--- imach/src/imach.c 2017/04/26 16:22:11 1.265 +++ imach/src/imach.c 2017/06/27 10:17:50 1.271 @@ -1,6 +1,24 @@ -/* $Id: imach.c,v 1.265 2017/04/26 16:22:11 brouard Exp $ +/* $Id: imach.c,v 1.271 2017/06/27 10:17:50 brouard Exp $ $State: Exp $ $Log: imach.c,v $ + Revision 1.271 2017/06/27 10:17:50 brouard + Summary: Some bug with rint + + Revision 1.270 2017/05/24 05:45:29 brouard + *** empty log message *** + + Revision 1.269 2017/05/23 08:39:25 brouard + Summary: Code into subroutine, cleanings + + Revision 1.268 2017/05/18 20:09:32 brouard + Summary: backprojection and confidence intervals of backprevalence + + Revision 1.267 2017/05/13 10:25:05 brouard + Summary: temporary save for backprojection + + Revision 1.266 2017/05/13 07:26:12 brouard + Summary: Version 0.99r13 (improvements and bugs fixed) + Revision 1.265 2017/04/26 16:22:11 brouard Summary: imach 0.99r13 Some bugs fixed @@ -815,7 +833,7 @@ Back prevalence and projections: p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); oldm=oldms;savm=savms; - - hbxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k); + - hbxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k, nres); Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' months (i.e. until age (in years) age+nhstepm*hstepm*stepm/12) by multiplying @@ -983,6 +1001,7 @@ typedef struct { #define YEARM 12. /**< Number of months per year */ /* #define AGESUP 130 */ #define AGESUP 150 +#define AGEINF 0 #define AGEMARGE 25 /* Marge for agemin and agemax for(iage=agemin-AGEMARGE; iage <= agemax+3+AGEMARGE; iage++) */ #define AGEBASE 40 #define AGEOVERFLOW 1.e20 @@ -997,12 +1016,12 @@ typedef struct { #define ODIRSEPARATOR '\\' #endif -/* $Id: imach.c,v 1.265 2017/04/26 16:22:11 brouard Exp $ */ +/* $Id: imach.c,v 1.271 2017/06/27 10:17:50 brouard Exp $ */ /* $State: Exp $ */ #include "version.h" char version[]=__IMACH_VERSION__; char copyright[]="February 2016,INED-EUROREVES-Institut de longevite-Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research 25293121), Intel Software 2015-2018"; -char fullversion[]="$Revision: 1.265 $ $Date: 2017/04/26 16:22:11 $"; +char fullversion[]="$Revision: 1.271 $ $Date: 2017/06/27 10:17:50 $"; char strstart[80]; char optionfilext[10], optionfilefiname[FILENAMELENGTH]; int erreur=0, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings */ @@ -1074,8 +1093,7 @@ FILE *ficrescveij; char filerescve[FILENAMELENGTH]; FILE *ficresvij; char fileresv[FILENAMELENGTH]; -FILE *ficresvpl; -char fileresvpl[FILENAMELENGTH]; + char title[MAXLINE]; char model[MAXLINE]; /**< The model line */ char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH], filerespl[FILENAMELENGTH], fileresplb[FILENAMELENGTH]; @@ -1173,8 +1191,8 @@ double *agedc; double **covar; /**< covar[j,i], value of jth covariate for individual i, * covar=matrix(0,NCOVMAX,1,n); * cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*age; */ -double **coqvar; /* Fixed quantitative covariate iqv */ -double ***cotvar; /* Time varying covariate itv */ +double **coqvar; /* Fixed quantitative covariate nqv */ +double ***cotvar; /* Time varying covariate ntv */ double ***cotqvar; /* Time varying quantitative covariate itqv */ double idx; int **nbcode, *Tvar; /**< model=V2 => Tvar[1]= 2 */ @@ -2657,12 +2675,12 @@ Earliest age to start was %d-%d=%d, ncvl max=vector(1,nlstate); meandiff=vector(1,nlstate); - dnewm=ddnewms; doldm=ddoldms; dsavm=ddsavms; - oldm=oldms; savm=savms; - - /* Starting with matrix unity */ - for (ii=1;ii<=nlstate+ndeath;ii++) - for (j=1;j<=nlstate+ndeath;j++){ + dnewm=ddnewms; doldm=ddoldms; dsavm=ddsavms; + oldm=oldms; savm=savms; + + /* Starting with matrix unity */ + for (ii=1;ii<=nlstate+ndeath;ii++) + for (j=1;j<=nlstate+ndeath;j++){ oldm[ii][j]=(ii==j ? 1.0 : 0.0); } @@ -2736,8 +2754,27 @@ Earliest age to start was %d-%d=%d, ncvl /* out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, bmij(pmmij,cov,ncovmodel,x,nlstate,prevacurrent, ageminpar, agemaxpar, dnewm, doldm, dsavm,ij)); /\* Bug Valgrind *\/ */ /* out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, bmij(pmmij,cov,ncovmodel,x,nlstate,prevacurrent, dnewm, doldm, dsavm,ij)); /\* Bug Valgrind *\/ */ out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, bmij(pmmij,cov,ncovmodel,x,nlstate,prevacurrent,ij)); /* Bug Valgrind */ + /* if((int)age == 86 || (int)age == 87){ */ + /* printf(" Backward prevalim age=%d agefin=%d \n", (int) age, (int) agefin); */ + /* for(i=1; i<=nlstate+ndeath; i++) { */ + /* printf("%d newm= ",i); */ + /* for(j=1;j<=nlstate+ndeath;j++) { */ + /* printf("%f ",newm[i][j]); */ + /* } */ + /* printf("oldm * "); */ + /* for(j=1;j<=nlstate+ndeath;j++) { */ + /* printf("%f ",oldm[i][j]); */ + /* } */ + /* printf(" bmmij "); */ + /* for(j=1;j<=nlstate+ndeath;j++) { */ + /* printf("%f ",pmmij[i][j]); */ + /* } */ + /* printf("\n"); */ + /* } */ + /* } */ savm=oldm; oldm=newm; + for(j=1; j<=nlstate; j++){ max[j]=0.; min[j]=1.; @@ -2756,9 +2793,9 @@ Earliest age to start was %d-%d=%d, ncvl meandiff[i]=(max[i]-min[i])/(max[i]+min[i])*2.; /* mean difference for each column */ maxmax=FMAX(maxmax,meandiff[i]); /* printf("Back age= %d meandiff[%d]=%f, agefin=%d max[%d]=%f min[%d]=%f maxmax=%f\n", (int)age, i, meandiff[i],(int)agefin, i, max[i], i, min[i],maxmax); */ - } /* j loop */ + } /* i loop */ *ncvyear= -( (int)age- (int)agefin); - /* printf("Back maxmax=%lf ncvloop=%d, age=%d, agefin=%d ncvyear=%d \n", maxmax, ncvloop, (int)age, (int)agefin, *ncvyear);*/ + /* printf("Back maxmax=%lf ncvloop=%d, age=%d, agefin=%d ncvyear=%d \n", maxmax, ncvloop, (int)age, (int)agefin, *ncvyear); */ if(maxmax < ftolpl){ /* printf("OK Back maxmax=%lf ncvloop=%d, age=%d, agefin=%d ncvyear=%d \n", maxmax, ncvloop, (int)age, (int)agefin, *ncvyear); */ free_vector(min,1,nlstate); @@ -2788,7 +2825,7 @@ Oldest age to start was %d-%d=%d, ncvloo double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate ) { /* According to parameters values stored in x and the covariate's values stored in cov, - computes the probability to be observed in state j being in state i by appying the + computes the probability to be observed in state j (after stepm years) being in state i by appying the model to the ncovmodel covariates (including constant and age). lnpijopii=ln(pij/pii)= aij+bij*age+cij*v1+dij*v2+... = sum_nc=1^ncovmodel xij(nc)*cov[nc] and, according on how parameters are entered, the position of the coefficient xij(nc) of the @@ -2797,8 +2834,9 @@ double **pmij(double **ps, double *cov, j>=i nc + ((i-1)*(nlstate+ndeath-1)+(j-2))*ncovmodel Computes ln(pij/pii) (lnpijopii), deduces pij/pii by exponentiation, sums on j different of i to get 1-pii/pii, deduces pii, and then all pij. - Outputs ps[i][j] the probability to be observed in j being in j according to + Outputs ps[i][j] or probability to be observed in j being in i according to the values of the covariates cov[nc] and corresponding parameter values x[nc+shiftij] + Sum on j ps[i][j] should equal to 1. */ double s1, lnpijopii; /*double t34;*/ @@ -2862,7 +2900,7 @@ double **pmij(double **ps, double *cov, /* for(i=1; i<= npar; i++) printf("%f ",x[i]); goto end;*/ - return ps; + return ps; /* Pointer is unchanged since its call */ } /*************** backward transition probabilities ***************/ @@ -2871,15 +2909,15 @@ double **pmij(double **ps, double *cov, /* double **bmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate, double ***prevacurrent, double ***dnewm, double **doldm, double **dsavm, int ij ) */ double **bmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate, double ***prevacurrent, int ij ) { - /* Computes the backward probability at age agefin and covariate ij - * and returns in **ps as well as **bmij. + /* Computes the backward probability at age agefin and covariate combination ij. In fact cov is already filled and x too. + * Call to pmij(cov and x), call to cross prevalence, sums and inverses, left multiply, and returns in **ps as well as **bmij. */ int i, ii, j,k; double **out, **pmij(); double sumnew=0.; double agefin; - + double k3=0.; /* constant of the w_x diagonal matrixe (in order for B to sum to 1 even for death state) */ double **dnewm, **dsavm, **doldm; double **bbmij; @@ -2888,44 +2926,68 @@ double **pmij(double **ps, double *cov, dsavm=ddsavms; agefin=cov[2]; + /* Bx = Diag(w_x) P_x Diag(Sum_i w^i_x p^ij_x */ /* bmij *//* age is cov[2], ij is included in cov, but we need for - the observed prevalence (with this covariate ij) */ - dsavm=pmij(pmmij,cov,ncovmodel,x,nlstate); - /* We do have the matrix Px in savm and we need pij */ + the observed prevalence (with this covariate ij) at beginning of transition */ + /* dsavm=pmij(pmmij,cov,ncovmodel,x,nlstate); */ + + /* P_x */ + pmmij=pmij(pmmij,cov,ncovmodel,x,nlstate); /*This is forward probability from agefin to agefin + stepm */ + /* outputs pmmij which is a stochastic matrix in row */ + + /* Diag(w_x) */ + /* Problem with prevacurrent which can be zero */ + sumnew=0.; + /*for (ii=1;ii<=nlstate+ndeath;ii++){*/ + for (ii=1;ii<=nlstate;ii++){ /* Only on live states */ + /* printf(" agefin=%d, ii=%d, ij=%d, prev=%f\n",(int)agefin,ii, ij, prevacurrent[(int)agefin][ii][ij]); */ + sumnew+=prevacurrent[(int)agefin][ii][ij]; + } + if(sumnew >0.01){ /* At least some value in the prevalence */ + for (ii=1;ii<=nlstate+ndeath;ii++){ + for (j=1;j<=nlstate+ndeath;j++) + doldm[ii][j]=(ii==j ? prevacurrent[(int)agefin][ii][ij]/sumnew : 0.0); + } + }else{ + for (ii=1;ii<=nlstate+ndeath;ii++){ + for (j=1;j<=nlstate+ndeath;j++) + doldm[ii][j]=(ii==j ? 1./nlstate : 0.0); + } + /* if(sumnew <0.9){ */ + /* printf("Problem internal bmij B: sum on i wi <0.9: j=%d, sum_i wi=%lf,agefin=%d\n",j,sumnew, (int)agefin); */ + /* } */ + } + k3=0.0; /* We put the last diagonal to 0 */ + for (ii=nlstate+1;ii<=nlstate+ndeath;ii++){ + doldm[ii][ii]= k3; + } + /* End doldm, At the end doldm is diag[(w_i)] */ + + /* left Product of this diag matrix by pmmij=Px (dnewm=dsavm*doldm) */ + bbmij=matprod2(dnewm, doldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, pmmij); /* Bug Valgrind */ + + /* Diag(Sum_i w^i_x p^ij_x */ + /* w1 p11 + w2 p21 only on live states N1./N..*N11/N1. + N2./N..*N21/N2.=(N11+N21)/N..=N.1/N.. */ for (j=1;j<=nlstate+ndeath;j++){ - sumnew=0.; /* w1 p11 + w2 p21 only on live states */ + sumnew=0.; for (ii=1;ii<=nlstate;ii++){ - sumnew+=dsavm[ii][j]*prevacurrent[(int)agefin][ii][ij]; + /* sumnew+=dsavm[ii][j]*prevacurrent[(int)agefin][ii][ij]; */ + sumnew+=pmmij[ii][j]*doldm[ii][ii]; /* Yes prevalence at beginning of transition */ } /* sumnew is (N11+N21)/N..= N.1/N.. = sum on i of w_i pij */ for (ii=1;ii<=nlstate+ndeath;ii++){ - if(sumnew >= 1.e-10){ /* if(agefin >= agemaxpar && agefin <= agemaxpar+stepm/YEARM){ */ - /* doldm[ii][j]=(ii==j ? 1./sumnew : 0.0); */ + /* dsavm[ii][j]=(ii==j ? 1./sumnew : 0.0); */ /* }else if(agefin >= agemaxpar+stepm/YEARM){ */ - /* doldm[ii][j]=(ii==j ? 1./sumnew : 0.0); */ + /* dsavm[ii][j]=(ii==j ? 1./sumnew : 0.0); */ /* }else */ - doldm[ii][j]=(ii==j ? 1./sumnew : 0.0); - }else{ - ; - /* printf("ii=%d, i=%d, doldm=%lf dsavm=%lf, probs=%lf, sumnew=%lf,agefin=%d\n",ii,j,doldm[ii][j],dsavm[ii][j],prevacurrent[(int)agefin][ii][ij],sumnew, (int)agefin); */ - } + dsavm[ii][j]=(ii==j ? 1./sumnew : 0.0); } /*End ii */ - } /* End j, At the end doldm is diag[1/(w_1p1i+w_2 p2i)] */ - /* left Product of this diag matrix by dsavm=Px (newm=dsavm*doldm) */ - bbmij=matprod2(dnewm, dsavm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, doldm); /* Bug Valgrind */ - /* dsavm=doldm; /\* dsavm is now diag [1/(w_1p1i+w_2 p2i)] but can be overwritten*\/ */ - /* doldm=dnewm; /\* doldm is now Px * diag [1/(w_1p1i+w_2 p2i)] *\/ */ - /* dnewm=dsavm; /\* doldm is now Px * diag [1/(w_1p1i+w_2 p2i)] *\/ */ - /* left Product of this matrix by diag matrix of prevalences (savm) */ - for (j=1;j<=nlstate+ndeath;j++){ - for (ii=1;ii<=nlstate+ndeath;ii++){ - dsavm[ii][j]=(ii==j ? prevacurrent[(int)agefin][ii][ij] : 0.0); - } - } /* End j, At the end oldm is diag[1/(w_1p1i+w_2 p2i)] */ - ps=matprod2(doldm, dsavm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, dnewm); /* Bug Valgrind */ - /* newm or out is now diag[w_i] * Px * diag [1/(w_1p1i+w_2 p2i)] */ + } /* End j, At the end dsavm is diag[1/(w_1p1i+w_2 p2i)] for ALL states even if the sum is only for live states */ + + ps=matprod2(ps, dnewm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, dsavm); /* Bug Valgrind */ + /* ps is now diag[w_i] * Px * diag [1/(w_1p1i+w_2 p2i)] */ /* end bmij */ - return ps; + return ps; /*pointer is unchanged */ } /*************** transition probabilities ***************/ @@ -3138,20 +3200,20 @@ double ***hpxij(double ***po, int nhstep } for(i=1; i<=nlstate+ndeath; i++) for(j=1;j<=nlstate+ndeath;j++) { - po[i][j][h]=newm[i][j]; - /*if(h==nhstepm) printf("po[%d][%d][%d]=%f ",i,j,h,po[i][j][h]);*/ + po[i][j][h]=newm[i][j]; + /*if(h==nhstepm) printf("po[%d][%d][%d]=%f ",i,j,h,po[i][j][h]);*/ } /*printf("h=%d ",h);*/ } /* end h */ - /* printf("\n H=%d \n",h); */ + /* printf("\n H=%d \n",h); */ return po; } /************* Higher Back Matrix Product ***************/ /* double ***hbxij(double ***po, int nhstepm, double age, int hstepm, double *x, double ***prevacurrent, int nlstate, int stepm, double **oldm, double **savm, double **dnewm, double **doldm, double **dsavm, int ij ) */ -double ***hbxij(double ***po, int nhstepm, double age, int hstepm, double *x, double ***prevacurrent, int nlstate, int stepm, int ij ) +double ***hbxij(double ***po, int nhstepm, double age, int hstepm, double *x, double ***prevacurrent, int nlstate, int stepm, int ij, int nres ) { - /* Computes the transition matrix starting at age 'age' over + /* For a combination of dummy covariate ij, computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' months (i.e. until age (in years) age+nhstepm*hstepm*stepm/12) by multiplying nhstepm*hstepm matrices. @@ -3159,18 +3221,19 @@ double ***hbxij(double ***po, int nhstep (typically every 2 years instead of every month which is too big for the memory). Model is determined by parameters x and covariates have to be - included manually here. - + included manually here. Then we use a call to bmij(x and cov) + The addresss of po (p3mat allocated to the dimension of nhstepm) should be stored for output */ int i, j, d, h, k; - double **out, cov[NCOVMAX+1]; - double **newm; + double **out, cov[NCOVMAX+1], **bmij(); + double **newm, ***newmm; double agexact; double agebegin, ageend; double **oldm, **savm; - oldm=oldms;savm=savms; + newmm=po; /* To be saved */ + oldm=oldms;savm=savms; /* Global pointers */ /* Hstepm could be zero and should return the unit matrix */ for (i=1;i<=nlstate+ndeath;i++) for (j=1;j<=nlstate+ndeath;j++){ @@ -3183,27 +3246,38 @@ double ***hbxij(double ***po, int nhstep newm=savm; /* Covariates have to be included here again */ cov[1]=1.; - agexact=age-((h-1)*hstepm + (d-1))*stepm/YEARM; /* age just before transition */ + agexact=age-( (h-1)*hstepm + (d) )*stepm/YEARM; /* age just before transition, d or d-1? */ /* agexact=age+((h-1)*hstepm + (d-1))*stepm/YEARM; /\* age just before transition *\/ */ cov[2]=agexact; if(nagesqr==1) cov[3]= agexact*agexact; - for (k=1; k<=cptcovn;k++) - cov[2+nagesqr+k]=nbcode[Tvar[k]][codtabm(ij,k)]; - /* cov[2+nagesqr+k]=nbcode[Tvar[k]][codtabm(ij,Tvar[k])]; */ - for (k=1; k<=cptcovage;k++) /* Should start at cptcovn+1 */ - /* cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2]; */ - cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; - /* cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,Tvar[Tage[k]])]*cov[2]; */ - for (k=1; k<=cptcovprod;k++) /* Useless because included in cptcovn */ + for (k=1; k<=cptcovn;k++){ + /* cov[2+nagesqr+k]=nbcode[Tvar[k]][codtabm(ij,k)]; */ + /* /\* cov[2+nagesqr+k]=nbcode[Tvar[k]][codtabm(ij,Tvar[k])]; *\/ */ + cov[2+nagesqr+TvarsDind[k]]=nbcode[TvarsD[k]][codtabm(ij,k)]; + /* printf("hbxij Dummy agexact=%.0f combi=%d k=%d TvarsD[%d]=V%d TvarsDind[%d]=%d nbcode=%d cov[%d]=%lf codtabm(%d,Tvar[%d])=%d \n",agexact,ij,k, k, TvarsD[k],k,TvarsDind[k],nbcode[TvarsD[k]][codtabm(ij,k)],2+nagesqr+TvarsDind[k],cov[2+nagesqr+TvarsDind[k]], ij, k, codtabm(ij,k)); */ + } + for (k=1; k<=nsq;k++) { /* For single varying covariates only */ + /* Here comes the value of quantitative after renumbering k with single quantitative covariates */ + cov[2+nagesqr+TvarsQind[k]]=Tqresult[nres][k]; + /* printf("hPxij Quantitative k=%d TvarsQind[%d]=%d, TvarsQ[%d]=V%d,Tqresult[%d][%d]=%f\n",k,k,TvarsQind[k],k,TvarsQ[k],nres,k,Tqresult[nres][k]); */ + } + for (k=1; k<=cptcovage;k++){ /* Should start at cptcovn+1 */ + if(Dummy[Tvar[Tage[k]]]){ + cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; + } else{ + cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; + } + /* printf("hBxij Age combi=%d k=%d Tage[%d]=V%d Tqresult[%d][%d]=%f\n",ij,k,k,Tage[k],nres,k,Tqresult[nres][k]); */ + } + for (k=1; k<=cptcovprod;k++){ /* Useless because included in cptcovn */ cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)]*nbcode[Tvard[k][2]][codtabm(ij,k)]; - /* cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,Tvard[k][1])]*nbcode[Tvard[k][2]][codtabm(ij,Tvard[k][2])]; */ - - + } /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/ /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/ + /* Careful transposed matrix */ - /* age is in cov[2] */ + /* age is in cov[2], prevacurrent at beginning of transition. */ /* out=matprod2(newm, bmij(pmmij,cov,ncovmodel,x,nlstate,prevacurrent, dnewm, doldm, dsavm,ij),\ */ /* 1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm); */ out=matprod2(newm, bmij(pmmij,cov,ncovmodel,x,nlstate,prevacurrent,ij),\ @@ -3228,11 +3302,12 @@ double ***hbxij(double ***po, int nhstep for(i=1; i<=nlstate+ndeath; i++) for(j=1;j<=nlstate+ndeath;j++) { po[i][j][h]=newm[i][j]; - /*if(h==nhstepm) printf("po[%d][%d][%d]=%f ",i,j,h,po[i][j][h]);*/ + /* if(h==nhstepm) */ + /* printf("po[%d][%d][%d]=%f ",i,j,h,po[i][j][h]); */ } - /*printf("h=%d ",h);*/ + /* printf("h=%d %.1f ",h, agexact); */ } /* end h */ - /* printf("\n H=%d \n",h); */ + /* printf("\n H=%d nhs=%d \n",h, nhstepm); */ return po; } @@ -3687,7 +3762,7 @@ double funcone( double *x) s1=s[mw[mi][i]][i]; s2=s[mw[mi+1][i]][i]; /* if(s2==-1){ */ - /* printf(" s1=%d, s2=%d i=%d \n", s1, s2, i); */ + /* printf(" ERROR s1=%d, s2=%d i=%d \n", s1, s2, i); */ /* /\* exit(1); *\/ */ /* } */ bbh=(double)bh[mi][i]/(double)stepm; @@ -3720,7 +3795,7 @@ double funcone( double *x) fprintf(ficresilk,"%09ld %6.1f %6.1f %6d %2d %2d %2d %2d %3d %15.6f %8.4f %8.3f\ %11.6f %11.6f %11.6f ", \ num[i], agebegin, ageend, i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],weight[i]*gipmx/gsw, - 2*weight[i]*lli,out[s1][s2],savm[s1][s2]); + 2*weight[i]*lli,(s2==-1? -1: out[s1][s2]),(s2==-1? -1: savm[s1][s2])); for(k=1,llt=0.,l=0.; k<=nlstate; k++){ llt +=ll[k]*gipmx/gsw; fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw); @@ -4240,70 +4315,7 @@ void pstamp(FILE *fichier) fprintf(fichier,"# %s.%s\n#IMaCh version %s, %s\n#%s\n# %s", optionfilefiname,optionfilext,version,copyright, fullversion, strstart); } -int linreg(int ifi, int ila, int *no, const double x[], const double y[], double* a, double* b, double* r, double* sa, double * sb) { - /* y=a+bx regression */ - double sumx = 0.0; /* sum of x */ - double sumx2 = 0.0; /* sum of x**2 */ - double sumxy = 0.0; /* sum of x * y */ - double sumy = 0.0; /* sum of y */ - double sumy2 = 0.0; /* sum of y**2 */ - double sume2; /* sum of square or residuals */ - double yhat; - - double denom=0; - int i; - int ne=*no; - - for ( i=ifi, ne=0;i<=ila;i++) { - if(!isfinite(x[i]) || !isfinite(y[i])){ - /* printf(" x[%d]=%f, y[%d]=%f\n",i,x[i],i,y[i]); */ - continue; - } - ne=ne+1; - sumx += x[i]; - sumx2 += x[i]*x[i]; - sumxy += x[i] * y[i]; - sumy += y[i]; - sumy2 += y[i]*y[i]; - denom = (ne * sumx2 - sumx*sumx); - /* printf("ne=%d, i=%d,x[%d]=%f, y[%d]=%f sumx=%f, sumx2=%f, sumxy=%f, sumy=%f, sumy2=%f, denom=%f\n",ne,i,i,x[i],i,y[i], sumx, sumx2,sumxy, sumy, sumy2,denom); */ - } - - denom = (ne * sumx2 - sumx*sumx); - if (denom == 0) { - // vertical, slope m is infinity - *b = INFINITY; - *a = 0; - if (r) *r = 0; - return 1; - } - - *b = (ne * sumxy - sumx * sumy) / denom; - *a = (sumy * sumx2 - sumx * sumxy) / denom; - if (r!=NULL) { - *r = (sumxy - sumx * sumy / ne) / /* compute correlation coeff */ - sqrt((sumx2 - sumx*sumx/ne) * - (sumy2 - sumy*sumy/ne)); - } - *no=ne; - for ( i=ifi, ne=0;i<=ila;i++) { - if(!isfinite(x[i]) || !isfinite(y[i])){ - /* printf(" x[%d]=%f, y[%d]=%f\n",i,x[i],i,y[i]); */ - continue; - } - ne=ne+1; - yhat = y[i] - *a -*b* x[i]; - sume2 += yhat * yhat ; - - denom = (ne * sumx2 - sumx*sumx); - /* printf("ne=%d, i=%d,x[%d]=%f, y[%d]=%f sumx=%f, sumx2=%f, sumxy=%f, sumy=%f, sumy2=%f, denom=%f\n",ne,i,i,x[i],i,y[i], sumx, sumx2,sumxy, sumy, sumy2,denom); */ - } - *sb = sqrt(sume2/(ne-2)/(sumx2 - sumx * sumx /ne)); - *sa= *sb * sqrt(sumx2/ne); - - return 0; -} /************ Frequencies ********************/ void freqsummary(char fileres[], double p[], double pstart[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, \ @@ -4316,8 +4328,8 @@ void freqsummary(char fileres[], double int mi; /* Effective wave */ int first; double ***freq; /* Frequencies */ - double *x, *y, a,b,r, sa, sb; /* for regression, y=b+m*x and r is the correlation coefficient */ - int no; + double *x, *y, a=0.,b=0.,r=1., sa=0., sb=0.; /* for regression, y=b+m*x and r is the correlation coefficient */ + int no=0, linreg(int ifi, int ila, int *no, const double x[], const double y[], double* a, double* b, double* r, double* sa, double * sb); double *meanq; double **meanqt; double *pp, **prop, *posprop, *pospropt; @@ -4755,6 +4767,8 @@ Title=%s
Datafile=%s Firstpass=%d La y[iage]= log(freq[i][k][iage]/freq[i][i][iage]); /* printf("i=%d, k=%d, s1=%d, j1=%d, jj=%d, y[%d]=%f\n",i,k,s1,j1,jj, iage, y[iage]); */ } + /* Some are not finite, but linreg will ignore these ages */ + no=0; linreg(iagemin,iagemax,&no,x,y,&a,&b,&r, &sa, &sb ); /* y= a+b*x with standard errors */ pstart[s1]=b; pstart[s1-1]=a; @@ -4858,6 +4872,72 @@ Title=%s
Datafile=%s Firstpass=%d La /* End of freqsummary */ } +/* Simple linear regression */ +int linreg(int ifi, int ila, int *no, const double x[], const double y[], double* a, double* b, double* r, double* sa, double * sb) { + + /* y=a+bx regression */ + double sumx = 0.0; /* sum of x */ + double sumx2 = 0.0; /* sum of x**2 */ + double sumxy = 0.0; /* sum of x * y */ + double sumy = 0.0; /* sum of y */ + double sumy2 = 0.0; /* sum of y**2 */ + double sume2 = 0.0; /* sum of square or residuals */ + double yhat; + + double denom=0; + int i; + int ne=*no; + + for ( i=ifi, ne=0;i<=ila;i++) { + if(!isfinite(x[i]) || !isfinite(y[i])){ + /* printf(" x[%d]=%f, y[%d]=%f\n",i,x[i],i,y[i]); */ + continue; + } + ne=ne+1; + sumx += x[i]; + sumx2 += x[i]*x[i]; + sumxy += x[i] * y[i]; + sumy += y[i]; + sumy2 += y[i]*y[i]; + denom = (ne * sumx2 - sumx*sumx); + /* printf("ne=%d, i=%d,x[%d]=%f, y[%d]=%f sumx=%f, sumx2=%f, sumxy=%f, sumy=%f, sumy2=%f, denom=%f\n",ne,i,i,x[i],i,y[i], sumx, sumx2,sumxy, sumy, sumy2,denom); */ + } + + denom = (ne * sumx2 - sumx*sumx); + if (denom == 0) { + // vertical, slope m is infinity + *b = INFINITY; + *a = 0; + if (r) *r = 0; + return 1; + } + + *b = (ne * sumxy - sumx * sumy) / denom; + *a = (sumy * sumx2 - sumx * sumxy) / denom; + if (r!=NULL) { + *r = (sumxy - sumx * sumy / ne) / /* compute correlation coeff */ + sqrt((sumx2 - sumx*sumx/ne) * + (sumy2 - sumy*sumy/ne)); + } + *no=ne; + for ( i=ifi, ne=0;i<=ila;i++) { + if(!isfinite(x[i]) || !isfinite(y[i])){ + /* printf(" x[%d]=%f, y[%d]=%f\n",i,x[i],i,y[i]); */ + continue; + } + ne=ne+1; + yhat = y[i] - *a -*b* x[i]; + sume2 += yhat * yhat ; + + denom = (ne * sumx2 - sumx*sumx); + /* printf("ne=%d, i=%d,x[%d]=%f, y[%d]=%f sumx=%f, sumx2=%f, sumxy=%f, sumy=%f, sumy2=%f, denom=%f\n",ne,i,i,x[i],i,y[i], sumx, sumx2,sumxy, sumy, sumy2,denom); */ + } + *sb = sqrt(sume2/(double)(ne-2)/(sumx2 - sumx * sumx /(double)ne)); + *sa= *sb * sqrt(sumx2/ne); + + return 0; +} + /************ Prevalence ********************/ void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass) { @@ -4947,7 +5027,10 @@ void prevalence(double ***probs, double } else{ if(first==1){ first=0; - printf("Warning Observed prevalence probs[%d][%d][%d]=%lf because of lack of cases\nSee others in log file...\n",jk,i,j1,probs[i][jk][j1]); + printf("Warning Observed prevalence doesn't sum to 1 for state %d: probs[%d][%d][%d]=%lf because of lack of cases\nSee others in log file...\n",jk,i,jk, j1,probs[i][jk][j1]); + fprintf(ficlog,"Warning Observed prevalence doesn't sum to 1 for state %d: probs[%d][%d][%d]=%lf because of lack of cases\nSee others in log file...\n",jk,i,jk, j1,probs[i][jk][j1]); + }else{ + fprintf(ficlog,"Warning Observed prevalence doesn't sum to 1 for state %d: probs[%d][%d][%d]=%lf because of lack of cases\nSee others in log file...\n",jk,i,jk, j1,probs[i][jk][j1]); } } } @@ -5387,7 +5470,7 @@ void concatwav(int wav[], int **dh, int /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. nhstepm is the number of hstepm from age to agelim nstepm is the number of stepm from age to agelin. - Look at hpijx to understand the reason of that which relies in memory size + Look at hpijx to understand the reason which relies in memory size consideration and note for a fixed period like estepm months */ /* We decided (b) to get a life expectancy respecting the most precise curvature of the survival function given by stepm (the optimization length). Unfortunately it @@ -5618,7 +5701,8 @@ void concatwav(int wav[], int **dh, int /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/ } - + + /* Standard deviation of expectancies ij */ fprintf(ficresstdeij,"%3.0f",age ); for(i=1; i<=nlstate;i++){ eip=0.; @@ -5633,6 +5717,7 @@ void concatwav(int wav[], int **dh, int } fprintf(ficresstdeij,"\n"); + /* Variance of expectancies ij */ fprintf(ficrescveij,"%3.0f",age ); for(i=1; i<=nlstate;i++) for(j=1; j<=nlstate;j++){ @@ -5986,12 +6071,12 @@ void concatwav(int wav[], int **dh, int } /* end varevsij */ /************ Variance of prevlim ******************/ - void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int *ncvyearp, int ij, char strstart[], int nres) + void varprevlim(char fileresvpl[], FILE *ficresvpl, double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int *ncvyearp, int ij, char strstart[], int nres) { /* Variance of prevalence limit for each state ij using current parameters x[] and estimates of neighbourhood give by delti*/ /* double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/ - double **dnewm,**doldm; + double **dnewmpar,**doldm; int i, j, nhstepm, hstepm; double *xp; double *gp, *gm; @@ -6010,7 +6095,7 @@ void concatwav(int wav[], int **dh, int fprintf(ficresvpl,"\n"); xp=vector(1,npar); - dnewm=matrix(1,nlstate,1,npar); + dnewmpar=matrix(1,nlstate,1,npar); doldm=matrix(1,nlstate,1,nlstate); hstepm=1*YEARM; /* Every year of age */ @@ -6080,11 +6165,11 @@ void concatwav(int wav[], int **dh, int for(i=1;i<=nlstate;i++) varpl[i][(int)age] =0.; if((int)age==79 ||(int)age== 80 ||(int)age== 81){ - matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov); - matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg); + matprod2(dnewmpar,trgradg,1,nlstate,1,npar,1,npar,matcov); + matprod2(doldm,dnewmpar,1,nlstate,1,npar,1,nlstate,gradg); }else{ - matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov); - matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg); + matprod2(dnewmpar,trgradg,1,nlstate,1,npar,1,npar,matcov); + matprod2(doldm,dnewmpar,1,nlstate,1,npar,1,nlstate,gradg); } for(i=1;i<=nlstate;i++) varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */ @@ -6105,70 +6190,195 @@ void concatwav(int wav[], int **dh, int free_vector(xp,1,npar); free_matrix(doldm,1,nlstate,1,npar); - free_matrix(dnewm,1,nlstate,1,nlstate); + free_matrix(dnewmpar,1,nlstate,1,nlstate); } -/************ Variance of one-step probabilities ******************/ -void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[]) - { - int i, j=0, k1, l1, tj; - int k2, l2, j1, z1; - int k=0, l; - int first=1, first1, first2; - double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp; - double **dnewm,**doldm; - double *xp; - double *gp, *gm; - double **gradg, **trgradg; - double **mu; - double age, cov[NCOVMAX+1]; - double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */ - int theta; - char fileresprob[FILENAMELENGTH]; - char fileresprobcov[FILENAMELENGTH]; - char fileresprobcor[FILENAMELENGTH]; - double ***varpij; - - strcpy(fileresprob,"PROB_"); - strcat(fileresprob,fileres); - if((ficresprob=fopen(fileresprob,"w"))==NULL) { - printf("Problem with resultfile: %s\n", fileresprob); - fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob); - } - strcpy(fileresprobcov,"PROBCOV_"); - strcat(fileresprobcov,fileresu); - if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) { - printf("Problem with resultfile: %s\n", fileresprobcov); - fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov); - } - strcpy(fileresprobcor,"PROBCOR_"); - strcat(fileresprobcor,fileresu); - if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) { - printf("Problem with resultfile: %s\n", fileresprobcor); - fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor); - } - printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob); - fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob); - printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov); - fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov); - printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor); - fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor); - pstamp(ficresprob); - fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n"); - fprintf(ficresprob,"# Age"); - pstamp(ficresprobcov); - fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n"); - fprintf(ficresprobcov,"# Age"); - pstamp(ficresprobcor); - fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n"); - fprintf(ficresprobcor,"# Age"); +/************ Variance of backprevalence limit ******************/ + void varbrevlim(char fileresvbl[], FILE *ficresvbl, double **varbpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **bprlim, double ftolpl, int mobilavproj, int *ncvyearp, int ij, char strstart[], int nres) +{ + /* Variance of backward prevalence limit for each state ij using current parameters x[] and estimates of neighbourhood give by delti*/ + /* double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/ - for(i=1; i<=nlstate;i++) - for(j=1; j<=(nlstate+ndeath);j++){ - fprintf(ficresprob," p%1d-%1d (SE)",i,j); - fprintf(ficresprobcov," p%1d-%1d ",i,j); + double **dnewmpar,**doldm; + int i, j, nhstepm, hstepm; + double *xp; + double *gp, *gm; + double **gradg, **trgradg; + double **mgm, **mgp; + double age,agelim; + int theta; + + pstamp(ficresvbl); + fprintf(ficresvbl,"# Standard deviation of back (stable) prevalences \n"); + fprintf(ficresvbl,"# Age "); + if(nresult >=1) + fprintf(ficresvbl," Result# "); + for(i=1; i<=nlstate;i++) + fprintf(ficresvbl," %1d-%1d",i,i); + fprintf(ficresvbl,"\n"); + + xp=vector(1,npar); + dnewmpar=matrix(1,nlstate,1,npar); + doldm=matrix(1,nlstate,1,nlstate); + + hstepm=1*YEARM; /* Every year of age */ + hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ + agelim = AGEINF; + for (age=fage; age>=bage; age --){ /* If stepm=6 months */ + nhstepm=(int) rint((age-agelim)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ + if (stepm >= YEARM) hstepm=1; + nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */ + gradg=matrix(1,npar,1,nlstate); + mgp=matrix(1,npar,1,nlstate); + mgm=matrix(1,npar,1,nlstate); + gp=vector(1,nlstate); + gm=vector(1,nlstate); + + for(theta=1; theta <=npar; theta++){ + for(i=1; i<=npar; i++){ /* Computes gradient */ + xp[i] = x[i] + (i==theta ?delti[theta]:0); + } + if(mobilavproj > 0 ) + bprevalim(bprlim, mobaverage,nlstate,xp,age,ftolpl,ncvyearp,ij,nres); + else + bprevalim(bprlim, mobaverage,nlstate,xp,age,ftolpl,ncvyearp,ij,nres); + for(i=1;i<=nlstate;i++){ + gp[i] = bprlim[i][i]; + mgp[theta][i] = bprlim[i][i]; + } + for(i=1; i<=npar; i++) /* Computes gradient */ + xp[i] = x[i] - (i==theta ?delti[theta]:0); + if(mobilavproj > 0 ) + bprevalim(bprlim, mobaverage,nlstate,xp,age,ftolpl,ncvyearp,ij,nres); + else + bprevalim(bprlim, mobaverage,nlstate,xp,age,ftolpl,ncvyearp,ij,nres); + for(i=1;i<=nlstate;i++){ + gm[i] = bprlim[i][i]; + mgm[theta][i] = bprlim[i][i]; + } + for(i=1;i<=nlstate;i++) + gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta]; + /* gradg[theta][2]= -gradg[theta][1]; */ /* For testing if nlstate=2 */ + } /* End theta */ + + trgradg =matrix(1,nlstate,1,npar); + + for(j=1; j<=nlstate;j++) + for(theta=1; theta <=npar; theta++) + trgradg[j][theta]=gradg[theta][j]; + /* if((int)age==79 ||(int)age== 80 ||(int)age== 81 ){ */ + /* printf("\nmgm mgp %d ",(int)age); */ + /* for(j=1; j<=nlstate;j++){ */ + /* printf(" %d ",j); */ + /* for(theta=1; theta <=npar; theta++) */ + /* printf(" %d %lf %lf",theta,mgm[theta][j],mgp[theta][j]); */ + /* printf("\n "); */ + /* } */ + /* } */ + /* if((int)age==79 ||(int)age== 80 ||(int)age== 81 ){ */ + /* printf("\n gradg %d ",(int)age); */ + /* for(j=1; j<=nlstate;j++){ */ + /* printf("%d ",j); */ + /* for(theta=1; theta <=npar; theta++) */ + /* printf("%d %lf ",theta,gradg[theta][j]); */ + /* printf("\n "); */ + /* } */ + /* } */ + + for(i=1;i<=nlstate;i++) + varbpl[i][(int)age] =0.; + if((int)age==79 ||(int)age== 80 ||(int)age== 81){ + matprod2(dnewmpar,trgradg,1,nlstate,1,npar,1,npar,matcov); + matprod2(doldm,dnewmpar,1,nlstate,1,npar,1,nlstate,gradg); + }else{ + matprod2(dnewmpar,trgradg,1,nlstate,1,npar,1,npar,matcov); + matprod2(doldm,dnewmpar,1,nlstate,1,npar,1,nlstate,gradg); + } + for(i=1;i<=nlstate;i++) + varbpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */ + + fprintf(ficresvbl,"%.0f ",age ); + if(nresult >=1) + fprintf(ficresvbl,"%d ",nres ); + for(i=1; i<=nlstate;i++) + fprintf(ficresvbl," %.5f (%.5f)",bprlim[i][i],sqrt(varbpl[i][(int)age])); + fprintf(ficresvbl,"\n"); + free_vector(gp,1,nlstate); + free_vector(gm,1,nlstate); + free_matrix(mgm,1,npar,1,nlstate); + free_matrix(mgp,1,npar,1,nlstate); + free_matrix(gradg,1,npar,1,nlstate); + free_matrix(trgradg,1,nlstate,1,npar); + } /* End age */ + + free_vector(xp,1,npar); + free_matrix(doldm,1,nlstate,1,npar); + free_matrix(dnewmpar,1,nlstate,1,nlstate); + +} + +/************ Variance of one-step probabilities ******************/ +void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[]) + { + int i, j=0, k1, l1, tj; + int k2, l2, j1, z1; + int k=0, l; + int first=1, first1, first2; + double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp; + double **dnewm,**doldm; + double *xp; + double *gp, *gm; + double **gradg, **trgradg; + double **mu; + double age, cov[NCOVMAX+1]; + double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */ + int theta; + char fileresprob[FILENAMELENGTH]; + char fileresprobcov[FILENAMELENGTH]; + char fileresprobcor[FILENAMELENGTH]; + double ***varpij; + + strcpy(fileresprob,"PROB_"); + strcat(fileresprob,fileres); + if((ficresprob=fopen(fileresprob,"w"))==NULL) { + printf("Problem with resultfile: %s\n", fileresprob); + fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob); + } + strcpy(fileresprobcov,"PROBCOV_"); + strcat(fileresprobcov,fileresu); + if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) { + printf("Problem with resultfile: %s\n", fileresprobcov); + fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov); + } + strcpy(fileresprobcor,"PROBCOR_"); + strcat(fileresprobcor,fileresu); + if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) { + printf("Problem with resultfile: %s\n", fileresprobcor); + fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor); + } + printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob); + fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob); + printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov); + fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov); + printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor); + fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor); + pstamp(ficresprob); + fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n"); + fprintf(ficresprob,"# Age"); + pstamp(ficresprobcov); + fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n"); + fprintf(ficresprobcov,"# Age"); + pstamp(ficresprobcor); + fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n"); + fprintf(ficresprobcor,"# Age"); + + + for(i=1; i<=nlstate;i++) + for(j=1; j<=(nlstate+ndeath);j++){ + fprintf(ficresprob," p%1d-%1d (SE)",i,j); + fprintf(ficresprobcov," p%1d-%1d ",i,j); fprintf(ficresprobcor," p%1d-%1d ",i,j); } /* fprintf(ficresprob,"\n"); @@ -6185,7 +6395,7 @@ void varprob(char optionfilefiname[], do fprintf(fichtm,"\n
  • Computing and drawing one step probabilities with their confidence intervals

  • \n"); fprintf(fichtm,"\n"); - fprintf(fichtm,"\n
  • Matrix of variance-covariance of one-step probabilities (drawings)

    this page is important in order to visualize confidence intervals and especially correlation between disability and recovery, or more generally, way in and way back.
  • \n",optionfilehtmcov); + fprintf(fichtm,"\n
  • Matrix of variance-covariance of one-step probabilities (drawings)

    this page is important in order to visualize confidence intervals and especially correlation between disability and recovery, or more generally, way in and way back. %s
  • \n",optionfilehtmcov,optionfilehtmcov); fprintf(fichtmcov,"Current page is file %s
    \n\n

    Matrix of variance-covariance of pairs of step probabilities

    \n",optionfilehtmcov, optionfilehtmcov); fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (pij, pkl) are estimated \ and drawn. It helps understanding how is the covariance between two incidences.\ @@ -6402,7 +6612,7 @@ To be simple, these graphs help to under fprintf(ficgp,"\nset parametric;unset label"); fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2); fprintf(ficgp,"\nset ter svg size 640, 480"); - fprintf(fichtmcov,"\n
    Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year-1\ + fprintf(fichtmcov,"\n


    Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year-1\ : \ %s_%d%1d%1d-%1d%1d.svg, ",k1,l1,k2,l2,\ subdirf2(optionfilefiname,"VARPIJGR_"), j1,k1,l1,k2,l2, \ @@ -6413,16 +6623,16 @@ To be simple, these graphs help to under fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2); fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2); fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not", \ - mu1,std,v11,sqrt(lc1),v12,sqrt(lc2), \ - mu2,std,v21,sqrt(lc1),v22,sqrt(lc2)); + mu1,std,v11,sqrt(lc1),v12,sqrt(fabs(lc2)), \ + mu2,std,v21,sqrt(lc1),v22,sqrt(fabs(lc2))); /* For gnuplot only */ }else{ first=0; fprintf(fichtmcov," %d (%.3f),",(int) age, c12); fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2); fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2); fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not", \ - mu1,std,v11,sqrt(lc1),v12,sqrt(lc2), \ - mu2,std,v21,sqrt(lc1),v22,sqrt(lc2)); + mu1,std,v11,sqrt(lc1),v12,sqrt(fabs(lc2)), \ + mu2,std,v21,sqrt(lc1),v22,sqrt(fabs(lc2))); }/* if first */ } /* age mod 5 */ } /* end loop age */ @@ -6606,10 +6816,17 @@ divided by h: hPij if(prevfcast==1){ /* Projection of prevalence up to period (stable) prevalence in each health state */ for(cpt=1; cpt<=nlstate;cpt++){ - fprintf(fichtm,"
    \n- Projection of cross-sectional prevalence (estimated with cases observed from %.1f to %.1f and mobil_average=%d) up to period (stable) prevalence in state %d. Or probability to be in state %d being in state (1 to %d) at different ages. %s_%d-%d-%d.svg
    \ + fprintf(fichtm,"
    \n- Projection of cross-sectional prevalence (estimated with cases observed from %.1f to %.1f and mobil_average=%d) up to period (stable) prevalence in state %d. Or probability to be in state %d being in an observed weighted state (from 1 to %d). %s_%d-%d-%d.svg
    \ ", dateprev1, dateprev2, mobilavproj, cpt, cpt, nlstate, subdirf2(optionfilefiname,"PROJ_"),cpt,k1,nres,subdirf2(optionfilefiname,"PROJ_"),cpt,k1,nres,subdirf2(optionfilefiname,"PROJ_"),cpt,k1,nres); } } + if(backcast==1){ + /* Back projection of prevalence up to stable (mixed) back-prevalence in each health state */ + for(cpt=1; cpt<=nlstate;cpt++){ + fprintf(fichtm,"
    \n- Back projection of cross-sectional prevalence (estimated with cases observed from %.1f to %.1f and mobil_average=%d) up to stable (mixed) back prevalence in state %d. Or probability to have been in an state %d, knowing that the person was in either state (1 or %d) with weights corresponding to observed prevalence at different ages. %s_%d-%d-%d.svg
    \ +", dateprev1, dateprev2, mobilavproj, cpt, cpt, nlstate, subdirf2(optionfilefiname,"PROJB_"),cpt,k1,nres,subdirf2(optionfilefiname,"PROJB_"),cpt,k1,nres,subdirf2(optionfilefiname,"PROJB_"),cpt,k1,nres); + } + } for(cpt=1; cpt<=nlstate;cpt++) { fprintf(fichtm,"\n
    - Life expectancy by health state (%d) at initial age and its decomposition into health expectancies in each alive state (1 to %d) (or area under each survival functions): %s_%d-%d-%d.svg
    \ @@ -6713,7 +6930,7 @@ true period expectancies (those weighted } /******************* Gnuplot file **************/ -void printinggnuplot(char fileresu[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , int prevfcast, int backcast, char pathc[], double p[]){ +void printinggnuplot(char fileresu[], char optionfilefiname[], double ageminpar, double agemaxpar, double bage, double fage , int prevfcast, int backcast, char pathc[], double p[], int offyear, int offbyear){ char dirfileres[132],optfileres[132]; char gplotcondition[132], gplotlabel[132]; @@ -6722,7 +6939,10 @@ void printinggnuplot(char fileresu[], ch int ng=0; int vpopbased; int ioffset; /* variable offset for columns */ + int iyearc=1; /* variable column for year of projection */ + int iagec=1; /* variable column for age of projection */ int nres=0; /* Index of resultline */ + int istart=1; /* For starting graphs in projections */ /* if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */ /* printf("Problem with file %s",optionfilegnuplot); */ @@ -6825,7 +7045,7 @@ void printinggnuplot(char fileresu[], ch fprintf(ficgp,"\" t\"\" w l lt 1,\"%s\" u 1:((",subdirf2(fileresu,"P_")); if(cptcoveff ==0){ - fprintf(ficgp,"$%d)) t 'Observed prevalence in state %d' with line lt 3", 2+(cpt-1), cpt ); + fprintf(ficgp,"$%d)) t 'Observed prevalence in state %d' with line lt 3", 2+3*(cpt-1), cpt ); }else{ kl=0; for (k=1; k<=cptcoveff; k++){ /* For each combination of covariate */ @@ -6876,6 +7096,25 @@ void printinggnuplot(char fileresu[], ch } } /* end covariate */ } /* end if no covariate */ + if(backcast == 1){ + fprintf(ficgp,", \"%s\" every :::%d::%d u 1:($2==%d ? $3:1/0) \"%%lf %%lf",subdirf2(fileresu,"VBL_"),nres-1,nres-1,nres); + /* k1-1 error should be nres-1*/ + for (i=1; i<= nlstate ; i ++) { + if (i==cpt) fprintf(ficgp," %%lf (%%lf)"); + else fprintf(ficgp," %%*lf (%%*lf)"); + } + fprintf(ficgp,"\" t\"Backward (stable) prevalence\" w l lt 6 dt 3,\"%s\" every :::%d::%d u 1:($2==%d ? $3+1.96*$4 : 1/0) \"%%lf %%lf",subdirf2(fileresu,"VBL_"),nres-1,nres-1,nres); + for (i=1; i<= nlstate ; i ++) { + if (i==cpt) fprintf(ficgp," %%lf (%%lf)"); + else fprintf(ficgp," %%*lf (%%*lf)"); + } + fprintf(ficgp,"\" t\"95%% CI\" w l lt 6,\"%s\" every :::%d::%d u 1:($2==%d ? $3-1.96*$4 : 1/0) \"%%lf %%lf",subdirf2(fileresu,"VBL_"),nres-1,nres-1,nres); + for (i=1; i<= nlstate ; i ++) { + if (i==cpt) fprintf(ficgp," %%lf (%%lf)"); + else fprintf(ficgp," %%*lf (%%*lf)"); + } + fprintf(ficgp,"\" t\"\" w l lt 6"); + } /* end if backprojcast */ } /* end if backcast */ fprintf(ficgp,"\nset out ;unset label;\n"); } /* nres */ @@ -7169,7 +7408,7 @@ set ter svg size 640, 480\nunset log y\n for(nres=1; nres <= nresult; nres++){ /* For each resultline */ if(m != 1 && TKresult[nres]!= k1) continue; - for (cpt=1; cpt<=nlstate ; cpt ++) { /* For each life ending state */ + for (cpt=1; cpt<=nlstate ; cpt ++) { /* For each life origin state */ strcpy(gplotlabel,"("); fprintf(ficgp,"\n#\n#\n#CV Back preval stable (period): 'pijb' files, covariatecombination#=%d state=%d",k1, cpt); for (k=1; k<=cptcoveff; k++){ /* For each covariate and each value */ @@ -7193,11 +7432,11 @@ set ter svg size 640, 480\nunset log y\n } fprintf(ficgp,"\nset out \"%s_%d-%d-%d.svg\" \n",subdirf2(optionfilefiname,"PB_"),cpt,k1,nres); - fprintf(ficgp,"set label \"Ending alive state %d %s\" at graph 0.98,0.5 center rotate font \"Helvetica,12\"\n",cpt,gplotlabel); + fprintf(ficgp,"set label \"Origin alive state %d %s\" at graph 0.98,0.5 center rotate font \"Helvetica,12\"\n",cpt,gplotlabel); fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\ set ter svg size 640, 480\nunset log y\nplot [%.f:%.f] ", ageminpar, agemaxpar); k=3; /* Offset */ - for (i=1; i<= nlstate ; i ++){ /* State of origin */ + for (i=1; i<= nlstate ; i ++){ /* State of arrival */ if(i==1) fprintf(ficgp,"\"%s\"",subdirf2(fileresu,"PIJB_")); else @@ -7210,7 +7449,7 @@ set ter svg size 640, 480\nunset log y\n /* for (j=2; j<= nlstate ; j ++) */ /* fprintf(ficgp,"+$%d",k+l+j-1); */ /* /\* fprintf(ficgp,"+$%d",k+l+j-1); *\/ */ - fprintf(ficgp,") t \"bprev(%d,%d)\" w l",i,cpt); + fprintf(ficgp,") t \"bprev(%d,%d)\" w l",cpt,i); } /* nlstate */ fprintf(ficgp,"\nset out; unset label;\n"); } /* end cpt state*/ @@ -7253,12 +7492,16 @@ set ter svg size 640, 480\nunset log y\n fprintf(ficgp,"set label \"Alive state %d %s\" at graph 0.98,0.5 center rotate font \"Helvetica,12\"\n",cpt,gplotlabel); fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Prevalence\" \n\ set ter svg size 640, 480\nunset log y\nplot [%.f:%.f] ", ageminpar, agemaxpar); - for (i=1; i<= nlstate+1 ; i ++){ /* nlstate +1 p11 p21 p.1 */ + + /* for (i=1; i<= nlstate+1 ; i ++){ /\* nlstate +1 p11 p21 p.1 *\/ */ + istart=nlstate+1; /* Could be one if by state, but nlstate+1 is w.i projection only */ + /*istart=1;*/ /* Could be one if by state, but nlstate+1 is w.i projection only */ + for (i=istart; i<= nlstate+1 ; i ++){ /* nlstate +1 p11 p21 p.1 */ /*# V1 = 1 V2 = 0 yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ /*# yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ - if(i==1){ + if(i==istart){ fprintf(ficgp,"\"%s\"",subdirf2(fileresu,"F_")); }else{ fprintf(ficgp,",\\\n '' "); @@ -7270,20 +7513,23 @@ set ter svg size 640, 480\nunset log y\n /*# V1 = 1 yearproj age p11 p21 p31 p.1 p12 p22 p32 p.2 p13 p23 p33 p.3 p14 p24 p34 p.4*/ /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 */ fprintf(ficgp," u %d:(", ioffset); - if(i==nlstate+1) - fprintf(ficgp," $%d/(1.-$%d)) t 'pw.%d' with line ", \ + if(i==nlstate+1){ + fprintf(ficgp," $%d/(1.-$%d)):1 t 'pw.%d' with line lc variable ", \ ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate,cpt ); - else + fprintf(ficgp,",\\\n '' "); + fprintf(ficgp," u %d:(",ioffset); + fprintf(ficgp," (($1-$2) == %d ) ? $%d/(1.-$%d) : 1/0):1 with labels center not ", \ + offyear, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate ); + }else fprintf(ficgp," $%d/(1.-$%d)) t 'p%d%d' with line ", \ ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate,i,cpt ); }else{ /* more than 2 covariates */ - if(cptcoveff ==1){ - ioffset=4; /* Age is in 4 */ - }else{ - ioffset=6; /* Age is in 6 */ - /*# V1 = 1 V2 = 0 yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ - /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ - } + ioffset=2*cptcoveff+2; /* Age is in 4 or 6 or etc.*/ + /*# V1 = 1 V2 = 0 yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ + /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ + iyearc=ioffset-1; + iagec=ioffset; fprintf(ficgp," u %d:(",ioffset); kl=0; strcpy(gplotcondition,"("); @@ -7305,8 +7551,14 @@ set ter svg size 640, 480\nunset log y\n /*6+1+(i-1)+(nlstate+1)*nlstate; 6+1+(1-1) +(2+1)*2=13 */ /* '' u 6:(($1==1 && $2==0 && $3==2 && $4==0)? $9/(1.-$15) : 1/0):($5==2000? 3:2) t 'p.1' with line lc variable*/ if(i==nlstate+1){ - fprintf(ficgp,"%s ? $%d/(1.-$%d) : 1/0) t 'p.%d' with line ", gplotcondition, \ - ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate,cpt ); + fprintf(ficgp,"%s ? $%d/(1.-$%d) : 1/0):%d t 'p.%d' with line lc variable", gplotcondition, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate,iyearc, cpt ); + fprintf(ficgp,",\\\n '' "); + fprintf(ficgp," u %d:(",iagec); + fprintf(ficgp,"%s && (($%d-$%d) == %d ) ? $%d/(1.-$%d) : 1/0):%d with labels center not ", gplotcondition, \ + iyearc, iagec, offyear, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate, iyearc ); +/* '' u 6:(($1==1 && $2==0 && $3==2 && $4==0) && (($5-$6) == 1947) ? $10/(1.-$22) : 1/0):5 with labels center boxed not*/ }else{ fprintf(ficgp,"%s ? $%d/(1.-$%d) : 1/0) t 'p%d%d' with line ", gplotcondition, \ ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset +1+(i-1)+(nlstate+1)*nlstate,i,cpt ); @@ -7318,6 +7570,121 @@ set ter svg size 640, 480\nunset log y\n } /* end covariate */ } /* End if prevfcast */ + if(backcast==1){ + /* Back projection from cross-sectional to stable (mixed) for each covariate */ + + for (k1=1; k1<= m ; k1 ++) /* For each covariate combination if any */ + for(nres=1; nres <= nresult; nres++){ /* For each resultline */ + if(m != 1 && TKresult[nres]!= k1) + continue; + for (cpt=1; cpt<=nlstate ; cpt ++) { /* For each life state */ + strcpy(gplotlabel,"("); + fprintf(ficgp,"\n#\n#\n#Back projection of prevalence to stable (mixed) back prevalence: 'BPROJ_' files, covariatecombination#=%d originstate=%d",k1, cpt); + for (k=1; k<=cptcoveff; k++){ /* For each correspondig covariate value */ + lv= decodtabm(k1,k,cptcoveff); /* Should be the covariate value corresponding to k1 combination and kth covariate */ + /* decodtabm(1,1,4) = 1 because h=1 k= (1) 1 1 1 */ + /* decodtabm(1,2,4) = 1 because h=1 k= 1 (1) 1 1 */ + /* decodtabm(13,3,4)= 2 because h=13 k= 1 1 (2) 2 */ + vlv= nbcode[Tvaraff[k]][lv]; + fprintf(ficgp," V%d=%d ",Tvaraff[k],vlv); + sprintf(gplotlabel+strlen(gplotlabel)," V%d=%d ",Tvaraff[k],vlv); + } + for (k4=1; k4<= nsq; k4++){ /* For each selected (single) quantitative value */ + fprintf(ficgp," V%d=%f ",Tvqresult[nres][k4],Tqresult[nres][k4]); + sprintf(gplotlabel+strlen(gplotlabel)," V%d=%f ",Tvqresult[nres][k4],Tqresult[nres][k4]); + } + strcpy(gplotlabel+strlen(gplotlabel),")"); + fprintf(ficgp,"\n#\n"); + if(invalidvarcomb[k1]){ + fprintf(ficgp,"#Combination (%d) ignored because no cases \n",k1); + continue; + } + + fprintf(ficgp,"# hbijx=backprobability over h years, hb.jx is weighted by observed prev at destination state\n "); + fprintf(ficgp,"\nset out \"%s_%d-%d-%d.svg\" \n",subdirf2(optionfilefiname,"PROJB_"),cpt,k1,nres); + fprintf(ficgp,"set label \"Origin alive state %d %s\" at graph 0.98,0.5 center rotate font \"Helvetica,12\"\n",cpt,gplotlabel); + fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Prevalence\" \n\ +set ter svg size 640, 480\nunset log y\nplot [%.f:%.f] ", ageminpar, agemaxpar); + + /* for (i=1; i<= nlstate+1 ; i ++){ /\* nlstate +1 p11 p21 p.1 *\/ */ + istart=nlstate+1; /* Could be one if by state, but nlstate+1 is w.i projection only */ + /*istart=1;*/ /* Could be one if by state, but nlstate+1 is w.i projection only */ + for (i=istart; i<= nlstate+1 ; i ++){ /* nlstate +1 p11 p21 p.1 */ + /*# V1 = 1 V2 = 0 yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ + /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ + /*# yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ + /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ + if(i==istart){ + fprintf(ficgp,"\"%s\"",subdirf2(fileresu,"FB_")); + }else{ + fprintf(ficgp,",\\\n '' "); + } + if(cptcoveff ==0){ /* No covariate */ + ioffset=2; /* Age is in 2 */ + /*# yearproj age p11 p21 p31 p.1 p12 p22 p32 p.2 p13 p23 p33 p.3 p14 p24 p34 p.4*/ + /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 */ + /*# V1 = 1 yearproj age p11 p21 p31 p.1 p12 p22 p32 p.2 p13 p23 p33 p.3 p14 p24 p34 p.4*/ + /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 */ + fprintf(ficgp," u %d:(", ioffset); + if(i==nlstate+1){ + fprintf(ficgp," $%d/(1.-$%d)):1 t 'bw%d' with line lc variable ", \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate,cpt ); + fprintf(ficgp,",\\\n '' "); + fprintf(ficgp," u %d:(",ioffset); + fprintf(ficgp," (($1-$2) == %d ) ? $%d : 1/0):1 with labels center not ", \ + offbyear, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1) ); + }else + fprintf(ficgp," $%d/(1.-$%d)) t 'b%d%d' with line ", \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), ioffset+1+(i-1)+(nlstate+1)*nlstate,cpt,i ); + }else{ /* more than 2 covariates */ + ioffset=2*cptcoveff+2; /* Age is in 4 or 6 or etc.*/ + /*# V1 = 1 V2 = 0 yearproj age p11 p21 p.1 p12 p22 p.2 p13 p23 p.3*/ + /*# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 */ + iyearc=ioffset-1; + iagec=ioffset; + fprintf(ficgp," u %d:(",ioffset); + kl=0; + strcpy(gplotcondition,"("); + for (k=1; k<=cptcoveff; k++){ /* For each covariate writing the chain of conditions */ + lv= decodtabm(k1,k,cptcoveff); /* Should be the covariate value corresponding to combination k1 and covariate k */ + /* decodtabm(1,1,4) = 1 because h=1 k= (1) 1 1 1 */ + /* decodtabm(1,2,4) = 1 because h=1 k= 1 (1) 1 1 */ + /* decodtabm(13,3,4)= 2 because h=13 k= 1 1 (2) 2 */ + vlv= nbcode[Tvaraff[k]][lv]; /* Value of the modality of Tvaraff[k] */ + kl++; + sprintf(gplotcondition+strlen(gplotcondition),"$%d==%d && $%d==%d " ,kl,Tvaraff[k], kl+1, nbcode[Tvaraff[k]][lv]); + kl++; + if(k 1) + sprintf(gplotcondition+strlen(gplotcondition)," && "); + } + strcpy(gplotcondition+strlen(gplotcondition),")"); + /* kl=6+(cpt-1)*(nlstate+1)+1+(i-1); /\* 6+(1-1)*(2+1)+1+(1-1)=7, 6+(2-1)(2+1)+1+(1-1)=10 *\/ */ + /*6+(cpt-1)*(nlstate+1)+1+(i-1)+(nlstate+1)*nlstate; 6+(1-1)*(2+1)+1+(1-1) +(2+1)*2=13 */ + /*6+1+(i-1)+(nlstate+1)*nlstate; 6+1+(1-1) +(2+1)*2=13 */ + /* '' u 6:(($1==1 && $2==0 && $3==2 && $4==0)? $9/(1.-$15) : 1/0):($5==2000? 3:2) t 'p.1' with line lc variable*/ + if(i==nlstate+1){ + fprintf(ficgp,"%s ? $%d : 1/0):%d t 'bw%d' with line lc variable", gplotcondition, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1),iyearc,cpt ); + fprintf(ficgp,",\\\n '' "); + fprintf(ficgp," u %d:(",iagec); + /* fprintf(ficgp,"%s && (($5-$6) == %d ) ? $%d/(1.-$%d) : 1/0):5 with labels center not ", gplotcondition, \ */ + fprintf(ficgp,"%s && (($%d-$%d) == %d ) ? $%d : 1/0):%d with labels center not ", gplotcondition, \ + iyearc,iagec,offbyear, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), iyearc ); +/* '' u 6:(($1==1 && $2==0 && $3==2 && $4==0) && (($5-$6) == 1947) ? $10/(1.-$22) : 1/0):5 with labels center boxed not*/ + }else{ + /* fprintf(ficgp,"%s ? $%d/(1.-$%d) : 1/0) t 'p%d%d' with line ", gplotcondition, \ */ + fprintf(ficgp,"%s ? $%d : 1/0) t 'b%d%d' with line ", gplotcondition, \ + ioffset+(cpt-1)*(nlstate+1)+1+(i-1), cpt,i ); + } + } /* end if covariate */ + } /* nlstate */ + fprintf(ficgp,"\nset out; unset label;\n"); + } /* end cpt state*/ + } /* end covariate */ + } /* End if backcast */ + /* 9eme writing MLE parameters */ fprintf(ficgp,"\n##############\n#9eme MLE estimated parameters\n#############\n"); @@ -7424,36 +7791,40 @@ set ter svg size 640, 480\nunset log y\n /* for(j=3; j <=ncovmodel-nagesqr; j++) { */ for(j=1; j <=cptcovt; j++) { /* For each covariate of the simplified model */ /* printf("Tage[%d]=%d, j=%d\n", ij, Tage[ij], j); */ - if(j==Tage[ij]) { /* Product by age */ - if(ij <=cptcovage) { /* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1, 2 V5 and V1 */ - if(DummyV[j]==0){ - fprintf(ficgp,"+p%d*%d*x",i+j+2+nagesqr-1,Tinvresult[nres][Tvar[j]]);; - }else{ /* quantitative */ - fprintf(ficgp,"+p%d*%f*x",i+j+2+nagesqr-1,Tqinvresult[nres][Tvar[j]]); /* Tqinvresult in decoderesult */ - /* fprintf(ficgp,"+p%d*%d*x",i+j+nagesqr-1,nbcode[Tvar[j-2]][codtabm(k1,Tvar[j-2])]); */ - } - ij++; - } - }else if(j==Tprod[ijp]) { /* */ - /* printf("Tprod[%d]=%d, j=%d\n", ij, Tprod[ijp], j); */ - if(ijp <=cptcovprod) { /* Product */ - if(DummyV[Tvard[ijp][1]]==0){/* Vn is dummy */ - if(DummyV[Tvard[ijp][2]]==0){/* Vn and Vm are dummy */ - /* fprintf(ficgp,"+p%d*%d*%d",i+j+2+nagesqr-1,nbcode[Tvard[ijp][1]][codtabm(k1,j)],nbcode[Tvard[ijp][2]][codtabm(k1,j)]); */ - fprintf(ficgp,"+p%d*%d*%d",i+j+2+nagesqr-1,Tinvresult[nres][Tvard[ijp][1]],Tinvresult[nres][Tvard[ijp][2]]); - }else{ /* Vn is dummy and Vm is quanti */ - /* fprintf(ficgp,"+p%d*%d*%f",i+j+2+nagesqr-1,nbcode[Tvard[ijp][1]][codtabm(k1,j)],Tqinvresult[nres][Tvard[ijp][2]]); */ - fprintf(ficgp,"+p%d*%d*%f",i+j+2+nagesqr-1,Tinvresult[nres][Tvard[ijp][1]],Tqinvresult[nres][Tvard[ijp][2]]); + if(cptcovage >0){ /* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1, 2 V5 and V1 */ + if(j==Tage[ij]) { /* Product by age To be looked at!!*/ + if(ij <=cptcovage) { /* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1, 2 V5 and V1 */ + if(DummyV[j]==0){ + fprintf(ficgp,"+p%d*%d*x",i+j+2+nagesqr-1,Tinvresult[nres][Tvar[j]]);; + }else{ /* quantitative */ + fprintf(ficgp,"+p%d*%f*x",i+j+2+nagesqr-1,Tqinvresult[nres][Tvar[j]]); /* Tqinvresult in decoderesult */ + /* fprintf(ficgp,"+p%d*%d*x",i+j+nagesqr-1,nbcode[Tvar[j-2]][codtabm(k1,Tvar[j-2])]); */ } - }else{ /* Vn*Vm Vn is quanti */ - if(DummyV[Tvard[ijp][2]]==0){ - fprintf(ficgp,"+p%d*%d*%f",i+j+2+nagesqr-1,Tinvresult[nres][Tvard[ijp][2]],Tqinvresult[nres][Tvard[ijp][1]]); - }else{ /* Both quanti */ - fprintf(ficgp,"+p%d*%f*%f",i+j+2+nagesqr-1,Tqinvresult[nres][Tvard[ijp][1]],Tqinvresult[nres][Tvard[ijp][2]]); + ij++; + } + } + }else if(cptcovprod >0){ + if(j==Tprod[ijp]) { /* */ + /* printf("Tprod[%d]=%d, j=%d\n", ij, Tprod[ijp], j); */ + if(ijp <=cptcovprod) { /* Product */ + if(DummyV[Tvard[ijp][1]]==0){/* Vn is dummy */ + if(DummyV[Tvard[ijp][2]]==0){/* Vn and Vm are dummy */ + /* fprintf(ficgp,"+p%d*%d*%d",i+j+2+nagesqr-1,nbcode[Tvard[ijp][1]][codtabm(k1,j)],nbcode[Tvard[ijp][2]][codtabm(k1,j)]); */ + fprintf(ficgp,"+p%d*%d*%d",i+j+2+nagesqr-1,Tinvresult[nres][Tvard[ijp][1]],Tinvresult[nres][Tvard[ijp][2]]); + }else{ /* Vn is dummy and Vm is quanti */ + /* fprintf(ficgp,"+p%d*%d*%f",i+j+2+nagesqr-1,nbcode[Tvard[ijp][1]][codtabm(k1,j)],Tqinvresult[nres][Tvard[ijp][2]]); */ + fprintf(ficgp,"+p%d*%d*%f",i+j+2+nagesqr-1,Tinvresult[nres][Tvard[ijp][1]],Tqinvresult[nres][Tvard[ijp][2]]); + } + }else{ /* Vn*Vm Vn is quanti */ + if(DummyV[Tvard[ijp][2]]==0){ + fprintf(ficgp,"+p%d*%d*%f",i+j+2+nagesqr-1,Tinvresult[nres][Tvard[ijp][2]],Tqinvresult[nres][Tvard[ijp][1]]); + }else{ /* Both quanti */ + fprintf(ficgp,"+p%d*%f*%f",i+j+2+nagesqr-1,Tqinvresult[nres][Tvard[ijp][1]],Tqinvresult[nres][Tvard[ijp][2]]); + } } + ijp++; } - ijp++; - } + } /* end Tprod */ } else{ /* simple covariate */ /* fprintf(ficgp,"+p%d*%d",i+j+2+nagesqr-1,nbcode[Tvar[j]][codtabm(k1,j)]); /\* Valgrind bug nbcode *\/ */ if(Dummy[j]==0){ @@ -7481,15 +7852,16 @@ set ter svg size 640, 480\nunset log y\n ij=1; for(j=3; j <=ncovmodel-nagesqr; j++){ - if((j-2)==Tage[ij]) { /* Bug valgrind */ - if(ij <=cptcovage) { /* Bug valgrind */ - fprintf(ficgp,"+p%d*%d*x",k3+(cpt-1)*ncovmodel+1+j-2+nagesqr,nbcode[Tvar[j-2]][codtabm(k1,j-2)]); - /* fprintf(ficgp,"+p%d*%d*x",k3+(cpt-1)*ncovmodel+1+j-2+nagesqr,nbcode[Tvar[j-2]][codtabm(k1,Tvar[j-2])]); */ - ij++; - } - } - else - fprintf(ficgp,"+p%d*%d",k3+(cpt-1)*ncovmodel+1+j-2+nagesqr,nbcode[Tvar[j-2]][codtabm(k1,j-2)]);/* Valgrind bug nbcode */ + if(cptcovage >0){ + if((j-2)==Tage[ij]) { /* Bug valgrind */ + if(ij <=cptcovage) { /* Bug valgrind */ + fprintf(ficgp,"+p%d*%d*x",k3+(cpt-1)*ncovmodel+1+j-2+nagesqr,nbcode[Tvar[j-2]][codtabm(k1,j-2)]); + /* fprintf(ficgp,"+p%d*%d*x",k3+(cpt-1)*ncovmodel+1+j-2+nagesqr,nbcode[Tvar[j-2]][codtabm(k1,Tvar[j-2])]); */ + ij++; + } + } + }else + fprintf(ficgp,"+p%d*%d",k3+(cpt-1)*ncovmodel+1+j-2+nagesqr,nbcode[Tvar[j-2]][codtabm(k1,j-2)]);/* Valgrind bug nbcode */ } fprintf(ficgp,")"); } @@ -7526,10 +7898,11 @@ set ter svg size 640, 480\nunset log y\n int mobilavrange, mob; int iage=0; - double sum=0.; + double sum=0., sumr=0.; double age; - double *sumnewp, *sumnewm; - double *agemingood, *agemaxgood; /* Currently identical for all covariates */ + double *sumnewp, *sumnewm, *sumnewmr; + double *agemingood, *agemaxgood; + double *agemingoodr, *agemaxgoodr; /* modcovmax=2*cptcoveff;/\* Max number of modalities. We suppose */ @@ -7537,19 +7910,22 @@ set ter svg size 640, 480\nunset log y\n sumnewp = vector(1,ncovcombmax); sumnewm = vector(1,ncovcombmax); + sumnewmr = vector(1,ncovcombmax); agemingood = vector(1,ncovcombmax); + agemingoodr = vector(1,ncovcombmax); agemaxgood = vector(1,ncovcombmax); + agemaxgoodr = vector(1,ncovcombmax); for (cptcod=1;cptcod<=ncovcombmax;cptcod++){ - sumnewm[cptcod]=0.; + sumnewm[cptcod]=0.; sumnewmr[cptcod]=0.; sumnewp[cptcod]=0.; - agemingood[cptcod]=0; - agemaxgood[cptcod]=0; + agemingood[cptcod]=0, agemingoodr[cptcod]=0; + agemaxgood[cptcod]=0, agemaxgoodr[cptcod]=0; } if (cptcovn<1) ncovcombmax=1; /* At least 1 pass */ - if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){ - if(mobilav==1) mobilavrange=5; /* default */ + if(mobilav==-1 || mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){ + if(mobilav==1 || mobilav==-1) mobilavrange=5; /* default */ else mobilavrange=mobilav; for (age=bage; age<=fage; age++) for (i=1; i<=nlstate;i++) @@ -7561,77 +7937,143 @@ set ter svg size 640, 480\nunset log y\n */ for (mob=3;mob <=mobilavrange;mob=mob+2){ for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){ - for (i=1; i<=nlstate;i++){ - for (cptcod=1;cptcod<=ncovcombmax;cptcod++){ + for (cptcod=1;cptcod<=ncovcombmax;cptcod++){ + sumnewm[cptcod]=0.; + for (i=1; i<=nlstate;i++){ mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod]; for (cpt=1;cpt<=(mob-1)/2;cpt++){ mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod]; mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod]; } mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob; - } - } + sumnewm[cptcod]+=mobaverage[(int)age][i][cptcod]; + } /* end i */ + if(sumnewm[cptcod] >1.e-3) mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/sumnewm[cptcod]; /* Rescaling to sum one */ + } /* end cptcod */ }/* end age */ }/* end mob */ - }else + }else{ + printf("Error internal in movingaverage, mobilav=%d.\n",mobilav); return -1; - for (cptcod=1;cptcod<=ncovcombmax;cptcod++){ + } + + for (cptcod=1;cptcod<=ncovcombmax;cptcod++){ /* for each combination */ /* for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){ */ if(invalidvarcomb[cptcod]){ printf("\nCombination (%d) ignored because no cases \n",cptcod); continue; } - agemingood[cptcod]=fage-(mob-1)/2; - for (age=fage-(mob-1)/2; age>=bage; age--){/* From oldest to youngest, finding the youngest wrong */ + for (age=fage-(mob-1)/2; age>=bage+(mob-1)/2; age--){ /*looking for the youngest and oldest good age */ sumnewm[cptcod]=0.; + sumnewmr[cptcod]=0.; for (i=1; i<=nlstate;i++){ sumnewm[cptcod]+=mobaverage[(int)age][i][cptcod]; + sumnewmr[cptcod]+=probs[(int)age][i][cptcod]; + } + if(fabs(sumnewmr[cptcod] - 1.) <= 1.e-3) { /* good without smoothing */ + agemingoodr[cptcod]=age; } if(fabs(sumnewm[cptcod] - 1.) <= 1.e-3) { /* good */ - agemingood[cptcod]=age; - }else{ /* bad */ - for (i=1; i<=nlstate;i++){ - mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingood[cptcod]][i][cptcod]; - } /* i */ - } /* end bad */ - }/* age */ - sum=0.; - for (i=1; i<=nlstate;i++){ - sum+=mobaverage[(int)agemingood[cptcod]][i][cptcod]; - } - if(fabs(sum - 1.) > 1.e-3) { /* bad */ - printf("For this combination of covariate cptcod=%d, we can't get a smoothed prevalence which sums to one at any descending age!\n",cptcod); - /* for (i=1; i<=nlstate;i++){ */ - /* mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingood[cptcod]][i][cptcod]; */ - /* } /\* i *\/ */ - } /* end bad */ - /* else{ /\* We found some ages summing to one, we will smooth the oldest *\/ */ - /* From youngest, finding the oldest wrong */ - agemaxgood[cptcod]=bage+(mob-1)/2; - for (age=bage+(mob-1)/2; age<=fage; age++){ + agemingood[cptcod]=age; + } + } /* age */ + for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){ /*looking for the youngest and oldest good age */ sumnewm[cptcod]=0.; + sumnewmr[cptcod]=0.; for (i=1; i<=nlstate;i++){ sumnewm[cptcod]+=mobaverage[(int)age][i][cptcod]; + sumnewmr[cptcod]+=probs[(int)age][i][cptcod]; + } + if(fabs(sumnewmr[cptcod] - 1.) <= 1.e-3) { /* good without smoothing */ + agemaxgoodr[cptcod]=age; } if(fabs(sumnewm[cptcod] - 1.) <= 1.e-3) { /* good */ agemaxgood[cptcod]=age; - }else{ /* bad */ - for (i=1; i<=nlstate;i++){ - mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemaxgood[cptcod]][i][cptcod]; - } /* i */ + } + } /* age */ + /* Thus we have agemingood and agemaxgood as well as goodr for raw (preobs) */ + /* but they will change */ + for (age=fage-(mob-1)/2; age>=bage; age--){/* From oldest to youngest, filling up to the youngest */ + sumnewm[cptcod]=0.; + sumnewmr[cptcod]=0.; + for (i=1; i<=nlstate;i++){ + sumnewm[cptcod]+=mobaverage[(int)age][i][cptcod]; + sumnewmr[cptcod]+=probs[(int)age][i][cptcod]; + } + if(mobilav==-1){ /* Forcing raw ages if good else agemingood */ + if(fabs(sumnewmr[cptcod] - 1.) <= 1.e-3) { /* good without smoothing */ + agemaxgoodr[cptcod]=age; /* age min */ + for (i=1; i<=nlstate;i++) + mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod]; + }else{ /* bad we change the value with the values of good ages */ + for (i=1; i<=nlstate;i++){ + mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemaxgoodr[cptcod]][i][cptcod]; + } /* i */ + } /* end bad */ + }else{ + if(fabs(sumnewm[cptcod] - 1.) <= 1.e-3) { /* good */ + agemaxgood[cptcod]=age; + }else{ /* bad we change the value with the values of good ages */ + for (i=1; i<=nlstate;i++){ + mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemaxgood[cptcod]][i][cptcod]; + } /* i */ + } /* end bad */ + }/* end else */ + sum=0.;sumr=0.; + for (i=1; i<=nlstate;i++){ + sum+=mobaverage[(int)age][i][cptcod]; + sumr+=probs[(int)age][i][cptcod]; + } + if(fabs(sum - 1.) > 1.e-3) { /* bad */ + printf("Moving average A1: For this combination of covariate cptcod=%d, we can't get a smoothed prevalence which sums to one (%f) at any descending age! age=%d, could you increase bage=%d\n",cptcod,sumr, (int)age, (int)bage); + } /* end bad */ + /* else{ /\* We found some ages summing to one, we will smooth the oldest *\/ */ + if(fabs(sumr - 1.) > 1.e-3) { /* bad */ + printf("Moving average A2: For this combination of covariate cptcod=%d, the raw prevalence doesn't sums to one (%f) even with smoothed values at young ages! age=%d, could you increase bage=%d\n",cptcod,sumr, (int)age, (int)bage); } /* end bad */ }/* age */ - sum=0.; - for (i=1; i<=nlstate;i++){ - sum+=mobaverage[(int)agemaxgood[cptcod]][i][cptcod]; - } - if(fabs(sum - 1.) > 1.e-3) { /* bad */ - printf("For this combination of covariate cptcod=%d, we can't get a smoothed prevalence which sums to one at any ascending age!\n",cptcod); - /* for (i=1; i<=nlstate;i++){ */ - /* mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingood[cptcod]][i][cptcod]; */ - /* } /\* i *\/ */ - } /* end bad */ + + for (age=bage+(mob-1)/2; age<=fage; age++){/* From youngest, finding the oldest wrong */ + sumnewm[cptcod]=0.; + sumnewmr[cptcod]=0.; + for (i=1; i<=nlstate;i++){ + sumnewm[cptcod]+=mobaverage[(int)age][i][cptcod]; + sumnewmr[cptcod]+=probs[(int)age][i][cptcod]; + } + if(mobilav==-1){ /* Forcing raw ages if good else agemingood */ + if(fabs(sumnewmr[cptcod] - 1.) <= 1.e-3) { /* good */ + agemingoodr[cptcod]=age; + for (i=1; i<=nlstate;i++) + mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod]; + }else{ /* bad we change the value with the values of good ages */ + for (i=1; i<=nlstate;i++){ + mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingoodr[cptcod]][i][cptcod]; + } /* i */ + } /* end bad */ + }else{ + if(fabs(sumnewm[cptcod] - 1.) <= 1.e-3) { /* good */ + agemingood[cptcod]=age; + }else{ /* bad */ + for (i=1; i<=nlstate;i++){ + mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingood[cptcod]][i][cptcod]; + } /* i */ + } /* end bad */ + }/* end else */ + sum=0.;sumr=0.; + for (i=1; i<=nlstate;i++){ + sum+=mobaverage[(int)age][i][cptcod]; + sumr+=mobaverage[(int)age][i][cptcod]; + } + if(fabs(sum - 1.) > 1.e-3) { /* bad */ + printf("Moving average B1: For this combination of covariate cptcod=%d, we can't get a smoothed prevalence which sums to one (%f) at any descending age! age=%d, could you decrease fage=%d?\n",cptcod, sum, (int) age, (int)fage); + } /* end bad */ + /* else{ /\* We found some ages summing to one, we will smooth the oldest *\/ */ + if(fabs(sumr - 1.) > 1.e-3) { /* bad */ + printf("Moving average B2: For this combination of covariate cptcod=%d, the raw prevalence doesn't sums to one (%f) even with smoothed values at young ages! age=%d, could you increase fage=%d\n",cptcod,sumr, (int)age, (int)fage); + } /* end bad */ + }/* age */ + for (age=bage; age<=fage; age++){ /* printf("%d %d ", cptcod, (int)age); */ @@ -7646,40 +8088,44 @@ set ter svg size 640, 480\nunset log y\n } /* printf("\n"); */ /* } */ + /* brutal averaging */ - for (i=1; i<=nlstate;i++){ - for (age=1; age<=bage; age++){ - mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingood[cptcod]][i][cptcod]; - /* printf("age=%d i=%d cptcod=%d mobaverage=%.4f \n",(int)age,i, cptcod, mobaverage[(int)age][i][cptcod]); */ - } - for (age=fage; age<=AGESUP; age++){ - mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemaxgood[cptcod]][i][cptcod]; - /* printf("age=%d i=%d cptcod=%d mobaverage=%.4f \n",(int)age,i, cptcod, mobaverage[(int)age][i][cptcod]); */ - } - } /* end i status */ - for (i=nlstate+1; i<=nlstate+ndeath;i++){ - for (age=1; age<=AGESUP; age++){ - /*printf("i=%d, age=%d, cptcod=%d\n",i, (int)age, cptcod);*/ - mobaverage[(int)age][i][cptcod]=0.; - } - } + /* for (i=1; i<=nlstate;i++){ */ + /* for (age=1; age<=bage; age++){ */ + /* mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemingood[cptcod]][i][cptcod]; */ + /* /\* printf("age=%d i=%d cptcod=%d mobaverage=%.4f \n",(int)age,i, cptcod, mobaverage[(int)age][i][cptcod]); *\/ */ + /* } */ + /* for (age=fage; age<=AGESUP; age++){ */ + /* mobaverage[(int)age][i][cptcod]=mobaverage[(int)agemaxgood[cptcod]][i][cptcod]; */ + /* /\* printf("age=%d i=%d cptcod=%d mobaverage=%.4f \n",(int)age,i, cptcod, mobaverage[(int)age][i][cptcod]); *\/ */ + /* } */ + /* } /\* end i status *\/ */ + /* for (i=nlstate+1; i<=nlstate+ndeath;i++){ */ + /* for (age=1; age<=AGESUP; age++){ */ + /* /\*printf("i=%d, age=%d, cptcod=%d\n",i, (int)age, cptcod);*\/ */ + /* mobaverage[(int)age][i][cptcod]=0.; */ + /* } */ + /* } */ }/* end cptcod */ - free_vector(sumnewm,1, ncovcombmax); - free_vector(sumnewp,1, ncovcombmax); + free_vector(agemaxgoodr,1, ncovcombmax); free_vector(agemaxgood,1, ncovcombmax); free_vector(agemingood,1, ncovcombmax); + free_vector(agemingoodr,1, ncovcombmax); + free_vector(sumnewmr,1, ncovcombmax); + free_vector(sumnewm,1, ncovcombmax); + free_vector(sumnewp,1, ncovcombmax); return 0; }/* End movingaverage */ /************** Forecasting ******************/ - void prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){ + void prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double ***prev, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){ /* proj1, year, month, day of starting projection agemin, agemax range of age dateprev1 dateprev2 range of dates during which prevalence is computed anproj2 year of en of projection (same day and month as proj1). */ - int yearp, stepsize, hstepm, nhstepm, j, k, cptcod, i, h, i1, k4, nres=0; + int yearp, stepsize, hstepm, nhstepm, j, k, cptcod, i, h, i1, k4, nres=0; double agec; /* generic age */ double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean; double *popeffectif,*popcount; @@ -7712,7 +8158,12 @@ set ter svg size 640, 480\nunset log y\n if(estepm < stepm){ printf ("Problem %d lower than %d\n",estepm, stepm); } - else hstepm=estepm; + else{ + hstepm=estepm; + } + if(estepm > stepm){ /* Yes every two year */ + stepsize=2; + } hstepm=hstepm/stepm; yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp and @@ -7757,39 +8208,41 @@ set ter svg size 640, 480\nunset log y\n for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { fprintf(ficresf,"\n"); fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp); - for (agec=fage; agec>=(ageminpar-1); agec--){ + /* for (agec=fage; agec>=(ageminpar-1); agec--){ */ + for (agec=fage; agec>=(bage); agec--){ nhstepm=(int) rint((agelim-agec)*YEARM/stepm); nhstepm = nhstepm/hstepm; p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); oldm=oldms;savm=savms; + /* We compute pii at age agec over nhstepm);*/ hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k,nres); - + /* Then we print p3mat for h corresponding to the right agec+h*stepms=yearp */ for (h=0; h<=nhstepm; h++){ if (h*hstepm/YEARM*stepm ==yearp) { - fprintf(ficresf,"\n"); - for(j=1;j<=cptcoveff;j++) - fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); - fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm); - } - for(j=1; j<=nlstate+ndeath;j++) { - ppij=0.; - for(i=1; i<=nlstate;i++) { - if (mobilav==1) - ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][k]; - else { - ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][k]; - } - if (h*hstepm/YEARM*stepm== yearp) { - fprintf(ficresf," %.3f", p3mat[i][j][h]); - } - } /* end i */ - if (h*hstepm/YEARM*stepm==yearp) { - fprintf(ficresf," %.3f", ppij); - } - }/* end j */ - } /* end h */ + break; + } + } + fprintf(ficresf,"\n"); + for(j=1;j<=cptcoveff;j++) + fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm); + + for(j=1; j<=nlstate+ndeath;j++) { + ppij=0.; + for(i=1; i<=nlstate;i++) { + /* if (mobilav>=1) */ + ppij=ppij+p3mat[i][j][h]*prev[(int)agec][i][k]; + /* else { */ /* even if mobilav==-1 we use mobaverage */ + /* ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][k]; */ + /* } */ + fprintf(ficresf," %.3f", p3mat[i][j][h]); + } /* end i */ + fprintf(ficresf," %.3f", ppij); + }/* end j */ free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); } /* end agec */ + /* diffyear=(int) anproj1+yearp-ageminpar-1; */ + /*printf("Prevforecast %d+%d-%d=diffyear=%d\n",(int) anproj1, (int)yearp,(int)ageminpar,(int) anproj1-(int)ageminpar);*/ } /* end yearp */ } /* end k */ @@ -7799,135 +8252,273 @@ set ter svg size 640, 480\nunset log y\n } -/* /\************** Back Forecasting ******************\/ */ -/* void prevbackforecast(char fileres[], double anback1, double mback1, double jback1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anback2, double p[], int cptcoveff){ */ -/* /\* back1, year, month, day of starting backection */ -/* agemin, agemax range of age */ -/* dateprev1 dateprev2 range of dates during which prevalence is computed */ -/* anback2 year of en of backection (same day and month as back1). */ -/* *\/ */ -/* int yearp, stepsize, hstepm, nhstepm, j, k, cptcod, i, h, i1; */ -/* double agec; /\* generic age *\/ */ -/* double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean; */ -/* double *popeffectif,*popcount; */ -/* double ***p3mat; */ -/* /\* double ***mobaverage; *\/ */ -/* char fileresfb[FILENAMELENGTH]; */ - -/* agelim=AGESUP; */ -/* /\* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people */ -/* in each health status at the date of interview (if between dateprev1 and dateprev2). */ -/* We still use firstpass and lastpass as another selection. */ -/* *\/ */ -/* /\* freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart,\ *\/ */ -/* /\* firstpass, lastpass, stepm, weightopt, model); *\/ */ -/* prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass); */ - -/* strcpy(fileresfb,"FB_"); */ -/* strcat(fileresfb,fileresu); */ -/* if((ficresfb=fopen(fileresfb,"w"))==NULL) { */ -/* printf("Problem with back forecast resultfile: %s\n", fileresfb); */ -/* fprintf(ficlog,"Problem with back forecast resultfile: %s\n", fileresfb); */ -/* } */ -/* printf("Computing back forecasting: result on file '%s', please wait... \n", fileresfb); */ -/* fprintf(ficlog,"Computing back forecasting: result on file '%s', please wait... \n", fileresfb); */ - -/* if (cptcoveff==0) ncodemax[cptcoveff]=1; */ - -/* /\* if (mobilav!=0) { *\/ */ -/* /\* mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX); *\/ */ -/* /\* if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){ *\/ */ -/* /\* fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav); *\/ */ -/* /\* printf(" Error in movingaverage mobilav=%d\n",mobilav); *\/ */ -/* /\* } *\/ */ -/* /\* } *\/ */ - -/* stepsize=(int) (stepm+YEARM-1)/YEARM; */ -/* if (stepm<=12) stepsize=1; */ -/* if(estepm < stepm){ */ -/* printf ("Problem %d lower than %d\n",estepm, stepm); */ -/* } */ -/* else hstepm=estepm; */ - -/* hstepm=hstepm/stepm; */ -/* yp1=modf(dateintmean,&yp);/\* extracts integral of datemean in yp and */ -/* fractional in yp1 *\/ */ -/* anprojmean=yp; */ -/* yp2=modf((yp1*12),&yp); */ -/* mprojmean=yp; */ -/* yp1=modf((yp2*30.5),&yp); */ -/* jprojmean=yp; */ -/* if(jprojmean==0) jprojmean=1; */ -/* if(mprojmean==0) jprojmean=1; */ - -/* i1=cptcoveff; */ -/* if (cptcovn < 1){i1=1;} */ +/************** Back Forecasting ******************/ + void prevbackforecast(char fileres[], double ***prevacurrent, double anback1, double mback1, double jback1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anback2, double p[], int cptcoveff){ + /* back1, year, month, day of starting backection + agemin, agemax range of age + dateprev1 dateprev2 range of dates during which prevalence is computed + anback2 year of end of backprojection (same day and month as back1). + prevacurrent and prev are prevalences. + */ + int yearp, stepsize, hstepm, nhstepm, j, k, cptcod, i, h, i1, k4, nres=0; + double agec; /* generic age */ + double agelim, ppij, ppi, yp,yp1,yp2,jprojmean,mprojmean,anprojmean; + double *popeffectif,*popcount; + double ***p3mat; + /* double ***mobaverage; */ + char fileresfb[FILENAMELENGTH]; + + agelim=AGEINF; + /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people + in each health status at the date of interview (if between dateprev1 and dateprev2). + We still use firstpass and lastpass as another selection. + */ + /* freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart,\ */ + /* firstpass, lastpass, stepm, weightopt, model); */ + + /*Do we need to compute prevalence again?*/ + + /* prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass); */ -/* fprintf(ficresfb,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); */ + strcpy(fileresfb,"FB_"); + strcat(fileresfb,fileresu); + if((ficresfb=fopen(fileresfb,"w"))==NULL) { + printf("Problem with back forecast resultfile: %s\n", fileresfb); + fprintf(ficlog,"Problem with back forecast resultfile: %s\n", fileresfb); + } + printf("\nComputing back forecasting: result on file '%s', please wait... \n", fileresfb); + fprintf(ficlog,"\nComputing back forecasting: result on file '%s', please wait... \n", fileresfb); -/* fprintf(ficresfb,"#****** Routine prevbackforecast **\n"); */ - -/* /\* if (h==(int)(YEARM*yearp)){ *\/ */ -/* for(cptcov=1, k=0;cptcov<=i1;cptcov++){ */ -/* for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){ */ -/* k=k+1; */ -/* fprintf(ficresfb,"\n#****** hbijx=probability over h years, hp.jx is weighted by observed prev \n#"); */ -/* for(j=1;j<=cptcoveff;j++) { */ -/* fprintf(ficresfb," V%d (=) %d",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); */ -/* } */ -/* fprintf(ficresfb," yearbproj age"); */ -/* for(j=1; j<=nlstate+ndeath;j++){ */ -/* for(i=1; i<=nlstate;i++) */ -/* fprintf(ficresfb," p%d%d",i,j); */ -/* fprintf(ficresfb," p.%d",j); */ -/* } */ -/* for (yearp=0; yearp>=(anback2-anback1);yearp -=stepsize) { */ -/* /\* for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { *\/ */ -/* fprintf(ficresfb,"\n"); */ -/* fprintf(ficresfb,"\n# Back Forecasting at date %.lf/%.lf/%.lf ",jback1,mback1,anback1+yearp); */ -/* for (agec=fage; agec>=(ageminpar-1); agec--){ */ -/* nhstepm=(int) rint((agelim-agec)*YEARM/stepm); */ -/* nhstepm = nhstepm/hstepm; */ -/* p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); */ -/* oldm=oldms;savm=savms; */ -/* hbxij(p3mat,nhstepm,agec,hstepm,p,prevacurrent,nlstate,stepm,oldm,savm,oldm,savm, dnewm, doldm, dsavm, k); */ -/* for (h=0; h<=nhstepm; h++){ */ -/* if (h*hstepm/YEARM*stepm ==yearp) { */ -/* fprintf(ficresfb,"\n"); */ -/* for(j=1;j<=cptcoveff;j++) */ -/* fprintf(ficresfb,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); */ -/* fprintf(ficresfb,"%.f %.f ",anback1+yearp,agec+h*hstepm/YEARM*stepm); */ -/* } */ -/* for(j=1; j<=nlstate+ndeath;j++) { */ -/* ppij=0.; */ -/* for(i=1; i<=nlstate;i++) { */ -/* if (mobilav==1) */ -/* ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod]; */ -/* else { */ -/* ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod]; */ -/* } */ -/* if (h*hstepm/YEARM*stepm== yearp) { */ -/* fprintf(ficresfb," %.3f", p3mat[i][j][h]); */ -/* } */ -/* } /\* end i *\/ */ -/* if (h*hstepm/YEARM*stepm==yearp) { */ -/* fprintf(ficresfb," %.3f", ppij); */ -/* } */ -/* }/\* end j *\/ */ -/* } /\* end h *\/ */ -/* free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); */ -/* } /\* end agec *\/ */ -/* } /\* end yearp *\/ */ -/* } /\* end cptcod *\/ */ -/* } /\* end cptcov *\/ */ - -/* /\* if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX); *\/ */ - -/* fclose(ficresfb); */ -/* printf("End of Computing Back forecasting \n"); */ -/* fprintf(ficlog,"End of Computing Back forecasting\n"); */ + if (cptcoveff==0) ncodemax[cptcoveff]=1; + + + stepsize=(int) (stepm+YEARM-1)/YEARM; + if (stepm<=12) stepsize=1; + if(estepm < stepm){ + printf ("Problem %d lower than %d\n",estepm, stepm); + } + else{ + hstepm=estepm; + } + if(estepm >= stepm){ /* Yes every two year */ + stepsize=2; + } + + hstepm=hstepm/stepm; + yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp and + fractional in yp1 */ + anprojmean=yp; + yp2=modf((yp1*12),&yp); + mprojmean=yp; + yp1=modf((yp2*30.5),&yp); + jprojmean=yp; + if(jprojmean==0) jprojmean=1; + if(mprojmean==0) jprojmean=1; + + i1=pow(2,cptcoveff); + if (cptcovn < 1){i1=1;} + + fprintf(ficresfb,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); + printf("# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); + + fprintf(ficresfb,"#****** Routine prevbackforecast **\n"); + + for(nres=1; nres <= nresult; nres++) /* For each resultline */ + for(k=1; k<=i1;k++){ + if(i1 != 1 && TKresult[nres]!= k) + continue; + if(invalidvarcomb[k]){ + printf("\nCombination (%d) projection ignored because no cases \n",k); + continue; + } + fprintf(ficresfb,"\n#****** hbijx=probability over h years, hb.jx is weighted by observed prev \n#"); + for(j=1;j<=cptcoveff;j++) { + fprintf(ficresfb," V%d (=) %d",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + } + for (k4=1; k4<= nsq; k4++){ /* For each selected (single) quantitative value */ + fprintf(ficresf," V%d=%f ",Tvqresult[nres][k4],Tqresult[nres][k4]); + } + fprintf(ficresfb," yearbproj age"); + for(j=1; j<=nlstate+ndeath;j++){ + for(i=1; i<=nlstate;i++) + fprintf(ficresfb," b%d%d",i,j); + fprintf(ficresfb," b.%d",j); + } + for (yearp=0; yearp>=(anback2-anback1);yearp -=stepsize) { + /* for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { */ + fprintf(ficresfb,"\n"); + fprintf(ficresfb,"\n# Back Forecasting at date %.lf/%.lf/%.lf ",jback1,mback1,anback1+yearp); + printf("\n# Back Forecasting at date %.lf/%.lf/%.lf ",jback1,mback1,anback1+yearp); + /* for (agec=bage; agec<=agemax-1; agec++){ /\* testing *\/ */ + for (agec=bage; agec<=fage; agec++){ /* testing */ + /* We compute bij at age agec over nhstepm, nhstepm decreases when agec increases because of agemax;*/ + nhstepm=(int) (agec-agelim) *YEARM/stepm;/* nhstepm=(int) rint((agec-agelim)*YEARM/stepm);*/ + nhstepm = nhstepm/hstepm; + p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); + oldm=oldms;savm=savms; + /* computes hbxij at age agec over 1 to nhstepm */ + /* printf("####prevbackforecast debug agec=%.2f nhstepm=%d\n",agec, nhstepm);fflush(stdout); */ + hbxij(p3mat,nhstepm,agec,hstepm,p,prevacurrent,nlstate,stepm, k, nres); + /* hpxij(p3mat,nhstepm,agec,hstepm,p, nlstate,stepm,oldm,savm, k,nres); */ + /* Then we print p3mat for h corresponding to the right agec+h*stepms=yearp */ + /* printf(" agec=%.2f\n",agec);fflush(stdout); */ + for (h=0; h<=nhstepm; h++){ + if (h*hstepm/YEARM*stepm ==-yearp) { + break; + } + } + fprintf(ficresfb,"\n"); + for(j=1;j<=cptcoveff;j++) + fprintf(ficresfb,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + fprintf(ficresfb,"%.f %.f ",anback1+yearp,agec-h*hstepm/YEARM*stepm); + for(i=1; i<=nlstate+ndeath;i++) { + ppij=0.;ppi=0.; + for(j=1; j<=nlstate;j++) { + /* if (mobilav==1) */ + ppij=ppij+p3mat[i][j][h]*prevacurrent[(int)agec][j][k]; + ppi=ppi+prevacurrent[(int)agec][j][k]; + /* ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][j][k]; */ + /* ppi=ppi+mobaverage[(int)agec][j][k]; */ + /* else { */ + /* ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][k]; */ + /* } */ + fprintf(ficresfb," %.3f", p3mat[i][j][h]); + } /* end j */ + if(ppi <0.99){ + printf("Error in prevbackforecast, prevalence doesn't sum to 1 for state %d: %3f\n",i, ppi); + fprintf(ficlog,"Error in prevbackforecast, prevalence doesn't sum to 1 for state %d: %3f\n",i, ppi); + } + fprintf(ficresfb," %.3f", ppij); + }/* end j */ + free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); + } /* end agec */ + } /* end yearp */ + } /* end k */ + + /* if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX); */ + + fclose(ficresfb); + printf("End of Computing Back forecasting \n"); + fprintf(ficlog,"End of Computing Back forecasting\n"); -/* } */ +} + +/* Variance of prevalence limit: varprlim */ + void varprlim(char fileresu[], int nresult, double ***prevacurrent, int mobilavproj, double bage, double fage, double **prlim, int *ncvyearp, double ftolpl, double p[], double **matcov, double *delti, int stepm, int cptcoveff){ + /*------- Variance of period (stable) prevalence------*/ + + char fileresvpl[FILENAMELENGTH]; + FILE *ficresvpl; + double **oldm, **savm; + double **varpl; /* Variances of prevalence limits by age */ + int i1, k, nres, j ; + + strcpy(fileresvpl,"VPL_"); + strcat(fileresvpl,fileresu); + if((ficresvpl=fopen(fileresvpl,"w"))==NULL) { + printf("Problem with variance of period (stable) prevalence resultfile: %s\n", fileresvpl); + exit(0); + } + printf("Computing Variance-covariance of period (stable) prevalence: file '%s' ...", fileresvpl);fflush(stdout); + fprintf(ficlog, "Computing Variance-covariance of period (stable) prevalence: file '%s' ...", fileresvpl);fflush(ficlog); + + /*for(cptcov=1,k=0;cptcov<=i1;cptcov++){ + for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){*/ + + i1=pow(2,cptcoveff); + if (cptcovn < 1){i1=1;} + + for(nres=1; nres <= nresult; nres++) /* For each resultline */ + for(k=1; k<=i1;k++){ + if(i1 != 1 && TKresult[nres]!= k) + continue; + fprintf(ficresvpl,"\n#****** "); + printf("\n#****** "); + fprintf(ficlog,"\n#****** "); + for(j=1;j<=cptcoveff;j++) { + fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + fprintf(ficlog,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + printf("V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + } + for (j=1; j<= nsq; j++){ /* For each selected (single) quantitative value */ + printf(" V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); + fprintf(ficresvpl," V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); + fprintf(ficlog," V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); + } + fprintf(ficresvpl,"******\n"); + printf("******\n"); + fprintf(ficlog,"******\n"); + + varpl=matrix(1,nlstate,(int) bage, (int) fage); + oldm=oldms;savm=savms; + varprevlim(fileresvpl, ficresvpl, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl, ncvyearp, k, strstart, nres); + free_matrix(varpl,1,nlstate,(int) bage, (int)fage); + /*}*/ + } + + fclose(ficresvpl); + printf("done variance-covariance of period prevalence\n");fflush(stdout); + fprintf(ficlog,"done variance-covariance of period prevalence\n");fflush(ficlog); + + } +/* Variance of back prevalence: varbprlim */ + void varbprlim(char fileresu[], int nresult, double ***prevacurrent, int mobilavproj, double bage, double fage, double **bprlim, int *ncvyearp, double ftolpl, double p[], double **matcov, double *delti, int stepm, int cptcoveff){ + /*------- Variance of back (stable) prevalence------*/ + + char fileresvbl[FILENAMELENGTH]; + FILE *ficresvbl; + + double **oldm, **savm; + double **varbpl; /* Variances of back prevalence limits by age */ + int i1, k, nres, j ; + + strcpy(fileresvbl,"VBL_"); + strcat(fileresvbl,fileresu); + if((ficresvbl=fopen(fileresvbl,"w"))==NULL) { + printf("Problem with variance of back (stable) prevalence resultfile: %s\n", fileresvbl); + exit(0); + } + printf("Computing Variance-covariance of back (stable) prevalence: file '%s' ...", fileresvbl);fflush(stdout); + fprintf(ficlog, "Computing Variance-covariance of back (stable) prevalence: file '%s' ...", fileresvbl);fflush(ficlog); + + + i1=pow(2,cptcoveff); + if (cptcovn < 1){i1=1;} + + for(nres=1; nres <= nresult; nres++) /* For each resultline */ + for(k=1; k<=i1;k++){ + if(i1 != 1 && TKresult[nres]!= k) + continue; + fprintf(ficresvbl,"\n#****** "); + printf("\n#****** "); + fprintf(ficlog,"\n#****** "); + for(j=1;j<=cptcoveff;j++) { + fprintf(ficresvbl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + fprintf(ficlog,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + printf("V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); + } + for (j=1; j<= nsq; j++){ /* For each selected (single) quantitative value */ + printf(" V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); + fprintf(ficresvbl," V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); + fprintf(ficlog," V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); + } + fprintf(ficresvbl,"******\n"); + printf("******\n"); + fprintf(ficlog,"******\n"); + + varbpl=matrix(1,nlstate,(int) bage, (int) fage); + oldm=oldms;savm=savms; + + varbrevlim(fileresvbl, ficresvbl, varbpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, bprlim, ftolpl, mobilavproj, ncvyearp, k, strstart, nres); + free_matrix(varbpl,1,nlstate,(int) bage, (int)fage); + /*}*/ + } + + fclose(ficresvbl); + printf("done variance-covariance of back prevalence\n");fflush(stdout); + fprintf(ficlog,"done variance-covariance of back prevalence\n");fflush(ficlog); + + } /* End of varbprlim */ /************** Forecasting *****not tested NB*************/ /* void populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2s, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){ */ @@ -9771,6 +10362,8 @@ int back_prevalence_limit(double *p, dou }else{ /* bprevalim(bprlim, probs, nlstate, p, age, oldm, savm, dnewm, doldm, dsavm, ftolpl, ncvyearp, k); */ bprevalim(bprlim, probs, nlstate, p, age, ftolpl, ncvyearp, k,nres); + /* printf("TOTOT\n"); */ + /* exit(1); */ } fprintf(ficresplb,"%.0f ",age ); for(j=1;j<=cptcoveff;j++) @@ -9929,10 +10522,12 @@ int hPijx(double *p, int bage, int fage) /* nhstepm=nhstepm*YEARM; aff par mois*/ - p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); + p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm); /* We can't have it at an upper level because of nhstepm */ + /* and memory limitations if stepm is small */ + /* oldm=oldms;savm=savms; */ /* hbxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k); */ - hbxij(p3mat,nhstepm,agedeb,hstepm,p,prevacurrent,nlstate,stepm, k); + hbxij(p3mat,nhstepm,agedeb,hstepm,p,prevacurrent,nlstate,stepm, k, nres); /* hbxij(p3mat,nhstepm,agedeb,hstepm,p,prevacurrent,nlstate,stepm,oldm,savm, dnewm, doldm, dsavm, k); */ fprintf(ficrespijb,"# Cov Agex agex-h hbijx with i,j="); for(i=1; i<=nlstate;i++) @@ -10033,6 +10628,7 @@ int main(int argc, char *argv[]) double *delti; /* Scale */ double ***eij, ***vareij; double **varpl; /* Variances of prevalence limits by age */ + double *epj, vepp; double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000; @@ -10316,9 +10912,9 @@ int main(int argc, char *argv[]) covar=matrix(0,NCOVMAX,1,n); /**< used in readdata */ - coqvar=matrix(1,nqv,1,n); /**< Fixed quantitative covariate */ - cotvar=ma3x(1,maxwav,1,ntv+nqtv,1,n); /**< Time varying covariate (dummy and quantitative)*/ - cotqvar=ma3x(1,maxwav,1,nqtv,1,n); /**< Time varying quantitative covariate */ + if(nqv>=1)coqvar=matrix(1,nqv,1,n); /**< Fixed quantitative covariate */ + if(nqtv>=1)cotqvar=ma3x(1,maxwav,1,nqtv,1,n); /**< Time varying quantitative covariate */ + if(ntv+nqtv>=1)cotvar=ma3x(1,maxwav,1,ntv+nqtv,1,n); /**< Time varying covariate (dummy and quantitative)*/ cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement plus one, indepently of n in Vn*/ /* v1+v2+v3+v2*v4+v5*age makes cptcovn = 5 v1+v2*age+v2*v3 makes cptcovn = 3 @@ -10869,10 +11465,10 @@ Youngest age at first (selected) pass %. Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf
    \n",\ imx,agemin,agemax,jmin,jmax,jmean); pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ - oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ - newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ - savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ - oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */ + oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ + newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ + savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */ + oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */ /* For Powell, parameters are in a vector p[] starting at p[1] so we point p on param[1][1] so that p[1] maps on param[1][1][1] */ @@ -11492,7 +12088,8 @@ Please run with mle=-1 to get a correct This is probably because your parameter file doesn't \n contain the exact number of lines (or columns) corresponding to your model line.\n\ Please run with mle=-1 to get a correct covariance matrix.\n",ageminpar,agemaxpar); }else{ - printinggnuplot(fileresu, optionfilefiname,ageminpar,agemaxpar,fage, prevfcast, backcast, pathc,p); + /* printinggnuplot(fileresu, optionfilefiname,ageminpar,agemaxpar,fage, prevfcast, backcast, pathc,p, (int)anproj1-(int)agemin, (int)anback1-(int)agemax+1); */ + printinggnuplot(fileresu, optionfilefiname,ageminpar,agemaxpar,bage, fage, prevfcast, backcast, pathc,p, (int)anproj1-bage, (int)anback1-fage); } printinghtml(fileresu,title,datafile, firstpass, lastpass, stepm, weightopt, \ model,imx,jmin,jmax,jmean,rfileres,popforecast,mobilav,prevfcast,mobilavproj,backcast, estepm, \ @@ -11532,17 +12129,18 @@ Please run with mle=-1 to get a correct k=1; varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax,strstart); - /* Prevalence for each covariates in probs[age][status][cov] */ - probs= ma3x(1,AGESUP,1,nlstate+ndeath, 1,ncovcombmax); - for(i=1;i<=AGESUP;i++) + /* Prevalence for each covariate combination in probs[age][status][cov] */ + probs= ma3x(AGEINF,AGESUP,1,nlstate+ndeath, 1,ncovcombmax); + for(i=AGEINF;i<=AGESUP;i++) for(j=1;j<=nlstate+ndeath;j++) /* ndeath is useless but a necessity to be compared with mobaverages */ for(k=1;k<=ncovcombmax;k++) probs[i][j][k]=0.; - prevalence(probs, ageminpar, agemaxpar, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass); + prevalence(probs, ageminpar, agemaxpar, s, agev, nlstate, imx, Tvar, nbcode, + ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass); if (mobilav!=0 ||mobilavproj !=0 ) { - mobaverages= ma3x(1, AGESUP,1,nlstate+ndeath, 1,ncovcombmax); - for(i=1;i<=AGESUP;i++) - for(j=1;j<=nlstate;j++) + mobaverages= ma3x(AGEINF, AGESUP,1,nlstate+ndeath, 1,ncovcombmax); + for(i=AGEINF;i<=AGESUP;i++) + for(j=1;j<=nlstate+ndeath;j++) for(k=1;k<=ncovcombmax;k++) mobaverages[i][j][k]=0.; mobaverage=mobaverages; @@ -11553,25 +12151,27 @@ Please run with mle=-1 to get a correct fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav); printf(" Error in movingaverage mobilav=%d\n",mobilav); } - } - /* /\* Prevalence for each covariates in probs[age][status][cov] *\/ */ - /* prevalence(probs, ageminpar, agemaxpar, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass); */ - else if (mobilavproj !=0) { + } else if (mobilavproj !=0) { printf("Movingaveraging projected observed prevalence\n"); fprintf(ficlog,"Movingaveraging projected observed prevalence\n"); if (movingaverage(probs, ageminpar, agemaxpar, mobaverage, mobilavproj)!=0){ fprintf(ficlog," Error in movingaverage mobilavproj=%d\n",mobilavproj); printf(" Error in movingaverage mobilavproj=%d\n",mobilavproj); } + }else{ + printf("Internal error moving average\n"); + fflush(stdout); + exit(1); } }/* end if moving average */ /*---------- Forecasting ------------------*/ - /*if((stepm == 1) && (strcmp(model,".")==0)){*/ if(prevfcast==1){ /* if(stepm ==1){*/ - prevforecast(fileresu, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff); + prevforecast(fileresu, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, mobaverage, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff); } + + /* Backcasting */ if(backcast==1){ ddnewms=matrix(1,nlstate+ndeath,1,nlstate+ndeath); ddoldms=matrix(1,nlstate+ndeath,1,nlstate+ndeath); @@ -11580,20 +12180,24 @@ Please run with mle=-1 to get a correct /*--------------- Back Prevalence limit (period or stable prevalence) --------------*/ bprlim=matrix(1,nlstate,1,nlstate); + back_prevalence_limit(p, bprlim, ageminpar, agemaxpar, ftolpl, &ncvyear, dateprev1, dateprev2, firstpass, lastpass, mobilavproj); fclose(ficresplb); hBijx(p, bage, fage, mobaverage); fclose(ficrespijb); - free_matrix(bprlim,1,nlstate,1,nlstate); /*here or after loop ? */ - /* prevbackforecast(fileresu, anback1, mback1, jback1, agemin, agemax, dateprev1, dateprev2, mobilavproj, - bage, fage, firstpass, lastpass, anback2, p, cptcoveff); */ + prevbackforecast(fileresu, mobaverage, anback1, mback1, jback1, agemin, agemax, dateprev1, dateprev2, + mobilavproj, bage, fage, firstpass, lastpass, anback2, p, cptcoveff); + varbprlim(fileresu, nresult, mobaverage, mobilavproj, bage, fage, bprlim, &ncvyear, ftolpl, p, matcov, delti, stepm, cptcoveff); + + + free_matrix(bprlim,1,nlstate,1,nlstate); /*here or after loop ? */ free_matrix(ddnewms, 1, nlstate+ndeath, 1, nlstate+ndeath); free_matrix(ddsavms, 1, nlstate+ndeath, 1, nlstate+ndeath); free_matrix(ddoldms, 1, nlstate+ndeath, 1, nlstate+ndeath); - } - + } /* end Backcasting */ + /* ------ Other prevalence ratios------------ */ @@ -11645,10 +12249,10 @@ Please run with mle=-1 to get a correct fclose(ficreseij); printf("done evsij\n");fflush(stdout); fprintf(ficlog,"done evsij\n");fflush(ficlog); + /*---------- State-specific expectancies and variances ------------*/ - strcpy(filerest,"T_"); strcat(filerest,fileresu); if((ficrest=fopen(filerest,"w"))==NULL) { @@ -11657,8 +12261,6 @@ Please run with mle=-1 to get a correct } printf("Computing Total Life expectancies with their standard errors: file '%s' ...\n", filerest); fflush(stdout); fprintf(ficlog,"Computing Total Life expectancies with their standard errors: file '%s' ...\n", filerest); fflush(ficlog); - - strcpy(fileresstde,"STDE_"); strcat(fileresstde,fileresu); if((ficresstdeij=fopen(fileresstde,"w"))==NULL) { @@ -11686,9 +12288,6 @@ Please run with mle=-1 to get a correct printf(" Computing Variance-covariance of State-specific Expectancies: file '%s' ... ", fileresv);fflush(stdout); fprintf(ficlog," Computing Variance-covariance of State-specific Expectancies: file '%s' ... ", fileresv);fflush(ficlog); - /*for(cptcov=1,k=0;cptcov<=i1;cptcov++){ - for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){*/ - i1=pow(2,cptcoveff); /* Number of combination of dummy covariates */ if (cptcovn < 1){i1=1;} @@ -11750,7 +12349,7 @@ Please run with mle=-1 to get a correct vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage); pstamp(ficrest); - + epj=vector(1,nlstate+1); for(vpopbased=0; vpopbased <= popbased; vpopbased++){ /* Done for vpopbased=0 and vpopbased=1 if popbased==1*/ oldm=oldms;savm=savms; /* ZZ Segmentation fault */ cptcod= 0; /* To be deleted */ @@ -11766,7 +12365,6 @@ Please run with mle=-1 to get a correct for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i); fprintf(ficrest,"\n"); /* printf("Which p?\n"); for(i=1;i<=npar;i++)printf("p[i=%d]=%lf,",i,p[i]);printf("\n"); */ - epj=vector(1,nlstate+1); printf("Computing age specific period (stable) prevalences in each health state \n"); fprintf(ficlog,"Computing age specific period (stable) prevalences in each health state \n"); for(age=bage; age <=fage ;age++){ @@ -11804,66 +12402,20 @@ Please run with mle=-1 to get a correct fprintf(ficrest,"\n"); } } /* End vpopbased */ + free_vector(epj,1,nlstate+1); free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage); free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage); - free_vector(epj,1,nlstate+1); printf("done selection\n");fflush(stdout); fprintf(ficlog,"done selection\n");fflush(ficlog); - /*}*/ } /* End k selection */ printf("done State-specific expectancies\n");fflush(stdout); fprintf(ficlog,"done State-specific expectancies\n");fflush(ficlog); - /*------- Variance of period (stable) prevalence------*/ - - strcpy(fileresvpl,"VPL_"); - strcat(fileresvpl,fileresu); - if((ficresvpl=fopen(fileresvpl,"w"))==NULL) { - printf("Problem with variance of period (stable) prevalence resultfile: %s\n", fileresvpl); - exit(0); - } - printf("Computing Variance-covariance of period (stable) prevalence: file '%s' ...", fileresvpl);fflush(stdout); - fprintf(ficlog, "Computing Variance-covariance of period (stable) prevalence: file '%s' ...", fileresvpl);fflush(ficlog); - - /*for(cptcov=1,k=0;cptcov<=i1;cptcov++){ - for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){*/ - - i1=pow(2,cptcoveff); - if (cptcovn < 1){i1=1;} + /* variance-covariance of period prevalence*/ + varprlim(fileresu, nresult, mobaverage, mobilavproj, bage, fage, prlim, &ncvyear, ftolpl, p, matcov, delti, stepm, cptcoveff); - for(nres=1; nres <= nresult; nres++) /* For each resultline */ - for(k=1; k<=i1;k++){ - if(i1 != 1 && TKresult[nres]!= k) - continue; - fprintf(ficresvpl,"\n#****** "); - printf("\n#****** "); - fprintf(ficlog,"\n#****** "); - for(j=1;j<=cptcoveff;j++) { - fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); - fprintf(ficlog,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); - printf("V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtabm(k,j)]); - } - for (j=1; j<= nsq; j++){ /* For each selected (single) quantitative value */ - printf(" V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); - fprintf(ficresvpl," V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); - fprintf(ficlog," V%d=%f ",Tvqresult[nres][j],Tqresult[nres][j]); - } - fprintf(ficresvpl,"******\n"); - printf("******\n"); - fprintf(ficlog,"******\n"); - - varpl=matrix(1,nlstate,(int) bage, (int) fage); - oldm=oldms;savm=savms; - varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl, &ncvyear, k, strstart, nres); - free_matrix(varpl,1,nlstate,(int) bage, (int)fage); - /*}*/ - } - - fclose(ficresvpl); - printf("done variance-covariance of period prevalence\n");fflush(stdout); - fprintf(ficlog,"done variance-covariance of period prevalence\n");fflush(ficlog); free_vector(weight,1,n); free_imatrix(Tvard,1,NCOVMAX,1,2); @@ -11881,8 +12433,8 @@ Please run with mle=-1 to get a correct /*---------- End : free ----------------*/ if (mobilav!=0 ||mobilavproj !=0) - free_ma3x(mobaverages,1, AGESUP,1,nlstate+ndeath, 1,ncovcombmax); /* We need to have a squared matrix with prevalence of the dead! */ - free_ma3x(probs,1,AGESUP,1,nlstate+ndeath, 1,ncovcombmax); + free_ma3x(mobaverages,AGEINF, AGESUP,1,nlstate+ndeath, 1,ncovcombmax); /* We need to have a squared matrix with prevalence of the dead! */ + free_ma3x(probs,AGEINF,AGESUP,1,nlstate+ndeath, 1,ncovcombmax); free_matrix(prlim,1,nlstate,1,nlstate); /*here or after loop ? */ free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath); } /* mle==-3 arrives here for freeing */ @@ -11890,15 +12442,16 @@ Please run with mle=-1 to get a correct free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath); free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath); free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath); - free_ma3x(cotqvar,1,maxwav,1,nqtv,1,n); - free_ma3x(cotvar,1,maxwav,1,ntv+nqtv,1,n); - free_matrix(coqvar,1,maxwav,1,n); + if(ntv+nqtv>=1)free_ma3x(cotvar,1,maxwav,1,ntv+nqtv,1,n); + if(nqtv>=1)free_ma3x(cotqvar,1,maxwav,1,nqtv,1,n); + if(nqv>=1)free_matrix(coqvar,1,nqv,1,n); free_matrix(covar,0,NCOVMAX,1,n); free_matrix(matcov,1,npar,1,npar); free_matrix(hess,1,npar,1,npar); /*free_vector(delti,1,npar);*/ free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); free_matrix(agev,1,maxwav,1,imx); + free_ma3x(paramstart,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); free_ivector(ncodemax,1,NCOVMAX);