*nrfunc)(double []);      if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );
        strcpy( name, ss );         /* save file name */
 void linmin(double p[], double xi[], int n, double *fret,double (*func)(double []))      strncpy( dirc, path, l1 - l2 );     /* now the directory */
 {      dirc[l1-l2] = 0;                    /* add zero */
   double brent(double ax, double bx, double cx,      printf(" DIRC2 = %s \n",dirc);
                double (*f)(double), double tol, double *xmin);    }
   double f1dim(double x);    /* We add a separator at the end of dirc if not exists */
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb,    l1 = strlen( dirc );                  /* length of directory */
               double *fc, double (*func)(double));    if( dirc[l1-1] != DIRSEPARATOR ){
   int j;      dirc[l1] =  DIRSEPARATOR;
   double xx,xmin,bx,ax;      dirc[l1+1] = 0; 
   double fx,fb,fa;      printf(" DIRC3 = %s \n",dirc);
      }
   ncom=n;    ss = strrchr( name, '.' );            /* find last / */
   pcom=vector(1,n);    if (ss >0){
   xicom=vector(1,n);      ss++;
   nrfunc=func;      strcpy(ext,ss);                     /* save extension */
   for (j=1;j<=n;j++) {      l1= strlen( name);
     pcom[j]=p[j];      l2= strlen(ss)+1;
     xicom[j]=xi[j];      strncpy( finame, name, l1-l2);
   }      finame[l1-l2]= 0;
   ax=0.0;    }
   xx=1.0;  
   mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim);    return( 0 );                          /* we're done */
   *fret=brent(ax,xx,bx,f1dim,TOL,&xmin);  }
 #ifdef DEBUG  
   printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);  
 #endif  /******************************************/
   for (j=1;j<=n;j++) {  
     xi[j] *= xmin;  void replace_back_to_slash(char *s, char*t)
     p[j] += xi[j];  {
   }    int i;
   free_vector(xicom,1,n);    int lg=0;
   free_vector(pcom,1,n);    i=0;
 }    lg=strlen(t);
     for(i=0; i<= lg; i++) {
 /*************** powell ************************/      (s[i] = t[i]);
 void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret,      if (t[i]== '\\') s[i]='/';
             double (*func)(double []))    }
 {  }
   void linmin(double p[], double xi[], int n, double *fret,  
               double (*func)(double []));  int nbocc(char *s, char occ)
   int i,ibig,j;  {
   double del,t,*pt,*ptt,*xit;    int i,j=0;
   double fp,fptt;    int lg=20;
   double *xits;    i=0;
   pt=vector(1,n);    lg=strlen(s);
   ptt=vector(1,n);    for(i=0; i<= lg; i++) {
   xit=vector(1,n);    if  (s[i] == occ ) j++;
   xits=vector(1,n);    }
   *fret=(*func)(p);    return j;
   for (j=1;j<=n;j++) pt[j]=p[j];  }
   for (*iter=1;;++(*iter)) {  
     fp=(*fret);  void cutv(char *u,char *v, char*t, char occ)
     ibig=0;  {
     del=0.0;    /* cuts string t into u and v where u ends before first occurence of char 'occ' 
     printf("\nPowell iter=%d -2*LL=%.12f",*iter,*fret);       and v starts after first occurence of char 'occ' : ex cutv(u,v,"abcdef2ghi2j",'2')
     for (i=1;i<=n;i++)       gives u="abcedf" and v="ghi2j" */
       printf(" %d %.12f",i, p[i]);    int i,lg,j,p=0;
     printf("\n");    i=0;
     for (i=1;i<=n;i++) {    for(j=0; j<=strlen(t)-1; j++) {
       for (j=1;j<=n;j++) xit[j]=xi[j][i];      if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;
       fptt=(*fret);    }
 #ifdef DEBUG  
       printf("fret=%lf \n",*fret);    lg=strlen(t);
 #endif    for(j=0; j<p; j++) {
       printf("%d",i);fflush(stdout);      (u[j] = t[j]);
       linmin(p,xit,n,fret,func);    }
       if (fabs(fptt-(*fret)) > del) {       u[p]='\0';
         del=fabs(fptt-(*fret));  
         ibig=i;     for(j=0; j<= lg; j++) {
       }      if (j>=(p+1))(v[j-p-1] = t[j]);
 #ifdef DEBUG    }
       printf("%d %.12e",i,(*fret));  }
       for (j=1;j<=n;j++) {  
         xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);  /********************** nrerror ********************/
         printf(" x(%d)=%.12e",j,xit[j]);  
       }  void nrerror(char error_text[])
       for(j=1;j<=n;j++)  {
         printf(" p=%.12e",p[j]);    fprintf(stderr,"ERREUR ...\n");
       printf("\n");    fprintf(stderr,"%s\n",error_text);
 #endif    exit(EXIT_FAILURE);
     }  }
     if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {  /*********************** vector *******************/
 #ifdef DEBUG  double *vector(int nl, int nh)
       int k[2],l;  {
       k[0]=1;    double *v;
       k[1]=-1;    v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));
       printf("Max: %.12e",(*func)(p));    if (!v) nrerror("allocation failure in vector");
       for (j=1;j<=n;j++)    return v-nl+NR_END;
         printf(" %.12e",p[j]);  }
       printf("\n");  
       for(l=0;l<=1;l++) {  /************************ free vector ******************/
         for (j=1;j<=n;j++) {  void free_vector(double*v, int nl, int nh)
           ptt[j]=p[j]+(p[j]-pt[j])*k[l];  {
           printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);    free((FREE_ARG)(v+nl-NR_END));
         }  }
         printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));  
       }  /************************ivector *******************************/
 #endif  int *ivector(long nl,long nh)
   {
     int *v;
       free_vector(xit,1,n);    v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));
       free_vector(xits,1,n);    if (!v) nrerror("allocation failure in ivector");
       free_vector(ptt,1,n);    return v-nl+NR_END;
       free_vector(pt,1,n);  }
       return;  
     }  /******************free ivector **************************/
     if (*iter == ITMAX) nrerror("powell exceeding maximum iterations.");  void free_ivector(int *v, long nl, long nh)
     for (j=1;j<=n;j++) {  {
       ptt[j]=2.0*p[j]-pt[j];    free((FREE_ARG)(v+nl-NR_END));
       xit[j]=p[j]-pt[j];  }
       pt[j]=p[j];  
     }  /************************lvector *******************************/
     fptt=(*func)(ptt);  long *lvector(long nl,long nh)
     if (fptt < fp) {  {
       t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt);    long *v;
       if (t < 0.0) {    v=(long *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(long)));
         linmin(p,xit,n,fret,func);    if (!v) nrerror("allocation failure in ivector");
         for (j=1;j<=n;j++) {    return v-nl+NR_END;
           xi[j][ibig]=xi[j][n];  }
           xi[j][n]=xit[j];  
         }  /******************free lvector **************************/
 #ifdef DEBUG  void free_lvector(long *v, long nl, long nh)
         printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);  {
         for(j=1;j<=n;j++)    free((FREE_ARG)(v+nl-NR_END));
           printf(" %.12e",xit[j]);  }
         printf("\n");  
 #endif  /******************* imatrix *******************************/
       }  int **imatrix(long nrl, long nrh, long ncl, long nch) 
     }       /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */ 
   }  { 
 }    long i, nrow=nrh-nrl+1,ncol=nch-ncl+1; 
     int **m; 
 /**** Prevalence limit ****************/    
     /* allocate pointers to rows */ 
 double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)    m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*))); 
 {    if (!m) nrerror("allocation failure 1 in matrix()"); 
   /* Computes the prevalence limit in each live state at age x by left multiplying the unit    m += NR_END; 
      matrix by transitions matrix until convergence is reached */    m -= nrl; 
     
   int i, ii,j,k;    
   double min, max, maxmin, maxmax,sumnew=0.;    /* allocate rows and set pointers to them */ 
   double **matprod2();    m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int))); 
   double **out, cov[NCOVMAX], **pmij();    if (!m[nrl]) nrerror("allocation failure 2 in matrix()"); 
   double **newm;    m[nrl] += NR_END; 
   double agefin, delaymax=50 ; /* Max number of years to converge */    m[nrl] -= ncl; 
     
   for (ii=1;ii<=nlstate+ndeath;ii++)    for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol; 
     for (j=1;j<=nlstate+ndeath;j++){    
       oldm[ii][j]=(ii==j ? 1.0 : 0.0);    /* return pointer to array of pointers to rows */ 
     }    return m; 
   } 
    cov[1]=1.;  
    /****************** free_imatrix *************************/
  /* Even if hstepm = 1, at least one multiplication by the unit matrix */  void free_imatrix(m,nrl,nrh,ncl,nch)
   for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){        int **m;
     newm=savm;        long nch,ncl,nrh,nrl; 
     /* Covariates have to be included here again */       /* free an int matrix allocated by imatrix() */ 
      cov[2]=agefin;  { 
      free((FREE_ARG) (m[nrl]+ncl-NR_END)); 
       for (k=1; k<=cptcovn;k++) {    free((FREE_ARG) (m+nrl-NR_END)); 
         cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];  } 
         /*printf("ij=%d Tvar[k]=%d nbcode=%d cov=%lf\n",ij, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k]);*/  
       }  /******************* matrix *******************************/
       for (k=1; k<=cptcovage;k++)  double **matrix(long nrl, long nrh, long ncl, long nch)
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];  {
       for (k=1; k<=cptcovprod;k++)    long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];    double **m;
   
       /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/    m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
       /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/    if (!m) nrerror("allocation failure 1 in matrix()");
     m += NR_END;
     out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);    m -= nrl;
   
     savm=oldm;    m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
     oldm=newm;    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
     maxmax=0.;    m[nrl] += NR_END;
     for(j=1;j<=nlstate;j++){    m[nrl] -= ncl;
       min=1.;  
       max=0.;    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
       for(i=1; i<=nlstate; i++) {    return m;
         sumnew=0;    /* print *(*(m+1)+70) or print m[1][70]; print m+1 or print &(m[1]) 
         for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];     */
         prlim[i][j]= newm[i][j]/(1-sumnew);  }
         max=FMAX(max,prlim[i][j]);  
         min=FMIN(min,prlim[i][j]);  /*************************free matrix ************************/
       }  void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)
       maxmin=max-min;  {
       maxmax=FMAX(maxmax,maxmin);    free((FREE_ARG)(m[nrl]+ncl-NR_END));
     }    free((FREE_ARG)(m+nrl-NR_END));
     if(maxmax < ftolpl){  }
       return prlim;  
     }  /******************* ma3x *******************************/
   }  double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)
 }  {
     long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;
 /*************** transition probabilities **********/    double ***m;
   
 double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )    m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
 {    if (!m) nrerror("allocation failure 1 in matrix()");
   double s1, s2;    m += NR_END;
   /*double t34;*/    m -= nrl;
   int i,j,j1, nc, ii, jj;  
     m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
     for(i=1; i<= nlstate; i++){    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
     for(j=1; j<i;j++){    m[nrl] += NR_END;
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){    m[nrl] -= ncl;
         /*s2 += param[i][j][nc]*cov[nc];*/  
         s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
         /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/  
       }    m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));
       ps[i][j]=s2;    if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");
       /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/    m[nrl][ncl] += NR_END;
     }    m[nrl][ncl] -= nll;
     for(j=i+1; j<=nlstate+ndeath;j++){    for (j=ncl+1; j<=nch; j++) 
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){      m[nrl][j]=m[nrl][j-1]+nlay;
         s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    
         /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/    for (i=nrl+1; i<=nrh; i++) {
       }      m[i][ncl]=m[i-1l][ncl]+ncol*nlay;
       ps[i][j]=s2;      for (j=ncl+1; j<=nch; j++) 
     }        m[i][j]=m[i][j-1]+nlay;
   }    }
   for(i=1; i<= nlstate; i++){    return m; 
      s1=0;    /*  gdb: p *(m+1) <=> p m[1] and p (m+1) <=> p (m+1) <=> p &(m[1])
     for(j=1; j<i; j++)             &(m[i][j][k]) <=> *((*(m+i) + j)+k)
       s1+=exp(ps[i][j]);    */
     for(j=i+1; j<=nlstate+ndeath; j++)  }
       s1+=exp(ps[i][j]);  
     ps[i][i]=1./(s1+1.);  /*************************free ma3x ************************/
     for(j=1; j<i; j++)  void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)
       ps[i][j]= exp(ps[i][j])*ps[i][i];  {
     for(j=i+1; j<=nlstate+ndeath; j++)    free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));
       ps[i][j]= exp(ps[i][j])*ps[i][i];    free((FREE_ARG)(m[nrl]+ncl-NR_END));
     /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */    free((FREE_ARG)(m+nrl-NR_END));
   } /* end i */  }
   
   for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){  /*************** function subdirf ***********/
     for(jj=1; jj<= nlstate+ndeath; jj++){  char *subdirf(char fileres[])
       ps[ii][jj]=0;  {
       ps[ii][ii]=1;    /* Caution optionfilefiname is hidden */
     }    strcpy(tmpout,optionfilefiname);
   }    strcat(tmpout,"/"); /* Add to the right */
     strcat(tmpout,fileres);
   /*   for(ii=1; ii<= nlstate+ndeath; ii++){    return tmpout;
     for(jj=1; jj<= nlstate+ndeath; jj++){  }
      printf("%lf ",ps[ii][jj]);  
    }  /*************** function subdirf2 ***********/
     printf("\n ");  char *subdirf2(char fileres[], char *preop)
     }  {
     printf("\n ");printf("%lf ",cov[2]);*/    
 /*    /* Caution optionfilefiname is hidden */
   for(i=1; i<= npar; i++) printf("%f ",x[i]);    strcpy(tmpout,optionfilefiname);
   goto end;*/    strcat(tmpout,"/");
     return ps;    strcat(tmpout,preop);
 }    strcat(tmpout,fileres);
     return tmpout;
 /**************** Product of 2 matrices ******************/  }
   
 double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)  /*************** function subdirf3 ***********/
 {  char *subdirf3(char fileres[], char *preop, char *preop2)
   /* Computes the matric product of in(1,nrh-nrl+1)(1,nch-ncl+1) times  {
      b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */    
   /* in, b, out are matrice of pointers which should have been initialized    /* Caution optionfilefiname is hidden */
      before: only the contents of out is modified. The function returns    strcpy(tmpout,optionfilefiname);
      a pointer to pointers identical to out */    strcat(tmpout,"/");
   long i, j, k;    strcat(tmpout,preop);
   for(i=nrl; i<= nrh; i++)    strcat(tmpout,preop2);
     for(k=ncolol; k<=ncoloh; k++)    strcat(tmpout,fileres);
       for(j=ncl,out[i][k]=0.; j<=nch; j++)    return tmpout;
         out[i][k] +=in[i][j]*b[j][k];  }
   
   return out;  /***************** f1dim *************************/
 }  extern int ncom; 
   extern double *pcom,*xicom;
   extern double (*nrfunc)(double []); 
 /************* Higher Matrix Product ***************/   
   double f1dim(double x) 
 double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )  { 
 {    int j; 
   /* Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' month    double f;
      duration (i.e. until    double *xt; 
      age (in years)  age+nhstepm*stepm/12) by multiplying nhstepm*hstepm matrices.   
      Output is stored in matrix po[i][j][h] for h every 'hstepm' step    xt=vector(1,ncom); 
      (typically every 2 years instead of every month which is too big).    for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j]; 
      Model is determined by parameters x and covariates have to be    f=(*nrfunc)(xt); 
      included manually here.    free_vector(xt,1,ncom); 
     return f; 
      */  } 
   
   int i, j, d, h, k;  /*****************brent *************************/
   double **out, cov[NCOVMAX];  double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin) 
   double **newm;  { 
     int iter; 
   /* Hstepm could be zero and should return the unit matrix */    double a,b,d,etemp;
   for (i=1;i<=nlstate+ndeath;i++)    double fu,fv,fw,fx;
     for (j=1;j<=nlstate+ndeath;j++){    double ftemp;
       oldm[i][j]=(i==j ? 1.0 : 0.0);    double p,q,r,tol1,tol2,u,v,w,x,xm; 
       po[i][j][0]=(i==j ? 1.0 : 0.0);    double e=0.0; 
     }   
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */    a=(ax < cx ? ax : cx); 
   for(h=1; h <=nhstepm; h++){    b=(ax > cx ? ax : cx); 
     for(d=1; d <=hstepm; d++){    x=w=v=bx; 
       newm=savm;    fw=fv=fx=(*f)(x); 
       /* Covariates have to be included here again */    for (iter=1;iter<=ITMAX;iter++) { 
       cov[1]=1.;      xm=0.5*(a+b); 
       cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;      tol2=2.0*(tol1=tol*fabs(x)+ZEPS); 
       for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];      /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/
 for (k=1; k<=cptcovage;k++)      printf(".");fflush(stdout);
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];      fprintf(ficlog,".");fflush(ficlog);
    for (k=1; k<=cptcovprod;k++)  #ifdef DEBUG
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];      printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
       fprintf(ficlog,"br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
       /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */
       /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/  #endif
       /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/      if (fabs(x-xm) <= (tol2-0.5*(b-a))){ 
       out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath,        *xmin=x; 
                    pmij(pmmij,cov,ncovmodel,x,nlstate));        return fx; 
       savm=oldm;      } 
       oldm=newm;      ftemp=fu;
     }      if (fabs(e) > tol1) { 
     for(i=1; i<=nlstate+ndeath; i++)        r=(x-w)*(fx-fv); 
       for(j=1;j<=nlstate+ndeath;j++) {        q=(x-v)*(fx-fw); 
         po[i][j][h]=newm[i][j];        p=(x-v)*q-(x-w)*r; 
         /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);        q=2.0*(q-r); 
          */        if (q > 0.0) p = -p; 
       }        q=fabs(q); 
   } /* end h */        etemp=e; 
   return po;        e=d; 
 }        if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x)) 
           d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
         else { 
 /*************** log-likelihood *************/          d=p/q; 
 double func( double *x)          u=x+d; 
 {          if (u-a < tol2 || b-u < tol2) 
   int i, ii, j, k, mi, d, kk;            d=SIGN(tol1,xm-x); 
   double l, ll[NLSTATEMAX], cov[NCOVMAX];        } 
   double **out;      } else { 
   double sw; /* Sum of weights */        d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
   double lli; /* Individual log likelihood */      } 
   long ipmx;      u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d)); 
   /*extern weight */      fu=(*f)(u); 
   /* We are differentiating ll according to initial status */      if (fu <= fx) { 
   /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/        if (u >= x) a=x; else b=x; 
   /*for(i=1;i<imx;i++)        SHFT(v,w,x,u) 
     printf(" %d\n",s[4][i]);          SHFT(fv,fw,fx,fu) 
   */          } else { 
   cov[1]=1.;            if (u < x) a=u; else b=u; 
             if (fu <= fw || w == x) { 
   for(k=1; k<=nlstate; k++) ll[k]=0.;              v=w; 
   for (i=1,ipmx=0, sw=0.; i<=imx; i++){              w=u; 
     for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];              fv=fw; 
     for(mi=1; mi<= wav[i]-1; mi++){              fw=fu; 
       for (ii=1;ii<=nlstate+ndeath;ii++)            } else if (fu <= fv || v == x || v == w) { 
         for (j=1;j<=nlstate+ndeath;j++) oldm[ii][j]=(ii==j ? 1.0 : 0.0);              v=u; 
       for(d=0; d<dh[mi][i]; d++){              fv=fu; 
         newm=savm;            } 
         cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;          } 
         for (kk=1; kk<=cptcovage;kk++) {    } 
           cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];    nrerror("Too many iterations in brent"); 
         }    *xmin=x; 
            return fx; 
         out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,  } 
                      1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));  
         savm=oldm;  /****************** mnbrak ***********************/
         oldm=newm;  
          void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc, 
                      double (*func)(double)) 
       } /* end mult */  { 
          double ulim,u,r,q, dum;
       lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);    double fu; 
       /* printf(" %f ",out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/   
       ipmx +=1;    *fa=(*func)(*ax); 
       sw += weight[i];    *fb=(*func)(*bx); 
       ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;    if (*fb > *fa) { 
     } /* end of wave */      SHFT(dum,*ax,*bx,dum) 
   } /* end of individual */        SHFT(dum,*fb,*fa,dum) 
         } 
   for(k=1,l=0.; k<=nlstate; k++) l += ll[k];    *cx=(*bx)+GOLD*(*bx-*ax); 
   /* printf("l1=%f l2=%f ",ll[1],ll[2]); */    *fc=(*func)(*cx); 
   l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */    while (*fb > *fc) { 
   return -l;      r=(*bx-*ax)*(*fb-*fc); 
 }      q=(*bx-*cx)*(*fb-*fa); 
       u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/ 
         (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r)); 
 /*********** Maximum Likelihood Estimation ***************/      ulim=(*bx)+GLIMIT*(*cx-*bx); 
       if ((*bx-u)*(u-*cx) > 0.0) { 
 void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))        fu=(*func)(u); 
 {      } else if ((*cx-u)*(u-ulim) > 0.0) { 
   int i,j, iter;        fu=(*func)(u); 
   double **xi,*delti;        if (fu < *fc) { 
   double fret;          SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx)) 
   xi=matrix(1,npar,1,npar);            SHFT(*fb,*fc,fu,(*func)(u)) 
   for (i=1;i<=npar;i++)            } 
     for (j=1;j<=npar;j++)      } else if ((u-ulim)*(ulim-*cx) >= 0.0) { 
       xi[i][j]=(i==j ? 1.0 : 0.0);        u=ulim; 
   printf("Powell\n");        fu=(*func)(u); 
   powell(p,xi,npar,ftol,&iter,&fret,func);      } else { 
         u=(*cx)+GOLD*(*cx-*bx); 
    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));        fu=(*func)(u); 
   fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f ",iter,func(p));      } 
       SHFT(*ax,*bx,*cx,u) 
 }        SHFT(*fa,*fb,*fc,fu) 
         } 
 /**** Computes Hessian and covariance matrix ***/  } 
 void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))  
 {  /*************** linmin ************************/
   double  **a,**y,*x,pd;  
   double **hess;  int ncom; 
   int i, j,jk;  double *pcom,*xicom;
   int *indx;  double (*nrfunc)(double []); 
    
   double hessii(double p[], double delta, int theta, double delti[]);  void linmin(double p[], double xi[], int n, double *fret,double (*func)(double [])) 
   double hessij(double p[], double delti[], int i, int j);  { 
   void lubksb(double **a, int npar, int *indx, double b[]) ;    double brent(double ax, double bx, double cx, 
   void ludcmp(double **a, int npar, int *indx, double *d) ;                 double (*f)(double), double tol, double *xmin); 
     double f1dim(double x); 
     void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, 
   hess=matrix(1,npar,1,npar);                double *fc, double (*func)(double)); 
     int j; 
   printf("\nCalculation of the hessian matrix. Wait...\n");    double xx,xmin,bx,ax; 
   for (i=1;i<=npar;i++){    double fx,fb,fa;
     printf("%d",i);fflush(stdout);   
     hess[i][i]=hessii(p,ftolhess,i,delti);    ncom=n; 
     /*printf(" %f ",p[i]);*/    pcom=vector(1,n); 
   }    xicom=vector(1,n); 
     nrfunc=func; 
   for (i=1;i<=npar;i++) {    for (j=1;j<=n;j++) { 
     for (j=1;j<=npar;j++)  {      pcom[j]=p[j]; 
       if (j>i) {      xicom[j]=xi[j]; 
         printf(".%d%d",i,j);fflush(stdout);    } 
         hess[i][j]=hessij(p,delti,i,j);    ax=0.0; 
         hess[j][i]=hess[i][j];    xx=1.0; 
       }    mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim); 
     }    *fret=brent(ax,xx,bx,f1dim,TOL,&xmin); 
   }  #ifdef DEBUG
   printf("\n");    printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
     fprintf(ficlog,"retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
   printf("\nInverting the hessian to get the covariance matrix. Wait...\n");  #endif
      for (j=1;j<=n;j++) { 
   a=matrix(1,npar,1,npar);      xi[j] *= xmin; 
   y=matrix(1,npar,1,npar);      p[j] += xi[j]; 
   x=vector(1,npar);    } 
   indx=ivector(1,npar);    free_vector(xicom,1,n); 
   for (i=1;i<=npar;i++)    free_vector(pcom,1,n); 
     for (j=1;j<=npar;j++) a[i][j]=hess[i][j];  } 
   ludcmp(a,npar,indx,&pd);  
   char *asc_diff_time(long time_sec, char ascdiff[])
   for (j=1;j<=npar;j++) {  {
     for (i=1;i<=npar;i++) x[i]=0;    long sec_left, days, hours, minutes;
     x[j]=1;    days = (time_sec) / (60*60*24);
     lubksb(a,npar,indx,x);    sec_left = (time_sec) % (60*60*24);
     for (i=1;i<=npar;i++){    hours = (sec_left) / (60*60) ;
       matcov[i][j]=x[i];    sec_left = (sec_left) %(60*60);
     }    minutes = (sec_left) /60;
   }    sec_left = (sec_left) % (60);
     sprintf(ascdiff,"%d day(s) %d hour(s) %d minute(s) %d second(s)",days, hours, minutes, sec_left);  
   printf("\n#Hessian matrix#\n");    return ascdiff;
   for (i=1;i<=npar;i++) {  }
     for (j=1;j<=npar;j++) {  
       printf("%.3e ",hess[i][j]);  /*************** powell ************************/
     }  void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret, 
     printf("\n");              double (*func)(double [])) 
   }  { 
     void linmin(double p[], double xi[], int n, double *fret, 
   /* Recompute Inverse */                double (*func)(double [])); 
   for (i=1;i<=npar;i++)    int i,ibig,j; 
     for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];    double del,t,*pt,*ptt,*xit;
   ludcmp(a,npar,indx,&pd);    double fp,fptt;
     double *xits;
   /*  printf("\n#Hessian matrix recomputed#\n");    int niterf, itmp;
   
   for (j=1;j<=npar;j++) {    pt=vector(1,n); 
     for (i=1;i<=npar;i++) x[i]=0;    ptt=vector(1,n); 
     x[j]=1;    xit=vector(1,n); 
     lubksb(a,npar,indx,x);    xits=vector(1,n); 
     for (i=1;i<=npar;i++){    *fret=(*func)(p); 
       y[i][j]=x[i];    for (j=1;j<=n;j++) pt[j]=p[j]; 
       printf("%.3e ",y[i][j]);    for (*iter=1;;++(*iter)) { 
     }      fp=(*fret); 
     printf("\n");      ibig=0; 
   }      del=0.0; 
   */      last_time=curr_time;
       (void) gettimeofday(&curr_time,&tzp);
   free_matrix(a,1,npar,1,npar);      printf("\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);fflush(stdout);
   free_matrix(y,1,npar,1,npar);      /*    fprintf(ficlog,"\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);
   free_vector(x,1,npar);      fprintf(ficrespow,"%d %.12f %ld",*iter,*fret,curr_time.tv_sec-start_time.tv_sec);
   free_ivector(indx,1,npar);      */
   free_matrix(hess,1,npar,1,npar);     for (i=1;i<=n;i++) {
         printf(" %d %.12f",i, p[i]);
         fprintf(ficlog," %d %.12lf",i, p[i]);
 }        fprintf(ficrespow," %.12lf", p[i]);
       }
 /*************** hessian matrix ****************/      printf("\n");
 double hessii( double x[], double delta, int theta, double delti[])      fprintf(ficlog,"\n");
 {      fprintf(ficrespow,"\n");fflush(ficrespow);
   int i;      if(*iter <=3){
   int l=1, lmax=20;        tm = *localtime(&curr_time.tv_sec);
   double k1,k2;        strcpy(strcurr,asctime(&tm));
   double p2[NPARMAX+1];  /*       asctime_r(&tm,strcurr); */
   double res;        forecast_time=curr_time; 
   double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;        itmp = strlen(strcurr);
   double fx;        if(strcurr[itmp-1]=='\n')  /* Windows outputs with a new line */
   int k=0,kmax=10;          strcurr[itmp-1]='\0';
   double l1;        printf("\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
         fprintf(ficlog,"\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
   fx=func(x);        for(niterf=10;niterf<=30;niterf+=10){
   for (i=1;i<=npar;i++) p2[i]=x[i];          forecast_time.tv_sec=curr_time.tv_sec+(niterf-*iter)*(curr_time.tv_sec-last_time.tv_sec);
   for(l=0 ; l <=lmax; l++){          tmf = *localtime(&forecast_time.tv_sec);
     l1=pow(10,l);  /*      asctime_r(&tmf,strfor); */
     delts=delt;          strcpy(strfor,asctime(&tmf));
     for(k=1 ; k <kmax; k=k+1){          itmp = strlen(strfor);
       delt = delta*(l1*k);          if(strfor[itmp-1]=='\n')
       p2[theta]=x[theta] +delt;          strfor[itmp-1]='\0';
       k1=func(p2)-fx;          printf("   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
       p2[theta]=x[theta]-delt;          fprintf(ficlog,"   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
       k2=func(p2)-fx;        }
       /*res= (k1-2.0*fx+k2)/delt/delt; */      }
       res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */      for (i=1;i<=n;i++) { 
              for (j=1;j<=n;j++) xit[j]=xi[j][i]; 
 #ifdef DEBUG        fptt=(*fret); 
       printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);  #ifdef DEBUG
 #endif        printf("fret=%lf \n",*fret);
       /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */        fprintf(ficlog,"fret=%lf \n",*fret);
       if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){  #endif
         k=kmax;        printf("%d",i);fflush(stdout);
       }        fprintf(ficlog,"%d",i);fflush(ficlog);
       else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */        linmin(p,xit,n,fret,func); 
         k=kmax; l=lmax*10.;        if (fabs(fptt-(*fret)) > del) { 
       }          del=fabs(fptt-(*fret)); 
       else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){          ibig=i; 
         delts=delt;        } 
       }  #ifdef DEBUG
     }        printf("%d %.12e",i,(*fret));
   }        fprintf(ficlog,"%d %.12e",i,(*fret));
   delti[theta]=delts;        for (j=1;j<=n;j++) {
   return res;          xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);
            printf(" x(%d)=%.12e",j,xit[j]);
 }          fprintf(ficlog," x(%d)=%.12e",j,xit[j]);
         }
 double hessij( double x[], double delti[], int thetai,int thetaj)        for(j=1;j<=n;j++) {
 {          printf(" p=%.12e",p[j]);
   int i;          fprintf(ficlog," p=%.12e",p[j]);
   int l=1, l1, lmax=20;        }
   double k1,k2,k3,k4,res,fx;        printf("\n");
   double p2[NPARMAX+1];        fprintf(ficlog,"\n");
   int k;  #endif
       } 
   fx=func(x);      if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {
   for (k=1; k<=2; k++) {  #ifdef DEBUG
     for (i=1;i<=npar;i++) p2[i]=x[i];        int k[2],l;
     p2[thetai]=x[thetai]+delti[thetai]/k;        k[0]=1;
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;        k[1]=-1;
     k1=func(p2)-fx;        printf("Max: %.12e",(*func)(p));
          fprintf(ficlog,"Max: %.12e",(*func)(p));
     p2[thetai]=x[thetai]+delti[thetai]/k;        for (j=1;j<=n;j++) {
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;          printf(" %.12e",p[j]);
     k2=func(p2)-fx;          fprintf(ficlog," %.12e",p[j]);
          }
     p2[thetai]=x[thetai]-delti[thetai]/k;        printf("\n");
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;        fprintf(ficlog,"\n");
     k3=func(p2)-fx;        for(l=0;l<=1;l++) {
            for (j=1;j<=n;j++) {
     p2[thetai]=x[thetai]-delti[thetai]/k;            ptt[j]=p[j]+(p[j]-pt[j])*k[l];
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;            printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
     k4=func(p2)-fx;            fprintf(ficlog,"l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
     res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */          }
 #ifdef DEBUG          printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
     printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);          fprintf(ficlog,"func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
 #endif        }
   }  #endif
   return res;  
 }  
         free_vector(xit,1,n); 
 /************** Inverse of matrix **************/        free_vector(xits,1,n); 
 void ludcmp(double **a, int n, int *indx, double *d)        free_vector(ptt,1,n); 
 {        free_vector(pt,1,n); 
   int i,imax,j,k;        return; 
   double big,dum,sum,temp;      } 
   double *vv;      if (*iter == ITMAX) nrerror("powell exceeding maximum iterations."); 
        for (j=1;j<=n;j++) { 
   vv=vector(1,n);        ptt[j]=2.0*p[j]-pt[j]; 
   *d=1.0;        xit[j]=p[j]-pt[j]; 
   for (i=1;i<=n;i++) {        pt[j]=p[j]; 
     big=0.0;      } 
     for (j=1;j<=n;j++)      fptt=(*func)(ptt); 
       if ((temp=fabs(a[i][j])) > big) big=temp;      if (fptt < fp) { 
     if (big == 0.0) nrerror("Singular matrix in routine ludcmp");        t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt); 
     vv[i]=1.0/big;        if (t < 0.0) { 
   }          linmin(p,xit,n,fret,func); 
   for (j=1;j<=n;j++) {          for (j=1;j<=n;j++) { 
     for (i=1;i<j;i++) {            xi[j][ibig]=xi[j][n]; 
       sum=a[i][j];            xi[j][n]=xit[j]; 
       for (k=1;k<i;k++) sum -= a[i][k]*a[k][j];          }
       a[i][j]=sum;  #ifdef DEBUG
     }          printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
     big=0.0;          fprintf(ficlog,"Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
     for (i=j;i<=n;i++) {          for(j=1;j<=n;j++){
       sum=a[i][j];            printf(" %.12e",xit[j]);
       for (k=1;k<j;k++)            fprintf(ficlog," %.12e",xit[j]);
         sum -= a[i][k]*a[k][j];          }
       a[i][j]=sum;          printf("\n");
       if ( (dum=vv[i]*fabs(sum)) >= big) {          fprintf(ficlog,"\n");
         big=dum;  #endif
         imax=i;        }
       }      } 
     }    } 
     if (j != imax) {  } 
       for (k=1;k<=n;k++) {  
         dum=a[imax][k];  /**** Prevalence limit (stable or period prevalence)  ****************/
         a[imax][k]=a[j][k];  
         a[j][k]=dum;  double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)
       }  {
       *d = -(*d);    /* Computes the prevalence limit in each live state at age x by left multiplying the unit
       vv[imax]=vv[j];       matrix by transitions matrix until convergence is reached */
     }  
     indx[j]=imax;    int i, ii,j,k;
     if (a[j][j] == 0.0) a[j][j]=TINY;    double min, max, maxmin, maxmax,sumnew=0.;
     if (j != n) {    double **matprod2();
       dum=1.0/(a[j][j]);    double **out, cov[NCOVMAX], **pmij();
       for (i=j+1;i<=n;i++) a[i][j] *= dum;    double **newm;
     }    double agefin, delaymax=50 ; /* Max number of years to converge */
   }  
   free_vector(vv,1,n);  /* Doesn't work */    for (ii=1;ii<=nlstate+ndeath;ii++)
 ;      for (j=1;j<=nlstate+ndeath;j++){
 }        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       }
 void lubksb(double **a, int n, int *indx, double b[])  
 {     cov[1]=1.;
   int i,ii=0,ip,j;   
   double sum;   /* Even if hstepm = 1, at least one multiplication by the unit matrix */
      for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){
   for (i=1;i<=n;i++) {      newm=savm;
     ip=indx[i];      /* Covariates have to be included here again */
     sum=b[ip];       cov[2]=agefin;
     b[ip]=b[i];    
     if (ii)        for (k=1; k<=cptcovn;k++) {
       for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j];          cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
     else if (sum) ii=i;          /*      printf("ij=%d k=%d Tvar[k]=%d nbcode=%d cov=%lf codtab[ij][Tvar[k]]=%d \n",ij,k, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k], codtab[ij][Tvar[k]]);*/
     b[i]=sum;        }
   }        for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
   for (i=n;i>=1;i--) {        for (k=1; k<=cptcovprod;k++)
     sum=b[i];          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
     for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j];  
     b[i]=sum/a[i][i];        /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/
   }        /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/
 }        /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/
       out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);
 /************ Frequencies ********************/  
 void  freqsummary(char fileres[], int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax)      savm=oldm;
 {  /* Some frequencies */      oldm=newm;
        maxmax=0.;
   int i, m, jk, k1, i1, j1, bool, z1,z2,j;      for(j=1;j<=nlstate;j++){
   double ***freq; /* Frequencies */        min=1.;
   double *pp;        max=0.;
   double pos;        for(i=1; i<=nlstate; i++) {
   FILE *ficresp;          sumnew=0;
   char fileresp[FILENAMELENGTH];          for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];
           prlim[i][j]= newm[i][j]/(1-sumnew);
   pp=vector(1,nlstate);          max=FMAX(max,prlim[i][j]);
           min=FMIN(min,prlim[i][j]);
   strcpy(fileresp,"p");        }
   strcat(fileresp,fileres);        maxmin=max-min;
   if((ficresp=fopen(fileresp,"w"))==NULL) {        maxmax=FMAX(maxmax,maxmin);
     printf("Problem with prevalence resultfile: %s\n", fileresp);      }
     exit(0);      if(maxmax < ftolpl){
   }        return prlim;
   freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);      }
   j1=0;    }
   }
   j=cptcoveff;  
   if (cptcovn<1) {j=1;ncodemax[1]=1;}  /*************** transition probabilities ***************/ 
   
   for(k1=1; k1<=j;k1++){  double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )
    for(i1=1; i1<=ncodemax[k1];i1++){  {
        j1++;    double s1, s2;
        /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);    /*double t34;*/
          scanf("%d", i);*/    int i,j,j1, nc, ii, jj;
         for (i=-1; i<=nlstate+ndeath; i++)    
          for (jk=-1; jk<=nlstate+ndeath; jk++)        for(i=1; i<= nlstate; i++){
            for(m=agemin; m <= agemax+3; m++)        for(j=1; j<i;j++){
              freq[i][jk][m]=0;          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
                    /*s2 += param[i][j][nc]*cov[nc];*/
        for (i=1; i<=imx; i++) {            s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
          bool=1;  /*       printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2); */
          if  (cptcovn>0) {          }
            for (z1=1; z1<=cptcoveff; z1++)          ps[i][j]=s2;
              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]])  /*      printf("s1=%.17e, s2=%.17e\n",s1,s2); */
                bool=0;        }
          }        for(j=i+1; j<=nlstate+ndeath;j++){
           if (bool==1) {          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
            for(m=firstpass; m<=lastpass-1; m++){            s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
              if(agev[m][i]==0) agev[m][i]=agemax+1;  /*        printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2); */
              if(agev[m][i]==1) agev[m][i]=agemax+2;          }
              freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];          ps[i][j]=s2;
              freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];        }
            }      }
          }      /*ps[3][2]=1;*/
        }      
         if  (cptcovn>0) {      for(i=1; i<= nlstate; i++){
          fprintf(ficresp, "\n#********** Variable ");        s1=0;
          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);        for(j=1; j<i; j++)
        fprintf(ficresp, "**********\n#");          s1+=exp(ps[i][j]);
         }        for(j=i+1; j<=nlstate+ndeath; j++)
        for(i=1; i<=nlstate;i++)          s1+=exp(ps[i][j]);
          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);        ps[i][i]=1./(s1+1.);
        fprintf(ficresp, "\n");        for(j=1; j<i; j++)
                  ps[i][j]= exp(ps[i][j])*ps[i][i];
   for(i=(int)agemin; i <= (int)agemax+3; i++){        for(j=i+1; j<=nlstate+ndeath; j++)
     if(i==(int)agemax+3)          ps[i][j]= exp(ps[i][j])*ps[i][i];
       printf("Total");        /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */
     else      } /* end i */
       printf("Age %d", i);      
     for(jk=1; jk <=nlstate ; jk++){      for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){
       for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)        for(jj=1; jj<= nlstate+ndeath; jj++){
         pp[jk] += freq[jk][m][i];          ps[ii][jj]=0;
     }          ps[ii][ii]=1;
     for(jk=1; jk <=nlstate ; jk++){        }
       for(m=-1, pos=0; m <=0 ; m++)      }
         pos += freq[jk][m][i];      
       if(pp[jk]>=1.e-10)  
         printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);  /*        for(ii=1; ii<= nlstate+ndeath; ii++){ */
       else  /*       for(jj=1; jj<= nlstate+ndeath; jj++){ */
         printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);  /*         printf("ddd %lf ",ps[ii][jj]); */
     }  /*       } */
     for(jk=1; jk <=nlstate ; jk++){  /*       printf("\n "); */
       for(m=1, pp[jk]=0; m <=nlstate+ndeath; m++)  /*        } */
         pp[jk] += freq[jk][m][i];  /*        printf("\n ");printf("%lf ",cov[2]); */
     }         /*
     for(jk=1,pos=0; jk <=nlstate ; jk++)        for(i=1; i<= npar; i++) printf("%f ",x[i]);
       pos += pp[jk];        goto end;*/
     for(jk=1; jk <=nlstate ; jk++){      return ps;
       if(pos>=1.e-5)  }
         printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);  
       else  /**************** Product of 2 matrices ******************/
         printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);  
       if( i <= (int) agemax){  double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)
         if(pos>=1.e-5)  {
           fprintf(ficresp," %d %.5f %.0f %.0f",i,pp[jk]/pos, pp[jk],pos);    /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times
       else       b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */
           fprintf(ficresp," %d NaNq %.0f %.0f",i,pp[jk],pos);    /* in, b, out are matrice of pointers which should have been initialized 
       }       before: only the contents of out is modified. The function returns
     }       a pointer to pointers identical to out */
     for(jk=-1; jk <=nlstate+ndeath; jk++)    long i, j, k;
       for(m=-1; m <=nlstate+ndeath; m++)    for(i=nrl; i<= nrh; i++)
         if(freq[jk][m][i] !=0 ) printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);      for(k=ncolol; k<=ncoloh; k++)
     if(i <= (int) agemax)        for(j=ncl,out[i][k]=0.; j<=nch; j++)
       fprintf(ficresp,"\n");          out[i][k] +=in[i][j]*b[j][k];
     printf("\n");  
     }    return out;
     }  }
  }  
    
   fclose(ficresp);  /************* Higher Matrix Product ***************/
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);  
   free_vector(pp,1,nlstate);  double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )
   {
 }  /* End of Freq */    /* Computes the transition matrix starting at age 'age' over 
        'nhstepm*hstepm*stepm' months (i.e. until
 /************* Waves Concatenation ***************/       age (in years)  age+nhstepm*hstepm*stepm/12) by multiplying 
        nhstepm*hstepm matrices. 
 void  concatwav(int wav[], int **dh, int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)       Output is stored in matrix po[i][j][h] for h every 'hstepm' step 
 {       (typically every 2 years instead of every month which is too big 
   /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.       for the memory).
      Death is a valid wave (if date is known).       Model is determined by parameters x and covariates have to be 
      mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i       included manually here. 
      dh[m][i] of dh[mw[mi][i][i] is the delay between two effective waves m=mw[mi][i]  
      and mw[mi+1][i]. dh depends on stepm.       */
      */  
     int i, j, d, h, k;
   int i, mi, m;    double **out, cov[NCOVMAX];
   /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;    double **newm;
      double sum=0., jmean=0.;*/  
     /* Hstepm could be zero and should return the unit matrix */
   int j, k=0,jk, ju, jl;    for (i=1;i<=nlstate+ndeath;i++)
   double sum=0.;      for (j=1;j<=nlstate+ndeath;j++){
   jmin=1e+5;        oldm[i][j]=(i==j ? 1.0 : 0.0);
   jmax=-1;        po[i][j][0]=(i==j ? 1.0 : 0.0);
   jmean=0.;      }
   for(i=1; i<=imx; i++){    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
     mi=0;    for(h=1; h <=nhstepm; h++){
     m=firstpass;      for(d=1; d <=hstepm; d++){
     while(s[m][i] <= nlstate){        newm=savm;
       if(s[m][i]>=1)        /* Covariates have to be included here again */
         mw[++mi][i]=m;        cov[1]=1.;
       if(m >=lastpass)        cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;
         break;        for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
       else        for (k=1; k<=cptcovage;k++)
         m++;          cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
     }/* end while */        for (k=1; k<=cptcovprod;k++)
     if (s[m][i] > nlstate){          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
       mi++;     /* Death is another wave */  
       /* if(mi==0)  never been interviewed correctly before death */  
          /* Only death is a correct wave */        /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/
       mw[mi][i]=m;        /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/
     }        out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, 
                      pmij(pmmij,cov,ncovmodel,x,nlstate));
     wav[i]=mi;        savm=oldm;
     if(mi==0)        oldm=newm;
       printf("Warning, no any valid information for:%d line=%d\n",num[i],i);      }
   }      for(i=1; i<=nlstate+ndeath; i++)
         for(j=1;j<=nlstate+ndeath;j++) {
   for(i=1; i<=imx; i++){          po[i][j][h]=newm[i][j];
     for(mi=1; mi<wav[i];mi++){          /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);
       if (stepm <=0)           */
         dh[mi][i]=1;        }
       else{    } /* end h */
         if (s[mw[mi+1][i]][i] > nlstate) {    return po;
           if (agedc[i] < 2*AGESUP) {  }
           j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12);  
           if(j==0) j=1;  /* Survives at least one month after exam */  
           k=k+1;  /*************** log-likelihood *************/
           if (j >= jmax) jmax=j;  double func( double *x)
           if (j <= jmin) jmin=j;  {
           sum=sum+j;    int i, ii, j, k, mi, d, kk;
           if (j<0) printf("j=%d num=%d ",j,i);    double l, ll[NLSTATEMAX], cov[NCOVMAX];
           }    double **out;
         }    double sw; /* Sum of weights */
         else{    double lli; /* Individual log likelihood */
           j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));    int s1, s2;
           k=k+1;    double bbh, survp;
           if (j >= jmax) jmax=j;    long ipmx;
           else if (j <= jmin)jmin=j;    /*extern weight */
           sum=sum+j;    /* We are differentiating ll according to initial status */
         }    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
         jk= j/stepm;    /*for(i=1;i<imx;i++) 
         jl= j -jk*stepm;      printf(" %d\n",s[4][i]);
         ju= j -(jk+1)*stepm;    */
         if(jl <= -ju)    cov[1]=1.;
           dh[mi][i]=jk;  
         else    for(k=1; k<=nlstate; k++) ll[k]=0.;
           dh[mi][i]=jk+1;  
         if(dh[mi][i]==0)    if(mle==1){
           dh[mi][i]=1; /* At least one step */      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     }        for(mi=1; mi<= wav[i]-1; mi++){
   }          for (ii=1;ii<=nlstate+ndeath;ii++)
   jmean=sum/k;            for (j=1;j<=nlstate+ndeath;j++){
   printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
 }              savm[ii][j]=(ii==j ? 1.0 : 0.0);
 /*********** Tricode ****************************/            }
 void tricode(int *Tvar, int **nbcode, int imx)          for(d=0; d<dh[mi][i]; d++){
 {            newm=savm;
   int Ndum[20],ij=1, k, j, i;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   int cptcode=0;            for (kk=1; kk<=cptcovage;kk++) {
   cptcoveff=0;              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
              }
   for (k=0; k<19; k++) Ndum[k]=0;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   for (k=1; k<=7; k++) ncodemax[k]=0;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
             savm=oldm;
   for (j=1; j<=(cptcovn+2*cptcovprod); j++) {            oldm=newm;
     for (i=1; i<=imx; i++) {          } /* end mult */
       ij=(int)(covar[Tvar[j]][i]);        
       Ndum[ij]++;          /*lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/ /* Original formula */
       /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/          /* But now since version 0.9 we anticipate for bias at large stepm.
       if (ij > cptcode) cptcode=ij;           * If stepm is larger than one month (smallest stepm) and if the exact delay 
     }           * (in months) between two waves is not a multiple of stepm, we rounded to 
            * the nearest (and in case of equal distance, to the lowest) interval but now
     for (i=0; i<=cptcode; i++) {           * we keep into memory the bias bh[mi][i] and also the previous matrix product
       if(Ndum[i]!=0) ncodemax[j]++;           * (i.e to dh[mi][i]-1) saved in 'savm'. Then we inter(extra)polate the
     }           * probability in order to take into account the bias as a fraction of the way
     ij=1;           * from savm to out if bh is negative or even beyond if bh is positive. bh varies
            * -stepm/2 to stepm/2 .
            * For stepm=1 the results are the same as for previous versions of Imach.
     for (i=1; i<=ncodemax[j]; i++) {           * For stepm > 1 the results are less biased than in previous versions. 
       for (k=0; k<=19; k++) {           */
         if (Ndum[k] != 0) {          s1=s[mw[mi][i]][i];
           nbcode[Tvar[j]][ij]=k;          s2=s[mw[mi+1][i]][i];
           ij++;          bbh=(double)bh[mi][i]/(double)stepm; 
         }          /* bias bh is positive if real duration
         if (ij > ncodemax[j]) break;           * is higher than the multiple of stepm and negative otherwise.
       }             */
     }          /* lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2]));*/
   }            if( s2 > nlstate){ 
             /* i.e. if s2 is a death state and if the date of death is known 
  for (k=0; k<19; k++) Ndum[k]=0;               then the contribution to the likelihood is the probability to 
                die between last step unit time and current  step unit time, 
  for (i=1; i<=ncovmodel; i++) {               which is also equal to probability to die before dh 
       ij=Tvar[i];               minus probability to die before dh-stepm . 
       Ndum[ij]++;               In version up to 0.92 likelihood was computed
     }          as if date of death was unknown. Death was treated as any other
           health state: the date of the interview describes the actual state
  ij=1;          and not the date of a change in health state. The former idea was
  for (i=1; i<=10; i++) {          to consider that at each interview the state was recorded
    if((Ndum[i]!=0) && (i<=ncov)){          (healthy, disable or death) and IMaCh was corrected; but when we
      Tvaraff[ij]=i;          introduced the exact date of death then we should have modified
      ij++;          the contribution of an exact death to the likelihood. This new
    }          contribution is smaller and very dependent of the step unit
  }          stepm. It is no more the probability to die between last interview
            and month of death but the probability to survive from last
     cptcoveff=ij-1;          interview up to one month before death multiplied by the
 }          probability to die within a month. Thanks to Chris
           Jackson for correcting this bug.  Former versions increased
 /*********** Health Expectancies ****************/          mortality artificially. The bad side is that we add another loop
           which slows down the processing. The difference can be up to 10%
 void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij)          lower mortality.
 {            */
   /* Health expectancies */            lli=log(out[s1][s2] - savm[s1][s2]);
   int i, j, nhstepm, hstepm, h;  
   double age, agelim,hf;  
   double ***p3mat;          } else if  (s2==-2) {
              for (j=1,survp=0. ; j<=nlstate; j++) 
   fprintf(ficreseij,"# Health expectancies\n");              survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
   fprintf(ficreseij,"# Age");            /*survp += out[s1][j]; */
   for(i=1; i<=nlstate;i++)            lli= log(survp);
     for(j=1; j<=nlstate;j++)          }
       fprintf(ficreseij," %1d-%1d",i,j);          
   fprintf(ficreseij,"\n");          else if  (s2==-4) { 
             for (j=3,survp=0. ; j<=nlstate; j++)  
   hstepm=1*YEARM; /*  Every j years of age (in month) */              survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */            lli= log(survp); 
           } 
   agelim=AGESUP;  
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */          else if  (s2==-5) { 
     /* nhstepm age range expressed in number of stepm */            for (j=1,survp=0. ; j<=2; j++)  
     nhstepm=(int) rint((agelim-age)*YEARM/stepm);              survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
     /* Typically if 20 years = 20*12/6=40 stepm */            lli= log(survp); 
     if (stepm >= YEARM) hstepm=1;          } 
     nhstepm = nhstepm/hstepm;/* Expressed in hstepm, typically 40/4=10 */          
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          else{
     /* Computed by stepm unit matrices, product of hstepm matrices, stored            lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
        in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */            /*  lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2]));*/ /* linear interpolation */
     hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);            } 
           /*lli=(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]);*/
           /*if(lli ==000.0)*/
     for(i=1; i<=nlstate;i++)          /*printf("bbh= %f lli=%f savm=%f out=%f %d\n",bbh,lli,savm[s1][s2], out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]],i); */
       for(j=1; j<=nlstate;j++)          ipmx +=1;
         for (h=0, eij[i][j][(int)age]=0; h<=nhstepm; h++){          sw += weight[i];
           eij[i][j][(int)age] +=p3mat[i][j][h];          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         }        } /* end of wave */
          } /* end of individual */
     hf=1;    }  else if(mle==2){
     if (stepm >= YEARM) hf=stepm/YEARM;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
     fprintf(ficreseij,"%.0f",age );        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     for(i=1; i<=nlstate;i++)        for(mi=1; mi<= wav[i]-1; mi++){
       for(j=1; j<=nlstate;j++){          for (ii=1;ii<=nlstate+ndeath;ii++)
         fprintf(ficreseij," %.4f", hf*eij[i][j][(int)age]);            for (j=1;j<=nlstate+ndeath;j++){
       }              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     fprintf(ficreseij,"\n");              savm[ii][j]=(ii==j ? 1.0 : 0.0);
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);            }
   }          for(d=0; d<=dh[mi][i]; d++){
 }            newm=savm;
             cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
 /************ Variance ******************/            for (kk=1; kk<=cptcovage;kk++) {
 void varevsij(char fileres[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
 {            }
   /* Variance of health expectancies */            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   double **newm;            savm=oldm;
   double **dnewm,**doldm;            oldm=newm;
   int i, j, nhstepm, hstepm, h;          } /* end mult */
   int k, cptcode;        
    double *xp;          s1=s[mw[mi][i]][i];
   double **gp, **gm;          s2=s[mw[mi+1][i]][i];
   double ***gradg, ***trgradg;          bbh=(double)bh[mi][i]/(double)stepm; 
   double ***p3mat;          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
   double age,agelim;          ipmx +=1;
   int theta;          sw += weight[i];
           ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
    fprintf(ficresvij,"# Covariances of life expectancies\n");        } /* end of wave */
   fprintf(ficresvij,"# Age");      } /* end of individual */
   for(i=1; i<=nlstate;i++)    }  else if(mle==3){  /* exponential inter-extrapolation */
     for(j=1; j<=nlstate;j++)      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   fprintf(ficresvij,"\n");        for(mi=1; mi<= wav[i]-1; mi++){
           for (ii=1;ii<=nlstate+ndeath;ii++)
   xp=vector(1,npar);            for (j=1;j<=nlstate+ndeath;j++){
   dnewm=matrix(1,nlstate,1,npar);              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   doldm=matrix(1,nlstate,1,nlstate);              savm[ii][j]=(ii==j ? 1.0 : 0.0);
              }
   hstepm=1*YEARM; /* Every year of age */          for(d=0; d<dh[mi][i]; d++){
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */            newm=savm;
   agelim = AGESUP;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */            for (kk=1; kk<=cptcovage;kk++) {
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
     if (stepm >= YEARM) hstepm=1;            }
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate);            savm=oldm;
     gp=matrix(0,nhstepm,1,nlstate);            oldm=newm;
     gm=matrix(0,nhstepm,1,nlstate);          } /* end mult */
         
     for(theta=1; theta <=npar; theta++){          s1=s[mw[mi][i]][i];
       for(i=1; i<=npar; i++){ /* Computes gradient */          s2=s[mw[mi+1][i]][i];
         xp[i] = x[i] + (i==theta ?delti[theta]:0);          bbh=(double)bh[mi][i]/(double)stepm; 
       }          lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);            ipmx +=1;
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);          sw += weight[i];
       for(j=1; j<= nlstate; j++){          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         for(h=0; h<=nhstepm; h++){        } /* end of wave */
           for(i=1, gp[h][j]=0.;i<=nlstate;i++)      } /* end of individual */
             gp[h][j] += prlim[i][i]*p3mat[i][j][h];    }else if (mle==4){  /* ml=4 no inter-extrapolation */
         }      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
            for(mi=1; mi<= wav[i]-1; mi++){
       for(i=1; i<=npar; i++) /* Computes gradient */          for (ii=1;ii<=nlstate+ndeath;ii++)
         xp[i] = x[i] - (i==theta ?delti[theta]:0);            for (j=1;j<=nlstate+ndeath;j++){
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);                oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);              savm[ii][j]=(ii==j ? 1.0 : 0.0);
       for(j=1; j<= nlstate; j++){            }
         for(h=0; h<=nhstepm; h++){          for(d=0; d<dh[mi][i]; d++){
           for(i=1, gm[h][j]=0.;i<=nlstate;i++)            newm=savm;
             gm[h][j] += prlim[i][i]*p3mat[i][j][h];            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
         }            for (kk=1; kk<=cptcovage;kk++) {
       }              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       for(j=1; j<= nlstate; j++)            }
         for(h=0; h<=nhstepm; h++){          
           gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
         }                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
     } /* End theta */            savm=oldm;
             oldm=newm;
     trgradg =ma3x(0,nhstepm,1,nlstate,1,npar);          } /* end mult */
         
     for(h=0; h<=nhstepm; h++)          s1=s[mw[mi][i]][i];
       for(j=1; j<=nlstate;j++)          s2=s[mw[mi+1][i]][i];
         for(theta=1; theta <=npar; theta++)          if( s2 > nlstate){ 
           trgradg[h][j][theta]=gradg[h][theta][j];            lli=log(out[s1][s2] - savm[s1][s2]);
           }else{
     for(i=1;i<=nlstate;i++)            lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
       for(j=1;j<=nlstate;j++)          }
         vareij[i][j][(int)age] =0.;          ipmx +=1;
     for(h=0;h<=nhstepm;h++){          sw += weight[i];
       for(k=0;k<=nhstepm;k++){          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);  /*      printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
         matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);        } /* end of wave */
         for(i=1;i<=nlstate;i++)      } /* end of individual */
           for(j=1;j<=nlstate;j++)    }else{  /* ml=5 no inter-extrapolation no jackson =0.8a */
             vareij[i][j][(int)age] += doldm[i][j];      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     }        for(mi=1; mi<= wav[i]-1; mi++){
     h=1;          for (ii=1;ii<=nlstate+ndeath;ii++)
     if (stepm >= YEARM) h=stepm/YEARM;            for (j=1;j<=nlstate+ndeath;j++){
     fprintf(ficresvij,"%.0f ",age );              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     for(i=1; i<=nlstate;i++)              savm[ii][j]=(ii==j ? 1.0 : 0.0);
       for(j=1; j<=nlstate;j++){            }
         fprintf(ficresvij," %.4f", h*vareij[i][j][(int)age]);          for(d=0; d<dh[mi][i]; d++){
       }            newm=savm;
     fprintf(ficresvij,"\n");            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     free_matrix(gp,0,nhstepm,1,nlstate);            for (kk=1; kk<=cptcovage;kk++) {
     free_matrix(gm,0,nhstepm,1,nlstate);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);            }
     free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);          
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   } /* End age */                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
              savm=oldm;
   free_vector(xp,1,npar);            oldm=newm;
   free_matrix(doldm,1,nlstate,1,npar);          } /* end mult */
   free_matrix(dnewm,1,nlstate,1,nlstate);        
           s1=s[mw[mi][i]][i];
 }          s2=s[mw[mi+1][i]][i];
           lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
 /************ Variance of prevlim ******************/          ipmx +=1;
 void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)          sw += weight[i];
 {          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   /* Variance of prevalence limit */          /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]);*/
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/        } /* end of wave */
   double **newm;      } /* end of individual */
   double **dnewm,**doldm;    } /* End of if */
   int i, j, nhstepm, hstepm;    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
   int k, cptcode;    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
   double *xp;    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
   double *gp, *gm;    return -l;
   double **gradg, **trgradg;  }
   double age,agelim;  
   int theta;  /*************** log-likelihood *************/
      double funcone( double *x)
   fprintf(ficresvpl,"# Standard deviation of prevalences limit\n");  {
   fprintf(ficresvpl,"# Age");    /* Same as likeli but slower because of a lot of printf and if */
   for(i=1; i<=nlstate;i++)    int i, ii, j, k, mi, d, kk;
       fprintf(ficresvpl," %1d-%1d",i,i);    double l, ll[NLSTATEMAX], cov[NCOVMAX];
   fprintf(ficresvpl,"\n");    double **out;
     double lli; /* Individual log likelihood */
   xp=vector(1,npar);    double llt;
   dnewm=matrix(1,nlstate,1,npar);    int s1, s2;
   doldm=matrix(1,nlstate,1,nlstate);    double bbh, survp;
      /*extern weight */
   hstepm=1*YEARM; /* Every year of age */    /* We are differentiating ll according to initial status */
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
   agelim = AGESUP;    /*for(i=1;i<imx;i++) 
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */      printf(" %d\n",s[4][i]);
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */    */
     if (stepm >= YEARM) hstepm=1;    cov[1]=1.;
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */  
     gradg=matrix(1,npar,1,nlstate);    for(k=1; k<=nlstate; k++) ll[k]=0.;
     gp=vector(1,nlstate);  
     gm=vector(1,nlstate);    for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     for(theta=1; theta <=npar; theta++){      for(mi=1; mi<= wav[i]-1; mi++){
       for(i=1; i<=npar; i++){ /* Computes gradient */        for (ii=1;ii<=nlstate+ndeath;ii++)
         xp[i] = x[i] + (i==theta ?delti[theta]:0);          for (j=1;j<=nlstate+ndeath;j++){
       }            oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);            savm[ii][j]=(ii==j ? 1.0 : 0.0);
       for(i=1;i<=nlstate;i++)          }
         gp[i] = prlim[i][i];        for(d=0; d<dh[mi][i]; d++){
              newm=savm;
       for(i=1; i<=npar; i++) /* Computes gradient */          cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
         xp[i] = x[i] - (i==theta ?delti[theta]:0);          for (kk=1; kk<=cptcovage;kk++) {
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);            cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       for(i=1;i<=nlstate;i++)          }
         gm[i] = prlim[i][i];          out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
                        1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       for(i=1;i<=nlstate;i++)          savm=oldm;
         gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];          oldm=newm;
     } /* End theta */        } /* end mult */
         
     trgradg =matrix(1,nlstate,1,npar);        s1=s[mw[mi][i]][i];
         s2=s[mw[mi+1][i]][i];
     for(j=1; j<=nlstate;j++)        bbh=(double)bh[mi][i]/(double)stepm; 
       for(theta=1; theta <=npar; theta++)        /* bias is positive if real duration
         trgradg[j][theta]=gradg[theta][j];         * is higher than the multiple of stepm and negative otherwise.
          */
     for(i=1;i<=nlstate;i++)        if( s2 > nlstate && (mle <5) ){  /* Jackson */
       varpl[i][(int)age] =0.;          lli=log(out[s1][s2] - savm[s1][s2]);
     matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);        } else if  (s2==-2) {
     matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);          for (j=1,survp=0. ; j<=nlstate; j++) 
     for(i=1;i<=nlstate;i++)            survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
       varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */          lli= log(survp);
         }else if (mle==1){
     fprintf(ficresvpl,"%.0f ",age );          lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
     for(i=1; i<=nlstate;i++)        } else if(mle==2){
       fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
     fprintf(ficresvpl,"\n");        } else if(mle==3){  /* exponential inter-extrapolation */
     free_vector(gp,1,nlstate);          lli= (savm[s1][s2]>(double)1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
     free_vector(gm,1,nlstate);        } else if (mle==4){  /* mle=4 no inter-extrapolation */
     free_matrix(gradg,1,npar,1,nlstate);          lli=log(out[s1][s2]); /* Original formula */
     free_matrix(trgradg,1,nlstate,1,npar);        } else{  /* ml>=5 no inter-extrapolation no jackson =0.8a */
   } /* End age */          lli=log(out[s1][s2]); /* Original formula */
         } /* End of if */
   free_vector(xp,1,npar);        ipmx +=1;
   free_matrix(doldm,1,nlstate,1,npar);        sw += weight[i];
   free_matrix(dnewm,1,nlstate,1,nlstate);        ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   /*       printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
 }        if(globpr){
           fprintf(ficresilk,"%9d %6d %2d %2d %1d %1d %3d %11.6f %8.4f\
    %11.6f %11.6f %11.6f ", \
                   num[i],i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],
 /***********************************************/                  2*weight[i]*lli,out[s1][s2],savm[s1][s2]);
 /**************** Main Program *****************/          for(k=1,llt=0.,l=0.; k<=nlstate; k++){
 /***********************************************/            llt +=ll[k]*gipmx/gsw;
             fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw);
 /*int main(int argc, char *argv[])*/          }
 int main()          fprintf(ficresilk," %10.6f\n", -llt);
 {        }
       } /* end of wave */
   int i,j, k, n=MAXN,iter,m,size,cptcode, cptcod;    } /* end of individual */
   double agedeb, agefin,hf;    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
   double agemin=1.e20, agemax=-1.e20;    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
     l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
   double fret;    if(globpr==0){ /* First time we count the contributions and weights */
   double **xi,tmp,delta;      gipmx=ipmx;
       gsw=sw;
   double dum; /* Dummy variable */    }
   double ***p3mat;    return -l;
   int *indx;  }
   char line[MAXLINE], linepar[MAXLINE];  
   char title[MAXLINE];  
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH];  /*************** function likelione ***********/
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH];  void likelione(FILE *ficres,double p[], int npar, int nlstate, int *globpri, long *ipmx, double *sw, double *fretone, double (*funcone)(double []))
   char filerest[FILENAMELENGTH];  {
   char fileregp[FILENAMELENGTH];    /* This routine should help understanding what is done with 
   char path[80],pathc[80],pathcd[80],pathtot[80],model[20];       the selection of individuals/waves and
   int firstobs=1, lastobs=10;       to check the exact contribution to the likelihood.
   int sdeb, sfin; /* Status at beginning and end */       Plotting could be done.
   int c,  h , cpt,l;     */
   int ju,jl, mi;    int k;
   int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;  
   int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,**adl,*tab;    if(*globpri !=0){ /* Just counts and sums, no printings */
        strcpy(fileresilk,"ilk"); 
   int hstepm, nhstepm;      strcat(fileresilk,fileres);
   double bage, fage, age, agelim, agebase;      if((ficresilk=fopen(fileresilk,"w"))==NULL) {
   double ftolpl=FTOL;        printf("Problem with resultfile: %s\n", fileresilk);
   double **prlim;        fprintf(ficlog,"Problem with resultfile: %s\n", fileresilk);
   double *severity;      }
   double ***param; /* Matrix of parameters */      fprintf(ficresilk, "#individual(line's_record) s1 s2 wave# effective_wave# number_of_matrices_product pij weight -2ln(pij)*weight 0pij_x 0pij_(x-stepm) cumulating_loglikeli_by_health_state(reweighted=-2ll*weightXnumber_of_contribs/sum_of_weights) and_total\n");
   double  *p;      fprintf(ficresilk, "#num_i i s1 s2 mi mw dh likeli weight 2wlli out sav ");
   double **matcov; /* Matrix of covariance */      /*  i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],2*weight[i]*lli,out[s1][s2],savm[s1][s2]); */
   double ***delti3; /* Scale */      for(k=1; k<=nlstate; k++) 
   double *delti; /* Scale */        fprintf(ficresilk," -2*gipw/gsw*weight*ll[%d]++",k);
   double ***eij, ***vareij;      fprintf(ficresilk," -2*gipw/gsw*weight*ll(total)\n");
   double **varpl; /* Variances of prevalence limits by age */    }
   double *epj, vepp;  
   char version[80]="Imach version 64b, May 2001, INED-EUROREVES ";    *fretone=(*funcone)(p);
   char *alph[]={"a","a","b","c","d","e"}, str[4];    if(*globpri !=0){
       fclose(ficresilk);
   char z[1]="c", occ;      fprintf(fichtm,"\n<br>File of contributions to the likelihood: <a href=\"%s\">%s</a><br>\n",subdirf(fileresilk),subdirf(fileresilk));
 #include <sys/time.h>      fflush(fichtm); 
 #include <time.h>    } 
   char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];    return;
   /* long total_usecs;  }
   struct timeval start_time, end_time;  
    
   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */  /*********** Maximum Likelihood Estimation ***************/
   
   void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))
   printf("\nIMACH, Version 0.64b");  {
   printf("\nEnter the parameter file name: ");    int i,j, iter;
     double **xi;
 #ifdef windows    double fret;
   scanf("%s",pathtot);    double fretone; /* Only one call to likelihood */
   getcwd(pathcd, size);    /*  char filerespow[FILENAMELENGTH];*/
   /*cygwin_split_path(pathtot,path,optionfile);    xi=matrix(1,npar,1,npar);
     printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/    for (i=1;i<=npar;i++)
   /* cutv(path,optionfile,pathtot,'\\');*/      for (j=1;j<=npar;j++)
         xi[i][j]=(i==j ? 1.0 : 0.0);
 split(pathtot, path,optionfile);    printf("Powell\n");  fprintf(ficlog,"Powell\n");
   chdir(path);    strcpy(filerespow,"pow"); 
   replace(pathc,path);    strcat(filerespow,fileres);
 #endif    if((ficrespow=fopen(filerespow,"w"))==NULL) {
 #ifdef unix      printf("Problem with resultfile: %s\n", filerespow);
   scanf("%s",optionfile);      fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
 #endif    }
     fprintf(ficrespow,"# Powell\n# iter -2*LL");
 /*-------- arguments in the command line --------*/    for (i=1;i<=nlstate;i++)
       for(j=1;j<=nlstate+ndeath;j++)
   strcpy(fileres,"r");        if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
   strcat(fileres, optionfile);    fprintf(ficrespow,"\n");
   
   /*---------arguments file --------*/    powell(p,xi,npar,ftol,&iter,&fret,func);
   
   if((ficpar=fopen(optionfile,"r"))==NULL)    {    free_matrix(xi,1,npar,1,npar);
     printf("Problem with optionfile %s\n",optionfile);    fclose(ficrespow);
     goto end;    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));
   }    fprintf(ficlog,"\n#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
     fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
   strcpy(filereso,"o");  
   strcat(filereso,fileres);  }
   if((ficparo=fopen(filereso,"w"))==NULL) {  
     printf("Problem with Output resultfile: %s\n", filereso);goto end;  /**** Computes Hessian and covariance matrix ***/
   }  void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))
   {
   /* Reads comments: lines beginning with '#' */    double  **a,**y,*x,pd;
   while((c=getc(ficpar))=='#' && c!= EOF){    double **hess;
     ungetc(c,ficpar);    int i, j,jk;
     fgets(line, MAXLINE, ficpar);    int *indx;
     puts(line);  
     fputs(line,ficparo);    double hessii(double p[], double delta, int theta, double delti[],double (*func)(double []),int npar);
   }    double hessij(double p[], double delti[], int i, int j,double (*func)(double []),int npar);
   ungetc(c,ficpar);    void lubksb(double **a, int npar, int *indx, double b[]) ;
     void ludcmp(double **a, int npar, int *indx, double *d) ;
   fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncov, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);    double gompertz(double p[]);
   printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate,ndeath, maxwav, mle, weightopt,model);    hess=matrix(1,npar,1,npar);
   fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncov,nlstate,ndeath,maxwav, mle, weightopt,model);  
     printf("\nCalculation of the hessian matrix. Wait...\n");
   covar=matrix(0,NCOVMAX,1,n);    fprintf(ficlog,"\nCalculation of the hessian matrix. Wait...\n");
   cptcovn=0;    for (i=1;i<=npar;i++){
   if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;      printf("%d",i);fflush(stdout);
       fprintf(ficlog,"%d",i);fflush(ficlog);
   ncovmodel=2+cptcovn;     
   nvar=ncovmodel-1; /* Suppressing age as a basic covariate */       hess[i][i]=hessii(p,ftolhess,i,delti,func,npar);
        
   /* Read guess parameters */      /*  printf(" %f ",p[i]);
   /* Reads comments: lines beginning with '#' */          printf(" %lf %lf %lf",hess[i][i],ftolhess,delti[i]);*/
   while((c=getc(ficpar))=='#' && c!= EOF){    }
     ungetc(c,ficpar);    
     fgets(line, MAXLINE, ficpar);    for (i=1;i<=npar;i++) {
     puts(line);      for (j=1;j<=npar;j++)  {
     fputs(line,ficparo);        if (j>i) { 
   }          printf(".%d%d",i,j);fflush(stdout);
   ungetc(c,ficpar);          fprintf(ficlog,".%d%d",i,j);fflush(ficlog);
            hess[i][j]=hessij(p,delti,i,j,func,npar);
   param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);          
     for(i=1; i <=nlstate; i++)          hess[j][i]=hess[i][j];    
     for(j=1; j <=nlstate+ndeath-1; j++){          /*printf(" %lf ",hess[i][j]);*/
       fscanf(ficpar,"%1d%1d",&i1,&j1);        }
       fprintf(ficparo,"%1d%1d",i1,j1);      }
       printf("%1d%1d",i,j);    }
       for(k=1; k<=ncovmodel;k++){    printf("\n");
         fscanf(ficpar," %lf",&param[i][j][k]);    fprintf(ficlog,"\n");
         printf(" %lf",param[i][j][k]);  
         fprintf(ficparo," %lf",param[i][j][k]);    printf("\nInverting the hessian to get the covariance matrix. Wait...\n");
       }    fprintf(ficlog,"\nInverting the hessian to get the covariance matrix. Wait...\n");
       fscanf(ficpar,"\n");    
       printf("\n");    a=matrix(1,npar,1,npar);
       fprintf(ficparo,"\n");    y=matrix(1,npar,1,npar);
     }    x=vector(1,npar);
      indx=ivector(1,npar);
   npar= (nlstate+ndeath-1)*nlstate*ncovmodel;    for (i=1;i<=npar;i++)
   p=param[1][1];      for (j=1;j<=npar;j++) a[i][j]=hess[i][j];
      ludcmp(a,npar,indx,&pd);
   /* Reads comments: lines beginning with '#' */  
   while((c=getc(ficpar))=='#' && c!= EOF){    for (j=1;j<=npar;j++) {
     ungetc(c,ficpar);      for (i=1;i<=npar;i++) x[i]=0;
     fgets(line, MAXLINE, ficpar);      x[j]=1;
     puts(line);      lubksb(a,npar,indx,x);
     fputs(line,ficparo);      for (i=1;i<=npar;i++){ 
   }        matcov[i][j]=x[i];
   ungetc(c,ficpar);      }
     }
   delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);  
   delti=vector(1,npar); /* Scale of each paramater (output from hesscov) */    printf("\n#Hessian matrix#\n");
   for(i=1; i <=nlstate; i++){    fprintf(ficlog,"\n#Hessian matrix#\n");
     for(j=1; j <=nlstate+ndeath-1; j++){    for (i=1;i<=npar;i++) { 
       fscanf(ficpar,"%1d%1d",&i1,&j1);      for (j=1;j<=npar;j++) { 
       printf("%1d%1d",i,j);        printf("%.3e ",hess[i][j]);
       fprintf(ficparo,"%1d%1d",i1,j1);        fprintf(ficlog,"%.3e ",hess[i][j]);
       for(k=1; k<=ncovmodel;k++){      }
         fscanf(ficpar,"%le",&delti3[i][j][k]);      printf("\n");
         printf(" %le",delti3[i][j][k]);      fprintf(ficlog,"\n");
         fprintf(ficparo," %le",delti3[i][j][k]);    }
       }  
       fscanf(ficpar,"\n");    /* Recompute Inverse */
       printf("\n");    for (i=1;i<=npar;i++)
       fprintf(ficparo,"\n");      for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];
     }    ludcmp(a,npar,indx,&pd);
   }  
   delti=delti3[1][1];    /*  printf("\n#Hessian matrix recomputed#\n");
    
   /* Reads comments: lines beginning with '#' */    for (j=1;j<=npar;j++) {
   while((c=getc(ficpar))=='#' && c!= EOF){      for (i=1;i<=npar;i++) x[i]=0;
     ungetc(c,ficpar);      x[j]=1;
     fgets(line, MAXLINE, ficpar);      lubksb(a,npar,indx,x);
     puts(line);      for (i=1;i<=npar;i++){ 
     fputs(line,ficparo);        y[i][j]=x[i];
   }        printf("%.3e ",y[i][j]);
   ungetc(c,ficpar);        fprintf(ficlog,"%.3e ",y[i][j]);
        }
   matcov=matrix(1,npar,1,npar);      printf("\n");
   for(i=1; i <=npar; i++){      fprintf(ficlog,"\n");
     fscanf(ficpar,"%s",&str);    }
     printf("%s",str);    */
     fprintf(ficparo,"%s",str);  
     for(j=1; j <=i; j++){    free_matrix(a,1,npar,1,npar);
       fscanf(ficpar," %le",&matcov[i][j]);    free_matrix(y,1,npar,1,npar);
       printf(" %.5le",matcov[i][j]);    free_vector(x,1,npar);
       fprintf(ficparo," %.5le",matcov[i][j]);    free_ivector(indx,1,npar);
     }    free_matrix(hess,1,npar,1,npar);
     fscanf(ficpar,"\n");  
     printf("\n");  
     fprintf(ficparo,"\n");  }
   }  
   for(i=1; i <=npar; i++)  /*************** hessian matrix ****************/
     for(j=i+1;j<=npar;j++)  double hessii(double x[], double delta, int theta, double delti[], double (*func)(double []), int npar)
       matcov[i][j]=matcov[j][i];  {
        int i;
   printf("\n");    int l=1, lmax=20;
     double k1,k2;
     double p2[NPARMAX+1];
     /*-------- data file ----------*/    double res;
     if((ficres =fopen(fileres,"w"))==NULL) {    double delt=0.0001, delts, nkhi=10.,nkhif=1., khi=1.e-4;
       printf("Problem with resultfile: %s\n", fileres);goto end;    double fx;
     }    int k=0,kmax=10;
     fprintf(ficres,"#%s\n",version);    double l1;
      
     if((fic=fopen(datafile,"r"))==NULL)    {    fx=func(x);
       printf("Problem with datafile: %s\n", datafile);goto end;    for (i=1;i<=npar;i++) p2[i]=x[i];
     }    for(l=0 ; l <=lmax; l++){
       l1=pow(10,l);
     n= lastobs;      delts=delt;
     severity = vector(1,maxwav);      for(k=1 ; k <kmax; k=k+1){
     outcome=imatrix(1,maxwav+1,1,n);        delt = delta*(l1*k);
     num=ivector(1,n);        p2[theta]=x[theta] +delt;
     moisnais=vector(1,n);        k1=func(p2)-fx;
     annais=vector(1,n);        p2[theta]=x[theta]-delt;
     moisdc=vector(1,n);        k2=func(p2)-fx;
     andc=vector(1,n);        /*res= (k1-2.0*fx+k2)/delt/delt; */
     agedc=vector(1,n);        res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */
     cod=ivector(1,n);        
     weight=vector(1,n);  #ifdef DEBUG
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */        printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
     mint=matrix(1,maxwav,1,n);        fprintf(ficlog,"%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
     anint=matrix(1,maxwav,1,n);  #endif
     s=imatrix(1,maxwav+1,1,n);        /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */
     adl=imatrix(1,maxwav+1,1,n);            if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){
     tab=ivector(1,NCOVMAX);          k=kmax;
     ncodemax=ivector(1,8);        }
         else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */
     i=1;          k=kmax; l=lmax*10.;
     while (fgets(line, MAXLINE, fic) != NULL)    {        }
       if ((i >= firstobs) && (i <=lastobs)) {        else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){ 
                  delts=delt;
         for (j=maxwav;j>=1;j--){        }
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb);      }
           strcpy(line,stra);    }
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);    delti[theta]=delts;
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);    return res; 
         }    
          }
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);  
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);  double hessij( double x[], double delti[], int thetai,int thetaj,double (*func)(double []),int npar)
   {
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);    int i;
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);    int l=1, l1, lmax=20;
     double k1,k2,k3,k4,res,fx;
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);    double p2[NPARMAX+1];
         for (j=ncov;j>=1;j--){    int k;
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);  
         }    fx=func(x);
         num[i]=atol(stra);    for (k=1; k<=2; k++) {
       for (i=1;i<=npar;i++) p2[i]=x[i];
         /*printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));*/      p2[thetai]=x[thetai]+delti[thetai]/k;
       p2[thetaj]=x[thetaj]+delti[thetaj]/k;
         i=i+1;      k1=func(p2)-fx;
       }    
     }      p2[thetai]=x[thetai]+delti[thetai]/k;
       p2[thetaj]=x[thetaj]-delti[thetaj]/k;
     /*scanf("%d",i);*/      k2=func(p2)-fx;
   imx=i-1; /* Number of individuals */    
       p2[thetai]=x[thetai]-delti[thetai]/k;
   /* Calculation of the number of parameter from char model*/      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
   Tvar=ivector(1,15);      k3=func(p2)-fx;
   Tprod=ivector(1,15);    
   Tvaraff=ivector(1,15);      p2[thetai]=x[thetai]-delti[thetai]/k;
   Tvard=imatrix(1,15,1,2);      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
   Tage=ivector(1,15);            k4=func(p2)-fx;
          res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */
   if (strlen(model) >1){  #ifdef DEBUG
     j=0, j1=0, k1=1, k2=1;      printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
     j=nbocc(model,'+');      fprintf(ficlog,"%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
     j1=nbocc(model,'*');  #endif
     cptcovn=j+1;    }
     cptcovprod=j1;    return res;
      }
      
     strcpy(modelsav,model);  /************** Inverse of matrix **************/
     if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){  void ludcmp(double **a, int n, int *indx, double *d) 
       printf("Error. Non available option model=%s ",model);  { 
       goto end;    int i,imax,j,k; 
     }    double big,dum,sum,temp; 
        double *vv; 
     for(i=(j+1); i>=1;i--){   
       cutv(stra,strb,modelsav,'+');    vv=vector(1,n); 
       if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav);    *d=1.0; 
       /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/    for (i=1;i<=n;i++) { 
       /*scanf("%d",i);*/      big=0.0; 
       if (strchr(strb,'*')) {      for (j=1;j<=n;j++) 
         cutv(strd,strc,strb,'*');        if ((temp=fabs(a[i][j])) > big) big=temp; 
         if (strcmp(strc,"age")==0) {      if (big == 0.0) nrerror("Singular matrix in routine ludcmp"); 
           cptcovprod--;      vv[i]=1.0/big; 
           cutv(strb,stre,strd,'V');    } 
           Tvar[i]=atoi(stre);    for (j=1;j<=n;j++) { 
           cptcovage++;      for (i=1;i<j;i++) { 
             Tage[cptcovage]=i;        sum=a[i][j]; 
             /*printf("stre=%s ", stre);*/        for (k=1;k<i;k++) sum -= a[i][k]*a[k][j]; 
         }        a[i][j]=sum; 
         else if (strcmp(strd,"age")==0) {      } 
           cptcovprod--;      big=0.0; 
           cutv(strb,stre,strc,'V');      for (i=j;i<=n;i++) { 
           Tvar[i]=atoi(stre);        sum=a[i][j]; 
           cptcovage++;        for (k=1;k<j;k++) 
           Tage[cptcovage]=i;          sum -= a[i][k]*a[k][j]; 
         }        a[i][j]=sum; 
         else {        if ( (dum=vv[i]*fabs(sum)) >= big) { 
           cutv(strb,stre,strc,'V');          big=dum; 
           Tvar[i]=ncov+k1;          imax=i; 
           cutv(strb,strc,strd,'V');        } 
           Tprod[k1]=i;      } 
           Tvard[k1][1]=atoi(strc);      if (j != imax) { 
           Tvard[k1][2]=atoi(stre);        for (k=1;k<=n;k++) { 
           Tvar[cptcovn+k2]=Tvard[k1][1];          dum=a[imax][k]; 
           Tvar[cptcovn+k2+1]=Tvard[k1][2];          a[imax][k]=a[j][k]; 
           for (k=1; k<=lastobs;k++)          a[j][k]=dum; 
             covar[ncov+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];        } 
           k1++;        *d = -(*d); 
           k2=k2+2;        vv[imax]=vv[j]; 
         }      } 
       }      indx[j]=imax; 
       else {      if (a[j][j] == 0.0) a[j][j]=TINY; 
         /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/      if (j != n) { 
        /*  scanf("%d",i);*/        dum=1.0/(a[j][j]); 
       cutv(strd,strc,strb,'V');        for (i=j+1;i<=n;i++) a[i][j] *= dum; 
       Tvar[i]=atoi(strc);      } 
       }    } 
       strcpy(modelsav,stra);      free_vector(vv,1,n);  /* Doesn't work */
       /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);  ;
         scanf("%d",i);*/  } 
     }  
 }  void lubksb(double **a, int n, int *indx, double b[]) 
    { 
   /*printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);    int i,ii=0,ip,j; 
   printf("cptcovprod=%d ", cptcovprod);    double sum; 
   scanf("%d ",i);*/   
     fclose(fic);    for (i=1;i<=n;i++) { 
       ip=indx[i]; 
     /*  if(mle==1){*/      sum=b[ip]; 
     if (weightopt != 1) { /* Maximisation without weights*/      b[ip]=b[i]; 
       for(i=1;i<=n;i++) weight[i]=1.0;      if (ii) 
     }        for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j]; 
     /*-calculation of age at interview from date of interview and age at death -*/      else if (sum) ii=i; 
     agev=matrix(1,maxwav,1,imx);      b[i]=sum; 
        } 
     for (i=1; i<=imx; i++)  {    for (i=n;i>=1;i--) { 
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);      sum=b[i]; 
       for(m=1; (m<= maxwav); m++){      for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j]; 
         if(s[m][i] >0){      b[i]=sum/a[i][i]; 
           if (s[m][i] == nlstate+1) {    } 
             if(agedc[i]>0)  } 
               if(moisdc[i]!=99 && andc[i]!=9999)  
               agev[m][i]=agedc[i];  void pstamp(FILE *fichier)
             else {  {
               if (andc[i]!=9999){    fprintf(fichier,"# %s.%s\n#%s\n#%s\n# %s", optionfilefiname,optionfilext,version,fullversion,strstart);
               printf("Warning negative age at death: %d line:%d\n",num[i],i);  }
               agev[m][i]=-1;  
               }  /************ Frequencies ********************/
             }  void  freqsummary(char fileres[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, int *Tvaraff, int **nbcode, int *ncodemax,double **mint,double **anint, char strstart[])
           }  {  /* Some frequencies */
           else if(s[m][i] !=9){ /* Should no more exist */    
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);    int i, m, jk, k1,i1, j1, bool, z1,z2,j;
             if(mint[m][i]==99 || anint[m][i]==9999)    int first;
               agev[m][i]=1;    double ***freq; /* Frequencies */
             else if(agev[m][i] <agemin){    double *pp, **prop;
               agemin=agev[m][i];    double pos,posprop, k2, dateintsum=0,k2cpt=0;
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/    char fileresp[FILENAMELENGTH];
             }    
             else if(agev[m][i] >agemax){    pp=vector(1,nlstate);
               agemax=agev[m][i];    prop=matrix(1,nlstate,iagemin,iagemax+3);
              /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/    strcpy(fileresp,"p");
             }    strcat(fileresp,fileres);
             /*agev[m][i]=anint[m][i]-annais[i];*/    if((ficresp=fopen(fileresp,"w"))==NULL) {
             /*   agev[m][i] = age[i]+2*m;*/      printf("Problem with prevalence resultfile: %s\n", fileresp);
           }      fprintf(ficlog,"Problem with prevalence resultfile: %s\n", fileresp);
           else { /* =9 */      exit(0);
             agev[m][i]=1;    }
             s[m][i]=-1;    freq= ma3x(-5,nlstate+ndeath,-5,nlstate+ndeath,iagemin,iagemax+3);
           }    j1=0;
         }    
         else /*= 0 Unknown */    j=cptcoveff;
           agev[m][i]=1;    if (cptcovn<1) {j=1;ncodemax[1]=1;}
       }  
        first=1;
     }  
     for (i=1; i<=imx; i++)  {    for(k1=1; k1<=j;k1++){
       for(m=1; (m<= maxwav); m++){      for(i1=1; i1<=ncodemax[k1];i1++){
         if (s[m][i] > (nlstate+ndeath)) {        j1++;
           printf("Error: Wrong value in nlstate or ndeath\n");          /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);
           goto end;          scanf("%d", i);*/
         }        for (i=-5; i<=nlstate+ndeath; i++)  
       }          for (jk=-5; jk<=nlstate+ndeath; jk++)  
     }            for(m=iagemin; m <= iagemax+3; m++)
               freq[i][jk][m]=0;
 printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);  
       for (i=1; i<=nlstate; i++)  
     free_vector(severity,1,maxwav);        for(m=iagemin; m <= iagemax+3; m++)
     free_imatrix(outcome,1,maxwav+1,1,n);          prop[i][m]=0;
     free_vector(moisnais,1,n);        
     free_vector(annais,1,n);        dateintsum=0;
     free_matrix(mint,1,maxwav,1,n);        k2cpt=0;
     free_matrix(anint,1,maxwav,1,n);        for (i=1; i<=imx; i++) {
     free_vector(moisdc,1,n);          bool=1;
     free_vector(andc,1,n);          if  (cptcovn>0) {
             for (z1=1; z1<=cptcoveff; z1++) 
                  if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
     wav=ivector(1,imx);                bool=0;
     dh=imatrix(1,lastpass-firstpass+1,1,imx);          }
     mw=imatrix(1,lastpass-firstpass+1,1,imx);          if (bool==1){
                for(m=firstpass; m<=lastpass; m++){
     /* Concatenates waves */              k2=anint[m][i]+(mint[m][i]/12.);
       concatwav(wav, dh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);              /*if ((k2>=dateprev1) && (k2<=dateprev2)) {*/
                 if(agev[m][i]==0) agev[m][i]=iagemax+1;
                 if(agev[m][i]==1) agev[m][i]=iagemax+2;
       Tcode=ivector(1,100);                if (s[m][i]>0 && s[m][i]<=nlstate) prop[s[m][i]][(int)agev[m][i]] += weight[i];
       nbcode=imatrix(0,NCOVMAX,0,NCOVMAX);                if (m<lastpass) {
       ncodemax[1]=1;                  freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];
       if (cptcovn > 0) tricode(Tvar,nbcode,imx);                  freq[s[m][i]][s[m+1][i]][iagemax+3] += weight[i];
                      }
    codtab=imatrix(1,100,1,10);                
    h=0;                if ((agev[m][i]>1) && (agev[m][i]< (iagemax+3))) {
    m=pow(2,cptcoveff);                  dateintsum=dateintsum+k2;
                    k2cpt++;
    for(k=1;k<=cptcoveff; k++){                }
      for(i=1; i <=(m/pow(2,k));i++){                /*}*/
        for(j=1; j <= ncodemax[k]; j++){            }
          for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){          }
            h++;        }
            if (h>m) h=1;codtab[h][k]=j;         
          }        /*      fprintf(ficresp, "#Count between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
        }        pstamp(ficresp);
      }        if  (cptcovn>0) {
    }          fprintf(ficresp, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresp, "**********\n#");
    /*for(i=1; i <=m ;i++){        }
      for(k=1; k <=cptcovn; k++){        for(i=1; i<=nlstate;i++) 
        printf("i=%d k=%d %d %d",i,k,codtab[i][k], cptcoveff);          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);
      }        fprintf(ficresp, "\n");
      printf("\n");        
    }        for(i=iagemin; i <= iagemax+3; i++){
    scanf("%d",i);*/          if(i==iagemax+3){
                fprintf(ficlog,"Total");
    /* Calculates basic frequencies. Computes observed prevalence at single age          }else{
        and prints on file fileres'p'. */            if(first==1){
   freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax);              first=0;
               printf("See log file for details...\n");
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */            }
     oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */            fprintf(ficlog,"Age %d", i);
     newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */          }
     savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */          for(jk=1; jk <=nlstate ; jk++){
     oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */            for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)
                  pp[jk] += freq[jk][m][i]; 
     /* For Powell, parameters are in a vector p[] starting at p[1]          }
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */          for(jk=1; jk <=nlstate ; jk++){
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */            for(m=-1, pos=0; m <=0 ; m++)
               pos += freq[jk][m][i];
     if(mle==1){            if(pp[jk]>=1.e-10){
     mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);              if(first==1){
     }              printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
                  }
     /*--------- results files --------------*/              fprintf(ficlog," %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
     fprintf(ficres,"\ntitle=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate, ndeath, maxwav, mle,weightopt,model);            }else{
                  if(first==1)
    jk=1;                printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
    fprintf(ficres,"# Parameters\n");              fprintf(ficlog," %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
    printf("# Parameters\n");            }
    for(i=1,jk=1; i <=nlstate; i++){          }
      for(k=1; k <=(nlstate+ndeath); k++){  
        if (k != i)          for(jk=1; jk <=nlstate ; jk++){
          {            for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)
            printf("%d%d ",i,k);              pp[jk] += freq[jk][m][i];
            fprintf(ficres,"%1d%1d ",i,k);          }       
            for(j=1; j <=ncovmodel; j++){          for(jk=1,pos=0,posprop=0; jk <=nlstate ; jk++){
              printf("%f ",p[jk]);            pos += pp[jk];
              fprintf(ficres,"%f ",p[jk]);            posprop += prop[jk][i];
              jk++;          }
            }          for(jk=1; jk <=nlstate ; jk++){
            printf("\n");            if(pos>=1.e-5){
            fprintf(ficres,"\n");              if(first==1)
          }                printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
      }              fprintf(ficlog," %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
    }            }else{
  if(mle==1){              if(first==1)
     /* Computing hessian and covariance matrix */                printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     ftolhess=ftol; /* Usually correct */              fprintf(ficlog," %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     hesscov(matcov, p, npar, delti, ftolhess, func);            }
  }            if( i <= iagemax){
     fprintf(ficres,"# Scales\n");              if(pos>=1.e-5){
     printf("# Scales\n");                fprintf(ficresp," %d %.5f %.0f %.0f",i,prop[jk][i]/posprop, prop[jk][i],posprop);
      for(i=1,jk=1; i <=nlstate; i++){                /*probs[i][jk][j1]= pp[jk]/pos;*/
       for(j=1; j <=nlstate+ndeath; j++){                /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/
         if (j!=i) {              }
           fprintf(ficres,"%1d%1d",i,j);              else
           printf("%1d%1d",i,j);                fprintf(ficresp," %d NaNq %.0f %.0f",i,prop[jk][i],posprop);
           for(k=1; k<=ncovmodel;k++){            }
             printf(" %.5e",delti[jk]);          }
             fprintf(ficres," %.5e",delti[jk]);          
             jk++;          for(jk=-1; jk <=nlstate+ndeath; jk++)
           }            for(m=-1; m <=nlstate+ndeath; m++)
           printf("\n");              if(freq[jk][m][i] !=0 ) {
           fprintf(ficres,"\n");              if(first==1)
         }                printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);
       }                fprintf(ficlog," %d%d=%.0f",jk,m,freq[jk][m][i]);
       }              }
              if(i <= iagemax)
     k=1;            fprintf(ficresp,"\n");
     fprintf(ficres,"# Covariance\n");          if(first==1)
     printf("# Covariance\n");            printf("Others in log...\n");
     for(i=1;i<=npar;i++){          fprintf(ficlog,"\n");
       /*  if (k>nlstate) k=1;        }
       i1=(i-1)/(ncovmodel*nlstate)+1;      }
       fprintf(ficres,"%s%d%d",alph[k],i1,tab[i]);    }
       printf("%s%d%d",alph[k],i1,tab[i]);*/    dateintmean=dateintsum/k2cpt; 
       fprintf(ficres,"%3d",i);   
       printf("%3d",i);    fclose(ficresp);
       for(j=1; j<=i;j++){    free_ma3x(freq,-5,nlstate+ndeath,-5,nlstate+ndeath, iagemin, iagemax+3);
         fprintf(ficres," %.5e",matcov[i][j]);    free_vector(pp,1,nlstate);
         printf(" %.5e",matcov[i][j]);    free_matrix(prop,1,nlstate,iagemin, iagemax+3);
       }    /* End of Freq */
       fprintf(ficres,"\n");  }
       printf("\n");  
       k++;  /************ Prevalence ********************/
     }  void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass)
      {  
     while((c=getc(ficpar))=='#' && c!= EOF){    /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people
       ungetc(c,ficpar);       in each health status at the date of interview (if between dateprev1 and dateprev2).
       fgets(line, MAXLINE, ficpar);       We still use firstpass and lastpass as another selection.
       puts(line);    */
       fputs(line,ficparo);   
     }    int i, m, jk, k1, i1, j1, bool, z1,z2,j;
     ungetc(c,ficpar);    double ***freq; /* Frequencies */
      double *pp, **prop;
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);    double pos,posprop; 
        double  y2; /* in fractional years */
     if (fage <= 2) {    int iagemin, iagemax;
       bage = agemin;  
       fage = agemax;    iagemin= (int) agemin;
     }    iagemax= (int) agemax;
     /*pp=vector(1,nlstate);*/
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");    prop=matrix(1,nlstate,iagemin,iagemax+3); 
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);    /*  freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);*/
     j1=0;
        
 /*------------ gnuplot -------------*/    j=cptcoveff;
 chdir(pathcd);    if (cptcovn<1) {j=1;ncodemax[1]=1;}
   if((ficgp=fopen("graph.plt","w"))==NULL) {    
     printf("Problem with file graph.gp");goto end;    for(k1=1; k1<=j;k1++){
   }      for(i1=1; i1<=ncodemax[k1];i1++){
 #ifdef windows        j1++;
   fprintf(ficgp,"cd \"%s\" \n",pathc);        
 #endif        for (i=1; i<=nlstate; i++)  
 m=pow(2,cptcoveff);          for(m=iagemin; m <= iagemax+3; m++)
              prop[i][m]=0.0;
  /* 1eme*/       
   for (cpt=1; cpt<= nlstate ; cpt ++) {        for (i=1; i<=imx; i++) { /* Each individual */
    for (k1=1; k1<= m ; k1 ++) {          bool=1;
           if  (cptcovn>0) {
 #ifdef windows            for (z1=1; z1<=cptcoveff; z1++) 
     fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"vpl%s\" every :::%d::%d u 1:2 \"\%%lf",agemin,fage,fileres,k1-1,k1-1);              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
 #endif                bool=0;
 #ifdef unix          } 
 fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nplot [%.f:%.f] \"vpl%s\" u 1:2 \"\%%lf",agemin,fage,fileres);          if (bool==1) { 
 #endif            for(m=firstpass; m<=lastpass; m++){/* Other selection (we can limit to certain interviews*/
               y2=anint[m][i]+(mint[m][i]/12.); /* Fractional date in year */
 for (i=1; i<= nlstate ; i ++) {              if ((y2>=dateprev1) && (y2<=dateprev2)) { /* Here is the main selection (fractional years) */
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");                if(agev[m][i]==0) agev[m][i]=iagemax+1;
   else fprintf(ficgp," \%%*lf (\%%*lf)");                if(agev[m][i]==1) agev[m][i]=iagemax+2;
 }                if((int)agev[m][i] <iagemin || (int)agev[m][i] >iagemax+3) printf("Error on individual =%d agev[m][i]=%f m=%d\n",i, agev[m][i],m); 
     fprintf(ficgp,"\" t\"Stationary prevalence\" w l 0,\"vpl%s\" every :::%d::%d u 1:($2+2*$3) \"\%%lf",fileres,k1-1,k1-1);                if (s[m][i]>0 && s[m][i]<=nlstate) { 
     for (i=1; i<= nlstate ; i ++) {                  /*if(i>4620) printf(" i=%d m=%d s[m][i]=%d (int)agev[m][i]=%d weight[i]=%f prop=%f\n",i,m,s[m][i],(int)agev[m][m],weight[i],prop[s[m][i]][(int)agev[m][i]]);*/
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");                  prop[s[m][i]][(int)agev[m][i]] += weight[i];
   else fprintf(ficgp," \%%*lf (\%%*lf)");                  prop[s[m][i]][iagemax+3] += weight[i]; 
 }                } 
   fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"vpl%s\" every :::%d::%d u 1:($2-2*$3) \"\%%lf",fileres,k1-1,k1-1);              }
      for (i=1; i<= nlstate ; i ++) {            } /* end selection of waves */
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");          }
   else fprintf(ficgp," \%%*lf (\%%*lf)");        }
 }          for(i=iagemin; i <= iagemax+3; i++){  
      fprintf(ficgp,"\" t\"\" w l 1,\"p%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",fileres,k1-1,k1-1,2+4*(cpt-1));          
 #ifdef unix          for(jk=1,posprop=0; jk <=nlstate ; jk++) { 
 fprintf(ficgp,"\nset ter gif small size 400,300");            posprop += prop[jk][i]; 
 #endif          } 
 fprintf(ficgp,"\nset out \"v%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);  
    }          for(jk=1; jk <=nlstate ; jk++){     
   }            if( i <=  iagemax){ 
   /*2 eme*/              if(posprop>=1.e-5){ 
                 probs[i][jk][j1]= prop[jk][i]/posprop;
   for (k1=1; k1<= m ; k1 ++) {              } 
     fprintf(ficgp,"set ylabel \"Years\" \nset ter gif small size 400,300\nplot [%.f:%.f] ",agemin,fage);            } 
              }/* end jk */ 
     for (i=1; i<= nlstate+1 ; i ++) {        }/* end i */ 
       k=2*i;      } /* end i1 */
       fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:2 \"\%%lf",fileres,k1-1,k1-1);    } /* end k1 */
       for (j=1; j<= nlstate+1 ; j ++) {    
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");    /*  free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);*/
   else fprintf(ficgp," \%%*lf (\%%*lf)");    /*free_vector(pp,1,nlstate);*/
 }      free_matrix(prop,1,nlstate, iagemin,iagemax+3);
       if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");  }  /* End of prevalence */
       else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);  
     fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",fileres,k1-1,k1-1);  /************* Waves Concatenation ***************/
       for (j=1; j<= nlstate+1 ; j ++) {  
         if (j==i) fprintf(ficgp," \%%lf (\%%lf)");  void  concatwav(int wav[], int **dh, int **bh,  int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)
         else fprintf(ficgp," \%%*lf (\%%*lf)");  {
 }      /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.
       fprintf(ficgp,"\" t\"\" w l 0,");       Death is a valid wave (if date is known).
      fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",fileres,k1-1,k1-1);       mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i
       for (j=1; j<= nlstate+1 ; j ++) {       dh[m][i] or dh[mw[mi][i]][i] is the delay between two effective waves m=mw[mi][i]
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");       and mw[mi+1][i]. dh depends on stepm.
   else fprintf(ficgp," \%%*lf (\%%*lf)");       */
 }    
       if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");    int i, mi, m;
       else fprintf(ficgp,"\" t\"\" w l 0,");    /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;
     }       double sum=0., jmean=0.;*/
     fprintf(ficgp,"\nset out \"e%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),k1);    int first;
   }    int j, k=0,jk, ju, jl;
      double sum=0.;
   /*3eme*/    first=0;
     jmin=1e+5;
   for (k1=1; k1<= m ; k1 ++) {    jmax=-1;
     for (cpt=1; cpt<= nlstate ; cpt ++) {    jmean=0.;
       k=2+nlstate*(cpt-1);    for(i=1; i<=imx; i++){
       fprintf(ficgp,"set ter gif small size 400,300\nplot [%.f:%.f] \"e%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",agemin,fage,fileres,k1-1,k1-1,k,cpt);      mi=0;
       for (i=1; i< nlstate ; i ++) {      m=firstpass;
         fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",fileres,k1-1,k1-1,k+i,cpt,i+1);      while(s[m][i] <= nlstate){
       }        if(s[m][i]>=1 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5)
       fprintf(ficgp,"\nset out \"exp%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);          mw[++mi][i]=m;
     }        if(m >=lastpass)
   }          break;
          else
   /* CV preval stat */          m++;
   for (k1=1; k1<= m ; k1 ++) {      }/* end while */
     for (cpt=1; cpt<nlstate ; cpt ++) {      if (s[m][i] > nlstate){
       k=3;        mi++;     /* Death is another wave */
       fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",agemin,agemax,fileres,k1,k+cpt+1,k+1);        /* if(mi==0)  never been interviewed correctly before death */
       for (i=1; i< nlstate ; i ++)           /* Only death is a correct wave */
         fprintf(ficgp,"+$%d",k+i+1);        mw[mi][i]=m;
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);      }
        
       l=3+(nlstate+ndeath)*cpt;      wav[i]=mi;
       fprintf(ficgp,",\"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",fileres,k1,l+cpt+1,l+1);      if(mi==0){
       for (i=1; i< nlstate ; i ++) {        nbwarn++;
         l=3+(nlstate+ndeath)*cpt;        if(first==0){
         fprintf(ficgp,"+$%d",l+i+1);          printf("Warning! No valid information for individual %ld line=%d (skipped) and may be others, see log file\n",num[i],i);
       }          first=1;
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);          }
       fprintf(ficgp,"set out \"p%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);        if(first==1){
     }          fprintf(ficlog,"Warning! No valid information for individual %ld line=%d (skipped)\n",num[i],i);
   }        }
       } /* end mi==0 */
   /* proba elementaires */    } /* End individuals */
    for(i=1,jk=1; i <=nlstate; i++){  
     for(k=1; k <=(nlstate+ndeath); k++){    for(i=1; i<=imx; i++){
       if (k != i) {      for(mi=1; mi<wav[i];mi++){
         for(j=1; j <=ncovmodel; j++){        if (stepm <=0)
           /*fprintf(ficgp,"%s%1d%1d=%f ",alph[j],i,k,p[jk]);*/          dh[mi][i]=1;
           /*fprintf(ficgp,"%s",alph[1]);*/        else{
           fprintf(ficgp,"p%d=%f ",jk,p[jk]);          if (s[mw[mi+1][i]][i] > nlstate) { /* A death */
           jk++;            if (agedc[i] < 2*AGESUP) {
           fprintf(ficgp,"\n");              j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12); 
         }              if(j==0) j=1;  /* Survives at least one month after exam */
       }              else if(j<0){
     }                nberr++;
     }                printf("Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
                 j=1; /* Temporary Dangerous patch */
   for(jk=1; jk <=m; jk++) {                printf("   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
   fprintf(ficgp,"\nset ter gif small size 400,300\nset log y\nplot  [%.f:%.f] ",agemin,agemax);                fprintf(ficlog,"Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
    i=1;                fprintf(ficlog,"   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
    for(k2=1; k2<=nlstate; k2++) {              }
      k3=i;              k=k+1;
      for(k=1; k<=(nlstate+ndeath); k++) {              if (j >= jmax){
        if (k != k2){                jmax=j;
         fprintf(ficgp," exp(p%d+p%d*x",i,i+1);                ijmax=i;
 ij=1;              }
         for(j=3; j <=ncovmodel; j++) {              if (j <= jmin){
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {                jmin=j;
             fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);                ijmin=i;
             ij++;              }
           }              sum=sum+j;
           else              /*if (j<0) printf("j=%d num=%d \n",j,i);*/
           fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);              /*    printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
         }            }
           fprintf(ficgp,")/(1");          }
                  else{
         for(k1=1; k1 <=nlstate; k1++){              j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));
           fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);  /*        if (j<0) printf("%d %lf %lf %d %d %d\n", i,agev[mw[mi+1][i]][i], agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]); */
 ij=1;  
           for(j=3; j <=ncovmodel; j++){            k=k+1;
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {            if (j >= jmax) {
             fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);              jmax=j;
             ij++;              ijmax=i;
           }            }
           else            else if (j <= jmin){
             fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);              jmin=j;
           }              ijmin=i;
           fprintf(ficgp,")");            }
         }            /*        if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */
         fprintf(ficgp,") t \"p%d%d\" ", k2,k);            /*printf("%d %lf %d %d %d\n", i,agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);*/
         if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");            if(j<0){
         i=i+ncovmodel;              nberr++;
        }              printf("Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
      }              fprintf(ficlog,"Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
    }            }
    fprintf(ficgp,"\nset out \"pe%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),jk);            sum=sum+j;
   }          }
              jk= j/stepm;
   fclose(ficgp);          jl= j -jk*stepm;
              ju= j -(jk+1)*stepm;
 chdir(path);          if(mle <=1){ /* only if we use a the linear-interpoloation pseudo-likelihood */
     free_matrix(agev,1,maxwav,1,imx);            if(jl==0){
     free_ivector(wav,1,imx);              dh[mi][i]=jk;
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);              bh[mi][i]=0;
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);            }else{ /* We want a negative bias in order to only have interpolation ie
                        * at the price of an extra matrix product in likelihood */
     free_imatrix(s,1,maxwav+1,1,n);              dh[mi][i]=jk+1;
                  bh[mi][i]=ju;
                }
     free_ivector(num,1,n);          }else{
     free_vector(agedc,1,n);            if(jl <= -ju){
     free_vector(weight,1,n);              dh[mi][i]=jk;
     /*free_matrix(covar,1,NCOVMAX,1,n);*/              bh[mi][i]=jl;       /* bias is positive if real duration
     fclose(ficparo);                                   * is higher than the multiple of stepm and negative otherwise.
     fclose(ficres);                                   */
     /*  }*/            }
                else{
    /*________fin mle=1_________*/              dh[mi][i]=jk+1;
                  bh[mi][i]=ju;
             }
              if(dh[mi][i]==0){
     /* No more information from the sample is required now */              dh[mi][i]=1; /* At least one step */
   /* Reads comments: lines beginning with '#' */              bh[mi][i]=ju; /* At least one step */
   while((c=getc(ficpar))=='#' && c!= EOF){              /*  printf(" bh=%d ju=%d jl=%d dh=%d jk=%d stepm=%d %d\n",bh[mi][i],ju,jl,dh[mi][i],jk,stepm,i);*/
     ungetc(c,ficpar);            }
     fgets(line, MAXLINE, ficpar);          } /* end if mle */
     puts(line);        }
     fputs(line,ficparo);      } /* end wave */
   }    }
   ungetc(c,ficpar);    jmean=sum/k;
      printf("Delay (in months) between two waves Min=%d (for indiviudal %ld) Max=%d (%ld) Mean=%f\n\n ",jmin, num[ijmin], jmax, num[ijmax], jmean);
   fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);    fprintf(ficlog,"Delay (in months) between two waves Min=%d (for indiviudal %ld) Max=%d (%ld) Mean=%f\n\n ",jmin, ijmin, jmax, ijmax, jmean);
   printf("agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax, bage, fage);   }
   fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);  
 /*--------- index.htm --------*/  /*********** Tricode ****************************/
   void tricode(int *Tvar, int **nbcode, int imx)
   strcpy(optionfilehtm,optionfile);  {
   strcat(optionfilehtm,".htm");    
   if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {    int Ndum[20],ij=1, k, j, i, maxncov=19;
     printf("Problem with %s \n",optionfilehtm);goto end;    int cptcode=0;
   }    cptcoveff=0; 
    
  fprintf(fichtm,"<body><ul> <font size=\"6\">Imach, Version 0.64b </font> <hr size=\"2\" color=\"#EC5E5E\">    for (k=0; k<maxncov; k++) Ndum[k]=0;
 Titre=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>    for (k=1; k<=7; k++) ncodemax[k]=0;
 Total number of observations=%d <br>  
 Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>    for (j=1; j<=(cptcovn+2*cptcovprod); j++) {
 <hr  size=\"2\" color=\"#EC5E5E\">      for (i=1; i<=imx; i++) { /*reads the data file to get the maximum 
 <li>Outputs files<br><br>\n                                 modality*/ 
         - Observed prevalence in each state: <a href=\"p%s\">p%s</a> <br>\n        ij=(int)(covar[Tvar[j]][i]); /* ij is the modality of this individual*/
 - Estimated parameters and the covariance matrix: <a href=\"%s\">%s</a> <br>        Ndum[ij]++; /*store the modality */
         - Stationary prevalence in each state: <a href=\"pl%s\">pl%s</a> <br>        /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/
         - Transition probabilities: <a href=\"pij%s\">pij%s</a><br>        if (ij > cptcode) cptcode=ij; /* getting the maximum of covariable 
         - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>                                         Tvar[j]. If V=sex and male is 0 and 
         - Life expectancies by age and initial health status: <a href=\"e%s\">e%s</a> <br>                                         female is 1, then  cptcode=1.*/
         - Variances of life expectancies by age and initial health status: <a href=\"v%s\">v%s</a><br>      }
         - Health expectancies with their variances: <a href=\"t%s\">t%s</a> <br>  
         - Standard deviation of stationary prevalences: <a href=\"vpl%s\">vpl%s</a> <br><br>",title,datafile,firstpass,lastpass,stepm, weightopt,model,imx,jmin,jmax,jmean,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres);      for (i=0; i<=cptcode; i++) {
         if(Ndum[i]!=0) ncodemax[j]++; /* Nomber of modalities of the j th covariates. In fact ncodemax[j]=2 (dichotom. variables) but it can be more */
  fprintf(fichtm," <li>Graphs</li><p>");      }
   
  m=cptcoveff;      ij=1; 
  if (cptcovn < 1) {m=1;ncodemax[1]=1;}      for (i=1; i<=ncodemax[j]; i++) {
         for (k=0; k<= maxncov; k++) {
  j1=0;          if (Ndum[k] != 0) {
  for(k1=1; k1<=m;k1++){            nbcode[Tvar[j]][ij]=k; 
    for(i1=1; i1<=ncodemax[k1];i1++){            /* store the modality in an array. k is a modality. If we have model=V1+V1*sex then: nbcode[1][1]=0 ; nbcode[1][2]=1; nbcode[2][1]=0 ; nbcode[2][2]=1; */
        j1++;            
        if (cptcovn > 0) {            ij++;
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");          }
          for (cpt=1; cpt<=cptcoveff;cpt++)          if (ij > ncodemax[j]) break; 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[j1][cpt]]);        }  
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");      } 
        }    }  
        fprintf(fichtm,"<br>- Probabilities: pe%s%d.gif<br>  
 <img src=\"pe%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);       for (k=0; k< maxncov; k++) Ndum[k]=0;
        for(cpt=1; cpt<nlstate;cpt++){  
          fprintf(fichtm,"<br>- Prevalence of disability : p%s%d%d.gif<br>   for (i=1; i<=ncovmodel-2; i++) { 
 <img src=\"p%s%d%d.gif\">",strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);     /* Listing of all covariables in statement model to see if some covariates appear twice. For example, V1 appears twice in V1+V1*V2.*/
        }     ij=Tvar[i];
     for(cpt=1; cpt<=nlstate;cpt++) {     Ndum[ij]++;
        fprintf(fichtm,"<br>- Observed and stationary prevalence (with confident   }
 interval) in state (%d): v%s%d%d.gif <br>  
 <img src=\"v%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);     ij=1;
      }   for (i=1; i<= maxncov; i++) {
      for(cpt=1; cpt<=nlstate;cpt++) {     if((Ndum[i]!=0) && (i<=ncovcol)){
         fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): exp%s%d%d.gif <br>       Tvaraff[ij]=i; /*For printing */
 <img src=\"exp%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);       ij++;
      }     }
      fprintf(fichtm,"\n<br>- Total life expectancy by age and   }
 health expectancies in states (1) and (2): e%s%d.gif<br>   
 <img src=\"e%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);   cptcoveff=ij-1; /*Number of simple covariates*/
 fprintf(fichtm,"\n</body>");  }
    }  
  }  /*********** Health Expectancies ****************/
 fclose(fichtm);  
   void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int cij, int estepm,char strstart[] )
   /*--------------- Prevalence limit --------------*/  
    {
   strcpy(filerespl,"pl");    /* Health expectancies, no variances */
   strcat(filerespl,fileres);    int i, j, nhstepm, hstepm, h, nstepm, k, cptj, cptj2, i2, j2;
   if((ficrespl=fopen(filerespl,"w"))==NULL) {    double age, agelim, hf;
     printf("Problem with Prev limit resultfile: %s\n", filerespl);goto end;    double ***p3mat;
   }    double eip;
   printf("Computing prevalence limit: result on file '%s' \n", filerespl);  
   fprintf(ficrespl,"#Prevalence limit\n");    pstamp(ficreseij);
   fprintf(ficrespl,"#Age ");    fprintf(ficreseij,"# (a) Life expectancies by health status at initial age and (b) health expectancies by health status at initial age\n");
   for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);    fprintf(ficreseij,"# Age");
   fprintf(ficrespl,"\n");    for(i=1; i<=nlstate;i++){
        for(j=1; j<=nlstate;j++){
   prlim=matrix(1,nlstate,1,nlstate);        fprintf(ficreseij," e%1d%1d ",i,j);
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */      }
   oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */      fprintf(ficreseij," e%1d. ",i);
   newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    }
   savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    fprintf(ficreseij,"\n");
   oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */  
   k=0;    
   agebase=agemin;    if(estepm < stepm){
   agelim=agemax;      printf ("Problem %d lower than %d\n",estepm, stepm);
   ftolpl=1.e-10;    }
   i1=cptcoveff;    else  hstepm=estepm;   
   if (cptcovn < 1){i1=1;}    /* We compute the life expectancy from trapezoids spaced every estepm months
      * This is mainly to measure the difference between two models: for example
   for(cptcov=1;cptcov<=i1;cptcov++){     * if stepm=24 months pijx are given only every 2 years and by summing them
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){     * we are calculating an estimate of the Life Expectancy assuming a linear 
         k=k+1;     * progression in between and thus overestimating or underestimating according
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/     * to the curvature of the survival function. If, for the same date, we 
         fprintf(ficrespl,"\n#******");     * estimate the model with stepm=1 month, we can keep estepm to 24 months
         for(j=1;j<=cptcoveff;j++)     * to compare the new estimate of Life expectancy with the same linear 
           fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);     * hypothesis. A more precise result, taking into account a more precise
         fprintf(ficrespl,"******\n");     * curvature will be obtained if estepm is as small as stepm. */
          
         for (age=agebase; age<=agelim; age++){    /* For example we decided to compute the life expectancy with the smallest unit */
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
           fprintf(ficrespl,"%.0f",age );       nhstepm is the number of hstepm from age to agelim 
           for(i=1; i<=nlstate;i++)       nstepm is the number of stepm from age to agelin. 
           fprintf(ficrespl," %.5f", prlim[i][i]);       Look at hpijx to understand the reason of that which relies in memory size
           fprintf(ficrespl,"\n");       and note for a fixed period like estepm months */
         }    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
       }       survival function given by stepm (the optimization length). Unfortunately it
     }       means that if the survival funtion is printed only each two years of age and if
   fclose(ficrespl);       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
   /*------------- h Pij x at various ages ------------*/       results. So we changed our mind and took the option of the best precision.
      */
   strcpy(filerespij,"pij");  strcat(filerespij,fileres);    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
   if((ficrespij=fopen(filerespij,"w"))==NULL) {  
     printf("Problem with Pij resultfile: %s\n", filerespij);goto end;    agelim=AGESUP;
   }    /* nhstepm age range expressed in number of stepm */
   printf("Computing pij: result on file '%s' \n", filerespij);    nstepm=(int) rint((agelim-age)*YEARM/stepm); 
      /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
   stepsize=(int) (stepm+YEARM-1)/YEARM;    /* if (stepm >= YEARM) hstepm=1;*/
   if (stepm<=24) stepsize=2;    nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   agelim=AGESUP;  
   hstepm=stepsize*YEARM; /* Every year of age */    for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
   hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */      /* Computed by stepm unit matrices, product of hstepm matrices, stored
           in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
   k=0;      
   for(cptcov=1;cptcov<=i1;cptcov++){      hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, cij);  
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){      
       k=k+1;      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
         fprintf(ficrespij,"\n#****** ");      
         for(j=1;j<=cptcoveff;j++)      printf("%d|",(int)age);fflush(stdout);
           fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);      fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
         fprintf(ficrespij,"******\n");      
              /* Computing expectancies */
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */      for(i=1; i<=nlstate;i++)
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */        for(j=1; j<=nlstate;j++)
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);            eij[i][j][(int)age] += (p3mat[i][j][h]+p3mat[i][j][h+1])/2.0*hf;
           oldm=oldms;savm=savms;            
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);              /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
           fprintf(ficrespij,"# Age");  
           for(i=1; i<=nlstate;i++)          }
             for(j=1; j<=nlstate+ndeath;j++)  
               fprintf(ficrespij," %1d-%1d",i,j);      fprintf(ficreseij,"%3.0f",age );
           fprintf(ficrespij,"\n");      for(i=1; i<=nlstate;i++){
           for (h=0; h<=nhstepm; h++){        eip=0;
             fprintf(ficrespij,"%d %.0f %.0f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );        for(j=1; j<=nlstate;j++){
             for(i=1; i<=nlstate;i++)          eip +=eij[i][j][(int)age];
               for(j=1; j<=nlstate+ndeath;j++)          fprintf(ficreseij,"%9.4f", eij[i][j][(int)age] );
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);        }
             fprintf(ficrespij,"\n");        fprintf(ficreseij,"%9.4f", eip );
           }      }
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);      fprintf(ficreseij,"\n");
           fprintf(ficrespij,"\n");      
         }    }
     }    free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   }    printf("\n");
     fprintf(ficlog,"\n");
   fclose(ficrespij);    
   }
   /*---------- Health expectancies and variances ------------*/  
   void cvevsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int cij, int estepm,double delti[],double **matcov,char strstart[] )
   strcpy(filerest,"t");  
   strcat(filerest,fileres);  {
   if((ficrest=fopen(filerest,"w"))==NULL) {    /* Covariances of health expectancies eij and of total life expectancies according
     printf("Problem with total LE resultfile: %s\n", filerest);goto end;     to initial status i, ei. .
   }    */
   printf("Computing Total LEs with variances: file '%s' \n", filerest);    int i, j, nhstepm, hstepm, h, nstepm, k, cptj, cptj2, i2, j2, ij, ji;
     double age, agelim, hf;
     double ***p3matp, ***p3matm, ***varhe;
   strcpy(filerese,"e");    double **dnewm,**doldm;
   strcat(filerese,fileres);    double *xp, *xm;
   if((ficreseij=fopen(filerese,"w"))==NULL) {    double **gp, **gm;
     printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);    double ***gradg, ***trgradg;
   }    int theta;
   printf("Computing Health Expectancies: result on file '%s' \n", filerese);  
     double eip, vip;
  strcpy(fileresv,"v");  
   strcat(fileresv,fileres);    varhe=ma3x(1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int) fage);
   if((ficresvij=fopen(fileresv,"w"))==NULL) {    xp=vector(1,npar);
     printf("Problem with variance resultfile: %s\n", fileresv);exit(0);    xm=vector(1,npar);
   }    dnewm=matrix(1,nlstate*nlstate,1,npar);
   printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);    doldm=matrix(1,nlstate*nlstate,1,nlstate*nlstate);
     
   k=0;    pstamp(ficresstdeij);
   for(cptcov=1;cptcov<=i1;cptcov++){    fprintf(ficresstdeij,"# Health expectancies with standard errors\n");
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){    fprintf(ficresstdeij,"# Age");
       k=k+1;    for(i=1; i<=nlstate;i++){
       fprintf(ficrest,"\n#****** ");      for(j=1; j<=nlstate;j++)
       for(j=1;j<=cptcoveff;j++)        fprintf(ficresstdeij," e%1d%1d (SE)",i,j);
         fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);      fprintf(ficresstdeij," e%1d. ",i);
       fprintf(ficrest,"******\n");    }
     fprintf(ficresstdeij,"\n");
       fprintf(ficreseij,"\n#****** ");  
       for(j=1;j<=cptcoveff;j++)    pstamp(ficrescveij);
         fprintf(ficreseij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);    fprintf(ficrescveij,"# Subdiagonal matrix of covariances of health expectancies by age: cov(eij,ekl)\n");
       fprintf(ficreseij,"******\n");    fprintf(ficrescveij,"# Age");
     for(i=1; i<=nlstate;i++)
       fprintf(ficresvij,"\n#****** ");      for(j=1; j<=nlstate;j++){
       for(j=1;j<=cptcoveff;j++)        cptj= (j-1)*nlstate+i;
         fprintf(ficresvij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);        for(i2=1; i2<=nlstate;i2++)
       fprintf(ficresvij,"******\n");          for(j2=1; j2<=nlstate;j2++){
             cptj2= (j2-1)*nlstate+i2;
       eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);            if(cptj2 <= cptj)
       oldm=oldms;savm=savms;              fprintf(ficrescveij,"  %1d%1d,%1d%1d",i,j,i2,j2);
       evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k);            }
       vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);      }
       oldm=oldms;savm=savms;    fprintf(ficrescveij,"\n");
       varevsij(fileres, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);    
          if(estepm < stepm){
       fprintf(ficrest,"#Total LEs with variances: e.. (std) ");      printf ("Problem %d lower than %d\n",estepm, stepm);
       for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);    }
       fprintf(ficrest,"\n");    else  hstepm=estepm;   
            /* We compute the life expectancy from trapezoids spaced every estepm months
       hf=1;     * This is mainly to measure the difference between two models: for example
       if (stepm >= YEARM) hf=stepm/YEARM;     * if stepm=24 months pijx are given only every 2 years and by summing them
       epj=vector(1,nlstate+1);     * we are calculating an estimate of the Life Expectancy assuming a linear 
       for(age=bage; age <=fage ;age++){     * progression in between and thus overestimating or underestimating according
         prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);     * to the curvature of the survival function. If, for the same date, we 
         fprintf(ficrest," %.0f",age);     * estimate the model with stepm=1 month, we can keep estepm to 24 months
         for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){     * to compare the new estimate of Life expectancy with the same linear 
           for(i=1, epj[j]=0.;i <=nlstate;i++) {     * hypothesis. A more precise result, taking into account a more precise
             epj[j] += prlim[i][i]*hf*eij[i][j][(int)age];     * curvature will be obtained if estepm is as small as stepm. */
           }  
           epj[nlstate+1] +=epj[j];    /* For example we decided to compute the life expectancy with the smallest unit */
         }    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
         for(i=1, vepp=0.;i <=nlstate;i++)       nhstepm is the number of hstepm from age to agelim 
           for(j=1;j <=nlstate;j++)       nstepm is the number of stepm from age to agelin. 
             vepp += vareij[i][j][(int)age];       Look at hpijx to understand the reason of that which relies in memory size
         fprintf(ficrest," %.2f (%.2f)", epj[nlstate+1],hf*sqrt(vepp));       and note for a fixed period like estepm months */
         for(j=1;j <=nlstate;j++){    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
           fprintf(ficrest," %.2f (%.2f)", epj[j],hf*sqrt(vareij[j][j][(int)age]));       survival function given by stepm (the optimization length). Unfortunately it
         }       means that if the survival funtion is printed only each two years of age and if
         fprintf(ficrest,"\n");       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
       }       results. So we changed our mind and took the option of the best precision.
     }    */
   }    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
          
  fclose(ficreseij);    /* If stepm=6 months */
  fclose(ficresvij);    /* nhstepm age range expressed in number of stepm */
   fclose(ficrest);    agelim=AGESUP;
   fclose(ficpar);    nstepm=(int) rint((agelim-age)*YEARM/stepm); 
   free_vector(epj,1,nlstate+1);    /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
   /*  scanf("%d ",i); */    /* if (stepm >= YEARM) hstepm=1;*/
     nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
   /*------- Variance limit prevalence------*/      
     p3matp=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
 strcpy(fileresvpl,"vpl");    p3matm=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   strcat(fileresvpl,fileres);    gradg=ma3x(0,nhstepm,1,npar,1,nlstate*nlstate);
   if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {    trgradg =ma3x(0,nhstepm,1,nlstate*nlstate,1,npar);
     printf("Problem with variance prev lim resultfile: %s\n", fileresvpl);    gp=matrix(0,nhstepm,1,nlstate*nlstate);
     exit(0);    gm=matrix(0,nhstepm,1,nlstate*nlstate);
   }  
   printf("Computing Variance-covariance of Prevalence limit: file '%s' \n", fileresvpl);    for (age=bage; age<=fage; age ++){ 
   
  k=0;      /* Computed by stepm unit matrices, product of hstepm matrices, stored
  for(cptcov=1;cptcov<=i1;cptcov++){         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
    for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){   
      k=k+1;      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
      fprintf(ficresvpl,"\n#****** ");  
      for(j=1;j<=cptcoveff;j++)      /* Computing  Variances of health expectancies */
        fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);      /* Gradient is computed with plus gp and minus gm. Code is duplicated in order to
      fprintf(ficresvpl,"******\n");         decrease memory allocation */
            for(theta=1; theta <=npar; theta++){
      varpl=matrix(1,nlstate,(int) bage, (int) fage);        for(i=1; i<=npar; i++){ 
      oldm=oldms;savm=savms;          xp[i] = x[i] + (i==theta ?delti[theta]:0);
      varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);          xm[i] = x[i] - (i==theta ?delti[theta]:0);
    }        }
  }        hpxij(p3matp,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, cij);  
         hpxij(p3matm,nhstepm,age,hstepm,xm,nlstate,stepm,oldm,savm, cij);  
   fclose(ficresvpl);    
         for(j=1; j<= nlstate; j++){
   /*---------- End : free ----------------*/          for(i=1; i<=nlstate; i++){
   free_matrix(varpl,1,nlstate,(int) bage, (int)fage);            for(h=0; h<=nhstepm-1; h++){
                gp[h][(j-1)*nlstate + i] = (p3matp[i][j][h]+p3matp[i][j][h+1])/2.;
   free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);              gm[h][(j-1)*nlstate + i] = (p3matm[i][j][h]+p3matm[i][j][h+1])/2.;
   free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);            }
            }
          }
   free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);       
   free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);        for(ij=1; ij<= nlstate*nlstate; ij++)
   free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);          for(h=0; h<=nhstepm-1; h++){
   free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);            gradg[h][theta][ij]= (gp[h][ij]-gm[h][ij])/2./delti[theta];
            }
   free_matrix(matcov,1,npar,1,npar);      }/* End theta */
   free_vector(delti,1,npar);      
        
   free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);      for(h=0; h<=nhstepm-1; h++)
         for(j=1; j<=nlstate*nlstate;j++)
   printf("End of Imach\n");          for(theta=1; theta <=npar; theta++)
   /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */            trgradg[h][j][theta]=gradg[h][theta][j];
        
   /* printf("Total time was %d Sec. %d uSec.\n", end_time.tv_sec -start_time.tv_sec, end_time.tv_usec -start_time.tv_usec);*/  
   /*printf("Total time was %d uSec.\n", total_usecs);*/       for(ij=1;ij<=nlstate*nlstate;ij++)
   /*------ End -----------*/        for(ji=1;ji<=nlstate*nlstate;ji++)
           varhe[ij][ji][(int)age] =0.;
  end:  
 #ifdef windows       printf("%d|",(int)age);fflush(stdout);
  chdir(pathcd);       fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
 #endif       for(h=0;h<=nhstepm-1;h++){
  /*system("wgnuplot graph.plt");*/        for(k=0;k<=nhstepm-1;k++){
  /*system("../gp37mgw/wgnuplot graph.plt");*/          matprod2(dnewm,trgradg[h],1,nlstate*nlstate,1,npar,1,npar,matcov);
  /*system("cd ../gp37mgw");*/          matprod2(doldm,dnewm,1,nlstate*nlstate,1,npar,1,nlstate*nlstate,gradg[k]);
  system("..\\gp37mgw\\wgnuplot graph.plt");          for(ij=1;ij<=nlstate*nlstate;ij++)
             for(ji=1;ji<=nlstate*nlstate;ji++)
 #ifdef windows              varhe[ij][ji][(int)age] += doldm[ij][ji]*hf*hf;
   while (z[0] != 'q') {        }
     chdir(pathcd);      }
     printf("\nType e to edit output files, c to start again, and q for exiting: ");      /* Computing expectancies */
     scanf("%s",z);      hpxij(p3matm,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, cij);  
     if (z[0] == 'c') system("./imach");      for(i=1; i<=nlstate;i++)
     else if (z[0] == 'e') {        for(j=1; j<=nlstate;j++)
       chdir(path);          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
       system(optionfilehtm);            eij[i][j][(int)age] += (p3matm[i][j][h]+p3matm[i][j][h+1])/2.0*hf;
     }            
     else if (z[0] == 'q') exit(0);            /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
   }  
 #endif          }
 }  
       fprintf(ficresstdeij,"%3.0f",age );
       for(i=1; i<=nlstate;i++){
         eip=0.;
         vip=0.;
         for(j=1; j<=nlstate;j++){
           eip += eij[i][j][(int)age];
           for(k=1; k<=nlstate;k++) /* Sum on j and k of cov(eij,eik) */
             vip += varhe[(j-1)*nlstate+i][(k-1)*nlstate+i][(int)age];
           fprintf(ficresstdeij," %9.4f (%.4f)", eij[i][j][(int)age], sqrt(varhe[(j-1)*nlstate+i][(j-1)*nlstate+i][(int)age]) );
         }
         fprintf(ficresstdeij," %9.4f (%.4f)", eip, sqrt(vip));
       }
       fprintf(ficresstdeij,"\n");
   
       fprintf(ficrescveij,"%3.0f",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           cptj= (j-1)*nlstate+i;
           for(i2=1; i2<=nlstate;i2++)
             for(j2=1; j2<=nlstate;j2++){
               cptj2= (j2-1)*nlstate+i2;
               if(cptj2 <= cptj)
                 fprintf(ficrescveij," %.4f", varhe[cptj][cptj2][(int)age]);
             }
         }
       fprintf(ficrescveij,"\n");
      
     }
     free_matrix(gm,0,nhstepm,1,nlstate*nlstate);
     free_matrix(gp,0,nhstepm,1,nlstate*nlstate);
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate*nlstate);
     free_ma3x(trgradg,0,nhstepm,1,nlstate*nlstate,1,npar);
     free_ma3x(p3matm,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     free_ma3x(p3matp,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     printf("\n");
     fprintf(ficlog,"\n");
   
     free_vector(xm,1,npar);
     free_vector(xp,1,npar);
     free_matrix(dnewm,1,nlstate*nlstate,1,npar);
     free_matrix(doldm,1,nlstate*nlstate,1,nlstate*nlstate);
     free_ma3x(varhe,1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int)fage);
   }
   
   /************ Variance ******************/
   void varevsij(char optionfilefiname[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, int estepm, int cptcov, int cptcod, int popbased, int mobilav, char strstart[])
   {
     /* Variance of health expectancies */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/
     /* double **newm;*/
     double **dnewm,**doldm;
     double **dnewmp,**doldmp;
     int i, j, nhstepm, hstepm, h, nstepm ;
     int k, cptcode;
     double *xp;
     double **gp, **gm;  /* for var eij */
     double ***gradg, ***trgradg; /*for var eij */
     double **gradgp, **trgradgp; /* for var p point j */
     double *gpp, *gmp; /* for var p point j */
     double **varppt; /* for var p point j nlstate to nlstate+ndeath */
     double ***p3mat;
     double age,agelim, hf;
     double ***mobaverage;
     int theta;
     char digit[4];
     char digitp[25];
   
     char fileresprobmorprev[FILENAMELENGTH];
   
     if(popbased==1){
       if(mobilav!=0)
         strcpy(digitp,"-populbased-mobilav-");
       else strcpy(digitp,"-populbased-nomobil-");
     }
     else 
       strcpy(digitp,"-stablbased-");
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     strcpy(fileresprobmorprev,"prmorprev"); 
     sprintf(digit,"%-d",ij);
     /*printf("DIGIT=%s, ij=%d ijr=%-d|\n",digit, ij,ij);*/
     strcat(fileresprobmorprev,digit); /* Tvar to be done */
     strcat(fileresprobmorprev,digitp); /* Popbased or not, mobilav or not */
     strcat(fileresprobmorprev,fileres);
     if((ficresprobmorprev=fopen(fileresprobmorprev,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobmorprev);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobmorprev);
     }
     printf("Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
    
     fprintf(ficlog,"Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
     pstamp(ficresprobmorprev);
     fprintf(ficresprobmorprev,"# probabilities of dying before estepm=%d months for people of exact age and weighted probabilities w1*p1j+w2*p2j+... stand dev in()\n",estepm);
     fprintf(ficresprobmorprev,"# Age cov=%-d",ij);
     for(j=nlstate+1; j<=(nlstate+ndeath);j++){
       fprintf(ficresprobmorprev," p.%-d SE",j);
       for(i=1; i<=nlstate;i++)
         fprintf(ficresprobmorprev," w%1d p%-d%-d",i,i,j);
     }  
     fprintf(ficresprobmorprev,"\n");
     fprintf(ficgp,"\n# Routine varevsij");
     /* fprintf(fichtm, "#Local time at start: %s", strstart);*/
     fprintf(fichtm,"\n<li><h4> Computing probabilities of dying over estepm months as a weighted average (i.e global mortality independent of initial healh state)</h4></li>\n");
     fprintf(fichtm,"\n<br>%s  <br>\n",digitp);
   /*   } */
     varppt = matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     pstamp(ficresvij);
     fprintf(ficresvij,"# Variance and covariance of health expectancies e.j \n#  (weighted average of eij where weights are ");
     if(popbased==1)
       fprintf(ficresvij,"the age specific prevalence observed in the population i.e cross-sectionally\n in each health state (popbased=1)");
     else
       fprintf(ficresvij,"the age specific period (stable) prevalences in each health state \n");
     fprintf(ficresvij,"# Age");
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=nlstate;j++)
         fprintf(ficresvij," Cov(e.%1d, e.%1d)",i,j);
     fprintf(ficresvij,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     dnewmp= matrix(nlstate+1,nlstate+ndeath,1,npar);
     doldmp= matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
   
     gradgp=matrix(1,npar,nlstate+1,nlstate+ndeath);
     gpp=vector(nlstate+1,nlstate+ndeath);
     gmp=vector(nlstate+1,nlstate+ndeath);
     trgradgp =matrix(nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
     /* For example we decided to compute the life expectancy with the smallest unit */
     /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
        nhstepm is the number of hstepm from age to agelim 
        nstepm is the number of stepm from age to agelin. 
        Look at hpijx to understand the reason of that which relies in memory size
        and note for a fixed period like k years */
     /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
        means that if the survival funtion is printed every two years of age and if
        you sum them up and add 1 year (area under the trapezoids) you won't get the same 
        results. So we changed our mind and took the option of the best precision.
     */
     hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       gradg=ma3x(0,nhstepm,1,npar,1,nlstate);
       gp=matrix(0,nhstepm,1,nlstate);
       gm=matrix(0,nhstepm,1,nlstate);
   
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient x + delta*/
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
   
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
     
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gp[h][j]=0.;i<=nlstate;i++)
               gp[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gpp[j]=0.; i<= nlstate; i++)
             gpp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(i=1; i<=npar; i++) /* Computes gradient x - delta */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
    
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
   
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gm[h][j]=0.;i<=nlstate;i++)
               gm[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gmp[j]=0.; i<= nlstate; i++)
            gmp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(j=1; j<= nlstate; j++) /* vareij */
           for(h=0; h<=nhstepm; h++){
             gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
           }
   
         for(j=nlstate+1; j<= nlstate+ndeath; j++){ /* var mu */
           gradgp[theta][j]= (gpp[j]-gmp[j])/2./delti[theta];
         }
   
       } /* End theta */
   
       trgradg =ma3x(0,nhstepm,1,nlstate,1,npar); /* veij */
   
       for(h=0; h<=nhstepm; h++) /* veij */
         for(j=1; j<=nlstate;j++)
           for(theta=1; theta <=npar; theta++)
             trgradg[h][j][theta]=gradg[h][theta][j];
   
       for(j=nlstate+1; j<=nlstate+ndeath;j++) /* mu */
         for(theta=1; theta <=npar; theta++)
           trgradgp[j][theta]=gradgp[theta][j];
     
   
       hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
       for(i=1;i<=nlstate;i++)
         for(j=1;j<=nlstate;j++)
           vareij[i][j][(int)age] =0.;
   
       for(h=0;h<=nhstepm;h++){
         for(k=0;k<=nhstepm;k++){
           matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);
           matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);
           for(i=1;i<=nlstate;i++)
             for(j=1;j<=nlstate;j++)
               vareij[i][j][(int)age] += doldm[i][j]*hf*hf;
         }
       }
     
       /* pptj */
       matprod2(dnewmp,trgradgp,nlstate+1,nlstate+ndeath,1,npar,1,npar,matcov);
       matprod2(doldmp,dnewmp,nlstate+1,nlstate+ndeath,1,npar,nlstate+1,nlstate+ndeath,gradgp);
       for(j=nlstate+1;j<=nlstate+ndeath;j++)
         for(i=nlstate+1;i<=nlstate+ndeath;i++)
           varppt[j][i]=doldmp[j][i];
       /* end ppptj */
       /*  x centered again */
       hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm,savm, ij);  
       prevalim(prlim,nlstate,x,age,oldm,savm,ftolpl,ij);
    
       if (popbased==1) {
         if(mobilav ==0){
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=probs[(int)age][i][ij];
         }else{ /* mobilav */ 
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=mobaverage[(int)age][i][ij];
         }
       }
                
       /* This for computing probability of death (h=1 means
          computed over hstepm (estepm) matrices product = hstepm*stepm months) 
          as a weighted average of prlim.
       */
       for(j=nlstate+1;j<=nlstate+ndeath;j++){
         for(i=1,gmp[j]=0.;i<= nlstate; i++) 
           gmp[j] += prlim[i][i]*p3mat[i][j][1]; 
       }    
       /* end probability of death */
   
       fprintf(ficresprobmorprev,"%3d %d ",(int) age, ij);
       for(j=nlstate+1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprobmorprev," %11.3e %11.3e",gmp[j], sqrt(varppt[j][j]));
         for(i=1; i<=nlstate;i++){
           fprintf(ficresprobmorprev," %11.3e %11.3e ",prlim[i][i],p3mat[i][j][1]);
         }
       } 
       fprintf(ficresprobmorprev,"\n");
   
       fprintf(ficresvij,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           fprintf(ficresvij," %.4f", vareij[i][j][(int)age]);
         }
       fprintf(ficresvij,"\n");
       free_matrix(gp,0,nhstepm,1,nlstate);
       free_matrix(gm,0,nhstepm,1,nlstate);
       free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);
       free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);
       free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     } /* End age */
     free_vector(gpp,nlstate+1,nlstate+ndeath);
     free_vector(gmp,nlstate+1,nlstate+ndeath);
     free_matrix(gradgp,1,npar,nlstate+1,nlstate+ndeath);
     free_matrix(trgradgp,nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     fprintf(ficgp,"\nset noparametric;set nolabel; set ter png small;set size 0.65, 0.65");
     /* for(j=nlstate+1; j<= nlstate+ndeath; j++){ *//* Only the first actually */
     fprintf(ficgp,"\n set log y; set nolog x;set xlabel \"Age\"; set ylabel \"Force of mortality (year-1)\";");
   /*   fprintf(ficgp,"\n plot \"%s\"  u 1:($3*%6.3f) not w l 1 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)*%6.3f) t \"95\%% interval\" w l 2 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)*%6.3f) not w l 2 ",fileresprobmorprev,YEARM/estepm); */
     fprintf(ficgp,"\n plot \"%s\"  u 1:($3) not w l 1 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)) t \"95\%% interval\" w l 2 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)) not w l 2 ",subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> File (multiple files are possible if covariates are present): <A href=\"%s\">%s</a>\n",subdirf(fileresprobmorprev),subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months. <br> <img src=\"%s%s.png\"> <br>\n", estepm,subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
     /*  fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months and then divided by estepm and multiplied by %.0f in order to have the probability to die over a year <br> <img src=\"varmuptjgr%s%s.png\"> <br>\n", stepm,YEARM,digitp,digit);
   */
   /*   fprintf(ficgp,"\nset out \"varmuptjgr%s%s%s.png\";replot;",digitp,optionfilefiname,digit); */
     fprintf(ficgp,"\nset out \"%s%s.png\";replot;\n",subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,nlstate);
     free_matrix(dnewm,1,nlstate,1,npar);
     free_matrix(doldmp,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     free_matrix(dnewmp,nlstate+1,nlstate+ndeath,1,npar);
     free_matrix(varppt,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficresprobmorprev);
     fflush(ficgp);
     fflush(fichtm); 
   }  /* end varevsij */
   
   /************ Variance of prevlim ******************/
   void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, char strstart[])
   {
     /* Variance of prevalence limit */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/
     double **newm;
     double **dnewm,**doldm;
     int i, j, nhstepm, hstepm;
     int k, cptcode;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double age,agelim;
     int theta;
     
     pstamp(ficresvpl);
     fprintf(ficresvpl,"# Standard deviation of period (stable) prevalences \n");
     fprintf(ficresvpl,"# Age");
     for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %1d-%1d",i,i);
     fprintf(ficresvpl,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     
     hstepm=1*YEARM; /* Every year of age */
     hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       if (stepm >= YEARM) hstepm=1;
       nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
       gradg=matrix(1,npar,1,nlstate);
       gp=vector(1,nlstate);
       gm=vector(1,nlstate);
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient */
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gp[i] = prlim[i][i];
       
         for(i=1; i<=npar; i++) /* Computes gradient */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gm[i] = prlim[i][i];
   
         for(i=1;i<=nlstate;i++)
           gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];
       } /* End theta */
   
       trgradg =matrix(1,nlstate,1,npar);
   
       for(j=1; j<=nlstate;j++)
         for(theta=1; theta <=npar; theta++)
           trgradg[j][theta]=gradg[theta][j];
   
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] =0.;
       matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);
       matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */
   
       fprintf(ficresvpl,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));
       fprintf(ficresvpl,"\n");
       free_vector(gp,1,nlstate);
       free_vector(gm,1,nlstate);
       free_matrix(gradg,1,npar,1,nlstate);
       free_matrix(trgradg,1,nlstate,1,npar);
     } /* End age */
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,npar);
     free_matrix(dnewm,1,nlstate,1,nlstate);
   
   }
   
   /************ Variance of one-step probabilities  ******************/
   void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[])
   {
     int i, j=0,  i1, k1, l1, t, tj;
     int k2, l2, j1,  z1;
     int k=0,l, cptcode;
     int first=1, first1;
     double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp;
     double **dnewm,**doldm;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double **mu;
     double age,agelim, cov[NCOVMAX];
     double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */
     int theta;
     char fileresprob[FILENAMELENGTH];
     char fileresprobcov[FILENAMELENGTH];
     char fileresprobcor[FILENAMELENGTH];
   
     double ***varpij;
   
     strcpy(fileresprob,"prob"); 
     strcat(fileresprob,fileres);
     if((ficresprob=fopen(fileresprob,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprob);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob);
     }
     strcpy(fileresprobcov,"probcov"); 
     strcat(fileresprobcov,fileres);
     if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcov);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov);
     }
     strcpy(fileresprobcor,"probcor"); 
     strcat(fileresprobcor,fileres);
     if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcor);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor);
     }
     printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     pstamp(ficresprob);
     fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n");
     fprintf(ficresprob,"# Age");
     pstamp(ficresprobcov);
     fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n");
     fprintf(ficresprobcov,"# Age");
     pstamp(ficresprobcor);
     fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n");
     fprintf(ficresprobcor,"# Age");
   
   
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprob," p%1d-%1d (SE)",i,j);
         fprintf(ficresprobcov," p%1d-%1d ",i,j);
         fprintf(ficresprobcor," p%1d-%1d ",i,j);
       }  
    /* fprintf(ficresprob,"\n");
     fprintf(ficresprobcov,"\n");
     fprintf(ficresprobcor,"\n");
    */
    xp=vector(1,npar);
     dnewm=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
     doldm=matrix(1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     mu=matrix(1,(nlstate)*(nlstate+ndeath), (int) bage, (int)fage);
     varpij=ma3x(1,nlstate*(nlstate+ndeath),1,nlstate*(nlstate+ndeath),(int) bage, (int) fage);
     first=1;
     fprintf(ficgp,"\n# Routine varprob");
     fprintf(fichtm,"\n<li><h4> Computing and drawing one step probabilities with their confidence intervals</h4></li>\n");
     fprintf(fichtm,"\n");
   
     fprintf(fichtm,"\n<li><h4> <a href=\"%s\">Matrix of variance-covariance of pairs of step probabilities (drawings)</a></h4></li>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\n<h4>Matrix of variance-covariance of pairs of step probabilities</h4>\n\
     file %s<br>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (p<inf>ij</inf>, p<inf>kl</inf>) are estimated\
   and drawn. It helps understanding how is the covariance between two incidences.\
    They are expressed in year<sup>-1</sup> in order to be less dependent of stepm.<br>\n");
     fprintf(fichtmcov,"\n<br> Contour plot corresponding to x'cov<sup>-1</sup>x = 4 (where x is the column vector (pij,pkl)) are drawn. \
   It can be understood this way: if pij and pkl where uncorrelated the (2x2) matrix of covariance \
   would have been (1/(var pij), 0 , 0, 1/(var pkl)), and the confidence interval would be 2 \
   standard deviations wide on each axis. <br>\
    Now, if both incidences are correlated (usual case) we diagonalised the inverse of the covariance matrix\
    and made the appropriate rotation to look at the uncorrelated principal directions.<br>\
   To be simple, these graphs help to understand the significativity of each parameter in relation to a second other one.<br> \n");
   
     cov[1]=1;
     tj=cptcoveff;
     if (cptcovn<1) {tj=1;ncodemax[1]=1;}
     j1=0;
     for(t=1; t<=tj;t++){
       for(i1=1; i1<=ncodemax[t];i1++){ 
         j1++;
         if  (cptcovn>0) {
           fprintf(ficresprob, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprob, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprob, "**********\n#\n");
           fprintf(ficresprobcov, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcov, "**********\n#\n");
           
           fprintf(ficgp, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficgp, " V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficgp, "**********\n#\n");
           
           
           fprintf(fichtmcov, "\n<hr  size=\"2\" color=\"#EC5E5E\">********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(fichtmcov, "**********\n<hr size=\"2\" color=\"#EC5E5E\">");
           
           fprintf(ficresprobcor, "\n#********** Variable ");    
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcor, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcor, "**********\n#");    
         }
         
         for (age=bage; age<=fage; age ++){ 
           cov[2]=age;
           for (k=1; k<=cptcovn;k++) {
             cov[2+k]=nbcode[Tvar[k]][codtab[j1][Tvar[k]]];
           }
           for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
           for (k=1; k<=cptcovprod;k++)
             cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
           
           gradg=matrix(1,npar,1,(nlstate)*(nlstate+ndeath));
           trgradg=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
           gp=vector(1,(nlstate)*(nlstate+ndeath));
           gm=vector(1,(nlstate)*(nlstate+ndeath));
       
           for(theta=1; theta <=npar; theta++){
             for(i=1; i<=npar; i++)
               xp[i] = x[i] + (i==theta ?delti[theta]:(double)0);
             
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             
             k=0;
             for(i=1; i<= (nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gp[k]=pmmij[i][j];
               }
             }
             
             for(i=1; i<=npar; i++)
               xp[i] = x[i] - (i==theta ?delti[theta]:(double)0);
       
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             k=0;
             for(i=1; i<=(nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gm[k]=pmmij[i][j];
               }
             }
        
             for(i=1; i<= (nlstate)*(nlstate+ndeath); i++) 
               gradg[theta][i]=(gp[i]-gm[i])/(double)2./delti[theta];  
           }
   
           for(j=1; j<=(nlstate)*(nlstate+ndeath);j++)
             for(theta=1; theta <=npar; theta++)
               trgradg[j][theta]=gradg[theta][j];
           
           matprod2(dnewm,trgradg,1,(nlstate)*(nlstate+ndeath),1,npar,1,npar,matcov); 
           matprod2(doldm,dnewm,1,(nlstate)*(nlstate+ndeath),1,npar,1,(nlstate)*(nlstate+ndeath),gradg);
           free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
           free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
   
           pmij(pmmij,cov,ncovmodel,x,nlstate);
           
           k=0;
           for(i=1; i<=(nlstate); i++){
             for(j=1; j<=(nlstate+ndeath);j++){
               k=k+1;
               mu[k][(int) age]=pmmij[i][j];
             }
           }
           for(i=1;i<=(nlstate)*(nlstate+ndeath);i++)
             for(j=1;j<=(nlstate)*(nlstate+ndeath);j++)
               varpij[i][j][(int)age] = doldm[i][j];
   
           /*printf("\n%d ",(int)age);
             for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             fprintf(ficlog,"%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             }*/
   
           fprintf(ficresprob,"\n%d ",(int)age);
           fprintf(ficresprobcov,"\n%d ",(int)age);
           fprintf(ficresprobcor,"\n%d ",(int)age);
   
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++)
             fprintf(ficresprob,"%11.3e (%11.3e) ",mu[i][(int) age],sqrt(varpij[i][i][(int)age]));
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             fprintf(ficresprobcov,"%11.3e ",mu[i][(int) age]);
             fprintf(ficresprobcor,"%11.3e ",mu[i][(int) age]);
           }
           i=0;
           for (k=1; k<=(nlstate);k++){
             for (l=1; l<=(nlstate+ndeath);l++){ 
               i=i++;
               fprintf(ficresprobcov,"\n%d %d-%d",(int)age,k,l);
               fprintf(ficresprobcor,"\n%d %d-%d",(int)age,k,l);
               for (j=1; j<=i;j++){
                 fprintf(ficresprobcov," %11.3e",varpij[i][j][(int)age]);
                 fprintf(ficresprobcor," %11.3e",varpij[i][j][(int) age]/sqrt(varpij[i][i][(int) age])/sqrt(varpij[j][j][(int)age]));
               }
             }
           }/* end of loop for state */
         } /* end of loop for age */
   
         /* Confidence intervalle of pij  */
         /*
           fprintf(ficgp,"\nset noparametric;unset label");
           fprintf(ficgp,"\nset log y;unset log x; set xlabel \"Age\";set ylabel \"probability (year-1)\"");
           fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
           fprintf(fichtm,"\n<br>Probability with  confidence intervals expressed in year<sup>-1</sup> :<a href=\"pijgr%s.png\">pijgr%s.png</A>, ",optionfilefiname,optionfilefiname);
           fprintf(fichtm,"\n<br><img src=\"pijgr%s.png\"> ",optionfilefiname);
           fprintf(ficgp,"\nset out \"pijgr%s.png\"",optionfilefiname);
           fprintf(ficgp,"\nplot \"%s\" every :::%d::%d u 1:2 \"\%%lf",k1,k2,xfilevarprob);
         */
   
         /* Drawing ellipsoids of confidence of two variables p(k1-l1,k2-l2)*/
         first1=1;
         for (k2=1; k2<=(nlstate);k2++){
           for (l2=1; l2<=(nlstate+ndeath);l2++){ 
             if(l2==k2) continue;
             j=(k2-1)*(nlstate+ndeath)+l2;
             for (k1=1; k1<=(nlstate);k1++){
               for (l1=1; l1<=(nlstate+ndeath);l1++){ 
                 if(l1==k1) continue;
                 i=(k1-1)*(nlstate+ndeath)+l1;
                 if(i<=j) continue;
                 for (age=bage; age<=fage; age ++){ 
                   if ((int)age %5==0){
                     v1=varpij[i][i][(int)age]/stepm*YEARM/stepm*YEARM;
                     v2=varpij[j][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     cv12=varpij[i][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     mu1=mu[i][(int) age]/stepm*YEARM ;
                     mu2=mu[j][(int) age]/stepm*YEARM;
                     c12=cv12/sqrt(v1*v2);
                     /* Computing eigen value of matrix of covariance */
                     lc1=((v1+v2)+sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     lc2=((v1+v2)-sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     /* Eigen vectors */
                     v11=(1./sqrt(1+(v1-lc1)*(v1-lc1)/cv12/cv12));
                     /*v21=sqrt(1.-v11*v11); *//* error */
                     v21=(lc1-v1)/cv12*v11;
                     v12=-v21;
                     v22=v11;
                     tnalp=v21/v11;
                     if(first1==1){
                       first1=0;
                       printf("%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tang %.3f\nOthers in log...\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     }
                     fprintf(ficlog,"%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tan %.3f\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     /*printf(fignu*/
                     /* mu1+ v11*lc1*cost + v12*lc2*sin(t) */
                     /* mu2+ v21*lc1*cost + v22*lc2*sin(t) */
                     if(first==1){
                       first=0;
                       fprintf(ficgp,"\nset parametric;unset label");
                       fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2);
                       fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
                       fprintf(fichtmcov,"\n<br>Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year<sup>-1</sup>\
    :<a href=\"%s%d%1d%1d-%1d%1d.png\">\
   %s%d%1d%1d-%1d%1d.png</A>, ",k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br><img src=\"%s%d%1d%1d-%1d%1d.png\"> ",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br> Correlation at age %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\"",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }else{
                       first=0;
                       fprintf(fichtmcov," %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }/* if first */
                   } /* age mod 5 */
                 } /* end loop age */
                 fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\";replot;",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                 first=1;
               } /*l12 */
             } /* k12 */
           } /*l1 */
         }/* k1 */
       } /* loop covariates */
     }
     free_ma3x(varpij,1,nlstate,1,nlstate+ndeath,(int) bage, (int)fage);
     free_matrix(mu,1,(nlstate+ndeath)*(nlstate+ndeath),(int) bage, (int)fage);
     free_matrix(doldm,1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     free_matrix(dnewm,1,(nlstate)*(nlstate+ndeath),1,npar);
     free_vector(xp,1,npar);
     fclose(ficresprob);
     fclose(ficresprobcov);
     fclose(ficresprobcor);
     fflush(ficgp);
     fflush(fichtmcov);
   }
   
   
   /******************* Printing html file ***********/
   void printinghtml(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,int jmin, int jmax, double jmeanint,char rfileres[],\
                     int popforecast, int estepm ,\
                     double jprev1, double mprev1,double anprev1, \
                     double jprev2, double mprev2,double anprev2){
     int jj1, k1, i1, cpt;
   
      fprintf(fichtm,"<ul><li><a href='#firstorder'>Result files (first order: no variance)</a>\n \
      <li><a href='#secondorder'>Result files (second order (variance)</a>\n \
   </ul>");
      fprintf(fichtm,"<ul><li><h4><a name='firstorder'>Result files (first order: no variance)</a></h4>\n \
    - Observed prevalence in each state (during the period defined between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf): <a href=\"%s\">%s</a> <br>\n ",
              jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,subdirf2(fileres,"p"),subdirf2(fileres,"p"));
      fprintf(fichtm,"\
    - Estimated transition probabilities over %d (stepm) months: <a href=\"%s\">%s</a><br>\n ",
              stepm,subdirf2(fileres,"pij"),subdirf2(fileres,"pij"));
      fprintf(fichtm,"\
    - Period (stable) prevalence in each health state: <a href=\"%s\">%s</a> <br>\n",
              subdirf2(fileres,"pl"),subdirf2(fileres,"pl"));
      fprintf(fichtm,"\
    - (a) Life expectancies by health status at initial age, (b) health expectancies by health status at initial age:  ei., eij . If one or more covariate are included, specific tables for each value of the covariate are output in sequences within the same file (estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"e"),subdirf2(fileres,"e"));
   
   
   fprintf(fichtm," \n<ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        /* Pij */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i, %d (stepm) months before: <a href=\"%s%d1.png\">%s%d1.png</a><br> \
   <img src=\"%s%d1.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1);     
        /* Quasi-incidences */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i %d (stepm) months\
    before but expressed in per year i.e. quasi incidences if stepm is small and probabilities too: <a href=\"%s%d2.png\">%s%d2.png</a><br> \
   <img src=\"%s%d2.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1); 
          /* Period (stable) prevalence in each health state */
          for(cpt=1; cpt<nlstate;cpt++){
            fprintf(fichtm,"<br>- Period (stable) prevalence in each health state : <a href=\"%s%d%d.png\">%s%d%d.png</a><br> \
   <img src=\"%s%d%d.png\">",subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1);
          }
        for(cpt=1; cpt<=nlstate;cpt++) {
           fprintf(fichtm,"\n<br>- Life expectancy by health state (%d) at initial age and its decomposition into health expectancies : <a href=\"%s%d%d.png\">%s%d%d.png</a> <br> \
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1);
        }
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
   
   
    fprintf(fichtm,"\
   \n<br><li><h4> <a name='secondorder'>Result files (second order: variances)</a></h4>\n\
    - Parameter file with estimated parameters and covariance matrix: <a href=\"%s\">%s</a> <br>\n", rfileres,rfileres);
   
    fprintf(fichtm," - Variance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"prob"),subdirf2(fileres,"prob"));
    fprintf(fichtm,"\
    - Variance-covariance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcov"),subdirf2(fileres,"probcov"));
   
    fprintf(fichtm,"\
    - Correlation matrix of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcor"),subdirf2(fileres,"probcor"));
    fprintf(fichtm,"\
    - Variances and covariances of health expectancies by age and <b>initial health status</b> (cov(e<sup>ij</sup>,e<sup>kl</sup>)(estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"cve"),subdirf2(fileres,"cve"));
    fprintf(fichtm,"\
    - (a) Health expectancies by health status at initial age (e<sup>ij</sup>) and standard errors (in parentheses) (b) life expectancies and standard errors (e<sup>i.</sup>=e<sup>i1</sup>+e<sup>i2</sup>+...)(estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"stde"),subdirf2(fileres,"stde"));
    fprintf(fichtm,"\
    - Variances and covariances of health expectancies by age. Status (i) based health expectancies (in state j), eij are weighted by the period prevalences in each state i (if popbased=1, an additional computation is done using the cross-sectional prevalences (i.e population based) (estepm=%d months): <a href=\"%s\">%s</a><br>\n",
            estepm, subdirf2(fileres,"v"),subdirf2(fileres,"v"));
    fprintf(fichtm,"\
    - Total life expectancy and total health expectancies to be spent in each health state e<sup>.j</sup> with their standard errors: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"t"),subdirf2(fileres,"t"));
    fprintf(fichtm,"\
    - Standard deviation of period (stable) prevalences: <a href=\"%s\">%s</a> <br>\n",\
            subdirf2(fileres,"vpl"),subdirf2(fileres,"vpl"));
   
   /*  if(popforecast==1) fprintf(fichtm,"\n */
   /*  - Prevalences forecasting: <a href=\"f%s\">f%s</a> <br>\n */
   /*  - Population forecasting (if popforecast=1): <a href=\"pop%s\">pop%s</a> <br>\n */
   /*      <br>",fileres,fileres,fileres,fileres); */
   /*  else  */
   /*    fprintf(fichtm,"\n No population forecast: popforecast = %d (instead of 1) or stepm = %d (instead of 1) or model=%s (instead of .)<br><br></li>\n",popforecast, stepm, model); */
    fflush(fichtm);
    fprintf(fichtm," <ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        for(cpt=1; cpt<=nlstate;cpt++) {
          fprintf(fichtm,"<br>- Observed (cross-sectional) and period (incidence based) \
   prevalence (with 95%% confidence interval) in state (%d): %s%d%d.png <br>\
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"v"),cpt,jj1,subdirf2(optionfilefiname,"v"),cpt,jj1);  
        }
        fprintf(fichtm,"\n<br>- Total life expectancy by age and \
   health expectancies in states (1) and (2): %s%d.png<br>\
   <img src=\"%s%d.png\">",subdirf2(optionfilefiname,"e"),jj1,subdirf2(optionfilefiname,"e"),jj1);
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
    fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplot(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   /*   if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */
   /*     printf("Problem with file %s",optionfilegnuplot); */
   /*     fprintf(ficlog,"Problem with file %s",optionfilegnuplot); */
   /*   } */
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
     m=pow(2,cptcoveff);
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
    /* 1eme*/
     for (cpt=1; cpt<= nlstate ; cpt ++) {
      for (k1=1; k1<= m ; k1 ++) {
        fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"v"),cpt,k1);
        fprintf(ficgp,"\n#set out \"v%s%d%d.png\" \n",optionfilefiname,cpt,k1);
        fprintf(ficgp,"set xlabel \"Age\" \n\
   set ylabel \"Probability\" \n\
   set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:2 \"\%%lf",ageminpar,fage,subdirf2(fileres,"vpl"),k1-1,k1-1);
   
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }
        fprintf(ficgp,"\" t\"Period (stable) prevalence\" w l 0,\"%s\" every :::%d::%d u 1:($2+1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1);
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        } 
        fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"%s\" every :::%d::%d u 1:($2-1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1); 
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }  
        fprintf(ficgp,"\" t\"\" w l 1,\"%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",subdirf2(fileres,"p"),k1-1,k1-1,2+4*(cpt-1));
      }
     }
     /*2 eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       fprintf(ficgp,"\nset out \"%s%d.png\" \n",subdirf2(optionfilefiname,"e"),k1);
       fprintf(ficgp,"set ylabel \"Years\" \nset ter png small\nset size 0.65,0.65\nplot [%.f:%.f] ",ageminpar,fage);
       
       for (i=1; i<= nlstate+1 ; i ++) {
         k=2*i;
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:2 \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");
         else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         fprintf(ficgp,"\" t\"\" w l 0,");
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");
         else fprintf(ficgp,"\" t\"\" w l 0,");
       }
     }
     
     /*3eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<= nlstate ; cpt ++) {
         /*       k=2+nlstate*(2*cpt-2); */
         k=2+(nlstate+1)*(cpt-1);
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"exp"),cpt,k1);
         fprintf(ficgp,"set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",ageminpar,fage,subdirf2(fileres,"e"),k1-1,k1-1,k,cpt);
         /*fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d-2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d+2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           
         */
         for (i=1; i< nlstate ; i ++) {
           fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+i,cpt,i+1);
           /*      fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+2*i,cpt,i+1);*/
           
         } 
         fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d.\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+nlstate,cpt);
       }
     }
     
     /* CV preval stable (period) */
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<=nlstate ; cpt ++) {
         k=3;
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"p"),cpt,k1);
         fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\
   set ter png small\nset size 0.65,0.65\n\
   unset log y\n\
   plot [%.f:%.f] \"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",ageminpar,agemaxpar,subdirf2(fileres,"pij"),k1,k+cpt+1,k+1);
         
         for (i=1; i< nlstate ; i ++)
           fprintf(ficgp,"+$%d",k+i+1);
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);
         
         l=3+(nlstate+ndeath)*cpt;
         fprintf(ficgp,",\"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",subdirf2(fileres,"pij"),k1,l+cpt+1,l+1);
         for (i=1; i< nlstate ; i ++) {
           l=3+(nlstate+ndeath)*cpt;
           fprintf(ficgp,"+$%d",l+i+1);
         }
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);   
       } 
     }  
     
     /* proba elementaires */
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           for(j=1; j <=ncovmodel; j++){
             fprintf(ficgp,"p%d=%f ",jk,p[jk]);
             jk++; 
             fprintf(ficgp,"\n");
           }
         }
       }
      }
   
      for(ng=1; ng<=2;ng++){ /* Number of graphics: first is probabilities second is incidence per year*/
        for(jk=1; jk <=m; jk++) {
          fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"pe"),jk,ng); 
          if (ng==2)
            fprintf(ficgp,"\nset ylabel \"Quasi-incidence per year\"\n");
          else
            fprintf(ficgp,"\nset title \"Probability\"\n");
          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65\nset log y\nplot  [%.f:%.f] ",ageminpar,agemaxpar);
          i=1;
          for(k2=1; k2<=nlstate; k2++) {
            k3=i;
            for(k=1; k<=(nlstate+ndeath); k++) {
              if (k != k2){
                if(ng==2)
                  fprintf(ficgp," %f*exp(p%d+p%d*x",YEARM/stepm,i,i+1);
                else
                  fprintf(ficgp," exp(p%d+p%d*x",i,i+1);
                ij=1;
                for(j=3; j <=ncovmodel; j++) {
                  if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                    fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                    ij++;
                  }
                  else
                    fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                }
                fprintf(ficgp,")/(1");
                
                for(k1=1; k1 <=nlstate; k1++){   
                  fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);
                  ij=1;
                  for(j=3; j <=ncovmodel; j++){
                    if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                      fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                      ij++;
                    }
                    else
                      fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                  }
                  fprintf(ficgp,")");
                }
                fprintf(ficgp,") t \"p%d%d\" ", k2,k);
                if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");
                i=i+ncovmodel;
              }
            } /* end k */
          } /* end k2 */
        } /* end jk */
      } /* end ng */
      fflush(ficgp); 
   }  /* end gnuplot */
   
   
   /*************** Moving average **************/
   int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav){
   
     int i, cpt, cptcod;
     int modcovmax =1;
     int mobilavrange, mob;
     double age;
   
     modcovmax=2*cptcoveff;/* Max number of modalities. We suppose 
                              a covariate has 2 modalities */
     if (cptcovn<1) modcovmax=1; /* At least 1 pass */
   
     if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){
       if(mobilav==1) mobilavrange=5; /* default */
       else mobilavrange=mobilav;
       for (age=bage; age<=fage; age++)
         for (i=1; i<=nlstate;i++)
           for (cptcod=1;cptcod<=modcovmax;cptcod++)
             mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod];
       /* We keep the original values on the extreme ages bage, fage and for 
          fage+1 and bage-1 we use a 3 terms moving average; for fage+2 bage+2
          we use a 5 terms etc. until the borders are no more concerned. 
       */ 
       for (mob=3;mob <=mobilavrange;mob=mob+2){
         for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){
           for (i=1; i<=nlstate;i++){
             for (cptcod=1;cptcod<=modcovmax;cptcod++){
               mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod];
                 for (cpt=1;cpt<=(mob-1)/2;cpt++){
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod];
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod];
                 }
               mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob;
             }
           }
         }/* end age */
       }/* end mob */
     }else return -1;
     return 0;
   }/* End movingaverage */
   
   
   /************** Forecasting ******************/
   prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){
     /* proj1, year, month, day of starting projection 
        agemin, agemax range of age
        dateprev1 dateprev2 range of dates during which prevalence is computed
        anproj2 year of en of projection (same day and month as proj1).
     */
     int yearp, stepsize, hstepm, nhstepm, j, k, c, cptcod, i, h, i1;
     int *popage;
     double agec; /* generic age */
     double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean;
     double *popeffectif,*popcount;
     double ***p3mat;
     double ***mobaverage;
     char fileresf[FILENAMELENGTH];
   
     agelim=AGESUP;
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
    
     strcpy(fileresf,"f"); 
     strcat(fileresf,fileres);
     if((ficresf=fopen(fileresf,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", fileresf);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", fileresf);
     }
     printf("Computing forecasting: result on file '%s' \n", fileresf);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", fileresf);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
   
     hstepm=hstepm/stepm; 
     yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp  and
                                  fractional in yp1 */
     anprojmean=yp;
     yp2=modf((yp1*12),&yp);
     mprojmean=yp;
     yp1=modf((yp2*30.5),&yp);
     jprojmean=yp;
     if(jprojmean==0) jprojmean=1;
     if(mprojmean==0) jprojmean=1;
   
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
     
     fprintf(ficresf,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); 
     
     fprintf(ficresf,"#****** Routine prevforecast **\n");
   
   /*            if (h==(int)(YEARM*yearp)){ */
     for(cptcov=1, k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficresf,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficresf," V%d=%d, hpijx=probability over h years, hp.jx is weighted by observed prev ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficresf,"******\n");
         fprintf(ficresf,"# Covariate valuofcovar yearproj age");
         for(j=1; j<=nlstate+ndeath;j++){ 
           for(i=1; i<=nlstate;i++)              
             fprintf(ficresf," p%d%d",i,j);
           fprintf(ficresf," p.%d",j);
         }
         for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { 
           fprintf(ficresf,"\n");
           fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp);   
   
           for (agec=fage; agec>=(ageminpar-1); agec--){ 
             nhstepm=(int) rint((agelim-agec)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h*hstepm/YEARM*stepm ==yearp) {
                 fprintf(ficresf,"\n");
                 for(j=1;j<=cptcoveff;j++) 
                   fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
                 fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 ppij=0.;
                 for(i=1; i<=nlstate;i++) {
                   if (mobilav==1) 
                     ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod];
                   else {
                     ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod];
                   }
                   if (h*hstepm/YEARM*stepm== yearp) {
                     fprintf(ficresf," %.3f", p3mat[i][j][h]);
                   }
                 } /* end i */
                 if (h*hstepm/YEARM*stepm==yearp) {
                   fprintf(ficresf," %.3f", ppij);
                 }
               }/* end j */
             } /* end h */
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           } /* end agec */
         } /* end yearp */
       } /* end cptcod */
     } /* end  cptcov */
          
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     fclose(ficresf);
   }
   
   /************** Forecasting *****not tested NB*************/
   populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){
     
     int cpt, stepsize, hstepm, nhstepm, j,k,c, cptcod, i,h;
     int *popage;
     double calagedatem, agelim, kk1, kk2;
     double *popeffectif,*popcount;
     double ***p3mat,***tabpop,***tabpopprev;
     double ***mobaverage;
     char filerespop[FILENAMELENGTH];
   
     tabpop= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     tabpopprev= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     agelim=AGESUP;
     calagedatem=(anpyram+mpyram/12.+jpyram/365.-dateintmean)*YEARM;
     
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     
     
     strcpy(filerespop,"pop"); 
     strcat(filerespop,fileres);
     if((ficrespop=fopen(filerespop,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", filerespop);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", filerespop);
     }
     printf("Computing forecasting: result on file '%s' \n", filerespop);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", filerespop);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     
     agelim=AGESUP;
     
     hstepm=1;
     hstepm=hstepm/stepm; 
     
     if (popforecast==1) {
       if((ficpop=fopen(popfile,"r"))==NULL) {
         printf("Problem with population file : %s\n",popfile);exit(0);
         fprintf(ficlog,"Problem with population file : %s\n",popfile);exit(0);
       } 
       popage=ivector(0,AGESUP);
       popeffectif=vector(0,AGESUP);
       popcount=vector(0,AGESUP);
       
       i=1;   
       while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF) i=i+1;
      
       imx=i;
       for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];
     }
   
     for(cptcov=1,k=0;cptcov<=i2;cptcov++){
      for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficrespop,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespop," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespop,"******\n");
         fprintf(ficrespop,"# Age");
         for(j=1; j<=nlstate+ndeath;j++) fprintf(ficrespop," P.%d",j);
         if (popforecast==1)  fprintf(ficrespop," [Population]");
         
         for (cpt=0; cpt<=0;cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficrespop,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   if (mobilav==1) 
                     kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb+1][i][cptcod];
                   else {
                     kk1=kk1+p3mat[i][j][h]*probs[(int)(agedeb+1)][i][cptcod];
                   }
                 }
                 if (h==(int)(calagedatem+12*cpt)){
                   tabpop[(int)(agedeb)][j][cptcod]=kk1;
                     /*fprintf(ficrespop," %.3f", kk1);
                       if (popforecast==1) fprintf(ficrespop," [%.f]", kk1*popeffectif[(int)agedeb+1]);*/
                 }
               }
               for(i=1; i<=nlstate;i++){
                 kk1=0.;
                   for(j=1; j<=nlstate;j++){
                     kk1= kk1+tabpop[(int)(agedeb)][j][cptcod]; 
                   }
                     tabpopprev[(int)(agedeb)][i][cptcod]=tabpop[(int)(agedeb)][i][cptcod]/kk1*popeffectif[(int)(agedeb+(calagedatem+12*cpt)*hstepm/YEARM*stepm-1)];
               }
   
               if (h==(int)(calagedatem+12*cpt)) for(j=1; j<=nlstate;j++) 
                 fprintf(ficrespop," %15.2f",tabpopprev[(int)(agedeb+1)][j][cptcod]);
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
    
     /******/
   
         for (cpt=1; cpt<=(anpyram1-anpyram);cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficresf,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   kk1=kk1+p3mat[i][j][h]*tabpopprev[(int)agedeb+1][i][cptcod];    
                 }
                 if (h==(int)(calagedatem+12*cpt)) fprintf(ficresf," %15.2f", kk1);        
               }
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
      } 
     }
    
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     if (popforecast==1) {
       free_ivector(popage,0,AGESUP);
       free_vector(popeffectif,0,AGESUP);
       free_vector(popcount,0,AGESUP);
     }
     free_ma3x(tabpop,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(tabpopprev,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficrespop);
   } /* End of popforecast */
   
   int fileappend(FILE *fichier, char *optionfich)
   {
     if((fichier=fopen(optionfich,"a"))==NULL) {
       printf("Problem with file: %s\n", optionfich);
       fprintf(ficlog,"Problem with file: %s\n", optionfich);
       return (0);
     }
     fflush(fichier);
     return (1);
   }
   
   
   /**************** function prwizard **********************/
   void prwizard(int ncovmodel, int nlstate, int ndeath,  char model[], FILE *ficparo)
   {
   
     /* Wizard to print covariance matrix template */
   
     char ca[32], cb[32], cc[32];
     int i,j, k, l, li, lj, lk, ll, jj, npar, itimes;
     int numlinepar;
   
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficparo,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         /*ca[0]= k+'a'-1;ca[1]='\0';*/
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           /*        printf(" %lf",param[i][j][k]); */
           /*        fprintf(ficparo," %lf",param[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficparo,"# Scales (for hessian or gradient estimation)\n");
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/ 
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         fprintf(ficparo,"%1d%1d",i,j);
         printf("%1d%1d",i,j);
         fflush(stdout);
         for(k=1; k<=ncovmodel;k++){
           /*      printf(" %le",delti3[i][j][k]); */
           /*      fprintf(ficparo," %le",delti3[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Covariance matrix\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
     fflush(stdout);
     fprintf(ficparo,"# Covariance matrix\n");
     /* # 121 Var(a12)\n\ */
     /* # 122 Cov(b12,a12) Var(b12)\n\ */
     /* #   ...\n\ */
     /* # 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n" */
     
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               printf("#%1d%1d%d",i,j,k);
               fprintf(ficparo,"#%1d%1d%d",i,j,k);
             }else{
               printf("%1d%1d%d",i,j,k);
               fprintf(ficparo,"%1d%1d%d",i,j,k);
               /*  printf(" %.5le",matcov[i][j]); */
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficparo," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }else{
                       if(itimes==1){
                         printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficparo," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             printf("\n");
             fprintf(ficparo,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
   } /* end of prwizard */
   /******************* Gompertz Likelihood ******************************/
   double gompertz(double x[])
   { 
     double A,B,L=0.0,sump=0.,num=0.;
     int i,n=0; /* n is the size of the sample */
   
     for (i=0;i<=imx-1 ; i++) {
       sump=sump+weight[i];
       /*    sump=sump+1;*/
       num=num+1;
     }
    
    
     /* for (i=0; i<=imx; i++) 
        if (wav[i]>0) printf("i=%d ageex=%lf agecens=%lf agedc=%lf cens=%d %d\n" ,i,ageexmed[i],agecens[i],agedc[i],cens[i],wav[i]);*/
   
     for (i=1;i<=imx ; i++)
       {
         if (cens[i] == 1 && wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agecens[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)));
         
         if (cens[i] == 0 && wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agedc[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)))
                +log(x[1]/YEARM)+x[2]*(agedc[i]-agegomp)+log(YEARM);  
         
         /*if (wav[i] > 1 && agecens[i] > 15) {*/ /* ??? */
         if (wav[i] > 1 ) { /* ??? */
           L=L+A*weight[i];
           /*      printf("\ni=%d A=%f L=%lf x[1]=%lf x[2]=%lf ageex=%lf agecens=%lf cens=%d agedc=%lf weight=%lf\n",i,A,L,x[1],x[2],ageexmed[i]*12,agecens[i]*12,cens[i],agedc[i]*12,weight[i]);*/
         }
       }
   
    /*printf("x1=%2.9f x2=%2.9f x3=%2.9f L=%f\n",x[1],x[2],x[3],L);*/
    
     return -2*L*num/sump;
   }
   
   /******************* Printing html file ***********/
   void printinghtmlmort(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,  double p[],double **matcov,double agemortsup){
     int i,k;
   
     fprintf(fichtm,"<ul><li><h4>Result files </h4>\n Force of mortality. Parameters of the Gompertz fit (with confidence interval in brackets):<br>");
     fprintf(fichtm,"  mu(age) =%lf*exp(%lf*(age-%d)) per year<br><br>",p[1],p[2],agegomp);
     for (i=1;i<=2;i++) 
       fprintf(fichtm," p[%d] = %lf [%f ; %f]<br>\n",i,p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
     fprintf(fichtm,"<br><br><img src=\"graphmort.png\">");
     fprintf(fichtm,"</ul>");
   
   fprintf(fichtm,"<ul><li><h4>Life table</h4>\n <br>");
   
    fprintf(fichtm,"\nAge   l<inf>x</inf>     q<inf>x</inf> d(x,x+1)    L<inf>x</inf>     T<inf>x</inf>     e<infx</inf><br>");
   
    for (k=agegomp;k<(agemortsup-2);k++) 
      fprintf(fichtm,"%d %.0lf %lf %.0lf %.0lf %.0lf %lf<br>\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
    
     fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplotmort(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
   
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
     fprintf(ficgp,"set out \"graphmort.png\"\n "); 
     fprintf(ficgp,"set xlabel \"Age\"\n set ylabel \"Force of mortality (per year)\" \n "); 
     fprintf(ficgp, "set ter png small\n set log y\n"); 
     fprintf(ficgp, "set size 0.65,0.65\n");
     fprintf(ficgp,"plot [%d:100] %lf*exp(%lf*(x-%d))",agegomp,p[1],p[2],agegomp);
   
   } 
   
   
   
   
   
   /***********************************************/
   /**************** Main Program *****************/
   /***********************************************/
   
   int main(int argc, char *argv[])
   {
     int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav);
     int i,j, k, n=MAXN,iter,m,size=100,cptcode, cptcod;
     int linei, month, year,iout;
     int jj, ll, li, lj, lk, imk;
     int numlinepar=0; /* Current linenumber of parameter file */
     int itimes;
     int NDIM=2;
   
     char ca[32], cb[32], cc[32];
     char dummy[]="                         ";
     /*  FILE *fichtm; *//* Html File */
     /* FILE *ficgp;*/ /*Gnuplot File */
     struct stat info;
     double agedeb, agefin,hf;
     double ageminpar=1.e20,agemin=1.e20, agemaxpar=-1.e20, agemax=-1.e20;
   
     double fret;
     double **xi,tmp,delta;
   
     double dum; /* Dummy variable */
     double ***p3mat;
     double ***mobaverage;
     int *indx;
     char line[MAXLINE], linepar[MAXLINE];
     char path[MAXLINE],pathc[MAXLINE],pathcd[MAXLINE],pathtot[MAXLINE],model[MAXLINE];
     char pathr[MAXLINE], pathimach[MAXLINE]; 
     char **bp, *tok, *val; /* pathtot */
     int firstobs=1, lastobs=10;
     int sdeb, sfin; /* Status at beginning and end */
     int c,  h , cpt,l;
     int ju,jl, mi;
     int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;
     int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,*tab; 
     int mobilavproj=0 , prevfcast=0 ; /* moving average of prev, If prevfcast=1 prevalence projection */
     int mobilav=0,popforecast=0;
     int hstepm, nhstepm;
     int agemortsup;
     float  sumlpop=0.;
     double jprev1=1, mprev1=1,anprev1=2000,jprev2=1, mprev2=1,anprev2=2000;
     double jpyram=1, mpyram=1,anpyram=2000,jpyram1=1, mpyram1=1,anpyram1=2000;
   
     double bage, fage, age, agelim, agebase;
     double ftolpl=FTOL;
     double **prlim;
     double *severity;
     double ***param; /* Matrix of parameters */
     double  *p;
     double **matcov; /* Matrix of covariance */
     double ***delti3; /* Scale */
     double *delti; /* Scale */
     double ***eij, ***vareij;
     double **varpl; /* Variances of prevalence limits by age */
     double *epj, vepp;
     double kk1, kk2;
     double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000;
     double **ximort;
     char *alph[]={"a","a","b","c","d","e"}, str[4];
     int *dcwave;
   
     char z[1]="c", occ;
   
     char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];
     char  *strt, strtend[80];
     char *stratrunc;
     int lstra;
   
     long total_usecs;
    
   /*   setlocale (LC_ALL, ""); */
   /*   bindtextdomain (PACKAGE, LOCALEDIR); */
   /*   textdomain (PACKAGE); */
   /*   setlocale (LC_CTYPE, ""); */
   /*   setlocale (LC_MESSAGES, ""); */
   
     /*   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */
     (void) gettimeofday(&start_time,&tzp);
     curr_time=start_time;
     tm = *localtime(&start_time.tv_sec);
     tmg = *gmtime(&start_time.tv_sec);
     strcpy(strstart,asctime(&tm));
   
   /*  printf("Localtime (at start)=%s",strstart); */
   /*  tp.tv_sec = tp.tv_sec +86400; */
   /*  tm = *localtime(&start_time.tv_sec); */
   /*   tmg.tm_year=tmg.tm_year +dsign*dyear; */
   /*   tmg.tm_mon=tmg.tm_mon +dsign*dmonth; */
   /*   tmg.tm_hour=tmg.tm_hour + 1; */
   /*   tp.tv_sec = mktime(&tmg); */
   /*   strt=asctime(&tmg); */
   /*   printf("Time(after) =%s",strstart);  */
   /*  (void) time (&time_value);
   *  printf("time=%d,t-=%d\n",time_value,time_value-86400);
   *  tm = *localtime(&time_value);
   *  strstart=asctime(&tm);
   *  printf("tim_value=%d,asctime=%s\n",time_value,strstart); 
   */
   
     nberr=0; /* Number of errors and warnings */
     nbwarn=0;
     getcwd(pathcd, size);
   
     printf("\n%s\n%s",version,fullversion);
     if(argc <=1){
       printf("\nEnter the parameter file name: ");
       fgets(pathr,FILENAMELENGTH,stdin);
       i=strlen(pathr);
       if(pathr[i-1]=='\n')
         pathr[i-1]='\0';
      for (tok = pathr; tok != NULL; ){
         printf("Pathr |%s|\n",pathr);
         while ((val = strsep(&tok, "\"" )) != NULL && *val == '\0');
         printf("val= |%s| pathr=%s\n",val,pathr);
         strcpy (pathtot, val);
         if(pathr[0] == '\0') break; /* Dirty */
       }
     }
     else{
       strcpy(pathtot,argv[1]);
     }
     /*if(getcwd(pathcd, MAXLINE)!= NULL)printf ("Error pathcd\n");*/
     /*cygwin_split_path(pathtot,path,optionfile);
       printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/
     /* cutv(path,optionfile,pathtot,'\\');*/
   
     /* Split argv[0], imach program to get pathimach */
     printf("\nargv[0]=%s argv[1]=%s, \n",argv[0],argv[1]);
     split(argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
     printf("\nargv[0]=%s pathimach=%s, \noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
    /*   strcpy(pathimach,argv[0]); */
     /* Split argv[1]=pathtot, parameter file name to get path, optionfile, extension and name */
     split(pathtot,path,optionfile,optionfilext,optionfilefiname);
     printf("\npathtot=%s,\npath=%s,\noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
     chdir(path); /* Can be a relative path */
     if(getcwd(pathcd,MAXLINE) > 0) /* So pathcd is the full path */
       printf("Current directory %s!\n",pathcd);
     strcpy(command,"mkdir ");
     strcat(command,optionfilefiname);
     if((outcmd=system(command)) != 0){
       printf("Problem creating directory or it already exists %s%s, err=%d\n",path,optionfilefiname,outcmd);
       /* fprintf(ficlog,"Problem creating directory %s%s\n",path,optionfilefiname); */
       /* fclose(ficlog); */
   /*     exit(1); */
     }
   /*   if((imk=mkdir(optionfilefiname))<0){ */
   /*     perror("mkdir"); */
   /*   } */
   
     /*-------- arguments in the command line --------*/
   
     /* Log file */
     strcat(filelog, optionfilefiname);
     strcat(filelog,".log");    /* */
     if((ficlog=fopen(filelog,"w"))==NULL)    {
       printf("Problem with logfile %s\n",filelog);
       goto end;
     }
     fprintf(ficlog,"Log filename:%s\n",filelog);
     fprintf(ficlog,"\n%s\n%s",version,fullversion);
     fprintf(ficlog,"\nEnter the parameter file name: \n");
     fprintf(ficlog,"pathimach=%s\npathtot=%s\n\
    path=%s \n\
    optionfile=%s\n\
    optionfilext=%s\n\
    optionfilefiname=%s\n",pathimach,pathtot,path,optionfile,optionfilext,optionfilefiname);
   
     printf("Local time (at start):%s",strstart);
     fprintf(ficlog,"Local time (at start): %s",strstart);
     fflush(ficlog);
   /*   (void) gettimeofday(&curr_time,&tzp); */
   /*   printf("Elapsed time %d\n", asc_diff_time(curr_time.tv_sec-start_time.tv_sec,tmpout)); */
   
     /* */
     strcpy(fileres,"r");
     strcat(fileres, optionfilefiname);
     strcat(fileres,".txt");    /* Other files have txt extension */
   
     /*---------arguments file --------*/
   
     if((ficpar=fopen(optionfile,"r"))==NULL)    {
       printf("Problem with optionfile %s\n",optionfile);
       fprintf(ficlog,"Problem with optionfile %s\n",optionfile);
       fflush(ficlog);
       goto end;
     }
   
   
   
     strcpy(filereso,"o");
     strcat(filereso,fileres);
     if((ficparo=fopen(filereso,"w"))==NULL) { /* opened on subdirectory */
       printf("Problem with Output resultfile: %s\n", filereso);
       fprintf(ficlog,"Problem with Output resultfile: %s\n", filereso);
       fflush(ficlog);
       goto end;
     }
   
     /* Reads comments: lines beginning with '#' */
     numlinepar=0;
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d model=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncovcol, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);
     numlinepar++;
     printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate,ndeath, maxwav, mle, weightopt,model);
     fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fprintf(ficlog,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fflush(ficlog);
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
      
     covar=matrix(0,NCOVMAX,1,n); 
     cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement*/
     if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;
   
     ncovmodel=2+cptcovn; /*Number of variables = cptcovn + intercept + age */
     nvar=ncovmodel-1; /* Suppressing age as a basic covariate */
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/
   
     delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     delti=delti3[1][1];
     /*delti=vector(1,npar); *//* Scale of each paramater (output from hesscov)*/
     if(mle==-1){ /* Print a wizard for help writing covariance matrix */
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       fclose (ficparo);
       fclose (ficlog);
       exit(0);
     }
     else if(mle==-3) {
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       matcov=matrix(1,npar,1,npar);
     }
     else{
       /* Read guess parameters */
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
       
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       for(i=1; i <=nlstate; i++){
         j=0;
         for(jj=1; jj <=nlstate+ndeath; jj++){
           if(jj==i) continue;
           j++;
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1 != i) && (j1 != j)){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           fprintf(ficparo,"%1d%1d",i1,j1);
           if(mle==1)
             printf("%1d%1d",i,j);
           fprintf(ficlog,"%1d%1d",i,j);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar," %lf",&param[i][j][k]);
             if(mle==1){
               printf(" %lf",param[i][j][k]);
               fprintf(ficlog," %lf",param[i][j][k]);
             }
             else
               fprintf(ficlog," %lf",param[i][j][k]);
             fprintf(ficparo," %lf",param[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           if(mle==1)
             printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficparo,"\n");
         }
       }  
       fflush(ficlog);
   
       p=param[1][1];
       
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
   
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath-1; j++){
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1-i)*(j1-j)!=0){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           printf("%1d%1d",i,j);
           fprintf(ficparo,"%1d%1d",i1,j1);
           fprintf(ficlog,"%1d%1d",i1,j1);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar,"%le",&delti3[i][j][k]);
             printf(" %le",delti3[i][j][k]);
             fprintf(ficparo," %le",delti3[i][j][k]);
             fprintf(ficlog," %le",delti3[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           printf("\n");
           fprintf(ficparo,"\n");
           fprintf(ficlog,"\n");
         }
       }
       fflush(ficlog);
   
       delti=delti3[1][1];
   
   
       /* free_ma3x(delti3,1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ /* Hasn't to to freed here otherwise delti is no more allocated */
     
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
     
       matcov=matrix(1,npar,1,npar);
       for(i=1; i <=npar; i++){
         fscanf(ficpar,"%s",&str);
         if(mle==1)
           printf("%s",str);
         fprintf(ficlog,"%s",str);
         fprintf(ficparo,"%s",str);
         for(j=1; j <=i; j++){
           fscanf(ficpar," %le",&matcov[i][j]);
           if(mle==1){
             printf(" %.5le",matcov[i][j]);
           }
           fprintf(ficlog," %.5le",matcov[i][j]);
           fprintf(ficparo," %.5le",matcov[i][j]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         if(mle==1)
           printf("\n");
         fprintf(ficlog,"\n");
         fprintf(ficparo,"\n");
       }
       for(i=1; i <=npar; i++)
         for(j=i+1;j<=npar;j++)
           matcov[i][j]=matcov[j][i];
       
       if(mle==1)
         printf("\n");
       fprintf(ficlog,"\n");
       
       fflush(ficlog);
       
       /*-------- Rewriting parameter file ----------*/
       strcpy(rfileres,"r");    /* "Rparameterfile */
       strcat(rfileres,optionfilefiname);    /* Parameter file first name*/
       strcat(rfileres,".");    /* */
       strcat(rfileres,optionfilext);    /* Other files have txt extension */
       if((ficres =fopen(rfileres,"w"))==NULL) {
         printf("Problem writing new parameter file: %s\n", fileres);goto end;
         fprintf(ficlog,"Problem writing new parameter file: %s\n", fileres);goto end;
       }
       fprintf(ficres,"#%s\n",version);
     }    /* End of mle != -3 */
   
     /*-------- data file ----------*/
     if((fic=fopen(datafile,"r"))==NULL)    {
       printf("Problem while opening datafile: %s\n", datafile);goto end;
       fprintf(ficlog,"Problem while opening datafile: %s\n", datafile);goto end;
     }
   
     n= lastobs;
     severity = vector(1,maxwav);
     outcome=imatrix(1,maxwav+1,1,n);
     num=lvector(1,n);
     moisnais=vector(1,n);
     annais=vector(1,n);
     moisdc=vector(1,n);
     andc=vector(1,n);
     agedc=vector(1,n);
     cod=ivector(1,n);
     weight=vector(1,n);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */
     mint=matrix(1,maxwav,1,n);
     anint=matrix(1,maxwav,1,n);
     s=imatrix(1,maxwav+1,1,n);
     tab=ivector(1,NCOVMAX);
     ncodemax=ivector(1,8);
   
     i=1;
     linei=0;
     while ((fgets(line, MAXLINE, fic) != NULL) &&((i >= firstobs) && (i <=lastobs))) {
       linei=linei+1;
       for(j=strlen(line); j>=0;j--){  /* Untabifies line */
         if(line[j] == '\t')
           line[j] = ' ';
       }
       for(j=strlen(line)-1; (line[j]==' ')||(line[j]==10)||(line[j]==13);j--){
         ;
       };
       line[j+1]=0;  /* Trims blanks at end of line */
       if(line[0]=='#'){
         fprintf(ficlog,"Comment line\n%s\n",line);
         printf("Comment line\n%s\n",line);
         continue;
       }
   
       for (j=maxwav;j>=1;j--){
         cutv(stra, strb,line,' '); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         /*        if (errno == ERANGE && (lval == LONG_MAX || lval == LONG_MIN))*/
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %d %s for individual %d, '%s'\nShould be a status of wave %d. Setting maxwav=%d might be wrong.  Exiting.\n", strb, linei,i,line,j,maxwav);
           exit(1);
         }
         s[j][i]=lval;
         
         strcpy(line,stra);
         cutv(stra, strb,line,' ');
         if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
         }
         else  if(iout=sscanf(strb,"%s.") != 0){
           month=99;
           year=9999;
         }else{
           printf("Error reading data around '%s' at line number %ld %s for individual %d, '%s'\nShould be a date of interview (mm/yyyy or .) at wave %d.  Exiting.\n",strb, linei,i, line,j);
           exit(1);
         }
         anint[j][i]= (double) year; 
         mint[j][i]= (double)month; 
         strcpy(line,stra);
       } /* ENd Waves */
       
       cutv(stra, strb,line,' '); 
       if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
       }
       else  if(iout=sscanf(strb,"%s.",dummy) != 0){
         month=99;
         year=9999;
       }else{
         printf("Error reading data around '%s' at line number %ld %s for individual %d, '%s'\nShould be a date of death (mm/yyyy or .).  Exiting.\n",strb, linei,i,line);
         exit(1);
       }
       andc[i]=(double) year; 
       moisdc[i]=(double) month; 
       strcpy(line,stra);
       
       cutv(stra, strb,line,' '); 
       if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
       }
       else  if(iout=sscanf(strb,"%s.") != 0){
         month=99;
         year=9999;
       }else{
         printf("Error reading data around '%s' at line number %ld %s for individual %d, '%s'\nShould be a date of birth (mm/yyyy or .).  Exiting.\n",strb, linei,i,line,j);
         exit(1);
       }
       annais[i]=(double)(year);
       moisnais[i]=(double)(month); 
       strcpy(line,stra);
       
       cutv(stra, strb,line,' '); 
       errno=0;
       lval=strtol(strb,&endptr,10); 
       if( strb[0]=='\0' || (*endptr != '\0')){
         printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a weight.  Exiting.\n",lval, i,line,linei);
         exit(1);
       }
       weight[i]=(double)(lval); 
       strcpy(line,stra);
       
       for (j=ncovcol;j>=1;j--){
         cutv(stra, strb,line,' '); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d, '%s'\nShould be a covar (meaning 0 for the reference or 1).  Exiting.\n",lval, linei,i, line);
           exit(1);
         }
         if(lval <-1 || lval >1){
           printf("Error reading data around '%d' at line number %ld %s for individual %d, '%s'\nShould be a value of the %d covar (meaning 0 for the reference or 1. IMaCh does not build design variables, do it your self).  Exiting.\n",lval,linei, i,line,j);
           exit(1);
         }
         covar[j][i]=(double)(lval);
         strcpy(line,stra);
       } 
       lstra=strlen(stra);
       
       if(lstra > 9){ /* More than 2**32 or max of what printf can write with %ld */
         stratrunc = &(stra[lstra-9]);
         num[i]=atol(stratrunc);
       }
       else
         num[i]=atol(stra);
       /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){
         printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/
       
       i=i+1;
     } /* End loop reading  data */
     fclose(fic);
     /* printf("ii=%d", ij);
        scanf("%d",i);*/
     imx=i-1; /* Number of individuals */
   
     /* for (i=1; i<=imx; i++){
       if ((s[1][i]==3) && (s[2][i]==2)) s[2][i]=3;
       if ((s[2][i]==3) && (s[3][i]==2)) s[3][i]=3;
       if ((s[3][i]==3) && (s[4][i]==2)) s[4][i]=3;
       }*/
      /*  for (i=1; i<=imx; i++){
        if (s[4][i]==9)  s[4][i]=-1; 
        printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));}*/
     
     /* for (i=1; i<=imx; i++) */
    
      /*if ((s[3][i]==3) ||  (s[4][i]==3)) weight[i]=0.08;
        else weight[i]=1;*/
   
     /* Calculation of the number of parameters from char model */
     Tvar=ivector(1,15); /* stores the number n of the covariates in Vm+Vn at 1 and m at 2 */
     Tprod=ivector(1,15); 
     Tvaraff=ivector(1,15); 
     Tvard=imatrix(1,15,1,2);
     Tage=ivector(1,15);      
      
     if (strlen(model) >1){ /* If there is at least 1 covariate */
       j=0, j1=0, k1=1, k2=1;
       j=nbocc(model,'+'); /* j=Number of '+' */
       j1=nbocc(model,'*'); /* j1=Number of '*' */
       cptcovn=j+1; 
       cptcovprod=j1; /*Number of products */
       
       strcpy(modelsav,model); 
       if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){
         printf("Error. Non available option model=%s ",model);
         fprintf(ficlog,"Error. Non available option model=%s ",model);
         goto end;
       }
       
       /* This loop fills the array Tvar from the string 'model'.*/
   
       for(i=(j+1); i>=1;i--){
         cutv(stra,strb,modelsav,'+'); /* keeps in strb after the last + */ 
         if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav); /* and analyzes it */
         /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/
         /*scanf("%d",i);*/
         if (strchr(strb,'*')) {  /* Model includes a product */
           cutv(strd,strc,strb,'*'); /* strd*strc  Vm*Vn (if not *age)*/
           if (strcmp(strc,"age")==0) { /* Vn*age */
             cptcovprod--;
             cutv(strb,stre,strd,'V');
             Tvar[i]=atoi(stre); /* computes n in Vn and stores in Tvar*/
             cptcovage++;
               Tage[cptcovage]=i;
               /*printf("stre=%s ", stre);*/
           }
           else if (strcmp(strd,"age")==0) { /* or age*Vn */
             cptcovprod--;
             cutv(strb,stre,strc,'V');
             Tvar[i]=atoi(stre);
             cptcovage++;
             Tage[cptcovage]=i;
           }
           else {  /* Age is not in the model */
             cutv(strb,stre,strc,'V'); /* strc= Vn, stre is n*/
             Tvar[i]=ncovcol+k1;
             cutv(strb,strc,strd,'V'); /* strd was Vm, strc is m */
             Tprod[k1]=i;
             Tvard[k1][1]=atoi(strc); /* m*/
             Tvard[k1][2]=atoi(stre); /* n */
             Tvar[cptcovn+k2]=Tvard[k1][1];
             Tvar[cptcovn+k2+1]=Tvard[k1][2]; 
             for (k=1; k<=lastobs;k++) 
               covar[ncovcol+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];
             k1++;
             k2=k2+2;
           }
         }
         else { /* no more sum */
           /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/
          /*  scanf("%d",i);*/
         cutv(strd,strc,strb,'V');
         Tvar[i]=atoi(strc);
         }
         strcpy(modelsav,stra);  
         /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);
           scanf("%d",i);*/
       } /* end of loop + */
     } /* end model */
     
     /*The number n of Vn is stored in Tvar. cptcovage =number of age covariate. Tage gives the position of age. cptcovprod= number of products.
       If model=V1+V1*age then Tvar[1]=1 Tvar[2]=1 cptcovage=1 Tage[1]=2 cptcovprod=0*/
   
     /* printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);
     printf("cptcovprod=%d ", cptcovprod);
     fprintf(ficlog,"cptcovprod=%d ", cptcovprod);
   
     scanf("%d ",i);*/
   
       /*  if(mle==1){*/
     if (weightopt != 1) { /* Maximisation without weights*/
       for(i=1;i<=n;i++) weight[i]=1.0;
     }
       /*-calculation of age at interview from date of interview and age at death -*/
     agev=matrix(1,maxwav,1,imx);
   
     for (i=1; i<=imx; i++) {
       for(m=2; (m<= maxwav); m++) {
         if (((int)mint[m][i]== 99) && (s[m][i] <= nlstate)){
           anint[m][i]=9999;
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]==9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           fprintf(ficlog,"Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]!=9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Month of death of individual %ld on line %d was unknown %2d, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,(int)moisdc[i]); 
           fprintf(ficlog,"Error! Month of death of individual %ld on line %d was unknown %f, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,moisdc[i]); 
           s[m][i]=-1; /* We prefer to skip it (and to skip it in version 0.8a1 too */
         }
       }
     }
   
     for (i=1; i<=imx; i++)  {
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);
       for(m=firstpass; (m<= lastpass); m++){
         if(s[m][i] >0 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5){
           if (s[m][i] >= nlstate+1) {
             if(agedc[i]>0)
               if((int)moisdc[i]!=99 && (int)andc[i]!=9999)
                 agev[m][i]=agedc[i];
             /*if(moisdc[i]==99 && andc[i]==9999) s[m][i]=-1;*/
               else {
                 if ((int)andc[i]!=9999){
                   nbwarn++;
                   printf("Warning negative age at death: %ld line:%d\n",num[i],i);
                   fprintf(ficlog,"Warning negative age at death: %ld line:%d\n",num[i],i);
                   agev[m][i]=-1;
                 }
               }
           }
           else if(s[m][i] !=9){ /* Standard case, age in fractional
                                    years but with the precision of a month */
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);
             if((int)mint[m][i]==99 || (int)anint[m][i]==9999)
               agev[m][i]=1;
             else if(agev[m][i] <agemin){ 
               agemin=agev[m][i];
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/
             }
             else if(agev[m][i] >agemax){
               agemax=agev[m][i];
               /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/
             }
             /*agev[m][i]=anint[m][i]-annais[i];*/
             /*     agev[m][i] = age[i]+2*m;*/
           }
           else { /* =9 */
             agev[m][i]=1;
             s[m][i]=-1;
           }
         }
         else /*= 0 Unknown */
           agev[m][i]=1;
       }
       
     }
     for (i=1; i<=imx; i++)  {
       for(m=firstpass; (m<=lastpass); m++){
         if (s[m][i] > (nlstate+ndeath)) {
           nberr++;
           printf("Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           fprintf(ficlog,"Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           goto end;
         }
       }
     }
   
     /*for (i=1; i<=imx; i++){
     for (m=firstpass; (m<lastpass); m++){
        printf("%ld %d %.lf %d %d\n", num[i],(covar[1][i]),agev[m][i],s[m][i],s[m+1][i]);
   }
   
   }*/
   
   
     printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);
     fprintf(ficlog,"Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax); 
   
     agegomp=(int)agemin;
     free_vector(severity,1,maxwav);
     free_imatrix(outcome,1,maxwav+1,1,n);
     free_vector(moisnais,1,n);
     free_vector(annais,1,n);
     /* free_matrix(mint,1,maxwav,1,n);
        free_matrix(anint,1,maxwav,1,n);*/
     free_vector(moisdc,1,n);
     free_vector(andc,1,n);
   
      
     wav=ivector(1,imx);
     dh=imatrix(1,lastpass-firstpass+1,1,imx);
     bh=imatrix(1,lastpass-firstpass+1,1,imx);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);
      
     /* Concatenates waves */
     concatwav(wav, dh, bh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);
   
     /* Routine tricode is to calculate cptcoveff (real number of unique covariates) and to associate covariable number and modality */
   
     Tcode=ivector(1,100);
     nbcode=imatrix(0,NCOVMAX,0,NCOVMAX); 
     ncodemax[1]=1;
     if (cptcovn > 0) tricode(Tvar,nbcode,imx);
         
     codtab=imatrix(1,100,1,10); /* Cross tabulation to get the order of 
                                    the estimations*/
     h=0;
     m=pow(2,cptcoveff);
    
     for(k=1;k<=cptcoveff; k++){
       for(i=1; i <=(m/pow(2,k));i++){
         for(j=1; j <= ncodemax[k]; j++){
           for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){
             h++;
             if (h>m) h=1;codtab[h][k]=j;codtab[h][Tvar[k]]=j;
             /*  printf("h=%d k=%d j=%d codtab[h][k]=%d tvar[k]=%d \n",h, k,j,codtab[h][k],Tvar[k]);*/
           } 
         }
       }
     } 
     /* printf("codtab[1][2]=%d codtab[2][2]=%d",codtab[1][2],codtab[2][2]); 
        codtab[1][2]=1;codtab[2][2]=2; */
     /* for(i=1; i <=m ;i++){ 
        for(k=1; k <=cptcovn; k++){
        printf("i=%d k=%d %d %d ",i,k,codtab[i][k], cptcoveff);
        }
        printf("\n");
        }
        scanf("%d",i);*/
       
     /*------------ gnuplot -------------*/
     strcpy(optionfilegnuplot,optionfilefiname);
     if(mle==-3)
       strcat(optionfilegnuplot,"-mort");
     strcat(optionfilegnuplot,".gp");
   
     if((ficgp=fopen(optionfilegnuplot,"w"))==NULL) {
       printf("Problem with file %s",optionfilegnuplot);
     }
     else{
       fprintf(ficgp,"\n# %s\n", version); 
       fprintf(ficgp,"# %s\n", optionfilegnuplot); 
       fprintf(ficgp,"set missing 'NaNq'\n");
     }
     /*  fclose(ficgp);*/
     /*--------- index.htm --------*/
   
     strcpy(optionfilehtm,optionfilefiname); /* Main html file */
     if(mle==-3)
       strcat(optionfilehtm,"-mort");
     strcat(optionfilehtm,".htm");
     if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtm), exit(0);
     }
   
     strcpy(optionfilehtmcov,optionfilefiname); /* Only for matrix of covariance */
     strcat(optionfilehtmcov,"-cov.htm");
     if((fichtmcov=fopen(optionfilehtmcov,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtmcov), exit(0);
     }
     else{
     fprintf(fichtmcov,"<body>\n<title>IMaCh Cov %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model);
     }
   
     fprintf(fichtm,"<body>\n<title>IMaCh %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n\
   \n\
   <hr  size=\"2\" color=\"#EC5E5E\">\
    <ul><li><h4>Parameter files</h4>\n\
    - Parameter file: <a href=\"%s.%s\">%s.%s</a><br>\n\
    - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>\n\
    - Log file of the run: <a href=\"%s\">%s</a><br>\n\
    - Gnuplot file name: <a href=\"%s\">%s</a><br>\n\
    - Date and time at start: %s</ul>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model,\
             optionfilefiname,optionfilext,optionfilefiname,optionfilext,\
             fileres,fileres,\
             filelog,filelog,optionfilegnuplot,optionfilegnuplot,strstart);
     fflush(fichtm);
   
     strcpy(pathr,path);
     strcat(pathr,optionfilefiname);
     chdir(optionfilefiname); /* Move to directory named optionfile */
     
     /* Calculates basic frequencies. Computes observed prevalence at single age
        and prints on file fileres'p'. */
     freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart);
   
     fprintf(fichtm,"\n");
     fprintf(fichtm,"<br>Total number of observations=%d <br>\n\
   Youngest age at first (selected) pass %.2f, oldest age %.2f<br>\n\
   Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>\n",\
             imx,agemin,agemax,jmin,jmax,jmean);
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */
       
      
     /* For Powell, parameters are in a vector p[] starting at p[1]
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */
   
     globpr=0; /* To get the number ipmx of contributions and the sum of weights*/
   
     if (mle==-3){
       ximort=matrix(1,NDIM,1,NDIM);
       cens=ivector(1,n);
       ageexmed=vector(1,n);
       agecens=vector(1,n);
       dcwave=ivector(1,n);
    
       for (i=1; i<=imx; i++){
         dcwave[i]=-1;
         for (m=firstpass; m<=lastpass; m++)
           if (s[m][i]>nlstate) {
             dcwave[i]=m;
             /*    printf("i=%d j=%d s=%d dcwave=%d\n",i,j, s[j][i],dcwave[i]);*/
             break;
           }
       }
   
       for (i=1; i<=imx; i++) {
         if (wav[i]>0){
           ageexmed[i]=agev[mw[1][i]][i];
           j=wav[i];
           agecens[i]=1.; 
   
           if (ageexmed[i]> 1 && wav[i] > 0){
             agecens[i]=agev[mw[j][i]][i];
             cens[i]= 1;
           }else if (ageexmed[i]< 1) 
             cens[i]= -1;
           if (agedc[i]< AGESUP && agedc[i]>1 && dcwave[i]>firstpass && dcwave[i]<=lastpass)
             cens[i]=0 ;
         }
         else cens[i]=-1;
       }
       
       for (i=1;i<=NDIM;i++) {
         for (j=1;j<=NDIM;j++)
           ximort[i][j]=(i == j ? 1.0 : 0.0);
       }
       
       p[1]=0.0268; p[NDIM]=0.083;
       /*printf("%lf %lf", p[1], p[2]);*/
       
       
       printf("Powell\n");  fprintf(ficlog,"Powell\n");
       strcpy(filerespow,"pow-mort"); 
       strcat(filerespow,fileres);
       if((ficrespow=fopen(filerespow,"w"))==NULL) {
         printf("Problem with resultfile: %s\n", filerespow);
         fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
       }
       fprintf(ficrespow,"# Powell\n# iter -2*LL");
       /*  for (i=1;i<=nlstate;i++)
           for(j=1;j<=nlstate+ndeath;j++)
           if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
       */
       fprintf(ficrespow,"\n");
       
       powell(p,ximort,NDIM,ftol,&iter,&fret,gompertz);
       fclose(ficrespow);
       
       hesscov(matcov, p, NDIM, delti, 1e-4, gompertz); 
   
       for(i=1; i <=NDIM; i++)
         for(j=i+1;j<=NDIM;j++)
           matcov[i][j]=matcov[j][i];
       
       printf("\nCovariance matrix\n ");
       for(i=1; i <=NDIM; i++) {
         for(j=1;j<=NDIM;j++){ 
           printf("%f ",matcov[i][j]);
         }
         printf("\n ");
       }
       
       printf("iter=%d MLE=%f Eq=%lf*exp(%lf*(age-%d))\n",iter,-gompertz(p),p[1],p[2],agegomp);
       for (i=1;i<=NDIM;i++) 
         printf("%f [%f ; %f]\n",p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
   
       lsurv=vector(1,AGESUP);
       lpop=vector(1,AGESUP);
       tpop=vector(1,AGESUP);
       lsurv[agegomp]=100000;
       
       for (k=agegomp;k<=AGESUP;k++) {
         agemortsup=k;
         if (p[1]*exp(p[2]*(k-agegomp))>1) break;
       }
       
       for (k=agegomp;k<agemortsup;k++)
         lsurv[k+1]=lsurv[k]-lsurv[k]*(p[1]*exp(p[2]*(k-agegomp)));
       
       for (k=agegomp;k<agemortsup;k++){
         lpop[k]=(lsurv[k]+lsurv[k+1])/2.;
         sumlpop=sumlpop+lpop[k];
       }
       
       tpop[agegomp]=sumlpop;
       for (k=agegomp;k<(agemortsup-3);k++){
         /*  tpop[k+1]=2;*/
         tpop[k+1]=tpop[k]-lpop[k];
       }
       
       
       printf("\nAge   lx     qx    dx    Lx     Tx     e(x)\n");
       for (k=agegomp;k<(agemortsup-2);k++) 
         printf("%d %.0lf %lf %.0lf %.0lf %.0lf %lf\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
       
       
       replace_back_to_slash(pathc,pathcd); /* Even gnuplot wants a / */
       printinggnuplotmort(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtmlmort(fileres,title,datafile, firstpass, lastpass, \
                        stepm, weightopt,\
                        model,imx,p,matcov,agemortsup);
       
       free_vector(lsurv,1,AGESUP);
       free_vector(lpop,1,AGESUP);
       free_vector(tpop,1,AGESUP);
     } /* Endof if mle==-3 */
     
     else{ /* For mle >=1 */
     
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("First Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       globpr=1; /* to print the contributions */
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("Second Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       if(mle>=1){ /* Could be 1 or 2 */
         mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);
       }
       
       /*--------- results files --------------*/
       fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle= 0 weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate, ndeath, maxwav, weightopt,model);
       
       
       fprintf(ficres,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       fprintf(ficlog,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(k=1; k <=(nlstate+ndeath); k++){
           if (k != i) {
             printf("%d%d ",i,k);
             fprintf(ficlog,"%d%d ",i,k);
             fprintf(ficres,"%1d%1d ",i,k);
             for(j=1; j <=ncovmodel; j++){
               printf("%f ",p[jk]);
               fprintf(ficlog,"%f ",p[jk]);
               fprintf(ficres,"%f ",p[jk]);
               jk++; 
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       if(mle!=0){
         /* Computing hessian and covariance matrix */
         ftolhess=ftol; /* Usually correct */
         hesscov(matcov, p, npar, delti, ftolhess, func);
       }
       fprintf(ficres,"# Scales (for hessian or gradient estimation)\n");
       printf("# Scales (for hessian or gradient estimation)\n");
       fprintf(ficlog,"# Scales (for hessian or gradient estimation)\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if (j!=i) {
             fprintf(ficres,"%1d%1d",i,j);
             printf("%1d%1d",i,j);
             fprintf(ficlog,"%1d%1d",i,j);
             for(k=1; k<=ncovmodel;k++){
               printf(" %.5e",delti[jk]);
               fprintf(ficlog," %.5e",delti[jk]);
               fprintf(ficres," %.5e",delti[jk]);
               jk++;
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       
       fprintf(ficres,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       if(mle>=1)
         printf("# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       fprintf(ficlog,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       /* # 121 Var(a12)\n\ */
       /* # 122 Cov(b12,a12) Var(b12)\n\ */
       /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
       /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
       /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
       /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
       /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
       /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
       
       
       /* Just to have a covariance matrix which will be more understandable
          even is we still don't want to manage dictionary of variables
       */
       for(itimes=1;itimes<=2;itimes++){
         jj=0;
         for(i=1; i <=nlstate; i++){
           for(j=1; j <=nlstate+ndeath; j++){
             if(j==i) continue;
             for(k=1; k<=ncovmodel;k++){
               jj++;
               ca[0]= k+'a'-1;ca[1]='\0';
               if(itimes==1){
                 if(mle>=1)
                   printf("#%1d%1d%d",i,j,k);
                 fprintf(ficlog,"#%1d%1d%d",i,j,k);
                 fprintf(ficres,"#%1d%1d%d",i,j,k);
               }else{
                 if(mle>=1)
                   printf("%1d%1d%d",i,j,k);
                 fprintf(ficlog,"%1d%1d%d",i,j,k);
                 fprintf(ficres,"%1d%1d%d",i,j,k);
               }
               ll=0;
               for(li=1;li <=nlstate; li++){
                 for(lj=1;lj <=nlstate+ndeath; lj++){
                   if(lj==li) continue;
                   for(lk=1;lk<=ncovmodel;lk++){
                     ll++;
                     if(ll<=jj){
                       cb[0]= lk +'a'-1;cb[1]='\0';
                       if(ll<jj){
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficlog," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficres," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }else{
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficlog," Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficres," Var(%s%1d%1d)",ca,i,j);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }
                     }
                   } /* end lk */
                 } /* end lj */
               } /* end li */
               if(mle>=1)
                 printf("\n");
               fprintf(ficlog,"\n");
               fprintf(ficres,"\n");
               numlinepar++;
             } /* end k*/
           } /*end j */
         } /* end i */
       } /* end itimes */
       
       fflush(ficlog);
       fflush(ficres);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       estepm=0;
       fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf estepm=%d\n",&ageminpar,&agemaxpar, &bage, &fage, &estepm);
       if (estepm==0 || estepm < stepm) estepm=stepm;
       if (fage <= 2) {
         bage = ageminpar;
         fage = agemaxpar;
       }
       
       fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");
       fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"begin-prev-date=%lf/%lf/%lf end-prev-date=%lf/%lf/%lf mov_average=%d\n",&jprev1, &mprev1,&anprev1,&jprev2, &mprev2,&anprev2,&mobilav);
       fprintf(ficparo,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficres,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       printf("begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficlog,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       
       dateprev1=anprev1+(mprev1-1)/12.+(jprev1-1)/365.;
       dateprev2=anprev2+(mprev2-1)/12.+(jprev2-1)/365.;
       
       fscanf(ficpar,"pop_based=%d\n",&popbased);
       fprintf(ficparo,"pop_based=%d\n",popbased);   
       fprintf(ficres,"pop_based=%d\n",popbased);   
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"prevforecast=%d starting-proj-date=%lf/%lf/%lf final-proj-date=%lf/%lf/%lf mobil_average=%d\n",&prevfcast,&jproj1,&mproj1,&anproj1,&jproj2,&mproj2,&anproj2,&mobilavproj);
       fprintf(ficparo,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       printf("prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficlog,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficres,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       /* day and month of proj2 are not used but only year anproj2.*/
       
       
       
       /*  freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);*/
       /*,dateprev1,dateprev2,jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
       
       replace_back_to_slash(pathc,pathcd); /* Even gnuplot wants a / */
       printinggnuplot(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtml(fileres,title,datafile, firstpass, lastpass, stepm, weightopt,\
                    model,imx,jmin,jmax,jmean,rfileres,popforecast,estepm,\
                    jprev1,mprev1,anprev1,jprev2,mprev2,anprev2);
         
      /*------------ free_vector  -------------*/
      /*  chdir(path); */
    
       free_ivector(wav,1,imx);
       free_imatrix(dh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(bh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
       free_lvector(num,1,n);
       free_vector(agedc,1,n);
       /*free_matrix(covar,0,NCOVMAX,1,n);*/
       /*free_matrix(covar,1,NCOVMAX,1,n);*/
       fclose(ficparo);
       fclose(ficres);
   
   
       /*--------------- Prevalence limit  (period or stable prevalence) --------------*/
     
       strcpy(filerespl,"pl");
       strcat(filerespl,fileres);
       if((ficrespl=fopen(filerespl,"w"))==NULL) {
         printf("Problem with period (stable) prevalence resultfile: %s\n", filerespl);goto end;
         fprintf(ficlog,"Problem with period (stable) prevalence resultfile: %s\n", filerespl);goto end;
       }
       printf("Computing period (stable) prevalence: result on file '%s' \n", filerespl);
       fprintf(ficlog,"Computing period (stable) prevalence: result on file '%s' \n", filerespl);
       pstamp(ficrespl);
       fprintf(ficrespl,"# Period (stable) prevalence \n");
       fprintf(ficrespl,"#Age ");
       for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);
       fprintf(ficrespl,"\n");
     
       prlim=matrix(1,nlstate,1,nlstate);
   
       agebase=ageminpar;
       agelim=agemaxpar;
       ftolpl=1.e-10;
       i1=cptcoveff;
       if (cptcovn < 1){i1=1;}
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/
           fprintf(ficrespl,"\n#******");
           printf("\n#******");
           fprintf(ficlog,"\n#******");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             printf(" V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficlog," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficrespl,"******\n");
           printf("******\n");
           fprintf(ficlog,"******\n");
           
           for (age=agebase; age<=agelim; age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             fprintf(ficrespl,"%.0f ",age );
             for(j=1;j<=cptcoveff;j++)
               fprintf(ficrespl,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             for(i=1; i<=nlstate;i++)
               fprintf(ficrespl," %.5f", prlim[i][i]);
             fprintf(ficrespl,"\n");
           }
         }
       }
       fclose(ficrespl);
   
       /*------------- h Pij x at various ages ------------*/
     
       strcpy(filerespij,"pij");  strcat(filerespij,fileres);
       if((ficrespij=fopen(filerespij,"w"))==NULL) {
         printf("Problem with Pij resultfile: %s\n", filerespij);goto end;
         fprintf(ficlog,"Problem with Pij resultfile: %s\n", filerespij);goto end;
       }
       printf("Computing pij: result on file '%s' \n", filerespij);
       fprintf(ficlog,"Computing pij: result on file '%s' \n", filerespij);
     
       stepsize=(int) (stepm+YEARM-1)/YEARM;
       /*if (stepm<=24) stepsize=2;*/
   
       agelim=AGESUP;
       hstepm=stepsize*YEARM; /* Every year of age */
       hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */ 
   
       /* hstepm=1;   aff par mois*/
       pstamp(ficrespij);
       fprintf(ficrespij,"#****** h Pij x Probability to be in state j at age x+h being in i at x ");
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficrespij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrespij,"******\n");
           
           for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
             nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
   
             /*      nhstepm=nhstepm*YEARM; aff par mois*/
   
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             fprintf(ficrespij,"# Cov Agex agex+h hpijx with i,j=");
             for(i=1; i<=nlstate;i++)
               for(j=1; j<=nlstate+ndeath;j++)
                 fprintf(ficrespij," %1d-%1d",i,j);
             fprintf(ficrespij,"\n");
             for (h=0; h<=nhstepm; h++){
               fprintf(ficrespij,"%d %3.f %3.f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );
               for(i=1; i<=nlstate;i++)
                 for(j=1; j<=nlstate+ndeath;j++)
                   fprintf(ficrespij," %.5f", p3mat[i][j][h]);
               fprintf(ficrespij,"\n");
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             fprintf(ficrespij,"\n");
           }
         }
       }
   
       varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax,strstart);
   
       fclose(ficrespij);
   
       probs= ma3x(1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
       for(i=1;i<=AGESUP;i++)
         for(j=1;j<=NCOVMAX;j++)
           for(k=1;k<=NCOVMAX;k++)
             probs[i][j][k]=0.;
   
       /*---------- Forecasting ------------------*/
       /*if((stepm == 1) && (strcmp(model,".")==0)){*/
       if(prevfcast==1){
         /*    if(stepm ==1){*/
         prevforecast(fileres, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff);
         /* (popforecast==1) populforecast(fileres, anpyram,mpyram,jpyram, agemin,agemax, dateprev1, dateprev2,mobilav, agedeb, fage, popforecast, popfile, anpyram1,p, i1);*/
         /*      }  */
         /*      else{ */
         /*        erreur=108; */
         /*        printf("Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*        fprintf(ficlog,"Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*      } */
       }
     
   
       /*---------- Health expectancies and variances ------------*/
   
       strcpy(filerest,"t");
       strcat(filerest,fileres);
       if((ficrest=fopen(filerest,"w"))==NULL) {
         printf("Problem with total LE resultfile: %s\n", filerest);goto end;
         fprintf(ficlog,"Problem with total LE resultfile: %s\n", filerest);goto end;
       }
       printf("Computing Total Life expectancies with their standard errors: file '%s' \n", filerest); 
       fprintf(ficlog,"Computing Total Life expectancies with their standard errors: file '%s' \n", filerest); 
   
   
       strcpy(filerese,"e");
       strcat(filerese,fileres);
       if((ficreseij=fopen(filerese,"w"))==NULL) {
         printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
         fprintf(ficlog,"Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
       }
       printf("Computing Health Expectancies: result on file '%s' \n", filerese);
       fprintf(ficlog,"Computing Health Expectancies: result on file '%s' \n", filerese);
   
       strcpy(fileresstde,"stde");
       strcat(fileresstde,fileres);
       if((ficresstdeij=fopen(fileresstde,"w"))==NULL) {
         printf("Problem with Health Exp. and std errors resultfile: %s\n", fileresstde); exit(0);
         fprintf(ficlog,"Problem with Health Exp. and std errors resultfile: %s\n", fileresstde); exit(0);
       }
       printf("Computing Health Expectancies and standard errors: result on file '%s' \n", fileresstde);
       fprintf(ficlog,"Computing Health Expectancies and standard errors: result on file '%s' \n", fileresstde);
   
       strcpy(filerescve,"cve");
       strcat(filerescve,fileres);
       if((ficrescveij=fopen(filerescve,"w"))==NULL) {
         printf("Problem with Covar. Health Exp. resultfile: %s\n", filerescve); exit(0);
         fprintf(ficlog,"Problem with Covar. Health Exp. resultfile: %s\n", filerescve); exit(0);
       }
       printf("Computing Covar. of Health Expectancies: result on file '%s' \n", filerescve);
       fprintf(ficlog,"Computing Covar. of Health Expectancies: result on file '%s' \n", filerescve);
   
       strcpy(fileresv,"v");
       strcat(fileresv,fileres);
       if((ficresvij=fopen(fileresv,"w"))==NULL) {
         printf("Problem with variance resultfile: %s\n", fileresv);exit(0);
         fprintf(ficlog,"Problem with variance resultfile: %s\n", fileresv);exit(0);
       }
       printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
       fprintf(ficlog,"Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
   
       /* Computes prevalence between agemin (i.e minimal age computed) and no more ageminpar */
       prevalence(probs, agemin, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
       /*  printf("ageminpar=%f, agemax=%f, s[lastpass][imx]=%d, agev[lastpass][imx]=%f, nlstate=%d, imx=%d,  mint[lastpass][imx]=%f, anint[lastpass][imx]=%f,dateprev1=%f, dateprev2=%f, firstpass=%d, lastpass=%d\n",\
           ageminpar, agemax, s[lastpass][imx], agev[lastpass][imx], nlstate, imx, mint[lastpass][imx],anint[lastpass][imx], dateprev1, dateprev2, firstpass, lastpass);
       */
   
       if (mobilav!=0) {
         mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
         if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
           fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
           printf(" Error in movingaverage mobilav=%d\n",mobilav);
         }
       }
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1; 
           fprintf(ficrest,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrest,"******\n");
   
           fprintf(ficreseij,"\n#****** ");
           fprintf(ficresstdeij,"\n#****** ");
           fprintf(ficrescveij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficreseij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficresstdeij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficrescveij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficreseij,"******\n");
           fprintf(ficresstdeij,"******\n");
           fprintf(ficrescveij,"******\n");
   
           fprintf(ficresvij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvij,"******\n");
   
           eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, strstart);  
           cvevsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, delti, matcov, strstart);  
    
           vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,0, mobilav, strstart);
           if(popbased==1){
             varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,popbased,mobilav, strstart);
           }
   
           pstamp(ficrest);
           fprintf(ficrest,"# Total life expectancy with std error and decomposition into time to be expected in each health state\n# Age ( e.. (std) ");
           for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);
           fprintf(ficrest,"\n");
   
           epj=vector(1,nlstate+1);
           for(age=bage; age <=fage ;age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             if (popbased==1) {
               if(mobilav ==0){
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=probs[(int)age][i][k];
               }else{ /* mobilav */ 
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=mobaverage[(int)age][i][k];
               }
             }
           
             fprintf(ficrest," %4.0f",age);
             for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){
               for(i=1, epj[j]=0.;i <=nlstate;i++) {
                 epj[j] += prlim[i][i]*eij[i][j][(int)age];
                 /*  printf("%lf %lf ", prlim[i][i] ,eij[i][j][(int)age]);*/
               }
               epj[nlstate+1] +=epj[j];
             }
   
             for(i=1, vepp=0.;i <=nlstate;i++)
               for(j=1;j <=nlstate;j++)
                 vepp += vareij[i][j][(int)age];
             fprintf(ficrest," %7.3f (%7.3f)", epj[nlstate+1],sqrt(vepp));
             for(j=1;j <=nlstate;j++){
               fprintf(ficrest," %7.3f (%7.3f)", epj[j],sqrt(vareij[j][j][(int)age]));
             }
             fprintf(ficrest,"\n");
           }
           free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_vector(epj,1,nlstate+1);
         }
       }
       free_vector(weight,1,n);
       free_imatrix(Tvard,1,15,1,2);
       free_imatrix(s,1,maxwav+1,1,n);
       free_matrix(anint,1,maxwav,1,n); 
       free_matrix(mint,1,maxwav,1,n);
       free_ivector(cod,1,n);
       free_ivector(tab,1,NCOVMAX);
       fclose(ficreseij);
       fclose(ficresstdeij);
       fclose(ficrescveij);
       fclose(ficresvij);
       fclose(ficrest);
       fclose(ficpar);
     
       /*------- Variance of period (stable) prevalence------*/   
   
       strcpy(fileresvpl,"vpl");
       strcat(fileresvpl,fileres);
       if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {
         printf("Problem with variance of period (stable) prevalence  resultfile: %s\n", fileresvpl);
         exit(0);
       }
       printf("Computing Variance-covariance of period (stable) prevalence: file '%s' \n", fileresvpl);
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficresvpl,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvpl,"******\n");
         
           varpl=matrix(1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k,strstart);
           free_matrix(varpl,1,nlstate,(int) bage, (int)fage);
         }
       }
   
       fclose(ficresvpl);
   
       /*---------- End : free ----------------*/
       if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       free_ma3x(probs,1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     }  /* mle==-3 arrives here for freeing */
     free_matrix(prlim,1,nlstate,1,nlstate);
       free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(covar,0,NCOVMAX,1,n);
       free_matrix(matcov,1,npar,1,npar);
       /*free_vector(delti,1,npar);*/
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       free_matrix(agev,1,maxwav,1,imx);
       free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);
   
       free_ivector(ncodemax,1,8);
       free_ivector(Tvar,1,15);
       free_ivector(Tprod,1,15);
       free_ivector(Tvaraff,1,15);
       free_ivector(Tage,1,15);
       free_ivector(Tcode,1,100);
   
       free_imatrix(nbcode,0,NCOVMAX,0,NCOVMAX);
       free_imatrix(codtab,1,100,1,10);
     fflush(fichtm);
     fflush(ficgp);
     
   
     if((nberr >0) || (nbwarn>0)){
       printf("End of Imach with %d errors and/or %d warnings\n",nberr,nbwarn);
       fprintf(ficlog,"End of Imach with %d errors and/or warnings %d\n",nberr,nbwarn);
     }else{
       printf("End of Imach\n");
       fprintf(ficlog,"End of Imach\n");
     }
     printf("See log file on %s\n",filelog);
     /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */
     (void) gettimeofday(&end_time,&tzp);
     tm = *localtime(&end_time.tv_sec);
     tmg = *gmtime(&end_time.tv_sec);
     strcpy(strtend,asctime(&tm));
     printf("Local time at start %s\nLocal time at end   %s",strstart, strtend); 
     fprintf(ficlog,"Local time at start %s\nLocal time at end   %s\n",strstart, strtend); 
     printf("Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
   
     printf("Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     fprintf(ficlog,"Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
     fprintf(ficlog,"Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     /*  printf("Total time was %d uSec.\n", total_usecs);*/
   /*   if(fileappend(fichtm,optionfilehtm)){ */
     fprintf(fichtm,"<br>Local time at start %s<br>Local time at end   %s<br>",strstart, strtend);
     fclose(fichtm);
     fclose(fichtmcov);
     fclose(ficgp);
     fclose(ficlog);
     /*------ End -----------*/
   
   
      printf("Before Current directory %s!\n",pathcd);
      if(chdir(pathcd) != 0)
       printf("Can't move to directory %s!\n",path);
     if(getcwd(pathcd,MAXLINE) > 0)
       printf("Current directory %s!\n",pathcd);
     /*strcat(plotcmd,CHARSEPARATOR);*/
     sprintf(plotcmd,"gnuplot");
   #ifndef UNIX
     sprintf(plotcmd,"\"%sgnuplot.exe\"",pathimach);
   #endif
     if(!stat(plotcmd,&info)){
       printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
       if(!stat(getenv("GNUPLOTBIN"),&info)){
         printf("Error gnuplot program not found: %s Environment GNUPLOTBIN not set.\n",plotcmd);fflush(stdout);
       }else
         strcpy(pplotcmd,plotcmd);
   #ifdef UNIX
       strcpy(plotcmd,GNUPLOTPROGRAM);
       if(!stat(plotcmd,&info)){
         printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
       }else
         strcpy(pplotcmd,plotcmd);
   #endif
     }else
       strcpy(pplotcmd,plotcmd);
     
     sprintf(plotcmd,"%s %s",pplotcmd, optionfilegnuplot);
     printf("Starting graphs with: %s\n",plotcmd);fflush(stdout);
   
     if((outcmd=system(plotcmd)) != 0){
       printf("\n Problem with gnuplot\n");
     }
     printf(" Wait...");
     while (z[0] != 'q') {
       /* chdir(path); */
       printf("\nType e to edit output files, g to graph again and q for exiting: ");
       scanf("%s",z);
   /*     if (z[0] == 'c') system("./imach"); */
       if (z[0] == 'e') {
         printf("Starting browser with: %s",optionfilehtm);fflush(stdout);
         system(optionfilehtm);
       }
       else if (z[0] == 'g') system(plotcmd);
       else if (z[0] == 'q') exit(0);
     }
     end:
     while (z[0] != 'q') {
       printf("\nType  q for exiting: ");
       scanf("%s",z);
     }
   }
   
   
   

Removed from v.1.11  
changed lines
  Added in v.1.121


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