Diff for /imach/src/imach.c between versions 1.7 and 1.138

version 1.7, 2001/05/02 17:50:24 version 1.138, 2010/04/30 18:19:40
Line 1 Line 1
      /* $Id$
 /*********************** Imach **************************************            $State$
   This program computes Healthy Life Expectancies from cross-longitudinal    $Log$
   data. Cross-longitudinal consist in a first survey ("cross") where    Revision 1.138  2010/04/30 18:19:40  brouard
   individuals from different ages are interviewed on their health status    *** empty log message ***
   or degree of  disability. At least a second wave of interviews  
   ("longitudinal") should  measure each new individual health status.    Revision 1.137  2010/04/29 18:11:38  brouard
   Health expectancies are computed from the transistions observed between    (Module): Checking covariates for more complex models
   waves and are computed for each degree of severity of disability (number    than V1+V2. A lot of change to be done. Unstable.
   of life states). More degrees you consider, more time is necessary to  
   reach the Maximum Likelihood of the parameters involved in the model.    Revision 1.136  2010/04/26 20:30:53  brouard
   The simplest model is the multinomial logistic model where pij is    (Module): merging some libgsl code. Fixing computation
   the probabibility to be observed in state j at the second wave conditional    of likelione (using inter/intrapolation if mle = 0) in order to
   to be observed in state i at the first wave. Therefore the model is:    get same likelihood as if mle=1.
   log(pij/pii)= aij + bij*age+ cij*sex + etc , where 'age' is age and 'sex'    Some cleaning of code and comments added.
   is a covariate. If you want to have a more complex model than "constant and  
   age", you should modify the program where the markup    Revision 1.135  2009/10/29 15:33:14  brouard
     *Covariates have to be included here again* invites you to do it.    (Module): Now imach stops if date of birth, at least year of birth, is not given. Some cleaning of the code.
   More covariates you add, less is the speed of the convergence.  
     Revision 1.134  2009/10/29 13:18:53  brouard
   The advantage that this computer programme claims, comes from that if the    (Module): Now imach stops if date of birth, at least year of birth, is not given. Some cleaning of the code.
   delay between waves is not identical for each individual, or if some  
   individual missed an interview, the information is not rounded or lost, but    Revision 1.133  2009/07/06 10:21:25  brouard
   taken into account using an interpolation or extrapolation.    just nforces
   hPijx is the probability to be  
   observed in state i at age x+h conditional to the observed state i at age    Revision 1.132  2009/07/06 08:22:05  brouard
   x. The delay 'h' can be split into an exact number (nh*stepm) of    Many tings
   unobserved intermediate  states. This elementary transition (by month or  
   quarter trimester, semester or year) is model as a multinomial logistic.    Revision 1.131  2009/06/20 16:22:47  brouard
   The hPx matrix is simply the matrix product of nh*stepm elementary matrices    Some dimensions resccaled
   and the contribution of each individual to the likelihood is simply hPijx.  
     Revision 1.130  2009/05/26 06:44:34  brouard
   Also this programme outputs the covariance matrix of the parameters but also    (Module): Max Covariate is now set to 20 instead of 8. A
   of the life expectancies. It also computes the prevalence limits.    lot of cleaning with variables initialized to 0. Trying to make
      V2+V3*age+V1+V4 strb=V3*age+V1+V4 working better.
   Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).  
            Institut national d'études démographiques, Paris.    Revision 1.129  2007/08/31 13:49:27  lievre
   This software have been partly granted by Euro-REVES, a concerted action    Modification of the way of exiting when the covariate is not binary in order to see on the window the error message before exiting
   from the European Union.  
   It is copyrighted identically to a GNU software product, ie programme and    Revision 1.128  2006/06/30 13:02:05  brouard
   software can be distributed freely for non commercial use. Latest version    (Module): Clarifications on computing e.j
   can be accessed at http://euroreves.ined.fr/imach .  
   **********************************************************************/    Revision 1.127  2006/04/28 18:11:50  brouard
      (Module): Yes the sum of survivors was wrong since
 #include <math.h>    imach-114 because nhstepm was no more computed in the age
 #include <stdio.h>    loop. Now we define nhstepma in the age loop.
 #include <stdlib.h>    (Module): In order to speed up (in case of numerous covariates) we
 #include <unistd.h>    compute health expectancies (without variances) in a first step
     and then all the health expectancies with variances or standard
 #define MAXLINE 256    deviation (needs data from the Hessian matrices) which slows the
 #define FILENAMELENGTH 80    computation.
 /*#define DEBUG*/    In the future we should be able to stop the program is only health
 #define windows    expectancies and graph are needed without standard deviations.
 #define GLOCK_ERROR_NOPATH              -1      /* empty path */  
 #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */    Revision 1.126  2006/04/28 17:23:28  brouard
     (Module): Yes the sum of survivors was wrong since
 #define MAXPARM 30 /* Maximum number of parameters for the optimization */    imach-114 because nhstepm was no more computed in the age
 #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */    loop. Now we define nhstepma in the age loop.
     Version 0.98h
 #define NINTERVMAX 8  
 #define NLSTATEMAX 8 /* Maximum number of live states (for func) */    Revision 1.125  2006/04/04 15:20:31  lievre
 #define NDEATHMAX 8 /* Maximum number of dead states (for func) */    Errors in calculation of health expectancies. Age was not initialized.
 #define NCOVMAX 8 /* Maximum number of covariates */    Forecasting file added.
 #define MAXN 20000  
 #define YEARM 12. /* Number of months per year */    Revision 1.124  2006/03/22 17:13:53  lievre
 #define AGESUP 130    Parameters are printed with %lf instead of %f (more numbers after the comma).
 #define AGEBASE 40    The log-likelihood is printed in the log file
   
     Revision 1.123  2006/03/20 10:52:43  brouard
 int nvar;    * imach.c (Module): <title> changed, corresponds to .htm file
 static int cptcov;    name. <head> headers where missing.
 int cptcovn, cptcovage=0, cptcoveff=0;  
 int npar=NPARMAX;    * imach.c (Module): Weights can have a decimal point as for
 int nlstate=2; /* Number of live states */    English (a comma might work with a correct LC_NUMERIC environment,
 int ndeath=1; /* Number of dead states */    otherwise the weight is truncated).
 int ncovmodel, ncov;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */    Modification of warning when the covariates values are not 0 or
     1.
 int *wav; /* Number of waves for this individuual 0 is possible */    Version 0.98g
 int maxwav; /* Maxim number of waves */  
 int mle, weightopt;    Revision 1.122  2006/03/20 09:45:41  brouard
 int **mw; /* mw[mi][i] is number of the mi wave for this individual */    (Module): Weights can have a decimal point as for
 int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */    English (a comma might work with a correct LC_NUMERIC environment,
 double **oldm, **newm, **savm; /* Working pointers to matrices */    otherwise the weight is truncated).
 double **oldms, **newms, **savms; /* Fixed working pointers to matrices */    Modification of warning when the covariates values are not 0 or
 FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest;    1.
 FILE *ficgp, *fichtm;    Version 0.98g
 FILE *ficreseij;  
   char filerese[FILENAMELENGTH];    Revision 1.121  2006/03/16 17:45:01  lievre
  FILE  *ficresvij;    * imach.c (Module): Comments concerning covariates added
   char fileresv[FILENAMELENGTH];  
  FILE  *ficresvpl;    * imach.c (Module): refinements in the computation of lli if
   char fileresvpl[FILENAMELENGTH];    status=-2 in order to have more reliable computation if stepm is
     not 1 month. Version 0.98f
 #define NR_END 1  
 #define FREE_ARG char*    Revision 1.120  2006/03/16 15:10:38  lievre
 #define FTOL 1.0e-10    (Module): refinements in the computation of lli if
     status=-2 in order to have more reliable computation if stepm is
 #define NRANSI    not 1 month. Version 0.98f
 #define ITMAX 200  
     Revision 1.119  2006/03/15 17:42:26  brouard
 #define TOL 2.0e-4    (Module): Bug if status = -2, the loglikelihood was
     computed as likelihood omitting the logarithm. Version O.98e
 #define CGOLD 0.3819660  
 #define ZEPS 1.0e-10    Revision 1.118  2006/03/14 18:20:07  brouard
 #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d);    (Module): varevsij Comments added explaining the second
     table of variances if popbased=1 .
 #define GOLD 1.618034    (Module): Covariances of eij, ekl added, graphs fixed, new html link.
 #define GLIMIT 100.0    (Module): Function pstamp added
 #define TINY 1.0e-20    (Module): Version 0.98d
   
 static double maxarg1,maxarg2;    Revision 1.117  2006/03/14 17:16:22  brouard
 #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))    (Module): varevsij Comments added explaining the second
 #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))    table of variances if popbased=1 .
      (Module): Covariances of eij, ekl added, graphs fixed, new html link.
 #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))    (Module): Function pstamp added
 #define rint(a) floor(a+0.5)    (Module): Version 0.98d
   
 static double sqrarg;    Revision 1.116  2006/03/06 10:29:27  brouard
 #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)    (Module): Variance-covariance wrong links and
 #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;}    varian-covariance of ej. is needed (Saito).
   
 int imx;    Revision 1.115  2006/02/27 12:17:45  brouard
 int stepm;    (Module): One freematrix added in mlikeli! 0.98c
 /* Stepm, step in month: minimum step interpolation*/  
     Revision 1.114  2006/02/26 12:57:58  brouard
 int m,nb;    (Module): Some improvements in processing parameter
 int *num, firstpass=0, lastpass=4,*cod, *ncodemax, *Tage;    filename with strsep.
 double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;  
 double **pmmij;    Revision 1.113  2006/02/24 14:20:24  brouard
     (Module): Memory leaks checks with valgrind and:
 double *weight;    datafile was not closed, some imatrix were not freed and on matrix
 int **s; /* Status */    allocation too.
 double *agedc, **covar, idx;  
 int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;    Revision 1.112  2006/01/30 09:55:26  brouard
     (Module): Back to gnuplot.exe instead of wgnuplot.exe
 double ftol=FTOL; /* Tolerance for computing Max Likelihood */  
 double ftolhess; /* Tolerance for computing hessian */    Revision 1.111  2006/01/25 20:38:18  brouard
     (Module): Lots of cleaning and bugs added (Gompertz)
 /**************** split *************************/    (Module): Comments can be added in data file. Missing date values
 static  int split( char *path, char *dirc, char *name )    can be a simple dot '.'.
 {  
    char *s;                             /* pointer */    Revision 1.110  2006/01/25 00:51:50  brouard
    int  l1, l2;                         /* length counters */    (Module): Lots of cleaning and bugs added (Gompertz)
   
    l1 = strlen( path );                 /* length of path */    Revision 1.109  2006/01/24 19:37:15  brouard
    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );    (Module): Comments (lines starting with a #) are allowed in data.
    s = strrchr( path, '\\' );           /* find last / */  
    if ( s == NULL ) {                   /* no directory, so use current */    Revision 1.108  2006/01/19 18:05:42  lievre
 #if     defined(__bsd__)                /* get current working directory */    Gnuplot problem appeared...
       extern char       *getwd( );    To be fixed
   
       if ( getwd( dirc ) == NULL ) {    Revision 1.107  2006/01/19 16:20:37  brouard
 #else    Test existence of gnuplot in imach path
       extern char       *getcwd( );  
     Revision 1.106  2006/01/19 13:24:36  brouard
       if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {    Some cleaning and links added in html output
 #endif  
          return( GLOCK_ERROR_GETCWD );    Revision 1.105  2006/01/05 20:23:19  lievre
       }    *** empty log message ***
       strcpy( name, path );             /* we've got it */  
    } else {                             /* strip direcotry from path */    Revision 1.104  2005/09/30 16:11:43  lievre
       s++;                              /* after this, the filename */    (Module): sump fixed, loop imx fixed, and simplifications.
       l2 = strlen( s );                 /* length of filename */    (Module): If the status is missing at the last wave but we know
       if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );    that the person is alive, then we can code his/her status as -2
       strcpy( name, s );                /* save file name */    (instead of missing=-1 in earlier versions) and his/her
       strncpy( dirc, path, l1 - l2 );   /* now the directory */    contributions to the likelihood is 1 - Prob of dying from last
       dirc[l1-l2] = 0;                  /* add zero */    health status (= 1-p13= p11+p12 in the easiest case of somebody in
    }    the healthy state at last known wave). Version is 0.98
    l1 = strlen( dirc );                 /* length of directory */  
    if ( dirc[l1-1] != '\\' ) { dirc[l1] = '\\'; dirc[l1+1] = 0; }    Revision 1.103  2005/09/30 15:54:49  lievre
    return( 0 );                         /* we're done */    (Module): sump fixed, loop imx fixed, and simplifications.
 }  
     Revision 1.102  2004/09/15 17:31:30  brouard
     Add the possibility to read data file including tab characters.
 /******************************************/  
     Revision 1.101  2004/09/15 10:38:38  brouard
 void replace(char *s, char*t)    Fix on curr_time
 {  
   int i;    Revision 1.100  2004/07/12 18:29:06  brouard
   int lg=20;    Add version for Mac OS X. Just define UNIX in Makefile
   i=0;  
   lg=strlen(t);    Revision 1.99  2004/06/05 08:57:40  brouard
   for(i=0; i<= lg; i++) {    *** empty log message ***
     (s[i] = t[i]);  
     if (t[i]== '\\') s[i]='/';    Revision 1.98  2004/05/16 15:05:56  brouard
   }    New version 0.97 . First attempt to estimate force of mortality
 }    directly from the data i.e. without the need of knowing the health
     state at each age, but using a Gompertz model: log u =a + b*age .
 int nbocc(char *s, char occ)    This is the basic analysis of mortality and should be done before any
 {    other analysis, in order to test if the mortality estimated from the
   int i,j=0;    cross-longitudinal survey is different from the mortality estimated
   int lg=20;    from other sources like vital statistic data.
   i=0;  
   lg=strlen(s);    The same imach parameter file can be used but the option for mle should be -3.
   for(i=0; i<= lg; i++) {  
   if  (s[i] == occ ) j++;    Agnès, who wrote this part of the code, tried to keep most of the
   }    former routines in order to include the new code within the former code.
   return j;  
 }    The output is very simple: only an estimate of the intercept and of
     the slope with 95% confident intervals.
 void cutv(char *u,char *v, char*t, char occ)  
 {    Current limitations:
   int i,lg,j,p=0;    A) Even if you enter covariates, i.e. with the
   i=0;    model= V1+V2 equation for example, the programm does only estimate a unique global model without covariates.
   for(j=0; j<=strlen(t)-1; j++) {    B) There is no computation of Life Expectancy nor Life Table.
     if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;  
   }    Revision 1.97  2004/02/20 13:25:42  lievre
     Version 0.96d. Population forecasting command line is (temporarily)
   lg=strlen(t);    suppressed.
   for(j=0; j<p; j++) {  
     (u[j] = t[j]);    Revision 1.96  2003/07/15 15:38:55  brouard
   }    * imach.c (Repository): Errors in subdirf, 2, 3 while printing tmpout is
      u[p]='\0';    rewritten within the same printf. Workaround: many printfs.
   
    for(j=0; j<= lg; j++) {    Revision 1.95  2003/07/08 07:54:34  brouard
     if (j>=(p+1))(v[j-p-1] = t[j]);    * imach.c (Repository):
   }    (Repository): Using imachwizard code to output a more meaningful covariance
 }    matrix (cov(a12,c31) instead of numbers.
   
 /********************** nrerror ********************/    Revision 1.94  2003/06/27 13:00:02  brouard
     Just cleaning
 void nrerror(char error_text[])  
 {    Revision 1.93  2003/06/25 16:33:55  brouard
   fprintf(stderr,"ERREUR ...\n");    (Module): On windows (cygwin) function asctime_r doesn't
   fprintf(stderr,"%s\n",error_text);    exist so I changed back to asctime which exists.
   exit(1);    (Module): Version 0.96b
 }  
 /*********************** vector *******************/    Revision 1.92  2003/06/25 16:30:45  brouard
 double *vector(int nl, int nh)    (Module): On windows (cygwin) function asctime_r doesn't
 {    exist so I changed back to asctime which exists.
   double *v;  
   v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));    Revision 1.91  2003/06/25 15:30:29  brouard
   if (!v) nrerror("allocation failure in vector");    * imach.c (Repository): Duplicated warning errors corrected.
   return v-nl+NR_END;    (Repository): Elapsed time after each iteration is now output. It
 }    helps to forecast when convergence will be reached. Elapsed time
     is stamped in powell.  We created a new html file for the graphs
 /************************ free vector ******************/    concerning matrix of covariance. It has extension -cov.htm.
 void free_vector(double*v, int nl, int nh)  
 {    Revision 1.90  2003/06/24 12:34:15  brouard
   free((FREE_ARG)(v+nl-NR_END));    (Module): Some bugs corrected for windows. Also, when
 }    mle=-1 a template is output in file "or"mypar.txt with the design
     of the covariance matrix to be input.
 /************************ivector *******************************/  
 int *ivector(long nl,long nh)    Revision 1.89  2003/06/24 12:30:52  brouard
 {    (Module): Some bugs corrected for windows. Also, when
   int *v;    mle=-1 a template is output in file "or"mypar.txt with the design
   v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));    of the covariance matrix to be input.
   if (!v) nrerror("allocation failure in ivector");  
   return v-nl+NR_END;    Revision 1.88  2003/06/23 17:54:56  brouard
 }    * imach.c (Repository): Create a sub-directory where all the secondary files are. Only imach, htm, gp and r(imach) are on the main directory. Correct time and other things.
   
 /******************free ivector **************************/    Revision 1.87  2003/06/18 12:26:01  brouard
 void free_ivector(int *v, long nl, long nh)    Version 0.96
 {  
   free((FREE_ARG)(v+nl-NR_END));    Revision 1.86  2003/06/17 20:04:08  brouard
 }    (Module): Change position of html and gnuplot routines and added
     routine fileappend.
 /******************* imatrix *******************************/  
 int **imatrix(long nrl, long nrh, long ncl, long nch)    Revision 1.85  2003/06/17 13:12:43  brouard
      /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */    * imach.c (Repository): Check when date of death was earlier that
 {    current date of interview. It may happen when the death was just
   long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;    prior to the death. In this case, dh was negative and likelihood
   int **m;    was wrong (infinity). We still send an "Error" but patch by
      assuming that the date of death was just one stepm after the
   /* allocate pointers to rows */    interview.
   m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*)));    (Repository): Because some people have very long ID (first column)
   if (!m) nrerror("allocation failure 1 in matrix()");    we changed int to long in num[] and we added a new lvector for
   m += NR_END;    memory allocation. But we also truncated to 8 characters (left
   m -= nrl;    truncation)
      (Repository): No more line truncation errors.
    
   /* allocate rows and set pointers to them */    Revision 1.84  2003/06/13 21:44:43  brouard
   m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int)));    * imach.c (Repository): Replace "freqsummary" at a correct
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");    place. It differs from routine "prevalence" which may be called
   m[nrl] += NR_END;    many times. Probs is memory consuming and must be used with
   m[nrl] -= ncl;    parcimony.
      Version 0.95a3 (should output exactly the same maximization than 0.8a2)
   for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;  
      Revision 1.83  2003/06/10 13:39:11  lievre
   /* return pointer to array of pointers to rows */    *** empty log message ***
   return m;  
 }    Revision 1.82  2003/06/05 15:57:20  brouard
     Add log in  imach.c and  fullversion number is now printed.
 /****************** free_imatrix *************************/  
 void free_imatrix(m,nrl,nrh,ncl,nch)  */
       int **m;  /*
       long nch,ncl,nrh,nrl;     Interpolated Markov Chain
      /* free an int matrix allocated by imatrix() */  
 {    Short summary of the programme:
   free((FREE_ARG) (m[nrl]+ncl-NR_END));    
   free((FREE_ARG) (m+nrl-NR_END));    This program computes Healthy Life Expectancies from
 }    cross-longitudinal data. Cross-longitudinal data consist in: -1- a
     first survey ("cross") where individuals from different ages are
 /******************* matrix *******************************/    interviewed on their health status or degree of disability (in the
 double **matrix(long nrl, long nrh, long ncl, long nch)    case of a health survey which is our main interest) -2- at least a
 {    second wave of interviews ("longitudinal") which measure each change
   long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;    (if any) in individual health status.  Health expectancies are
   double **m;    computed from the time spent in each health state according to a
     model. More health states you consider, more time is necessary to reach the
   m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));    Maximum Likelihood of the parameters involved in the model.  The
   if (!m) nrerror("allocation failure 1 in matrix()");    simplest model is the multinomial logistic model where pij is the
   m += NR_END;    probability to be observed in state j at the second wave
   m -= nrl;    conditional to be observed in state i at the first wave. Therefore
     the model is: log(pij/pii)= aij + bij*age+ cij*sex + etc , where
   m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));    'age' is age and 'sex' is a covariate. If you want to have a more
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");    complex model than "constant and age", you should modify the program
   m[nrl] += NR_END;    where the markup *Covariates have to be included here again* invites
   m[nrl] -= ncl;    you to do it.  More covariates you add, slower the
     convergence.
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  
   return m;    The advantage of this computer programme, compared to a simple
 }    multinomial logistic model, is clear when the delay between waves is not
     identical for each individual. Also, if a individual missed an
 /*************************free matrix ************************/    intermediate interview, the information is lost, but taken into
 void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)    account using an interpolation or extrapolation.  
 {  
   free((FREE_ARG)(m[nrl]+ncl-NR_END));    hPijx is the probability to be observed in state i at age x+h
   free((FREE_ARG)(m+nrl-NR_END));    conditional to the observed state i at age x. The delay 'h' can be
 }    split into an exact number (nh*stepm) of unobserved intermediate
     states. This elementary transition (by month, quarter,
 /******************* ma3x *******************************/    semester or year) is modelled as a multinomial logistic.  The hPx
 double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)    matrix is simply the matrix product of nh*stepm elementary matrices
 {    and the contribution of each individual to the likelihood is simply
   long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;    hPijx.
   double ***m;  
     Also this programme outputs the covariance matrix of the parameters but also
   m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));    of the life expectancies. It also computes the period (stable) prevalence. 
   if (!m) nrerror("allocation failure 1 in matrix()");    
   m += NR_END;    Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).
   m -= nrl;             Institut national d'études démographiques, Paris.
     This software have been partly granted by Euro-REVES, a concerted action
   m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));    from the European Union.
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");    It is copyrighted identically to a GNU software product, ie programme and
   m[nrl] += NR_END;    software can be distributed freely for non commercial use. Latest version
   m[nrl] -= ncl;    can be accessed at http://euroreves.ined.fr/imach .
   
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;    Help to debug: LD_PRELOAD=/usr/local/lib/libnjamd.so ./imach foo.imach
     or better on gdb : set env LD_PRELOAD=/usr/local/lib/libnjamd.so
   m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));    
   if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");    **********************************************************************/
   m[nrl][ncl] += NR_END;  /*
   m[nrl][ncl] -= nll;    main
   for (j=ncl+1; j<=nch; j++)    read parameterfile
     m[nrl][j]=m[nrl][j-1]+nlay;    read datafile
      concatwav
   for (i=nrl+1; i<=nrh; i++) {    freqsummary
     m[i][ncl]=m[i-1l][ncl]+ncol*nlay;    if (mle >= 1)
     for (j=ncl+1; j<=nch; j++)      mlikeli
       m[i][j]=m[i][j-1]+nlay;    print results files
   }    if mle==1 
   return m;       computes hessian
 }    read end of parameter file: agemin, agemax, bage, fage, estepm
         begin-prev-date,...
 /*************************free ma3x ************************/    open gnuplot file
 void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)    open html file
 {    period (stable) prevalence
   free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));     for age prevalim()
   free((FREE_ARG)(m[nrl]+ncl-NR_END));    h Pij x
   free((FREE_ARG)(m+nrl-NR_END));    variance of p varprob
 }    forecasting if prevfcast==1 prevforecast call prevalence()
     health expectancies
 /***************** f1dim *************************/    Variance-covariance of DFLE
 extern int ncom;    prevalence()
 extern double *pcom,*xicom;     movingaverage()
 extern double (*nrfunc)(double []);    varevsij() 
      if popbased==1 varevsij(,popbased)
 double f1dim(double x)    total life expectancies
 {    Variance of period (stable) prevalence
   int j;   end
   double f;  */
   double *xt;  
    
   xt=vector(1,ncom);  
   for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j];   
   f=(*nrfunc)(xt);  #include <math.h>
   free_vector(xt,1,ncom);  #include <stdio.h>
   return f;  #include <stdlib.h>
 }  #include <string.h>
   #include <unistd.h>
 /*****************brent *************************/  
 double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin)  #include <limits.h>
 {  #include <sys/types.h>
   int iter;  #include <sys/stat.h>
   double a,b,d,etemp;  #include <errno.h>
   double fu,fv,fw,fx;  extern int errno;
   double ftemp;  
   double p,q,r,tol1,tol2,u,v,w,x,xm;  /* #include <sys/time.h> */
   double e=0.0;  #include <time.h>
    #include "timeval.h"
   a=(ax < cx ? ax : cx);  
   b=(ax > cx ? ax : cx);  #ifdef GSL
   x=w=v=bx;  #include <gsl/gsl_errno.h>
   fw=fv=fx=(*f)(x);  #include <gsl/gsl_multimin.h>
   for (iter=1;iter<=ITMAX;iter++) {  #endif
     xm=0.5*(a+b);  
     tol2=2.0*(tol1=tol*fabs(x)+ZEPS);  /* #include <libintl.h> */
     /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/  /* #define _(String) gettext (String) */
     printf(".");fflush(stdout);  
 #ifdef DEBUG  #define MAXLINE 256
     printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);  
     /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */  #define GNUPLOTPROGRAM "gnuplot"
 #endif  /*#define GNUPLOTPROGRAM "..\\gp37mgw\\wgnuplot"*/
     if (fabs(x-xm) <= (tol2-0.5*(b-a))){  #define FILENAMELENGTH 132
       *xmin=x;  
       return fx;  #define GLOCK_ERROR_NOPATH              -1      /* empty path */
     }  #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */
     ftemp=fu;  
     if (fabs(e) > tol1) {  #define MAXPARM 128 /* Maximum number of parameters for the optimization */
       r=(x-w)*(fx-fv);  #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */
       q=(x-v)*(fx-fw);  
       p=(x-v)*q-(x-w)*r;  #define NINTERVMAX 8
       q=2.0*(q-r);  #define NLSTATEMAX 8 /* Maximum number of live states (for func) */
       if (q > 0.0) p = -p;  #define NDEATHMAX 8 /* Maximum number of dead states (for func) */
       q=fabs(q);  #define NCOVMAX 20 /* Maximum number of covariates */
       etemp=e;  #define MAXN 20000
       e=d;  #define YEARM 12. /* Number of months per year */
       if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x))  #define AGESUP 130
         d=CGOLD*(e=(x >= xm ? a-x : b-x));  #define AGEBASE 40
       else {  #define AGEGOMP 10. /* Minimal age for Gompertz adjustment */
         d=p/q;  #ifdef UNIX
         u=x+d;  #define DIRSEPARATOR '/'
         if (u-a < tol2 || b-u < tol2)  #define CHARSEPARATOR "/"
           d=SIGN(tol1,xm-x);  #define ODIRSEPARATOR '\\'
       }  #else
     } else {  #define DIRSEPARATOR '\\'
       d=CGOLD*(e=(x >= xm ? a-x : b-x));  #define CHARSEPARATOR "\\"
     }  #define ODIRSEPARATOR '/'
     u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d));  #endif
     fu=(*f)(u);  
     if (fu <= fx) {  /* $Id$ */
       if (u >= x) a=x; else b=x;  /* $State$ */
       SHFT(v,w,x,u)  
         SHFT(fv,fw,fx,fu)  char version[]="Imach version 0.98m, April 2010, INED-EUROREVES-Institut de longevite ";
         } else {  char fullversion[]="$Revision$ $Date$"; 
           if (u < x) a=u; else b=u;  char strstart[80];
           if (fu <= fw || w == x) {  char optionfilext[10], optionfilefiname[FILENAMELENGTH];
             v=w;  int erreur=0, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings  */
             w=u;  int nvar=0, nforce=0; /* Number of variables, number of forces */
             fv=fw;  int cptcovn=0, cptcovage=0, cptcoveff=0,cptcov=0; /* Number of covariates, of covariates with '*age' */
             fw=fu;  int npar=NPARMAX;
           } else if (fu <= fv || v == x || v == w) {  int nlstate=2; /* Number of live states */
             v=u;  int ndeath=1; /* Number of dead states */
             fv=fu;  int ncovmodel=0, ncovcol=0;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */
           }  int popbased=0;
         }  
   }  int *wav; /* Number of waves for this individuual 0 is possible */
   nrerror("Too many iterations in brent");  int maxwav=0; /* Maxim number of waves */
   *xmin=x;  int jmin=0, jmax=0; /* min, max spacing between 2 waves */
   return fx;  int ijmin=0, ijmax=0; /* Individuals having jmin and jmax */ 
 }  int gipmx=0, gsw=0; /* Global variables on the number of contributions 
                      to the likelihood and the sum of weights (done by funcone)*/
 /****************** mnbrak ***********************/  int mle=1, weightopt=0;
   int **mw; /* mw[mi][i] is number of the mi wave for this individual */
 void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc,  int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */
             double (*func)(double))  int **bh; /* bh[mi][i] is the bias (+ or -) for this individual if the delay between
 {             * wave mi and wave mi+1 is not an exact multiple of stepm. */
   double ulim,u,r,q, dum;  double jmean=1; /* Mean space between 2 waves */
   double fu;  double **oldm, **newm, **savm; /* Working pointers to matrices */
    double **oldms, **newms, **savms; /* Fixed working pointers to matrices */
   *fa=(*func)(*ax);  /*FILE *fic ; */ /* Used in readdata only */
   *fb=(*func)(*bx);  FILE *ficpar, *ficparo,*ficres, *ficresp, *ficrespl, *ficrespij, *ficrest,*ficresf,*ficrespop;
   if (*fb > *fa) {  FILE *ficlog, *ficrespow;
     SHFT(dum,*ax,*bx,dum)  int globpr=0; /* Global variable for printing or not */
       SHFT(dum,*fb,*fa,dum)  double fretone; /* Only one call to likelihood */
       }  long ipmx=0; /* Number of contributions */
   *cx=(*bx)+GOLD*(*bx-*ax);  double sw; /* Sum of weights */
   *fc=(*func)(*cx);  char filerespow[FILENAMELENGTH];
   while (*fb > *fc) {  char fileresilk[FILENAMELENGTH]; /* File of individual contributions to the likelihood */
     r=(*bx-*ax)*(*fb-*fc);  FILE *ficresilk;
     q=(*bx-*cx)*(*fb-*fa);  FILE *ficgp,*ficresprob,*ficpop, *ficresprobcov, *ficresprobcor;
     u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/  FILE *ficresprobmorprev;
       (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r));  FILE *fichtm, *fichtmcov; /* Html File */
     ulim=(*bx)+GLIMIT*(*cx-*bx);  FILE *ficreseij;
     if ((*bx-u)*(u-*cx) > 0.0) {  char filerese[FILENAMELENGTH];
       fu=(*func)(u);  FILE *ficresstdeij;
     } else if ((*cx-u)*(u-ulim) > 0.0) {  char fileresstde[FILENAMELENGTH];
       fu=(*func)(u);  FILE *ficrescveij;
       if (fu < *fc) {  char filerescve[FILENAMELENGTH];
         SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx))  FILE  *ficresvij;
           SHFT(*fb,*fc,fu,(*func)(u))  char fileresv[FILENAMELENGTH];
           }  FILE  *ficresvpl;
     } else if ((u-ulim)*(ulim-*cx) >= 0.0) {  char fileresvpl[FILENAMELENGTH];
       u=ulim;  char title[MAXLINE];
       fu=(*func)(u);  char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];
     } else {  char plotcmd[FILENAMELENGTH], pplotcmd[FILENAMELENGTH];
       u=(*cx)+GOLD*(*cx-*bx);  char tmpout[FILENAMELENGTH],  tmpout2[FILENAMELENGTH]; 
       fu=(*func)(u);  char command[FILENAMELENGTH];
     }  int  outcmd=0;
     SHFT(*ax,*bx,*cx,u)  
       SHFT(*fa,*fb,*fc,fu)  char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], rfileres[FILENAMELENGTH];
       }  
 }  char filelog[FILENAMELENGTH]; /* Log file */
   char filerest[FILENAMELENGTH];
 /*************** linmin ************************/  char fileregp[FILENAMELENGTH];
   char popfile[FILENAMELENGTH];
 int ncom;  
 double *pcom,*xicom;  char optionfilegnuplot[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH], optionfilehtmcov[FILENAMELENGTH] ;
 double (*nrfunc)(double []);  
    struct timeval start_time, end_time, curr_time, last_time, forecast_time;
 void linmin(double p[], double xi[], int n, double *fret,double (*func)(double []))  struct timezone tzp;
 {  extern int gettimeofday();
   double brent(double ax, double bx, double cx,  struct tm tmg, tm, tmf, *gmtime(), *localtime();
                double (*f)(double), double tol, double *xmin);  long time_value;
   double f1dim(double x);  extern long time();
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb,  char strcurr[80], strfor[80];
               double *fc, double (*func)(double));  
   int j;  char *endptr;
   double xx,xmin,bx,ax;  long lval;
   double fx,fb,fa;  double dval;
    
   ncom=n;  #define NR_END 1
   pcom=vector(1,n);  #define FREE_ARG char*
   xicom=vector(1,n);  #define FTOL 1.0e-10
   nrfunc=func;  
   for (j=1;j<=n;j++) {  #define NRANSI 
     pcom[j]=p[j];  #define ITMAX 200 
     xicom[j]=xi[j];  
   }  #define TOL 2.0e-4 
   ax=0.0;  
   xx=1.0;  #define CGOLD 0.3819660 
   mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim);  #define ZEPS 1.0e-10 
   *fret=brent(ax,xx,bx,f1dim,TOL,&xmin);  #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d); 
 #ifdef DEBUG  
   printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);  #define GOLD 1.618034 
 #endif  #define GLIMIT 100.0 
   for (j=1;j<=n;j++) {  #define TINY 1.0e-20 
     xi[j] *= xmin;  
     p[j] += xi[j];  static double maxarg1,maxarg2;
   }  #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))
   free_vector(xicom,1,n);  #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))
   free_vector(pcom,1,n);    
 }  #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))
   #define rint(a) floor(a+0.5)
 /*************** powell ************************/  
 void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret,  static double sqrarg;
             double (*func)(double []))  #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)
 {  #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;} 
   void linmin(double p[], double xi[], int n, double *fret,  int agegomp= AGEGOMP;
               double (*func)(double []));  
   int i,ibig,j;  int imx; 
   double del,t,*pt,*ptt,*xit;  int stepm=1;
   double fp,fptt;  /* Stepm, step in month: minimum step interpolation*/
   double *xits;  
   pt=vector(1,n);  int estepm;
   ptt=vector(1,n);  /* Estepm, step in month to interpolate survival function in order to approximate Life Expectancy*/
   xit=vector(1,n);  
   xits=vector(1,n);  int m,nb;
   *fret=(*func)(p);  long *num;
   for (j=1;j<=n;j++) pt[j]=p[j];  int firstpass=0, lastpass=4,*cod, *ncodemax, *Tage,*cens;
   for (*iter=1;;++(*iter)) {  double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;
     fp=(*fret);  double **pmmij, ***probs;
     ibig=0;  double *ageexmed,*agecens;
     del=0.0;  double dateintmean=0;
     printf("\nPowell iter=%d -2*LL=%.12f",*iter,*fret);  
     for (i=1;i<=n;i++)  double *weight;
       printf(" %d %.12f",i, p[i]);  int **s; /* Status */
     printf("\n");  double *agedc, **covar, idx;
     for (i=1;i<=n;i++) {  int **nbcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;
       for (j=1;j<=n;j++) xit[j]=xi[j][i];  double *lsurv, *lpop, *tpop;
       fptt=(*fret);  
 #ifdef DEBUG  double ftol=FTOL; /* Tolerance for computing Max Likelihood */
       printf("fret=%lf \n",*fret);  double ftolhess; /* Tolerance for computing hessian */
 #endif  
       printf("%d",i);fflush(stdout);  /**************** split *************************/
       linmin(p,xit,n,fret,func);  static  int split( char *path, char *dirc, char *name, char *ext, char *finame )
       if (fabs(fptt-(*fret)) > del) {  {
         del=fabs(fptt-(*fret));    /* From a file name with (full) path (either Unix or Windows) we extract the directory (dirc)
         ibig=i;       the name of the file (name), its extension only (ext) and its first part of the name (finame)
       }    */ 
 #ifdef DEBUG    char  *ss;                            /* pointer */
       printf("%d %.12e",i,(*fret));    int   l1, l2;                         /* length counters */
       for (j=1;j<=n;j++) {  
         xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);    l1 = strlen(path );                   /* length of path */
         printf(" x(%d)=%.12e",j,xit[j]);    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );
       }    ss= strrchr( path, DIRSEPARATOR );            /* find last / */
       for(j=1;j<=n;j++)    if ( ss == NULL ) {                   /* no directory, so determine current directory */
         printf(" p=%.12e",p[j]);      strcpy( name, path );               /* we got the fullname name because no directory */
       printf("\n");      /*if(strrchr(path, ODIRSEPARATOR )==NULL)
 #endif        printf("Warning you should use %s as a separator\n",DIRSEPARATOR);*/
     }      /* get current working directory */
     if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {      /*    extern  char* getcwd ( char *buf , int len);*/
 #ifdef DEBUG      if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {
       int k[2],l;        return( GLOCK_ERROR_GETCWD );
       k[0]=1;      }
       k[1]=-1;      /* got dirc from getcwd*/
       printf("Max: %.12e",(*func)(p));      printf(" DIRC = %s \n",dirc);
       for (j=1;j<=n;j++)    } else {                              /* strip direcotry from path */
         printf(" %.12e",p[j]);      ss++;                               /* after this, the filename */
       printf("\n");      l2 = strlen( ss );                  /* length of filename */
       for(l=0;l<=1;l++) {      if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );
         for (j=1;j<=n;j++) {      strcpy( name, ss );         /* save file name */
           ptt[j]=p[j]+(p[j]-pt[j])*k[l];      strncpy( dirc, path, l1 - l2 );     /* now the directory */
           printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);      dirc[l1-l2] = 0;                    /* add zero */
         }      printf(" DIRC2 = %s \n",dirc);
         printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));    }
       }    /* We add a separator at the end of dirc if not exists */
 #endif    l1 = strlen( dirc );                  /* length of directory */
     if( dirc[l1-1] != DIRSEPARATOR ){
       dirc[l1] =  DIRSEPARATOR;
       free_vector(xit,1,n);      dirc[l1+1] = 0; 
       free_vector(xits,1,n);      printf(" DIRC3 = %s \n",dirc);
       free_vector(ptt,1,n);    }
       free_vector(pt,1,n);    ss = strrchr( name, '.' );            /* find last / */
       return;    if (ss >0){
     }      ss++;
     if (*iter == ITMAX) nrerror("powell exceeding maximum iterations.");      strcpy(ext,ss);                     /* save extension */
     for (j=1;j<=n;j++) {      l1= strlen( name);
       ptt[j]=2.0*p[j]-pt[j];      l2= strlen(ss)+1;
       xit[j]=p[j]-pt[j];      strncpy( finame, name, l1-l2);
       pt[j]=p[j];      finame[l1-l2]= 0;
     }    }
     fptt=(*func)(ptt);  
     if (fptt < fp) {    return( 0 );                          /* we're done */
       t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt);  }
       if (t < 0.0) {  
         linmin(p,xit,n,fret,func);  
         for (j=1;j<=n;j++) {  /******************************************/
           xi[j][ibig]=xi[j][n];  
           xi[j][n]=xit[j];  void replace_back_to_slash(char *s, char*t)
         }  {
 #ifdef DEBUG    int i;
         printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);    int lg=0;
         for(j=1;j<=n;j++)    i=0;
           printf(" %.12e",xit[j]);    lg=strlen(t);
         printf("\n");    for(i=0; i<= lg; i++) {
 #endif      (s[i] = t[i]);
       }      if (t[i]== '\\') s[i]='/';
     }    }
   }  }
 }  
   char *trimbb(char *out, char *in)
 /**** Prevalence limit ****************/  { /* Trim multiple blanks in line but keeps first blanks if line starts with blanks */
     char *s;
 double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)    s=out;
 {    while (*in != '\0'){
   /* Computes the prevalence limit in each live state at age x by left multiplying the unit      while( *in == ' ' && *(in+1) == ' '){ /* && *(in+1) != '\0'){*/
      matrix by transitions matrix until convergence is reached */        in++;
       }
   int i, ii,j,k;      *out++ = *in++;
   double min, max, maxmin, maxmax,sumnew=0.;    }
   double **matprod2();    *out='\0';
   double **out, cov[NCOVMAX], **pmij();    return s;
   double **newm;  }
   double agefin, delaymax=50 ; /* Max number of years to converge */  
   char *cutv(char *blocc, char *alocc, char *in, char occ)
   for (ii=1;ii<=nlstate+ndeath;ii++)  {
     for (j=1;j<=nlstate+ndeath;j++){    /* cuts string in into blocc and alocc where blocc ends before last occurence of char 'occ' 
       oldm[ii][j]=(ii==j ? 1.0 : 0.0);       and alocc starts after last occurence of char 'occ' : ex cutv(blocc,alocc,"abcdef2ghi2j",'2')
     }       gives blocc="abcdef2ghi" and alocc="j".
        If occ is not found blocc is null and alocc is equal to in. Returns alocc
    cov[1]=1.;    */
      char *s, *t;
  /* Even if hstepm = 1, at least one multiplication by the unit matrix */    t=in;s=in;
   for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){    while (*in != '\0'){
     newm=savm;      while( *in == occ){
     /* Covariates have to be included here again */        *blocc++ = *in++;
      cov[2]=agefin;        s=in;
        }
       for (k=1; k<=cptcovn;k++) {      *blocc++ = *in++;
         cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];    }
         /*printf("ij=%d Tvar[k]=%d nbcode=%d cov=%lf\n",ij, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k]);*/    if (s == t) /* occ not found */
       }      *(blocc-(in-s))='\0';
       for (k=1; k<=cptcovage;k++)    else
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];      *(blocc-(in-s)-1)='\0';
       for (k=1; k<=cptcovprod;k++)    in=s;
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];    while ( *in != '\0'){
       *alocc++ = *in++;
       /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/    }
   
       /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/    *alocc='\0';
     return s;
     out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);  }
   
     savm=oldm;  int nbocc(char *s, char occ)
     oldm=newm;  {
     maxmax=0.;    int i,j=0;
     for(j=1;j<=nlstate;j++){    int lg=20;
       min=1.;    i=0;
       max=0.;    lg=strlen(s);
       for(i=1; i<=nlstate; i++) {    for(i=0; i<= lg; i++) {
         sumnew=0;    if  (s[i] == occ ) j++;
         for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];    }
         prlim[i][j]= newm[i][j]/(1-sumnew);    return j;
         max=FMAX(max,prlim[i][j]);  }
         min=FMIN(min,prlim[i][j]);  
       }  /* void cutv(char *u,char *v, char*t, char occ) */
       maxmin=max-min;  /* { */
       maxmax=FMAX(maxmax,maxmin);  /*   /\* cuts string t into u and v where u ends before last occurence of char 'occ'  */
     }  /*      and v starts after last occurence of char 'occ' : ex cutv(u,v,"abcdef2ghi2j",'2') */
     if(maxmax < ftolpl){  /*      gives u="abcdef2ghi" and v="j" *\/ */
       return prlim;  /*   int i,lg,j,p=0; */
     }  /*   i=0; */
   }  /*   lg=strlen(t); */
 }  /*   for(j=0; j<=lg-1; j++) { */
   /*     if((t[j]!= occ) && (t[j+1]== occ)) p=j+1; */
 /*************** transition probabilities **********/  /*   } */
   
 double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )  /*   for(j=0; j<p; j++) { */
 {  /*     (u[j] = t[j]); */
   double s1, s2;  /*   } */
   /*double t34;*/  /*      u[p]='\0'; */
   int i,j,j1, nc, ii, jj;  
   /*    for(j=0; j<= lg; j++) { */
     for(i=1; i<= nlstate; i++){  /*     if (j>=(p+1))(v[j-p-1] = t[j]); */
     for(j=1; j<i;j++){  /*   } */
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){  /* } */
         /*s2 += param[i][j][nc]*cov[nc];*/  
         s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];  /********************** nrerror ********************/
         /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/  
       }  void nrerror(char error_text[])
       ps[i][j]=s2;  {
       /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/    fprintf(stderr,"ERREUR ...\n");
     }    fprintf(stderr,"%s\n",error_text);
     for(j=i+1; j<=nlstate+ndeath;j++){    exit(EXIT_FAILURE);
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){  }
         s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];  /*********************** vector *******************/
         /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/  double *vector(int nl, int nh)
       }  {
       ps[i][j]=s2;    double *v;
     }    v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));
   }    if (!v) nrerror("allocation failure in vector");
   for(i=1; i<= nlstate; i++){    return v-nl+NR_END;
      s1=0;  }
     for(j=1; j<i; j++)  
       s1+=exp(ps[i][j]);  /************************ free vector ******************/
     for(j=i+1; j<=nlstate+ndeath; j++)  void free_vector(double*v, int nl, int nh)
       s1+=exp(ps[i][j]);  {
     ps[i][i]=1./(s1+1.);    free((FREE_ARG)(v+nl-NR_END));
     for(j=1; j<i; j++)  }
       ps[i][j]= exp(ps[i][j])*ps[i][i];  
     for(j=i+1; j<=nlstate+ndeath; j++)  /************************ivector *******************************/
       ps[i][j]= exp(ps[i][j])*ps[i][i];  int *ivector(long nl,long nh)
     /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */  {
   } /* end i */    int *v;
     v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));
   for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){    if (!v) nrerror("allocation failure in ivector");
     for(jj=1; jj<= nlstate+ndeath; jj++){    return v-nl+NR_END;
       ps[ii][jj]=0;  }
       ps[ii][ii]=1;  
     }  /******************free ivector **************************/
   }  void free_ivector(int *v, long nl, long nh)
   {
   /*   for(ii=1; ii<= nlstate+ndeath; ii++){    free((FREE_ARG)(v+nl-NR_END));
     for(jj=1; jj<= nlstate+ndeath; jj++){  }
      printf("%lf ",ps[ii][jj]);  
    }  /************************lvector *******************************/
     printf("\n ");  long *lvector(long nl,long nh)
     }  {
     printf("\n ");printf("%lf ",cov[2]);*/    long *v;
 /*    v=(long *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(long)));
   for(i=1; i<= npar; i++) printf("%f ",x[i]);    if (!v) nrerror("allocation failure in ivector");
   goto end;*/    return v-nl+NR_END;
     return ps;  }
 }  
   /******************free lvector **************************/
 /**************** Product of 2 matrices ******************/  void free_lvector(long *v, long nl, long nh)
   {
 double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)    free((FREE_ARG)(v+nl-NR_END));
 {  }
   /* Computes the matric product of in(1,nrh-nrl+1)(1,nch-ncl+1) times  
      b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */  /******************* imatrix *******************************/
   /* in, b, out are matrice of pointers which should have been initialized  int **imatrix(long nrl, long nrh, long ncl, long nch) 
      before: only the contents of out is modified. The function returns       /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */ 
      a pointer to pointers identical to out */  { 
   long i, j, k;    long i, nrow=nrh-nrl+1,ncol=nch-ncl+1; 
   for(i=nrl; i<= nrh; i++)    int **m; 
     for(k=ncolol; k<=ncoloh; k++)    
       for(j=ncl,out[i][k]=0.; j<=nch; j++)    /* allocate pointers to rows */ 
         out[i][k] +=in[i][j]*b[j][k];    m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*))); 
     if (!m) nrerror("allocation failure 1 in matrix()"); 
   return out;    m += NR_END; 
 }    m -= nrl; 
     
     
 /************* Higher Matrix Product ***************/    /* allocate rows and set pointers to them */ 
     m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int))); 
 double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )    if (!m[nrl]) nrerror("allocation failure 2 in matrix()"); 
 {    m[nrl] += NR_END; 
   /* Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' month    m[nrl] -= ncl; 
      duration (i.e. until    
      age (in years)  age+nhstepm*stepm/12) by multiplying nhstepm*hstepm matrices.    for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol; 
      Output is stored in matrix po[i][j][h] for h every 'hstepm' step    
      (typically every 2 years instead of every month which is too big).    /* return pointer to array of pointers to rows */ 
      Model is determined by parameters x and covariates have to be    return m; 
      included manually here.  } 
   
      */  /****************** free_imatrix *************************/
   void free_imatrix(m,nrl,nrh,ncl,nch)
   int i, j, d, h, k;        int **m;
   double **out, cov[NCOVMAX];        long nch,ncl,nrh,nrl; 
   double **newm;       /* free an int matrix allocated by imatrix() */ 
   { 
   /* Hstepm could be zero and should return the unit matrix */    free((FREE_ARG) (m[nrl]+ncl-NR_END)); 
   for (i=1;i<=nlstate+ndeath;i++)    free((FREE_ARG) (m+nrl-NR_END)); 
     for (j=1;j<=nlstate+ndeath;j++){  } 
       oldm[i][j]=(i==j ? 1.0 : 0.0);  
       po[i][j][0]=(i==j ? 1.0 : 0.0);  /******************* matrix *******************************/
     }  double **matrix(long nrl, long nrh, long ncl, long nch)
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */  {
   for(h=1; h <=nhstepm; h++){    long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;
     for(d=1; d <=hstepm; d++){    double **m;
       newm=savm;  
       /* Covariates have to be included here again */    m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
       cov[1]=1.;    if (!m) nrerror("allocation failure 1 in matrix()");
       cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;    m += NR_END;
       for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];    m -= nrl;
 for (k=1; k<=cptcovage;k++)  
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];    m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
    for (k=1; k<=cptcovprod;k++)    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];    m[nrl] += NR_END;
     m[nrl] -= ncl;
   
       /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
       /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/    return m;
       out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath,    /* print *(*(m+1)+70) or print m[1][70]; print m+1 or print &(m[1]) 
                    pmij(pmmij,cov,ncovmodel,x,nlstate));     */
       savm=oldm;  }
       oldm=newm;  
     }  /*************************free matrix ************************/
     for(i=1; i<=nlstate+ndeath; i++)  void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)
       for(j=1;j<=nlstate+ndeath;j++) {  {
         po[i][j][h]=newm[i][j];    free((FREE_ARG)(m[nrl]+ncl-NR_END));
         /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);    free((FREE_ARG)(m+nrl-NR_END));
          */  }
       }  
   } /* end h */  /******************* ma3x *******************************/
   return po;  double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)
 }  {
     long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;
     double ***m;
 /*************** log-likelihood *************/  
 double func( double *x)    m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
 {    if (!m) nrerror("allocation failure 1 in matrix()");
   int i, ii, j, k, mi, d, kk;    m += NR_END;
   double l, ll[NLSTATEMAX], cov[NCOVMAX];    m -= nrl;
   double **out;  
   double sw; /* Sum of weights */    m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
   double lli; /* Individual log likelihood */    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
   long ipmx;    m[nrl] += NR_END;
   /*extern weight */    m[nrl] -= ncl;
   /* We are differentiating ll according to initial status */  
   /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
   /*for(i=1;i<imx;i++)  
 printf(" %d\n",s[4][i]);    m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));
   */    if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");
   cov[1]=1.;    m[nrl][ncl] += NR_END;
     m[nrl][ncl] -= nll;
   for(k=1; k<=nlstate; k++) ll[k]=0.;    for (j=ncl+1; j<=nch; j++) 
   for (i=1,ipmx=0, sw=0.; i<=imx; i++){      m[nrl][j]=m[nrl][j-1]+nlay;
     for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];    
        for(mi=1; mi<= wav[i]-1; mi++){    for (i=nrl+1; i<=nrh; i++) {
       for (ii=1;ii<=nlstate+ndeath;ii++)      m[i][ncl]=m[i-1l][ncl]+ncol*nlay;
         for (j=1;j<=nlstate+ndeath;j++) oldm[ii][j]=(ii==j ? 1.0 : 0.0);      for (j=ncl+1; j<=nch; j++) 
             for(d=0; d<dh[mi][i]; d++){        m[i][j]=m[i][j-1]+nlay;
               newm=savm;    }
               cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;    return m; 
               for (kk=1; kk<=cptcovage;kk++) {    /*  gdb: p *(m+1) <=> p m[1] and p (m+1) <=> p (m+1) <=> p &(m[1])
                  cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];             &(m[i][j][k]) <=> *((*(m+i) + j)+k)
                  /*printf("%d %d",kk,Tage[kk]);*/    */
               }  }
               /*cov[4]=covar[1][i]*cov[2];scanf("%d", i);*/  
               /*cov[3]=pow(cov[2],2)/1000.;*/  /*************************free ma3x ************************/
   void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)
           out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,  {
                        1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));    free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));
           savm=oldm;    free((FREE_ARG)(m[nrl]+ncl-NR_END));
           oldm=newm;    free((FREE_ARG)(m+nrl-NR_END));
   }
   
       } /* end mult */  /*************** function subdirf ***********/
      char *subdirf(char fileres[])
       lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);  {
       /* printf(" %f ",out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/    /* Caution optionfilefiname is hidden */
       ipmx +=1;    strcpy(tmpout,optionfilefiname);
       sw += weight[i];    strcat(tmpout,"/"); /* Add to the right */
       ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;    strcat(tmpout,fileres);
     } /* end of wave */    return tmpout;
   } /* end of individual */  }
   
   for(k=1,l=0.; k<=nlstate; k++) l += ll[k];  /*************** function subdirf2 ***********/
   /* printf("l1=%f l2=%f ",ll[1],ll[2]); */  char *subdirf2(char fileres[], char *preop)
   l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */  {
   return -l;    
 }    /* Caution optionfilefiname is hidden */
     strcpy(tmpout,optionfilefiname);
     strcat(tmpout,"/");
 /*********** Maximum Likelihood Estimation ***************/    strcat(tmpout,preop);
     strcat(tmpout,fileres);
 void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))    return tmpout;
 {  }
   int i,j, iter;  
   double **xi,*delti;  /*************** function subdirf3 ***********/
   double fret;  char *subdirf3(char fileres[], char *preop, char *preop2)
   xi=matrix(1,npar,1,npar);  {
   for (i=1;i<=npar;i++)    
     for (j=1;j<=npar;j++)    /* Caution optionfilefiname is hidden */
       xi[i][j]=(i==j ? 1.0 : 0.0);    strcpy(tmpout,optionfilefiname);
   printf("Powell\n");    strcat(tmpout,"/");
   powell(p,xi,npar,ftol,&iter,&fret,func);    strcat(tmpout,preop);
     strcat(tmpout,preop2);
    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));    strcat(tmpout,fileres);
   fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f ",iter,func(p));    return tmpout;
   }
 }  
   /***************** f1dim *************************/
 /**** Computes Hessian and covariance matrix ***/  extern int ncom; 
 void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))  extern double *pcom,*xicom;
 {  extern double (*nrfunc)(double []); 
   double  **a,**y,*x,pd;   
   double **hess;  double f1dim(double x) 
   int i, j,jk;  { 
   int *indx;    int j; 
     double f;
   double hessii(double p[], double delta, int theta, double delti[]);    double *xt; 
   double hessij(double p[], double delti[], int i, int j);   
   void lubksb(double **a, int npar, int *indx, double b[]) ;    xt=vector(1,ncom); 
   void ludcmp(double **a, int npar, int *indx, double *d) ;    for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j]; 
     f=(*nrfunc)(xt); 
     free_vector(xt,1,ncom); 
   hess=matrix(1,npar,1,npar);    return f; 
   } 
   printf("\nCalculation of the hessian matrix. Wait...\n");  
   for (i=1;i<=npar;i++){  /*****************brent *************************/
     printf("%d",i);fflush(stdout);  double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin) 
     hess[i][i]=hessii(p,ftolhess,i,delti);  { 
     /*printf(" %f ",p[i]);*/    int iter; 
   }    double a,b,d,etemp;
     double fu,fv,fw,fx;
   for (i=1;i<=npar;i++) {    double ftemp;
     for (j=1;j<=npar;j++)  {    double p,q,r,tol1,tol2,u,v,w,x,xm; 
       if (j>i) {    double e=0.0; 
         printf(".%d%d",i,j);fflush(stdout);   
         hess[i][j]=hessij(p,delti,i,j);    a=(ax < cx ? ax : cx); 
         hess[j][i]=hess[i][j];    b=(ax > cx ? ax : cx); 
       }    x=w=v=bx; 
     }    fw=fv=fx=(*f)(x); 
   }    for (iter=1;iter<=ITMAX;iter++) { 
   printf("\n");      xm=0.5*(a+b); 
       tol2=2.0*(tol1=tol*fabs(x)+ZEPS); 
   printf("\nInverting the hessian to get the covariance matrix. Wait...\n");      /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/
        printf(".");fflush(stdout);
   a=matrix(1,npar,1,npar);      fprintf(ficlog,".");fflush(ficlog);
   y=matrix(1,npar,1,npar);  #ifdef DEBUG
   x=vector(1,npar);      printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
   indx=ivector(1,npar);      fprintf(ficlog,"br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
   for (i=1;i<=npar;i++)      /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */
     for (j=1;j<=npar;j++) a[i][j]=hess[i][j];  #endif
   ludcmp(a,npar,indx,&pd);      if (fabs(x-xm) <= (tol2-0.5*(b-a))){ 
         *xmin=x; 
   for (j=1;j<=npar;j++) {        return fx; 
     for (i=1;i<=npar;i++) x[i]=0;      } 
     x[j]=1;      ftemp=fu;
     lubksb(a,npar,indx,x);      if (fabs(e) > tol1) { 
     for (i=1;i<=npar;i++){        r=(x-w)*(fx-fv); 
       matcov[i][j]=x[i];        q=(x-v)*(fx-fw); 
     }        p=(x-v)*q-(x-w)*r; 
   }        q=2.0*(q-r); 
         if (q > 0.0) p = -p; 
   printf("\n#Hessian matrix#\n");        q=fabs(q); 
   for (i=1;i<=npar;i++) {        etemp=e; 
     for (j=1;j<=npar;j++) {        e=d; 
       printf("%.3e ",hess[i][j]);        if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x)) 
     }          d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
     printf("\n");        else { 
   }          d=p/q; 
           u=x+d; 
   /* Recompute Inverse */          if (u-a < tol2 || b-u < tol2) 
   for (i=1;i<=npar;i++)            d=SIGN(tol1,xm-x); 
     for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];        } 
   ludcmp(a,npar,indx,&pd);      } else { 
         d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
   /*  printf("\n#Hessian matrix recomputed#\n");      } 
       u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d)); 
   for (j=1;j<=npar;j++) {      fu=(*f)(u); 
     for (i=1;i<=npar;i++) x[i]=0;      if (fu <= fx) { 
     x[j]=1;        if (u >= x) a=x; else b=x; 
     lubksb(a,npar,indx,x);        SHFT(v,w,x,u) 
     for (i=1;i<=npar;i++){          SHFT(fv,fw,fx,fu) 
       y[i][j]=x[i];          } else { 
       printf("%.3e ",y[i][j]);            if (u < x) a=u; else b=u; 
     }            if (fu <= fw || w == x) { 
     printf("\n");              v=w; 
   }              w=u; 
   */              fv=fw; 
               fw=fu; 
   free_matrix(a,1,npar,1,npar);            } else if (fu <= fv || v == x || v == w) { 
   free_matrix(y,1,npar,1,npar);              v=u; 
   free_vector(x,1,npar);              fv=fu; 
   free_ivector(indx,1,npar);            } 
   free_matrix(hess,1,npar,1,npar);          } 
     } 
     nrerror("Too many iterations in brent"); 
 }    *xmin=x; 
     return fx; 
 /*************** hessian matrix ****************/  } 
 double hessii( double x[], double delta, int theta, double delti[])  
 {  /****************** mnbrak ***********************/
   int i;  
   int l=1, lmax=20;  void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc, 
   double k1,k2;              double (*func)(double)) 
   double p2[NPARMAX+1];  { 
   double res;    double ulim,u,r,q, dum;
   double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;    double fu; 
   double fx;   
   int k=0,kmax=10;    *fa=(*func)(*ax); 
   double l1;    *fb=(*func)(*bx); 
     if (*fb > *fa) { 
   fx=func(x);      SHFT(dum,*ax,*bx,dum) 
   for (i=1;i<=npar;i++) p2[i]=x[i];        SHFT(dum,*fb,*fa,dum) 
   for(l=0 ; l <=lmax; l++){        } 
     l1=pow(10,l);    *cx=(*bx)+GOLD*(*bx-*ax); 
     delts=delt;    *fc=(*func)(*cx); 
     for(k=1 ; k <kmax; k=k+1){    while (*fb > *fc) { 
       delt = delta*(l1*k);      r=(*bx-*ax)*(*fb-*fc); 
       p2[theta]=x[theta] +delt;      q=(*bx-*cx)*(*fb-*fa); 
       k1=func(p2)-fx;      u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/ 
       p2[theta]=x[theta]-delt;        (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r)); 
       k2=func(p2)-fx;      ulim=(*bx)+GLIMIT*(*cx-*bx); 
       /*res= (k1-2.0*fx+k2)/delt/delt; */      if ((*bx-u)*(u-*cx) > 0.0) { 
       res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */        fu=(*func)(u); 
            } else if ((*cx-u)*(u-ulim) > 0.0) { 
 #ifdef DEBUG        fu=(*func)(u); 
       printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);        if (fu < *fc) { 
 #endif          SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx)) 
       /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */            SHFT(*fb,*fc,fu,(*func)(u)) 
       if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){            } 
         k=kmax;      } else if ((u-ulim)*(ulim-*cx) >= 0.0) { 
       }        u=ulim; 
       else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */        fu=(*func)(u); 
         k=kmax; l=lmax*10.;      } else { 
       }        u=(*cx)+GOLD*(*cx-*bx); 
       else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){        fu=(*func)(u); 
         delts=delt;      } 
       }      SHFT(*ax,*bx,*cx,u) 
     }        SHFT(*fa,*fb,*fc,fu) 
   }        } 
   delti[theta]=delts;  } 
   return res;  
    /*************** linmin ************************/
 }  
   int ncom; 
 double hessij( double x[], double delti[], int thetai,int thetaj)  double *pcom,*xicom;
 {  double (*nrfunc)(double []); 
   int i;   
   int l=1, l1, lmax=20;  void linmin(double p[], double xi[], int n, double *fret,double (*func)(double [])) 
   double k1,k2,k3,k4,res,fx;  { 
   double p2[NPARMAX+1];    double brent(double ax, double bx, double cx, 
   int k;                 double (*f)(double), double tol, double *xmin); 
     double f1dim(double x); 
   fx=func(x);    void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, 
   for (k=1; k<=2; k++) {                double *fc, double (*func)(double)); 
     for (i=1;i<=npar;i++) p2[i]=x[i];    int j; 
     p2[thetai]=x[thetai]+delti[thetai]/k;    double xx,xmin,bx,ax; 
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;    double fx,fb,fa;
     k1=func(p2)-fx;   
      ncom=n; 
     p2[thetai]=x[thetai]+delti[thetai]/k;    pcom=vector(1,n); 
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;    xicom=vector(1,n); 
     k2=func(p2)-fx;    nrfunc=func; 
      for (j=1;j<=n;j++) { 
     p2[thetai]=x[thetai]-delti[thetai]/k;      pcom[j]=p[j]; 
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;      xicom[j]=xi[j]; 
     k3=func(p2)-fx;    } 
      ax=0.0; 
     p2[thetai]=x[thetai]-delti[thetai]/k;    xx=1.0; 
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;    mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim); 
     k4=func(p2)-fx;    *fret=brent(ax,xx,bx,f1dim,TOL,&xmin); 
     res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */  #ifdef DEBUG
 #ifdef DEBUG    printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
     printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);    fprintf(ficlog,"retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
 #endif  #endif
   }    for (j=1;j<=n;j++) { 
   return res;      xi[j] *= xmin; 
 }      p[j] += xi[j]; 
     } 
 /************** Inverse of matrix **************/    free_vector(xicom,1,n); 
 void ludcmp(double **a, int n, int *indx, double *d)    free_vector(pcom,1,n); 
 {  } 
   int i,imax,j,k;  
   double big,dum,sum,temp;  char *asc_diff_time(long time_sec, char ascdiff[])
   double *vv;  {
      long sec_left, days, hours, minutes;
   vv=vector(1,n);    days = (time_sec) / (60*60*24);
   *d=1.0;    sec_left = (time_sec) % (60*60*24);
   for (i=1;i<=n;i++) {    hours = (sec_left) / (60*60) ;
     big=0.0;    sec_left = (sec_left) %(60*60);
     for (j=1;j<=n;j++)    minutes = (sec_left) /60;
       if ((temp=fabs(a[i][j])) > big) big=temp;    sec_left = (sec_left) % (60);
     if (big == 0.0) nrerror("Singular matrix in routine ludcmp");    sprintf(ascdiff,"%d day(s) %d hour(s) %d minute(s) %d second(s)",days, hours, minutes, sec_left);  
     vv[i]=1.0/big;    return ascdiff;
   }  }
   for (j=1;j<=n;j++) {  
     for (i=1;i<j;i++) {  /*************** powell ************************/
       sum=a[i][j];  void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret, 
       for (k=1;k<i;k++) sum -= a[i][k]*a[k][j];              double (*func)(double [])) 
       a[i][j]=sum;  { 
     }    void linmin(double p[], double xi[], int n, double *fret, 
     big=0.0;                double (*func)(double [])); 
     for (i=j;i<=n;i++) {    int i,ibig,j; 
       sum=a[i][j];    double del,t,*pt,*ptt,*xit;
       for (k=1;k<j;k++)    double fp,fptt;
         sum -= a[i][k]*a[k][j];    double *xits;
       a[i][j]=sum;    int niterf, itmp;
       if ( (dum=vv[i]*fabs(sum)) >= big) {  
         big=dum;    pt=vector(1,n); 
         imax=i;    ptt=vector(1,n); 
       }    xit=vector(1,n); 
     }    xits=vector(1,n); 
     if (j != imax) {    *fret=(*func)(p); 
       for (k=1;k<=n;k++) {    for (j=1;j<=n;j++) pt[j]=p[j]; 
         dum=a[imax][k];    for (*iter=1;;++(*iter)) { 
         a[imax][k]=a[j][k];      fp=(*fret); 
         a[j][k]=dum;      ibig=0; 
       }      del=0.0; 
       *d = -(*d);      last_time=curr_time;
       vv[imax]=vv[j];      (void) gettimeofday(&curr_time,&tzp);
     }      printf("\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);fflush(stdout);
     indx[j]=imax;      fprintf(ficlog,"\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec); fflush(ficlog);
     if (a[j][j] == 0.0) a[j][j]=TINY;  /*     fprintf(ficrespow,"%d %.12f %ld",*iter,*fret,curr_time.tv_sec-start_time.tv_sec); */
     if (j != n) {     for (i=1;i<=n;i++) {
       dum=1.0/(a[j][j]);        printf(" %d %.12f",i, p[i]);
       for (i=j+1;i<=n;i++) a[i][j] *= dum;        fprintf(ficlog," %d %.12lf",i, p[i]);
     }        fprintf(ficrespow," %.12lf", p[i]);
   }      }
   free_vector(vv,1,n);  /* Doesn't work */      printf("\n");
 ;      fprintf(ficlog,"\n");
 }      fprintf(ficrespow,"\n");fflush(ficrespow);
       if(*iter <=3){
 void lubksb(double **a, int n, int *indx, double b[])        tm = *localtime(&curr_time.tv_sec);
 {        strcpy(strcurr,asctime(&tm));
   int i,ii=0,ip,j;  /*       asctime_r(&tm,strcurr); */
   double sum;        forecast_time=curr_time; 
          itmp = strlen(strcurr);
   for (i=1;i<=n;i++) {        if(strcurr[itmp-1]=='\n')  /* Windows outputs with a new line */
     ip=indx[i];          strcurr[itmp-1]='\0';
     sum=b[ip];        printf("\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
     b[ip]=b[i];        fprintf(ficlog,"\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
     if (ii)        for(niterf=10;niterf<=30;niterf+=10){
       for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j];          forecast_time.tv_sec=curr_time.tv_sec+(niterf-*iter)*(curr_time.tv_sec-last_time.tv_sec);
     else if (sum) ii=i;          tmf = *localtime(&forecast_time.tv_sec);
     b[i]=sum;  /*      asctime_r(&tmf,strfor); */
   }          strcpy(strfor,asctime(&tmf));
   for (i=n;i>=1;i--) {          itmp = strlen(strfor);
     sum=b[i];          if(strfor[itmp-1]=='\n')
     for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j];          strfor[itmp-1]='\0';
     b[i]=sum/a[i][i];          printf("   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   }          fprintf(ficlog,"   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
 }        }
       }
 /************ Frequencies ********************/      for (i=1;i<=n;i++) { 
 void  freqsummary(char fileres[], int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax)        for (j=1;j<=n;j++) xit[j]=xi[j][i]; 
 {  /* Some frequencies */        fptt=(*fret); 
    #ifdef DEBUG
   int i, m, jk, k1, i1, j1, bool, z1,z2,j;        printf("fret=%lf \n",*fret);
   double ***freq; /* Frequencies */        fprintf(ficlog,"fret=%lf \n",*fret);
   double *pp;  #endif
   double pos;        printf("%d",i);fflush(stdout);
   FILE *ficresp;        fprintf(ficlog,"%d",i);fflush(ficlog);
   char fileresp[FILENAMELENGTH];        linmin(p,xit,n,fret,func); 
         if (fabs(fptt-(*fret)) > del) { 
   pp=vector(1,nlstate);          del=fabs(fptt-(*fret)); 
           ibig=i; 
   strcpy(fileresp,"p");        } 
   strcat(fileresp,fileres);  #ifdef DEBUG
   if((ficresp=fopen(fileresp,"w"))==NULL) {        printf("%d %.12e",i,(*fret));
     printf("Problem with prevalence resultfile: %s\n", fileresp);        fprintf(ficlog,"%d %.12e",i,(*fret));
     exit(0);        for (j=1;j<=n;j++) {
   }          xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);
   freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);          printf(" x(%d)=%.12e",j,xit[j]);
   j1=0;          fprintf(ficlog," x(%d)=%.12e",j,xit[j]);
         }
   j=cptcoveff;        for(j=1;j<=n;j++) {
   if (cptcovn<1) {j=1;ncodemax[1]=1;}          printf(" p=%.12e",p[j]);
           fprintf(ficlog," p=%.12e",p[j]);
   for(k1=1; k1<=j;k1++){        }
    for(i1=1; i1<=ncodemax[k1];i1++){        printf("\n");
        j1++;        fprintf(ficlog,"\n");
   #endif
         for (i=-1; i<=nlstate+ndeath; i++)        } 
          for (jk=-1; jk<=nlstate+ndeath; jk++)        if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {
            for(m=agemin; m <= agemax+3; m++)  #ifdef DEBUG
              freq[i][jk][m]=0;        int k[2],l;
                k[0]=1;
        for (i=1; i<=imx; i++) {        k[1]=-1;
          bool=1;        printf("Max: %.12e",(*func)(p));
          if  (cptcovn>0) {        fprintf(ficlog,"Max: %.12e",(*func)(p));
            for (z1=1; z1<=cptcoveff; z1++)        for (j=1;j<=n;j++) {
              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) bool=0;          printf(" %.12e",p[j]);
          }          fprintf(ficlog," %.12e",p[j]);
           if (bool==1) {        }
            for(m=firstpass; m<=lastpass-1; m++){        printf("\n");
              if(agev[m][i]==0) agev[m][i]=agemax+1;        fprintf(ficlog,"\n");
              if(agev[m][i]==1) agev[m][i]=agemax+2;        for(l=0;l<=1;l++) {
              freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];          for (j=1;j<=n;j++) {
              freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];            ptt[j]=p[j]+(p[j]-pt[j])*k[l];
            }            printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
          }            fprintf(ficlog,"l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
        }          }
         if  (cptcovn>0) {          printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
          fprintf(ficresp, "\n#********** Variable ");          fprintf(ficlog,"func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);        }
        }  #endif
        fprintf(ficresp, "**********\n#");  
        for(i=1; i<=nlstate;i++)  
          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);        free_vector(xit,1,n); 
        fprintf(ficresp, "\n");        free_vector(xits,1,n); 
                free_vector(ptt,1,n); 
   for(i=(int)agemin; i <= (int)agemax+3; i++){        free_vector(pt,1,n); 
     if(i==(int)agemax+3)        return; 
       printf("Total");      } 
     else      if (*iter == ITMAX) nrerror("powell exceeding maximum iterations."); 
       printf("Age %d", i);      for (j=1;j<=n;j++) { 
     for(jk=1; jk <=nlstate ; jk++){        ptt[j]=2.0*p[j]-pt[j]; 
       for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)        xit[j]=p[j]-pt[j]; 
         pp[jk] += freq[jk][m][i];        pt[j]=p[j]; 
     }      } 
     for(jk=1; jk <=nlstate ; jk++){      fptt=(*func)(ptt); 
       for(m=-1, pos=0; m <=0 ; m++)      if (fptt < fp) { 
         pos += freq[jk][m][i];        t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt); 
       if(pp[jk]>=1.e-10)        if (t < 0.0) { 
         printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);          linmin(p,xit,n,fret,func); 
       else          for (j=1;j<=n;j++) { 
         printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);            xi[j][ibig]=xi[j][n]; 
     }            xi[j][n]=xit[j]; 
     for(jk=1; jk <=nlstate ; jk++){          }
       for(m=1, pp[jk]=0; m <=nlstate+ndeath; m++)  #ifdef DEBUG
         pp[jk] += freq[jk][m][i];          printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
     }          fprintf(ficlog,"Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
     for(jk=1,pos=0; jk <=nlstate ; jk++)          for(j=1;j<=n;j++){
       pos += pp[jk];            printf(" %.12e",xit[j]);
     for(jk=1; jk <=nlstate ; jk++){            fprintf(ficlog," %.12e",xit[j]);
       if(pos>=1.e-5)          }
         printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);          printf("\n");
       else          fprintf(ficlog,"\n");
         printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);  #endif
       if( i <= (int) agemax){        }
         if(pos>=1.e-5)      } 
           fprintf(ficresp," %d %.5f %.0f %.0f",i,pp[jk]/pos, pp[jk],pos);    } 
       else  } 
           fprintf(ficresp," %d NaNq %.0f %.0f",i,pp[jk],pos);  
       }  /**** Prevalence limit (stable or period prevalence)  ****************/
     }  
     for(jk=-1; jk <=nlstate+ndeath; jk++)  double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)
       for(m=-1; m <=nlstate+ndeath; m++)  {
         if(freq[jk][m][i] !=0 ) printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);    /* Computes the prevalence limit in each live state at age x by left multiplying the unit
     if(i <= (int) agemax)       matrix by transitions matrix until convergence is reached */
       fprintf(ficresp,"\n");  
     printf("\n");    int i, ii,j,k;
     }    double min, max, maxmin, maxmax,sumnew=0.;
     }    double **matprod2();
  }    double **out, cov[NCOVMAX+1], **pmij();
      double **newm;
   fclose(ficresp);    double agefin, delaymax=50 ; /* Max number of years to converge */
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);  
   free_vector(pp,1,nlstate);    for (ii=1;ii<=nlstate+ndeath;ii++)
       for (j=1;j<=nlstate+ndeath;j++){
 }  /* End of Freq */        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       }
 /************* Waves Concatenation ***************/  
      cov[1]=1.;
 void  concatwav(int wav[], int **dh, int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)   
 {   /* Even if hstepm = 1, at least one multiplication by the unit matrix */
   /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.    for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){
      Death is a valid wave (if date is known).      newm=savm;
      mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i      /* Covariates have to be included here again */
      dh[m][i] of dh[mw[mi][i][i] is the delay between two effective waves m=mw[mi][i]      cov[2]=agefin;
      and mw[mi+1][i]. dh depends on stepm.      
      */      for (k=1; k<=cptcovn;k++) {
         cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
   int i, mi, m;        /*        printf("ij=%d k=%d Tvar[k]=%d nbcode=%d cov=%lf codtab[ij][Tvar[k]]=%d \n",ij,k, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k], codtab[ij][Tvar[k]]);*/
   int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;      }
 float sum=0.;      for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
       for (k=1; k<=cptcovprod;k++)
   for(i=1; i<=imx; i++){        cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]] * nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
     mi=0;      
     m=firstpass;      /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/
     while(s[m][i] <= nlstate){      /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/
       if(s[m][i]>=1)      /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/
         mw[++mi][i]=m;      out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);
       if(m >=lastpass)      
         break;      savm=oldm;
       else      oldm=newm;
         m++;      maxmax=0.;
     }/* end while */      for(j=1;j<=nlstate;j++){
     if (s[m][i] > nlstate){        min=1.;
       mi++;     /* Death is another wave */        max=0.;
       /* if(mi==0)  never been interviewed correctly before death */        for(i=1; i<=nlstate; i++) {
          /* Only death is a correct wave */          sumnew=0;
       mw[mi][i]=m;          for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];
     }          prlim[i][j]= newm[i][j]/(1-sumnew);
           max=FMAX(max,prlim[i][j]);
     wav[i]=mi;          min=FMIN(min,prlim[i][j]);
     if(mi==0)        }
       printf("Warning, no any valid information for:%d line=%d\n",num[i],i);        maxmin=max-min;
   }        maxmax=FMAX(maxmax,maxmin);
       }
   for(i=1; i<=imx; i++){      if(maxmax < ftolpl){
     for(mi=1; mi<wav[i];mi++){        return prlim;
       if (stepm <=0)      }
         dh[mi][i]=1;    }
       else{  }
         if (s[mw[mi+1][i]][i] > nlstate) {  
           j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12);  /*************** transition probabilities ***************/ 
           if(j=0) j=1;  /* Survives at least one month after exam */  
         }  double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )
         else{  {
           j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));    /* According to parameters values stored in x and the covariate's values stored in cov,
           k=k+1;       computes the probability to be observed in state j being in state i by appying the
           if (j >= jmax) jmax=j;       model to the ncovmodel covariates (including constant and age).
           else if (j <= jmin)jmin=j;       lnpijopii=ln(pij/pii)= aij+bij*age+cij*v1+dij*v2+... = sum_nc=1^ncovmodel xij(nc)*cov[nc]
           sum=sum+j;       and, according on how parameters are entered, the position of the coefficient xij(nc) of the
         }       ncth covariate in the global vector x is given by the formula:
         jk= j/stepm;       j<i nc+((i-1)*(nlstate+ndeath-1)+j-1)*ncovmodel
         jl= j -jk*stepm;       j>=i nc + ((i-1)*(nlstate+ndeath-1)+(j-2))*ncovmodel
         ju= j -(jk+1)*stepm;       Computes ln(pij/pii) (lnpijopii), deduces pij/pii by exponentiation,
         if(jl <= -ju)       sums on j different of i to get 1-pii/pii, deduces pii, and then all pij.
           dh[mi][i]=jk;       Outputs ps[i][j] the probability to be observed in j being in j according to
         else       the values of the covariates cov[nc] and corresponding parameter values x[nc+shiftij]
           dh[mi][i]=jk+1;    */
         if(dh[mi][i]==0)    double s1, lnpijopii;
           dh[mi][i]=1; /* At least one step */    /*double t34;*/
       }    int i,j,j1, nc, ii, jj;
     }  
   }      for(i=1; i<= nlstate; i++){
   printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,sum/k);        for(j=1; j<i;j++){
 }          for (nc=1, lnpijopii=0.;nc <=ncovmodel; nc++){
 /*********** Tricode ****************************/            /*lnpijopii += param[i][j][nc]*cov[nc];*/
 void tricode(int *Tvar, int **nbcode, int imx)            lnpijopii += x[nc+((i-1)*(nlstate+ndeath-1)+j-1)*ncovmodel]*cov[nc];
 {  /*       printf("Int j<i s1=%.17e, lnpijopii=%.17e\n",s1,lnpijopii); */
   int Ndum[20],ij=1, k, j, i;          }
   int cptcode=0;          ps[i][j]=lnpijopii; /* In fact ln(pij/pii) */
   cptcoveff=0;  /*      printf("s1=%.17e, lnpijopii=%.17e\n",s1,lnpijopii); */
          }
   for (k=0; k<19; k++) Ndum[k]=0;        for(j=i+1; j<=nlstate+ndeath;j++){
   for (k=1; k<=7; k++) ncodemax[k]=0;          for (nc=1, lnpijopii=0.;nc <=ncovmodel; nc++){
             /*lnpijopii += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];*/
   for (j=1; j<=(cptcovn+2*cptcovprod); j++) {            lnpijopii += x[nc + ((i-1)*(nlstate+ndeath-1)+(j-2))*ncovmodel]*cov[nc];
     for (i=1; i<=imx; i++) {  /*        printf("Int j>i s1=%.17e, lnpijopii=%.17e %lx %lx\n",s1,lnpijopii,s1,lnpijopii); */
       ij=(int)(covar[Tvar[j]][i]);          }
       Ndum[ij]++;          ps[i][j]=lnpijopii; /* In fact ln(pij/pii) */
       if (ij > cptcode) cptcode=ij;        }
     }      }
       
     /*printf("cptcode=%d cptcovn=%d ",cptcode,cptcovn);*/      for(i=1; i<= nlstate; i++){
     for (i=0; i<=cptcode; i++) {        s1=0;
       if(Ndum[i]!=0) ncodemax[j]++;        for(j=1; j<i; j++){
     }          s1+=exp(ps[i][j]); /* In fact sums pij/pii */
     ij=1;          /*printf("debug1 %d %d ps=%lf exp(ps)=%lf s1+=%lf\n",i,j,ps[i][j],exp(ps[i][j]),s1); */
         }
     for (i=1; i<=ncodemax[j]; i++) {        for(j=i+1; j<=nlstate+ndeath; j++){
       for (k=0; k<=19; k++) {          s1+=exp(ps[i][j]); /* In fact sums pij/pii */
         if (Ndum[k] != 0) {          /*printf("debug2 %d %d ps=%lf exp(ps)=%lf s1+=%lf\n",i,j,ps[i][j],exp(ps[i][j]),s1); */
           nbcode[Tvar[j]][ij]=k;        }
           /*   printf("ij=%d ",nbcode[Tvar[2]][1]);*/        /* s1= sum_{j<>i} pij/pii=(1-pii)/pii and thus pii is known from s1 */
           ij++;        ps[i][i]=1./(s1+1.);
         }        /* Computing other pijs */
         if (ij > ncodemax[j]) break;        for(j=1; j<i; j++)
       }            ps[i][j]= exp(ps[i][j])*ps[i][i];
     }        for(j=i+1; j<=nlstate+ndeath; j++)
   }            ps[i][j]= exp(ps[i][j])*ps[i][i];
  for (i=1; i<=10; i++) {        /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */
       ij=Tvar[i];      } /* end i */
       Ndum[ij]++;      
     }      for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){
  ij=1;        for(jj=1; jj<= nlstate+ndeath; jj++){
  for (i=1; i<=cptcovn; i++) {          ps[ii][jj]=0;
    if((Ndum[i]!=0) && (i<=ncov)){          ps[ii][ii]=1;
      Tvaraff[i]=ij;        }
    ij++;      }
    }      
  }  
    /*        for(ii=1; ii<= nlstate+ndeath; ii++){ */
  for (j=1; j<=(cptcovn+2*cptcovprod); j++) {  /*       for(jj=1; jj<= nlstate+ndeath; jj++){ */
    if ((Tvar[j]>= cptcoveff) && (Tvar[j] <=ncov)) cptcoveff=Tvar[j];  /*         printf("ddd %lf ",ps[ii][jj]); */
    /*printf("j=%d %d\n",j,Tvar[j]);*/  /*       } */
  }  /*       printf("\n "); */
    /*        } */
  /* printf("cptcoveff=%d Tvaraff=%d %d\n",cptcoveff, Tvaraff[1],Tvaraff[2]);  /*        printf("\n ");printf("%lf ",cov[2]); */
     scanf("%d",i);*/         /*
 }        for(i=1; i<= npar; i++) printf("%f ",x[i]);
         goto end;*/
 /*********** Health Expectancies ****************/      return ps;
   }
 void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij)  
 {  /**************** Product of 2 matrices ******************/
   /* Health expectancies */  
   int i, j, nhstepm, hstepm, h;  double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)
   double age, agelim,hf;  {
   double ***p3mat;    /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times
         b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */
   fprintf(ficreseij,"# Health expectancies\n");    /* in, b, out are matrice of pointers which should have been initialized 
   fprintf(ficreseij,"# Age");       before: only the contents of out is modified. The function returns
   for(i=1; i<=nlstate;i++)       a pointer to pointers identical to out */
     for(j=1; j<=nlstate;j++)    long i, j, k;
       fprintf(ficreseij," %1d-%1d",i,j);    for(i=nrl; i<= nrh; i++)
   fprintf(ficreseij,"\n");      for(k=ncolol; k<=ncoloh; k++)
         for(j=ncl,out[i][k]=0.; j<=nch; j++)
   hstepm=1*YEARM; /*  Every j years of age (in month) */          out[i][k] +=in[i][j]*b[j][k];
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */  
     return out;
   agelim=AGESUP;  }
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */  
     /* nhstepm age range expressed in number of stepm */  
     nhstepm=(int) rint((agelim-age)*YEARM/stepm);  /************* Higher Matrix Product ***************/
     /* Typically if 20 years = 20*12/6=40 stepm */  
     if (stepm >= YEARM) hstepm=1;  double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )
     nhstepm = nhstepm/hstepm;/* Expressed in hstepm, typically 40/4=10 */  {
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    /* Computes the transition matrix starting at age 'age' over 
     /* Computed by stepm unit matrices, product of hstepm matrices, stored       'nhstepm*hstepm*stepm' months (i.e. until
        in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */       age (in years)  age+nhstepm*hstepm*stepm/12) by multiplying 
     hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);         nhstepm*hstepm matrices. 
        Output is stored in matrix po[i][j][h] for h every 'hstepm' step 
        (typically every 2 years instead of every month which is too big 
     for(i=1; i<=nlstate;i++)       for the memory).
       for(j=1; j<=nlstate;j++)       Model is determined by parameters x and covariates have to be 
         for (h=0, eij[i][j][(int)age]=0; h<=nhstepm; h++){       included manually here. 
           eij[i][j][(int)age] +=p3mat[i][j][h];  
         }       */
      
     hf=1;    int i, j, d, h, k;
     if (stepm >= YEARM) hf=stepm/YEARM;    double **out, cov[NCOVMAX+1];
     fprintf(ficreseij,"%.0f",age );    double **newm;
     for(i=1; i<=nlstate;i++)  
       for(j=1; j<=nlstate;j++){    /* Hstepm could be zero and should return the unit matrix */
         fprintf(ficreseij," %.4f", hf*eij[i][j][(int)age]);    for (i=1;i<=nlstate+ndeath;i++)
       }      for (j=1;j<=nlstate+ndeath;j++){
     fprintf(ficreseij,"\n");        oldm[i][j]=(i==j ? 1.0 : 0.0);
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);        po[i][j][0]=(i==j ? 1.0 : 0.0);
   }      }
 }    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
     for(h=1; h <=nhstepm; h++){
 /************ Variance ******************/      for(d=1; d <=hstepm; d++){
 void varevsij(char fileres[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)        newm=savm;
 {        /* Covariates have to be included here again */
   /* Variance of health expectancies */        cov[1]=1.;
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/        cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;
   double **newm;        for (k=1; k<=cptcovn;k++) 
   double **dnewm,**doldm;          cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
   int i, j, nhstepm, hstepm, h;        for (k=1; k<=cptcovage;k++)
   int k, cptcode;          cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
    double *xp;        for (k=1; k<=cptcovprod;k++)
   double **gp, **gm;          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
   double ***gradg, ***trgradg;  
   double ***p3mat;  
   double age,agelim;        /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/
   int theta;        /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/
         out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, 
    fprintf(ficresvij,"# Covariances of life expectancies\n");                     pmij(pmmij,cov,ncovmodel,x,nlstate));
   fprintf(ficresvij,"# Age");        savm=oldm;
   for(i=1; i<=nlstate;i++)        oldm=newm;
     for(j=1; j<=nlstate;j++)      }
       fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);      for(i=1; i<=nlstate+ndeath; i++)
   fprintf(ficresvij,"\n");        for(j=1;j<=nlstate+ndeath;j++) {
           po[i][j][h]=newm[i][j];
   xp=vector(1,npar);          /*if(h==nhstepm) printf("po[%d][%d][%d]=%f ",i,j,h,po[i][j][h]);*/
   dnewm=matrix(1,nlstate,1,npar);        }
   doldm=matrix(1,nlstate,1,nlstate);      /*printf("h=%d ",h);*/
      } /* end h */
   hstepm=1*YEARM; /* Every year of age */  /*     printf("\n H=%d \n",h); */
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */    return po;
   agelim = AGESUP;  }
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */  
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */  
     if (stepm >= YEARM) hstepm=1;  /*************** log-likelihood *************/
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */  double func( double *x)
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);  {
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate);    int i, ii, j, k, mi, d, kk;
     gp=matrix(0,nhstepm,1,nlstate);    double l, ll[NLSTATEMAX+1], cov[NCOVMAX+1];
     gm=matrix(0,nhstepm,1,nlstate);    double **out;
     double sw; /* Sum of weights */
     for(theta=1; theta <=npar; theta++){    double lli; /* Individual log likelihood */
       for(i=1; i<=npar; i++){ /* Computes gradient */    int s1, s2;
         xp[i] = x[i] + (i==theta ?delti[theta]:0);    double bbh, survp;
       }    long ipmx;
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);      /*extern weight */
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    /* We are differentiating ll according to initial status */
       for(j=1; j<= nlstate; j++){    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
         for(h=0; h<=nhstepm; h++){    /*for(i=1;i<imx;i++) 
           for(i=1, gp[h][j]=0.;i<=nlstate;i++)      printf(" %d\n",s[4][i]);
             gp[h][j] += prlim[i][i]*p3mat[i][j][h];    */
         }    cov[1]=1.;
       }  
        for(k=1; k<=nlstate; k++) ll[k]=0.;
       for(i=1; i<=npar; i++) /* Computes gradient */  
         xp[i] = x[i] - (i==theta ?delti[theta]:0);    if(mle==1){
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);        for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);        /* Computes the values of the ncovmodel covariates of the model
       for(j=1; j<= nlstate; j++){           depending if the covariates are fixed or variying (age dependent) and stores them in cov[]
         for(h=0; h<=nhstepm; h++){           Then computes with function pmij which return a matrix p[i][j] giving the elementary probability
           for(i=1, gm[h][j]=0.;i<=nlstate;i++)           to be observed in j being in i according to the model.
             gm[h][j] += prlim[i][i]*p3mat[i][j][h];         */
         }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
       }        /* In model V2+V1*V4+age*V3+V3*V2 Tvar[1] is V2, Tvar[2=V1*V4] 
       for(j=1; j<= nlstate; j++)           is 6, Tvar[3=age*V3] should not be computed because of age Tvar[4=V3*V2] 
         for(h=0; h<=nhstepm; h++){           has been calculated etc */
           gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];        for(mi=1; mi<= wav[i]-1; mi++){
         }          for (ii=1;ii<=nlstate+ndeath;ii++)
     } /* End theta */            for (j=1;j<=nlstate+ndeath;j++){
               oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     trgradg =ma3x(0,nhstepm,1,nlstate,1,npar);              savm[ii][j]=(ii==j ? 1.0 : 0.0);
             }
     for(h=0; h<=nhstepm; h++)          for(d=0; d<dh[mi][i]; d++){
       for(j=1; j<=nlstate;j++)            newm=savm;
         for(theta=1; theta <=npar; theta++)            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
           trgradg[h][j][theta]=gradg[h][theta][j];            for (kk=1; kk<=cptcovage;kk++) {
               cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2]; /* Tage[kk] gives the data-covariate associated with age */
     for(i=1;i<=nlstate;i++)            }
       for(j=1;j<=nlstate;j++)            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
         vareij[i][j][(int)age] =0.;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
     for(h=0;h<=nhstepm;h++){            savm=oldm;
       for(k=0;k<=nhstepm;k++){            oldm=newm;
         matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);          } /* end mult */
         matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);        
         for(i=1;i<=nlstate;i++)          /*lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/ /* Original formula */
           for(j=1;j<=nlstate;j++)          /* But now since version 0.9 we anticipate for bias at large stepm.
             vareij[i][j][(int)age] += doldm[i][j];           * If stepm is larger than one month (smallest stepm) and if the exact delay 
       }           * (in months) between two waves is not a multiple of stepm, we rounded to 
     }           * the nearest (and in case of equal distance, to the lowest) interval but now
     h=1;           * we keep into memory the bias bh[mi][i] and also the previous matrix product
     if (stepm >= YEARM) h=stepm/YEARM;           * (i.e to dh[mi][i]-1) saved in 'savm'. Then we inter(extra)polate the
     fprintf(ficresvij,"%.0f ",age );           * probability in order to take into account the bias as a fraction of the way
     for(i=1; i<=nlstate;i++)           * from savm to out if bh is negative or even beyond if bh is positive. bh varies
       for(j=1; j<=nlstate;j++){           * -stepm/2 to stepm/2 .
         fprintf(ficresvij," %.4f", h*vareij[i][j][(int)age]);           * For stepm=1 the results are the same as for previous versions of Imach.
       }           * For stepm > 1 the results are less biased than in previous versions. 
     fprintf(ficresvij,"\n");           */
     free_matrix(gp,0,nhstepm,1,nlstate);          s1=s[mw[mi][i]][i];
     free_matrix(gm,0,nhstepm,1,nlstate);          s2=s[mw[mi+1][i]][i];
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);          bbh=(double)bh[mi][i]/(double)stepm; 
     free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);          /* bias bh is positive if real duration
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);           * is higher than the multiple of stepm and negative otherwise.
   } /* End age */           */
            /* lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2]));*/
   free_vector(xp,1,npar);          if( s2 > nlstate){ 
   free_matrix(doldm,1,nlstate,1,npar);            /* i.e. if s2 is a death state and if the date of death is known 
   free_matrix(dnewm,1,nlstate,1,nlstate);               then the contribution to the likelihood is the probability to 
                die between last step unit time and current  step unit time, 
 }               which is also equal to probability to die before dh 
                minus probability to die before dh-stepm . 
 /************ Variance of prevlim ******************/               In version up to 0.92 likelihood was computed
 void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)          as if date of death was unknown. Death was treated as any other
 {          health state: the date of the interview describes the actual state
   /* Variance of prevalence limit */          and not the date of a change in health state. The former idea was
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/          to consider that at each interview the state was recorded
   double **newm;          (healthy, disable or death) and IMaCh was corrected; but when we
   double **dnewm,**doldm;          introduced the exact date of death then we should have modified
   int i, j, nhstepm, hstepm;          the contribution of an exact death to the likelihood. This new
   int k, cptcode;          contribution is smaller and very dependent of the step unit
   double *xp;          stepm. It is no more the probability to die between last interview
   double *gp, *gm;          and month of death but the probability to survive from last
   double **gradg, **trgradg;          interview up to one month before death multiplied by the
   double age,agelim;          probability to die within a month. Thanks to Chris
   int theta;          Jackson for correcting this bug.  Former versions increased
              mortality artificially. The bad side is that we add another loop
   fprintf(ficresvpl,"# Standard deviation of prevalences limit\n");          which slows down the processing. The difference can be up to 10%
   fprintf(ficresvpl,"# Age");          lower mortality.
   for(i=1; i<=nlstate;i++)            */
       fprintf(ficresvpl," %1d-%1d",i,i);            lli=log(out[s1][s2] - savm[s1][s2]);
   fprintf(ficresvpl,"\n");  
   
   xp=vector(1,npar);          } else if  (s2==-2) {
   dnewm=matrix(1,nlstate,1,npar);            for (j=1,survp=0. ; j<=nlstate; j++) 
   doldm=matrix(1,nlstate,1,nlstate);              survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
              /*survp += out[s1][j]; */
   hstepm=1*YEARM; /* Every year of age */            lli= log(survp);
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */          }
   agelim = AGESUP;          
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */          else if  (s2==-4) { 
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */            for (j=3,survp=0. ; j<=nlstate; j++)  
     if (stepm >= YEARM) hstepm=1;              survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */            lli= log(survp); 
     gradg=matrix(1,npar,1,nlstate);          } 
     gp=vector(1,nlstate);  
     gm=vector(1,nlstate);          else if  (s2==-5) { 
             for (j=1,survp=0. ; j<=2; j++)  
     for(theta=1; theta <=npar; theta++){              survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
       for(i=1; i<=npar; i++){ /* Computes gradient */            lli= log(survp); 
         xp[i] = x[i] + (i==theta ?delti[theta]:0);          } 
       }          
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);          else{
       for(i=1;i<=nlstate;i++)            lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
         gp[i] = prlim[i][i];            /*  lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2]));*/ /* linear interpolation */
              } 
       for(i=1; i<=npar; i++) /* Computes gradient */          /*lli=(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]);*/
         xp[i] = x[i] - (i==theta ?delti[theta]:0);          /*if(lli ==000.0)*/
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);          /*printf("bbh= %f lli=%f savm=%f out=%f %d\n",bbh,lli,savm[s1][s2], out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]],i); */
       for(i=1;i<=nlstate;i++)          ipmx +=1;
         gm[i] = prlim[i][i];          sw += weight[i];
           ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       for(i=1;i<=nlstate;i++)        } /* end of wave */
         gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];      } /* end of individual */
     } /* End theta */    }  else if(mle==2){
       for (i=1,ipmx=0, sw=0.; i<=imx; i++){
     trgradg =matrix(1,nlstate,1,npar);        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
         for(mi=1; mi<= wav[i]-1; mi++){
     for(j=1; j<=nlstate;j++)          for (ii=1;ii<=nlstate+ndeath;ii++)
       for(theta=1; theta <=npar; theta++)            for (j=1;j<=nlstate+ndeath;j++){
         trgradg[j][theta]=gradg[theta][j];              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
               savm[ii][j]=(ii==j ? 1.0 : 0.0);
     for(i=1;i<=nlstate;i++)            }
       varpl[i][(int)age] =0.;          for(d=0; d<=dh[mi][i]; d++){
     matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);            newm=savm;
     matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     for(i=1;i<=nlstate;i++)            for (kk=1; kk<=cptcovage;kk++) {
       varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
             }
     fprintf(ficresvpl,"%.0f ",age );            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     for(i=1; i<=nlstate;i++)                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));            savm=oldm;
     fprintf(ficresvpl,"\n");            oldm=newm;
     free_vector(gp,1,nlstate);          } /* end mult */
     free_vector(gm,1,nlstate);        
     free_matrix(gradg,1,npar,1,nlstate);          s1=s[mw[mi][i]][i];
     free_matrix(trgradg,1,nlstate,1,npar);          s2=s[mw[mi+1][i]][i];
   } /* End age */          bbh=(double)bh[mi][i]/(double)stepm; 
           lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
   free_vector(xp,1,npar);          ipmx +=1;
   free_matrix(doldm,1,nlstate,1,npar);          sw += weight[i];
   free_matrix(dnewm,1,nlstate,1,nlstate);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         } /* end of wave */
 }      } /* end of individual */
     }  else if(mle==3){  /* exponential inter-extrapolation */
       for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
 /***********************************************/        for(mi=1; mi<= wav[i]-1; mi++){
 /**************** Main Program *****************/          for (ii=1;ii<=nlstate+ndeath;ii++)
 /***********************************************/            for (j=1;j<=nlstate+ndeath;j++){
               oldm[ii][j]=(ii==j ? 1.0 : 0.0);
 /*int main(int argc, char *argv[])*/              savm[ii][j]=(ii==j ? 1.0 : 0.0);
 int main()            }
 {          for(d=0; d<dh[mi][i]; d++){
             newm=savm;
   int i,j, k, n=MAXN,iter,m,size,cptcode, aaa, cptcod;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   double agedeb, agefin,hf;            for (kk=1; kk<=cptcovage;kk++) {
   double agemin=1.e20, agemax=-1.e20;              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
             }
   double fret;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   double **xi,tmp,delta;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
             savm=oldm;
   double dum; /* Dummy variable */            oldm=newm;
   double ***p3mat;          } /* end mult */
   int *indx;        
   char line[MAXLINE], linepar[MAXLINE];          s1=s[mw[mi][i]][i];
   char title[MAXLINE];          s2=s[mw[mi+1][i]][i];
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];          bbh=(double)bh[mi][i]/(double)stepm; 
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH];          lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
   char filerest[FILENAMELENGTH];          ipmx +=1;
   char fileregp[FILENAMELENGTH];          sw += weight[i];
   char path[80],pathc[80],pathcd[80],pathtot[80],model[20];          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   int firstobs=1, lastobs=10;        } /* end of wave */
   int sdeb, sfin; /* Status at beginning and end */      } /* end of individual */
   int c,  h , cpt,l;    }else if (mle==4){  /* ml=4 no inter-extrapolation */
   int ju,jl, mi;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
   int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,**adl,*tab;        for(mi=1; mi<= wav[i]-1; mi++){
            for (ii=1;ii<=nlstate+ndeath;ii++)
   int hstepm, nhstepm;            for (j=1;j<=nlstate+ndeath;j++){
   double bage, fage, age, agelim, agebase;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   double ftolpl=FTOL;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
   double **prlim;            }
   double *severity;          for(d=0; d<dh[mi][i]; d++){
   double ***param; /* Matrix of parameters */            newm=savm;
   double  *p;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   double **matcov; /* Matrix of covariance */            for (kk=1; kk<=cptcovage;kk++) {
   double ***delti3; /* Scale */              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
   double *delti; /* Scale */            }
   double ***eij, ***vareij;          
   double **varpl; /* Variances of prevalence limits by age */            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   double *epj, vepp;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   char version[80]="Imach version 62c, May 1999, INED-EUROREVES ";            savm=oldm;
   char *alph[]={"a","a","b","c","d","e"}, str[4];            oldm=newm;
           } /* end mult */
   char z[1]="c", occ;        
 #include <sys/time.h>          s1=s[mw[mi][i]][i];
 #include <time.h>          s2=s[mw[mi+1][i]][i];
   char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];          if( s2 > nlstate){ 
   /* long total_usecs;            lli=log(out[s1][s2] - savm[s1][s2]);
   struct timeval start_time, end_time;          }else{
              lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */          }
           ipmx +=1;
           sw += weight[i];
   printf("\nIMACH, Version 0.64a");          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   printf("\nEnter the parameter file name: ");  /*      printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
         } /* end of wave */
 #ifdef windows      } /* end of individual */
   scanf("%s",pathtot);    }else{  /* ml=5 no inter-extrapolation no jackson =0.8a */
   getcwd(pathcd, size);      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
   /*cygwin_split_path(pathtot,path,optionfile);        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/        for(mi=1; mi<= wav[i]-1; mi++){
   /* cutv(path,optionfile,pathtot,'\\');*/          for (ii=1;ii<=nlstate+ndeath;ii++)
             for (j=1;j<=nlstate+ndeath;j++){
 split(pathtot, path,optionfile);              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   chdir(path);              savm[ii][j]=(ii==j ? 1.0 : 0.0);
   replace(pathc,path);            }
 #endif          for(d=0; d<dh[mi][i]; d++){
 #ifdef unix            newm=savm;
   scanf("%s",optionfile);            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
 #endif            for (kk=1; kk<=cptcovage;kk++) {
               cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
 /*-------- arguments in the command line --------*/            }
           
   strcpy(fileres,"r");            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   strcat(fileres, optionfile);                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
             savm=oldm;
   /*---------arguments file --------*/            oldm=newm;
           } /* end mult */
   if((ficpar=fopen(optionfile,"r"))==NULL)    {        
     printf("Problem with optionfile %s\n",optionfile);          s1=s[mw[mi][i]][i];
     goto end;          s2=s[mw[mi+1][i]][i];
   }          lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
           ipmx +=1;
   strcpy(filereso,"o");          sw += weight[i];
   strcat(filereso,fileres);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   if((ficparo=fopen(filereso,"w"))==NULL) {          /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]);*/
     printf("Problem with Output resultfile: %s\n", filereso);goto end;        } /* end of wave */
   }      } /* end of individual */
     } /* End of if */
   /* Reads comments: lines beginning with '#' */    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
   while((c=getc(ficpar))=='#' && c!= EOF){    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
     ungetc(c,ficpar);    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
     fgets(line, MAXLINE, ficpar);    return -l;
     puts(line);  }
     fputs(line,ficparo);  
   }  /*************** log-likelihood *************/
   ungetc(c,ficpar);  double funcone( double *x)
   {
   fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncov, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);    /* Same as likeli but slower because of a lot of printf and if */
   printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate,ndeath, maxwav, mle, weightopt,model);    int i, ii, j, k, mi, d, kk;
   fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncov,nlstate,ndeath,maxwav, mle, weightopt,model);    double l, ll[NLSTATEMAX+1], cov[NCOVMAX+1];
     double **out;
   covar=matrix(0,NCOVMAX,1,n);        double lli; /* Individual log likelihood */
   if (strlen(model)<=1) cptcovn=0;    double llt;
   else {    int s1, s2;
     j=0;    double bbh, survp;
     j=nbocc(model,'+');    /*extern weight */
     cptcovn=j+1;    /* We are differentiating ll according to initial status */
   }    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
     /*for(i=1;i<imx;i++) 
   ncovmodel=2+cptcovn;      printf(" %d\n",s[4][i]);
   nvar=ncovmodel-1; /* Suppressing age as a basic covariate */    */
      cov[1]=1.;
   /* Read guess parameters */  
   /* Reads comments: lines beginning with '#' */    for(k=1; k<=nlstate; k++) ll[k]=0.;
   while((c=getc(ficpar))=='#' && c!= EOF){  
     ungetc(c,ficpar);    for (i=1,ipmx=0, sw=0.; i<=imx; i++){
     fgets(line, MAXLINE, ficpar);      for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     puts(line);      for(mi=1; mi<= wav[i]-1; mi++){
     fputs(line,ficparo);        for (ii=1;ii<=nlstate+ndeath;ii++)
   }          for (j=1;j<=nlstate+ndeath;j++){
   ungetc(c,ficpar);            oldm[ii][j]=(ii==j ? 1.0 : 0.0);
              savm[ii][j]=(ii==j ? 1.0 : 0.0);
   param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);          }
     for(i=1; i <=nlstate; i++)        for(d=0; d<dh[mi][i]; d++){
     for(j=1; j <=nlstate+ndeath-1; j++){          newm=savm;
       fscanf(ficpar,"%1d%1d",&i1,&j1);          cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
       fprintf(ficparo,"%1d%1d",i1,j1);          for (kk=1; kk<=cptcovage;kk++) {
       printf("%1d%1d",i,j);            cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       for(k=1; k<=ncovmodel;k++){          }
         fscanf(ficpar," %lf",&param[i][j][k]);          out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
         printf(" %lf",param[i][j][k]);                       1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
         fprintf(ficparo," %lf",param[i][j][k]);          savm=oldm;
       }          oldm=newm;
       fscanf(ficpar,"\n");        } /* end mult */
       printf("\n");        
       fprintf(ficparo,"\n");        s1=s[mw[mi][i]][i];
     }        s2=s[mw[mi+1][i]][i];
          bbh=(double)bh[mi][i]/(double)stepm; 
   npar= (nlstate+ndeath-1)*nlstate*ncovmodel;        /* bias is positive if real duration
   p=param[1][1];         * is higher than the multiple of stepm and negative otherwise.
           */
   /* Reads comments: lines beginning with '#' */        if( s2 > nlstate && (mle <5) ){  /* Jackson */
   while((c=getc(ficpar))=='#' && c!= EOF){          lli=log(out[s1][s2] - savm[s1][s2]);
     ungetc(c,ficpar);        } else if  (s2==-2) {
     fgets(line, MAXLINE, ficpar);          for (j=1,survp=0. ; j<=nlstate; j++) 
     puts(line);            survp += (1.+bbh)*out[s1][j]- bbh*savm[s1][j];
     fputs(line,ficparo);          lli= log(survp);
   }        }else if (mle==1){
   ungetc(c,ficpar);          lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
         } else if(mle==2){
   delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
   delti=vector(1,npar); /* Scale of each paramater (output from hesscov) */        } else if(mle==3){  /* exponential inter-extrapolation */
   for(i=1; i <=nlstate; i++){          lli= (savm[s1][s2]>(double)1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
     for(j=1; j <=nlstate+ndeath-1; j++){        } else if (mle==4){  /* mle=4 no inter-extrapolation */
       fscanf(ficpar,"%1d%1d",&i1,&j1);          lli=log(out[s1][s2]); /* Original formula */
       printf("%1d%1d",i,j);        } else{  /* mle=0 back to 1 */
       fprintf(ficparo,"%1d%1d",i1,j1);          lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
       for(k=1; k<=ncovmodel;k++){          /*lli=log(out[s1][s2]); */ /* Original formula */
         fscanf(ficpar,"%le",&delti3[i][j][k]);        } /* End of if */
         printf(" %le",delti3[i][j][k]);        ipmx +=1;
         fprintf(ficparo," %le",delti3[i][j][k]);        sw += weight[i];
       }        ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       fscanf(ficpar,"\n");        /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
       printf("\n");        if(globpr){
       fprintf(ficparo,"\n");          fprintf(ficresilk,"%9d %6d %2d %2d %1d %1d %3d %11.6f %8.4f\
     }   %11.6f %11.6f %11.6f ", \
   }                  num[i],i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],
   delti=delti3[1][1];                  2*weight[i]*lli,out[s1][s2],savm[s1][s2]);
            for(k=1,llt=0.,l=0.; k<=nlstate; k++){
   /* Reads comments: lines beginning with '#' */            llt +=ll[k]*gipmx/gsw;
   while((c=getc(ficpar))=='#' && c!= EOF){            fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw);
     ungetc(c,ficpar);          }
     fgets(line, MAXLINE, ficpar);          fprintf(ficresilk," %10.6f\n", -llt);
     puts(line);        }
     fputs(line,ficparo);      } /* end of wave */
   }    } /* end of individual */
   ungetc(c,ficpar);    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
      /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
   matcov=matrix(1,npar,1,npar);    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
   for(i=1; i <=npar; i++){    if(globpr==0){ /* First time we count the contributions and weights */
     fscanf(ficpar,"%s",&str);      gipmx=ipmx;
     printf("%s",str);      gsw=sw;
     fprintf(ficparo,"%s",str);    }
     for(j=1; j <=i; j++){    return -l;
       fscanf(ficpar," %le",&matcov[i][j]);  }
       printf(" %.5le",matcov[i][j]);  
       fprintf(ficparo," %.5le",matcov[i][j]);  
     }  /*************** function likelione ***********/
     fscanf(ficpar,"\n");  void likelione(FILE *ficres,double p[], int npar, int nlstate, int *globpri, long *ipmx, double *sw, double *fretone, double (*funcone)(double []))
     printf("\n");  {
     fprintf(ficparo,"\n");    /* This routine should help understanding what is done with 
   }       the selection of individuals/waves and
   for(i=1; i <=npar; i++)       to check the exact contribution to the likelihood.
     for(j=i+1;j<=npar;j++)       Plotting could be done.
       matcov[i][j]=matcov[j][i];     */
        int k;
   printf("\n");  
     if(*globpri !=0){ /* Just counts and sums, no printings */
       strcpy(fileresilk,"ilk"); 
     /*-------- data file ----------*/      strcat(fileresilk,fileres);
     if((ficres =fopen(fileres,"w"))==NULL) {      if((ficresilk=fopen(fileresilk,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileres);goto end;        printf("Problem with resultfile: %s\n", fileresilk);
     }        fprintf(ficlog,"Problem with resultfile: %s\n", fileresilk);
     fprintf(ficres,"#%s\n",version);      }
          fprintf(ficresilk, "#individual(line's_record) s1 s2 wave# effective_wave# number_of_matrices_product pij weight -2ln(pij)*weight 0pij_x 0pij_(x-stepm) cumulating_loglikeli_by_health_state(reweighted=-2ll*weightXnumber_of_contribs/sum_of_weights) and_total\n");
     if((fic=fopen(datafile,"r"))==NULL)    {      fprintf(ficresilk, "#num_i i s1 s2 mi mw dh likeli weight 2wlli out sav ");
       printf("Problem with datafile: %s\n", datafile);goto end;      /*  i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],2*weight[i]*lli,out[s1][s2],savm[s1][s2]); */
     }      for(k=1; k<=nlstate; k++) 
         fprintf(ficresilk," -2*gipw/gsw*weight*ll[%d]++",k);
     n= lastobs;      fprintf(ficresilk," -2*gipw/gsw*weight*ll(total)\n");
     severity = vector(1,maxwav);    }
     outcome=imatrix(1,maxwav+1,1,n);  
     num=ivector(1,n);    *fretone=(*funcone)(p);
     moisnais=vector(1,n);    if(*globpri !=0){
     annais=vector(1,n);      fclose(ficresilk);
     moisdc=vector(1,n);      fprintf(fichtm,"\n<br>File of contributions to the likelihood: <a href=\"%s\">%s</a><br>\n",subdirf(fileresilk),subdirf(fileresilk));
     andc=vector(1,n);      fflush(fichtm); 
     agedc=vector(1,n);    } 
     cod=ivector(1,n);    return;
     weight=vector(1,n);  }
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */  
     mint=matrix(1,maxwav,1,n);  
     anint=matrix(1,maxwav,1,n);  /*********** Maximum Likelihood Estimation ***************/
     s=imatrix(1,maxwav+1,1,n);  
     adl=imatrix(1,maxwav+1,1,n);      void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))
     tab=ivector(1,NCOVMAX);  {
     ncodemax=ivector(1,8);    int i,j, iter;
     double **xi;
     i=1;    double fret;
     while (fgets(line, MAXLINE, fic) != NULL)    {    double fretone; /* Only one call to likelihood */
       if ((i >= firstobs) && (i <=lastobs)) {    /*  char filerespow[FILENAMELENGTH];*/
            xi=matrix(1,npar,1,npar);
         for (j=maxwav;j>=1;j--){    for (i=1;i<=npar;i++)
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb);      for (j=1;j<=npar;j++)
           strcpy(line,stra);        xi[i][j]=(i==j ? 1.0 : 0.0);
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);    printf("Powell\n");  fprintf(ficlog,"Powell\n");
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);    strcpy(filerespow,"pow"); 
         }    strcat(filerespow,fileres);
            if((ficrespow=fopen(filerespow,"w"))==NULL) {
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);      printf("Problem with resultfile: %s\n", filerespow);
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);      fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
     }
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);    fprintf(ficrespow,"# Powell\n# iter -2*LL");
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);    for (i=1;i<=nlstate;i++)
       for(j=1;j<=nlstate+ndeath;j++)
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);        if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
         for (j=ncov;j>=1;j--){    fprintf(ficrespow,"\n");
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);  
         }    powell(p,xi,npar,ftol,&iter,&fret,func);
         num[i]=atol(stra);  
     free_matrix(xi,1,npar,1,npar);
         /*printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));*/    fclose(ficrespow);
     printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));
         i=i+1;    fprintf(ficlog,"\n#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
       }    fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
     }  
   }
     /*scanf("%d",i);*/  
   imx=i-1; /* Number of individuals */  /**** Computes Hessian and covariance matrix ***/
   void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))
   /* Calculation of the number of parameter from char model*/  {
   Tvar=ivector(1,15);    double  **a,**y,*x,pd;
   Tprod=ivector(1,15);    double **hess;
   Tvaraff=ivector(1,15);    int i, j,jk;
   Tvard=imatrix(1,15,1,2);    int *indx;
   Tage=ivector(1,15);        
        double hessii(double p[], double delta, int theta, double delti[],double (*func)(double []),int npar);
   if (strlen(model) >1){    double hessij(double p[], double delti[], int i, int j,double (*func)(double []),int npar);
     j=0, j1=0, k1=1, k2=1;    void lubksb(double **a, int npar, int *indx, double b[]) ;
     j=nbocc(model,'+');    void ludcmp(double **a, int npar, int *indx, double *d) ;
     j1=nbocc(model,'*');    double gompertz(double p[]);
     cptcovn=j+1;    hess=matrix(1,npar,1,npar);
     cptcovprod=j1;  
        printf("\nCalculation of the hessian matrix. Wait...\n");
     strcpy(modelsav,model);    fprintf(ficlog,"\nCalculation of the hessian matrix. Wait...\n");
    if (j==0) {    for (i=1;i<=npar;i++){
       if (j1==0){      printf("%d",i);fflush(stdout);
         cutv(stra,strb,modelsav,'V');      fprintf(ficlog,"%d",i);fflush(ficlog);
         Tvar[1]=atoi(strb);     
       }       hess[i][i]=hessii(p,ftolhess,i,delti,func,npar);
       else if (j1==1) {      
         cutv(stra,strb,modelsav,'*');      /*  printf(" %f ",p[i]);
         Tage[1]=1; cptcovage++;          printf(" %lf %lf %lf",hess[i][i],ftolhess,delti[i]);*/
         if (strcmp(stra,"age")==0) {    }
           cptcovprod--;    
           cutv(strd,strc,strb,'V');    for (i=1;i<=npar;i++) {
           Tvar[1]=atoi(strc);      for (j=1;j<=npar;j++)  {
         }        if (j>i) { 
         else if (strcmp(strb,"age")==0) {          printf(".%d%d",i,j);fflush(stdout);
           cptcovprod--;          fprintf(ficlog,".%d%d",i,j);fflush(ficlog);
           cutv(strd,strc,stra,'V');          hess[i][j]=hessij(p,delti,i,j,func,npar);
           Tvar[1]=atoi(strc);          
         }          hess[j][i]=hess[i][j];    
         else {          /*printf(" %lf ",hess[i][j]);*/
           cutv(strd,strc,strb,'V');        }
           cutv(stre,strd,stra,'V');      }
           Tvar[1]=ncov+1;    }
           for (k=1; k<=lastobs;k++)    printf("\n");
               covar[ncov+1][k]=covar[atoi(strc)][k]*covar[atoi(strd)][k];    fprintf(ficlog,"\n");
         }  
         /*printf("%s %s %s\n", stra,strb,modelsav);    printf("\nInverting the hessian to get the covariance matrix. Wait...\n");
 printf("%d ",Tvar[1]);    fprintf(ficlog,"\nInverting the hessian to get the covariance matrix. Wait...\n");
 scanf("%d",i);*/    
       }    a=matrix(1,npar,1,npar);
     }    y=matrix(1,npar,1,npar);
    else {    x=vector(1,npar);
       for(i=j; i>=1;i--){    indx=ivector(1,npar);
         cutv(stra,strb,modelsav,'+');    for (i=1;i<=npar;i++)
         /*printf("%s %s %s\n", stra,strb,modelsav);      for (j=1;j<=npar;j++) a[i][j]=hess[i][j];
           scanf("%d",i);*/    ludcmp(a,npar,indx,&pd);
         if (strchr(strb,'*')) {  
           cutv(strd,strc,strb,'*');    for (j=1;j<=npar;j++) {
           if (strcmp(strc,"age")==0) {      for (i=1;i<=npar;i++) x[i]=0;
             cptcovprod--;      x[j]=1;
             cutv(strb,stre,strd,'V');      lubksb(a,npar,indx,x);
             Tvar[i+1]=atoi(stre);      for (i=1;i<=npar;i++){ 
             cptcovage++;        matcov[i][j]=x[i];
             Tage[cptcovage]=i+1;      }
             printf("stre=%s ", stre);    }
           }  
           else if (strcmp(strd,"age")==0) {    printf("\n#Hessian matrix#\n");
             cptcovprod--;    fprintf(ficlog,"\n#Hessian matrix#\n");
             cutv(strb,stre,strc,'V');    for (i=1;i<=npar;i++) { 
             Tvar[i+1]=atoi(stre);      for (j=1;j<=npar;j++) { 
             cptcovage++;        printf("%.3e ",hess[i][j]);
             Tage[cptcovage]=i+1;        fprintf(ficlog,"%.3e ",hess[i][j]);
           }      }
           else {      printf("\n");
             cutv(strb,stre,strc,'V');      fprintf(ficlog,"\n");
             Tvar[i+1]=ncov+k1;    }
             cutv(strb,strc,strd,'V');  
             Tprod[k1]=i+1;    /* Recompute Inverse */
             Tvard[k1][1]=atoi(strc);    for (i=1;i<=npar;i++)
             Tvard[k1][2]=atoi(stre);      for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];
             Tvar[cptcovn+k2]=Tvard[k1][1];    ludcmp(a,npar,indx,&pd);
             Tvar[cptcovn+k2+1]=Tvard[k1][2];  
             for (k=1; k<=lastobs;k++)    /*  printf("\n#Hessian matrix recomputed#\n");
               covar[ncov+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];  
             k1++;    for (j=1;j<=npar;j++) {
             k2=k2+2;      for (i=1;i<=npar;i++) x[i]=0;
           }      x[j]=1;
         }      lubksb(a,npar,indx,x);
         else {      for (i=1;i<=npar;i++){ 
           cutv(strd,strc,strb,'V');        y[i][j]=x[i];
           /* printf("%s %s %s", strd,strc,strb);*/        printf("%.3e ",y[i][j]);
           Tvar[i+1]=atoi(strc);        fprintf(ficlog,"%.3e ",y[i][j]);
         }      }
         strcpy(modelsav,stra);        printf("\n");
       }      fprintf(ficlog,"\n");
       cutv(strd,strc,stra,'V');    }
       Tvar[1]=atoi(strc);    */
     }  
   }    free_matrix(a,1,npar,1,npar);
   /* for (i=1; i<=5; i++)    free_matrix(y,1,npar,1,npar);
      printf("i=%d %d ",i,Tvar[i]);*/    free_vector(x,1,npar);
   /* printf("tvar=%d %d cptcovage=%d %d",Tvar[1],Tvar[2],cptcovage,Tage[1]);*/    free_ivector(indx,1,npar);
  /*printf("cptcovprod=%d ", cptcovprod);*/    free_matrix(hess,1,npar,1,npar);
   /*  scanf("%d ",i);*/  
     fclose(fic);  
   }
     /*  if(mle==1){*/  
     if (weightopt != 1) { /* Maximisation without weights*/  /*************** hessian matrix ****************/
       for(i=1;i<=n;i++) weight[i]=1.0;  double hessii(double x[], double delta, int theta, double delti[], double (*func)(double []), int npar)
     }  {
     /*-calculation of age at interview from date of interview and age at death -*/    int i;
     agev=matrix(1,maxwav,1,imx);    int l=1, lmax=20;
        double k1,k2;
     for (i=1; i<=imx; i++)  {    double p2[MAXPARM+1]; /* identical to x */
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);    double res;
       for(m=1; (m<= maxwav); m++){    double delt=0.0001, delts, nkhi=10.,nkhif=1., khi=1.e-4;
         if(s[m][i] >0){    double fx;
           if (s[m][i] == nlstate+1) {    int k=0,kmax=10;
             if(agedc[i]>0)    double l1;
               if(moisdc[i]!=99 && andc[i]!=9999)  
               agev[m][i]=agedc[i];    fx=func(x);
             else{    for (i=1;i<=npar;i++) p2[i]=x[i];
               printf("Warning negative age at death: %d line:%d\n",num[i],i);    for(l=0 ; l <=lmax; l++){
               agev[m][i]=-1;      l1=pow(10,l);
             }      delts=delt;
           }      for(k=1 ; k <kmax; k=k+1){
           else if(s[m][i] !=9){ /* Should no more exist */        delt = delta*(l1*k);
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);        p2[theta]=x[theta] +delt;
             if(mint[m][i]==99 || anint[m][i]==9999)        k1=func(p2)-fx;
               agev[m][i]=1;        p2[theta]=x[theta]-delt;
             else if(agev[m][i] <agemin){        k2=func(p2)-fx;
               agemin=agev[m][i];        /*res= (k1-2.0*fx+k2)/delt/delt; */
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/        res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */
             }        
             else if(agev[m][i] >agemax){  #ifdef DEBUGHESS
               agemax=agev[m][i];        printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
              /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/        fprintf(ficlog,"%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
             }  #endif
             /*agev[m][i]=anint[m][i]-annais[i];*/        /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */
             /*   agev[m][i] = age[i]+2*m;*/        if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){
           }          k=kmax;
           else { /* =9 */        }
             agev[m][i]=1;        else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */
             s[m][i]=-1;          k=kmax; l=lmax*10.;
           }        }
         }        else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){ 
         else /*= 0 Unknown */          delts=delt;
           agev[m][i]=1;        }
       }      }
        }
     }    delti[theta]=delts;
     for (i=1; i<=imx; i++)  {    return res; 
       for(m=1; (m<= maxwav); m++){    
         if (s[m][i] > (nlstate+ndeath)) {  }
           printf("Error: Wrong value in nlstate or ndeath\n");    
           goto end;  double hessij( double x[], double delti[], int thetai,int thetaj,double (*func)(double []),int npar)
         }  {
       }    int i;
     }    int l=1, l1, lmax=20;
     double k1,k2,k3,k4,res,fx;
 printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);    double p2[MAXPARM+1];
     int k;
     free_vector(severity,1,maxwav);  
     free_imatrix(outcome,1,maxwav+1,1,n);    fx=func(x);
     free_vector(moisnais,1,n);    for (k=1; k<=2; k++) {
     free_vector(annais,1,n);      for (i=1;i<=npar;i++) p2[i]=x[i];
     free_matrix(mint,1,maxwav,1,n);      p2[thetai]=x[thetai]+delti[thetai]/k;
     free_matrix(anint,1,maxwav,1,n);      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
     free_vector(moisdc,1,n);      k1=func(p2)-fx;
     free_vector(andc,1,n);    
       p2[thetai]=x[thetai]+delti[thetai]/k;
          p2[thetaj]=x[thetaj]-delti[thetaj]/k;
     wav=ivector(1,imx);      k2=func(p2)-fx;
     dh=imatrix(1,lastpass-firstpass+1,1,imx);    
     mw=imatrix(1,lastpass-firstpass+1,1,imx);      p2[thetai]=x[thetai]-delti[thetai]/k;
          p2[thetaj]=x[thetaj]+delti[thetaj]/k;
     /* Concatenates waves */      k3=func(p2)-fx;
       concatwav(wav, dh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);    
       p2[thetai]=x[thetai]-delti[thetai]/k;
       p2[thetaj]=x[thetaj]-delti[thetaj]/k;
       Tcode=ivector(1,100);      k4=func(p2)-fx;
       nbcode=imatrix(1,nvar,1,8);      res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */
       ncodemax[1]=1;  #ifdef DEBUG
       if (cptcovn > 0) tricode(Tvar,nbcode,imx);      printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
            fprintf(ficlog,"%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
    codtab=imatrix(1,100,1,10);  #endif
    h=0;    }
    m=pow(2,cptcoveff);    return res;
    }
    for(k=1;k<=cptcoveff; k++){  
      for(i=1; i <=(m/pow(2,k));i++){  /************** Inverse of matrix **************/
        for(j=1; j <= ncodemax[k]; j++){  void ludcmp(double **a, int n, int *indx, double *d) 
          for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){  { 
            h++;    int i,imax,j,k; 
            if (h>m) h=1;codtab[h][k]=j;    double big,dum,sum,temp; 
          }    double *vv; 
        }   
      }    vv=vector(1,n); 
    }    *d=1.0; 
     for (i=1;i<=n;i++) { 
       big=0.0; 
    /*for(i=1; i <=m ;i++){      for (j=1;j<=n;j++) 
      for(k=1; k <=cptcovn; k++){        if ((temp=fabs(a[i][j])) > big) big=temp; 
        printf("i=%d k=%d %d %d",i,k,codtab[i][k], cptcoveff);      if (big == 0.0) nrerror("Singular matrix in routine ludcmp"); 
      }      vv[i]=1.0/big; 
      printf("\n");    } 
    }    for (j=1;j<=n;j++) { 
    scanf("%d",i);*/      for (i=1;i<j;i++) { 
            sum=a[i][j]; 
    /* Calculates basic frequencies. Computes observed prevalence at single age        for (k=1;k<i;k++) sum -= a[i][k]*a[k][j]; 
        and prints on file fileres'p'. */        a[i][j]=sum; 
   freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax);      } 
       big=0.0; 
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */      for (i=j;i<=n;i++) { 
     oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */        sum=a[i][j]; 
     newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */        for (k=1;k<j;k++) 
     savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */          sum -= a[i][k]*a[k][j]; 
     oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */        a[i][j]=sum; 
            if ( (dum=vv[i]*fabs(sum)) >= big) { 
     /* For Powell, parameters are in a vector p[] starting at p[1]          big=dum; 
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */          imax=i; 
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */        } 
       } 
     if(mle==1){      if (j != imax) { 
     mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);        for (k=1;k<=n;k++) { 
     }          dum=a[imax][k]; 
              a[imax][k]=a[j][k]; 
     /*--------- results files --------------*/          a[j][k]=dum; 
     fprintf(ficres,"\ntitle=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate, ndeath, maxwav, mle,weightopt,model);        } 
            *d = -(*d); 
    jk=1;        vv[imax]=vv[j]; 
    fprintf(ficres,"# Parameters\n");      } 
    printf("# Parameters\n");      indx[j]=imax; 
    for(i=1,jk=1; i <=nlstate; i++){      if (a[j][j] == 0.0) a[j][j]=TINY; 
      for(k=1; k <=(nlstate+ndeath); k++){      if (j != n) { 
        if (k != i)        dum=1.0/(a[j][j]); 
          {        for (i=j+1;i<=n;i++) a[i][j] *= dum; 
            printf("%d%d ",i,k);      } 
            fprintf(ficres,"%1d%1d ",i,k);    } 
            for(j=1; j <=ncovmodel; j++){    free_vector(vv,1,n);  /* Doesn't work */
              printf("%f ",p[jk]);  ;
              fprintf(ficres,"%f ",p[jk]);  } 
              jk++;  
            }  void lubksb(double **a, int n, int *indx, double b[]) 
            printf("\n");  { 
            fprintf(ficres,"\n");    int i,ii=0,ip,j; 
          }    double sum; 
      }   
    }    for (i=1;i<=n;i++) { 
  if(mle==1){      ip=indx[i]; 
     /* Computing hessian and covariance matrix */      sum=b[ip]; 
     ftolhess=ftol; /* Usually correct */      b[ip]=b[i]; 
     hesscov(matcov, p, npar, delti, ftolhess, func);      if (ii) 
  }        for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j]; 
     fprintf(ficres,"# Scales\n");      else if (sum) ii=i; 
     printf("# Scales\n");      b[i]=sum; 
      for(i=1,jk=1; i <=nlstate; i++){    } 
       for(j=1; j <=nlstate+ndeath; j++){    for (i=n;i>=1;i--) { 
         if (j!=i) {      sum=b[i]; 
           fprintf(ficres,"%1d%1d",i,j);      for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j]; 
           printf("%1d%1d",i,j);      b[i]=sum/a[i][i]; 
           for(k=1; k<=ncovmodel;k++){    } 
             printf(" %.5e",delti[jk]);  } 
             fprintf(ficres," %.5e",delti[jk]);  
             jk++;  void pstamp(FILE *fichier)
           }  {
           printf("\n");    fprintf(fichier,"# %s.%s\n#%s\n#%s\n# %s", optionfilefiname,optionfilext,version,fullversion,strstart);
           fprintf(ficres,"\n");  }
         }  
       }  /************ Frequencies ********************/
       }  void  freqsummary(char fileres[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, int *Tvaraff, int **nbcode, int *ncodemax,double **mint,double **anint, char strstart[])
      {  /* Some frequencies */
     k=1;    
     fprintf(ficres,"# Covariance\n");    int i, m, jk, k1,i1, j1, bool, z1,j;
     printf("# Covariance\n");    int first;
     for(i=1;i<=npar;i++){    double ***freq; /* Frequencies */
       /*  if (k>nlstate) k=1;    double *pp, **prop;
       i1=(i-1)/(ncovmodel*nlstate)+1;    double pos,posprop, k2, dateintsum=0,k2cpt=0;
       fprintf(ficres,"%s%d%d",alph[k],i1,tab[i]);    char fileresp[FILENAMELENGTH];
       printf("%s%d%d",alph[k],i1,tab[i]);*/    
       fprintf(ficres,"%3d",i);    pp=vector(1,nlstate);
       printf("%3d",i);    prop=matrix(1,nlstate,iagemin,iagemax+3);
       for(j=1; j<=i;j++){    strcpy(fileresp,"p");
         fprintf(ficres," %.5e",matcov[i][j]);    strcat(fileresp,fileres);
         printf(" %.5e",matcov[i][j]);    if((ficresp=fopen(fileresp,"w"))==NULL) {
       }      printf("Problem with prevalence resultfile: %s\n", fileresp);
       fprintf(ficres,"\n");      fprintf(ficlog,"Problem with prevalence resultfile: %s\n", fileresp);
       printf("\n");      exit(0);
       k++;    }
     }    freq= ma3x(-5,nlstate+ndeath,-5,nlstate+ndeath,iagemin,iagemax+3);
        j1=0;
     while((c=getc(ficpar))=='#' && c!= EOF){    
       ungetc(c,ficpar);    j=cptcoveff;
       fgets(line, MAXLINE, ficpar);    if (cptcovn<1) {j=1;ncodemax[1]=1;}
       puts(line);  
       fputs(line,ficparo);    first=1;
     }  
     ungetc(c,ficpar);    for(k1=1; k1<=j;k1++){
        for(i1=1; i1<=ncodemax[k1];i1++){
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);        j1++;
            /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);
     if (fage <= 2) {          scanf("%d", i);*/
       bage = agemin;        for (i=-5; i<=nlstate+ndeath; i++)  
       fage = agemax;          for (jk=-5; jk<=nlstate+ndeath; jk++)  
     }            for(m=iagemin; m <= iagemax+3; m++)
               freq[i][jk][m]=0;
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");  
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);      for (i=1; i<=nlstate; i++)  
         for(m=iagemin; m <= iagemax+3; m++)
              prop[i][m]=0;
 /*------------ gnuplot -------------*/        
 chdir(pathcd);        dateintsum=0;
   if((ficgp=fopen("graph.plt","w"))==NULL) {        k2cpt=0;
     printf("Problem with file graph.gp");goto end;        for (i=1; i<=imx; i++) {
   }          bool=1;
 #ifdef windows          if  (cptcovn>0) {
   fprintf(ficgp,"cd \"%s\" \n",pathc);            for (z1=1; z1<=cptcoveff; z1++) 
 #endif              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
 m=pow(2,cptcoveff);                bool=0;
            }
  /* 1eme*/          if (bool==1){
   for (cpt=1; cpt<= nlstate ; cpt ++) {            for(m=firstpass; m<=lastpass; m++){
    for (k1=1; k1<= m ; k1 ++) {              k2=anint[m][i]+(mint[m][i]/12.);
               /*if ((k2>=dateprev1) && (k2<=dateprev2)) {*/
 #ifdef windows                if(agev[m][i]==0) agev[m][i]=iagemax+1;
     fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"vpl%s\" every :::%d::%d u 1:2 \"\%%lf",agemin,fage,fileres,k1-1,k1-1);                if(agev[m][i]==1) agev[m][i]=iagemax+2;
 #endif                if (s[m][i]>0 && s[m][i]<=nlstate) prop[s[m][i]][(int)agev[m][i]] += weight[i];
 #ifdef unix                if (m<lastpass) {
 fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nplot [%.f:%.f] \"vpl%s\" u 1:2 \"\%%lf",agemin,fage,fileres);                  freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];
 #endif                  freq[s[m][i]][s[m+1][i]][iagemax+3] += weight[i];
                 }
 for (i=1; i<= nlstate ; i ++) {                
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");                if ((agev[m][i]>1) && (agev[m][i]< (iagemax+3))) {
   else fprintf(ficgp," \%%*lf (\%%*lf)");                  dateintsum=dateintsum+k2;
 }                  k2cpt++;
     fprintf(ficgp,"\" t\"Stationary prevalence\" w l 0,\"vpl%s\" every :::%d::%d u 1:($2+2*$3) \"\%%lf",fileres,k1-1,k1-1);                }
     for (i=1; i<= nlstate ; i ++) {                /*}*/
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");            }
   else fprintf(ficgp," \%%*lf (\%%*lf)");          }
 }        }
   fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"vpl%s\" every :::%d::%d u 1:($2-2*$3) \"\%%lf",fileres,k1-1,k1-1);         
      for (i=1; i<= nlstate ; i ++) {        /*      fprintf(ficresp, "#Count between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");        pstamp(ficresp);
   else fprintf(ficgp," \%%*lf (\%%*lf)");        if  (cptcovn>0) {
 }            fprintf(ficresp, "\n#********** Variable "); 
      fprintf(ficgp,"\" t\"\" w l 1,\"p%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",fileres,k1-1,k1-1,2+4*(cpt-1));          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
 #ifdef unix          fprintf(ficresp, "**********\n#");
 fprintf(ficgp,"\nset ter gif small size 400,300");        }
 #endif        for(i=1; i<=nlstate;i++) 
 fprintf(ficgp,"\nset out \"v%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);
    }        fprintf(ficresp, "\n");
   }        
   /*2 eme*/        for(i=iagemin; i <= iagemax+3; i++){
           if(i==iagemax+3){
   for (k1=1; k1<= m ; k1 ++) {            fprintf(ficlog,"Total");
     fprintf(ficgp,"set ylabel \"Years\" \nset ter gif small size 400,300\nplot [%.f:%.f] ",agemin,fage);          }else{
                if(first==1){
     for (i=1; i<= nlstate+1 ; i ++) {              first=0;
       k=2*i;              printf("See log file for details...\n");
       fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:2 \"\%%lf",fileres,k1-1,k1-1);            }
       for (j=1; j<= nlstate+1 ; j ++) {            fprintf(ficlog,"Age %d", i);
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");          }
   else fprintf(ficgp," \%%*lf (\%%*lf)");          for(jk=1; jk <=nlstate ; jk++){
 }              for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)
       if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");              pp[jk] += freq[jk][m][i]; 
       else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);          }
     fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",fileres,k1-1,k1-1);          for(jk=1; jk <=nlstate ; jk++){
       for (j=1; j<= nlstate+1 ; j ++) {            for(m=-1, pos=0; m <=0 ; m++)
         if (j==i) fprintf(ficgp," \%%lf (\%%lf)");              pos += freq[jk][m][i];
         else fprintf(ficgp," \%%*lf (\%%*lf)");            if(pp[jk]>=1.e-10){
 }                if(first==1){
       fprintf(ficgp,"\" t\"\" w l 0,");                printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
      fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",fileres,k1-1,k1-1);              }
       for (j=1; j<= nlstate+1 ; j ++) {              fprintf(ficlog," %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");            }else{
   else fprintf(ficgp," \%%*lf (\%%*lf)");              if(first==1)
 }                  printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
       if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");              fprintf(ficlog," %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
       else fprintf(ficgp,"\" t\"\" w l 0,");            }
     }          }
     fprintf(ficgp,"\nset out \"e%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),k1);  
   }          for(jk=1; jk <=nlstate ; jk++){
              for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)
   /*3eme*/              pp[jk] += freq[jk][m][i];
           }       
   for (k1=1; k1<= m ; k1 ++) {          for(jk=1,pos=0,posprop=0; jk <=nlstate ; jk++){
     for (cpt=1; cpt<= nlstate ; cpt ++) {            pos += pp[jk];
       k=2+nlstate*(cpt-1);            posprop += prop[jk][i];
       fprintf(ficgp,"set ter gif small size 400,300\nplot [%.f:%.f] \"e%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",agemin,fage,fileres,k1-1,k1-1,k,cpt);          }
       for (i=1; i< nlstate ; i ++) {          for(jk=1; jk <=nlstate ; jk++){
         fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",fileres,k1-1,k1-1,k+i,cpt,i+1);            if(pos>=1.e-5){
       }              if(first==1)
       fprintf(ficgp,"\nset out \"exp%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);                printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
     }              fprintf(ficlog," %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
   }            }else{
                if(first==1)
   /* CV preval stat */                printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
   for (k1=1; k1<= m ; k1 ++) {              fprintf(ficlog," %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     for (cpt=1; cpt<nlstate ; cpt ++) {            }
       k=3;            if( i <= iagemax){
       fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",agemin,agemax,fileres,k1,k+cpt+1,k+1);              if(pos>=1.e-5){
       for (i=1; i< nlstate ; i ++)                fprintf(ficresp," %d %.5f %.0f %.0f",i,prop[jk][i]/posprop, prop[jk][i],posprop);
         fprintf(ficgp,"+$%d",k+i+1);                /*probs[i][jk][j1]= pp[jk]/pos;*/
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);                /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/
                    }
       l=3+(nlstate+ndeath)*cpt;              else
       fprintf(ficgp,",\"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",fileres,k1,l+cpt+1,l+1);                fprintf(ficresp," %d NaNq %.0f %.0f",i,prop[jk][i],posprop);
       for (i=1; i< nlstate ; i ++) {            }
         l=3+(nlstate+ndeath)*cpt;          }
         fprintf(ficgp,"+$%d",l+i+1);          
       }          for(jk=-1; jk <=nlstate+ndeath; jk++)
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);              for(m=-1; m <=nlstate+ndeath; m++)
       fprintf(ficgp,"set out \"p%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);              if(freq[jk][m][i] !=0 ) {
     }              if(first==1)
   }                printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);
                 fprintf(ficlog," %d%d=%.0f",jk,m,freq[jk][m][i]);
   /* proba elementaires */              }
    for(i=1,jk=1; i <=nlstate; i++){          if(i <= iagemax)
     for(k=1; k <=(nlstate+ndeath); k++){            fprintf(ficresp,"\n");
       if (k != i) {          if(first==1)
         for(j=1; j <=ncovmodel; j++){            printf("Others in log...\n");
           /*fprintf(ficgp,"%s%1d%1d=%f ",alph[j],i,k,p[jk]);*/          fprintf(ficlog,"\n");
           /*fprintf(ficgp,"%s",alph[1]);*/        }
           fprintf(ficgp,"p%d=%f ",jk,p[jk]);      }
           jk++;    }
           fprintf(ficgp,"\n");    dateintmean=dateintsum/k2cpt; 
         }   
       }    fclose(ficresp);
     }    free_ma3x(freq,-5,nlstate+ndeath,-5,nlstate+ndeath, iagemin, iagemax+3);
     }    free_vector(pp,1,nlstate);
     free_matrix(prop,1,nlstate,iagemin, iagemax+3);
   for(jk=1; jk <=m; jk++) {    /* End of Freq */
   fprintf(ficgp,"\nset ter gif small size 400,300\nset log y\nplot  [%.f:%.f] ",agemin,agemax);  }
    i=1;  
    for(k2=1; k2<=nlstate; k2++) {  /************ Prevalence ********************/
      k3=i;  void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass)
      for(k=1; k<=(nlstate+ndeath); k++) {  {  
        if (k != k2){    /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people
         fprintf(ficgp," exp(p%d+p%d*x",i,i+1);       in each health status at the date of interview (if between dateprev1 and dateprev2).
 ij=1;       We still use firstpass and lastpass as another selection.
         for(j=3; j <=ncovmodel; j++) {    */
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {   
             fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);    int i, m, jk, k1, i1, j1, bool, z1,j;
             ij++;    double ***freq; /* Frequencies */
           }    double *pp, **prop;
           else    double pos,posprop; 
           fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);    double  y2; /* in fractional years */
         }    int iagemin, iagemax;
           fprintf(ficgp,")/(1");  
            iagemin= (int) agemin;
         for(k1=1; k1 <=nlstate; k1++){      iagemax= (int) agemax;
           fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);    /*pp=vector(1,nlstate);*/
 ij=1;    prop=matrix(1,nlstate,iagemin,iagemax+3); 
           for(j=3; j <=ncovmodel; j++){    /*  freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);*/
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {    j1=0;
             fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);    
             ij++;    j=cptcoveff;
           }    if (cptcovn<1) {j=1;ncodemax[1]=1;}
           else    
             fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);    for(k1=1; k1<=j;k1++){
           }      for(i1=1; i1<=ncodemax[k1];i1++){
           fprintf(ficgp,")");        j1++;
         }        
         fprintf(ficgp,") t \"p%d%d\" ", k2,k);        for (i=1; i<=nlstate; i++)  
         if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");          for(m=iagemin; m <= iagemax+3; m++)
         i=i+ncovmodel;            prop[i][m]=0.0;
        }       
      }        for (i=1; i<=imx; i++) { /* Each individual */
    }          bool=1;
    fprintf(ficgp,"\nset out \"pe%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),jk);          if  (cptcovn>0) {
   }            for (z1=1; z1<=cptcoveff; z1++) 
                  if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
   fclose(ficgp);                bool=0;
              } 
 chdir(path);          if (bool==1) { 
     free_matrix(agev,1,maxwav,1,imx);            for(m=firstpass; m<=lastpass; m++){/* Other selection (we can limit to certain interviews*/
     free_ivector(wav,1,imx);              y2=anint[m][i]+(mint[m][i]/12.); /* Fractional date in year */
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);              if ((y2>=dateprev1) && (y2<=dateprev2)) { /* Here is the main selection (fractional years) */
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);                if(agev[m][i]==0) agev[m][i]=iagemax+1;
                    if(agev[m][i]==1) agev[m][i]=iagemax+2;
     free_imatrix(s,1,maxwav+1,1,n);                if((int)agev[m][i] <iagemin || (int)agev[m][i] >iagemax+3) printf("Error on individual =%d agev[m][i]=%f m=%d\n",i, agev[m][i],m); 
                    if (s[m][i]>0 && s[m][i]<=nlstate) { 
                      /*if(i>4620) printf(" i=%d m=%d s[m][i]=%d (int)agev[m][i]=%d weight[i]=%f prop=%f\n",i,m,s[m][i],(int)agev[m][m],weight[i],prop[s[m][i]][(int)agev[m][i]]);*/
     free_ivector(num,1,n);                  prop[s[m][i]][(int)agev[m][i]] += weight[i];
     free_vector(agedc,1,n);                  prop[s[m][i]][iagemax+3] += weight[i]; 
     free_vector(weight,1,n);                } 
     /*free_matrix(covar,1,NCOVMAX,1,n);*/              }
     fclose(ficparo);            } /* end selection of waves */
     fclose(ficres);          }
     /*  }*/        }
            for(i=iagemin; i <= iagemax+3; i++){  
    /*________fin mle=1_________*/          
              for(jk=1,posprop=0; jk <=nlstate ; jk++) { 
             posprop += prop[jk][i]; 
            } 
     /* No more information from the sample is required now */  
   /* Reads comments: lines beginning with '#' */          for(jk=1; jk <=nlstate ; jk++){     
   while((c=getc(ficpar))=='#' && c!= EOF){            if( i <=  iagemax){ 
     ungetc(c,ficpar);              if(posprop>=1.e-5){ 
     fgets(line, MAXLINE, ficpar);                probs[i][jk][j1]= prop[jk][i]/posprop;
     puts(line);              } else
     fputs(line,ficparo);                printf("Warning Observed prevalence probs[%d][%d][%d]=%lf because of lack of cases\n",jk,i,j1,probs[i][jk][j1]);
   }            } 
   ungetc(c,ficpar);          }/* end jk */ 
          }/* end i */ 
   fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);      } /* end i1 */
   printf("agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax, bage, fage);    } /* end k1 */
   fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);    
 /*--------- index.htm --------*/    /*  free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);*/
     /*free_vector(pp,1,nlstate);*/
   if((fichtm=fopen("index.htm","w"))==NULL)    {    free_matrix(prop,1,nlstate, iagemin,iagemax+3);
     printf("Problem with index.htm \n");goto end;  }  /* End of prevalence */
   }  
   /************* Waves Concatenation ***************/
  fprintf(fichtm,"<body><ul> Imach, Version 0.64a<hr> <li>Outputs files<br><br>\n  
         - Observed prevalence in each state: <a href=\"p%s\">p%s</a> <br>\n  void  concatwav(int wav[], int **dh, int **bh,  int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)
 - Estimated parameters and the covariance matrix: <a href=\"%s\">%s</a> <br>  {
         - Stationary prevalence in each state: <a href=\"pl%s\">pl%s</a> <br>    /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.
         - Transition probabilities: <a href=\"pij%s\">pij%s</a><br>       Death is a valid wave (if date is known).
         - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>       mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i
         - Life expectancies by age and initial health status: <a href=\"e%s\">e%s</a> <br>       dh[m][i] or dh[mw[mi][i]][i] is the delay between two effective waves m=mw[mi][i]
         - Variances of life expectancies by age and initial health status: <a href=\"v%s\">v%s</a><br>       and mw[mi+1][i]. dh depends on stepm.
         - Health expectancies with their variances: <a href=\"t%s\">t%s</a> <br>       */
         - Standard deviation of stationary prevalences: <a href=\"vpl%s\">vpl%s</a> <br><br>",fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres);  
     int i, mi, m;
  fprintf(fichtm," <li>Graphs</li>\n<p>");    /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;
        double sum=0., jmean=0.;*/
  m=cptcoveff;    int first;
  if (cptcovn < 1) {m=1;ncodemax[1]=1;}    int j, k=0,jk, ju, jl;
     double sum=0.;
  j1=0;    first=0;
  for(k1=1; k1<=m;k1++){    jmin=1e+5;
    for(i1=1; i1<=ncodemax[k1];i1++){    jmax=-1;
        j1++;    jmean=0.;
        if (cptcovn > 0) {    for(i=1; i<=imx; i++){
          fprintf(fichtm,"<hr>************ Results for covariates");      mi=0;
          for (cpt=1; cpt<=cptcoveff;cpt++)      m=firstpass;
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[j1][cpt]]);      while(s[m][i] <= nlstate){
          fprintf(fichtm," ************\n<hr>");        if(s[m][i]>=1 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5)
        }          mw[++mi][i]=m;
        fprintf(fichtm,"<br>- Probabilities: pe%s%d.gif<br>        if(m >=lastpass)
 <img src=\"pe%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);              break;
        for(cpt=1; cpt<nlstate;cpt++){        else
          fprintf(fichtm,"<br>- Prevalence of disability : p%s%d%d.gif<br>          m++;
 <img src=\"p%s%d%d.gif\">",strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);      }/* end while */
        }      if (s[m][i] > nlstate){
     for(cpt=1; cpt<=nlstate;cpt++) {        mi++;     /* Death is another wave */
        fprintf(fichtm,"<br>- Observed and stationary prevalence (with confident        /* if(mi==0)  never been interviewed correctly before death */
 interval) in state (%d): v%s%d%d.gif <br>           /* Only death is a correct wave */
 <img src=\"v%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);          mw[mi][i]=m;
      }      }
      for(cpt=1; cpt<=nlstate;cpt++) {  
         fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): exp%s%d%d.gif <br>      wav[i]=mi;
 <img src=\"exp%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);      if(mi==0){
      }        nbwarn++;
      fprintf(fichtm,"\n<br>- Total life expectancy by age and        if(first==0){
 health expectancies in states (1) and (2): e%s%d.gif<br>          printf("Warning! No valid information for individual %ld line=%d (skipped) and may be others, see log file\n",num[i],i);
 <img src=\"e%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);          first=1;
 fprintf(fichtm,"\n</body>");        }
    }        if(first==1){
  }          fprintf(ficlog,"Warning! No valid information for individual %ld line=%d (skipped)\n",num[i],i);
 fclose(fichtm);        }
       } /* end mi==0 */
   /*--------------- Prevalence limit --------------*/    } /* End individuals */
    
   strcpy(filerespl,"pl");    for(i=1; i<=imx; i++){
   strcat(filerespl,fileres);      for(mi=1; mi<wav[i];mi++){
   if((ficrespl=fopen(filerespl,"w"))==NULL) {        if (stepm <=0)
     printf("Problem with Prev limit resultfile: %s\n", filerespl);goto end;          dh[mi][i]=1;
   }        else{
   printf("Computing prevalence limit: result on file '%s' \n", filerespl);          if (s[mw[mi+1][i]][i] > nlstate) { /* A death */
   fprintf(ficrespl,"#Prevalence limit\n");            if (agedc[i] < 2*AGESUP) {
   fprintf(ficrespl,"#Age ");              j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12); 
   for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);              if(j==0) j=1;  /* Survives at least one month after exam */
   fprintf(ficrespl,"\n");              else if(j<0){
                  nberr++;
   prlim=matrix(1,nlstate,1,nlstate);                printf("Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */                j=1; /* Temporary Dangerous patch */
   oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */                printf("   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
   newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */                fprintf(ficlog,"Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */                fprintf(ficlog,"   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
   oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */              }
   k=0;              k=k+1;
   agebase=agemin;              if (j >= jmax){
   agelim=agemax;                jmax=j;
   ftolpl=1.e-10;                ijmax=i;
   i1=cptcoveff;              }
   if (cptcovn < 1){i1=1;}              if (j <= jmin){
                 jmin=j;
   for(cptcov=1;cptcov<=i1;cptcov++){                ijmin=i;
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){              }
         k=k+1;              sum=sum+j;
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/              /*if (j<0) printf("j=%d num=%d \n",j,i);*/
         fprintf(ficrespl,"\n#******");              /*    printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
         for(j=1;j<=cptcoveff;j++)            }
           fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);          }
         fprintf(ficrespl,"******\n");          else{
                    j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));
         for (age=agebase; age<=agelim; age++){  /*        if (j<0) printf("%d %lf %lf %d %d %d\n", i,agev[mw[mi+1][i]][i], agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]); */
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);  
           fprintf(ficrespl,"%.0f",age );            k=k+1;
           for(i=1; i<=nlstate;i++)            if (j >= jmax) {
           fprintf(ficrespl," %.5f", prlim[i][i]);              jmax=j;
           fprintf(ficrespl,"\n");              ijmax=i;
         }            }
       }            else if (j <= jmin){
     }              jmin=j;
   fclose(ficrespl);              ijmin=i;
   /*------------- h Pij x at various ages ------------*/            }
              /*        if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */
   strcpy(filerespij,"pij");  strcat(filerespij,fileres);            /*printf("%d %lf %d %d %d\n", i,agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);*/
   if((ficrespij=fopen(filerespij,"w"))==NULL) {            if(j<0){
     printf("Problem with Pij resultfile: %s\n", filerespij);goto end;              nberr++;
   }              printf("Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   printf("Computing pij: result on file '%s' \n", filerespij);              fprintf(ficlog,"Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
              }
   stepsize=(int) (stepm+YEARM-1)/YEARM;            sum=sum+j;
   if (stepm<=24) stepsize=2;          }
           jk= j/stepm;
   agelim=AGESUP;          jl= j -jk*stepm;
   hstepm=stepsize*YEARM; /* Every year of age */          ju= j -(jk+1)*stepm;
   hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */          if(mle <=1){ /* only if we use a the linear-interpoloation pseudo-likelihood */
              if(jl==0){
   k=0;              dh[mi][i]=jk;
   for(cptcov=1;cptcov<=i1;cptcov++){              bh[mi][i]=0;
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){            }else{ /* We want a negative bias in order to only have interpolation ie
       k=k+1;                    * to avoid the price of an extra matrix product in likelihood */
         fprintf(ficrespij,"\n#****** ");              dh[mi][i]=jk+1;
         for(j=1;j<=cptcoveff;j++)              bh[mi][i]=ju;
           fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);            }
         fprintf(ficrespij,"******\n");          }else{
                    if(jl <= -ju){
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */              dh[mi][i]=jk;
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */              bh[mi][i]=jl;       /* bias is positive if real duration
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */                                   * is higher than the multiple of stepm and negative otherwise.
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);                                   */
           oldm=oldms;savm=savms;            }
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);              else{
           fprintf(ficrespij,"# Age");              dh[mi][i]=jk+1;
           for(i=1; i<=nlstate;i++)              bh[mi][i]=ju;
             for(j=1; j<=nlstate+ndeath;j++)            }
               fprintf(ficrespij," %1d-%1d",i,j);            if(dh[mi][i]==0){
           fprintf(ficrespij,"\n");              dh[mi][i]=1; /* At least one step */
           for (h=0; h<=nhstepm; h++){              bh[mi][i]=ju; /* At least one step */
             fprintf(ficrespij,"%d %.0f %.0f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );              /*  printf(" bh=%d ju=%d jl=%d dh=%d jk=%d stepm=%d %d\n",bh[mi][i],ju,jl,dh[mi][i],jk,stepm,i);*/
             for(i=1; i<=nlstate;i++)            }
               for(j=1; j<=nlstate+ndeath;j++)          } /* end if mle */
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);        }
             fprintf(ficrespij,"\n");      } /* end wave */
           }    }
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    jmean=sum/k;
           fprintf(ficrespij,"\n");    printf("Delay (in months) between two waves Min=%d (for indiviudal %ld) Max=%d (%ld) Mean=%f\n\n ",jmin, num[ijmin], jmax, num[ijmax], jmean);
         }    fprintf(ficlog,"Delay (in months) between two waves Min=%d (for indiviudal %ld) Max=%d (%ld) Mean=%f\n\n ",jmin, ijmin, jmax, ijmax, jmean);
     }   }
   }  
   /*********** Tricode ****************************/
   fclose(ficrespij);  void tricode(int *Tvar, int **nbcode, int imx)
   {
   /*---------- Health expectancies and variances ------------*/    /* Uses cptcovn+2*cptcovprod as the number of covariates */
     /*      Tvar[i]=atoi(stre); /* find 'n' in Vn and stores in Tvar. If model=V2+V1 Tvar[1]=2 and Tvar[2]=1 */
   strcpy(filerest,"t");  
   strcat(filerest,fileres);    int Ndum[20],ij=1, k=0, j=0, i=0, maxncov=NCOVMAX;
   if((ficrest=fopen(filerest,"w"))==NULL) {    int modmaxcovj=0; /* Modality max of covariates j */
     printf("Problem with total LE resultfile: %s\n", filerest);goto end;    cptcoveff=0; 
   }   
   printf("Computing Total LEs with variances: file '%s' \n", filerest);    for (k=0; k<maxncov; k++) Ndum[k]=0;
     for (k=1; k<=7; k++) ncodemax[k]=0; /* Horrible constant again */
   
   strcpy(filerese,"e");    for (j=1; j<=(cptcovn+2*cptcovprod); j++) { /* For each covariate j */
   strcat(filerese,fileres);      for (i=1; i<=imx; i++) { /*reads the data file to get the maximum value of the 
   if((ficreseij=fopen(filerese,"w"))==NULL) {                                 modality of this covariate Vj*/ 
     printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);        ij=(int)(covar[Tvar[j]][i]); /* ij=0 or 1 or -1. Finds for covariate j, n=Tvar[j] of Vn . ij is the
   }                                        modality of the nth covariate of individual i. */
   printf("Computing Health Expectancies: result on file '%s' \n", filerese);        Ndum[ij]++; /*counts and stores the occurence of this modality 0, 1, -1*/
         /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/
  strcpy(fileresv,"v");        if (ij > modmaxcovj) modmaxcovj=ij; 
   strcat(fileresv,fileres);        /* getting the maximum value of the modality of the covariate
   if((ficresvij=fopen(fileresv,"w"))==NULL) {           (should be 0 or 1 now) Tvar[j]. If V=sex and male is coded 0 and
     printf("Problem with variance resultfile: %s\n", fileresv);exit(0);           female is 1, then modmaxcovj=1.*/
   }      }
   printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);      /* Ndum[0] = frequency of 0 for model-covariate j, Ndum[1] frequency of 1 etc. */
       for (i=0; i<=modmaxcovj; i++) { /* i=-1 ? 0 and 1*//* For each modality of model-cov j */
   k=0;        if( Ndum[i] != 0 )
   for(cptcov=1;cptcov<=i1;cptcov++){          ncodemax[j]++; 
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){        /* Number of modalities of the j th covariate. In fact
       k=k+1;           ncodemax[j]=2 (dichotom. variables only) but it could be more for
       fprintf(ficrest,"\n#****** ");           historical reasons */
       for(j=1;j<=cptcoveff;j++)      } /* Ndum[-1] number of undefined modalities */
         fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);  
       fprintf(ficrest,"******\n");      /* j is a covariate, n=Tvar[j] of Vn; Fills nbcode */
       ij=1; 
       fprintf(ficreseij,"\n#****** ");      for (i=1; i<=ncodemax[j]; i++) { /* i= 1 to 2 for dichotomous */
       for(j=1;j<=cptcoveff;j++)        for (k=0; k<= modmaxcovj; k++) { /* k=-1 ? NCOVMAX*//* maxncov or modmaxcovj */
         fprintf(ficreseij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);          if (Ndum[k] != 0) { /* If at least one individual responded to this modality k */
       fprintf(ficreseij,"******\n");            nbcode[Tvar[j]][ij]=k;  /* stores the modality in an array nbcode. 
                                        k is a modality. If we have model=V1+V1*sex 
       fprintf(ficresvij,"\n#****** ");                                       then: nbcode[1][1]=0 ; nbcode[1][2]=1; nbcode[2][1]=0 ; nbcode[2][2]=1; */
       for(j=1;j<=cptcoveff;j++)            ij++;
         fprintf(ficresvij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);          }
       fprintf(ficresvij,"******\n");          if (ij > ncodemax[j]) break; 
         }  /* end of loop on */
       eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);      } /* end of loop on modality */ 
       oldm=oldms;savm=savms;    } /* end of loop on model-covariate j. nbcode[Tvarj][1]=0 and nbcode[Tvarj][2]=1 sets the value of covariate j*/  
       evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k);      
       vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);    for (k=0; k< maxncov; k++) Ndum[k]=0;
       oldm=oldms;savm=savms;    
       varevsij(fileres, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);    for (i=1; i<=ncovmodel-2; i++) { /* -2, cste and age */
           /* Listing of all covariables in statement model to see if some covariates appear twice. For example, V1 appears twice in V1+V1*V2.*/
       fprintf(ficrest,"#Total LEs with variances: e.. (std) ");     ij=Tvar[i]; /* Tvar might be -1 if status was unknown */
       for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);     Ndum[ij]++;
       fprintf(ficrest,"\n");   }
          
       hf=1;   ij=1;
       if (stepm >= YEARM) hf=stepm/YEARM;   for (i=1; i<= maxncov; i++) { /* modmaxcovj is unknown here. Only Ndum[2(V2),3(age*V3), 5(V3*V2) 6(V1*V4) */
       epj=vector(1,nlstate+1);     if((Ndum[i]!=0) && (i<=ncovcol)){
       for(age=bage; age <=fage ;age++){       Tvaraff[ij]=i; /*For printing */
         prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);       ij++;
         fprintf(ficrest," %.0f",age);     }
         for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){   }
           for(i=1, epj[j]=0.;i <=nlstate;i++) {   ij--;
             epj[j] += prlim[i][i]*hf*eij[i][j][(int)age];   cptcoveff=ij; /*Number of simple covariates*/
           }  }
           epj[nlstate+1] +=epj[j];  
         }  /*********** Health Expectancies ****************/
         for(i=1, vepp=0.;i <=nlstate;i++)  
           for(j=1;j <=nlstate;j++)  void evsij(double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int cij, int estepm,char strstart[] )
             vepp += vareij[i][j][(int)age];  
         fprintf(ficrest," %.2f (%.2f)", epj[nlstate+1],hf*sqrt(vepp));  {
         for(j=1;j <=nlstate;j++){    /* Health expectancies, no variances */
           fprintf(ficrest," %.2f (%.2f)", epj[j],hf*sqrt(vareij[j][j][(int)age]));    int i, j, nhstepm, hstepm, h, nstepm, k, cptj, cptj2, i2, j2;
         }    int nhstepma, nstepma; /* Decreasing with age */
         fprintf(ficrest,"\n");    double age, agelim, hf;
       }    double ***p3mat;
     }    double eip;
   }  
            pstamp(ficreseij);
  fclose(ficreseij);    fprintf(ficreseij,"# (a) Life expectancies by health status at initial age and (b) health expectancies by health status at initial age\n");
  fclose(ficresvij);    fprintf(ficreseij,"# Age");
   fclose(ficrest);    for(i=1; i<=nlstate;i++){
   fclose(ficpar);      for(j=1; j<=nlstate;j++){
   free_vector(epj,1,nlstate+1);        fprintf(ficreseij," e%1d%1d ",i,j);
   /*  scanf("%d ",i); */      }
       fprintf(ficreseij," e%1d. ",i);
   /*------- Variance limit prevalence------*/      }
     fprintf(ficreseij,"\n");
 strcpy(fileresvpl,"vpl");  
   strcat(fileresvpl,fileres);    
   if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {    if(estepm < stepm){
     printf("Problem with variance prev lim resultfile: %s\n", fileresvpl);      printf ("Problem %d lower than %d\n",estepm, stepm);
     exit(0);    }
   }    else  hstepm=estepm;   
   printf("Computing Variance-covariance of Prevalence limit: file '%s' \n", fileresvpl);    /* We compute the life expectancy from trapezoids spaced every estepm months
      * This is mainly to measure the difference between two models: for example
  k=0;     * if stepm=24 months pijx are given only every 2 years and by summing them
  for(cptcov=1;cptcov<=i1;cptcov++){     * we are calculating an estimate of the Life Expectancy assuming a linear 
    for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){     * progression in between and thus overestimating or underestimating according
      k=k+1;     * to the curvature of the survival function. If, for the same date, we 
      fprintf(ficresvpl,"\n#****** ");     * estimate the model with stepm=1 month, we can keep estepm to 24 months
      for(j=1;j<=cptcoveff;j++)     * to compare the new estimate of Life expectancy with the same linear 
        fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);     * hypothesis. A more precise result, taking into account a more precise
      fprintf(ficresvpl,"******\n");     * curvature will be obtained if estepm is as small as stepm. */
        
      varpl=matrix(1,nlstate,(int) bage, (int) fage);    /* For example we decided to compute the life expectancy with the smallest unit */
      oldm=oldms;savm=savms;    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
      varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);       nhstepm is the number of hstepm from age to agelim 
    }       nstepm is the number of stepm from age to agelin. 
  }       Look at hpijx to understand the reason of that which relies in memory size
        and note for a fixed period like estepm months */
   fclose(ficresvpl);    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
   /*---------- End : free ----------------*/       means that if the survival funtion is printed only each two years of age and if
   free_matrix(varpl,1,nlstate,(int) bage, (int)fage);       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
         results. So we changed our mind and took the option of the best precision.
   free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);    */
   free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
    
      agelim=AGESUP;
   free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);    /* If stepm=6 months */
   free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);      /* Computed by stepm unit matrices, product of hstepm matrices, stored
   free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
   free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);      
    /* nhstepm age range expressed in number of stepm */
   free_matrix(matcov,1,npar,1,npar);    nstepm=(int) rint((agelim-bage)*YEARM/stepm); /* Biggest nstepm */
   free_vector(delti,1,npar);    /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
      /* if (stepm >= YEARM) hstepm=1;*/
   free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);    nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   printf("End of Imach\n");  
   /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */    for (age=bage; age<=fage; age ++){ 
        nstepma=(int) rint((agelim-bage)*YEARM/stepm); /* Biggest nstepm */
   /* printf("Total time was %d Sec. %d uSec.\n", end_time.tv_sec -start_time.tv_sec, end_time.tv_usec -start_time.tv_usec);*/      /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
   /*printf("Total time was %d uSec.\n", total_usecs);*/      /* if (stepm >= YEARM) hstepm=1;*/
   /*------ End -----------*/      nhstepma = nstepma/hstepm;/* Expressed in hstepm, typically nhstepma=40/4=10 */
   
  end:      /* If stepm=6 months */
 #ifdef windows      /* Computed by stepm unit matrices, product of hstepma matrices, stored
  chdir(pathcd);         in an array of nhstepma length: nhstepma=10, hstepm=4, stepm=6 months */
 #endif      
  system("wgnuplot graph.plt");      hpxij(p3mat,nhstepma,age,hstepm,x,nlstate,stepm,oldm, savm, cij);  
       
 #ifdef windows      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
   while (z[0] != 'q') {      
     chdir(pathcd);      printf("%d|",(int)age);fflush(stdout);
     printf("\nType e to edit output files, c to start again, and q for exiting: ");      fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
     scanf("%s",z);      
     if (z[0] == 'c') system("./imach");      /* Computing expectancies */
     else if (z[0] == 'e') {      for(i=1; i<=nlstate;i++)
       chdir(path);        for(j=1; j<=nlstate;j++)
       system("index.htm");          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
     }            eij[i][j][(int)age] += (p3mat[i][j][h]+p3mat[i][j][h+1])/2.0*hf;
     else if (z[0] == 'q') exit(0);            
   }            /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
 #endif  
 }          }
   
       fprintf(ficreseij,"%3.0f",age );
       for(i=1; i<=nlstate;i++){
         eip=0;
         for(j=1; j<=nlstate;j++){
           eip +=eij[i][j][(int)age];
           fprintf(ficreseij,"%9.4f", eij[i][j][(int)age] );
         }
         fprintf(ficreseij,"%9.4f", eip );
       }
       fprintf(ficreseij,"\n");
       
     }
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     printf("\n");
     fprintf(ficlog,"\n");
     
   }
   
   void cvevsij(double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int cij, int estepm,double delti[],double **matcov,char strstart[] )
   
   {
     /* Covariances of health expectancies eij and of total life expectancies according
      to initial status i, ei. .
     */
     int i, j, nhstepm, hstepm, h, nstepm, k, cptj, cptj2, i2, j2, ij, ji;
     int nhstepma, nstepma; /* Decreasing with age */
     double age, agelim, hf;
     double ***p3matp, ***p3matm, ***varhe;
     double **dnewm,**doldm;
     double *xp, *xm;
     double **gp, **gm;
     double ***gradg, ***trgradg;
     int theta;
   
     double eip, vip;
   
     varhe=ma3x(1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int) fage);
     xp=vector(1,npar);
     xm=vector(1,npar);
     dnewm=matrix(1,nlstate*nlstate,1,npar);
     doldm=matrix(1,nlstate*nlstate,1,nlstate*nlstate);
     
     pstamp(ficresstdeij);
     fprintf(ficresstdeij,"# Health expectancies with standard errors\n");
     fprintf(ficresstdeij,"# Age");
     for(i=1; i<=nlstate;i++){
       for(j=1; j<=nlstate;j++)
         fprintf(ficresstdeij," e%1d%1d (SE)",i,j);
       fprintf(ficresstdeij," e%1d. ",i);
     }
     fprintf(ficresstdeij,"\n");
   
     pstamp(ficrescveij);
     fprintf(ficrescveij,"# Subdiagonal matrix of covariances of health expectancies by age: cov(eij,ekl)\n");
     fprintf(ficrescveij,"# Age");
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=nlstate;j++){
         cptj= (j-1)*nlstate+i;
         for(i2=1; i2<=nlstate;i2++)
           for(j2=1; j2<=nlstate;j2++){
             cptj2= (j2-1)*nlstate+i2;
             if(cptj2 <= cptj)
               fprintf(ficrescveij,"  %1d%1d,%1d%1d",i,j,i2,j2);
           }
       }
     fprintf(ficrescveij,"\n");
     
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
     /* We compute the life expectancy from trapezoids spaced every estepm months
      * This is mainly to measure the difference between two models: for example
      * if stepm=24 months pijx are given only every 2 years and by summing them
      * we are calculating an estimate of the Life Expectancy assuming a linear 
      * progression in between and thus overestimating or underestimating according
      * to the curvature of the survival function. If, for the same date, we 
      * estimate the model with stepm=1 month, we can keep estepm to 24 months
      * to compare the new estimate of Life expectancy with the same linear 
      * hypothesis. A more precise result, taking into account a more precise
      * curvature will be obtained if estepm is as small as stepm. */
   
     /* For example we decided to compute the life expectancy with the smallest unit */
     /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
        nhstepm is the number of hstepm from age to agelim 
        nstepm is the number of stepm from age to agelin. 
        Look at hpijx to understand the reason of that which relies in memory size
        and note for a fixed period like estepm months */
     /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
        means that if the survival funtion is printed only each two years of age and if
        you sum them up and add 1 year (area under the trapezoids) you won't get the same 
        results. So we changed our mind and took the option of the best precision.
     */
     hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
   
     /* If stepm=6 months */
     /* nhstepm age range expressed in number of stepm */
     agelim=AGESUP;
     nstepm=(int) rint((agelim-bage)*YEARM/stepm); 
     /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
     /* if (stepm >= YEARM) hstepm=1;*/
     nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
     
     p3matp=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     p3matm=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate*nlstate);
     trgradg =ma3x(0,nhstepm,1,nlstate*nlstate,1,npar);
     gp=matrix(0,nhstepm,1,nlstate*nlstate);
     gm=matrix(0,nhstepm,1,nlstate*nlstate);
   
     for (age=bage; age<=fage; age ++){ 
       nstepma=(int) rint((agelim-bage)*YEARM/stepm); /* Biggest nstepm */
       /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
       /* if (stepm >= YEARM) hstepm=1;*/
       nhstepma = nstepma/hstepm;/* Expressed in hstepm, typically nhstepma=40/4=10 */
   
       /* If stepm=6 months */
       /* Computed by stepm unit matrices, product of hstepma matrices, stored
          in an array of nhstepma length: nhstepma=10, hstepm=4, stepm=6 months */
       
       hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
   
       /* Computing  Variances of health expectancies */
       /* Gradient is computed with plus gp and minus gm. Code is duplicated in order to
          decrease memory allocation */
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ 
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
           xm[i] = x[i] - (i==theta ?delti[theta]:0);
         }
         hpxij(p3matp,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, cij);  
         hpxij(p3matm,nhstepm,age,hstepm,xm,nlstate,stepm,oldm,savm, cij);  
     
         for(j=1; j<= nlstate; j++){
           for(i=1; i<=nlstate; i++){
             for(h=0; h<=nhstepm-1; h++){
               gp[h][(j-1)*nlstate + i] = (p3matp[i][j][h]+p3matp[i][j][h+1])/2.;
               gm[h][(j-1)*nlstate + i] = (p3matm[i][j][h]+p3matm[i][j][h+1])/2.;
             }
           }
         }
        
         for(ij=1; ij<= nlstate*nlstate; ij++)
           for(h=0; h<=nhstepm-1; h++){
             gradg[h][theta][ij]= (gp[h][ij]-gm[h][ij])/2./delti[theta];
           }
       }/* End theta */
       
       
       for(h=0; h<=nhstepm-1; h++)
         for(j=1; j<=nlstate*nlstate;j++)
           for(theta=1; theta <=npar; theta++)
             trgradg[h][j][theta]=gradg[h][theta][j];
       
   
        for(ij=1;ij<=nlstate*nlstate;ij++)
         for(ji=1;ji<=nlstate*nlstate;ji++)
           varhe[ij][ji][(int)age] =0.;
   
        printf("%d|",(int)age);fflush(stdout);
        fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
        for(h=0;h<=nhstepm-1;h++){
         for(k=0;k<=nhstepm-1;k++){
           matprod2(dnewm,trgradg[h],1,nlstate*nlstate,1,npar,1,npar,matcov);
           matprod2(doldm,dnewm,1,nlstate*nlstate,1,npar,1,nlstate*nlstate,gradg[k]);
           for(ij=1;ij<=nlstate*nlstate;ij++)
             for(ji=1;ji<=nlstate*nlstate;ji++)
               varhe[ij][ji][(int)age] += doldm[ij][ji]*hf*hf;
         }
       }
   
       /* Computing expectancies */
       hpxij(p3matm,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, cij);  
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++)
           for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
             eij[i][j][(int)age] += (p3matm[i][j][h]+p3matm[i][j][h+1])/2.0*hf;
             
             /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
   
           }
   
       fprintf(ficresstdeij,"%3.0f",age );
       for(i=1; i<=nlstate;i++){
         eip=0.;
         vip=0.;
         for(j=1; j<=nlstate;j++){
           eip += eij[i][j][(int)age];
           for(k=1; k<=nlstate;k++) /* Sum on j and k of cov(eij,eik) */
             vip += varhe[(j-1)*nlstate+i][(k-1)*nlstate+i][(int)age];
           fprintf(ficresstdeij," %9.4f (%.4f)", eij[i][j][(int)age], sqrt(varhe[(j-1)*nlstate+i][(j-1)*nlstate+i][(int)age]) );
         }
         fprintf(ficresstdeij," %9.4f (%.4f)", eip, sqrt(vip));
       }
       fprintf(ficresstdeij,"\n");
   
       fprintf(ficrescveij,"%3.0f",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           cptj= (j-1)*nlstate+i;
           for(i2=1; i2<=nlstate;i2++)
             for(j2=1; j2<=nlstate;j2++){
               cptj2= (j2-1)*nlstate+i2;
               if(cptj2 <= cptj)
                 fprintf(ficrescveij," %.4f", varhe[cptj][cptj2][(int)age]);
             }
         }
       fprintf(ficrescveij,"\n");
      
     }
     free_matrix(gm,0,nhstepm,1,nlstate*nlstate);
     free_matrix(gp,0,nhstepm,1,nlstate*nlstate);
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate*nlstate);
     free_ma3x(trgradg,0,nhstepm,1,nlstate*nlstate,1,npar);
     free_ma3x(p3matm,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     free_ma3x(p3matp,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     printf("\n");
     fprintf(ficlog,"\n");
   
     free_vector(xm,1,npar);
     free_vector(xp,1,npar);
     free_matrix(dnewm,1,nlstate*nlstate,1,npar);
     free_matrix(doldm,1,nlstate*nlstate,1,nlstate*nlstate);
     free_ma3x(varhe,1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int)fage);
   }
   
   /************ Variance ******************/
   void varevsij(char optionfilefiname[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, int estepm, int cptcov, int cptcod, int popbased, int mobilav, char strstart[])
   {
     /* Variance of health expectancies */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/
     /* double **newm;*/
     double **dnewm,**doldm;
     double **dnewmp,**doldmp;
     int i, j, nhstepm, hstepm, h, nstepm ;
     int k, cptcode;
     double *xp;
     double **gp, **gm;  /* for var eij */
     double ***gradg, ***trgradg; /*for var eij */
     double **gradgp, **trgradgp; /* for var p point j */
     double *gpp, *gmp; /* for var p point j */
     double **varppt; /* for var p point j nlstate to nlstate+ndeath */
     double ***p3mat;
     double age,agelim, hf;
     double ***mobaverage;
     int theta;
     char digit[4];
     char digitp[25];
   
     char fileresprobmorprev[FILENAMELENGTH];
   
     if(popbased==1){
       if(mobilav!=0)
         strcpy(digitp,"-populbased-mobilav-");
       else strcpy(digitp,"-populbased-nomobil-");
     }
     else 
       strcpy(digitp,"-stablbased-");
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     strcpy(fileresprobmorprev,"prmorprev"); 
     sprintf(digit,"%-d",ij);
     /*printf("DIGIT=%s, ij=%d ijr=%-d|\n",digit, ij,ij);*/
     strcat(fileresprobmorprev,digit); /* Tvar to be done */
     strcat(fileresprobmorprev,digitp); /* Popbased or not, mobilav or not */
     strcat(fileresprobmorprev,fileres);
     if((ficresprobmorprev=fopen(fileresprobmorprev,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobmorprev);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobmorprev);
     }
     printf("Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
    
     fprintf(ficlog,"Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
     pstamp(ficresprobmorprev);
     fprintf(ficresprobmorprev,"# probabilities of dying before estepm=%d months for people of exact age and weighted probabilities w1*p1j+w2*p2j+... stand dev in()\n",estepm);
     fprintf(ficresprobmorprev,"# Age cov=%-d",ij);
     for(j=nlstate+1; j<=(nlstate+ndeath);j++){
       fprintf(ficresprobmorprev," p.%-d SE",j);
       for(i=1; i<=nlstate;i++)
         fprintf(ficresprobmorprev," w%1d p%-d%-d",i,i,j);
     }  
     fprintf(ficresprobmorprev,"\n");
     fprintf(ficgp,"\n# Routine varevsij");
     /* fprintf(fichtm, "#Local time at start: %s", strstart);*/
     fprintf(fichtm,"\n<li><h4> Computing probabilities of dying over estepm months as a weighted average (i.e global mortality independent of initial healh state)</h4></li>\n");
     fprintf(fichtm,"\n<br>%s  <br>\n",digitp);
   /*   } */
     varppt = matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     pstamp(ficresvij);
     fprintf(ficresvij,"# Variance and covariance of health expectancies e.j \n#  (weighted average of eij where weights are ");
     if(popbased==1)
       fprintf(ficresvij,"the age specific prevalence observed (cross-sectionally) in the population i.e cross-sectionally\n in each health state (popbased=1) (mobilav=%d\n",mobilav);
     else
       fprintf(ficresvij,"the age specific period (stable) prevalences in each health state \n");
     fprintf(ficresvij,"# Age");
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=nlstate;j++)
         fprintf(ficresvij," Cov(e.%1d, e.%1d)",i,j);
     fprintf(ficresvij,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     dnewmp= matrix(nlstate+1,nlstate+ndeath,1,npar);
     doldmp= matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
   
     gradgp=matrix(1,npar,nlstate+1,nlstate+ndeath);
     gpp=vector(nlstate+1,nlstate+ndeath);
     gmp=vector(nlstate+1,nlstate+ndeath);
     trgradgp =matrix(nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
     /* For example we decided to compute the life expectancy with the smallest unit */
     /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
        nhstepm is the number of hstepm from age to agelim 
        nstepm is the number of stepm from age to agelin. 
        Look at function hpijx to understand why (it is linked to memory size questions) */
     /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
        means that if the survival funtion is printed every two years of age and if
        you sum them up and add 1 year (area under the trapezoids) you won't get the same 
        results. So we changed our mind and took the option of the best precision.
     */
     hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       gradg=ma3x(0,nhstepm,1,npar,1,nlstate);
       gp=matrix(0,nhstepm,1,nlstate);
       gm=matrix(0,nhstepm,1,nlstate);
   
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient x + delta*/
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
   
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
     
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gp[h][j]=0.;i<=nlstate;i++)
               gp[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gpp[j]=0.; i<= nlstate; i++)
             gpp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(i=1; i<=npar; i++) /* Computes gradient x - delta */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
    
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
   
         for(j=1; j<= nlstate; j++){  /* Sum of wi * eij = e.j */
           for(h=0; h<=nhstepm; h++){
             for(i=1, gm[h][j]=0.;i<=nlstate;i++)
               gm[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gmp[j]=0.; i<= nlstate; i++)
            gmp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(j=1; j<= nlstate; j++) /* vareij */
           for(h=0; h<=nhstepm; h++){
             gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
           }
   
         for(j=nlstate+1; j<= nlstate+ndeath; j++){ /* var mu */
           gradgp[theta][j]= (gpp[j]-gmp[j])/2./delti[theta];
         }
   
       } /* End theta */
   
       trgradg =ma3x(0,nhstepm,1,nlstate,1,npar); /* veij */
   
       for(h=0; h<=nhstepm; h++) /* veij */
         for(j=1; j<=nlstate;j++)
           for(theta=1; theta <=npar; theta++)
             trgradg[h][j][theta]=gradg[h][theta][j];
   
       for(j=nlstate+1; j<=nlstate+ndeath;j++) /* mu */
         for(theta=1; theta <=npar; theta++)
           trgradgp[j][theta]=gradgp[theta][j];
     
   
       hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
       for(i=1;i<=nlstate;i++)
         for(j=1;j<=nlstate;j++)
           vareij[i][j][(int)age] =0.;
   
       for(h=0;h<=nhstepm;h++){
         for(k=0;k<=nhstepm;k++){
           matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);
           matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);
           for(i=1;i<=nlstate;i++)
             for(j=1;j<=nlstate;j++)
               vareij[i][j][(int)age] += doldm[i][j]*hf*hf;
         }
       }
     
       /* pptj */
       matprod2(dnewmp,trgradgp,nlstate+1,nlstate+ndeath,1,npar,1,npar,matcov);
       matprod2(doldmp,dnewmp,nlstate+1,nlstate+ndeath,1,npar,nlstate+1,nlstate+ndeath,gradgp);
       for(j=nlstate+1;j<=nlstate+ndeath;j++)
         for(i=nlstate+1;i<=nlstate+ndeath;i++)
           varppt[j][i]=doldmp[j][i];
       /* end ppptj */
       /*  x centered again */
       hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm,savm, ij);  
       prevalim(prlim,nlstate,x,age,oldm,savm,ftolpl,ij);
    
       if (popbased==1) {
         if(mobilav ==0){
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=probs[(int)age][i][ij];
         }else{ /* mobilav */ 
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=mobaverage[(int)age][i][ij];
         }
       }
                
       /* This for computing probability of death (h=1 means
          computed over hstepm (estepm) matrices product = hstepm*stepm months) 
          as a weighted average of prlim.
       */
       for(j=nlstate+1;j<=nlstate+ndeath;j++){
         for(i=1,gmp[j]=0.;i<= nlstate; i++) 
           gmp[j] += prlim[i][i]*p3mat[i][j][1]; 
       }    
       /* end probability of death */
   
       fprintf(ficresprobmorprev,"%3d %d ",(int) age, ij);
       for(j=nlstate+1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprobmorprev," %11.3e %11.3e",gmp[j], sqrt(varppt[j][j]));
         for(i=1; i<=nlstate;i++){
           fprintf(ficresprobmorprev," %11.3e %11.3e ",prlim[i][i],p3mat[i][j][1]);
         }
       } 
       fprintf(ficresprobmorprev,"\n");
   
       fprintf(ficresvij,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           fprintf(ficresvij," %.4f", vareij[i][j][(int)age]);
         }
       fprintf(ficresvij,"\n");
       free_matrix(gp,0,nhstepm,1,nlstate);
       free_matrix(gm,0,nhstepm,1,nlstate);
       free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);
       free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);
       free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     } /* End age */
     free_vector(gpp,nlstate+1,nlstate+ndeath);
     free_vector(gmp,nlstate+1,nlstate+ndeath);
     free_matrix(gradgp,1,npar,nlstate+1,nlstate+ndeath);
     free_matrix(trgradgp,nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     fprintf(ficgp,"\nunset parametric;unset label; set ter png small;set size 0.65, 0.65");
     /* for(j=nlstate+1; j<= nlstate+ndeath; j++){ *//* Only the first actually */
     fprintf(ficgp,"\n set log y; unset log x;set xlabel \"Age\"; set ylabel \"Force of mortality (year-1)\";");
   /*   fprintf(ficgp,"\n plot \"%s\"  u 1:($3*%6.3f) not w l 1 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)*%6.3f) t \"95\%% interval\" w l 2 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)*%6.3f) not w l 2 ",fileresprobmorprev,YEARM/estepm); */
     fprintf(ficgp,"\n plot \"%s\"  u 1:($3) not w l 1 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)) t \"95\%% interval\" w l 2 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)) not w l 2 ",subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> File (multiple files are possible if covariates are present): <A href=\"%s\">%s</a>\n",subdirf(fileresprobmorprev),subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months. <br> <img src=\"%s%s.png\"> <br>\n", estepm,subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
     /*  fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months and then divided by estepm and multiplied by %.0f in order to have the probability to die over a year <br> <img src=\"varmuptjgr%s%s.png\"> <br>\n", stepm,YEARM,digitp,digit);
   */
   /*   fprintf(ficgp,"\nset out \"varmuptjgr%s%s%s.png\";replot;",digitp,optionfilefiname,digit); */
     fprintf(ficgp,"\nset out \"%s%s.png\";replot;\n",subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,nlstate);
     free_matrix(dnewm,1,nlstate,1,npar);
     free_matrix(doldmp,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     free_matrix(dnewmp,nlstate+1,nlstate+ndeath,1,npar);
     free_matrix(varppt,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficresprobmorprev);
     fflush(ficgp);
     fflush(fichtm); 
   }  /* end varevsij */
   
   /************ Variance of prevlim ******************/
   void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, char strstart[])
   {
     /* Variance of prevalence limit */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/
     double **newm;
     double **dnewm,**doldm;
     int i, j, nhstepm, hstepm;
     int k, cptcode;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double age,agelim;
     int theta;
     
     pstamp(ficresvpl);
     fprintf(ficresvpl,"# Standard deviation of period (stable) prevalences \n");
     fprintf(ficresvpl,"# Age");
     for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %1d-%1d",i,i);
     fprintf(ficresvpl,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     
     hstepm=1*YEARM; /* Every year of age */
     hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       if (stepm >= YEARM) hstepm=1;
       nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
       gradg=matrix(1,npar,1,nlstate);
       gp=vector(1,nlstate);
       gm=vector(1,nlstate);
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient */
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gp[i] = prlim[i][i];
       
         for(i=1; i<=npar; i++) /* Computes gradient */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gm[i] = prlim[i][i];
   
         for(i=1;i<=nlstate;i++)
           gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];
       } /* End theta */
   
       trgradg =matrix(1,nlstate,1,npar);
   
       for(j=1; j<=nlstate;j++)
         for(theta=1; theta <=npar; theta++)
           trgradg[j][theta]=gradg[theta][j];
   
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] =0.;
       matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);
       matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */
   
       fprintf(ficresvpl,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));
       fprintf(ficresvpl,"\n");
       free_vector(gp,1,nlstate);
       free_vector(gm,1,nlstate);
       free_matrix(gradg,1,npar,1,nlstate);
       free_matrix(trgradg,1,nlstate,1,npar);
     } /* End age */
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,npar);
     free_matrix(dnewm,1,nlstate,1,nlstate);
   
   }
   
   /************ Variance of one-step probabilities  ******************/
   void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[])
   {
     int i, j=0,  i1, k1, l1, t, tj;
     int k2, l2, j1,  z1;
     int k=0,l, cptcode;
     int first=1, first1;
     double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp;
     double **dnewm,**doldm;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double **mu;
     double age,agelim, cov[NCOVMAX];
     double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */
     int theta;
     char fileresprob[FILENAMELENGTH];
     char fileresprobcov[FILENAMELENGTH];
     char fileresprobcor[FILENAMELENGTH];
   
     double ***varpij;
   
     strcpy(fileresprob,"prob"); 
     strcat(fileresprob,fileres);
     if((ficresprob=fopen(fileresprob,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprob);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob);
     }
     strcpy(fileresprobcov,"probcov"); 
     strcat(fileresprobcov,fileres);
     if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcov);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov);
     }
     strcpy(fileresprobcor,"probcor"); 
     strcat(fileresprobcor,fileres);
     if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcor);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor);
     }
     printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     pstamp(ficresprob);
     fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n");
     fprintf(ficresprob,"# Age");
     pstamp(ficresprobcov);
     fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n");
     fprintf(ficresprobcov,"# Age");
     pstamp(ficresprobcor);
     fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n");
     fprintf(ficresprobcor,"# Age");
   
   
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprob," p%1d-%1d (SE)",i,j);
         fprintf(ficresprobcov," p%1d-%1d ",i,j);
         fprintf(ficresprobcor," p%1d-%1d ",i,j);
       }  
    /* fprintf(ficresprob,"\n");
     fprintf(ficresprobcov,"\n");
     fprintf(ficresprobcor,"\n");
    */
     xp=vector(1,npar);
     dnewm=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
     doldm=matrix(1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     mu=matrix(1,(nlstate)*(nlstate+ndeath), (int) bage, (int)fage);
     varpij=ma3x(1,nlstate*(nlstate+ndeath),1,nlstate*(nlstate+ndeath),(int) bage, (int) fage);
     first=1;
     fprintf(ficgp,"\n# Routine varprob");
     fprintf(fichtm,"\n<li><h4> Computing and drawing one step probabilities with their confidence intervals</h4></li>\n");
     fprintf(fichtm,"\n");
   
     fprintf(fichtm,"\n<li><h4> <a href=\"%s\">Matrix of variance-covariance of pairs of step probabilities (drawings)</a></h4></li>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\n<h4>Matrix of variance-covariance of pairs of step probabilities</h4>\n\
     file %s<br>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (p<inf>ij</inf>, p<inf>kl</inf>) are estimated\
   and drawn. It helps understanding how is the covariance between two incidences.\
    They are expressed in year<sup>-1</sup> in order to be less dependent of stepm.<br>\n");
     fprintf(fichtmcov,"\n<br> Contour plot corresponding to x'cov<sup>-1</sup>x = 4 (where x is the column vector (pij,pkl)) are drawn. \
   It can be understood this way: if pij and pkl where uncorrelated the (2x2) matrix of covariance \
   would have been (1/(var pij), 0 , 0, 1/(var pkl)), and the confidence interval would be 2 \
   standard deviations wide on each axis. <br>\
    Now, if both incidences are correlated (usual case) we diagonalised the inverse of the covariance matrix\
    and made the appropriate rotation to look at the uncorrelated principal directions.<br>\
   To be simple, these graphs help to understand the significativity of each parameter in relation to a second other one.<br> \n");
   
     cov[1]=1;
     tj=cptcoveff;
     if (cptcovn<1) {tj=1;ncodemax[1]=1;}
     j1=0;
     for(t=1; t<=tj;t++){
       for(i1=1; i1<=ncodemax[t];i1++){ 
         j1++;
         if  (cptcovn>0) {
           fprintf(ficresprob, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprob, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprob, "**********\n#\n");
           fprintf(ficresprobcov, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcov, "**********\n#\n");
           
           fprintf(ficgp, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficgp, " V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficgp, "**********\n#\n");
           
           
           fprintf(fichtmcov, "\n<hr  size=\"2\" color=\"#EC5E5E\">********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(fichtmcov, "**********\n<hr size=\"2\" color=\"#EC5E5E\">");
           
           fprintf(ficresprobcor, "\n#********** Variable ");    
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcor, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcor, "**********\n#");    
         }
         
         for (age=bage; age<=fage; age ++){ 
           cov[2]=age;
           for (k=1; k<=cptcovn;k++) {
             cov[2+k]=nbcode[Tvar[k]][codtab[j1][Tvar[k]]];
           }
           for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
           for (k=1; k<=cptcovprod;k++)
             cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
           
           gradg=matrix(1,npar,1,(nlstate)*(nlstate+ndeath));
           trgradg=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
           gp=vector(1,(nlstate)*(nlstate+ndeath));
           gm=vector(1,(nlstate)*(nlstate+ndeath));
       
           for(theta=1; theta <=npar; theta++){
             for(i=1; i<=npar; i++)
               xp[i] = x[i] + (i==theta ?delti[theta]:(double)0);
             
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             
             k=0;
             for(i=1; i<= (nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gp[k]=pmmij[i][j];
               }
             }
             
             for(i=1; i<=npar; i++)
               xp[i] = x[i] - (i==theta ?delti[theta]:(double)0);
       
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             k=0;
             for(i=1; i<=(nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gm[k]=pmmij[i][j];
               }
             }
        
             for(i=1; i<= (nlstate)*(nlstate+ndeath); i++) 
               gradg[theta][i]=(gp[i]-gm[i])/(double)2./delti[theta];  
           }
   
           for(j=1; j<=(nlstate)*(nlstate+ndeath);j++)
             for(theta=1; theta <=npar; theta++)
               trgradg[j][theta]=gradg[theta][j];
           
           matprod2(dnewm,trgradg,1,(nlstate)*(nlstate+ndeath),1,npar,1,npar,matcov); 
           matprod2(doldm,dnewm,1,(nlstate)*(nlstate+ndeath),1,npar,1,(nlstate)*(nlstate+ndeath),gradg);
           free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
           free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
   
           pmij(pmmij,cov,ncovmodel,x,nlstate);
           
           k=0;
           for(i=1; i<=(nlstate); i++){
             for(j=1; j<=(nlstate+ndeath);j++){
               k=k+1;
               mu[k][(int) age]=pmmij[i][j];
             }
           }
           for(i=1;i<=(nlstate)*(nlstate+ndeath);i++)
             for(j=1;j<=(nlstate)*(nlstate+ndeath);j++)
               varpij[i][j][(int)age] = doldm[i][j];
   
           /*printf("\n%d ",(int)age);
             for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             fprintf(ficlog,"%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             }*/
   
           fprintf(ficresprob,"\n%d ",(int)age);
           fprintf(ficresprobcov,"\n%d ",(int)age);
           fprintf(ficresprobcor,"\n%d ",(int)age);
   
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++)
             fprintf(ficresprob,"%11.3e (%11.3e) ",mu[i][(int) age],sqrt(varpij[i][i][(int)age]));
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             fprintf(ficresprobcov,"%11.3e ",mu[i][(int) age]);
             fprintf(ficresprobcor,"%11.3e ",mu[i][(int) age]);
           }
           i=0;
           for (k=1; k<=(nlstate);k++){
             for (l=1; l<=(nlstate+ndeath);l++){ 
               i=i++;
               fprintf(ficresprobcov,"\n%d %d-%d",(int)age,k,l);
               fprintf(ficresprobcor,"\n%d %d-%d",(int)age,k,l);
               for (j=1; j<=i;j++){
                 fprintf(ficresprobcov," %11.3e",varpij[i][j][(int)age]);
                 fprintf(ficresprobcor," %11.3e",varpij[i][j][(int) age]/sqrt(varpij[i][i][(int) age])/sqrt(varpij[j][j][(int)age]));
               }
             }
           }/* end of loop for state */
         } /* end of loop for age */
   
         /* Confidence intervalle of pij  */
         /*
           fprintf(ficgp,"\nunset parametric;unset label");
           fprintf(ficgp,"\nset log y;unset log x; set xlabel \"Age\";set ylabel \"probability (year-1)\"");
           fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
           fprintf(fichtm,"\n<br>Probability with  confidence intervals expressed in year<sup>-1</sup> :<a href=\"pijgr%s.png\">pijgr%s.png</A>, ",optionfilefiname,optionfilefiname);
           fprintf(fichtm,"\n<br><img src=\"pijgr%s.png\"> ",optionfilefiname);
           fprintf(ficgp,"\nset out \"pijgr%s.png\"",optionfilefiname);
           fprintf(ficgp,"\nplot \"%s\" every :::%d::%d u 1:2 \"\%%lf",k1,k2,xfilevarprob);
         */
   
         /* Drawing ellipsoids of confidence of two variables p(k1-l1,k2-l2)*/
         first1=1;
         for (k2=1; k2<=(nlstate);k2++){
           for (l2=1; l2<=(nlstate+ndeath);l2++){ 
             if(l2==k2) continue;
             j=(k2-1)*(nlstate+ndeath)+l2;
             for (k1=1; k1<=(nlstate);k1++){
               for (l1=1; l1<=(nlstate+ndeath);l1++){ 
                 if(l1==k1) continue;
                 i=(k1-1)*(nlstate+ndeath)+l1;
                 if(i<=j) continue;
                 for (age=bage; age<=fage; age ++){ 
                   if ((int)age %5==0){
                     v1=varpij[i][i][(int)age]/stepm*YEARM/stepm*YEARM;
                     v2=varpij[j][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     cv12=varpij[i][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     mu1=mu[i][(int) age]/stepm*YEARM ;
                     mu2=mu[j][(int) age]/stepm*YEARM;
                     c12=cv12/sqrt(v1*v2);
                     /* Computing eigen value of matrix of covariance */
                     lc1=((v1+v2)+sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     lc2=((v1+v2)-sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     if ((lc2 <0) || (lc1 <0) ){
                       printf("Error: One eigen value of 2x2 matrix of covariance is negative, lc1=%11.3e, lc2=%11.3e, v1=%11.3e, v2=%11.3e, cv12=%11.3e.\n It means that the matrix was not well estimated (varpij), for i=%2d, j=%2d, age=%4d .\n See files %s and %s. Continuing by making them positive: WRONG RESULTS.\n", lc1, lc2, v1, v2, cv12, i, j, (int)age,fileresprobcov, fileresprobcor);
                       fprintf(ficlog,"Error: One eigen value of 2x2 matrix of covariance is negative, lc1=%11.3e, lc2=%11.3e, v1=%11.3e, v2=%11.3e, cv12=%11.3e\n", lc1, lc2, v1, v2, cv12);fflush(ficlog);
                       lc1=fabs(lc1);
                       lc2=fabs(lc2);
                     }
   
                     /* Eigen vectors */
                     v11=(1./sqrt(1+(v1-lc1)*(v1-lc1)/cv12/cv12));
                     /*v21=sqrt(1.-v11*v11); *//* error */
                     v21=(lc1-v1)/cv12*v11;
                     v12=-v21;
                     v22=v11;
                     tnalp=v21/v11;
                     if(first1==1){
                       first1=0;
                       printf("%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tang %.3f\nOthers in log...\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     }
                     fprintf(ficlog,"%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tan %.3f\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     /*printf(fignu*/
                     /* mu1+ v11*lc1*cost + v12*lc2*sin(t) */
                     /* mu2+ v21*lc1*cost + v22*lc2*sin(t) */
                     if(first==1){
                       first=0;
                       fprintf(ficgp,"\nset parametric;unset label");
                       fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2);
                       fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
                       fprintf(fichtmcov,"\n<br>Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year<sup>-1</sup>\
    :<a href=\"%s%d%1d%1d-%1d%1d.png\">\
   %s%d%1d%1d-%1d%1d.png</A>, ",k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br><img src=\"%s%d%1d%1d-%1d%1d.png\"> ",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br> Correlation at age %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\"",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }else{
                       first=0;
                       fprintf(fichtmcov," %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }/* if first */
                   } /* age mod 5 */
                 } /* end loop age */
                 fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\";replot;",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                 first=1;
               } /*l12 */
             } /* k12 */
           } /*l1 */
         }/* k1 */
       } /* loop covariates */
     }
     free_ma3x(varpij,1,nlstate,1,nlstate+ndeath,(int) bage, (int)fage);
     free_matrix(mu,1,(nlstate+ndeath)*(nlstate+ndeath),(int) bage, (int)fage);
     free_matrix(doldm,1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     free_matrix(dnewm,1,(nlstate)*(nlstate+ndeath),1,npar);
     free_vector(xp,1,npar);
     fclose(ficresprob);
     fclose(ficresprobcov);
     fclose(ficresprobcor);
     fflush(ficgp);
     fflush(fichtmcov);
   }
   
   
   /******************* Printing html file ***********/
   void printinghtml(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,int jmin, int jmax, double jmeanint,char rfileres[],\
                     int popforecast, int estepm ,\
                     double jprev1, double mprev1,double anprev1, \
                     double jprev2, double mprev2,double anprev2){
     int jj1, k1, i1, cpt;
   
      fprintf(fichtm,"<ul><li><a href='#firstorder'>Result files (first order: no variance)</a>\n \
      <li><a href='#secondorder'>Result files (second order (variance)</a>\n \
   </ul>");
      fprintf(fichtm,"<ul><li><h4><a name='firstorder'>Result files (first order: no variance)</a></h4>\n \
    - Observed prevalence in each state (during the period defined between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf): <a href=\"%s\">%s</a> <br>\n ",
              jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,subdirf2(fileres,"p"),subdirf2(fileres,"p"));
      fprintf(fichtm,"\
    - Estimated transition probabilities over %d (stepm) months: <a href=\"%s\">%s</a><br>\n ",
              stepm,subdirf2(fileres,"pij"),subdirf2(fileres,"pij"));
      fprintf(fichtm,"\
    - Period (stable) prevalence in each health state: <a href=\"%s\">%s</a> <br>\n",
              subdirf2(fileres,"pl"),subdirf2(fileres,"pl"));
      fprintf(fichtm,"\
    - (a) Life expectancies by health status at initial age, ei. (b) health expectancies by health status at initial age, eij . If one or more covariates are included, specific tables for each value of the covariate are output in sequences within the same file (estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n",
              estepm,subdirf2(fileres,"e"),subdirf2(fileres,"e"));
      fprintf(fichtm,"\
    - Population projections by age and states: \
      <a href=\"%s\">%s</a> <br>\n</li>", subdirf2(fileres,"f"),subdirf2(fileres,"f"));
   
   fprintf(fichtm," \n<ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        /* Pij */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i, %d (stepm) months before: <a href=\"%s%d1.png\">%s%d1.png</a><br> \
   <img src=\"%s%d1.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1);     
        /* Quasi-incidences */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i %d (stepm) months\
    before but expressed in per year i.e. quasi incidences if stepm is small and probabilities too: <a href=\"%s%d2.png\">%s%d2.png</a><br> \
   <img src=\"%s%d2.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1); 
          /* Period (stable) prevalence in each health state */
          for(cpt=1; cpt<nlstate;cpt++){
            fprintf(fichtm,"<br>- Period (stable) prevalence in each health state : <a href=\"%s%d%d.png\">%s%d%d.png</a><br> \
   <img src=\"%s%d%d.png\">",subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1);
          }
        for(cpt=1; cpt<=nlstate;cpt++) {
           fprintf(fichtm,"\n<br>- Life expectancy by health state (%d) at initial age and its decomposition into health expectancies : <a href=\"%s%d%d.png\">%s%d%d.png</a> <br> \
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1);
        }
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
   
   
    fprintf(fichtm,"\
   \n<br><li><h4> <a name='secondorder'>Result files (second order: variances)</a></h4>\n\
    - Parameter file with estimated parameters and covariance matrix: <a href=\"%s\">%s</a> <br>\n", rfileres,rfileres);
   
    fprintf(fichtm," - Variance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"prob"),subdirf2(fileres,"prob"));
    fprintf(fichtm,"\
    - Variance-covariance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcov"),subdirf2(fileres,"probcov"));
   
    fprintf(fichtm,"\
    - Correlation matrix of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcor"),subdirf2(fileres,"probcor"));
    fprintf(fichtm,"\
    - Variances and covariances of health expectancies by age and <b>initial health status</b> (cov(e<sup>ij</sup>,e<sup>kl</sup>)(estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"cve"),subdirf2(fileres,"cve"));
    fprintf(fichtm,"\
    - (a) Health expectancies by health status at initial age (e<sup>ij</sup>) and standard errors (in parentheses) (b) life expectancies and standard errors (e<sup>i.</sup>=e<sup>i1</sup>+e<sup>i2</sup>+...)(estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"stde"),subdirf2(fileres,"stde"));
    fprintf(fichtm,"\
    - Variances and covariances of health expectancies by age. Status (i) based health expectancies (in state j), e<sup>ij</sup> are weighted by the period prevalences in each state i (if popbased=1, an additional computation is done using the cross-sectional prevalences, i.e population based) (estepm=%d months): <a href=\"%s\">%s</a><br>\n",
            estepm, subdirf2(fileres,"v"),subdirf2(fileres,"v"));
    fprintf(fichtm,"\
    - Total life expectancy and total health expectancies to be spent in each health state e<sup>.j</sup> with their standard errors (if popbased=1, an additional computation is done using the cross-sectional prevalences, i.e population based) (estepm=%d months): <a href=\"%s\">%s</a> <br>\n",
            estepm, subdirf2(fileres,"t"),subdirf2(fileres,"t"));
    fprintf(fichtm,"\
    - Standard deviation of period (stable) prevalences: <a href=\"%s\">%s</a> <br>\n",\
            subdirf2(fileres,"vpl"),subdirf2(fileres,"vpl"));
   
   /*  if(popforecast==1) fprintf(fichtm,"\n */
   /*  - Prevalences forecasting: <a href=\"f%s\">f%s</a> <br>\n */
   /*  - Population forecasting (if popforecast=1): <a href=\"pop%s\">pop%s</a> <br>\n */
   /*      <br>",fileres,fileres,fileres,fileres); */
   /*  else  */
   /*    fprintf(fichtm,"\n No population forecast: popforecast = %d (instead of 1) or stepm = %d (instead of 1) or model=%s (instead of .)<br><br></li>\n",popforecast, stepm, model); */
    fflush(fichtm);
    fprintf(fichtm," <ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        for(cpt=1; cpt<=nlstate;cpt++) {
          fprintf(fichtm,"<br>- Observed (cross-sectional) and period (incidence based) \
   prevalence (with 95%% confidence interval) in state (%d): %s%d%d.png <br>\
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"v"),cpt,jj1,subdirf2(optionfilefiname,"v"),cpt,jj1);  
        }
        fprintf(fichtm,"\n<br>- Total life expectancy by age and \
   health expectancies in states (1) and (2). If popbased=1 the smooth (due to the model) \
   true period expectancies (those weighted with period prevalences are also\
    drawn in addition to the population based expectancies computed using\
    observed and cahotic prevalences: %s%d.png<br>\
   <img src=\"%s%d.png\">",subdirf2(optionfilefiname,"e"),jj1,subdirf2(optionfilefiname,"e"),jj1);
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
    fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplot(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m0,cpt=0,k1=0,i=0,k=0,j=0,jk=0,k2=0,k3=0,ij=0,l=0;
     int ng=0;
   /*   if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */
   /*     printf("Problem with file %s",optionfilegnuplot); */
   /*     fprintf(ficlog,"Problem with file %s",optionfilegnuplot); */
   /*   } */
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
     m=pow(2,cptcoveff);
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
    /* 1eme*/
     for (cpt=1; cpt<= nlstate ; cpt ++) {
      for (k1=1; k1<= m ; k1 ++) {
        fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"v"),cpt,k1);
        fprintf(ficgp,"\n#set out \"v%s%d%d.png\" \n",optionfilefiname,cpt,k1);
        fprintf(ficgp,"set xlabel \"Age\" \n\
   set ylabel \"Probability\" \n\
   set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:2 \"\%%lf",ageminpar,fage,subdirf2(fileres,"vpl"),k1-1,k1-1);
   
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else        fprintf(ficgp," \%%*lf (\%%*lf)");
        }
        fprintf(ficgp,"\" t\"Period (stable) prevalence\" w l 0,\"%s\" every :::%d::%d u 1:($2+1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1);
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        } 
        fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"%s\" every :::%d::%d u 1:($2-1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1); 
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }  
        fprintf(ficgp,"\" t\"\" w l 1,\"%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",subdirf2(fileres,"p"),k1-1,k1-1,2+4*(cpt-1));
      }
     }
     /*2 eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       fprintf(ficgp,"\nset out \"%s%d.png\" \n",subdirf2(optionfilefiname,"e"),k1);
       fprintf(ficgp,"set ylabel \"Years\" \nset ter png small\nset size 0.65,0.65\nplot [%.f:%.f] ",ageminpar,fage);
       
       for (i=1; i<= nlstate+1 ; i ++) {
         k=2*i;
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:2 \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");
         else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         fprintf(ficgp,"\" t\"\" w l 0,");
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");
         else fprintf(ficgp,"\" t\"\" w l 0,");
       }
     }
     
     /*3eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<= nlstate ; cpt ++) {
         /*       k=2+nlstate*(2*cpt-2); */
         k=2+(nlstate+1)*(cpt-1);
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"exp"),cpt,k1);
         fprintf(ficgp,"set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",ageminpar,fage,subdirf2(fileres,"e"),k1-1,k1-1,k,cpt);
         /*fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d-2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d+2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           
         */
         for (i=1; i< nlstate ; i ++) {
           fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+i,cpt,i+1);
           /*      fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+2*i,cpt,i+1);*/
           
         } 
         fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d.\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+nlstate,cpt);
       }
     }
     
     /* CV preval stable (period) */
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<=nlstate ; cpt ++) {
         k=3;
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"p"),cpt,k1);
         fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\
   set ter png small\nset size 0.65,0.65\n\
   unset log y\n\
   plot [%.f:%.f] \"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",ageminpar,agemaxpar,subdirf2(fileres,"pij"),k1,k+cpt+1,k+1);
         
         for (i=1; i< nlstate ; i ++)
           fprintf(ficgp,"+$%d",k+i+1);
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);
         
         l=3+(nlstate+ndeath)*cpt;
         fprintf(ficgp,",\"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",subdirf2(fileres,"pij"),k1,l+cpt+1,l+1);
         for (i=1; i< nlstate ; i ++) {
           l=3+(nlstate+ndeath)*cpt;
           fprintf(ficgp,"+$%d",l+i+1);
         }
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);   
       } 
     }  
     
     /* proba elementaires */
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           for(j=1; j <=ncovmodel; j++){
             fprintf(ficgp,"p%d=%f ",jk,p[jk]);
             jk++; 
             fprintf(ficgp,"\n");
           }
         }
       }
      }
   
      for(ng=1; ng<=2;ng++){ /* Number of graphics: first is probabilities second is incidence per year*/
        for(jk=1; jk <=m; jk++) {
          fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"pe"),jk,ng); 
          if (ng==2)
            fprintf(ficgp,"\nset ylabel \"Quasi-incidence per year\"\n");
          else
            fprintf(ficgp,"\nset title \"Probability\"\n");
          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65\nset log y\nplot  [%.f:%.f] ",ageminpar,agemaxpar);
          i=1;
          for(k2=1; k2<=nlstate; k2++) {
            k3=i;
            for(k=1; k<=(nlstate+ndeath); k++) {
              if (k != k2){
                if(ng==2)
                  fprintf(ficgp," %f*exp(p%d+p%d*x",YEARM/stepm,i,i+1);
                else
                  fprintf(ficgp," exp(p%d+p%d*x",i,i+1);
                ij=1;
                for(j=3; j <=ncovmodel; j++) {
                  if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                    fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                    ij++;
                  }
                  else
                    fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                }
                fprintf(ficgp,")/(1");
                
                for(k1=1; k1 <=nlstate; k1++){   
                  fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);
                  ij=1;
                  for(j=3; j <=ncovmodel; j++){
                    if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                      fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                      ij++;
                    }
                    else
                      fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                  }
                  fprintf(ficgp,")");
                }
                fprintf(ficgp,") t \"p%d%d\" ", k2,k);
                if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");
                i=i+ncovmodel;
              }
            } /* end k */
          } /* end k2 */
        } /* end jk */
      } /* end ng */
      fflush(ficgp); 
   }  /* end gnuplot */
   
   
   /*************** Moving average **************/
   int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav){
   
     int i, cpt, cptcod;
     int modcovmax =1;
     int mobilavrange, mob;
     double age;
   
     modcovmax=2*cptcoveff;/* Max number of modalities. We suppose 
                              a covariate has 2 modalities */
     if (cptcovn<1) modcovmax=1; /* At least 1 pass */
   
     if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){
       if(mobilav==1) mobilavrange=5; /* default */
       else mobilavrange=mobilav;
       for (age=bage; age<=fage; age++)
         for (i=1; i<=nlstate;i++)
           for (cptcod=1;cptcod<=modcovmax;cptcod++)
             mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod];
       /* We keep the original values on the extreme ages bage, fage and for 
          fage+1 and bage-1 we use a 3 terms moving average; for fage+2 bage+2
          we use a 5 terms etc. until the borders are no more concerned. 
       */ 
       for (mob=3;mob <=mobilavrange;mob=mob+2){
         for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){
           for (i=1; i<=nlstate;i++){
             for (cptcod=1;cptcod<=modcovmax;cptcod++){
               mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod];
                 for (cpt=1;cpt<=(mob-1)/2;cpt++){
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod];
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod];
                 }
               mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob;
             }
           }
         }/* end age */
       }/* end mob */
     }else return -1;
     return 0;
   }/* End movingaverage */
   
   
   /************** Forecasting ******************/
   prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){
     /* proj1, year, month, day of starting projection 
        agemin, agemax range of age
        dateprev1 dateprev2 range of dates during which prevalence is computed
        anproj2 year of en of projection (same day and month as proj1).
     */
     int yearp, stepsize, hstepm, nhstepm, j, k, c, cptcod, i, h, i1;
     int *popage;
     double agec; /* generic age */
     double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean;
     double *popeffectif,*popcount;
     double ***p3mat;
     double ***mobaverage;
     char fileresf[FILENAMELENGTH];
   
     agelim=AGESUP;
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
    
     strcpy(fileresf,"f"); 
     strcat(fileresf,fileres);
     if((ficresf=fopen(fileresf,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", fileresf);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", fileresf);
     }
     printf("Computing forecasting: result on file '%s' \n", fileresf);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", fileresf);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
   
     hstepm=hstepm/stepm; 
     yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp  and
                                  fractional in yp1 */
     anprojmean=yp;
     yp2=modf((yp1*12),&yp);
     mprojmean=yp;
     yp1=modf((yp2*30.5),&yp);
     jprojmean=yp;
     if(jprojmean==0) jprojmean=1;
     if(mprojmean==0) jprojmean=1;
   
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
     
     fprintf(ficresf,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); 
     
     fprintf(ficresf,"#****** Routine prevforecast **\n");
   
   /*            if (h==(int)(YEARM*yearp)){ */
     for(cptcov=1, k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficresf,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficresf," V%d=%d, hpijx=probability over h years, hp.jx is weighted by observed prev ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficresf,"******\n");
         fprintf(ficresf,"# Covariate valuofcovar yearproj age");
         for(j=1; j<=nlstate+ndeath;j++){ 
           for(i=1; i<=nlstate;i++)              
             fprintf(ficresf," p%d%d",i,j);
           fprintf(ficresf," p.%d",j);
         }
         for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { 
           fprintf(ficresf,"\n");
           fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp);   
   
           for (agec=fage; agec>=(ageminpar-1); agec--){ 
             nhstepm=(int) rint((agelim-agec)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h*hstepm/YEARM*stepm ==yearp) {
                 fprintf(ficresf,"\n");
                 for(j=1;j<=cptcoveff;j++) 
                   fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
                 fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 ppij=0.;
                 for(i=1; i<=nlstate;i++) {
                   if (mobilav==1) 
                     ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod];
                   else {
                     ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod];
                   }
                   if (h*hstepm/YEARM*stepm== yearp) {
                     fprintf(ficresf," %.3f", p3mat[i][j][h]);
                   }
                 } /* end i */
                 if (h*hstepm/YEARM*stepm==yearp) {
                   fprintf(ficresf," %.3f", ppij);
                 }
               }/* end j */
             } /* end h */
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           } /* end agec */
         } /* end yearp */
       } /* end cptcod */
     } /* end  cptcov */
          
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     fclose(ficresf);
   }
   
   /************** Forecasting *****not tested NB*************/
   populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){
     
     int cpt, stepsize, hstepm, nhstepm, j,k,c, cptcod, i,h;
     int *popage;
     double calagedatem, agelim, kk1, kk2;
     double *popeffectif,*popcount;
     double ***p3mat,***tabpop,***tabpopprev;
     double ***mobaverage;
     char filerespop[FILENAMELENGTH];
   
     tabpop= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     tabpopprev= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     agelim=AGESUP;
     calagedatem=(anpyram+mpyram/12.+jpyram/365.-dateintmean)*YEARM;
     
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     
     
     strcpy(filerespop,"pop"); 
     strcat(filerespop,fileres);
     if((ficrespop=fopen(filerespop,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", filerespop);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", filerespop);
     }
     printf("Computing forecasting: result on file '%s' \n", filerespop);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", filerespop);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     
     agelim=AGESUP;
     
     hstepm=1;
     hstepm=hstepm/stepm; 
     
     if (popforecast==1) {
       if((ficpop=fopen(popfile,"r"))==NULL) {
         printf("Problem with population file : %s\n",popfile);exit(0);
         fprintf(ficlog,"Problem with population file : %s\n",popfile);exit(0);
       } 
       popage=ivector(0,AGESUP);
       popeffectif=vector(0,AGESUP);
       popcount=vector(0,AGESUP);
       
       i=1;   
       while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF) i=i+1;
      
       imx=i;
       for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];
     }
   
     for(cptcov=1,k=0;cptcov<=i2;cptcov++){
      for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficrespop,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespop," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespop,"******\n");
         fprintf(ficrespop,"# Age");
         for(j=1; j<=nlstate+ndeath;j++) fprintf(ficrespop," P.%d",j);
         if (popforecast==1)  fprintf(ficrespop," [Population]");
         
         for (cpt=0; cpt<=0;cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficrespop,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   if (mobilav==1) 
                     kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb+1][i][cptcod];
                   else {
                     kk1=kk1+p3mat[i][j][h]*probs[(int)(agedeb+1)][i][cptcod];
                   }
                 }
                 if (h==(int)(calagedatem+12*cpt)){
                   tabpop[(int)(agedeb)][j][cptcod]=kk1;
                     /*fprintf(ficrespop," %.3f", kk1);
                       if (popforecast==1) fprintf(ficrespop," [%.f]", kk1*popeffectif[(int)agedeb+1]);*/
                 }
               }
               for(i=1; i<=nlstate;i++){
                 kk1=0.;
                   for(j=1; j<=nlstate;j++){
                     kk1= kk1+tabpop[(int)(agedeb)][j][cptcod]; 
                   }
                     tabpopprev[(int)(agedeb)][i][cptcod]=tabpop[(int)(agedeb)][i][cptcod]/kk1*popeffectif[(int)(agedeb+(calagedatem+12*cpt)*hstepm/YEARM*stepm-1)];
               }
   
               if (h==(int)(calagedatem+12*cpt)) for(j=1; j<=nlstate;j++) 
                 fprintf(ficrespop," %15.2f",tabpopprev[(int)(agedeb+1)][j][cptcod]);
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
    
     /******/
   
         for (cpt=1; cpt<=(anpyram1-anpyram);cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficresf,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   kk1=kk1+p3mat[i][j][h]*tabpopprev[(int)agedeb+1][i][cptcod];    
                 }
                 if (h==(int)(calagedatem+12*cpt)) fprintf(ficresf," %15.2f", kk1);        
               }
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
      } 
     }
    
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     if (popforecast==1) {
       free_ivector(popage,0,AGESUP);
       free_vector(popeffectif,0,AGESUP);
       free_vector(popcount,0,AGESUP);
     }
     free_ma3x(tabpop,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(tabpopprev,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficrespop);
   } /* End of popforecast */
   
   int fileappend(FILE *fichier, char *optionfich)
   {
     if((fichier=fopen(optionfich,"a"))==NULL) {
       printf("Problem with file: %s\n", optionfich);
       fprintf(ficlog,"Problem with file: %s\n", optionfich);
       return (0);
     }
     fflush(fichier);
     return (1);
   }
   
   
   /**************** function prwizard **********************/
   void prwizard(int ncovmodel, int nlstate, int ndeath,  char model[], FILE *ficparo)
   {
   
     /* Wizard to print covariance matrix template */
   
     char ca[32], cb[32], cc[32];
     int i,j, k, l, li, lj, lk, ll, jj, npar, itimes;
     int numlinepar;
   
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficparo,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         /*ca[0]= k+'a'-1;ca[1]='\0';*/
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           /*        printf(" %lf",param[i][j][k]); */
           /*        fprintf(ficparo," %lf",param[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficparo,"# Scales (for hessian or gradient estimation)\n");
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/ 
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         fprintf(ficparo,"%1d%1d",i,j);
         printf("%1d%1d",i,j);
         fflush(stdout);
         for(k=1; k<=ncovmodel;k++){
           /*      printf(" %le",delti3[i][j][k]); */
           /*      fprintf(ficparo," %le",delti3[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Covariance matrix\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
     fflush(stdout);
     fprintf(ficparo,"# Covariance matrix\n");
     /* # 121 Var(a12)\n\ */
     /* # 122 Cov(b12,a12) Var(b12)\n\ */
     /* #   ...\n\ */
     /* # 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n" */
     
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               printf("#%1d%1d%d",i,j,k);
               fprintf(ficparo,"#%1d%1d%d",i,j,k);
             }else{
               printf("%1d%1d%d",i,j,k);
               fprintf(ficparo,"%1d%1d%d",i,j,k);
               /*  printf(" %.5le",matcov[i][j]); */
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficparo," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }else{
                       if(itimes==1){
                         printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficparo," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             printf("\n");
             fprintf(ficparo,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
   } /* end of prwizard */
   /******************* Gompertz Likelihood ******************************/
   double gompertz(double x[])
   { 
     double A,B,L=0.0,sump=0.,num=0.;
     int i,n=0; /* n is the size of the sample */
   
     for (i=0;i<=imx-1 ; i++) {
       sump=sump+weight[i];
       /*    sump=sump+1;*/
       num=num+1;
     }
    
    
     /* for (i=0; i<=imx; i++) 
        if (wav[i]>0) printf("i=%d ageex=%lf agecens=%lf agedc=%lf cens=%d %d\n" ,i,ageexmed[i],agecens[i],agedc[i],cens[i],wav[i]);*/
   
     for (i=1;i<=imx ; i++)
       {
         if (cens[i] == 1 && wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agecens[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)));
         
         if (cens[i] == 0 && wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agedc[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)))
                +log(x[1]/YEARM)+x[2]*(agedc[i]-agegomp)+log(YEARM);  
         
         /*if (wav[i] > 1 && agecens[i] > 15) {*/ /* ??? */
         if (wav[i] > 1 ) { /* ??? */
           L=L+A*weight[i];
           /*      printf("\ni=%d A=%f L=%lf x[1]=%lf x[2]=%lf ageex=%lf agecens=%lf cens=%d agedc=%lf weight=%lf\n",i,A,L,x[1],x[2],ageexmed[i]*12,agecens[i]*12,cens[i],agedc[i]*12,weight[i]);*/
         }
       }
   
    /*printf("x1=%2.9f x2=%2.9f x3=%2.9f L=%f\n",x[1],x[2],x[3],L);*/
    
     return -2*L*num/sump;
   }
   
   #ifdef GSL
   /******************* Gompertz_f Likelihood ******************************/
   double gompertz_f(const gsl_vector *v, void *params)
   { 
     double A,B,LL=0.0,sump=0.,num=0.;
     double *x= (double *) v->data;
     int i,n=0; /* n is the size of the sample */
   
     for (i=0;i<=imx-1 ; i++) {
       sump=sump+weight[i];
       /*    sump=sump+1;*/
       num=num+1;
     }
    
    
     /* for (i=0; i<=imx; i++) 
        if (wav[i]>0) printf("i=%d ageex=%lf agecens=%lf agedc=%lf cens=%d %d\n" ,i,ageexmed[i],agecens[i],agedc[i],cens[i],wav[i]);*/
     printf("x[0]=%lf x[1]=%lf\n",x[0],x[1]);
     for (i=1;i<=imx ; i++)
       {
         if (cens[i] == 1 && wav[i]>1)
           A=-x[0]/(x[1])*(exp(x[1]*(agecens[i]-agegomp))-exp(x[1]*(ageexmed[i]-agegomp)));
         
         if (cens[i] == 0 && wav[i]>1)
           A=-x[0]/(x[1])*(exp(x[1]*(agedc[i]-agegomp))-exp(x[1]*(ageexmed[i]-agegomp)))
                +log(x[0]/YEARM)+x[1]*(agedc[i]-agegomp)+log(YEARM);  
         
         /*if (wav[i] > 1 && agecens[i] > 15) {*/ /* ??? */
         if (wav[i] > 1 ) { /* ??? */
           LL=LL+A*weight[i];
           /*      printf("\ni=%d A=%f L=%lf x[1]=%lf x[2]=%lf ageex=%lf agecens=%lf cens=%d agedc=%lf weight=%lf\n",i,A,L,x[1],x[2],ageexmed[i]*12,agecens[i]*12,cens[i],agedc[i]*12,weight[i]);*/
         }
       }
   
    /*printf("x1=%2.9f x2=%2.9f x3=%2.9f L=%f\n",x[1],x[2],x[3],L);*/
     printf("x[0]=%lf x[1]=%lf -2*LL*num/sump=%lf\n",x[0],x[1],-2*LL*num/sump);
    
     return -2*LL*num/sump;
   }
   #endif
   
   /******************* Printing html file ***********/
   void printinghtmlmort(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,  double p[],double **matcov,double agemortsup){
     int i,k;
   
     fprintf(fichtm,"<ul><li><h4>Result files </h4>\n Force of mortality. Parameters of the Gompertz fit (with confidence interval in brackets):<br>");
     fprintf(fichtm,"  mu(age) =%lf*exp(%lf*(age-%d)) per year<br><br>",p[1],p[2],agegomp);
     for (i=1;i<=2;i++) 
       fprintf(fichtm," p[%d] = %lf [%f ; %f]<br>\n",i,p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
     fprintf(fichtm,"<br><br><img src=\"graphmort.png\">");
     fprintf(fichtm,"</ul>");
   
   fprintf(fichtm,"<ul><li><h4>Life table</h4>\n <br>");
   
    fprintf(fichtm,"\nAge   l<inf>x</inf>     q<inf>x</inf> d(x,x+1)    L<inf>x</inf>     T<inf>x</inf>     e<infx</inf><br>");
   
    for (k=agegomp;k<(agemortsup-2);k++) 
      fprintf(fichtm,"%d %.0lf %lf %.0lf %.0lf %.0lf %lf<br>\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
    
     fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplotmort(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
   
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
     fprintf(ficgp,"set out \"graphmort.png\"\n "); 
     fprintf(ficgp,"set xlabel \"Age\"\n set ylabel \"Force of mortality (per year)\" \n "); 
     fprintf(ficgp, "set ter png small\n set log y\n"); 
     fprintf(ficgp, "set size 0.65,0.65\n");
     fprintf(ficgp,"plot [%d:100] %lf*exp(%lf*(x-%d))",agegomp,p[1],p[2],agegomp);
   
   } 
   
   int readdata(char datafile[], int firstobs, int lastobs, int *imax)
   {
   
     /*-------- data file ----------*/
     FILE *fic;
     char dummy[]="                         ";
     int i, j, n;
     int linei, month, year,iout;
     char line[MAXLINE], linetmp[MAXLINE];
     char stra[80], strb[80];
     char *stratrunc;
     int lstra;
   
   
     if((fic=fopen(datafile,"r"))==NULL)    {
       printf("Problem while opening datafile: %s\n", datafile);return 1;
       fprintf(ficlog,"Problem while opening datafile: %s\n", datafile);return 1;
     }
   
     i=1;
     linei=0;
     while ((fgets(line, MAXLINE, fic) != NULL) &&((i >= firstobs) && (i <=lastobs))) {
       linei=linei+1;
       for(j=strlen(line); j>=0;j--){  /* Untabifies line */
         if(line[j] == '\t')
           line[j] = ' ';
       }
       for(j=strlen(line)-1; (line[j]==' ')||(line[j]==10)||(line[j]==13);j--){
         ;
       };
       line[j+1]=0;  /* Trims blanks at end of line */
       if(line[0]=='#'){
         fprintf(ficlog,"Comment line\n%s\n",line);
         printf("Comment line\n%s\n",line);
         continue;
       }
       trimbb(linetmp,line); /* Trims multiple blanks in line */
       for (j=0; line[j]!='\0';j++){
         line[j]=linetmp[j];
       }
     
   
       for (j=maxwav;j>=1;j--){
         cutv(stra, strb, line, ' '); 
         if(strb[0]=='.') { /* Missing status */
           lval=-1;
         }else{
           errno=0;
           lval=strtol(strb,&endptr,10); 
         /*        if (errno == ERANGE && (lval == LONG_MAX || lval == LONG_MIN))*/
           if( strb[0]=='\0' || (*endptr != '\0')){
             printf("Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a status of wave %d. Setting maxwav=%d might be wrong.  Exiting.\n", strb, linei,i,line,j,maxwav);
             fprintf(ficlog,"Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a status of wave %d. Setting maxwav=%d might be wrong.  Exiting.\n", strb, linei,i,line,j,maxwav);fflush(ficlog);
             return 1;
           }
         }
         s[j][i]=lval;
         
         strcpy(line,stra);
         cutv(stra, strb,line,' ');
         if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
         }
         else  if(iout=sscanf(strb,"%s.") != 0){
           month=99;
           year=9999;
         }else{
           printf("Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of interview (mm/yyyy or .) at wave %d.  Exiting.\n",strb, linei,i, line,j);
           fprintf(ficlog,"Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of interview (mm/yyyy or .) at wave %d.  Exiting.\n",strb, linei,i, line,j);fflush(ficlog);
           return 1;
         }
         anint[j][i]= (double) year; 
         mint[j][i]= (double)month; 
         strcpy(line,stra);
       } /* ENd Waves */
       
       cutv(stra, strb,line,' '); 
       if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
       }
       else  if(iout=sscanf(strb,"%s.",dummy) != 0){
         month=99;
         year=9999;
       }else{
         printf("Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of death (mm/yyyy or .).  Exiting.\n",strb, linei,i,line);
           fprintf(ficlog,"Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of death (mm/yyyy or .).  Exiting.\n",strb, linei,i,line);fflush(ficlog);
           return 1;
       }
       andc[i]=(double) year; 
       moisdc[i]=(double) month; 
       strcpy(line,stra);
       
       cutv(stra, strb,line,' '); 
       if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
       }
       else  if(iout=sscanf(strb,"%s.") != 0){
         month=99;
         year=9999;
       }else{
         printf("Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of birth (mm/yyyy or .).  Exiting.\n",strb, linei,i,line);
         fprintf(ficlog,"Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of birth (mm/yyyy or .).  Exiting.\n",strb, linei,i,line);fflush(ficlog);
           return 1;
       }
       if (year==9999) {
         printf("Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of birth (mm/yyyy) but at least the year of birth should be given.  Exiting.\n",strb, linei,i,line);
         fprintf(ficlog,"Error reading data around '%s' at line number %ld for individual %d, '%s'\nShould be a date of birth (mm/yyyy) but at least the year of birth should be given. Exiting.\n",strb, linei,i,line);fflush(ficlog);
           return 1;
   
       }
       annais[i]=(double)(year);
       moisnais[i]=(double)(month); 
       strcpy(line,stra);
       
       cutv(stra, strb,line,' '); 
       errno=0;
       dval=strtod(strb,&endptr); 
       if( strb[0]=='\0' || (*endptr != '\0')){
         printf("Error reading data around '%f' at line number %ld, \"%s\" for individual %d\nShould be a weight.  Exiting.\n",dval, i,line,linei);
         fprintf(ficlog,"Error reading data around '%f' at line number %ld, \"%s\" for individual %d\nShould be a weight.  Exiting.\n",dval, i,line,linei);
         fflush(ficlog);
         return 1;
       }
       weight[i]=dval; 
       strcpy(line,stra);
       
       for (j=ncovcol;j>=1;j--){
         cutv(stra, strb,line,' '); 
         if(strb[0]=='.') { /* Missing status */
           lval=-1;
         }else{
           errno=0;
           lval=strtol(strb,&endptr,10); 
           if( strb[0]=='\0' || (*endptr != '\0')){
             printf("Error reading data around '%d' at line number %ld for individual %d, '%s'\nShould be a covariate value (=0 for the reference or 1 for alternative).  Exiting.\n",lval, linei,i, line);
             fprintf(ficlog,"Error reading data around '%d' at line number %ld for individual %d, '%s'\nShould be a covariate value (=0 for the reference or 1 for alternative).  Exiting.\n",lval, linei,i, line);fflush(ficlog);
             return 1;
           }
         }
         if(lval <-1 || lval >1){
           printf("Error reading data around '%d' at line number %ld for individual %d, '%s'\n \
    Should be a value of %d(nth) covariate (0 should be the value for the reference and 1\n \
    for the alternative. IMaCh does not build design variables automatically, do it yourself.\n \
    For example, for multinomial values like 1, 2 and 3,\n \
    build V1=0 V2=0 for the reference value (1),\n \
           V1=1 V2=0 for (2) \n \
    and V1=0 V2=1 for (3). V1=1 V2=1 should not exist and the corresponding\n \
    output of IMaCh is often meaningless.\n \
    Exiting.\n",lval,linei, i,line,j);
           fprintf(ficlog,"Error reading data around '%d' at line number %ld for individual %d, '%s'\n \
    Should be a value of %d(nth) covariate (0 should be the value for the reference and 1\n \
    for the alternative. IMaCh does not build design variables automatically, do it yourself.\n \
    For example, for multinomial values like 1, 2 and 3,\n \
    build V1=0 V2=0 for the reference value (1),\n \
           V1=1 V2=0 for (2) \n \
    and V1=0 V2=1 for (3). V1=1 V2=1 should not exist and the corresponding\n \
    output of IMaCh is often meaningless.\n \
    Exiting.\n",lval,linei, i,line,j);fflush(ficlog);
           return 1;
         }
         covar[j][i]=(double)(lval);
         strcpy(line,stra);
       }  
       lstra=strlen(stra);
        
       if(lstra > 9){ /* More than 2**32 or max of what printf can write with %ld */
         stratrunc = &(stra[lstra-9]);
         num[i]=atol(stratrunc);
       }
       else
         num[i]=atol(stra);
       /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){
         printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/
       
       i=i+1;
     } /* End loop reading  data */
   
     *imax=i-1; /* Number of individuals */
     fclose(fic);
    
     return (0);
     endread:
       printf("Exiting readdata: ");
       fclose(fic);
       return (1);
   
   
   
   }
   
   int decodemodel ( char model[], int lastobs)
   {
     int i, j, k;
     int i1, j1, k1, k2;
     char modelsav[80];
      char stra[80], strb[80], strc[80], strd[80],stre[80];
   
     if (strlen(model) >1){ /* If there is at least 1 covariate */
       j=0, j1=0, k1=1, k2=1;
       j=nbocc(model,'+'); /* j=Number of '+' */
       j1=nbocc(model,'*'); /* j1=Number of '*' */
       cptcovn=j+1; /* Number of covariates V1+V2*age+V3 =>(2 plus signs) + 1=3 
                     but the covariates which are product must be computed and stored. */
       cptcovprod=j1; /*Number of products  V1*V2 +v3*age = 2 */
       
       strcpy(modelsav,model); 
       if (strstr(model,"AGE") !=0){
         printf("Error. AGE must be in lower case 'age' model=%s ",model);
         fprintf(ficlog,"Error. AGE must be in lower case model=%s ",model);fflush(ficlog);
         return 1;
       }
       
       /* This loop fills the array Tvar from the string 'model'.*/
       /* j is the number of + signs in the model V1+V2+V3 j=2 i=3 to 1 */
       /*   modelsav=V2+V1+V4+age*V3 strb=age*V3 stra=V2+V1+V4  */
       /*  k=4 (age*V3) Tvar[k=4]= 3 (from V3) Tage[cptcovage=1]=4 */
       /*  k=3 V4 Tvar[k=3]= 4 (from V4) */
       /*  k=2 V1 Tvar[k=2]= 1 (from V1) */
       /*  k=1 Tvar[1]=2 (from V2) */
       /*  k=5 Tvar[5] */
       /* for (k=1; k<=cptcovn;k++) { */
       /*  cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]]; */
       /*  } */
       /* for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2]; */
       for(k=cptcovn; k>=1;k--){
         cutv(stra,strb,modelsav,'+'); /* keeps in strb after the first '+' 
                                        modelsav==V2+V1+V4+V3*age strb=V3*age stra=V2+V1+V4 
                                       */ 
         if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav); /* and analyzes it */
         /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/
         /*scanf("%d",i);*/
         if (strchr(strb,'*')) {  /* Model includes a product V2+V1+V4+V3*age strb=V3*age */
           cutv(strd,strc,strb,'*'); /* strd*strc  Vm*Vn: strb=V3*age strc=age strd=V3 ; V3*V2 strc=V2, strd=V3 */
           if (strcmp(strc,"age")==0) { /* Vn*age */
             cptcovprod--;
             cutv(strb,stre,strd,'V'); /* stre="V3" */
             Tvar[k]=atoi(stre);  /* V2+V1+V4+V3*age Tvar[4]=2 ; V1+V2*age Tvar[2]=2 */
             cptcovage++; /* Sums the number of covariates which include age as a product */
             Tage[cptcovage]=k;  /* Tage[1] = 4 */
             /*printf("stre=%s ", stre);*/
           } else if (strcmp(strd,"age")==0) { /* or age*Vn */
             cptcovprod--;
             cutv(strb,stre,strc,'V');
             Tvar[k]=atoi(stre);
             cptcovage++;
             Tage[cptcovage]=k;
           } else {  /* Age is not in the model product V2+V1+V1*V4+V3*age+V3*V2  strb=V3*V2*/
             /* loops on k1=1 (V3*V2) and k1=2 V4*V3 */
             cutv(strb,stre,strc,'V'); /* strc= Vn, stre is n; strb=V3*V2 stre=3 strc=*/
             Tvar[k]=ncovcol+k1;  /* For model-covariate k tells which data-covariate to use but
                                     because this model-covariate is a construction we invent a new column
                                     ncovcol + k1
                                     If already ncovcol=4 and model=V2+V1+V1*V4+age*V3+V3*V2
                                     Tvar[3=V1*V4]=4+1 Tvar[5=V3*V2]=4 + 2= 6, etc */
             cutv(strb,strc,strd,'V'); /* strd was Vm, strc is m */
             Tprod[k1]=k;  /* Tprod[1]=3(=V1*V4) for V2+V1+V1*V4+age*V3+V3*V2  */
             Tvard[k1][1]=atoi(strc); /* m 1 for V1*/
             Tvard[k1][2]=atoi(stre); /* n 4 for V4*/
             Tvar[cptcovn+k2]=Tvard[k1][1]; /* Tvar[(cptcovn=4+k2=1)=5]= 1 (V1) */
             Tvar[cptcovn+k2+1]=Tvard[k1][2];  /* Tvar[(cptcovn=4+(k2=1)+1)=6]= 4 (V4) */
             for (i=1; i<=lastobs;i++){
               /* Computes the new covariate which is a product of
                  covar[n][i]* covar[m][i] and stores it at ncovol+k1 */
               covar[ncovcol+k1][i]=covar[atoi(stre)][i]*covar[atoi(strc)][i];
             }
             k1++;
             k2=k2+2;
           } /* End age is not in the model */
         } /* End if model includes a product */
         else { /* no more sum */
           /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/
          /*  scanf("%d",i);*/
           cutv(strd,strc,strb,'V');
           Tvar[k]=atoi(strc);
         }
         strcpy(modelsav,stra);  /* modelsav=V2+V1+V4 stra=V2+V1+V4 */ 
         /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);
           scanf("%d",i);*/
       } /* end of loop + */
     } /* end model */
     
     /*The number n of Vn is stored in Tvar. cptcovage =number of age covariate. Tage gives the position of age. cptcovprod= number of products.
       If model=V1+V1*age then Tvar[1]=1 Tvar[2]=1 cptcovage=1 Tage[1]=2 cptcovprod=0*/
   
     /* printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);
     printf("cptcovprod=%d ", cptcovprod);
     fprintf(ficlog,"cptcovprod=%d ", cptcovprod);
   
     scanf("%d ",i);*/
   
   
     return (0); /* with covar[new additional covariate if product] and Tage if age */ 
     endread:
       printf("Exiting decodemodel: ");
       return (1);
   }
   
   calandcheckages(int imx, int maxwav, double *agemin, double *agemax, int *nberr, int *nbwarn )
   {
     int i, m;
   
     for (i=1; i<=imx; i++) {
       for(m=2; (m<= maxwav); m++) {
         if (((int)mint[m][i]== 99) && (s[m][i] <= nlstate)){
           anint[m][i]=9999;
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]==9999 && s[m][i]>nlstate){
           *nberr++;
           printf("Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           fprintf(ficlog,"Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]!=9999 && s[m][i]>nlstate){
           *nberr++;
           printf("Error! Month of death of individual %ld on line %d was unknown %2d, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,(int)moisdc[i]); 
           fprintf(ficlog,"Error! Month of death of individual %ld on line %d was unknown %f, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,moisdc[i]); 
           s[m][i]=-1; /* We prefer to skip it (and to skip it in version 0.8a1 too */
         }
       }
     }
   
     for (i=1; i<=imx; i++)  {
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);
       for(m=firstpass; (m<= lastpass); m++){
         if(s[m][i] >0 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5){
           if (s[m][i] >= nlstate+1) {
             if(agedc[i]>0)
               if((int)moisdc[i]!=99 && (int)andc[i]!=9999)
                 agev[m][i]=agedc[i];
             /*if(moisdc[i]==99 && andc[i]==9999) s[m][i]=-1;*/
               else {
                 if ((int)andc[i]!=9999){
                   nbwarn++;
                   printf("Warning negative age at death: %ld line:%d\n",num[i],i);
                   fprintf(ficlog,"Warning negative age at death: %ld line:%d\n",num[i],i);
                   agev[m][i]=-1;
                 }
               }
           }
           else if(s[m][i] !=9){ /* Standard case, age in fractional
                                    years but with the precision of a month */
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);
             if((int)mint[m][i]==99 || (int)anint[m][i]==9999)
               agev[m][i]=1;
             else if(agev[m][i] < *agemin){ 
               *agemin=agev[m][i];
               printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], *agemin);
             }
             else if(agev[m][i] >*agemax){
               *agemax=agev[m][i];
               /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/
             }
             /*agev[m][i]=anint[m][i]-annais[i];*/
             /*     agev[m][i] = age[i]+2*m;*/
           }
           else { /* =9 */
             agev[m][i]=1;
             s[m][i]=-1;
           }
         }
         else /*= 0 Unknown */
           agev[m][i]=1;
       }
       
     }
     for (i=1; i<=imx; i++)  {
       for(m=firstpass; (m<=lastpass); m++){
         if (s[m][i] > (nlstate+ndeath)) {
           *nberr++;
           printf("Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           fprintf(ficlog,"Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           return 1;
         }
       }
     }
   
     /*for (i=1; i<=imx; i++){
     for (m=firstpass; (m<lastpass); m++){
        printf("%ld %d %.lf %d %d\n", num[i],(covar[1][i]),agev[m][i],s[m][i],s[m+1][i]);
   }
   
   }*/
   
   
     printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);
     fprintf(ficlog,"Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax); 
   
     return (0);
     endread:
       printf("Exiting calandcheckages: ");
       return (1);
   }
   
   
   /***********************************************/
   /**************** Main Program *****************/
   /***********************************************/
   
   int main(int argc, char *argv[])
   {
   #ifdef GSL
     const gsl_multimin_fminimizer_type *T;
     size_t iteri = 0, it;
     int rval = GSL_CONTINUE;
     int status = GSL_SUCCESS;
     double ssval;
   #endif
     int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav);
     int i,j, k, n=MAXN,iter,m,size=100,cptcode, cptcod;
     int linei, month, year,iout;
     int jj, ll, li, lj, lk, imk;
     int numlinepar=0; /* Current linenumber of parameter file */
     int itimes;
     int NDIM=2;
     int vpopbased=0;
   
     char ca[32], cb[32], cc[32];
     /*  FILE *fichtm; *//* Html File */
     /* FILE *ficgp;*/ /*Gnuplot File */
     struct stat info;
     double agedeb, agefin,hf;
     double ageminpar=1.e20,agemin=1.e20, agemaxpar=-1.e20, agemax=-1.e20;
   
     double fret;
     double **xi,tmp,delta;
   
     double dum; /* Dummy variable */
     double ***p3mat;
     double ***mobaverage;
     int *indx;
     char line[MAXLINE], linepar[MAXLINE];
     char path[MAXLINE],pathc[MAXLINE],pathcd[MAXLINE],pathtot[MAXLINE],model[MAXLINE];
     char pathr[MAXLINE], pathimach[MAXLINE]; 
     char **bp, *tok, *val; /* pathtot */
     int firstobs=1, lastobs=10;
     int sdeb, sfin; /* Status at beginning and end */
     int c,  h , cpt,l;
     int ju,jl, mi;
     int i1,j1, jk,aa,bb, stepsize, ij;
     int jnais,jdc,jint4,jint1,jint2,jint3,*tab; 
     int mobilavproj=0 , prevfcast=0 ; /* moving average of prev, If prevfcast=1 prevalence projection */
     int mobilav=0,popforecast=0;
     int hstepm, nhstepm;
     int agemortsup;
     float  sumlpop=0.;
     double jprev1=1, mprev1=1,anprev1=2000,jprev2=1, mprev2=1,anprev2=2000;
     double jpyram=1, mpyram=1,anpyram=2000,jpyram1=1, mpyram1=1,anpyram1=2000;
   
     double bage, fage, age, agelim, agebase;
     double ftolpl=FTOL;
     double **prlim;
     double ***param; /* Matrix of parameters */
     double  *p;
     double **matcov; /* Matrix of covariance */
     double ***delti3; /* Scale */
     double *delti; /* Scale */
     double ***eij, ***vareij;
     double **varpl; /* Variances of prevalence limits by age */
     double *epj, vepp;
     double kk1, kk2;
     double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000;
     double **ximort;
     char *alph[]={"a","a","b","c","d","e"}, str[4];
     int *dcwave;
   
     char z[1]="c", occ;
   
     /*char  *strt;*/
     char strtend[80];
   
     long total_usecs;
    
   /*   setlocale (LC_ALL, ""); */
   /*   bindtextdomain (PACKAGE, LOCALEDIR); */
   /*   textdomain (PACKAGE); */
   /*   setlocale (LC_CTYPE, ""); */
   /*   setlocale (LC_MESSAGES, ""); */
   
     /*   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */
     (void) gettimeofday(&start_time,&tzp);
     curr_time=start_time;
     tm = *localtime(&start_time.tv_sec);
     tmg = *gmtime(&start_time.tv_sec);
     strcpy(strstart,asctime(&tm));
   
   /*  printf("Localtime (at start)=%s",strstart); */
   /*  tp.tv_sec = tp.tv_sec +86400; */
   /*  tm = *localtime(&start_time.tv_sec); */
   /*   tmg.tm_year=tmg.tm_year +dsign*dyear; */
   /*   tmg.tm_mon=tmg.tm_mon +dsign*dmonth; */
   /*   tmg.tm_hour=tmg.tm_hour + 1; */
   /*   tp.tv_sec = mktime(&tmg); */
   /*   strt=asctime(&tmg); */
   /*   printf("Time(after) =%s",strstart);  */
   /*  (void) time (&time_value);
   *  printf("time=%d,t-=%d\n",time_value,time_value-86400);
   *  tm = *localtime(&time_value);
   *  strstart=asctime(&tm);
   *  printf("tim_value=%d,asctime=%s\n",time_value,strstart); 
   */
   
     nberr=0; /* Number of errors and warnings */
     nbwarn=0;
     getcwd(pathcd, size);
   
     printf("\n%s\n%s",version,fullversion);
     if(argc <=1){
       printf("\nEnter the parameter file name: ");
       fgets(pathr,FILENAMELENGTH,stdin);
       i=strlen(pathr);
       if(pathr[i-1]=='\n')
         pathr[i-1]='\0';
      for (tok = pathr; tok != NULL; ){
         printf("Pathr |%s|\n",pathr);
         while ((val = strsep(&tok, "\"" )) != NULL && *val == '\0');
         printf("val= |%s| pathr=%s\n",val,pathr);
         strcpy (pathtot, val);
         if(pathr[0] == '\0') break; /* Dirty */
       }
     }
     else{
       strcpy(pathtot,argv[1]);
     }
     /*if(getcwd(pathcd, MAXLINE)!= NULL)printf ("Error pathcd\n");*/
     /*cygwin_split_path(pathtot,path,optionfile);
       printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/
     /* cutv(path,optionfile,pathtot,'\\');*/
   
     /* Split argv[0], imach program to get pathimach */
     printf("\nargv[0]=%s argv[1]=%s, \n",argv[0],argv[1]);
     split(argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
     printf("\nargv[0]=%s pathimach=%s, \noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
    /*   strcpy(pathimach,argv[0]); */
     /* Split argv[1]=pathtot, parameter file name to get path, optionfile, extension and name */
     split(pathtot,path,optionfile,optionfilext,optionfilefiname);
     printf("\npathtot=%s,\npath=%s,\noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
     chdir(path); /* Can be a relative path */
     if(getcwd(pathcd,MAXLINE) > 0) /* So pathcd is the full path */
       printf("Current directory %s!\n",pathcd);
     strcpy(command,"mkdir ");
     strcat(command,optionfilefiname);
     if((outcmd=system(command)) != 0){
       printf("Problem creating directory or it already exists %s%s, err=%d\n",path,optionfilefiname,outcmd);
       /* fprintf(ficlog,"Problem creating directory %s%s\n",path,optionfilefiname); */
       /* fclose(ficlog); */
   /*     exit(1); */
     }
   /*   if((imk=mkdir(optionfilefiname))<0){ */
   /*     perror("mkdir"); */
   /*   } */
   
     /*-------- arguments in the command line --------*/
   
     /* Log file */
     strcat(filelog, optionfilefiname);
     strcat(filelog,".log");    /* */
     if((ficlog=fopen(filelog,"w"))==NULL)    {
       printf("Problem with logfile %s\n",filelog);
       goto end;
     }
     fprintf(ficlog,"Log filename:%s\n",filelog);
     fprintf(ficlog,"\n%s\n%s",version,fullversion);
     fprintf(ficlog,"\nEnter the parameter file name: \n");
     fprintf(ficlog,"pathimach=%s\npathtot=%s\n\
    path=%s \n\
    optionfile=%s\n\
    optionfilext=%s\n\
    optionfilefiname=%s\n",pathimach,pathtot,path,optionfile,optionfilext,optionfilefiname);
   
     printf("Local time (at start):%s",strstart);
     fprintf(ficlog,"Local time (at start): %s",strstart);
     fflush(ficlog);
   /*   (void) gettimeofday(&curr_time,&tzp); */
   /*   printf("Elapsed time %d\n", asc_diff_time(curr_time.tv_sec-start_time.tv_sec,tmpout)); */
   
     /* */
     strcpy(fileres,"r");
     strcat(fileres, optionfilefiname);
     strcat(fileres,".txt");    /* Other files have txt extension */
   
     /*---------arguments file --------*/
   
     if((ficpar=fopen(optionfile,"r"))==NULL)    {
       printf("Problem with optionfile %s\n",optionfile);
       fprintf(ficlog,"Problem with optionfile %s\n",optionfile);
       fflush(ficlog);
       goto end;
     }
   
   
   
     strcpy(filereso,"o");
     strcat(filereso,fileres);
     if((ficparo=fopen(filereso,"w"))==NULL) { /* opened on subdirectory */
       printf("Problem with Output resultfile: %s\n", filereso);
       fprintf(ficlog,"Problem with Output resultfile: %s\n", filereso);
       fflush(ficlog);
       goto end;
     }
   
     /* Reads comments: lines beginning with '#' */
     numlinepar=0;
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d model=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncovcol, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);
     numlinepar++;
     printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate,ndeath, maxwav, mle, weightopt,model);
     fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fprintf(ficlog,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fflush(ficlog);
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
      
     covar=matrix(0,NCOVMAX,1,n); 
     cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement plus one, indepently of n in Vn*/
     /* v1+v2+v3+v2*v4+v5*age makes cptcovn = 5
        v1+v2*age+v2*v3 makes cptcovn = 3
     */
     if (strlen(model)>1) 
       cptcovn=nbocc(model,'+')+1;
     /* ncovprod */
     ncovmodel=2+cptcovn; /*Number of variables including intercept and age = cptcovn + intercept + age : v1+v2+v3+v2*v4+v5*age makes 5+2=7*/
     nvar=ncovmodel-1; /* Suppressing age as a basic covariate */
     nforce= (nlstate+ndeath-1)*nlstate; /* Number of forces ij from state i to j */
     npar= nforce*ncovmodel; /* Number of parameters like aij*/
     if(npar >MAXPARM || nlstate >NLSTATEMAX || ndeath >NDEATHMAX || ncovmodel>NCOVMAX){
       printf("Too complex model for current IMaCh: npar=(nlstate+ndeath-1)*nlstate*ncovmodel=%d >= %d(MAXPARM) or nlstate=%d >= %d(NLSTATEMAX) or ndeath=%d >= %d(NDEATHMAX) or ncovmodel=(k+age+#of+signs)=%d(NCOVMAX) >= %d\n",npar, MAXPARM, nlstate, NLSTATEMAX, ndeath, NDEATHMAX, ncovmodel, NCOVMAX);
       fprintf(ficlog,"Too complex model for current IMaCh: %d >=%d(MAXPARM) or %d >=%d(NLSTATEMAX) or %d >=%d(NDEATHMAX) or %d(NCOVMAX) >=%d\n",npar, MAXPARM, nlstate, NLSTATEMAX, ndeath, NDEATHMAX, ncovmodel, NCOVMAX);
       fflush(stdout);
       fclose (ficlog);
       goto end;
     }
     delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     delti=delti3[1][1];
     /*delti=vector(1,npar); *//* Scale of each paramater (output from hesscov)*/
     if(mle==-1){ /* Print a wizard for help writing covariance matrix */
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       fclose (ficparo);
       fclose (ficlog);
       goto end;
       exit(0);
     }
     else if(mle==-3) {
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       matcov=matrix(1,npar,1,npar);
     }
     else{
       /* Read guess parameters */
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
       
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       for(i=1; i <=nlstate; i++){
         j=0;
         for(jj=1; jj <=nlstate+ndeath; jj++){
           if(jj==i) continue;
           j++;
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1 != i) && (j1 != j)){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n \
   It might be a problem of design; if ncovcol and the model are correct\n \
   run imach with mle=-1 to get a correct template of the parameter file.\n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           fprintf(ficparo,"%1d%1d",i1,j1);
           if(mle==1)
             printf("%1d%1d",i,j);
           fprintf(ficlog,"%1d%1d",i,j);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar," %lf",&param[i][j][k]);
             if(mle==1){
               printf(" %lf",param[i][j][k]);
               fprintf(ficlog," %lf",param[i][j][k]);
             }
             else
               fprintf(ficlog," %lf",param[i][j][k]);
             fprintf(ficparo," %lf",param[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           if(mle==1)
             printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficparo,"\n");
         }
       }  
       fflush(ficlog);
   
       p=param[1][1];
       
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
   
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath-1; j++){
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1-i)*(j1-j)!=0){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           printf("%1d%1d",i,j);
           fprintf(ficparo,"%1d%1d",i1,j1);
           fprintf(ficlog,"%1d%1d",i1,j1);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar,"%le",&delti3[i][j][k]);
             printf(" %le",delti3[i][j][k]);
             fprintf(ficparo," %le",delti3[i][j][k]);
             fprintf(ficlog," %le",delti3[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           printf("\n");
           fprintf(ficparo,"\n");
           fprintf(ficlog,"\n");
         }
       }
       fflush(ficlog);
   
       delti=delti3[1][1];
   
   
       /* free_ma3x(delti3,1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ /* Hasn't to to freed here otherwise delti is no more allocated */
     
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
     
       matcov=matrix(1,npar,1,npar);
       for(i=1; i <=npar; i++)
         for(j=1; j <=npar; j++) matcov[i][j]=0.;
         
       for(i=1; i <=npar; i++){
         fscanf(ficpar,"%s",&str);
         if(mle==1)
           printf("%s",str);
         fprintf(ficlog,"%s",str);
         fprintf(ficparo,"%s",str);
         for(j=1; j <=i; j++){
           fscanf(ficpar," %le",&matcov[i][j]);
           if(mle==1){
             printf(" %.5le",matcov[i][j]);
           }
           fprintf(ficlog," %.5le",matcov[i][j]);
           fprintf(ficparo," %.5le",matcov[i][j]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         if(mle==1)
           printf("\n");
         fprintf(ficlog,"\n");
         fprintf(ficparo,"\n");
       }
       for(i=1; i <=npar; i++)
         for(j=i+1;j<=npar;j++)
           matcov[i][j]=matcov[j][i];
       
       if(mle==1)
         printf("\n");
       fprintf(ficlog,"\n");
       
       fflush(ficlog);
       
       /*-------- Rewriting parameter file ----------*/
       strcpy(rfileres,"r");    /* "Rparameterfile */
       strcat(rfileres,optionfilefiname);    /* Parameter file first name*/
       strcat(rfileres,".");    /* */
       strcat(rfileres,optionfilext);    /* Other files have txt extension */
       if((ficres =fopen(rfileres,"w"))==NULL) {
         printf("Problem writing new parameter file: %s\n", fileres);goto end;
         fprintf(ficlog,"Problem writing new parameter file: %s\n", fileres);goto end;
       }
       fprintf(ficres,"#%s\n",version);
     }    /* End of mle != -3 */
   
   
     n= lastobs;
     num=lvector(1,n);
     moisnais=vector(1,n);
     annais=vector(1,n);
     moisdc=vector(1,n);
     andc=vector(1,n);
     agedc=vector(1,n);
     cod=ivector(1,n);
     weight=vector(1,n);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */
     mint=matrix(1,maxwav,1,n);
     anint=matrix(1,maxwav,1,n);
     s=imatrix(1,maxwav+1,1,n); /* s[i][j] health state for wave i and individual j */ 
     tab=ivector(1,NCOVMAX);
     ncodemax=ivector(1,8); /* hard coded ? */
   
     /* Reads data from file datafile */
     if (readdata(datafile, firstobs, lastobs, &imx)==1)
       goto end;
   
     /* Calculation of the number of parameters from char model */
       /*    modelsav=V2+V1+V4+age*V3 strb=age*V3 stra=V2+V1+V4 
           k=4 (age*V3) Tvar[k=4]= 3 (from V3) Tag[cptcovage=1]=4
           k=3 V4 Tvar[k=3]= 4 (from V4)
           k=2 V1 Tvar[k=2]= 1 (from V1)
           k=1 Tvar[1]=2 (from V2)
       */
     Tvar=ivector(1,NCOVMAX); /* Was 15 changed to NCOVMAX. */
     /*  V2+V1+V4+age*V3 is a model with 4 covariates (3 plus signs). 
         For each model-covariate stores the data-covariate id. Tvar[1]=2, Tvar[2]=1, Tvar[3]=4, 
         Tvar[4=age*V3] is 3 and 'age' is recorded in Tage.
     */
     /* For model-covariate k tells which data-covariate to use but
       because this model-covariate is a construction we invent a new column
       ncovcol + k1
       If already ncovcol=4 and model=V2+V1+V1*V4+age*V3
       Tvar[3=V1*V4]=4+1 etc */
     Tprod=ivector(1,15); 
     /* Tprod[k1=1]=3(=V1*V4) for V2+V1+V1*V4+age*V3
        if  V2+V1+V1*V4+age*V3+V3*V2   TProd[k1=2]=5 (V3*V2)
     */
     Tvaraff=ivector(1,15); 
     Tvard=imatrix(1,15,1,2); /* For V3*V2 Tvard[k1=2][1]=3 (V3) Tvard[k1=2][2]=2(V2) */
     Tage=ivector(1,15); /* Gives the covariate id of covariates associated with age: V2 + V1 + age*V4 + V3*age
                            4 covariates (3 plus signs)
                            Tage[1=V3*age]= 4; Tage[2=age*V4] = 3
                         */  
   
     if(decodemodel(model, lastobs) == 1)
       goto end;
   
     if((double)(lastobs-imx)/(double)imx > 1.10){
       nbwarn++;
       printf("Warning: The value of parameter lastobs=%d is big compared to the \n  effective number of cases imx=%d, please adjust, \n  otherwise you are allocating more memory than necessary.\n",lastobs, imx); 
       fprintf(ficlog,"Warning: The value of parameter lastobs=%d is big compared to the \n  effective number of cases imx=%d, please adjust, \n  otherwise you are allocating more memory than necessary.\n",lastobs, imx); 
     }
       /*  if(mle==1){*/
     if (weightopt != 1) { /* Maximisation without weights. We can have weights different from 1 but want no weight*/
       for(i=1;i<=imx;i++) weight[i]=1.0; /* changed to imx */
     }
   
       /*-calculation of age at interview from date of interview and age at death -*/
     agev=matrix(1,maxwav,1,imx);
   
     if(calandcheckages(imx, maxwav, &agemin, &agemax, &nberr, &nbwarn) == 1)
       goto end;
   
   
     agegomp=(int)agemin;
     free_vector(moisnais,1,n);
     free_vector(annais,1,n);
     /* free_matrix(mint,1,maxwav,1,n);
        free_matrix(anint,1,maxwav,1,n);*/
     free_vector(moisdc,1,n);
     free_vector(andc,1,n);
   
      
     wav=ivector(1,imx);
     dh=imatrix(1,lastpass-firstpass+1,1,imx);
     bh=imatrix(1,lastpass-firstpass+1,1,imx);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);
      
     /* Concatenates waves */
     concatwav(wav, dh, bh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);
   
     /* Routine tricode is to calculate cptcoveff (real number of unique covariates) and to associate covariable number and modality */
   
     nbcode=imatrix(0,NCOVMAX,0,NCOVMAX); 
     ncodemax[1]=1;
     if (cptcovn > 0) tricode(Tvar,nbcode,imx);
         
     codtab=imatrix(1,100,1,10); /* Cross tabulation to get the order of 
                                    the estimations*/
     h=0;
     m=pow(2,cptcoveff);
    
     for(k=1;k<=cptcoveff; k++){ /* scans any effective covariate */
       for(i=1; i <=(m/pow(2,k));i++){ /* i=1 to 8/1=8; i=1 to 8/2=4; i=1 to 8/8=1 */ 
         for(j=1; j <= ncodemax[k]; j++){ /* For each modality of this covariate */
           for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){  /* cpt=1 to 8/2**(3+1-1 or 3+1-3) =1 or 4 */ 
             h++;
             if (h>m) {
               h=1;
               codtab[h][k]=j;
               codtab[h][Tvar[k]]=j;
             }
             printf("h=%d k=%d j=%d codtab[h][k]=%d Tvar[k]=%d codtab[h][Tvar[k]]=%d \n",h, k,j,codtab[h][k],Tvar[k],codtab[h][Tvar[k]]);
           } 
         }
       }
     } 
     /* printf("codtab[1][2]=%d codtab[2][2]=%d",codtab[1][2],codtab[2][2]); 
        codtab[1][2]=1;codtab[2][2]=2; */
     /* for(i=1; i <=m ;i++){ 
        for(k=1; k <=cptcovn; k++){
          printf("i=%d k=%d %d %d ",i,k,codtab[i][k], cptcoveff);
        }
        printf("\n");
        }
        scanf("%d",i);*/
       
     /*------------ gnuplot -------------*/
     strcpy(optionfilegnuplot,optionfilefiname);
     if(mle==-3)
       strcat(optionfilegnuplot,"-mort");
     strcat(optionfilegnuplot,".gp");
   
     if((ficgp=fopen(optionfilegnuplot,"w"))==NULL) {
       printf("Problem with file %s",optionfilegnuplot);
     }
     else{
       fprintf(ficgp,"\n# %s\n", version); 
       fprintf(ficgp,"# %s\n", optionfilegnuplot); 
       fprintf(ficgp,"set missing 'NaNq'\n");
     }
     /*  fclose(ficgp);*/
     /*--------- index.htm --------*/
   
     strcpy(optionfilehtm,optionfilefiname); /* Main html file */
     if(mle==-3)
       strcat(optionfilehtm,"-mort");
     strcat(optionfilehtm,".htm");
     if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtm);
       exit(0);
     }
   
     strcpy(optionfilehtmcov,optionfilefiname); /* Only for matrix of covariance */
     strcat(optionfilehtmcov,"-cov.htm");
     if((fichtmcov=fopen(optionfilehtmcov,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtmcov), exit(0);
     }
     else{
     fprintf(fichtmcov,"<html><head>\n<title>IMaCh Cov %s</title></head>\n <body><font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n",\
             optionfilehtmcov,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model);
     }
   
     fprintf(fichtm,"<html><head>\n<title>IMaCh %s</title></head>\n <body><font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n\
   \n\
   <hr  size=\"2\" color=\"#EC5E5E\">\
    <ul><li><h4>Parameter files</h4>\n\
    - Parameter file: <a href=\"%s.%s\">%s.%s</a><br>\n\
    - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>\n\
    - Log file of the run: <a href=\"%s\">%s</a><br>\n\
    - Gnuplot file name: <a href=\"%s\">%s</a><br>\n\
    - Date and time at start: %s</ul>\n",\
             optionfilehtm,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model,\
             optionfilefiname,optionfilext,optionfilefiname,optionfilext,\
             fileres,fileres,\
             filelog,filelog,optionfilegnuplot,optionfilegnuplot,strstart);
     fflush(fichtm);
   
     strcpy(pathr,path);
     strcat(pathr,optionfilefiname);
     chdir(optionfilefiname); /* Move to directory named optionfile */
     
     /* Calculates basic frequencies. Computes observed prevalence at single age
        and prints on file fileres'p'. */
     freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart);
   
     fprintf(fichtm,"\n");
     fprintf(fichtm,"<br>Total number of observations=%d <br>\n\
   Youngest age at first (selected) pass %.2f, oldest age %.2f<br>\n\
   Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>\n",\
             imx,agemin,agemax,jmin,jmax,jmean);
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */
       
      
     /* For Powell, parameters are in a vector p[] starting at p[1]
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */
   
     globpr=0; /* To get the number ipmx of contributions and the sum of weights*/
   
     if (mle==-3){
       ximort=matrix(1,NDIM,1,NDIM); 
   /*     ximort=gsl_matrix_alloc(1,NDIM,1,NDIM); */
       cens=ivector(1,n);
       ageexmed=vector(1,n);
       agecens=vector(1,n);
       dcwave=ivector(1,n);
    
       for (i=1; i<=imx; i++){
         dcwave[i]=-1;
         for (m=firstpass; m<=lastpass; m++)
           if (s[m][i]>nlstate) {
             dcwave[i]=m;
             /*    printf("i=%d j=%d s=%d dcwave=%d\n",i,j, s[j][i],dcwave[i]);*/
             break;
           }
       }
   
       for (i=1; i<=imx; i++) {
         if (wav[i]>0){
           ageexmed[i]=agev[mw[1][i]][i];
           j=wav[i];
           agecens[i]=1.; 
   
           if (ageexmed[i]> 1 && wav[i] > 0){
             agecens[i]=agev[mw[j][i]][i];
             cens[i]= 1;
           }else if (ageexmed[i]< 1) 
             cens[i]= -1;
           if (agedc[i]< AGESUP && agedc[i]>1 && dcwave[i]>firstpass && dcwave[i]<=lastpass)
             cens[i]=0 ;
         }
         else cens[i]=-1;
       }
       
       for (i=1;i<=NDIM;i++) {
         for (j=1;j<=NDIM;j++)
           ximort[i][j]=(i == j ? 1.0 : 0.0);
       }
       
       p[1]=0.0268; p[NDIM]=0.083;
       /*printf("%lf %lf", p[1], p[2]);*/
       
       
   #ifdef GSL
       printf("GSL optimization\n");  fprintf(ficlog,"Powell\n");
   #elsedef
       printf("Powell\n");  fprintf(ficlog,"Powell\n");
   #endif
       strcpy(filerespow,"pow-mort"); 
       strcat(filerespow,fileres);
       if((ficrespow=fopen(filerespow,"w"))==NULL) {
         printf("Problem with resultfile: %s\n", filerespow);
         fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
       }
   #ifdef GSL
       fprintf(ficrespow,"# GSL optimization\n# iter -2*LL");
   #elsedef
       fprintf(ficrespow,"# Powell\n# iter -2*LL");
   #endif
       /*  for (i=1;i<=nlstate;i++)
           for(j=1;j<=nlstate+ndeath;j++)
           if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
       */
       fprintf(ficrespow,"\n");
   #ifdef GSL
       /* gsl starts here */ 
       T = gsl_multimin_fminimizer_nmsimplex;
       gsl_multimin_fminimizer *sfm = NULL;
       gsl_vector *ss, *x;
       gsl_multimin_function minex_func;
   
       /* Initial vertex size vector */
       ss = gsl_vector_alloc (NDIM);
       
       if (ss == NULL){
         GSL_ERROR_VAL ("failed to allocate space for ss", GSL_ENOMEM, 0);
       }
       /* Set all step sizes to 1 */
       gsl_vector_set_all (ss, 0.001);
   
       /* Starting point */
       
       x = gsl_vector_alloc (NDIM);
       
       if (x == NULL){
         gsl_vector_free(ss);
         GSL_ERROR_VAL ("failed to allocate space for x", GSL_ENOMEM, 0);
       }
     
       /* Initialize method and iterate */
       /*     p[1]=0.0268; p[NDIM]=0.083; */
   /*     gsl_vector_set(x, 0, 0.0268); */
   /*     gsl_vector_set(x, 1, 0.083); */
       gsl_vector_set(x, 0, p[1]);
       gsl_vector_set(x, 1, p[2]);
   
       minex_func.f = &gompertz_f;
       minex_func.n = NDIM;
       minex_func.params = (void *)&p; /* ??? */
       
       sfm = gsl_multimin_fminimizer_alloc (T, NDIM);
       gsl_multimin_fminimizer_set (sfm, &minex_func, x, ss);
       
       printf("Iterations beginning .....\n\n");
       printf("Iter. #    Intercept       Slope     -Log Likelihood     Simplex size\n");
   
       iteri=0;
       while (rval == GSL_CONTINUE){
         iteri++;
         status = gsl_multimin_fminimizer_iterate(sfm);
         
         if (status) printf("error: %s\n", gsl_strerror (status));
         fflush(0);
         
         if (status) 
           break;
         
         rval = gsl_multimin_test_size (gsl_multimin_fminimizer_size (sfm), 1e-6);
         ssval = gsl_multimin_fminimizer_size (sfm);
         
         if (rval == GSL_SUCCESS)
           printf ("converged to a local maximum at\n");
         
         printf("%5d ", iteri);
         for (it = 0; it < NDIM; it++){
           printf ("%10.5f ", gsl_vector_get (sfm->x, it));
         }
         printf("f() = %-10.5f ssize = %.7f\n", sfm->fval, ssval);
       }
       
       printf("\n\n Please note: Program should be run many times with varying starting points to detemine global maximum\n\n");
       
       gsl_vector_free(x); /* initial values */
       gsl_vector_free(ss); /* inital step size */
       for (it=0; it<NDIM; it++){
         p[it+1]=gsl_vector_get(sfm->x,it);
         fprintf(ficrespow," %.12lf", p[it]);
       }
       gsl_multimin_fminimizer_free (sfm); /* p *(sfm.x.data) et p *(sfm.x.data+1)  */
   #endif
   #ifdef POWELL
        powell(p,ximort,NDIM,ftol,&iter,&fret,gompertz);
   #endif  
       fclose(ficrespow);
       
       hesscov(matcov, p, NDIM, delti, 1e-4, gompertz); 
   
       for(i=1; i <=NDIM; i++)
         for(j=i+1;j<=NDIM;j++)
           matcov[i][j]=matcov[j][i];
       
       printf("\nCovariance matrix\n ");
       for(i=1; i <=NDIM; i++) {
         for(j=1;j<=NDIM;j++){ 
           printf("%f ",matcov[i][j]);
         }
         printf("\n ");
       }
       
       printf("iter=%d MLE=%f Eq=%lf*exp(%lf*(age-%d))\n",iter,-gompertz(p),p[1],p[2],agegomp);
       for (i=1;i<=NDIM;i++) 
         printf("%f [%f ; %f]\n",p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
   
       lsurv=vector(1,AGESUP);
       lpop=vector(1,AGESUP);
       tpop=vector(1,AGESUP);
       lsurv[agegomp]=100000;
       
       for (k=agegomp;k<=AGESUP;k++) {
         agemortsup=k;
         if (p[1]*exp(p[2]*(k-agegomp))>1) break;
       }
       
       for (k=agegomp;k<agemortsup;k++)
         lsurv[k+1]=lsurv[k]-lsurv[k]*(p[1]*exp(p[2]*(k-agegomp)));
       
       for (k=agegomp;k<agemortsup;k++){
         lpop[k]=(lsurv[k]+lsurv[k+1])/2.;
         sumlpop=sumlpop+lpop[k];
       }
       
       tpop[agegomp]=sumlpop;
       for (k=agegomp;k<(agemortsup-3);k++){
         /*  tpop[k+1]=2;*/
         tpop[k+1]=tpop[k]-lpop[k];
       }
       
       
       printf("\nAge   lx     qx    dx    Lx     Tx     e(x)\n");
       for (k=agegomp;k<(agemortsup-2);k++) 
         printf("%d %.0lf %lf %.0lf %.0lf %.0lf %lf\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
       
       
       replace_back_to_slash(pathc,pathcd); /* Even gnuplot wants a / */
       printinggnuplotmort(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtmlmort(fileres,title,datafile, firstpass, lastpass, \
                        stepm, weightopt,\
                        model,imx,p,matcov,agemortsup);
       
       free_vector(lsurv,1,AGESUP);
       free_vector(lpop,1,AGESUP);
       free_vector(tpop,1,AGESUP);
   #ifdef GSL
       free_ivector(cens,1,n);
       free_vector(agecens,1,n);
       free_ivector(dcwave,1,n);
       free_matrix(ximort,1,NDIM,1,NDIM);
   #endif
     } /* Endof if mle==-3 */
     
     else{ /* For mle >=1 */
       globpr=0;/* debug */
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("First Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       globpr=1; /* to print the contributions */
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("Second Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       if(mle>=1){ /* Could be 1 or 2 */
         mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);
       }
       
       /*--------- results files --------------*/
       fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle= 0 weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate, ndeath, maxwav, weightopt,model);
       
       
       fprintf(ficres,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       fprintf(ficlog,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(k=1; k <=(nlstate+ndeath); k++){
           if (k != i) {
             printf("%d%d ",i,k);
             fprintf(ficlog,"%d%d ",i,k);
             fprintf(ficres,"%1d%1d ",i,k);
             for(j=1; j <=ncovmodel; j++){
               printf("%lf ",p[jk]);
               fprintf(ficlog,"%lf ",p[jk]);
               fprintf(ficres,"%lf ",p[jk]);
               jk++; 
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       if(mle!=0){
         /* Computing hessian and covariance matrix */
         ftolhess=ftol; /* Usually correct */
         hesscov(matcov, p, npar, delti, ftolhess, func);
       }
       fprintf(ficres,"# Scales (for hessian or gradient estimation)\n");
       printf("# Scales (for hessian or gradient estimation)\n");
       fprintf(ficlog,"# Scales (for hessian or gradient estimation)\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if (j!=i) {
             fprintf(ficres,"%1d%1d",i,j);
             printf("%1d%1d",i,j);
             fprintf(ficlog,"%1d%1d",i,j);
             for(k=1; k<=ncovmodel;k++){
               printf(" %.5e",delti[jk]);
               fprintf(ficlog," %.5e",delti[jk]);
               fprintf(ficres," %.5e",delti[jk]);
               jk++;
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       
       fprintf(ficres,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       if(mle>=1)
         printf("# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       fprintf(ficlog,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       /* # 121 Var(a12)\n\ */
       /* # 122 Cov(b12,a12) Var(b12)\n\ */
       /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
       /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
       /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
       /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
       /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
       /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
       
       
       /* Just to have a covariance matrix which will be more understandable
          even is we still don't want to manage dictionary of variables
       */
       for(itimes=1;itimes<=2;itimes++){
         jj=0;
         for(i=1; i <=nlstate; i++){
           for(j=1; j <=nlstate+ndeath; j++){
             if(j==i) continue;
             for(k=1; k<=ncovmodel;k++){
               jj++;
               ca[0]= k+'a'-1;ca[1]='\0';
               if(itimes==1){
                 if(mle>=1)
                   printf("#%1d%1d%d",i,j,k);
                 fprintf(ficlog,"#%1d%1d%d",i,j,k);
                 fprintf(ficres,"#%1d%1d%d",i,j,k);
               }else{
                 if(mle>=1)
                   printf("%1d%1d%d",i,j,k);
                 fprintf(ficlog,"%1d%1d%d",i,j,k);
                 fprintf(ficres,"%1d%1d%d",i,j,k);
               }
               ll=0;
               for(li=1;li <=nlstate; li++){
                 for(lj=1;lj <=nlstate+ndeath; lj++){
                   if(lj==li) continue;
                   for(lk=1;lk<=ncovmodel;lk++){
                     ll++;
                     if(ll<=jj){
                       cb[0]= lk +'a'-1;cb[1]='\0';
                       if(ll<jj){
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficlog," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficres," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }else{
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficlog," Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficres," Var(%s%1d%1d)",ca,i,j);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }
                     }
                   } /* end lk */
                 } /* end lj */
               } /* end li */
               if(mle>=1)
                 printf("\n");
               fprintf(ficlog,"\n");
               fprintf(ficres,"\n");
               numlinepar++;
             } /* end k*/
           } /*end j */
         } /* end i */
       } /* end itimes */
       
       fflush(ficlog);
       fflush(ficres);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       estepm=0;
       fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf estepm=%d\n",&ageminpar,&agemaxpar, &bage, &fage, &estepm);
       if (estepm==0 || estepm < stepm) estepm=stepm;
       if (fage <= 2) {
         bage = ageminpar;
         fage = agemaxpar;
       }
       
       fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");
       fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"begin-prev-date=%lf/%lf/%lf end-prev-date=%lf/%lf/%lf mov_average=%d\n",&jprev1, &mprev1,&anprev1,&jprev2, &mprev2,&anprev2,&mobilav);
       fprintf(ficparo,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficres,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       printf("begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficlog,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       
       dateprev1=anprev1+(mprev1-1)/12.+(jprev1-1)/365.;
       dateprev2=anprev2+(mprev2-1)/12.+(jprev2-1)/365.;
       
       fscanf(ficpar,"pop_based=%d\n",&popbased);
       fprintf(ficparo,"pop_based=%d\n",popbased);   
       fprintf(ficres,"pop_based=%d\n",popbased);   
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"prevforecast=%d starting-proj-date=%lf/%lf/%lf final-proj-date=%lf/%lf/%lf mobil_average=%d\n",&prevfcast,&jproj1,&mproj1,&anproj1,&jproj2,&mproj2,&anproj2,&mobilavproj);
       fprintf(ficparo,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       printf("prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficlog,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficres,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       /* day and month of proj2 are not used but only year anproj2.*/
       
       
       
       /*  freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);*/
       /*,dateprev1,dateprev2,jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
       
       replace_back_to_slash(pathc,pathcd); /* Even gnuplot wants a / */
       printinggnuplot(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtml(fileres,title,datafile, firstpass, lastpass, stepm, weightopt,\
                    model,imx,jmin,jmax,jmean,rfileres,popforecast,estepm,\
                    jprev1,mprev1,anprev1,jprev2,mprev2,anprev2);
         
      /*------------ free_vector  -------------*/
      /*  chdir(path); */
    
       free_ivector(wav,1,imx);
       free_imatrix(dh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(bh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
       free_lvector(num,1,n);
       free_vector(agedc,1,n);
       /*free_matrix(covar,0,NCOVMAX,1,n);*/
       /*free_matrix(covar,1,NCOVMAX,1,n);*/
       fclose(ficparo);
       fclose(ficres);
   
   
       /*--------------- Prevalence limit  (period or stable prevalence) --------------*/
     
       strcpy(filerespl,"pl");
       strcat(filerespl,fileres);
       if((ficrespl=fopen(filerespl,"w"))==NULL) {
         printf("Problem with period (stable) prevalence resultfile: %s\n", filerespl);goto end;
         fprintf(ficlog,"Problem with period (stable) prevalence resultfile: %s\n", filerespl);goto end;
       }
       printf("Computing period (stable) prevalence: result on file '%s' \n", filerespl);
       fprintf(ficlog,"Computing period (stable) prevalence: result on file '%s' \n", filerespl);
       pstamp(ficrespl);
       fprintf(ficrespl,"# Period (stable) prevalence \n");
       fprintf(ficrespl,"#Age ");
       for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);
       fprintf(ficrespl,"\n");
     
       prlim=matrix(1,nlstate,1,nlstate);
   
       agebase=ageminpar;
       agelim=agemaxpar;
       ftolpl=1.e-10;
       i1=cptcoveff;
       if (cptcovn < 1){i1=1;}
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           /* to clean */
           printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,codtab[cptcod][cptcov],nbcode);
           fprintf(ficrespl,"\n#******");
           printf("\n#******");
           fprintf(ficlog,"\n#******");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             printf(" V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficlog," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficrespl,"******\n");
           printf("******\n");
           fprintf(ficlog,"******\n");
           
           for (age=agebase; age<=agelim; age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             fprintf(ficrespl,"%.0f ",age );
             for(j=1;j<=cptcoveff;j++)
               fprintf(ficrespl,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             for(i=1; i<=nlstate;i++)
               fprintf(ficrespl," %.5f", prlim[i][i]);
             fprintf(ficrespl,"\n");
           }
         }
       }
       fclose(ficrespl);
   
       /*------------- h Pij x at various ages ------------*/
     
       strcpy(filerespij,"pij");  strcat(filerespij,fileres);
       if((ficrespij=fopen(filerespij,"w"))==NULL) {
         printf("Problem with Pij resultfile: %s\n", filerespij);goto end;
         fprintf(ficlog,"Problem with Pij resultfile: %s\n", filerespij);goto end;
       }
       printf("Computing pij: result on file '%s' \n", filerespij);
       fprintf(ficlog,"Computing pij: result on file '%s' \n", filerespij);
     
       stepsize=(int) (stepm+YEARM-1)/YEARM;
       /*if (stepm<=24) stepsize=2;*/
   
       agelim=AGESUP;
       hstepm=stepsize*YEARM; /* Every year of age */
       hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */ 
   
       /* hstepm=1;   aff par mois*/
       pstamp(ficrespij);
       fprintf(ficrespij,"#****** h Pij x Probability to be in state j at age x+h being in i at x ");
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficrespij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrespij,"******\n");
           
           for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
             nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
   
             /*      nhstepm=nhstepm*YEARM; aff par mois*/
   
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             fprintf(ficrespij,"# Cov Agex agex+h hpijx with i,j=");
             for(i=1; i<=nlstate;i++)
               for(j=1; j<=nlstate+ndeath;j++)
                 fprintf(ficrespij," %1d-%1d",i,j);
             fprintf(ficrespij,"\n");
             for (h=0; h<=nhstepm; h++){
               fprintf(ficrespij,"%d %3.f %3.f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );
               for(i=1; i<=nlstate;i++)
                 for(j=1; j<=nlstate+ndeath;j++)
                   fprintf(ficrespij," %.5f", p3mat[i][j][h]);
               fprintf(ficrespij,"\n");
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             fprintf(ficrespij,"\n");
           }
         }
       }
   
       varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax,strstart);
   
       fclose(ficrespij);
   
       probs= ma3x(1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
       for(i=1;i<=AGESUP;i++)
         for(j=1;j<=NCOVMAX;j++)
           for(k=1;k<=NCOVMAX;k++)
             probs[i][j][k]=0.;
   
       /*---------- Forecasting ------------------*/
       /*if((stepm == 1) && (strcmp(model,".")==0)){*/
       if(prevfcast==1){
         /*    if(stepm ==1){*/
         prevforecast(fileres, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff);
         /* (popforecast==1) populforecast(fileres, anpyram,mpyram,jpyram, agemin,agemax, dateprev1, dateprev2,mobilav, agedeb, fage, popforecast, popfile, anpyram1,p, i1);*/
         /*      }  */
         /*      else{ */
         /*        erreur=108; */
         /*        printf("Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*        fprintf(ficlog,"Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*      } */
       }
     
   
       /* Computes prevalence between agemin (i.e minimal age computed) and no more ageminpar */
   
       prevalence(probs, agemin, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
       /*  printf("ageminpar=%f, agemax=%f, s[lastpass][imx]=%d, agev[lastpass][imx]=%f, nlstate=%d, imx=%d,  mint[lastpass][imx]=%f, anint[lastpass][imx]=%f,dateprev1=%f, dateprev2=%f, firstpass=%d, lastpass=%d\n",\
           ageminpar, agemax, s[lastpass][imx], agev[lastpass][imx], nlstate, imx, mint[lastpass][imx],anint[lastpass][imx], dateprev1, dateprev2, firstpass, lastpass);
       */
   
       if (mobilav!=0) {
         mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
         if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
           fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
           printf(" Error in movingaverage mobilav=%d\n",mobilav);
         }
       }
   
   
       /*---------- Health expectancies, no variances ------------*/
   
       strcpy(filerese,"e");
       strcat(filerese,fileres);
       if((ficreseij=fopen(filerese,"w"))==NULL) {
         printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
         fprintf(ficlog,"Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
       }
       printf("Computing Health Expectancies: result on file '%s' \n", filerese);
       fprintf(ficlog,"Computing Health Expectancies: result on file '%s' \n", filerese);
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1; 
           fprintf(ficreseij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficreseij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficreseij,"******\n");
   
           eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           evsij(eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, strstart);  
         
           free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
         }
       }
       fclose(ficreseij);
   
   
       /*---------- Health expectancies and variances ------------*/
   
   
       strcpy(filerest,"t");
       strcat(filerest,fileres);
       if((ficrest=fopen(filerest,"w"))==NULL) {
         printf("Problem with total LE resultfile: %s\n", filerest);goto end;
         fprintf(ficlog,"Problem with total LE resultfile: %s\n", filerest);goto end;
       }
       printf("Computing Total Life expectancies with their standard errors: file '%s' \n", filerest); 
       fprintf(ficlog,"Computing Total Life expectancies with their standard errors: file '%s' \n", filerest); 
   
   
       strcpy(fileresstde,"stde");
       strcat(fileresstde,fileres);
       if((ficresstdeij=fopen(fileresstde,"w"))==NULL) {
         printf("Problem with Health Exp. and std errors resultfile: %s\n", fileresstde); exit(0);
         fprintf(ficlog,"Problem with Health Exp. and std errors resultfile: %s\n", fileresstde); exit(0);
       }
       printf("Computing Health Expectancies and standard errors: result on file '%s' \n", fileresstde);
       fprintf(ficlog,"Computing Health Expectancies and standard errors: result on file '%s' \n", fileresstde);
   
       strcpy(filerescve,"cve");
       strcat(filerescve,fileres);
       if((ficrescveij=fopen(filerescve,"w"))==NULL) {
         printf("Problem with Covar. Health Exp. resultfile: %s\n", filerescve); exit(0);
         fprintf(ficlog,"Problem with Covar. Health Exp. resultfile: %s\n", filerescve); exit(0);
       }
       printf("Computing Covar. of Health Expectancies: result on file '%s' \n", filerescve);
       fprintf(ficlog,"Computing Covar. of Health Expectancies: result on file '%s' \n", filerescve);
   
       strcpy(fileresv,"v");
       strcat(fileresv,fileres);
       if((ficresvij=fopen(fileresv,"w"))==NULL) {
         printf("Problem with variance resultfile: %s\n", fileresv);exit(0);
         fprintf(ficlog,"Problem with variance resultfile: %s\n", fileresv);exit(0);
       }
       printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
       fprintf(ficlog,"Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1; 
           fprintf(ficrest,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrest,"******\n");
   
           fprintf(ficresstdeij,"\n#****** ");
           fprintf(ficrescveij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficresstdeij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficrescveij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficresstdeij,"******\n");
           fprintf(ficrescveij,"******\n");
   
           fprintf(ficresvij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvij,"******\n");
   
           eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           cvevsij(eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, delti, matcov, strstart);  
    
           vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           pstamp(ficrest);
           for(vpopbased=0; vpopbased <= popbased; vpopbased++){ /* Done for vpopbased=0 and vpopbased=1 if popbased==1*/
             oldm=oldms;savm=savms;
             varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,vpopbased,mobilav, strstart);   fprintf(ficrest,"# Total life expectancy with std error and decomposition into time to be expected in each health state\n#  (weighted average of eij where weights are ");
             if(vpopbased==1)
               fprintf(ficrest,"the age specific prevalence observed (cross-sectionally) in the population i.e cross-sectionally\n in each health state (popbased=1) (mobilav=%d)\n",mobilav);
             else
               fprintf(ficrest,"the age specific period (stable) prevalences in each health state \n");
             fprintf(ficrest,"# Age e.. (std) ");
             for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);
             fprintf(ficrest,"\n");
   
             epj=vector(1,nlstate+1);
             for(age=bage; age <=fage ;age++){
               prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
               if (vpopbased==1) {
                 if(mobilav ==0){
                   for(i=1; i<=nlstate;i++)
                     prlim[i][i]=probs[(int)age][i][k];
                 }else{ /* mobilav */ 
                   for(i=1; i<=nlstate;i++)
                     prlim[i][i]=mobaverage[(int)age][i][k];
                 }
               }
           
               fprintf(ficrest," %4.0f",age);
               for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){
                 for(i=1, epj[j]=0.;i <=nlstate;i++) {
                   epj[j] += prlim[i][i]*eij[i][j][(int)age];
                   /*  printf("%lf %lf ", prlim[i][i] ,eij[i][j][(int)age]);*/
                 }
                 epj[nlstate+1] +=epj[j];
               }
   
               for(i=1, vepp=0.;i <=nlstate;i++)
                 for(j=1;j <=nlstate;j++)
                   vepp += vareij[i][j][(int)age];
               fprintf(ficrest," %7.3f (%7.3f)", epj[nlstate+1],sqrt(vepp));
               for(j=1;j <=nlstate;j++){
                 fprintf(ficrest," %7.3f (%7.3f)", epj[j],sqrt(vareij[j][j][(int)age]));
               }
               fprintf(ficrest,"\n");
             }
           }
           free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_vector(epj,1,nlstate+1);
         }
       }
       free_vector(weight,1,n);
       free_imatrix(Tvard,1,15,1,2);
       free_imatrix(s,1,maxwav+1,1,n);
       free_matrix(anint,1,maxwav,1,n); 
       free_matrix(mint,1,maxwav,1,n);
       free_ivector(cod,1,n);
       free_ivector(tab,1,NCOVMAX);
       fclose(ficresstdeij);
       fclose(ficrescveij);
       fclose(ficresvij);
       fclose(ficrest);
       fclose(ficpar);
     
       /*------- Variance of period (stable) prevalence------*/   
   
       strcpy(fileresvpl,"vpl");
       strcat(fileresvpl,fileres);
       if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {
         printf("Problem with variance of period (stable) prevalence  resultfile: %s\n", fileresvpl);
         exit(0);
       }
       printf("Computing Variance-covariance of period (stable) prevalence: file '%s' \n", fileresvpl);
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficresvpl,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvpl,"******\n");
         
           varpl=matrix(1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k,strstart);
           free_matrix(varpl,1,nlstate,(int) bage, (int)fage);
         }
       }
   
       fclose(ficresvpl);
   
       /*---------- End : free ----------------*/
       if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       free_ma3x(probs,1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     }  /* mle==-3 arrives here for freeing */
    endfree:
     free_matrix(prlim,1,nlstate,1,nlstate);
       free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(covar,0,NCOVMAX,1,n);
       free_matrix(matcov,1,npar,1,npar);
       /*free_vector(delti,1,npar);*/
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       free_matrix(agev,1,maxwav,1,imx);
       free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);
   
       free_ivector(ncodemax,1,8);
       free_ivector(Tvar,1,15);
       free_ivector(Tprod,1,15);
       free_ivector(Tvaraff,1,15);
       free_ivector(Tage,1,15);
   
       free_imatrix(nbcode,0,NCOVMAX,0,NCOVMAX);
       free_imatrix(codtab,1,100,1,10);
     fflush(fichtm);
     fflush(ficgp);
     
   
     if((nberr >0) || (nbwarn>0)){
       printf("End of Imach with %d errors and/or %d warnings\n",nberr,nbwarn);
       fprintf(ficlog,"End of Imach with %d errors and/or warnings %d\n",nberr,nbwarn);
     }else{
       printf("End of Imach\n");
       fprintf(ficlog,"End of Imach\n");
     }
     printf("See log file on %s\n",filelog);
     /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */
     (void) gettimeofday(&end_time,&tzp);
     tm = *localtime(&end_time.tv_sec);
     tmg = *gmtime(&end_time.tv_sec);
     strcpy(strtend,asctime(&tm));
     printf("Local time at start %s\nLocal time at end   %s",strstart, strtend); 
     fprintf(ficlog,"Local time at start %s\nLocal time at end   %s\n",strstart, strtend); 
     printf("Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
   
     printf("Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     fprintf(ficlog,"Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
     fprintf(ficlog,"Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     /*  printf("Total time was %d uSec.\n", total_usecs);*/
   /*   if(fileappend(fichtm,optionfilehtm)){ */
     fprintf(fichtm,"<br>Local time at start %s<br>Local time at end   %s<br>\n</body></html>",strstart, strtend);
     fclose(fichtm);
     fprintf(fichtmcov,"<br>Local time at start %s<br>Local time at end   %s<br>\n</body></html>",strstart, strtend);
     fclose(fichtmcov);
     fclose(ficgp);
     fclose(ficlog);
     /*------ End -----------*/
   
   
      printf("Before Current directory %s!\n",pathcd);
      if(chdir(pathcd) != 0)
       printf("Can't move to directory %s!\n",path);
     if(getcwd(pathcd,MAXLINE) > 0)
       printf("Current directory %s!\n",pathcd);
     /*strcat(plotcmd,CHARSEPARATOR);*/
     sprintf(plotcmd,"gnuplot");
   #ifndef UNIX
     sprintf(plotcmd,"\"%sgnuplot.exe\"",pathimach);
   #endif
     if(!stat(plotcmd,&info)){
       printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
       if(!stat(getenv("GNUPLOTBIN"),&info)){
         printf("Error gnuplot program not found: %s Environment GNUPLOTBIN not set.\n",plotcmd);fflush(stdout);
       }else
         strcpy(pplotcmd,plotcmd);
   #ifdef UNIX
       strcpy(plotcmd,GNUPLOTPROGRAM);
       if(!stat(plotcmd,&info)){
         printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
       }else
         strcpy(pplotcmd,plotcmd);
   #endif
     }else
       strcpy(pplotcmd,plotcmd);
     
     sprintf(plotcmd,"%s %s",pplotcmd, optionfilegnuplot);
     printf("Starting graphs with: %s\n",plotcmd);fflush(stdout);
   
     if((outcmd=system(plotcmd)) != 0){
       printf("\n Problem with gnuplot\n");
     }
     printf(" Wait...");
     while (z[0] != 'q') {
       /* chdir(path); */
       printf("\nType e to edit output files, g to graph again and q for exiting: ");
       scanf("%s",z);
   /*     if (z[0] == 'c') system("./imach"); */
       if (z[0] == 'e') {
         printf("Starting browser with: %s",optionfilehtm);fflush(stdout);
         system(optionfilehtm);
       }
       else if (z[0] == 'g') system(plotcmd);
       else if (z[0] == 'q') exit(0);
     }
     end:
     while (z[0] != 'q') {
       printf("\nType  q for exiting: ");
       scanf("%s",z);
     }
   }
   
   
   

Removed from v.1.7  
changed lines
  Added in v.1.138


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