Diff for /imach/src/imach.c between versions 1.2 and 1.109

version 1.2, 2001/03/13 18:10:26 version 1.109, 2006/01/24 19:37:15
Line 1 Line 1
      /* $Id$
 /*********************** Imach **************************************            $State$
   This program computes Healthy Life Expectancies from cross-longitudinal    $Log$
   data. Cross-longitudinal consist in a first survey ("cross") where    Revision 1.109  2006/01/24 19:37:15  brouard
   individuals from different ages are interviewed on their health status    (Module): Comments (lines starting with a #) are allowed in data.
   or degree of  disability. At least a second wave of interviews  
   ("longitudinal") should  measure each new individual health status.    Revision 1.108  2006/01/19 18:05:42  lievre
   Health expectancies are computed from the transistions observed between    Gnuplot problem appeared...
   waves and are computed for each degree of severity of disability (number    To be fixed
   of life states). More degrees you consider, more time is necessary to  
   reach the Maximum Likelihood of the parameters involved in the model.    Revision 1.107  2006/01/19 16:20:37  brouard
   The simplest model is the multinomial logistic model where pij is    Test existence of gnuplot in imach path
   the probabibility to be observed in state j at the second wave conditional  
   to be observed in state i at the first wave. Therefore the model is:    Revision 1.106  2006/01/19 13:24:36  brouard
   log(pij/pii)= aij + bij*age+ cij*sex + etc , where 'age' is age and 'sex'    Some cleaning and links added in html output
   is a covariate. If you want to have a more complex model than "constant and  
   age", you should modify the program where the markup    Revision 1.105  2006/01/05 20:23:19  lievre
     *Covariates have to be included here again* invites you to do it.    *** empty log message ***
   More covariates you add, less is the speed of the convergence.  
     Revision 1.104  2005/09/30 16:11:43  lievre
   The advantage that this computer programme claims, comes from that if the    (Module): sump fixed, loop imx fixed, and simplifications.
   delay between waves is not identical for each individual, or if some    (Module): If the status is missing at the last wave but we know
   individual missed an interview, the information is not rounded or lost, but    that the person is alive, then we can code his/her status as -2
   taken into account using an interpolation or extrapolation.    (instead of missing=-1 in earlier versions) and his/her
   hPijx is the probability to be    contributions to the likelihood is 1 - Prob of dying from last
   observed in state i at age x+h conditional to the observed state i at age    health status (= 1-p13= p11+p12 in the easiest case of somebody in
   x. The delay 'h' can be split into an exact number (nh*stepm) of    the healthy state at last known wave). Version is 0.98
   unobserved intermediate  states. This elementary transition (by month or  
   quarter trimester, semester or year) is model as a multinomial logistic.    Revision 1.103  2005/09/30 15:54:49  lievre
   The hPx matrix is simply the matrix product of nh*stepm elementary matrices    (Module): sump fixed, loop imx fixed, and simplifications.
   and the contribution of each individual to the likelihood is simply hPijx.  
     Revision 1.102  2004/09/15 17:31:30  brouard
   Also this programme outputs the covariance matrix of the parameters but also    Add the possibility to read data file including tab characters.
   of the life expectancies. It also computes the prevalence limits.  
      Revision 1.101  2004/09/15 10:38:38  brouard
   Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).    Fix on curr_time
            Institut national d'études démographiques, Paris.  
   This software have been partly granted by Euro-REVES, a concerted action    Revision 1.100  2004/07/12 18:29:06  brouard
   from the European Union.    Add version for Mac OS X. Just define UNIX in Makefile
   It is copyrighted identically to a GNU software product, ie programme and  
   software can be distributed freely for non commercial use. Latest version    Revision 1.99  2004/06/05 08:57:40  brouard
   can be accessed at http://euroreves.ined.fr/imach .    *** empty log message ***
   **********************************************************************/  
      Revision 1.98  2004/05/16 15:05:56  brouard
 #include <math.h>    New version 0.97 . First attempt to estimate force of mortality
 #include <stdio.h>    directly from the data i.e. without the need of knowing the health
 #include <stdlib.h>    state at each age, but using a Gompertz model: log u =a + b*age .
 #include <unistd.h>    This is the basic analysis of mortality and should be done before any
     other analysis, in order to test if the mortality estimated from the
 #define MAXLINE 256    cross-longitudinal survey is different from the mortality estimated
 #define FILENAMELENGTH 80    from other sources like vital statistic data.
 /*#define DEBUG*/  
 #define windows    The same imach parameter file can be used but the option for mle should be -3.
   
 #define MAXPARM 30 /* Maximum number of parameters for the optimization */    Agnès, who wrote this part of the code, tried to keep most of the
 #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */    former routines in order to include the new code within the former code.
   
 #define NINTERVMAX 8    The output is very simple: only an estimate of the intercept and of
 #define NLSTATEMAX 8 /* Maximum number of live states (for func) */    the slope with 95% confident intervals.
 #define NDEATHMAX 8 /* Maximum number of dead states (for func) */  
 #define NCOVMAX 8 /* Maximum number of covariates */    Current limitations:
 #define MAXN 80000    A) Even if you enter covariates, i.e. with the
 #define YEARM 12. /* Number of months per year */    model= V1+V2 equation for example, the programm does only estimate a unique global model without covariates.
 #define AGESUP 130    B) There is no computation of Life Expectancy nor Life Table.
 #define AGEBASE 40  
     Revision 1.97  2004/02/20 13:25:42  lievre
     Version 0.96d. Population forecasting command line is (temporarily)
 int nvar;    suppressed.
 static int cptcov;  
 int cptcovn;    Revision 1.96  2003/07/15 15:38:55  brouard
 int npar=NPARMAX;    * imach.c (Repository): Errors in subdirf, 2, 3 while printing tmpout is
 int nlstate=2; /* Number of live states */    rewritten within the same printf. Workaround: many printfs.
 int ndeath=1; /* Number of dead states */  
 int ncovmodel, ncov;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */    Revision 1.95  2003/07/08 07:54:34  brouard
     * imach.c (Repository):
 int *wav; /* Number of waves for this individuual 0 is possible */    (Repository): Using imachwizard code to output a more meaningful covariance
 int maxwav; /* Maxim number of waves */    matrix (cov(a12,c31) instead of numbers.
 int mle, weightopt;  
 int **mw; /* mw[mi][i] is number of the mi wave for this individual */    Revision 1.94  2003/06/27 13:00:02  brouard
 int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */    Just cleaning
 double **oldm, **newm, **savm; /* Working pointers to matrices */  
 double **oldms, **newms, **savms; /* Fixed working pointers to matrices */    Revision 1.93  2003/06/25 16:33:55  brouard
 FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest;    (Module): On windows (cygwin) function asctime_r doesn't
 FILE *ficgp, *fichtm;    exist so I changed back to asctime which exists.
 FILE *ficreseij;    (Module): Version 0.96b
   char filerese[FILENAMELENGTH];  
  FILE  *ficresvij;    Revision 1.92  2003/06/25 16:30:45  brouard
   char fileresv[FILENAMELENGTH];    (Module): On windows (cygwin) function asctime_r doesn't
  FILE  *ficresvpl;    exist so I changed back to asctime which exists.
   char fileresvpl[FILENAMELENGTH];  
     Revision 1.91  2003/06/25 15:30:29  brouard
     * imach.c (Repository): Duplicated warning errors corrected.
     (Repository): Elapsed time after each iteration is now output. It
     helps to forecast when convergence will be reached. Elapsed time
 #define NR_END 1    is stamped in powell.  We created a new html file for the graphs
 #define FREE_ARG char*    concerning matrix of covariance. It has extension -cov.htm.
 #define FTOL 1.0e-10  
     Revision 1.90  2003/06/24 12:34:15  brouard
 #define NRANSI    (Module): Some bugs corrected for windows. Also, when
 #define ITMAX 200    mle=-1 a template is output in file "or"mypar.txt with the design
     of the covariance matrix to be input.
 #define TOL 2.0e-4  
     Revision 1.89  2003/06/24 12:30:52  brouard
 #define CGOLD 0.3819660    (Module): Some bugs corrected for windows. Also, when
 #define ZEPS 1.0e-10    mle=-1 a template is output in file "or"mypar.txt with the design
 #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d);    of the covariance matrix to be input.
   
 #define GOLD 1.618034    Revision 1.88  2003/06/23 17:54:56  brouard
 #define GLIMIT 100.0    * imach.c (Repository): Create a sub-directory where all the secondary files are. Only imach, htm, gp and r(imach) are on the main directory. Correct time and other things.
 #define TINY 1.0e-20  
     Revision 1.87  2003/06/18 12:26:01  brouard
 static double maxarg1,maxarg2;    Version 0.96
 #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))  
 #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))    Revision 1.86  2003/06/17 20:04:08  brouard
      (Module): Change position of html and gnuplot routines and added
 #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))    routine fileappend.
 #define rint(a) floor(a+0.5)  
     Revision 1.85  2003/06/17 13:12:43  brouard
 static double sqrarg;    * imach.c (Repository): Check when date of death was earlier that
 #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)    current date of interview. It may happen when the death was just
 #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;}    prior to the death. In this case, dh was negative and likelihood
     was wrong (infinity). We still send an "Error" but patch by
 int imx;    assuming that the date of death was just one stepm after the
 int stepm;    interview.
 /* Stepm, step in month: minimum step interpolation*/    (Repository): Because some people have very long ID (first column)
     we changed int to long in num[] and we added a new lvector for
 int m,nb;    memory allocation. But we also truncated to 8 characters (left
 int *num, firstpass=0, lastpass=4,*cod, *ncodemax;    truncation)
 double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;    (Repository): No more line truncation errors.
 double **pmmij;  
     Revision 1.84  2003/06/13 21:44:43  brouard
 double *weight;    * imach.c (Repository): Replace "freqsummary" at a correct
 int **s; /* Status */    place. It differs from routine "prevalence" which may be called
 double *agedc, **covar, idx;    many times. Probs is memory consuming and must be used with
 int **nbcode, *Tcode, *Tvar, **codtab;    parcimony.
     Version 0.95a3 (should output exactly the same maximization than 0.8a2)
 double ftol=FTOL; /* Tolerance for computing Max Likelihood */  
 double ftolhess; /* Tolerance for computing hessian */    Revision 1.83  2003/06/10 13:39:11  lievre
     *** empty log message ***
   
 /******************************************/    Revision 1.82  2003/06/05 15:57:20  brouard
     Add log in  imach.c and  fullversion number is now printed.
 void replace(char *s, char*t)  
 {  */
   int i;  /*
   int lg=20;     Interpolated Markov Chain
   i=0;  
   lg=strlen(t);    Short summary of the programme:
   for(i=0; i<= lg; i++) {    
     (s[i] = t[i]);    This program computes Healthy Life Expectancies from
     if (t[i]== '\\') s[i]='/';    cross-longitudinal data. Cross-longitudinal data consist in: -1- a
   }    first survey ("cross") where individuals from different ages are
 }    interviewed on their health status or degree of disability (in the
     case of a health survey which is our main interest) -2- at least a
 int nbocc(char *s, char occ)    second wave of interviews ("longitudinal") which measure each change
 {    (if any) in individual health status.  Health expectancies are
   int i,j=0;    computed from the time spent in each health state according to a
   int lg=20;    model. More health states you consider, more time is necessary to reach the
   i=0;    Maximum Likelihood of the parameters involved in the model.  The
   lg=strlen(s);    simplest model is the multinomial logistic model where pij is the
   for(i=0; i<= lg; i++) {    probability to be observed in state j at the second wave
   if  (s[i] == occ ) j++;    conditional to be observed in state i at the first wave. Therefore
   }    the model is: log(pij/pii)= aij + bij*age+ cij*sex + etc , where
   return j;    'age' is age and 'sex' is a covariate. If you want to have a more
 }    complex model than "constant and age", you should modify the program
     where the markup *Covariates have to be included here again* invites
 void cutv(char *u,char *v, char*t, char occ)    you to do it.  More covariates you add, slower the
 {    convergence.
   int i,lg,j,p;  
   i=0;    The advantage of this computer programme, compared to a simple
   if (t[0]== occ) p=0;    multinomial logistic model, is clear when the delay between waves is not
   for(j=0; j<=strlen(t)-1; j++) {    identical for each individual. Also, if a individual missed an
     if((t[j]!= occ) && (t[j+1]==occ)) p=j+1;    intermediate interview, the information is lost, but taken into
   }    account using an interpolation or extrapolation.  
   
   lg=strlen(t);    hPijx is the probability to be observed in state i at age x+h
   for(j=0; j<p; j++) {    conditional to the observed state i at age x. The delay 'h' can be
     (u[j] = t[j]);    split into an exact number (nh*stepm) of unobserved intermediate
     u[p]='\0';    states. This elementary transition (by month, quarter,
   }    semester or year) is modelled as a multinomial logistic.  The hPx
     matrix is simply the matrix product of nh*stepm elementary matrices
    for(j=0; j<= lg; j++) {    and the contribution of each individual to the likelihood is simply
     if (j>=(p+1))(v[j-p-1] = t[j]);    hPijx.
   }  
 }    Also this programme outputs the covariance matrix of the parameters but also
     of the life expectancies. It also computes the stable prevalence. 
     
 /********************** nrerror ********************/    Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).
              Institut national d'études démographiques, Paris.
 void nrerror(char error_text[])    This software have been partly granted by Euro-REVES, a concerted action
 {    from the European Union.
   fprintf(stderr,"ERREUR ...\n");    It is copyrighted identically to a GNU software product, ie programme and
   fprintf(stderr,"%s\n",error_text);    software can be distributed freely for non commercial use. Latest version
   exit(1);    can be accessed at http://euroreves.ined.fr/imach .
 }  
 /*********************** vector *******************/    Help to debug: LD_PRELOAD=/usr/local/lib/libnjamd.so ./imach foo.imach
 double *vector(int nl, int nh)    or better on gdb : set env LD_PRELOAD=/usr/local/lib/libnjamd.so
 {    
   double *v;    **********************************************************************/
   v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));  /*
   if (!v) nrerror("allocation failure in vector");    main
   return v-nl+NR_END;    read parameterfile
 }    read datafile
     concatwav
 /************************ free vector ******************/    freqsummary
 void free_vector(double*v, int nl, int nh)    if (mle >= 1)
 {      mlikeli
   free((FREE_ARG)(v+nl-NR_END));    print results files
 }    if mle==1 
        computes hessian
 /************************ivector *******************************/    read end of parameter file: agemin, agemax, bage, fage, estepm
 int *ivector(long nl,long nh)        begin-prev-date,...
 {    open gnuplot file
   int *v;    open html file
   v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));    stable prevalence
   if (!v) nrerror("allocation failure in ivector");     for age prevalim()
   return v-nl+NR_END;    h Pij x
 }    variance of p varprob
     forecasting if prevfcast==1 prevforecast call prevalence()
 /******************free ivector **************************/    health expectancies
 void free_ivector(int *v, long nl, long nh)    Variance-covariance of DFLE
 {    prevalence()
   free((FREE_ARG)(v+nl-NR_END));     movingaverage()
 }    varevsij() 
     if popbased==1 varevsij(,popbased)
 /******************* imatrix *******************************/    total life expectancies
 int **imatrix(long nrl, long nrh, long ncl, long nch)    Variance of stable prevalence
      /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */   end
 {  */
   long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;  
   int **m;  
    
   /* allocate pointers to rows */   
   m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*)));  #include <math.h>
   if (!m) nrerror("allocation failure 1 in matrix()");  #include <stdio.h>
   m += NR_END;  #include <stdlib.h>
   m -= nrl;  #include <string.h>
    #include <unistd.h>
    
   /* allocate rows and set pointers to them */  #include <limits.h>
   m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int)));  #include <sys/types.h>
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  #include <sys/stat.h>
   m[nrl] += NR_END;  #include <errno.h>
   m[nrl] -= ncl;  extern int errno;
    
   for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;  /* #include <sys/time.h> */
    #include <time.h>
   /* return pointer to array of pointers to rows */  #include "timeval.h"
   return m;  
 }  /* #include <libintl.h> */
   /* #define _(String) gettext (String) */
 /****************** free_imatrix *************************/  
 void free_imatrix(m,nrl,nrh,ncl,nch)  #define MAXLINE 256
       int **m;  
       long nch,ncl,nrh,nrl;  #define GNUPLOTPROGRAM "gnuplot"
      /* free an int matrix allocated by imatrix() */  /*#define GNUPLOTPROGRAM "..\\gp37mgw\\wgnuplot"*/
 {  #define FILENAMELENGTH 132
   free((FREE_ARG) (m[nrl]+ncl-NR_END));  
   free((FREE_ARG) (m+nrl-NR_END));  #define GLOCK_ERROR_NOPATH              -1      /* empty path */
 }  #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */
   
 /******************* matrix *******************************/  #define MAXPARM 30 /* Maximum number of parameters for the optimization */
 double **matrix(long nrl, long nrh, long ncl, long nch)  #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */
 {  
   long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;  #define NINTERVMAX 8
   double **m;  #define NLSTATEMAX 8 /* Maximum number of live states (for func) */
   #define NDEATHMAX 8 /* Maximum number of dead states (for func) */
   m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  #define NCOVMAX 8 /* Maximum number of covariates */
   if (!m) nrerror("allocation failure 1 in matrix()");  #define MAXN 20000
   m += NR_END;  #define YEARM 12. /* Number of months per year */
   m -= nrl;  #define AGESUP 130
   #define AGEBASE 40
   m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  #define AGEGOMP 10. /* Minimal age for Gompertz adjustment */
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  #ifdef UNIX
   m[nrl] += NR_END;  #define DIRSEPARATOR '/'
   m[nrl] -= ncl;  #define CHARSEPARATOR "/"
   #define ODIRSEPARATOR '\\'
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  #else
   return m;  #define DIRSEPARATOR '\\'
 }  #define CHARSEPARATOR "\\"
   #define ODIRSEPARATOR '/'
 /*************************free matrix ************************/  #endif
 void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)  
 {  /* $Id$ */
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  /* $State$ */
   free((FREE_ARG)(m+nrl-NR_END));  
 }  char version[]="Imach version 0.98a, January 2006, INED-EUROREVES ";
   char fullversion[]="$Revision$ $Date$"; 
 /******************* ma3x *******************************/  int erreur, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings  */
 double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)  int nvar;
 {  int cptcovn=0, cptcovage=0, cptcoveff=0,cptcov;
   long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;  int npar=NPARMAX;
   double ***m;  int nlstate=2; /* Number of live states */
   int ndeath=1; /* Number of dead states */
   m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  int ncovmodel, ncovcol;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */
   if (!m) nrerror("allocation failure 1 in matrix()");  int popbased=0;
   m += NR_END;  
   m -= nrl;  int *wav; /* Number of waves for this individuual 0 is possible */
   int maxwav; /* Maxim number of waves */
   m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  int jmin, jmax; /* min, max spacing between 2 waves */
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  int gipmx, gsw; /* Global variables on the number of contributions 
   m[nrl] += NR_END;                     to the likelihood and the sum of weights (done by funcone)*/
   m[nrl] -= ncl;  int mle, weightopt;
   int **mw; /* mw[mi][i] is number of the mi wave for this individual */
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */
   int **bh; /* bh[mi][i] is the bias (+ or -) for this individual if the delay between
   m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));             * wave mi and wave mi+1 is not an exact multiple of stepm. */
   if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");  double jmean; /* Mean space between 2 waves */
   m[nrl][ncl] += NR_END;  double **oldm, **newm, **savm; /* Working pointers to matrices */
   m[nrl][ncl] -= nll;  double **oldms, **newms, **savms; /* Fixed working pointers to matrices */
   for (j=ncl+1; j<=nch; j++)  FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest,*ficresf,*ficrespop;
     m[nrl][j]=m[nrl][j-1]+nlay;  FILE *ficlog, *ficrespow;
    int globpr; /* Global variable for printing or not */
   for (i=nrl+1; i<=nrh; i++) {  double fretone; /* Only one call to likelihood */
     m[i][ncl]=m[i-1l][ncl]+ncol*nlay;  long ipmx; /* Number of contributions */
     for (j=ncl+1; j<=nch; j++)  double sw; /* Sum of weights */
       m[i][j]=m[i][j-1]+nlay;  char filerespow[FILENAMELENGTH];
   }  char fileresilk[FILENAMELENGTH]; /* File of individual contributions to the likelihood */
   return m;  FILE *ficresilk;
 }  FILE *ficgp,*ficresprob,*ficpop, *ficresprobcov, *ficresprobcor;
   FILE *ficresprobmorprev;
 /*************************free ma3x ************************/  FILE *fichtm, *fichtmcov; /* Html File */
 void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)  FILE *ficreseij;
 {  char filerese[FILENAMELENGTH];
   free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));  FILE  *ficresvij;
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  char fileresv[FILENAMELENGTH];
   free((FREE_ARG)(m+nrl-NR_END));  FILE  *ficresvpl;
 }  char fileresvpl[FILENAMELENGTH];
   char title[MAXLINE];
 /***************** f1dim *************************/  char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];
 extern int ncom;  char optionfilext[10], optionfilefiname[FILENAMELENGTH], plotcmd[FILENAMELENGTH];
 extern double *pcom,*xicom;  char tmpout[FILENAMELENGTH],  tmpout2[FILENAMELENGTH]; 
 extern double (*nrfunc)(double []);  char command[FILENAMELENGTH];
    int  outcmd=0;
 double f1dim(double x)  
 {  char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], rfileres[FILENAMELENGTH];
   int j;  
   double f;  char filelog[FILENAMELENGTH]; /* Log file */
   double *xt;  char filerest[FILENAMELENGTH];
    char fileregp[FILENAMELENGTH];
   xt=vector(1,ncom);  char popfile[FILENAMELENGTH];
   for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j];  
   f=(*nrfunc)(xt);  char optionfilegnuplot[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH], optionfilehtmcov[FILENAMELENGTH] ;
   free_vector(xt,1,ncom);  
   return f;  struct timeval start_time, end_time, curr_time, last_time, forecast_time;
 }  struct timezone tzp;
   extern int gettimeofday();
 /*****************brent *************************/  struct tm tmg, tm, tmf, *gmtime(), *localtime();
 double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin)  long time_value;
 {  extern long time();
   int iter;  char strcurr[80], strfor[80];
   double a,b,d,etemp;  
   double fu,fv,fw,fx;  char *endptr;
   double ftemp;  long lval;
   double p,q,r,tol1,tol2,u,v,w,x,xm;  
   double e=0.0;  #define NR_END 1
    #define FREE_ARG char*
   a=(ax < cx ? ax : cx);  #define FTOL 1.0e-10
   b=(ax > cx ? ax : cx);  
   x=w=v=bx;  #define NRANSI 
   fw=fv=fx=(*f)(x);  #define ITMAX 200 
   for (iter=1;iter<=ITMAX;iter++) {  
     xm=0.5*(a+b);  #define TOL 2.0e-4 
     tol2=2.0*(tol1=tol*fabs(x)+ZEPS);  
     /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/  #define CGOLD 0.3819660 
     printf(".");fflush(stdout);  #define ZEPS 1.0e-10 
 #ifdef DEBUG  #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d); 
     printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);  
     /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */  #define GOLD 1.618034 
 #endif  #define GLIMIT 100.0 
     if (fabs(x-xm) <= (tol2-0.5*(b-a))){  #define TINY 1.0e-20 
       *xmin=x;  
       return fx;  static double maxarg1,maxarg2;
     }  #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))
     ftemp=fu;  #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))
     if (fabs(e) > tol1) {    
       r=(x-w)*(fx-fv);  #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))
       q=(x-v)*(fx-fw);  #define rint(a) floor(a+0.5)
       p=(x-v)*q-(x-w)*r;  
       q=2.0*(q-r);  static double sqrarg;
       if (q > 0.0) p = -p;  #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)
       q=fabs(q);  #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;} 
       etemp=e;  int agegomp= AGEGOMP;
       e=d;  
       if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x))  int imx; 
         d=CGOLD*(e=(x >= xm ? a-x : b-x));  int stepm=1;
       else {  /* Stepm, step in month: minimum step interpolation*/
         d=p/q;  
         u=x+d;  int estepm;
         if (u-a < tol2 || b-u < tol2)  /* Estepm, step in month to interpolate survival function in order to approximate Life Expectancy*/
           d=SIGN(tol1,xm-x);  
       }  int m,nb;
     } else {  long *num;
       d=CGOLD*(e=(x >= xm ? a-x : b-x));  int firstpass=0, lastpass=4,*cod, *ncodemax, *Tage,*cens;
     }  double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;
     u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d));  double **pmmij, ***probs;
     fu=(*f)(u);  double *ageexmed,*agecens;
     if (fu <= fx) {  double dateintmean=0;
       if (u >= x) a=x; else b=x;  
       SHFT(v,w,x,u)  double *weight;
         SHFT(fv,fw,fx,fu)  int **s; /* Status */
         } else {  double *agedc, **covar, idx;
           if (u < x) a=u; else b=u;  int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;
           if (fu <= fw || w == x) {  double *lsurv, *lpop, *tpop;
             v=w;  
             w=u;  double ftol=FTOL; /* Tolerance for computing Max Likelihood */
             fv=fw;  double ftolhess; /* Tolerance for computing hessian */
             fw=fu;  
           } else if (fu <= fv || v == x || v == w) {  /**************** split *************************/
             v=u;  static  int split( char *path, char *dirc, char *name, char *ext, char *finame )
             fv=fu;  {
           }    /* From a file name with (full) path (either Unix or Windows) we extract the directory (dirc)
         }       the name of the file (name), its extension only (ext) and its first part of the name (finame)
   }    */ 
   nrerror("Too many iterations in brent");    char  *ss;                            /* pointer */
   *xmin=x;    int   l1, l2;                         /* length counters */
   return fx;  
 }    l1 = strlen(path );                   /* length of path */
     if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );
 /****************** mnbrak ***********************/    ss= strrchr( path, DIRSEPARATOR );            /* find last / */
     if ( ss == NULL ) {                   /* no directory, so determine current directory */
 void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc,      strcpy( name, path );               /* we got the fullname name because no directory */
             double (*func)(double))      /*if(strrchr(path, ODIRSEPARATOR )==NULL)
 {        printf("Warning you should use %s as a separator\n",DIRSEPARATOR);*/
   double ulim,u,r,q, dum;      /* get current working directory */
   double fu;      /*    extern  char* getcwd ( char *buf , int len);*/
        if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {
   *fa=(*func)(*ax);        return( GLOCK_ERROR_GETCWD );
   *fb=(*func)(*bx);      }
   if (*fb > *fa) {      /* got dirc from getcwd*/
     SHFT(dum,*ax,*bx,dum)      printf(" DIRC = %s \n",dirc);
       SHFT(dum,*fb,*fa,dum)    } else {                              /* strip direcotry from path */
       }      ss++;                               /* after this, the filename */
   *cx=(*bx)+GOLD*(*bx-*ax);      l2 = strlen( ss );                  /* length of filename */
   *fc=(*func)(*cx);      if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );
   while (*fb > *fc) {      strcpy( name, ss );         /* save file name */
     r=(*bx-*ax)*(*fb-*fc);      strncpy( dirc, path, l1 - l2 );     /* now the directory */
     q=(*bx-*cx)*(*fb-*fa);      dirc[l1-l2] = 0;                    /* add zero */
     u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/      printf(" DIRC2 = %s \n",dirc);
       (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r));    }
     ulim=(*bx)+GLIMIT*(*cx-*bx);    /* We add a separator at the end of dirc if not exists */
     if ((*bx-u)*(u-*cx) > 0.0) {    l1 = strlen( dirc );                  /* length of directory */
       fu=(*func)(u);    if( dirc[l1-1] != DIRSEPARATOR ){
     } else if ((*cx-u)*(u-ulim) > 0.0) {      dirc[l1] =  DIRSEPARATOR;
       fu=(*func)(u);      dirc[l1+1] = 0; 
       if (fu < *fc) {      printf(" DIRC3 = %s \n",dirc);
         SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx))    }
           SHFT(*fb,*fc,fu,(*func)(u))    ss = strrchr( name, '.' );            /* find last / */
           }    if (ss >0){
     } else if ((u-ulim)*(ulim-*cx) >= 0.0) {      ss++;
       u=ulim;      strcpy(ext,ss);                     /* save extension */
       fu=(*func)(u);      l1= strlen( name);
     } else {      l2= strlen(ss)+1;
       u=(*cx)+GOLD*(*cx-*bx);      strncpy( finame, name, l1-l2);
       fu=(*func)(u);      finame[l1-l2]= 0;
     }    }
     SHFT(*ax,*bx,*cx,u)  
       SHFT(*fa,*fb,*fc,fu)    return( 0 );                          /* we're done */
       }  }
 }  
   
 /*************** linmin ************************/  /******************************************/
   
 int ncom;  void replace_back_to_slash(char *s, char*t)
 double *pcom,*xicom;  {
 double (*nrfunc)(double []);    int i;
      int lg=0;
 void linmin(double p[], double xi[], int n, double *fret,double (*func)(double []))    i=0;
 {    lg=strlen(t);
   double brent(double ax, double bx, double cx,    for(i=0; i<= lg; i++) {
                double (*f)(double), double tol, double *xmin);      (s[i] = t[i]);
   double f1dim(double x);      if (t[i]== '\\') s[i]='/';
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb,    }
               double *fc, double (*func)(double));  }
   int j;  
   double xx,xmin,bx,ax;  int nbocc(char *s, char occ)
   double fx,fb,fa;  {
      int i,j=0;
   ncom=n;    int lg=20;
   pcom=vector(1,n);    i=0;
   xicom=vector(1,n);    lg=strlen(s);
   nrfunc=func;    for(i=0; i<= lg; i++) {
   for (j=1;j<=n;j++) {    if  (s[i] == occ ) j++;
     pcom[j]=p[j];    }
     xicom[j]=xi[j];    return j;
   }  }
   ax=0.0;  
   xx=1.0;  void cutv(char *u,char *v, char*t, char occ)
   mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim);  {
   *fret=brent(ax,xx,bx,f1dim,TOL,&xmin);    /* cuts string t into u and v where u ends before first occurence of char 'occ' 
 #ifdef DEBUG       and v starts after first occurence of char 'occ' : ex cutv(u,v,"abcdef2ghi2j",'2')
   printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);       gives u="abcedf" and v="ghi2j" */
 #endif    int i,lg,j,p=0;
   for (j=1;j<=n;j++) {    i=0;
     xi[j] *= xmin;    for(j=0; j<=strlen(t)-1; j++) {
     p[j] += xi[j];      if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;
   }    }
   free_vector(xicom,1,n);  
   free_vector(pcom,1,n);    lg=strlen(t);
 }    for(j=0; j<p; j++) {
       (u[j] = t[j]);
 /*************** powell ************************/    }
 void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret,       u[p]='\0';
             double (*func)(double []))  
 {     for(j=0; j<= lg; j++) {
   void linmin(double p[], double xi[], int n, double *fret,      if (j>=(p+1))(v[j-p-1] = t[j]);
               double (*func)(double []));    }
   int i,ibig,j;  }
   double del,t,*pt,*ptt,*xit;  
   double fp,fptt;  /********************** nrerror ********************/
   double *xits;  
   pt=vector(1,n);  void nrerror(char error_text[])
   ptt=vector(1,n);  {
   xit=vector(1,n);    fprintf(stderr,"ERREUR ...\n");
   xits=vector(1,n);    fprintf(stderr,"%s\n",error_text);
   *fret=(*func)(p);    exit(EXIT_FAILURE);
   for (j=1;j<=n;j++) pt[j]=p[j];  }
   for (*iter=1;;++(*iter)) {  /*********************** vector *******************/
     fp=(*fret);  double *vector(int nl, int nh)
     ibig=0;  {
     del=0.0;    double *v;
     printf("\nPowell iter=%d -2*LL=%.12f",*iter,*fret);    v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));
     for (i=1;i<=n;i++)    if (!v) nrerror("allocation failure in vector");
       printf(" %d %.12f",i, p[i]);    return v-nl+NR_END;
     printf("\n");  }
     for (i=1;i<=n;i++) {  
       for (j=1;j<=n;j++) xit[j]=xi[j][i];  /************************ free vector ******************/
       fptt=(*fret);  void free_vector(double*v, int nl, int nh)
 #ifdef DEBUG  {
       printf("fret=%lf \n",*fret);    free((FREE_ARG)(v+nl-NR_END));
 #endif  }
       printf("%d",i);fflush(stdout);  
       linmin(p,xit,n,fret,func);  /************************ivector *******************************/
       if (fabs(fptt-(*fret)) > del) {  int *ivector(long nl,long nh)
         del=fabs(fptt-(*fret));  {
         ibig=i;    int *v;
       }    v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));
 #ifdef DEBUG    if (!v) nrerror("allocation failure in ivector");
       printf("%d %.12e",i,(*fret));    return v-nl+NR_END;
       for (j=1;j<=n;j++) {  }
         xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);  
         printf(" x(%d)=%.12e",j,xit[j]);  /******************free ivector **************************/
       }  void free_ivector(int *v, long nl, long nh)
       for(j=1;j<=n;j++)  {
         printf(" p=%.12e",p[j]);    free((FREE_ARG)(v+nl-NR_END));
       printf("\n");  }
 #endif  
     }  /************************lvector *******************************/
     if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {  long *lvector(long nl,long nh)
 #ifdef DEBUG  {
       int k[2],l;    long *v;
       k[0]=1;    v=(long *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(long)));
       k[1]=-1;    if (!v) nrerror("allocation failure in ivector");
       printf("Max: %.12e",(*func)(p));    return v-nl+NR_END;
       for (j=1;j<=n;j++)  }
         printf(" %.12e",p[j]);  
       printf("\n");  /******************free lvector **************************/
       for(l=0;l<=1;l++) {  void free_lvector(long *v, long nl, long nh)
         for (j=1;j<=n;j++) {  {
           ptt[j]=p[j]+(p[j]-pt[j])*k[l];    free((FREE_ARG)(v+nl-NR_END));
           printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);  }
         }  
         printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));  /******************* imatrix *******************************/
       }  int **imatrix(long nrl, long nrh, long ncl, long nch) 
 #endif       /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */ 
   { 
     long i, nrow=nrh-nrl+1,ncol=nch-ncl+1; 
       free_vector(xit,1,n);    int **m; 
       free_vector(xits,1,n);    
       free_vector(ptt,1,n);    /* allocate pointers to rows */ 
       free_vector(pt,1,n);    m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*))); 
       return;    if (!m) nrerror("allocation failure 1 in matrix()"); 
     }    m += NR_END; 
     if (*iter == ITMAX) nrerror("powell exceeding maximum iterations.");    m -= nrl; 
     for (j=1;j<=n;j++) {    
       ptt[j]=2.0*p[j]-pt[j];    
       xit[j]=p[j]-pt[j];    /* allocate rows and set pointers to them */ 
       pt[j]=p[j];    m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int))); 
     }    if (!m[nrl]) nrerror("allocation failure 2 in matrix()"); 
     fptt=(*func)(ptt);    m[nrl] += NR_END; 
     if (fptt < fp) {    m[nrl] -= ncl; 
       t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt);    
       if (t < 0.0) {    for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol; 
         linmin(p,xit,n,fret,func);    
         for (j=1;j<=n;j++) {    /* return pointer to array of pointers to rows */ 
           xi[j][ibig]=xi[j][n];    return m; 
           xi[j][n]=xit[j];  } 
         }  
 #ifdef DEBUG  /****************** free_imatrix *************************/
         printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);  void free_imatrix(m,nrl,nrh,ncl,nch)
         for(j=1;j<=n;j++)        int **m;
           printf(" %.12e",xit[j]);        long nch,ncl,nrh,nrl; 
         printf("\n");       /* free an int matrix allocated by imatrix() */ 
 #endif  { 
       }    free((FREE_ARG) (m[nrl]+ncl-NR_END)); 
     }    free((FREE_ARG) (m+nrl-NR_END)); 
   }  } 
 }  
   /******************* matrix *******************************/
 /**** Prevalence limit ****************/  double **matrix(long nrl, long nrh, long ncl, long nch)
   {
 double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)    long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;
 {    double **m;
   /* Computes the prevalence limit in each live state at age x by left multiplying the unit  
      matrix by transitions matrix until convergence is reached */    m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
     if (!m) nrerror("allocation failure 1 in matrix()");
   int i, ii,j,k;    m += NR_END;
   double min, max, maxmin, maxmax,sumnew=0.;    m -= nrl;
   double **matprod2();  
   double **out, cov[NCOVMAX], **pmij();    m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
   double **newm;    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
   double agefin, delaymax=50 ; /* Max number of years to converge */    m[nrl] += NR_END;
     m[nrl] -= ncl;
   for (ii=1;ii<=nlstate+ndeath;ii++)  
     for (j=1;j<=nlstate+ndeath;j++){    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
       oldm[ii][j]=(ii==j ? 1.0 : 0.0);    return m;
     }    /* print *(*(m+1)+70) or print m[1][70]; print m+1 or print &(m[1]) 
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */     */
   for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){  }
     newm=savm;  
     /* Covariates have to be included here again */  /*************************free matrix ************************/
     cov[1]=1.;  void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)
     cov[2]=agefin;  {
     if (cptcovn>0){    free((FREE_ARG)(m[nrl]+ncl-NR_END));
       for (k=1; k<=cptcovn;k++) {cov[2+k]=nbcode[Tvar[k]][codtab[ij][k]];/*printf("Tcode[ij]=%d nbcode=%d\n",Tcode[ij],nbcode[k][Tcode[ij]]);*/}    free((FREE_ARG)(m+nrl-NR_END));
     }  }
     out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);  
   /******************* ma3x *******************************/
     savm=oldm;  double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)
     oldm=newm;  {
     maxmax=0.;    long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;
     for(j=1;j<=nlstate;j++){    double ***m;
       min=1.;  
       max=0.;    m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
       for(i=1; i<=nlstate; i++) {    if (!m) nrerror("allocation failure 1 in matrix()");
         sumnew=0;    m += NR_END;
         for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];    m -= nrl;
         prlim[i][j]= newm[i][j]/(1-sumnew);  
         max=FMAX(max,prlim[i][j]);    m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
         min=FMIN(min,prlim[i][j]);    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
       }    m[nrl] += NR_END;
       maxmin=max-min;    m[nrl] -= ncl;
       maxmax=FMAX(maxmax,maxmin);  
     }    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
     if(maxmax < ftolpl){  
       return prlim;    m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));
     }    if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");
   }    m[nrl][ncl] += NR_END;
 }    m[nrl][ncl] -= nll;
     for (j=ncl+1; j<=nch; j++) 
 /*************** transition probabilities **********/      m[nrl][j]=m[nrl][j-1]+nlay;
     
 double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )    for (i=nrl+1; i<=nrh; i++) {
 {      m[i][ncl]=m[i-1l][ncl]+ncol*nlay;
   double s1, s2;      for (j=ncl+1; j<=nch; j++) 
   /*double t34;*/        m[i][j]=m[i][j-1]+nlay;
   int i,j,j1, nc, ii, jj;    }
     return m; 
     for(i=1; i<= nlstate; i++){    /*  gdb: p *(m+1) <=> p m[1] and p (m+1) <=> p (m+1) <=> p &(m[1])
     for(j=1; j<i;j++){             &(m[i][j][k]) <=> *((*(m+i) + j)+k)
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){    */
         /*s2 += param[i][j][nc]*cov[nc];*/  }
         s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];  
         /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/  /*************************free ma3x ************************/
       }  void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)
       ps[i][j]=s2;  {
       /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/    free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));
     }    free((FREE_ARG)(m[nrl]+ncl-NR_END));
     for(j=i+1; j<=nlstate+ndeath;j++){    free((FREE_ARG)(m+nrl-NR_END));
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){  }
         s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];  
         /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/  /*************** function subdirf ***********/
       }  char *subdirf(char fileres[])
       ps[i][j]=s2;  {
     }    /* Caution optionfilefiname is hidden */
   }    strcpy(tmpout,optionfilefiname);
   for(i=1; i<= nlstate; i++){    strcat(tmpout,"/"); /* Add to the right */
      s1=0;    strcat(tmpout,fileres);
     for(j=1; j<i; j++)    return tmpout;
       s1+=exp(ps[i][j]);  }
     for(j=i+1; j<=nlstate+ndeath; j++)  
       s1+=exp(ps[i][j]);  /*************** function subdirf2 ***********/
     ps[i][i]=1./(s1+1.);  char *subdirf2(char fileres[], char *preop)
     for(j=1; j<i; j++)  {
       ps[i][j]= exp(ps[i][j])*ps[i][i];    
     for(j=i+1; j<=nlstate+ndeath; j++)    /* Caution optionfilefiname is hidden */
       ps[i][j]= exp(ps[i][j])*ps[i][i];    strcpy(tmpout,optionfilefiname);
     /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */    strcat(tmpout,"/");
   } /* end i */    strcat(tmpout,preop);
     strcat(tmpout,fileres);
   for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){    return tmpout;
     for(jj=1; jj<= nlstate+ndeath; jj++){  }
       ps[ii][jj]=0;  
       ps[ii][ii]=1;  /*************** function subdirf3 ***********/
     }  char *subdirf3(char fileres[], char *preop, char *preop2)
   }  {
     
   /*   for(ii=1; ii<= nlstate+ndeath; ii++){    /* Caution optionfilefiname is hidden */
     for(jj=1; jj<= nlstate+ndeath; jj++){    strcpy(tmpout,optionfilefiname);
      printf("%lf ",ps[ii][jj]);    strcat(tmpout,"/");
    }    strcat(tmpout,preop);
     printf("\n ");    strcat(tmpout,preop2);
     }    strcat(tmpout,fileres);
     printf("\n ");printf("%lf ",cov[2]);*/    return tmpout;
 /*  }
   for(i=1; i<= npar; i++) printf("%f ",x[i]);  
   goto end;*/  /***************** f1dim *************************/
     return ps;  extern int ncom; 
 }  extern double *pcom,*xicom;
   extern double (*nrfunc)(double []); 
 /**************** Product of 2 matrices ******************/   
   double f1dim(double x) 
 double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)  { 
 {    int j; 
   /* Computes the matric product of in(1,nrh-nrl+1)(1,nch-ncl+1) times    double f;
      b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */    double *xt; 
   /* in, b, out are matrice of pointers which should have been initialized   
      before: only the contents of out is modified. The function returns    xt=vector(1,ncom); 
      a pointer to pointers identical to out */    for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j]; 
   long i, j, k;    f=(*nrfunc)(xt); 
   for(i=nrl; i<= nrh; i++)    free_vector(xt,1,ncom); 
     for(k=ncolol; k<=ncoloh; k++)    return f; 
       for(j=ncl,out[i][k]=0.; j<=nch; j++)  } 
         out[i][k] +=in[i][j]*b[j][k];  
   /*****************brent *************************/
   return out;  double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin) 
 }  { 
     int iter; 
     double a,b,d,etemp;
 /************* Higher Matrix Product ***************/    double fu,fv,fw,fx;
     double ftemp;
 double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )    double p,q,r,tol1,tol2,u,v,w,x,xm; 
 {    double e=0.0; 
   /* Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' month   
      duration (i.e. until    a=(ax < cx ? ax : cx); 
      age (in years)  age+nhstepm*stepm/12) by multiplying nhstepm*hstepm matrices.    b=(ax > cx ? ax : cx); 
      Output is stored in matrix po[i][j][h] for h every 'hstepm' step    x=w=v=bx; 
      (typically every 2 years instead of every month which is too big).    fw=fv=fx=(*f)(x); 
      Model is determined by parameters x and covariates have to be    for (iter=1;iter<=ITMAX;iter++) { 
      included manually here.      xm=0.5*(a+b); 
       tol2=2.0*(tol1=tol*fabs(x)+ZEPS); 
      */      /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/
       printf(".");fflush(stdout);
   int i, j, d, h, k;      fprintf(ficlog,".");fflush(ficlog);
   double **out, cov[NCOVMAX];  #ifdef DEBUG
   double **newm;      printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
       fprintf(ficlog,"br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
   /* Hstepm could be zero and should return the unit matrix */      /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */
   for (i=1;i<=nlstate+ndeath;i++)  #endif
     for (j=1;j<=nlstate+ndeath;j++){      if (fabs(x-xm) <= (tol2-0.5*(b-a))){ 
       oldm[i][j]=(i==j ? 1.0 : 0.0);        *xmin=x; 
       po[i][j][0]=(i==j ? 1.0 : 0.0);        return fx; 
     }      } 
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */      ftemp=fu;
   for(h=1; h <=nhstepm; h++){      if (fabs(e) > tol1) { 
     for(d=1; d <=hstepm; d++){        r=(x-w)*(fx-fv); 
       newm=savm;        q=(x-v)*(fx-fw); 
       /* Covariates have to be included here again */        p=(x-v)*q-(x-w)*r; 
       cov[1]=1.;        q=2.0*(q-r); 
       cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;        if (q > 0.0) p = -p; 
       if (cptcovn>0){        q=fabs(q); 
       for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][k]];        etemp=e; 
     }        e=d; 
       /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/        if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x)) 
       /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/          d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
       out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath,        else { 
                    pmij(pmmij,cov,ncovmodel,x,nlstate));          d=p/q; 
       savm=oldm;          u=x+d; 
       oldm=newm;          if (u-a < tol2 || b-u < tol2) 
     }            d=SIGN(tol1,xm-x); 
     for(i=1; i<=nlstate+ndeath; i++)        } 
       for(j=1;j<=nlstate+ndeath;j++) {      } else { 
         po[i][j][h]=newm[i][j];        d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
         /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);      } 
          */      u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d)); 
       }      fu=(*f)(u); 
   } /* end h */      if (fu <= fx) { 
   return po;        if (u >= x) a=x; else b=x; 
 }        SHFT(v,w,x,u) 
           SHFT(fv,fw,fx,fu) 
           } else { 
 /*************** log-likelihood *************/            if (u < x) a=u; else b=u; 
 double func( double *x)            if (fu <= fw || w == x) { 
 {              v=w; 
   int i, ii, j, k, mi, d;              w=u; 
   double l, ll[NLSTATEMAX], cov[NCOVMAX];              fv=fw; 
   double **out;              fw=fu; 
   double sw; /* Sum of weights */            } else if (fu <= fv || v == x || v == w) { 
   double lli; /* Individual log likelihood */              v=u; 
   long ipmx;              fv=fu; 
   /*extern weight */            } 
   /* We are differentiating ll according to initial status */          } 
   /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/    } 
   /*for(i=1;i<imx;i++)    nrerror("Too many iterations in brent"); 
 printf(" %d\n",s[4][i]);    *xmin=x; 
   */    return fx; 
   } 
   for(k=1; k<=nlstate; k++) ll[k]=0.;  
   for (i=1,ipmx=0, sw=0.; i<=imx; i++){  /****************** mnbrak ***********************/
        for(mi=1; mi<= wav[i]-1; mi++){  
       for (ii=1;ii<=nlstate+ndeath;ii++)  void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc, 
         for (j=1;j<=nlstate+ndeath;j++) oldm[ii][j]=(ii==j ? 1.0 : 0.0);              double (*func)(double)) 
             for(d=0; d<dh[mi][i]; d++){  { 
         newm=savm;    double ulim,u,r,q, dum;
           cov[1]=1.;    double fu; 
           cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;   
           if (cptcovn>0){    *fa=(*func)(*ax); 
             for (k=1; k<=cptcovn;k++) {    *fb=(*func)(*bx); 
               cov[2+k]=covar[Tvar[k]][i];    if (*fb > *fa) { 
               /* printf("k=%d cptcovn=%d %lf\n",k,cptcovn,covar[Tvar[k]][i]);*/      SHFT(dum,*ax,*bx,dum) 
             }        SHFT(dum,*fb,*fa,dum) 
             }        } 
           out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,    *cx=(*bx)+GOLD*(*bx-*ax); 
                        1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));    *fc=(*func)(*cx); 
           savm=oldm;    while (*fb > *fc) { 
           oldm=newm;      r=(*bx-*ax)*(*fb-*fc); 
       } /* end mult */      q=(*bx-*cx)*(*fb-*fa); 
          u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/ 
       lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);        (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r)); 
       /* printf(" %f ",out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/      ulim=(*bx)+GLIMIT*(*cx-*bx); 
       ipmx +=1;      if ((*bx-u)*(u-*cx) > 0.0) { 
       sw += weight[i];        fu=(*func)(u); 
       ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;      } else if ((*cx-u)*(u-ulim) > 0.0) { 
     } /* end of wave */        fu=(*func)(u); 
   } /* end of individual */        if (fu < *fc) { 
           SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx)) 
   for(k=1,l=0.; k<=nlstate; k++) l += ll[k];            SHFT(*fb,*fc,fu,(*func)(u)) 
   /* printf("l1=%f l2=%f ",ll[1],ll[2]); */            } 
   l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */      } else if ((u-ulim)*(ulim-*cx) >= 0.0) { 
         u=ulim; 
   return -l;        fu=(*func)(u); 
 }      } else { 
         u=(*cx)+GOLD*(*cx-*bx); 
         fu=(*func)(u); 
 /*********** Maximum Likelihood Estimation ***************/      } 
       SHFT(*ax,*bx,*cx,u) 
 void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))        SHFT(*fa,*fb,*fc,fu) 
 {        } 
   int i,j, iter;  } 
   double **xi,*delti;  
   double fret;  /*************** linmin ************************/
   xi=matrix(1,npar,1,npar);  
   for (i=1;i<=npar;i++)  int ncom; 
     for (j=1;j<=npar;j++)  double *pcom,*xicom;
       xi[i][j]=(i==j ? 1.0 : 0.0);  double (*nrfunc)(double []); 
   printf("Powell\n");   
   powell(p,xi,npar,ftol,&iter,&fret,func);  void linmin(double p[], double xi[], int n, double *fret,double (*func)(double [])) 
   { 
    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));    double brent(double ax, double bx, double cx, 
   fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f ",iter,func(p));                 double (*f)(double), double tol, double *xmin); 
     double f1dim(double x); 
 }    void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, 
                 double *fc, double (*func)(double)); 
 /**** Computes Hessian and covariance matrix ***/    int j; 
 void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))    double xx,xmin,bx,ax; 
 {    double fx,fb,fa;
   double  **a,**y,*x,pd;   
   double **hess;    ncom=n; 
   int i, j,jk;    pcom=vector(1,n); 
   int *indx;    xicom=vector(1,n); 
     nrfunc=func; 
   double hessii(double p[], double delta, int theta, double delti[]);    for (j=1;j<=n;j++) { 
   double hessij(double p[], double delti[], int i, int j);      pcom[j]=p[j]; 
   void lubksb(double **a, int npar, int *indx, double b[]) ;      xicom[j]=xi[j]; 
   void ludcmp(double **a, int npar, int *indx, double *d) ;    } 
     ax=0.0; 
     xx=1.0; 
   hess=matrix(1,npar,1,npar);    mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim); 
     *fret=brent(ax,xx,bx,f1dim,TOL,&xmin); 
   printf("\nCalculation of the hessian matrix. Wait...\n");  #ifdef DEBUG
   for (i=1;i<=npar;i++){    printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
     printf("%d",i);fflush(stdout);    fprintf(ficlog,"retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
     hess[i][i]=hessii(p,ftolhess,i,delti);  #endif
     /*printf(" %f ",p[i]);*/    for (j=1;j<=n;j++) { 
   }      xi[j] *= xmin; 
       p[j] += xi[j]; 
   for (i=1;i<=npar;i++) {    } 
     for (j=1;j<=npar;j++)  {    free_vector(xicom,1,n); 
       if (j>i) {    free_vector(pcom,1,n); 
         printf(".%d%d",i,j);fflush(stdout);  } 
         hess[i][j]=hessij(p,delti,i,j);  
         hess[j][i]=hess[i][j];  char *asc_diff_time(long time_sec, char ascdiff[])
       }  {
     }    long sec_left, days, hours, minutes;
   }    days = (time_sec) / (60*60*24);
   printf("\n");    sec_left = (time_sec) % (60*60*24);
     hours = (sec_left) / (60*60) ;
   printf("\nInverting the hessian to get the covariance matrix. Wait...\n");    sec_left = (sec_left) %(60*60);
      minutes = (sec_left) /60;
   a=matrix(1,npar,1,npar);    sec_left = (sec_left) % (60);
   y=matrix(1,npar,1,npar);    sprintf(ascdiff,"%d day(s) %d hour(s) %d minute(s) %d second(s)",days, hours, minutes, sec_left);  
   x=vector(1,npar);    return ascdiff;
   indx=ivector(1,npar);  }
   for (i=1;i<=npar;i++)  
     for (j=1;j<=npar;j++) a[i][j]=hess[i][j];  /*************** powell ************************/
   ludcmp(a,npar,indx,&pd);  void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret, 
               double (*func)(double [])) 
   for (j=1;j<=npar;j++) {  { 
     for (i=1;i<=npar;i++) x[i]=0;    void linmin(double p[], double xi[], int n, double *fret, 
     x[j]=1;                double (*func)(double [])); 
     lubksb(a,npar,indx,x);    int i,ibig,j; 
     for (i=1;i<=npar;i++){    double del,t,*pt,*ptt,*xit;
       matcov[i][j]=x[i];    double fp,fptt;
     }    double *xits;
   }    int niterf, itmp;
   
   printf("\n#Hessian matrix#\n");    pt=vector(1,n); 
   for (i=1;i<=npar;i++) {    ptt=vector(1,n); 
     for (j=1;j<=npar;j++) {    xit=vector(1,n); 
       printf("%.3e ",hess[i][j]);    xits=vector(1,n); 
     }    *fret=(*func)(p); 
     printf("\n");    for (j=1;j<=n;j++) pt[j]=p[j]; 
   }    for (*iter=1;;++(*iter)) { 
       fp=(*fret); 
   /* Recompute Inverse */      ibig=0; 
   for (i=1;i<=npar;i++)      del=0.0; 
     for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];      last_time=curr_time;
   ludcmp(a,npar,indx,&pd);      (void) gettimeofday(&curr_time,&tzp);
       printf("\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);fflush(stdout);
   /*  printf("\n#Hessian matrix recomputed#\n");      /*    fprintf(ficlog,"\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);
       fprintf(ficrespow,"%d %.12f %ld",*iter,*fret,curr_time.tv_sec-start_time.tv_sec);
   for (j=1;j<=npar;j++) {      */
     for (i=1;i<=npar;i++) x[i]=0;     for (i=1;i<=n;i++) {
     x[j]=1;        printf(" %d %.12f",i, p[i]);
     lubksb(a,npar,indx,x);        fprintf(ficlog," %d %.12lf",i, p[i]);
     for (i=1;i<=npar;i++){        fprintf(ficrespow," %.12lf", p[i]);
       y[i][j]=x[i];      }
       printf("%.3e ",y[i][j]);      printf("\n");
     }      fprintf(ficlog,"\n");
     printf("\n");      fprintf(ficrespow,"\n");fflush(ficrespow);
   }      if(*iter <=3){
   */        tm = *localtime(&curr_time.tv_sec);
         strcpy(strcurr,asctime(&tm));
   free_matrix(a,1,npar,1,npar);  /*       asctime_r(&tm,strcurr); */
   free_matrix(y,1,npar,1,npar);        forecast_time=curr_time; 
   free_vector(x,1,npar);        itmp = strlen(strcurr);
   free_ivector(indx,1,npar);        if(strcurr[itmp-1]=='\n')  /* Windows outputs with a new line */
   free_matrix(hess,1,npar,1,npar);          strcurr[itmp-1]='\0';
         printf("\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
         fprintf(ficlog,"\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
 }        for(niterf=10;niterf<=30;niterf+=10){
           forecast_time.tv_sec=curr_time.tv_sec+(niterf-*iter)*(curr_time.tv_sec-last_time.tv_sec);
 /*************** hessian matrix ****************/          tmf = *localtime(&forecast_time.tv_sec);
 double hessii( double x[], double delta, int theta, double delti[])  /*      asctime_r(&tmf,strfor); */
 {          strcpy(strfor,asctime(&tmf));
   int i;          itmp = strlen(strfor);
   int l=1, lmax=20;          if(strfor[itmp-1]=='\n')
   double k1,k2;          strfor[itmp-1]='\0';
   double p2[NPARMAX+1];          printf("   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   double res;          fprintf(ficlog,"   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;        }
   double fx;      }
   int k=0,kmax=10;      for (i=1;i<=n;i++) { 
   double l1;        for (j=1;j<=n;j++) xit[j]=xi[j][i]; 
         fptt=(*fret); 
   fx=func(x);  #ifdef DEBUG
   for (i=1;i<=npar;i++) p2[i]=x[i];        printf("fret=%lf \n",*fret);
   for(l=0 ; l <=lmax; l++){        fprintf(ficlog,"fret=%lf \n",*fret);
     l1=pow(10,l);  #endif
     delts=delt;        printf("%d",i);fflush(stdout);
     for(k=1 ; k <kmax; k=k+1){        fprintf(ficlog,"%d",i);fflush(ficlog);
       delt = delta*(l1*k);        linmin(p,xit,n,fret,func); 
       p2[theta]=x[theta] +delt;        if (fabs(fptt-(*fret)) > del) { 
       k1=func(p2)-fx;          del=fabs(fptt-(*fret)); 
       p2[theta]=x[theta]-delt;          ibig=i; 
       k2=func(p2)-fx;        } 
       /*res= (k1-2.0*fx+k2)/delt/delt; */  #ifdef DEBUG
       res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */        printf("%d %.12e",i,(*fret));
              fprintf(ficlog,"%d %.12e",i,(*fret));
 #ifdef DEBUG        for (j=1;j<=n;j++) {
       printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);          xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);
 #endif          printf(" x(%d)=%.12e",j,xit[j]);
       /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */          fprintf(ficlog," x(%d)=%.12e",j,xit[j]);
       if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){        }
         k=kmax;        for(j=1;j<=n;j++) {
       }          printf(" p=%.12e",p[j]);
       else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */          fprintf(ficlog," p=%.12e",p[j]);
         k=kmax; l=lmax*10.;        }
       }        printf("\n");
       else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){        fprintf(ficlog,"\n");
         delts=delt;  #endif
       }      } 
     }      if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {
   }  #ifdef DEBUG
   delti[theta]=delts;        int k[2],l;
   return res;          k[0]=1;
 }        k[1]=-1;
         printf("Max: %.12e",(*func)(p));
 double hessij( double x[], double delti[], int thetai,int thetaj)        fprintf(ficlog,"Max: %.12e",(*func)(p));
 {        for (j=1;j<=n;j++) {
   int i;          printf(" %.12e",p[j]);
   int l=1, l1, lmax=20;          fprintf(ficlog," %.12e",p[j]);
   double k1,k2,k3,k4,res,fx;        }
   double p2[NPARMAX+1];        printf("\n");
   int k;        fprintf(ficlog,"\n");
         for(l=0;l<=1;l++) {
   fx=func(x);          for (j=1;j<=n;j++) {
   for (k=1; k<=2; k++) {            ptt[j]=p[j]+(p[j]-pt[j])*k[l];
     for (i=1;i<=npar;i++) p2[i]=x[i];            printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
     p2[thetai]=x[thetai]+delti[thetai]/k;            fprintf(ficlog,"l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;          }
     k1=func(p2)-fx;          printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
            fprintf(ficlog,"func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
     p2[thetai]=x[thetai]+delti[thetai]/k;        }
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;  #endif
     k2=func(p2)-fx;  
    
     p2[thetai]=x[thetai]-delti[thetai]/k;        free_vector(xit,1,n); 
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;        free_vector(xits,1,n); 
     k3=func(p2)-fx;        free_vector(ptt,1,n); 
          free_vector(pt,1,n); 
     p2[thetai]=x[thetai]-delti[thetai]/k;        return; 
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;      } 
     k4=func(p2)-fx;      if (*iter == ITMAX) nrerror("powell exceeding maximum iterations."); 
     res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */      for (j=1;j<=n;j++) { 
 #ifdef DEBUG        ptt[j]=2.0*p[j]-pt[j]; 
     printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);        xit[j]=p[j]-pt[j]; 
 #endif        pt[j]=p[j]; 
   }      } 
   return res;      fptt=(*func)(ptt); 
 }      if (fptt < fp) { 
         t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt); 
 /************** Inverse of matrix **************/        if (t < 0.0) { 
 void ludcmp(double **a, int n, int *indx, double *d)          linmin(p,xit,n,fret,func); 
 {          for (j=1;j<=n;j++) { 
   int i,imax,j,k;            xi[j][ibig]=xi[j][n]; 
   double big,dum,sum,temp;            xi[j][n]=xit[j]; 
   double *vv;          }
    #ifdef DEBUG
   vv=vector(1,n);          printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
   *d=1.0;          fprintf(ficlog,"Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
   for (i=1;i<=n;i++) {          for(j=1;j<=n;j++){
     big=0.0;            printf(" %.12e",xit[j]);
     for (j=1;j<=n;j++)            fprintf(ficlog," %.12e",xit[j]);
       if ((temp=fabs(a[i][j])) > big) big=temp;          }
     if (big == 0.0) nrerror("Singular matrix in routine ludcmp");          printf("\n");
     vv[i]=1.0/big;          fprintf(ficlog,"\n");
   }  #endif
   for (j=1;j<=n;j++) {        }
     for (i=1;i<j;i++) {      } 
       sum=a[i][j];    } 
       for (k=1;k<i;k++) sum -= a[i][k]*a[k][j];  } 
       a[i][j]=sum;  
     }  /**** Prevalence limit (stable prevalence)  ****************/
     big=0.0;  
     for (i=j;i<=n;i++) {  double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)
       sum=a[i][j];  {
       for (k=1;k<j;k++)    /* Computes the prevalence limit in each live state at age x by left multiplying the unit
         sum -= a[i][k]*a[k][j];       matrix by transitions matrix until convergence is reached */
       a[i][j]=sum;  
       if ( (dum=vv[i]*fabs(sum)) >= big) {    int i, ii,j,k;
         big=dum;    double min, max, maxmin, maxmax,sumnew=0.;
         imax=i;    double **matprod2();
       }    double **out, cov[NCOVMAX], **pmij();
     }    double **newm;
     if (j != imax) {    double agefin, delaymax=50 ; /* Max number of years to converge */
       for (k=1;k<=n;k++) {  
         dum=a[imax][k];    for (ii=1;ii<=nlstate+ndeath;ii++)
         a[imax][k]=a[j][k];      for (j=1;j<=nlstate+ndeath;j++){
         a[j][k]=dum;        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       }      }
       *d = -(*d);  
       vv[imax]=vv[j];     cov[1]=1.;
     }   
     indx[j]=imax;   /* Even if hstepm = 1, at least one multiplication by the unit matrix */
     if (a[j][j] == 0.0) a[j][j]=TINY;    for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){
     if (j != n) {      newm=savm;
       dum=1.0/(a[j][j]);      /* Covariates have to be included here again */
       for (i=j+1;i<=n;i++) a[i][j] *= dum;       cov[2]=agefin;
     }    
   }        for (k=1; k<=cptcovn;k++) {
   free_vector(vv,1,n);  /* Doesn't work */          cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
 ;          /*      printf("ij=%d k=%d Tvar[k]=%d nbcode=%d cov=%lf codtab[ij][Tvar[k]]=%d \n",ij,k, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k], codtab[ij][Tvar[k]]);*/
 }        }
         for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
 void lubksb(double **a, int n, int *indx, double b[])        for (k=1; k<=cptcovprod;k++)
 {          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
   int i,ii=0,ip,j;  
   double sum;        /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/
          /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/
   for (i=1;i<=n;i++) {        /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/
     ip=indx[i];      out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);
     sum=b[ip];  
     b[ip]=b[i];      savm=oldm;
     if (ii)      oldm=newm;
       for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j];      maxmax=0.;
     else if (sum) ii=i;      for(j=1;j<=nlstate;j++){
     b[i]=sum;        min=1.;
   }        max=0.;
   for (i=n;i>=1;i--) {        for(i=1; i<=nlstate; i++) {
     sum=b[i];          sumnew=0;
     for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j];          for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];
     b[i]=sum/a[i][i];          prlim[i][j]= newm[i][j]/(1-sumnew);
   }          max=FMAX(max,prlim[i][j]);
 }          min=FMIN(min,prlim[i][j]);
         }
 /************ Frequencies ********************/        maxmin=max-min;
 void  freqsummary(char fileres[], int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax)        maxmax=FMAX(maxmax,maxmin);
 {  /* Some frequencies */      }
        if(maxmax < ftolpl){
   int i, m, jk, k1, i1, j1, bool, z1,z2,j;        return prlim;
   double ***freq; /* Frequencies */      }
   double *pp;    }
   double pos;  }
   FILE *ficresp;  
   char fileresp[FILENAMELENGTH];  /*************** transition probabilities ***************/ 
   
   pp=vector(1,nlstate);  double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )
   {
   strcpy(fileresp,"p");    double s1, s2;
   strcat(fileresp,fileres);    /*double t34;*/
   if((ficresp=fopen(fileresp,"w"))==NULL) {    int i,j,j1, nc, ii, jj;
     printf("Problem with prevalence resultfile: %s\n", fileresp);  
     exit(0);      for(i=1; i<= nlstate; i++){
   }        for(j=1; j<i;j++){
   freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
   j1=0;            /*s2 += param[i][j][nc]*cov[nc];*/
             s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
   j=cptcovn;  /*       printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2); */
   if (cptcovn<1) {j=1;ncodemax[1]=1;}          }
           ps[i][j]=s2;
   for(k1=1; k1<=j;k1++){  /*      printf("s1=%.17e, s2=%.17e\n",s1,s2); */
    for(i1=1; i1<=ncodemax[k1];i1++){        }
        j1++;        for(j=i+1; j<=nlstate+ndeath;j++){
           for (nc=1, s2=0.;nc <=ncovmodel; nc++){
         for (i=-1; i<=nlstate+ndeath; i++)              s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
          for (jk=-1; jk<=nlstate+ndeath; jk++)    /*        printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2); */
            for(m=agemin; m <= agemax+3; m++)          }
              freq[i][jk][m]=0;          ps[i][j]=s2;
                }
        for (i=1; i<=imx; i++) {      }
          bool=1;      /*ps[3][2]=1;*/
          if  (cptcovn>0) {      
            for (z1=1; z1<=cptcovn; z1++)      for(i=1; i<= nlstate; i++){
              if (covar[Tvar[z1]][i]!= nbcode[Tvar[z1]][codtab[j1][z1]]) bool=0;        s1=0;
          }        for(j=1; j<i; j++)
           if (bool==1) {          s1+=exp(ps[i][j]);
            for(m=firstpass; m<=lastpass-1; m++){        for(j=i+1; j<=nlstate+ndeath; j++)
              if(agev[m][i]==0) agev[m][i]=agemax+1;          s1+=exp(ps[i][j]);
              if(agev[m][i]==1) agev[m][i]=agemax+2;        ps[i][i]=1./(s1+1.);
              freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];        for(j=1; j<i; j++)
              freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];          ps[i][j]= exp(ps[i][j])*ps[i][i];
            }        for(j=i+1; j<=nlstate+ndeath; j++)
          }          ps[i][j]= exp(ps[i][j])*ps[i][i];
        }        /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */
         if  (cptcovn>0) {      } /* end i */
          fprintf(ficresp, "\n#Variable");      
          for (z1=1; z1<=cptcovn; z1++) fprintf(ficresp, " V%d=%d",Tvar[z1],nbcode[Tvar[z1]][codtab[j1][z1]]);      for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){
        }        for(jj=1; jj<= nlstate+ndeath; jj++){
        fprintf(ficresp, "\n#");          ps[ii][jj]=0;
        for(i=1; i<=nlstate;i++)          ps[ii][ii]=1;
          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);        }
        fprintf(ficresp, "\n");      }
              
   for(i=(int)agemin; i <= (int)agemax+3; i++){  
     if(i==(int)agemax+3)  /*        for(ii=1; ii<= nlstate+ndeath; ii++){ */
       printf("Total");  /*       for(jj=1; jj<= nlstate+ndeath; jj++){ */
     else  /*         printf("ddd %lf ",ps[ii][jj]); */
       printf("Age %d", i);  /*       } */
     for(jk=1; jk <=nlstate ; jk++){  /*       printf("\n "); */
       for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)  /*        } */
         pp[jk] += freq[jk][m][i];  /*        printf("\n ");printf("%lf ",cov[2]); */
     }         /*
     for(jk=1; jk <=nlstate ; jk++){        for(i=1; i<= npar; i++) printf("%f ",x[i]);
       for(m=-1, pos=0; m <=0 ; m++)        goto end;*/
         pos += freq[jk][m][i];      return ps;
       if(pp[jk]>=1.e-10)  }
         printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);  
       else  /**************** Product of 2 matrices ******************/
         printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);  
     }  double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)
     for(jk=1; jk <=nlstate ; jk++){  {
       for(m=1, pp[jk]=0; m <=nlstate+ndeath; m++)    /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times
         pp[jk] += freq[jk][m][i];       b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */
     }    /* in, b, out are matrice of pointers which should have been initialized 
     for(jk=1,pos=0; jk <=nlstate ; jk++)       before: only the contents of out is modified. The function returns
       pos += pp[jk];       a pointer to pointers identical to out */
     for(jk=1; jk <=nlstate ; jk++){    long i, j, k;
       if(pos>=1.e-5)    for(i=nrl; i<= nrh; i++)
         printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);      for(k=ncolol; k<=ncoloh; k++)
       else        for(j=ncl,out[i][k]=0.; j<=nch; j++)
         printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);          out[i][k] +=in[i][j]*b[j][k];
       if( i <= (int) agemax){  
         if(pos>=1.e-5)    return out;
           fprintf(ficresp," %d %.5f %.0f %.0f",i,pp[jk]/pos, pp[jk],pos);  }
       else  
           fprintf(ficresp," %d NaNq %.0f %.0f",i,pp[jk],pos);  
       }  /************* Higher Matrix Product ***************/
     }  
     for(jk=-1; jk <=nlstate+ndeath; jk++)  double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )
       for(m=-1; m <=nlstate+ndeath; m++)  {
         if(freq[jk][m][i] !=0 ) printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);    /* Computes the transition matrix starting at age 'age' over 
     if(i <= (int) agemax)       'nhstepm*hstepm*stepm' months (i.e. until
       fprintf(ficresp,"\n");       age (in years)  age+nhstepm*hstepm*stepm/12) by multiplying 
     printf("\n");       nhstepm*hstepm matrices. 
     }       Output is stored in matrix po[i][j][h] for h every 'hstepm' step 
     }       (typically every 2 years instead of every month which is too big 
  }       for the memory).
         Model is determined by parameters x and covariates have to be 
   fclose(ficresp);       included manually here. 
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);  
   free_vector(pp,1,nlstate);       */
   
 }  /* End of Freq */    int i, j, d, h, k;
     double **out, cov[NCOVMAX];
 /************* Waves Concatenation ***************/    double **newm;
   
 void  concatwav(int wav[], int **dh, int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)    /* Hstepm could be zero and should return the unit matrix */
 {    for (i=1;i<=nlstate+ndeath;i++)
   /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.      for (j=1;j<=nlstate+ndeath;j++){
      Death is a valid wave (if date is known).        oldm[i][j]=(i==j ? 1.0 : 0.0);
      mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i        po[i][j][0]=(i==j ? 1.0 : 0.0);
      dh[m][i] of dh[mw[mi][i][i] is the delay between two effective waves m=mw[mi][i]      }
      and mw[mi+1][i]. dh depends on stepm.    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
      */    for(h=1; h <=nhstepm; h++){
       for(d=1; d <=hstepm; d++){
   int i, mi, m;        newm=savm;
   int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;        /* Covariates have to be included here again */
 float sum=0.;        cov[1]=1.;
         cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;
   for(i=1; i<=imx; i++){        for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
     mi=0;        for (k=1; k<=cptcovage;k++)
     m=firstpass;          cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
     while(s[m][i] <= nlstate){        for (k=1; k<=cptcovprod;k++)
       if(s[m][i]>=1)          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
         mw[++mi][i]=m;  
       if(m >=lastpass)  
         break;        /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/
       else        /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/
         m++;        out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, 
     }/* end while */                     pmij(pmmij,cov,ncovmodel,x,nlstate));
     if (s[m][i] > nlstate){        savm=oldm;
       mi++;     /* Death is another wave */        oldm=newm;
       /* if(mi==0)  never been interviewed correctly before death */      }
          /* Only death is a correct wave */      for(i=1; i<=nlstate+ndeath; i++)
       mw[mi][i]=m;        for(j=1;j<=nlstate+ndeath;j++) {
     }          po[i][j][h]=newm[i][j];
           /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);
     wav[i]=mi;           */
     if(mi==0)        }
       printf("Warning, no any valid information for:%d line=%d\n",num[i],i);    } /* end h */
   }    return po;
   }
   for(i=1; i<=imx; i++){  
     for(mi=1; mi<wav[i];mi++){  
       if (stepm <=0)  /*************** log-likelihood *************/
         dh[mi][i]=1;  double func( double *x)
       else{  {
         if (s[mw[mi+1][i]][i] > nlstate) {    int i, ii, j, k, mi, d, kk;
           j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12);    double l, ll[NLSTATEMAX], cov[NCOVMAX];
           if(j=0) j=1;  /* Survives at least one month after exam */    double **out;
         }    double sw; /* Sum of weights */
         else{    double lli; /* Individual log likelihood */
           j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));    int s1, s2;
           /*printf("i=%d agevi+1=%lf agevi=%lf j=%d\n", i,agev[mw[mi+1][i]][i],agev[mw[mi][i]][i],j);*/    double bbh, survp;
     long ipmx;
           k=k+1;    /*extern weight */
           if (j >= jmax) jmax=j;    /* We are differentiating ll according to initial status */
           else if (j <= jmin)jmin=j;    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
           sum=sum+j;    /*for(i=1;i<imx;i++) 
         }      printf(" %d\n",s[4][i]);
         jk= j/stepm;    */
         jl= j -jk*stepm;    cov[1]=1.;
         ju= j -(jk+1)*stepm;  
         if(jl <= -ju)    for(k=1; k<=nlstate; k++) ll[k]=0.;
           dh[mi][i]=jk;  
         else    if(mle==1){
           dh[mi][i]=jk+1;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         if(dh[mi][i]==0)        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
           dh[mi][i]=1; /* At least one step */        for(mi=1; mi<= wav[i]-1; mi++){
       }          for (ii=1;ii<=nlstate+ndeath;ii++)
     }            for (j=1;j<=nlstate+ndeath;j++){
   }              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,sum/k);              savm[ii][j]=(ii==j ? 1.0 : 0.0);
 }            }
 /*********** Tricode ****************************/          for(d=0; d<dh[mi][i]; d++){
 void tricode(int *Tvar, int **nbcode, int imx)            newm=savm;
 {            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   int Ndum[80],ij, k, j, i;            for (kk=1; kk<=cptcovage;kk++) {
   int cptcode=0;              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
   for (k=0; k<79; k++) Ndum[k]=0;            }
   for (k=1; k<=7; k++) ncodemax[k]=0;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
                           1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   for (j=1; j<=cptcovn; j++) {            savm=oldm;
     for (i=1; i<=imx; i++) {            oldm=newm;
       ij=(int)(covar[Tvar[j]][i]);          } /* end mult */
       Ndum[ij]++;        
       if (ij > cptcode) cptcode=ij;          /*lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/ /* Original formula */
     }          /* But now since version 0.9 we anticipate for bias at large stepm.
     /*printf("cptcode=%d cptcovn=%d ",cptcode,cptcovn);*/           * If stepm is larger than one month (smallest stepm) and if the exact delay 
     for (i=0; i<=cptcode; i++) {           * (in months) between two waves is not a multiple of stepm, we rounded to 
       if(Ndum[i]!=0) ncodemax[j]++;           * the nearest (and in case of equal distance, to the lowest) interval but now
     }           * we keep into memory the bias bh[mi][i] and also the previous matrix product
             * (i.e to dh[mi][i]-1) saved in 'savm'. Then we inter(extra)polate the
     ij=1;           * probability in order to take into account the bias as a fraction of the way
     for (i=1; i<=ncodemax[j]; i++) {           * from savm to out if bh is negative or even beyond if bh is positive. bh varies
       for (k=0; k<=79; k++) {           * -stepm/2 to stepm/2 .
         if (Ndum[k] != 0) {           * For stepm=1 the results are the same as for previous versions of Imach.
           nbcode[Tvar[j]][ij]=k;           * For stepm > 1 the results are less biased than in previous versions. 
           ij++;           */
         }          s1=s[mw[mi][i]][i];
         if (ij > ncodemax[j]) break;          s2=s[mw[mi+1][i]][i];
       }            bbh=(double)bh[mi][i]/(double)stepm; 
     }          /* bias bh is positive if real duration
   }             * is higher than the multiple of stepm and negative otherwise.
            */
   }          /* lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2]));*/
           if( s2 > nlstate){ 
 /*********** Health Expectancies ****************/            /* i.e. if s2 is a death state and if the date of death is known 
                then the contribution to the likelihood is the probability to 
 void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij)               die between last step unit time and current  step unit time, 
 {               which is also equal to probability to die before dh 
   /* Health expectancies */               minus probability to die before dh-stepm . 
   int i, j, nhstepm, hstepm, h;               In version up to 0.92 likelihood was computed
   double age, agelim,hf;          as if date of death was unknown. Death was treated as any other
   double ***p3mat;          health state: the date of the interview describes the actual state
            and not the date of a change in health state. The former idea was
   fprintf(ficreseij,"# Health expectancies\n");          to consider that at each interview the state was recorded
   fprintf(ficreseij,"# Age");          (healthy, disable or death) and IMaCh was corrected; but when we
   for(i=1; i<=nlstate;i++)          introduced the exact date of death then we should have modified
     for(j=1; j<=nlstate;j++)          the contribution of an exact death to the likelihood. This new
       fprintf(ficreseij," %1d-%1d",i,j);          contribution is smaller and very dependent of the step unit
   fprintf(ficreseij,"\n");          stepm. It is no more the probability to die between last interview
           and month of death but the probability to survive from last
   hstepm=1*YEARM; /*  Every j years of age (in month) */          interview up to one month before death multiplied by the
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */          probability to die within a month. Thanks to Chris
           Jackson for correcting this bug.  Former versions increased
   agelim=AGESUP;          mortality artificially. The bad side is that we add another loop
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */          which slows down the processing. The difference can be up to 10%
     /* nhstepm age range expressed in number of stepm */          lower mortality.
     nhstepm=(int) rint((agelim-age)*YEARM/stepm);            */
     /* Typically if 20 years = 20*12/6=40 stepm */            lli=log(out[s1][s2] - savm[s1][s2]);
     if (stepm >= YEARM) hstepm=1;  
     nhstepm = nhstepm/hstepm;/* Expressed in hstepm, typically 40/4=10 */  
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          } else if  (s2==-2) {
     /* Computed by stepm unit matrices, product of hstepm matrices, stored            for (j=1,survp=0. ; j<=nlstate; j++) 
        in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */              survp += out[s1][j];
     hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);              lli= survp;
           }
           
     for(i=1; i<=nlstate;i++)          else if  (s2==-4) {
       for(j=1; j<=nlstate;j++)            for (j=3,survp=0. ; j<=nlstate; j++) 
         for (h=0, eij[i][j][(int)age]=0; h<=nhstepm; h++){              survp += out[s1][j];
           eij[i][j][(int)age] +=p3mat[i][j][h];            lli= survp;
         }          }
              
     hf=1;          else if  (s2==-5) {
     if (stepm >= YEARM) hf=stepm/YEARM;            for (j=1,survp=0. ; j<=2; j++) 
     fprintf(ficreseij,"%.0f",age );              survp += out[s1][j];
     for(i=1; i<=nlstate;i++)            lli= survp;
       for(j=1; j<=nlstate;j++){          }
         fprintf(ficreseij," %.4f", hf*eij[i][j][(int)age]);  
       }  
     fprintf(ficreseij,"\n");          else{
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);            lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
   }            /*  lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2]));*/ /* linear interpolation */
 }          } 
           /*lli=(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]);*/
 /************ Variance ******************/          /*if(lli ==000.0)*/
 void varevsij(char fileres[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)          /*printf("bbh= %f lli=%f savm=%f out=%f %d\n",bbh,lli,savm[s1][s2], out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]],i); */
 {          ipmx +=1;
   /* Variance of health expectancies */          sw += weight[i];
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   double **newm;        } /* end of wave */
   double **dnewm,**doldm;      } /* end of individual */
   int i, j, nhstepm, hstepm, h;    }  else if(mle==2){
   int k, cptcode;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
    double *xp;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   double **gp, **gm;        for(mi=1; mi<= wav[i]-1; mi++){
   double ***gradg, ***trgradg;          for (ii=1;ii<=nlstate+ndeath;ii++)
   double ***p3mat;            for (j=1;j<=nlstate+ndeath;j++){
   double age,agelim;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   int theta;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
             }
    fprintf(ficresvij,"# Covariances of life expectancies\n");          for(d=0; d<=dh[mi][i]; d++){
   fprintf(ficresvij,"# Age");            newm=savm;
   for(i=1; i<=nlstate;i++)            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     for(j=1; j<=nlstate;j++)            for (kk=1; kk<=cptcovage;kk++) {
       fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
   fprintf(ficresvij,"\n");            }
             out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   xp=vector(1,npar);                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   dnewm=matrix(1,nlstate,1,npar);            savm=oldm;
   doldm=matrix(1,nlstate,1,nlstate);            oldm=newm;
            } /* end mult */
   hstepm=1*YEARM; /* Every year of age */        
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */          s1=s[mw[mi][i]][i];
   agelim = AGESUP;          s2=s[mw[mi+1][i]][i];
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */          bbh=(double)bh[mi][i]/(double)stepm; 
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
     if (stepm >= YEARM) hstepm=1;          ipmx +=1;
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */          sw += weight[i];
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate);        } /* end of wave */
     gp=matrix(0,nhstepm,1,nlstate);      } /* end of individual */
     gm=matrix(0,nhstepm,1,nlstate);    }  else if(mle==3){  /* exponential inter-extrapolation */
       for (i=1,ipmx=0, sw=0.; i<=imx; i++){
     for(theta=1; theta <=npar; theta++){        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
       for(i=1; i<=npar; i++){ /* Computes gradient */        for(mi=1; mi<= wav[i]-1; mi++){
         xp[i] = x[i] + (i==theta ?delti[theta]:0);          for (ii=1;ii<=nlstate+ndeath;ii++)
       }            for (j=1;j<=nlstate+ndeath;j++){
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);                oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);              savm[ii][j]=(ii==j ? 1.0 : 0.0);
       for(j=1; j<= nlstate; j++){            }
         for(h=0; h<=nhstepm; h++){          for(d=0; d<dh[mi][i]; d++){
           for(i=1, gp[h][j]=0.;i<=nlstate;i++)            newm=savm;
             gp[h][j] += prlim[i][i]*p3mat[i][j][h];            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
         }            for (kk=1; kk<=cptcovage;kk++) {
       }              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
                }
       for(i=1; i<=npar; i++) /* Computes gradient */            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
         xp[i] = x[i] - (i==theta ?delti[theta]:0);                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);              savm=oldm;
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);            oldm=newm;
       for(j=1; j<= nlstate; j++){          } /* end mult */
         for(h=0; h<=nhstepm; h++){        
           for(i=1, gm[h][j]=0.;i<=nlstate;i++)          s1=s[mw[mi][i]][i];
             gm[h][j] += prlim[i][i]*p3mat[i][j][h];          s2=s[mw[mi+1][i]][i];
         }          bbh=(double)bh[mi][i]/(double)stepm; 
       }          lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
       for(j=1; j<= nlstate; j++)          ipmx +=1;
         for(h=0; h<=nhstepm; h++){          sw += weight[i];
           gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         }        } /* end of wave */
     } /* End theta */      } /* end of individual */
     }else if (mle==4){  /* ml=4 no inter-extrapolation */
     trgradg =ma3x(0,nhstepm,1,nlstate,1,npar);      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     for(h=0; h<=nhstepm; h++)        for(mi=1; mi<= wav[i]-1; mi++){
       for(j=1; j<=nlstate;j++)          for (ii=1;ii<=nlstate+ndeath;ii++)
         for(theta=1; theta <=npar; theta++)            for (j=1;j<=nlstate+ndeath;j++){
           trgradg[h][j][theta]=gradg[h][theta][j];              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
               savm[ii][j]=(ii==j ? 1.0 : 0.0);
     for(i=1;i<=nlstate;i++)            }
       for(j=1;j<=nlstate;j++)          for(d=0; d<dh[mi][i]; d++){
         vareij[i][j][(int)age] =0.;            newm=savm;
     for(h=0;h<=nhstepm;h++){            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
       for(k=0;k<=nhstepm;k++){            for (kk=1; kk<=cptcovage;kk++) {
         matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
         matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);            }
         for(i=1;i<=nlstate;i++)          
           for(j=1;j<=nlstate;j++)            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
             vareij[i][j][(int)age] += doldm[i][j];                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       }            savm=oldm;
     }            oldm=newm;
     h=1;          } /* end mult */
     if (stepm >= YEARM) h=stepm/YEARM;        
     fprintf(ficresvij,"%.0f ",age );          s1=s[mw[mi][i]][i];
     for(i=1; i<=nlstate;i++)          s2=s[mw[mi+1][i]][i];
       for(j=1; j<=nlstate;j++){          if( s2 > nlstate){ 
         fprintf(ficresvij," %.4f", h*vareij[i][j][(int)age]);            lli=log(out[s1][s2] - savm[s1][s2]);
       }          }else{
     fprintf(ficresvij,"\n");            lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
     free_matrix(gp,0,nhstepm,1,nlstate);          }
     free_matrix(gm,0,nhstepm,1,nlstate);          ipmx +=1;
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);          sw += weight[i];
     free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);  /*      printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
   } /* End age */        } /* end of wave */
        } /* end of individual */
   free_vector(xp,1,npar);    }else{  /* ml=5 no inter-extrapolation no jackson =0.8a */
   free_matrix(doldm,1,nlstate,1,npar);      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
   free_matrix(dnewm,1,nlstate,1,nlstate);        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
         for(mi=1; mi<= wav[i]-1; mi++){
 }          for (ii=1;ii<=nlstate+ndeath;ii++)
             for (j=1;j<=nlstate+ndeath;j++){
 /************ Variance of prevlim ******************/              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
 void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)              savm[ii][j]=(ii==j ? 1.0 : 0.0);
 {            }
   /* Variance of prevalence limit */          for(d=0; d<dh[mi][i]; d++){
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/            newm=savm;
   double **newm;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   double **dnewm,**doldm;            for (kk=1; kk<=cptcovage;kk++) {
   int i, j, nhstepm, hstepm;              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
   int k, cptcode;            }
   double *xp;          
   double *gp, *gm;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   double **gradg, **trgradg;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   double age,agelim;            savm=oldm;
   int theta;            oldm=newm;
              } /* end mult */
   fprintf(ficresvpl,"# Standard deviation of prevalences limit\n");        
   fprintf(ficresvpl,"# Age");          s1=s[mw[mi][i]][i];
   for(i=1; i<=nlstate;i++)          s2=s[mw[mi+1][i]][i];
       fprintf(ficresvpl," %1d-%1d",i,i);          lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
   fprintf(ficresvpl,"\n");          ipmx +=1;
           sw += weight[i];
   xp=vector(1,npar);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   dnewm=matrix(1,nlstate,1,npar);          /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]);*/
   doldm=matrix(1,nlstate,1,nlstate);        } /* end of wave */
        } /* end of individual */
   hstepm=1*YEARM; /* Every year of age */    } /* End of if */
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
   agelim = AGESUP;    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */    return -l;
     if (stepm >= YEARM) hstepm=1;  }
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */  
     gradg=matrix(1,npar,1,nlstate);  /*************** log-likelihood *************/
     gp=vector(1,nlstate);  double funcone( double *x)
     gm=vector(1,nlstate);  {
     /* Same as likeli but slower because of a lot of printf and if */
     for(theta=1; theta <=npar; theta++){    int i, ii, j, k, mi, d, kk;
       for(i=1; i<=npar; i++){ /* Computes gradient */    double l, ll[NLSTATEMAX], cov[NCOVMAX];
         xp[i] = x[i] + (i==theta ?delti[theta]:0);    double **out;
       }    double lli; /* Individual log likelihood */
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    double llt;
       for(i=1;i<=nlstate;i++)    int s1, s2;
         gp[i] = prlim[i][i];    double bbh, survp;
        /*extern weight */
       for(i=1; i<=npar; i++) /* Computes gradient */    /* We are differentiating ll according to initial status */
         xp[i] = x[i] - (i==theta ?delti[theta]:0);    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    /*for(i=1;i<imx;i++) 
       for(i=1;i<=nlstate;i++)      printf(" %d\n",s[4][i]);
         gm[i] = prlim[i][i];    */
     cov[1]=1.;
       for(i=1;i<=nlstate;i++)  
         gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];    for(k=1; k<=nlstate; k++) ll[k]=0.;
     } /* End theta */  
     for (i=1,ipmx=0, sw=0.; i<=imx; i++){
     trgradg =matrix(1,nlstate,1,npar);      for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
       for(mi=1; mi<= wav[i]-1; mi++){
     for(j=1; j<=nlstate;j++)        for (ii=1;ii<=nlstate+ndeath;ii++)
       for(theta=1; theta <=npar; theta++)          for (j=1;j<=nlstate+ndeath;j++){
         trgradg[j][theta]=gradg[theta][j];            oldm[ii][j]=(ii==j ? 1.0 : 0.0);
             savm[ii][j]=(ii==j ? 1.0 : 0.0);
     for(i=1;i<=nlstate;i++)          }
       varpl[i][(int)age] =0.;        for(d=0; d<dh[mi][i]; d++){
     matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);          newm=savm;
     matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);          cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     for(i=1;i<=nlstate;i++)          for (kk=1; kk<=cptcovage;kk++) {
       varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */            cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
           }
     fprintf(ficresvpl,"%.0f ",age );          out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     for(i=1; i<=nlstate;i++)                       1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));          savm=oldm;
     fprintf(ficresvpl,"\n");          oldm=newm;
     free_vector(gp,1,nlstate);        } /* end mult */
     free_vector(gm,1,nlstate);        
     free_matrix(gradg,1,npar,1,nlstate);        s1=s[mw[mi][i]][i];
     free_matrix(trgradg,1,nlstate,1,npar);        s2=s[mw[mi+1][i]][i];
   } /* End age */        bbh=(double)bh[mi][i]/(double)stepm; 
         /* bias is positive if real duration
   free_vector(xp,1,npar);         * is higher than the multiple of stepm and negative otherwise.
   free_matrix(doldm,1,nlstate,1,npar);         */
   free_matrix(dnewm,1,nlstate,1,nlstate);        if( s2 > nlstate && (mle <5) ){  /* Jackson */
           lli=log(out[s1][s2] - savm[s1][s2]);
 }        } else if (mle==1){
           lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
         } else if(mle==2){
           lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
 /***********************************************/        } else if(mle==3){  /* exponential inter-extrapolation */
 /**************** Main Program *****************/          lli= (savm[s1][s2]>(double)1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
 /***********************************************/        } else if (mle==4){  /* mle=4 no inter-extrapolation */
           lli=log(out[s1][s2]); /* Original formula */
 /*int main(int argc, char *argv[])*/        } else{  /* ml>=5 no inter-extrapolation no jackson =0.8a */
 int main()          lli=log(out[s1][s2]); /* Original formula */
 {        } /* End of if */
         ipmx +=1;
   int i,j, k, n=MAXN,iter,m,size,cptcode, aaa, cptcod;        sw += weight[i];
   double agedeb, agefin,hf;        ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   double agemin=1.e20, agemax=-1.e20;  /*       printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
         if(globpr){
   double fret;          fprintf(ficresilk,"%9d %6d %1d %1d %1d %1d %3d %10.6f %6.4f\
   double **xi,tmp,delta;   %10.6f %10.6f %10.6f ", \
                   num[i],i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],
   double dum; /* Dummy variable */                  2*weight[i]*lli,out[s1][s2],savm[s1][s2]);
   double ***p3mat;          for(k=1,llt=0.,l=0.; k<=nlstate; k++){
   int *indx;            llt +=ll[k]*gipmx/gsw;
   char line[MAXLINE], linepar[MAXLINE];            fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw);
   char title[MAXLINE];          }
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];          fprintf(ficresilk," %10.6f\n", -llt);
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH];        }
   char filerest[FILENAMELENGTH];      } /* end of wave */
   char fileregp[FILENAMELENGTH];    } /* end of individual */
   char path[80],pathc[80],pathcd[80],pathtot[80],model[20];    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
   int firstobs=1, lastobs=10;    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
   int sdeb, sfin; /* Status at beginning and end */    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
   int c,  h , cpt,l;    if(globpr==0){ /* First time we count the contributions and weights */
   int ju,jl, mi;      gipmx=ipmx;
   int i1,j1, k1,jk,aa,bb, stepsize;      gsw=sw;
   int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,**adl,*tab;    }
      return -l;
   int hstepm, nhstepm;  }
   double bage, fage, age, agelim, agebase;  
   double ftolpl=FTOL;  
   double **prlim;  /*************** function likelione ***********/
   double *severity;  void likelione(FILE *ficres,double p[], int npar, int nlstate, int *globpri, long *ipmx, double *sw, double *fretone, double (*funcone)(double []))
   double ***param; /* Matrix of parameters */  {
   double  *p;    /* This routine should help understanding what is done with 
   double **matcov; /* Matrix of covariance */       the selection of individuals/waves and
   double ***delti3; /* Scale */       to check the exact contribution to the likelihood.
   double *delti; /* Scale */       Plotting could be done.
   double ***eij, ***vareij;     */
   double **varpl; /* Variances of prevalence limits by age */    int k;
   double *epj, vepp;  
   char version[80]="Imach version 62c, May 1999, INED-EUROREVES ";    if(*globpri !=0){ /* Just counts and sums, no printings */
   char *alph[]={"a","a","b","c","d","e"}, str[4];      strcpy(fileresilk,"ilk"); 
   char z[1]="c", occ;      strcat(fileresilk,fileres);
 #include <sys/time.h>      if((ficresilk=fopen(fileresilk,"w"))==NULL) {
 #include <time.h>        printf("Problem with resultfile: %s\n", fileresilk);
   char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];        fprintf(ficlog,"Problem with resultfile: %s\n", fileresilk);
   /* long total_usecs;      }
   struct timeval start_time, end_time;      fprintf(ficresilk, "#individual(line's_record) s1 s2 wave# effective_wave# number_of_matrices_product pij weight -2ln(pij)*weight 0pij_x 0pij_(x-stepm) cumulating_loglikeli_by_health_state(reweighted=-2ll*weightXnumber_of_contribs/sum_of_weights) and_total\n");
        fprintf(ficresilk, "#num_i i s1 s2 mi mw dh likeli weight 2wlli out sav ");
   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */      /*  i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],2*weight[i]*lli,out[s1][s2],savm[s1][s2]); */
       for(k=1; k<=nlstate; k++) 
         fprintf(ficresilk," -2*gipw/gsw*weight*ll[%d]++",k);
   printf("\nIMACH, Version 0.63");      fprintf(ficresilk," -2*gipw/gsw*weight*ll(total)\n");
   printf("\nEnter the parameter file name: ");    }
   
 #ifdef windows    *fretone=(*funcone)(p);
   scanf("%s",pathtot);    if(*globpri !=0){
   getcwd(pathcd, size);      fclose(ficresilk);
   cutv(path,optionfile,pathtot,'\\');      fprintf(fichtm,"\n<br>File of contributions to the likelihood: <a href=\"%s\">%s</a><br>\n",subdirf(fileresilk),subdirf(fileresilk));
   chdir(path);      fflush(fichtm); 
   replace(pathc,path);    } 
 #endif    return;
 #ifdef unix  }
   scanf("%s",optionfile);  
 #endif  
   /*********** Maximum Likelihood Estimation ***************/
 /*-------- arguments in the command line --------*/  
   void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))
   strcpy(fileres,"r");  {
   strcat(fileres, optionfile);    int i,j, iter;
     double **xi;
   /*---------arguments file --------*/    double fret;
     double fretone; /* Only one call to likelihood */
   if((ficpar=fopen(optionfile,"r"))==NULL)    {    /*  char filerespow[FILENAMELENGTH];*/
     printf("Problem with optionfile %s\n",optionfile);    xi=matrix(1,npar,1,npar);
     goto end;    for (i=1;i<=npar;i++)
   }      for (j=1;j<=npar;j++)
         xi[i][j]=(i==j ? 1.0 : 0.0);
   strcpy(filereso,"o");    printf("Powell\n");  fprintf(ficlog,"Powell\n");
   strcat(filereso,fileres);    strcpy(filerespow,"pow"); 
   if((ficparo=fopen(filereso,"w"))==NULL) {    strcat(filerespow,fileres);
     printf("Problem with Output resultfile: %s\n", filereso);goto end;    if((ficrespow=fopen(filerespow,"w"))==NULL) {
   }      printf("Problem with resultfile: %s\n", filerespow);
       fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
   /* Reads comments: lines beginning with '#' */    }
   while((c=getc(ficpar))=='#' && c!= EOF){    fprintf(ficrespow,"# Powell\n# iter -2*LL");
     ungetc(c,ficpar);    for (i=1;i<=nlstate;i++)
     fgets(line, MAXLINE, ficpar);      for(j=1;j<=nlstate+ndeath;j++)
     puts(line);        if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
     fputs(line,ficparo);    fprintf(ficrespow,"\n");
   }  
   ungetc(c,ficpar);    powell(p,xi,npar,ftol,&iter,&fret,func);
   
   fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncov, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);    fclose(ficrespow);
   printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate,ndeath, maxwav, mle, weightopt,model);    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));
   fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncov,nlstate,ndeath,maxwav, mle, weightopt,model);    fprintf(ficlog,"\n#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
     fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
   covar=matrix(1,NCOVMAX,1,n);      
   if (strlen(model)<=1) cptcovn=0;  }
   else {  
     j=0;  /**** Computes Hessian and covariance matrix ***/
     j=nbocc(model,'+');  void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))
     cptcovn=j+1;  {
   }    double  **a,**y,*x,pd;
     double **hess;
   ncovmodel=2+cptcovn;    int i, j,jk;
   nvar=ncovmodel-1; /* Suppressing age as a basic covariate */    int *indx;
    
   /* Read guess parameters */    double hessii(double p[], double delta, int theta, double delti[],double (*func)(double []),int npar);
   /* Reads comments: lines beginning with '#' */    double hessij(double p[], double delti[], int i, int j,double (*func)(double []),int npar);
   while((c=getc(ficpar))=='#' && c!= EOF){    void lubksb(double **a, int npar, int *indx, double b[]) ;
     ungetc(c,ficpar);    void ludcmp(double **a, int npar, int *indx, double *d) ;
     fgets(line, MAXLINE, ficpar);    double gompertz(double p[]);
     puts(line);    hess=matrix(1,npar,1,npar);
     fputs(line,ficparo);  
   }    printf("\nCalculation of the hessian matrix. Wait...\n");
   ungetc(c,ficpar);    fprintf(ficlog,"\nCalculation of the hessian matrix. Wait...\n");
      for (i=1;i<=npar;i++){
   param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);      printf("%d",i);fflush(stdout);
     for(i=1; i <=nlstate; i++)      fprintf(ficlog,"%d",i);fflush(ficlog);
     for(j=1; j <=nlstate+ndeath-1; j++){     
       fscanf(ficpar,"%1d%1d",&i1,&j1);       hess[i][i]=hessii(p,ftolhess,i,delti,func,npar);
       fprintf(ficparo,"%1d%1d",i1,j1);      
       printf("%1d%1d",i,j);      /*  printf(" %f ",p[i]);
       for(k=1; k<=ncovmodel;k++){          printf(" %lf %lf %lf",hess[i][i],ftolhess,delti[i]);*/
         fscanf(ficpar," %lf",&param[i][j][k]);    }
         printf(" %lf",param[i][j][k]);    
         fprintf(ficparo," %lf",param[i][j][k]);    for (i=1;i<=npar;i++) {
       }      for (j=1;j<=npar;j++)  {
       fscanf(ficpar,"\n");        if (j>i) { 
       printf("\n");          printf(".%d%d",i,j);fflush(stdout);
       fprintf(ficparo,"\n");          fprintf(ficlog,".%d%d",i,j);fflush(ficlog);
     }          hess[i][j]=hessij(p,delti,i,j,func,npar);
            
   npar= (nlstate+ndeath-1)*nlstate*ncovmodel;          hess[j][i]=hess[i][j];    
   p=param[1][1];          /*printf(" %lf ",hess[i][j]);*/
          }
   /* Reads comments: lines beginning with '#' */      }
   while((c=getc(ficpar))=='#' && c!= EOF){    }
     ungetc(c,ficpar);    printf("\n");
     fgets(line, MAXLINE, ficpar);    fprintf(ficlog,"\n");
     puts(line);  
     fputs(line,ficparo);    printf("\nInverting the hessian to get the covariance matrix. Wait...\n");
   }    fprintf(ficlog,"\nInverting the hessian to get the covariance matrix. Wait...\n");
   ungetc(c,ficpar);    
     a=matrix(1,npar,1,npar);
   delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);    y=matrix(1,npar,1,npar);
   delti=vector(1,npar); /* Scale of each paramater (output from hesscov) */    x=vector(1,npar);
   for(i=1; i <=nlstate; i++){    indx=ivector(1,npar);
     for(j=1; j <=nlstate+ndeath-1; j++){    for (i=1;i<=npar;i++)
       fscanf(ficpar,"%1d%1d",&i1,&j1);      for (j=1;j<=npar;j++) a[i][j]=hess[i][j];
       printf("%1d%1d",i,j);    ludcmp(a,npar,indx,&pd);
       fprintf(ficparo,"%1d%1d",i1,j1);  
       for(k=1; k<=ncovmodel;k++){    for (j=1;j<=npar;j++) {
         fscanf(ficpar,"%le",&delti3[i][j][k]);      for (i=1;i<=npar;i++) x[i]=0;
         printf(" %le",delti3[i][j][k]);      x[j]=1;
         fprintf(ficparo," %le",delti3[i][j][k]);      lubksb(a,npar,indx,x);
       }      for (i=1;i<=npar;i++){ 
       fscanf(ficpar,"\n");        matcov[i][j]=x[i];
       printf("\n");      }
       fprintf(ficparo,"\n");    }
     }  
   }    printf("\n#Hessian matrix#\n");
   delti=delti3[1][1];    fprintf(ficlog,"\n#Hessian matrix#\n");
      for (i=1;i<=npar;i++) { 
   /* Reads comments: lines beginning with '#' */      for (j=1;j<=npar;j++) { 
   while((c=getc(ficpar))=='#' && c!= EOF){        printf("%.3e ",hess[i][j]);
     ungetc(c,ficpar);        fprintf(ficlog,"%.3e ",hess[i][j]);
     fgets(line, MAXLINE, ficpar);      }
     puts(line);      printf("\n");
     fputs(line,ficparo);      fprintf(ficlog,"\n");
   }    }
   ungetc(c,ficpar);  
      /* Recompute Inverse */
   matcov=matrix(1,npar,1,npar);    for (i=1;i<=npar;i++)
   for(i=1; i <=npar; i++){      for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];
     fscanf(ficpar,"%s",&str);    ludcmp(a,npar,indx,&pd);
     printf("%s",str);  
     fprintf(ficparo,"%s",str);    /*  printf("\n#Hessian matrix recomputed#\n");
     for(j=1; j <=i; j++){  
       fscanf(ficpar," %le",&matcov[i][j]);    for (j=1;j<=npar;j++) {
       printf(" %.5le",matcov[i][j]);      for (i=1;i<=npar;i++) x[i]=0;
       fprintf(ficparo," %.5le",matcov[i][j]);      x[j]=1;
     }      lubksb(a,npar,indx,x);
     fscanf(ficpar,"\n");      for (i=1;i<=npar;i++){ 
     printf("\n");        y[i][j]=x[i];
     fprintf(ficparo,"\n");        printf("%.3e ",y[i][j]);
   }        fprintf(ficlog,"%.3e ",y[i][j]);
   for(i=1; i <=npar; i++)      }
     for(j=i+1;j<=npar;j++)      printf("\n");
       matcov[i][j]=matcov[j][i];      fprintf(ficlog,"\n");
        }
   printf("\n");    */
   
     free_matrix(a,1,npar,1,npar);
    if(mle==1){    free_matrix(y,1,npar,1,npar);
     /*-------- data file ----------*/    free_vector(x,1,npar);
     if((ficres =fopen(fileres,"w"))==NULL) {    free_ivector(indx,1,npar);
       printf("Problem with resultfile: %s\n", fileres);goto end;    free_matrix(hess,1,npar,1,npar);
     }  
     fprintf(ficres,"#%s\n",version);  
      }
     if((fic=fopen(datafile,"r"))==NULL)    {  
       printf("Problem with datafile: %s\n", datafile);goto end;  /*************** hessian matrix ****************/
     }  double hessii(double x[], double delta, int theta, double delti[], double (*func)(double []), int npar)
   {
     n= lastobs;    int i;
     severity = vector(1,maxwav);    int l=1, lmax=20;
     outcome=imatrix(1,maxwav+1,1,n);    double k1,k2;
     num=ivector(1,n);    double p2[NPARMAX+1];
     moisnais=vector(1,n);    double res;
     annais=vector(1,n);    double delt=0.0001, delts, nkhi=10.,nkhif=1., khi=1.e-4;
     moisdc=vector(1,n);    double fx;
     andc=vector(1,n);    int k=0,kmax=10;
     agedc=vector(1,n);    double l1;
     cod=ivector(1,n);  
     weight=vector(1,n);    fx=func(x);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */    for (i=1;i<=npar;i++) p2[i]=x[i];
     mint=matrix(1,maxwav,1,n);    for(l=0 ; l <=lmax; l++){
     anint=matrix(1,maxwav,1,n);      l1=pow(10,l);
     s=imatrix(1,maxwav+1,1,n);      delts=delt;
     adl=imatrix(1,maxwav+1,1,n);          for(k=1 ; k <kmax; k=k+1){
     tab=ivector(1,NCOVMAX);        delt = delta*(l1*k);
     ncodemax=ivector(1,NCOVMAX);        p2[theta]=x[theta] +delt;
         k1=func(p2)-fx;
     i=1;        p2[theta]=x[theta]-delt;
     while (fgets(line, MAXLINE, fic) != NULL)    {        k2=func(p2)-fx;
       if ((i >= firstobs) && (i <=lastobs)) {        /*res= (k1-2.0*fx+k2)/delt/delt; */
                res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */
         for (j=maxwav;j>=1;j--){        
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb);  #ifdef DEBUG
           strcpy(line,stra);        printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);        fprintf(ficlog,"%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);  #endif
         }        /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */
                if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);          k=kmax;
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);        }
         else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);          k=kmax; l=lmax*10.;
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);        }
         else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){ 
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);          delts=delt;
         for (j=ncov;j>=1;j--){        }
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);      }
         }    }
         num[i]=atol(stra);    delti[theta]=delts;
     return res; 
         /* printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));*/    
   }
         /*printf("%d %.lf %.lf %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),(covar[3][i]), (covar[4][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]));*/  
   double hessij( double x[], double delti[], int thetai,int thetaj,double (*func)(double []),int npar)
         i=i+1;  {
       }    int i;
     }    int l=1, l1, lmax=20;
     /*scanf("%d",i);*/    double k1,k2,k3,k4,res,fx;
     double p2[NPARMAX+1];
   imx=i-1; /* Number of individuals */    int k;
    
   /* Calculation of the number of parameter from char model*/    fx=func(x);
   Tvar=ivector(1,8);        for (k=1; k<=2; k++) {
          for (i=1;i<=npar;i++) p2[i]=x[i];
   if (strlen(model) >1){      p2[thetai]=x[thetai]+delti[thetai]/k;
     j=0;      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
     j=nbocc(model,'+');      k1=func(p2)-fx;
     cptcovn=j+1;    
        p2[thetai]=x[thetai]+delti[thetai]/k;
     strcpy(modelsav,model);      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
     if (j==0) {      k2=func(p2)-fx;
       cutv(stra,strb,modelsav,'V'); Tvar[1]=atoi(strb);    
     }      p2[thetai]=x[thetai]-delti[thetai]/k;
     else {      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
       for(i=j; i>=1;i--){      k3=func(p2)-fx;
         cutv(stra,strb,modelsav,'+');    
         if (strchr(strb,'*')) {      p2[thetai]=x[thetai]-delti[thetai]/k;
           cutv(strd,strc,strb,'*');      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
           cutv(strb,stre,strc,'V');Tvar[i+1]=ncov+1;      k4=func(p2)-fx;
           cutv(strb,strc,strd,'V');      res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */
           for (k=1; k<=lastobs;k++)  #ifdef DEBUG
             covar[ncov+1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];      printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
         }      fprintf(ficlog,"%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
         else {  #endif
           cutv(strd,strc,strb,'V');    }
           Tvar[i+1]=atoi(strc);    return res;
         }  }
         strcpy(modelsav,stra);    
       }  /************** Inverse of matrix **************/
       /*cutv(strd,strc,stra,'V');*/  void ludcmp(double **a, int n, int *indx, double *d) 
       Tvar[1]=atoi(strc);  { 
     }    int i,imax,j,k; 
   }    double big,dum,sum,temp; 
   /*printf("tvar=%d ",Tvar[1]);*/    double *vv; 
   /*scanf("%d ",i);*/   
     fclose(fic);    vv=vector(1,n); 
     *d=1.0; 
     if (weightopt != 1) { /* Maximisation without weights*/    for (i=1;i<=n;i++) { 
       for(i=1;i<=n;i++) weight[i]=1.0;      big=0.0; 
     }      for (j=1;j<=n;j++) 
     /*-calculation of age at interview from date of interview and age at death -*/        if ((temp=fabs(a[i][j])) > big) big=temp; 
     agev=matrix(1,maxwav,1,imx);      if (big == 0.0) nrerror("Singular matrix in routine ludcmp"); 
          vv[i]=1.0/big; 
     for (i=1; i<=imx; i++)  {    } 
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);    for (j=1;j<=n;j++) { 
       for(m=1; (m<= maxwav); m++){      for (i=1;i<j;i++) { 
         if (mint[m][i]==99 || anint[m][i]==9999) s[m][i]=-1;          sum=a[i][j]; 
         if(s[m][i] >0){        for (k=1;k<i;k++) sum -= a[i][k]*a[k][j]; 
           if (s[m][i] == nlstate+1) {        a[i][j]=sum; 
             if(agedc[i]>0)      } 
               if(moisdc[i]!=99 && andc[i]!=9999)      big=0.0; 
               agev[m][i]=agedc[i];      for (i=j;i<=n;i++) { 
             else{        sum=a[i][j]; 
               printf("Warning negative age at death: %d line:%d\n",num[i],i);        for (k=1;k<j;k++) 
               agev[m][i]=-1;          sum -= a[i][k]*a[k][j]; 
             }        a[i][j]=sum; 
           }        if ( (dum=vv[i]*fabs(sum)) >= big) { 
           else if(s[m][i] !=9){ /* Should no more exist */          big=dum; 
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);          imax=i; 
             if(mint[m][i]==99 || anint[m][i]==9999){        } 
               agev[m][i]=1;      } 
               /* printf("i=%d m=%d agev=%lf \n",i,m, agev[m][i]);    */      if (j != imax) { 
             }        for (k=1;k<=n;k++) { 
             else if(agev[m][i] <agemin){          dum=a[imax][k]; 
               agemin=agev[m][i];          a[imax][k]=a[j][k]; 
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/          a[j][k]=dum; 
             }        } 
             else if(agev[m][i] >agemax){        *d = -(*d); 
               agemax=agev[m][i];        vv[imax]=vv[j]; 
              /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/      } 
             }      indx[j]=imax; 
             /*agev[m][i]=anint[m][i]-annais[i];*/      if (a[j][j] == 0.0) a[j][j]=TINY; 
             /*   agev[m][i] = age[i]+2*m;*/      if (j != n) { 
           }        dum=1.0/(a[j][j]); 
           else { /* =9 */        for (i=j+1;i<=n;i++) a[i][j] *= dum; 
             agev[m][i]=1;      } 
             s[m][i]=-1;    } 
           }    free_vector(vv,1,n);  /* Doesn't work */
         }  ;
         else /*= 0 Unknown */  } 
           agev[m][i]=1;  
       }  void lubksb(double **a, int n, int *indx, double b[]) 
      { 
     }    int i,ii=0,ip,j; 
     for (i=1; i<=imx; i++)  {    double sum; 
       for(m=1; (m<= maxwav); m++){   
         if (s[m][i] > (nlstate+ndeath)) {    for (i=1;i<=n;i++) { 
           printf("Error: Wrong value in nlstate or ndeath\n");        ip=indx[i]; 
           goto end;      sum=b[ip]; 
         }      b[ip]=b[i]; 
       }      if (ii) 
     }        for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j]; 
       else if (sum) ii=i; 
 printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);      b[i]=sum; 
     } 
     free_vector(severity,1,maxwav);    for (i=n;i>=1;i--) { 
     free_imatrix(outcome,1,maxwav+1,1,n);      sum=b[i]; 
     free_vector(moisnais,1,n);      for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j]; 
     free_vector(annais,1,n);      b[i]=sum/a[i][i]; 
     free_matrix(mint,1,maxwav,1,n);    } 
     free_matrix(anint,1,maxwav,1,n);  } 
     free_vector(moisdc,1,n);  
     free_vector(andc,1,n);  /************ Frequencies ********************/
   void  freqsummary(char fileres[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, int *Tvaraff, int **nbcode, int *ncodemax,double **mint,double **anint, char strstart[])
      {  /* Some frequencies */
     wav=ivector(1,imx);    
     dh=imatrix(1,lastpass-firstpass+1,1,imx);    int i, m, jk, k1,i1, j1, bool, z1,z2,j;
     mw=imatrix(1,lastpass-firstpass+1,1,imx);    int first;
        double ***freq; /* Frequencies */
     /* Concatenates waves */    double *pp, **prop;
       concatwav(wav, dh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);    double pos,posprop, k2, dateintsum=0,k2cpt=0;
     FILE *ficresp;
     char fileresp[FILENAMELENGTH];
 Tcode=ivector(1,100);    
    nbcode=imatrix(1,nvar,1,8);      pp=vector(1,nlstate);
    ncodemax[1]=1;    prop=matrix(1,nlstate,iagemin,iagemax+3);
    if (cptcovn > 0) tricode(Tvar,nbcode,imx);    strcpy(fileresp,"p");
      strcat(fileresp,fileres);
    codtab=imatrix(1,100,1,10);    if((ficresp=fopen(fileresp,"w"))==NULL) {
    h=0;      printf("Problem with prevalence resultfile: %s\n", fileresp);
    m=pow(2,cptcovn);      fprintf(ficlog,"Problem with prevalence resultfile: %s\n", fileresp);
        exit(0);
    for(k=1;k<=cptcovn; k++){    }
      for(i=1; i <=(m/pow(2,k));i++){    freq= ma3x(-5,nlstate+ndeath,-5,nlstate+ndeath,iagemin,iagemax+3);
        for(j=1; j <= ncodemax[k]; j++){    j1=0;
          for(cpt=1; cpt <=(m/pow(2,cptcovn+1-k)); cpt++){    
            h++;    j=cptcoveff;
            if (h>m) h=1;codtab[h][k]=j;    if (cptcovn<1) {j=1;ncodemax[1]=1;}
          }  
        }    first=1;
      }  
    }    for(k1=1; k1<=j;k1++){
       for(i1=1; i1<=ncodemax[k1];i1++){
    /*for(i=1; i <=m ;i++){        j1++;
      for(k=1; k <=cptcovn; k++){        /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);
        printf("i=%d k=%d %d ",i,k,codtab[i][k]);          scanf("%d", i);*/
      }        for (i=-5; i<=nlstate+ndeath; i++)  
      printf("\n");          for (jk=-5; jk<=nlstate+ndeath; jk++)  
    }            for(m=iagemin; m <= iagemax+3; m++)
   scanf("%d",i);*/              freq[i][jk][m]=0;
      
    /* Calculates basic frequencies. Computes observed prevalence at single age      for (i=1; i<=nlstate; i++)  
        and prints on file fileres'p'. */        for(m=iagemin; m <= iagemax+3; m++)
   freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax);          prop[i][m]=0;
         
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */        dateintsum=0;
     oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */        k2cpt=0;
     newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */        for (i=1; i<=imx; i++) {
     savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */          bool=1;
     oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */          if  (cptcovn>0) {
                for (z1=1; z1<=cptcoveff; z1++) 
     /* For Powell, parameters are in a vector p[] starting at p[1]              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */                bool=0;
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */          }
     /*scanf("%d",i);*/          if (bool==1){
     mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);            for(m=firstpass; m<=lastpass; m++){
               k2=anint[m][i]+(mint[m][i]/12.);
                  /*if ((k2>=dateprev1) && (k2<=dateprev2)) {*/
     /*--------- results files --------------*/                if(agev[m][i]==0) agev[m][i]=iagemax+1;
     fprintf(ficres,"\ntitle=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate, ndeath, maxwav, mle,weightopt,model);                if(agev[m][i]==1) agev[m][i]=iagemax+2;
                    if (s[m][i]>0 && s[m][i]<=nlstate) prop[s[m][i]][(int)agev[m][i]] += weight[i];
    jk=1;                if (m<lastpass) {
    fprintf(ficres,"# Parameters\n");                  freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];
    printf("# Parameters\n");                  freq[s[m][i]][s[m+1][i]][iagemax+3] += weight[i];
    for(i=1,jk=1; i <=nlstate; i++){                }
      for(k=1; k <=(nlstate+ndeath); k++){                
        if (k != i)                if ((agev[m][i]>1) && (agev[m][i]< (iagemax+3))) {
          {                  dateintsum=dateintsum+k2;
            printf("%d%d ",i,k);                  k2cpt++;
            fprintf(ficres,"%1d%1d ",i,k);                }
            for(j=1; j <=ncovmodel; j++){                /*}*/
              printf("%f ",p[jk]);            }
              fprintf(ficres,"%f ",p[jk]);          }
              jk++;        }
            }         
            printf("\n");        /*      fprintf(ficresp, "#Count between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
            fprintf(ficres,"\n");  fprintf(ficresp, "#Local time at start: %s", strstart);
          }        if  (cptcovn>0) {
      }          fprintf(ficresp, "\n#********** Variable "); 
    }          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresp, "**********\n#");
     /* Computing hessian and covariance matrix */        }
     ftolhess=ftol; /* Usually correct */        for(i=1; i<=nlstate;i++) 
     hesscov(matcov, p, npar, delti, ftolhess, func);          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);
     fprintf(ficres,"# Scales\n");        fprintf(ficresp, "\n");
     printf("# Scales\n");        
      for(i=1,jk=1; i <=nlstate; i++){        for(i=iagemin; i <= iagemax+3; i++){
       for(j=1; j <=nlstate+ndeath; j++){          if(i==iagemax+3){
         if (j!=i) {            fprintf(ficlog,"Total");
           fprintf(ficres,"%1d%1d",i,j);          }else{
           printf("%1d%1d",i,j);            if(first==1){
           for(k=1; k<=ncovmodel;k++){              first=0;
             printf(" %.5e",delti[jk]);              printf("See log file for details...\n");
             fprintf(ficres," %.5e",delti[jk]);            }
             jk++;            fprintf(ficlog,"Age %d", i);
           }          }
           printf("\n");          for(jk=1; jk <=nlstate ; jk++){
           fprintf(ficres,"\n");            for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)
         }              pp[jk] += freq[jk][m][i]; 
       }          }
       }          for(jk=1; jk <=nlstate ; jk++){
                for(m=-1, pos=0; m <=0 ; m++)
     k=1;              pos += freq[jk][m][i];
     fprintf(ficres,"# Covariance\n");            if(pp[jk]>=1.e-10){
     printf("# Covariance\n");              if(first==1){
     for(i=1;i<=npar;i++){              printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
       /*  if (k>nlstate) k=1;              }
       i1=(i-1)/(ncovmodel*nlstate)+1;              fprintf(ficlog," %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
       fprintf(ficres,"%s%d%d",alph[k],i1,tab[i]);            }else{
       printf("%s%d%d",alph[k],i1,tab[i]);*/              if(first==1)
       fprintf(ficres,"%3d",i);                printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
       printf("%3d",i);              fprintf(ficlog," %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
       for(j=1; j<=i;j++){            }
         fprintf(ficres," %.5e",matcov[i][j]);          }
         printf(" %.5e",matcov[i][j]);  
       }          for(jk=1; jk <=nlstate ; jk++){
       fprintf(ficres,"\n");            for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)
       printf("\n");              pp[jk] += freq[jk][m][i];
       k++;          }       
     }          for(jk=1,pos=0,posprop=0; jk <=nlstate ; jk++){
                pos += pp[jk];
     while((c=getc(ficpar))=='#' && c!= EOF){            posprop += prop[jk][i];
       ungetc(c,ficpar);          }
       fgets(line, MAXLINE, ficpar);          for(jk=1; jk <=nlstate ; jk++){
       puts(line);            if(pos>=1.e-5){
       fputs(line,ficparo);              if(first==1)
     }                printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
     ungetc(c,ficpar);              fprintf(ficlog," %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
              }else{
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);              if(first==1)
                    printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     if (fage <= 2) {              fprintf(ficlog," %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
       bage = agemin;            }
       fage = agemax;            if( i <= iagemax){
     }              if(pos>=1.e-5){
                 fprintf(ficresp," %d %.5f %.0f %.0f",i,prop[jk][i]/posprop, prop[jk][i],posprop);
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");                /*probs[i][jk][j1]= pp[jk]/pos;*/
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);                /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/
 /*------------ gnuplot -------------*/              }
 chdir(pathcd);              else
   if((ficgp=fopen("graph.plt","w"))==NULL) {                fprintf(ficresp," %d NaNq %.0f %.0f",i,prop[jk][i],posprop);
     printf("Problem with file graph.gp");goto end;            }
   }          }
 #ifdef windows          
   fprintf(ficgp,"cd \"%s\" \n",pathc);          for(jk=-1; jk <=nlstate+ndeath; jk++)
 #endif            for(m=-1; m <=nlstate+ndeath; m++)
 m=pow(2,cptcovn);              if(freq[jk][m][i] !=0 ) {
                if(first==1)
  /* 1eme*/                printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);
   for (cpt=1; cpt<= nlstate ; cpt ++) {                fprintf(ficlog," %d%d=%.0f",jk,m,freq[jk][m][i]);
    for (k1=1; k1<= m ; k1 ++) {              }
           if(i <= iagemax)
 #ifdef windows            fprintf(ficresp,"\n");
     fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"vpl%s\" every :::%d::%d u 1:2 \"\%%lf",agemin,fage,fileres,k1-1,k1-1);          if(first==1)
 #endif            printf("Others in log...\n");
 #ifdef unix          fprintf(ficlog,"\n");
 fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nplot [%.f:%.f] \"vpl%s\" u 1:2 \"\%%lf",agemin,fage,fileres);        }
 #endif      }
     }
 for (i=1; i<= nlstate ; i ++) {    dateintmean=dateintsum/k2cpt; 
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");   
   else fprintf(ficgp," \%%*lf (\%%*lf)");    fclose(ficresp);
 }    free_ma3x(freq,-5,nlstate+ndeath,-5,nlstate+ndeath, iagemin, iagemax+3);
     fprintf(ficgp,"\" t\"Stationary prevalence\" w l 0,\"vpl%s\" every :::%d::%d u 1:($2+2*$3) \"\%%lf",fileres,k1-1,k1-1);    free_vector(pp,1,nlstate);
     for (i=1; i<= nlstate ; i ++) {    free_matrix(prop,1,nlstate,iagemin, iagemax+3);
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");    /* End of Freq */
   else fprintf(ficgp," \%%*lf (\%%*lf)");  }
 }  
   fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"vpl%s\" every :::%d::%d u 1:($2-2*$3) \"\%%lf",fileres,k1-1,k1-1);  /************ Prevalence ********************/
      for (i=1; i<= nlstate ; i ++) {  void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass)
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");  {  
   else fprintf(ficgp," \%%*lf (\%%*lf)");    /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people
 }         in each health status at the date of interview (if between dateprev1 and dateprev2).
      fprintf(ficgp,"\" t\"\" w l 1,\"p%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",fileres,k1-1,k1-1,2+4*(cpt-1));       We still use firstpass and lastpass as another selection.
 #ifdef unix    */
 fprintf(ficgp,"\nset ter gif small size 400,300");   
 #endif    int i, m, jk, k1, i1, j1, bool, z1,z2,j;
 fprintf(ficgp,"\nset out \"v%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);    double ***freq; /* Frequencies */
    }    double *pp, **prop;
   }    double pos,posprop; 
   /*2 eme*/    double  y2; /* in fractional years */
     int iagemin, iagemax;
   for (k1=1; k1<= m ; k1 ++) {  
     fprintf(ficgp,"set ylabel \"Years\" \nset ter gif small size 400,300\nplot [%.f:%.f] ",agemin,fage);    iagemin= (int) agemin;
        iagemax= (int) agemax;
     for (i=1; i<= nlstate+1 ; i ++) {    /*pp=vector(1,nlstate);*/
       k=2*i;    prop=matrix(1,nlstate,iagemin,iagemax+3); 
       fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:2 \"\%%lf",fileres,k1-1,k1-1);    /*  freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);*/
       for (j=1; j<= nlstate+1 ; j ++) {    j1=0;
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");    
   else fprintf(ficgp," \%%*lf (\%%*lf)");    j=cptcoveff;
 }      if (cptcovn<1) {j=1;ncodemax[1]=1;}
       if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");    
       else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);    for(k1=1; k1<=j;k1++){
     fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",fileres,k1-1,k1-1);      for(i1=1; i1<=ncodemax[k1];i1++){
       for (j=1; j<= nlstate+1 ; j ++) {        j1++;
         if (j==i) fprintf(ficgp," \%%lf (\%%lf)");        
         else fprintf(ficgp," \%%*lf (\%%*lf)");        for (i=1; i<=nlstate; i++)  
 }            for(m=iagemin; m <= iagemax+3; m++)
       fprintf(ficgp,"\" t\"\" w l 0,");            prop[i][m]=0.0;
      fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",fileres,k1-1,k1-1);       
       for (j=1; j<= nlstate+1 ; j ++) {        for (i=1; i<=imx; i++) { /* Each individual */
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");          bool=1;
   else fprintf(ficgp," \%%*lf (\%%*lf)");          if  (cptcovn>0) {
 }              for (z1=1; z1<=cptcoveff; z1++) 
       if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
       else fprintf(ficgp,"\" t\"\" w l 0,");                bool=0;
     }          } 
     fprintf(ficgp,"\nset out \"e%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),k1);          if (bool==1) { 
   }            for(m=firstpass; m<=lastpass; m++){/* Other selection (we can limit to certain interviews*/
                y2=anint[m][i]+(mint[m][i]/12.); /* Fractional date in year */
   /*3eme*/              if ((y2>=dateprev1) && (y2<=dateprev2)) { /* Here is the main selection (fractional years) */
                 if(agev[m][i]==0) agev[m][i]=iagemax+1;
   for (k1=1; k1<= m ; k1 ++) {                if(agev[m][i]==1) agev[m][i]=iagemax+2;
     for (cpt=1; cpt<= nlstate ; cpt ++) {                if((int)agev[m][i] <iagemin || (int)agev[m][i] >iagemax+3) printf("Error on individual =%d agev[m][i]=%f m=%d\n",i, agev[m][i],m); 
       k=2+nlstate*(cpt-1);                if (s[m][i]>0 && s[m][i]<=nlstate) { 
       fprintf(ficgp,"set ter gif small size 400,300\nplot [%.f:%.f] \"e%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",agemin,fage,fileres,k1-1,k1-1,k,cpt);                  /*if(i>4620) printf(" i=%d m=%d s[m][i]=%d (int)agev[m][i]=%d weight[i]=%f prop=%f\n",i,m,s[m][i],(int)agev[m][m],weight[i],prop[s[m][i]][(int)agev[m][i]]);*/
       for (i=1; i< nlstate ; i ++) {                  prop[s[m][i]][(int)agev[m][i]] += weight[i];
         fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",fileres,k1-1,k1-1,k+i,cpt,i+1);                  prop[s[m][i]][iagemax+3] += weight[i]; 
       }                } 
       fprintf(ficgp,"\nset out \"exp%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);              }
     }            } /* end selection of waves */
   }          }
          }
   /* CV preval stat */        for(i=iagemin; i <= iagemax+3; i++){  
   for (k1=1; k1<= m ; k1 ++) {          
     for (cpt=1; cpt<nlstate ; cpt ++) {          for(jk=1,posprop=0; jk <=nlstate ; jk++) { 
       k=3;            posprop += prop[jk][i]; 
       fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",agemin,agemax,fileres,k1,k+cpt+1,k+1);          } 
       for (i=1; i< nlstate ; i ++)  
         fprintf(ficgp,"+$%d",k+i+1);          for(jk=1; jk <=nlstate ; jk++){     
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);            if( i <=  iagemax){ 
                    if(posprop>=1.e-5){ 
       l=3+(nlstate+ndeath)*cpt;                probs[i][jk][j1]= prop[jk][i]/posprop;
       fprintf(ficgp,",\"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",fileres,k1,l+cpt+1,l+1);              } 
       for (i=1; i< nlstate ; i ++) {            } 
         l=3+(nlstate+ndeath)*cpt;          }/* end jk */ 
         fprintf(ficgp,"+$%d",l+i+1);        }/* end i */ 
       }      } /* end i1 */
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);      } /* end k1 */
       fprintf(ficgp,"set out \"p%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);    
     }    /*  free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);*/
   }    /*free_vector(pp,1,nlstate);*/
     free_matrix(prop,1,nlstate, iagemin,iagemax+3);
   /* proba elementaires */  }  /* End of prevalence */
   for(i=1,jk=1; i <=nlstate; i++){  
     for(k=1; k <=(nlstate+ndeath); k++){  /************* Waves Concatenation ***************/
       if (k != i) {  
         /*  fprintf(ficgp,"%1d%1d ",i,k);*/  void  concatwav(int wav[], int **dh, int **bh,  int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)
         for(j=1; j <=ncovmodel; j++){  {
           fprintf(ficgp,"%s%1d%1d=%f ",alph[j],i,k,p[jk]);    /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.
           jk++;       Death is a valid wave (if date is known).
           fprintf(ficgp,"\n");       mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i
         }       dh[m][i] or dh[mw[mi][i]][i] is the delay between two effective waves m=mw[mi][i]
       }       and mw[mi+1][i]. dh depends on stepm.
     }       */
   }  
   for(jk=1; jk <=m; jk++) {    int i, mi, m;
   fprintf(ficgp,"\nset ter gif small size 400,300\nset log y\nplot  [%.f:%.f] ",agemin,agemax);    /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;
   for(i=1; i <=nlstate; i++) {       double sum=0., jmean=0.;*/
     for(k=1; k <=(nlstate+ndeath); k++){    int first;
       if (k != i) {    int j, k=0,jk, ju, jl;
         fprintf(ficgp," exp(a%d%d+b%d%d*x",i,k,i,k);    double sum=0.;
         for(j=3; j <=ncovmodel; j++)    first=0;
           fprintf(ficgp,"+%s%d%d*%d",alph[j],i,k,nbcode[Tvar[j-2]][codtab[jk][j-2]]);    jmin=1e+5;
         fprintf(ficgp,")/(1");    jmax=-1;
         for(k1=1; k1 <=(nlstate+ndeath); k1++)    jmean=0.;
           if (k1 != i) {    for(i=1; i<=imx; i++){
             fprintf(ficgp,"+exp(a%d%d+b%d%d*x",i,k1,i,k1);      mi=0;
             for(j=3; j <=ncovmodel; j++)      m=firstpass;
               fprintf(ficgp,"+%s%d%d*%d",alph[j],i,k,nbcode[Tvar[j-2]][codtab[jk][j-2]]);      while(s[m][i] <= nlstate){
             fprintf(ficgp,")");        if(s[m][i]>=1 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5)
           }          mw[++mi][i]=m;
         fprintf(ficgp,") t \"p%d%d\" ", i,k);        if(m >=lastpass)
       if ((i+k)!= (nlstate*2+ndeath)) fprintf(ficgp,",");          break;
       }        else
     }          m++;
   }      }/* end while */
 fprintf(ficgp,"\nset out \"pe%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),jk);        if (s[m][i] > nlstate){
   }        mi++;     /* Death is another wave */
   fclose(ficgp);        /* if(mi==0)  never been interviewed correctly before death */
               /* Only death is a correct wave */
 chdir(path);        mw[mi][i]=m;
     free_matrix(agev,1,maxwav,1,imx);      }
     free_ivector(wav,1,imx);  
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);      wav[i]=mi;
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);      if(mi==0){
            nbwarn++;
     free_imatrix(s,1,maxwav+1,1,n);        if(first==0){
              printf("Warning! None valid information for:%ld line=%d (skipped) and may be others, see log file\n",num[i],i);
              first=1;
     free_ivector(num,1,n);        }
     free_vector(agedc,1,n);        if(first==1){
     free_vector(weight,1,n);          fprintf(ficlog,"Warning! None valid information for:%ld line=%d (skipped)\n",num[i],i);
     /*free_matrix(covar,1,NCOVMAX,1,n);*/        }
     fclose(ficparo);      } /* end mi==0 */
     fclose(ficres);    } /* End individuals */
    }  
        for(i=1; i<=imx; i++){
    /*________fin mle=1_________*/      for(mi=1; mi<wav[i];mi++){
            if (stepm <=0)
           dh[mi][i]=1;
          else{
     /* No more information from the sample is required now */          if (s[mw[mi+1][i]][i] > nlstate) { /* A death */
   /* Reads comments: lines beginning with '#' */            if (agedc[i] < 2*AGESUP) {
   while((c=getc(ficpar))=='#' && c!= EOF){              j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12); 
     ungetc(c,ficpar);              if(j==0) j=1;  /* Survives at least one month after exam */
     fgets(line, MAXLINE, ficpar);              else if(j<0){
     puts(line);                nberr++;
     fputs(line,ficparo);                printf("Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   }                j=1; /* Temporary Dangerous patch */
   ungetc(c,ficpar);                printf("   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
                  fprintf(ficlog,"Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);                fprintf(ficlog,"   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
   printf("agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax, bage, fage);              }
   fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);              k=k+1;
 /*--------- index.htm --------*/              if (j >= jmax) jmax=j;
               if (j <= jmin) jmin=j;
   if((fichtm=fopen("index.htm","w"))==NULL)    {              sum=sum+j;
     printf("Problem with index.htm \n");goto end;              /*if (j<0) printf("j=%d num=%d \n",j,i);*/
   }              /*    printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
             }
  fprintf(fichtm,"<body><ul> Imach, Version 0.63<hr> <li>Outputs files<br><br>\n          }
         - Observed prevalence in each state: <a href=\"p%s\">p%s</a> <br>\n          else{
 - Estimated parameters and the covariance matrix: <a href=\"%s\">%s</a> <br>            j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));
         - Stationary prevalence in each state: <a href=\"pl%s\">pl%s</a> <br>  /*        if (j<0) printf("%d %lf %lf %d %d %d\n", i,agev[mw[mi+1][i]][i], agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]); */
         - Transition probabilities: <a href=\"pij%s\">pij%s</a><br>  
         - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>            k=k+1;
         - Life expectancies by age and initial health status: <a href=\"e%s\">e%s</a> <br>            if (j >= jmax) jmax=j;
         - Variances of life expectancies by age and initial health status: <a href=\"v%s\">v%s</a><br>            else if (j <= jmin)jmin=j;
         - Health expectancies with their variances: <a href=\"t%s\">t%s</a> <br>            /*        if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */
         - Standard deviation of stationary prevalences: <a href=\"vpl%s\">vpl%s</a> <br><br>",fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres);            /*printf("%d %lf %d %d %d\n", i,agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);*/
             if(j<0){
  fprintf(fichtm," <li>Graphs</li>\n<p>");              nberr++;
               printf("Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
  m=cptcovn;              fprintf(ficlog,"Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
  if (cptcovn < 1) {m=1;ncodemax[1]=1;}            }
             sum=sum+j;
  j1=0;          }
  for(k1=1; k1<=m;k1++){          jk= j/stepm;
    for(i1=1; i1<=ncodemax[k1];i1++){          jl= j -jk*stepm;
        j1++;          ju= j -(jk+1)*stepm;
        if (cptcovn > 0) {          if(mle <=1){ /* only if we use a the linear-interpoloation pseudo-likelihood */
          fprintf(fichtm,"<hr>************ Results for covariates");            if(jl==0){
          for (cpt=1; cpt<=cptcovn;cpt++)              dh[mi][i]=jk;
            fprintf(fichtm," V%d=%d ",Tvar[cpt],nbcode[Tvar[cpt]][codtab[j1][cpt]]);              bh[mi][i]=0;
          fprintf(fichtm," ************\n<hr>");            }else{ /* We want a negative bias in order to only have interpolation ie
        }                    * at the price of an extra matrix product in likelihood */
        fprintf(fichtm,"<br>- Probabilities: pe%s%d.gif<br>              dh[mi][i]=jk+1;
 <img src=\"pe%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);                  bh[mi][i]=ju;
        for(cpt=1; cpt<nlstate;cpt++){            }
          fprintf(fichtm,"<br>- Prevalence of disability : p%s%d%d.gif<br>          }else{
 <img src=\"p%s%d%d.gif\">",strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);            if(jl <= -ju){
        }              dh[mi][i]=jk;
     for(cpt=1; cpt<=nlstate;cpt++) {              bh[mi][i]=jl;       /* bias is positive if real duration
        fprintf(fichtm,"<br>- Observed and stationary prevalence (with confident                                   * is higher than the multiple of stepm and negative otherwise.
 interval) in state (%d): v%s%d%d.gif <br>                                   */
 <img src=\"v%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);              }
      }            else{
      for(cpt=1; cpt<=nlstate;cpt++) {              dh[mi][i]=jk+1;
         fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): exp%s%d%d.gif <br>              bh[mi][i]=ju;
 <img src=\"exp%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);            }
      }            if(dh[mi][i]==0){
      fprintf(fichtm,"\n<br>- Total life expectancy by age and              dh[mi][i]=1; /* At least one step */
 health expectancies in states (1) and (2): e%s%d.gif<br>              bh[mi][i]=ju; /* At least one step */
 <img src=\"e%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);              /*  printf(" bh=%d ju=%d jl=%d dh=%d jk=%d stepm=%d %d\n",bh[mi][i],ju,jl,dh[mi][i],jk,stepm,i);*/
 fprintf(fichtm,"\n</body>");            }
    }          } /* end if mle */
  }        }
 fclose(fichtm);      } /* end wave */
     }
   /*--------------- Prevalence limit --------------*/    jmean=sum/k;
      printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);
   strcpy(filerespl,"pl");    fprintf(ficlog,"Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);
   strcat(filerespl,fileres);   }
   if((ficrespl=fopen(filerespl,"w"))==NULL) {  
     printf("Problem with Prev limit resultfile: %s\n", filerespl);goto end;  /*********** Tricode ****************************/
   }  void tricode(int *Tvar, int **nbcode, int imx)
   printf("Computing prevalence limit: result on file '%s' \n", filerespl);  {
   fprintf(ficrespl,"#Prevalence limit\n");    
   fprintf(ficrespl,"#Age ");    int Ndum[20],ij=1, k, j, i, maxncov=19;
   for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);    int cptcode=0;
   fprintf(ficrespl,"\n");    cptcoveff=0; 
     
   prlim=matrix(1,nlstate,1,nlstate);    for (k=0; k<maxncov; k++) Ndum[k]=0;
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    for (k=1; k<=7; k++) ncodemax[k]=0;
   oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */  
   newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    for (j=1; j<=(cptcovn+2*cptcovprod); j++) {
   savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */      for (i=1; i<=imx; i++) { /*reads the data file to get the maximum 
   oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */                                 modality*/ 
   k=0;        ij=(int)(covar[Tvar[j]][i]); /* ij is the modality of this individual*/
   agebase=agemin;        Ndum[ij]++; /*store the modality */
   agelim=agemax;        /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/
   ftolpl=1.e-10;        if (ij > cptcode) cptcode=ij; /* getting the maximum of covariable 
   i1=cptcovn;                                         Tvar[j]. If V=sex and male is 0 and 
   if (cptcovn < 1){i1=1;}                                         female is 1, then  cptcode=1.*/
       }
   for(cptcov=1;cptcov<=i1;cptcov++){  
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){      for (i=0; i<=cptcode; i++) {
         k=k+1;        if(Ndum[i]!=0) ncodemax[j]++; /* Nomber of modalities of the j th covariates. In fact ncodemax[j]=2 (dichotom. variables) but it can be more */
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/      }
         fprintf(ficrespl,"\n#****** ");  
         for(j=1;j<=cptcovn;j++)      ij=1; 
           fprintf(ficrespl,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);      for (i=1; i<=ncodemax[j]; i++) {
         fprintf(ficrespl,"******\n");        for (k=0; k<= maxncov; k++) {
                  if (Ndum[k] != 0) {
         for (age=agebase; age<=agelim; age++){            nbcode[Tvar[j]][ij]=k; 
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);            /* store the modality in an array. k is a modality. If we have model=V1+V1*sex then: nbcode[1][1]=0 ; nbcode[1][2]=1; nbcode[2][1]=0 ; nbcode[2][2]=1; */
           fprintf(ficrespl,"%.0f",age );            
           for(i=1; i<=nlstate;i++)            ij++;
           fprintf(ficrespl," %.5f", prlim[i][i]);          }
           fprintf(ficrespl,"\n");          if (ij > ncodemax[j]) break; 
         }        }  
       }      } 
     }    }  
   fclose(ficrespl);  
   /*------------- h Pij x at various ages ------------*/   for (k=0; k< maxncov; k++) Ndum[k]=0;
    
   strcpy(filerespij,"pij");  strcat(filerespij,fileres);   for (i=1; i<=ncovmodel-2; i++) { 
   if((ficrespij=fopen(filerespij,"w"))==NULL) {     /* Listing of all covariables in statement model to see if some covariates appear twice. For example, V1 appears twice in V1+V1*V2.*/
     printf("Problem with Pij resultfile: %s\n", filerespij);goto end;     ij=Tvar[i];
   }     Ndum[ij]++;
   printf("Computing pij: result on file '%s' \n", filerespij);   }
    
   stepsize=(int) (stepm+YEARM-1)/YEARM;   ij=1;
   if (stepm<=24) stepsize=2;   for (i=1; i<= maxncov; i++) {
      if((Ndum[i]!=0) && (i<=ncovcol)){
   agelim=AGESUP;       Tvaraff[ij]=i; /*For printing */
   hstepm=stepsize*YEARM; /* Every year of age */       ij++;
   hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */     }
     }
   k=0;   
   for(cptcov=1;cptcov<=i1;cptcov++){   cptcoveff=ij-1; /*Number of simple covariates*/
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){  }
       k=k+1;  
         fprintf(ficrespij,"\n#****** ");  /*********** Health Expectancies ****************/
         for(j=1;j<=cptcovn;j++)  
           fprintf(ficrespij,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);  void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij, int estepm,double delti[],double **matcov,char strstart[] )
         fprintf(ficrespij,"******\n");  
          {
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */    /* Health expectancies */
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */    int i, j, nhstepm, hstepm, h, nstepm, k, cptj;
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */    double age, agelim, hf;
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    double ***p3mat,***varhe;
           oldm=oldms;savm=savms;    double **dnewm,**doldm;
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);      double *xp;
           fprintf(ficrespij,"# Age");    double **gp, **gm;
           for(i=1; i<=nlstate;i++)    double ***gradg, ***trgradg;
             for(j=1; j<=nlstate+ndeath;j++)    int theta;
               fprintf(ficrespij," %1d-%1d",i,j);  
           fprintf(ficrespij,"\n");    varhe=ma3x(1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int) fage);
           for (h=0; h<=nhstepm; h++){    xp=vector(1,npar);
             fprintf(ficrespij,"%d %.0f %.0f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );    dnewm=matrix(1,nlstate*nlstate,1,npar);
             for(i=1; i<=nlstate;i++)    doldm=matrix(1,nlstate*nlstate,1,nlstate*nlstate);
               for(j=1; j<=nlstate+ndeath;j++)    
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);    fprintf(ficreseij,"# Local time at start: %s", strstart);
             fprintf(ficrespij,"\n");    fprintf(ficreseij,"# Health expectancies\n");
           }    fprintf(ficreseij,"# Age");
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    for(i=1; i<=nlstate;i++)
           fprintf(ficrespij,"\n");      for(j=1; j<=nlstate;j++)
         }        fprintf(ficreseij," %1d-%1d (SE)",i,j);
     }    fprintf(ficreseij,"\n");
   }  
     if(estepm < stepm){
   fclose(ficrespij);      printf ("Problem %d lower than %d\n",estepm, stepm);
     }
   /*---------- Health expectancies and variances ------------*/    else  hstepm=estepm;   
     /* We compute the life expectancy from trapezoids spaced every estepm months
   strcpy(filerest,"t");     * This is mainly to measure the difference between two models: for example
   strcat(filerest,fileres);     * if stepm=24 months pijx are given only every 2 years and by summing them
   if((ficrest=fopen(filerest,"w"))==NULL) {     * we are calculating an estimate of the Life Expectancy assuming a linear 
     printf("Problem with total LE resultfile: %s\n", filerest);goto end;     * progression in between and thus overestimating or underestimating according
   }     * to the curvature of the survival function. If, for the same date, we 
   printf("Computing Total LEs with variances: file '%s' \n", filerest);     * estimate the model with stepm=1 month, we can keep estepm to 24 months
      * to compare the new estimate of Life expectancy with the same linear 
      * hypothesis. A more precise result, taking into account a more precise
   strcpy(filerese,"e");     * curvature will be obtained if estepm is as small as stepm. */
   strcat(filerese,fileres);  
   if((ficreseij=fopen(filerese,"w"))==NULL) {    /* For example we decided to compute the life expectancy with the smallest unit */
     printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
   }       nhstepm is the number of hstepm from age to agelim 
   printf("Computing Health Expectancies: result on file '%s' \n", filerese);       nstepm is the number of stepm from age to agelin. 
        Look at hpijx to understand the reason of that which relies in memory size
  strcpy(fileresv,"v");       and note for a fixed period like estepm months */
   strcat(fileresv,fileres);    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
   if((ficresvij=fopen(fileresv,"w"))==NULL) {       survival function given by stepm (the optimization length). Unfortunately it
     printf("Problem with variance resultfile: %s\n", fileresv);exit(0);       means that if the survival funtion is printed only each two years of age and if
   }       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
   printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);       results. So we changed our mind and took the option of the best precision.
     */
   k=0;    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
   for(cptcov=1;cptcov<=i1;cptcov++){  
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){    agelim=AGESUP;
       k=k+1;    for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       fprintf(ficrest,"\n#****** ");      /* nhstepm age range expressed in number of stepm */
       for(j=1;j<=cptcovn;j++)      nstepm=(int) rint((agelim-age)*YEARM/stepm); 
         fprintf(ficrest,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);      /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
       fprintf(ficrest,"******\n");      /* if (stepm >= YEARM) hstepm=1;*/
       nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       fprintf(ficreseij,"\n#****** ");      p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       for(j=1;j<=cptcovn;j++)      gradg=ma3x(0,nhstepm,1,npar,1,nlstate*nlstate);
         fprintf(ficreseij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);      gp=matrix(0,nhstepm,1,nlstate*nlstate);
       fprintf(ficreseij,"******\n");      gm=matrix(0,nhstepm,1,nlstate*nlstate);
   
       fprintf(ficresvij,"\n#****** ");      /* Computed by stepm unit matrices, product of hstepm matrices, stored
       for(j=1;j<=cptcovn;j++)         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
         fprintf(ficresvij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);      hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);  
       fprintf(ficresvij,"******\n");   
   
       eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
       oldm=oldms;savm=savms;  
       evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k);        /* Computing  Variances of health expectancies */
       vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);  
       oldm=oldms;savm=savms;       for(theta=1; theta <=npar; theta++){
       varevsij(fileres, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);        for(i=1; i<=npar; i++){ 
                xp[i] = x[i] + (i==theta ?delti[theta]:0);
       fprintf(ficrest,"#Total LEs with variances: e.. (std) ");        }
       for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
       fprintf(ficrest,"\n");    
                cptj=0;
       hf=1;        for(j=1; j<= nlstate; j++){
       if (stepm >= YEARM) hf=stepm/YEARM;          for(i=1; i<=nlstate; i++){
       epj=vector(1,nlstate+1);            cptj=cptj+1;
       for(age=bage; age <=fage ;age++){            for(h=0, gp[h][cptj]=0.; h<=nhstepm-1; h++){
         prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);              gp[h][cptj] = (p3mat[i][j][h]+p3mat[i][j][h+1])/2.;
         fprintf(ficrest," %.0f",age);            }
         for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){          }
           for(i=1, epj[j]=0.;i <=nlstate;i++) {        }
             epj[j] += prlim[i][i]*hf*eij[i][j][(int)age];       
           }       
           epj[nlstate+1] +=epj[j];        for(i=1; i<=npar; i++) 
         }          xp[i] = x[i] - (i==theta ?delti[theta]:0);
         for(i=1, vepp=0.;i <=nlstate;i++)        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
           for(j=1;j <=nlstate;j++)        
             vepp += vareij[i][j][(int)age];        cptj=0;
         fprintf(ficrest," %.2f (%.2f)", epj[nlstate+1],hf*sqrt(vepp));        for(j=1; j<= nlstate; j++){
         for(j=1;j <=nlstate;j++){          for(i=1;i<=nlstate;i++){
           fprintf(ficrest," %.2f (%.2f)", epj[j],hf*sqrt(vareij[j][j][(int)age]));            cptj=cptj+1;
         }            for(h=0, gm[h][cptj]=0.; h<=nhstepm-1; h++){
         fprintf(ficrest,"\n");  
       }              gm[h][cptj] = (p3mat[i][j][h]+p3mat[i][j][h+1])/2.;
     }            }
   }          }
                }
  fclose(ficreseij);        for(j=1; j<= nlstate*nlstate; j++)
  fclose(ficresvij);          for(h=0; h<=nhstepm-1; h++){
   fclose(ficrest);            gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
   fclose(ficpar);          }
   free_vector(epj,1,nlstate+1);       } 
   /*  scanf("%d ",i); */     
   /* End theta */
   /*------- Variance limit prevalence------*/    
        trgradg =ma3x(0,nhstepm,1,nlstate*nlstate,1,npar);
 strcpy(fileresvpl,"vpl");  
   strcat(fileresvpl,fileres);       for(h=0; h<=nhstepm-1; h++)
   if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {        for(j=1; j<=nlstate*nlstate;j++)
     printf("Problem with variance prev lim resultfile: %s\n", fileresvpl);          for(theta=1; theta <=npar; theta++)
     exit(0);            trgradg[h][j][theta]=gradg[h][theta][j];
   }       
   printf("Computing Variance-covariance of Prevalence limit: file '%s' \n", fileresvpl);  
        for(i=1;i<=nlstate*nlstate;i++)
  k=0;        for(j=1;j<=nlstate*nlstate;j++)
  for(cptcov=1;cptcov<=i1;cptcov++){          varhe[i][j][(int)age] =0.;
    for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){  
      k=k+1;       printf("%d|",(int)age);fflush(stdout);
      fprintf(ficresvpl,"\n#****** ");       fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
      for(j=1;j<=cptcovn;j++)       for(h=0;h<=nhstepm-1;h++){
        fprintf(ficresvpl,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);        for(k=0;k<=nhstepm-1;k++){
      fprintf(ficresvpl,"******\n");          matprod2(dnewm,trgradg[h],1,nlstate*nlstate,1,npar,1,npar,matcov);
                matprod2(doldm,dnewm,1,nlstate*nlstate,1,npar,1,nlstate*nlstate,gradg[k]);
      varpl=matrix(1,nlstate,(int) bage, (int) fage);          for(i=1;i<=nlstate*nlstate;i++)
      oldm=oldms;savm=savms;            for(j=1;j<=nlstate*nlstate;j++)
      varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);              varhe[i][j][(int)age] += doldm[i][j]*hf*hf;
    }        }
  }      }
       /* Computing expectancies */
   fclose(ficresvpl);      for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++)
   /*---------- End : free ----------------*/          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
   free_matrix(varpl,1,nlstate,(int) bage, (int)fage);            eij[i][j][(int)age] += (p3mat[i][j][h]+p3mat[i][j][h+1])/2.0*hf;
              
   free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);  /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
   free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);  
            }
    
   free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);      fprintf(ficreseij,"%3.0f",age );
   free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);      cptj=0;
   free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);      for(i=1; i<=nlstate;i++)
   free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);        for(j=1; j<=nlstate;j++){
            cptj++;
   free_matrix(matcov,1,npar,1,npar);          fprintf(ficreseij," %9.4f (%.4f)", eij[i][j][(int)age], sqrt(varhe[cptj][cptj][(int)age]) );
   free_vector(delti,1,npar);        }
        fprintf(ficreseij,"\n");
   free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);     
       free_matrix(gm,0,nhstepm,1,nlstate*nlstate);
   printf("End of Imach\n");      free_matrix(gp,0,nhstepm,1,nlstate*nlstate);
   /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */      free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate*nlstate);
        free_ma3x(trgradg,0,nhstepm,1,nlstate*nlstate,1,npar);
   /* printf("Total time was %d Sec. %d uSec.\n", end_time.tv_sec -start_time.tv_sec, end_time.tv_usec -start_time.tv_usec);*/      free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   /*printf("Total time was %d uSec.\n", total_usecs);*/    }
   /*------ End -----------*/    printf("\n");
     fprintf(ficlog,"\n");
  end:  
 #ifdef windows    free_vector(xp,1,npar);
  chdir(pathcd);    free_matrix(dnewm,1,nlstate*nlstate,1,npar);
 #endif    free_matrix(doldm,1,nlstate*nlstate,1,nlstate*nlstate);
  system("wgnuplot ../gp37mgw/graph.plt");    free_ma3x(varhe,1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int)fage);
   }
 #ifdef windows  
   while (z[0] != 'q') {  /************ Variance ******************/
     chdir(pathcd);  void varevsij(char optionfilefiname[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, int estepm, int cptcov, int cptcod, int popbased, int mobilav, char strstart[])
     printf("\nType e to edit output files, c to start again, and q for exiting: ");  {
     scanf("%s",z);    /* Variance of health expectancies */
     if (z[0] == 'c') system("./imach");    /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/
     else if (z[0] == 'e') {    /* double **newm;*/
       chdir(path);    double **dnewm,**doldm;
       system("index.htm");    double **dnewmp,**doldmp;
     }    int i, j, nhstepm, hstepm, h, nstepm ;
     else if (z[0] == 'q') exit(0);    int k, cptcode;
   }    double *xp;
 #endif    double **gp, **gm;  /* for var eij */
 }    double ***gradg, ***trgradg; /*for var eij */
     double **gradgp, **trgradgp; /* for var p point j */
     double *gpp, *gmp; /* for var p point j */
     double **varppt; /* for var p point j nlstate to nlstate+ndeath */
     double ***p3mat;
     double age,agelim, hf;
     double ***mobaverage;
     int theta;
     char digit[4];
     char digitp[25];
   
     char fileresprobmorprev[FILENAMELENGTH];
   
     if(popbased==1){
       if(mobilav!=0)
         strcpy(digitp,"-populbased-mobilav-");
       else strcpy(digitp,"-populbased-nomobil-");
     }
     else 
       strcpy(digitp,"-stablbased-");
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     strcpy(fileresprobmorprev,"prmorprev"); 
     sprintf(digit,"%-d",ij);
     /*printf("DIGIT=%s, ij=%d ijr=%-d|\n",digit, ij,ij);*/
     strcat(fileresprobmorprev,digit); /* Tvar to be done */
     strcat(fileresprobmorprev,digitp); /* Popbased or not, mobilav or not */
     strcat(fileresprobmorprev,fileres);
     if((ficresprobmorprev=fopen(fileresprobmorprev,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobmorprev);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobmorprev);
     }
     printf("Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
    
     fprintf(ficlog,"Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
     fprintf(ficresprobmorprev, "#Local time at start: %s", strstart);
     fprintf(ficresprobmorprev,"# probabilities of dying before estepm=%d months for people of exact age and weighted probabilities w1*p1j+w2*p2j+... stand dev in()\n",estepm);
     fprintf(ficresprobmorprev,"# Age cov=%-d",ij);
     for(j=nlstate+1; j<=(nlstate+ndeath);j++){
       fprintf(ficresprobmorprev," p.%-d SE",j);
       for(i=1; i<=nlstate;i++)
         fprintf(ficresprobmorprev," w%1d p%-d%-d",i,i,j);
     }  
     fprintf(ficresprobmorprev,"\n");
     fprintf(ficgp,"\n# Routine varevsij");
     /* fprintf(fichtm, "#Local time at start: %s", strstart);*/
     fprintf(fichtm,"\n<li><h4> Computing probabilities of dying over estepm months as a weighted average (i.e global mortality independent of initial healh state)</h4></li>\n");
     fprintf(fichtm,"\n<br>%s  <br>\n",digitp);
   /*   } */
     varppt = matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
    fprintf(ficresvij, "#Local time at start: %s", strstart);
     fprintf(ficresvij,"# Variance and covariance of health expectancies e.j \n#  (weighted average of eij where weights are the stable prevalence in health states i\n");
     fprintf(ficresvij,"# Age");
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=nlstate;j++)
         fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);
     fprintf(ficresvij,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     dnewmp= matrix(nlstate+1,nlstate+ndeath,1,npar);
     doldmp= matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
   
     gradgp=matrix(1,npar,nlstate+1,nlstate+ndeath);
     gpp=vector(nlstate+1,nlstate+ndeath);
     gmp=vector(nlstate+1,nlstate+ndeath);
     trgradgp =matrix(nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
     /* For example we decided to compute the life expectancy with the smallest unit */
     /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
        nhstepm is the number of hstepm from age to agelim 
        nstepm is the number of stepm from age to agelin. 
        Look at hpijx to understand the reason of that which relies in memory size
        and note for a fixed period like k years */
     /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
        means that if the survival funtion is printed every two years of age and if
        you sum them up and add 1 year (area under the trapezoids) you won't get the same 
        results. So we changed our mind and took the option of the best precision.
     */
     hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       gradg=ma3x(0,nhstepm,1,npar,1,nlstate);
       gp=matrix(0,nhstepm,1,nlstate);
       gm=matrix(0,nhstepm,1,nlstate);
   
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient x + delta*/
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
   
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
     
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gp[h][j]=0.;i<=nlstate;i++)
               gp[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gpp[j]=0.; i<= nlstate; i++)
             gpp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(i=1; i<=npar; i++) /* Computes gradient x - delta */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
    
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
   
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gm[h][j]=0.;i<=nlstate;i++)
               gm[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gmp[j]=0.; i<= nlstate; i++)
            gmp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(j=1; j<= nlstate; j++) /* vareij */
           for(h=0; h<=nhstepm; h++){
             gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
           }
   
         for(j=nlstate+1; j<= nlstate+ndeath; j++){ /* var mu */
           gradgp[theta][j]= (gpp[j]-gmp[j])/2./delti[theta];
         }
   
       } /* End theta */
   
       trgradg =ma3x(0,nhstepm,1,nlstate,1,npar); /* veij */
   
       for(h=0; h<=nhstepm; h++) /* veij */
         for(j=1; j<=nlstate;j++)
           for(theta=1; theta <=npar; theta++)
             trgradg[h][j][theta]=gradg[h][theta][j];
   
       for(j=nlstate+1; j<=nlstate+ndeath;j++) /* mu */
         for(theta=1; theta <=npar; theta++)
           trgradgp[j][theta]=gradgp[theta][j];
     
   
       hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
       for(i=1;i<=nlstate;i++)
         for(j=1;j<=nlstate;j++)
           vareij[i][j][(int)age] =0.;
   
       for(h=0;h<=nhstepm;h++){
         for(k=0;k<=nhstepm;k++){
           matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);
           matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);
           for(i=1;i<=nlstate;i++)
             for(j=1;j<=nlstate;j++)
               vareij[i][j][(int)age] += doldm[i][j]*hf*hf;
         }
       }
     
       /* pptj */
       matprod2(dnewmp,trgradgp,nlstate+1,nlstate+ndeath,1,npar,1,npar,matcov);
       matprod2(doldmp,dnewmp,nlstate+1,nlstate+ndeath,1,npar,nlstate+1,nlstate+ndeath,gradgp);
       for(j=nlstate+1;j<=nlstate+ndeath;j++)
         for(i=nlstate+1;i<=nlstate+ndeath;i++)
           varppt[j][i]=doldmp[j][i];
       /* end ppptj */
       /*  x centered again */
       hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm,savm, ij);  
       prevalim(prlim,nlstate,x,age,oldm,savm,ftolpl,ij);
    
       if (popbased==1) {
         if(mobilav ==0){
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=probs[(int)age][i][ij];
         }else{ /* mobilav */ 
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=mobaverage[(int)age][i][ij];
         }
       }
                
       /* This for computing probability of death (h=1 means
          computed over hstepm (estepm) matrices product = hstepm*stepm months) 
          as a weighted average of prlim.
       */
       for(j=nlstate+1;j<=nlstate+ndeath;j++){
         for(i=1,gmp[j]=0.;i<= nlstate; i++) 
           gmp[j] += prlim[i][i]*p3mat[i][j][1]; 
       }    
       /* end probability of death */
   
       fprintf(ficresprobmorprev,"%3d %d ",(int) age, ij);
       for(j=nlstate+1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprobmorprev," %11.3e %11.3e",gmp[j], sqrt(varppt[j][j]));
         for(i=1; i<=nlstate;i++){
           fprintf(ficresprobmorprev," %11.3e %11.3e ",prlim[i][i],p3mat[i][j][1]);
         }
       } 
       fprintf(ficresprobmorprev,"\n");
   
       fprintf(ficresvij,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           fprintf(ficresvij," %.4f", vareij[i][j][(int)age]);
         }
       fprintf(ficresvij,"\n");
       free_matrix(gp,0,nhstepm,1,nlstate);
       free_matrix(gm,0,nhstepm,1,nlstate);
       free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);
       free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);
       free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     } /* End age */
     free_vector(gpp,nlstate+1,nlstate+ndeath);
     free_vector(gmp,nlstate+1,nlstate+ndeath);
     free_matrix(gradgp,1,npar,nlstate+1,nlstate+ndeath);
     free_matrix(trgradgp,nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     fprintf(ficgp,"\nset noparametric;set nolabel; set ter png small;set size 0.65, 0.65");
     /* for(j=nlstate+1; j<= nlstate+ndeath; j++){ *//* Only the first actually */
     fprintf(ficgp,"\n set log y; set nolog x;set xlabel \"Age\"; set ylabel \"Force of mortality (year-1)\";");
   /*   fprintf(ficgp,"\n plot \"%s\"  u 1:($3*%6.3f) not w l 1 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)*%6.3f) t \"95\%% interval\" w l 2 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)*%6.3f) not w l 2 ",fileresprobmorprev,YEARM/estepm); */
     fprintf(ficgp,"\n plot \"%s\"  u 1:($3) not w l 1 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)) t \"95\%% interval\" w l 2 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)) not w l 2 ",subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> File (multiple files are possible if covariates are present): <A href=\"%s\">%s</a>\n",subdirf(fileresprobmorprev),subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months. <br> <img src=\"%s%s.png\"> <br>\n", estepm,subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
     /*  fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months and then divided by estepm and multiplied by %.0f in order to have the probability to die over a year <br> <img src=\"varmuptjgr%s%s.png\"> <br>\n", stepm,YEARM,digitp,digit);
   */
   /*   fprintf(ficgp,"\nset out \"varmuptjgr%s%s%s.png\";replot;",digitp,optionfilefiname,digit); */
     fprintf(ficgp,"\nset out \"%s%s.png\";replot;\n",subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,nlstate);
     free_matrix(dnewm,1,nlstate,1,npar);
     free_matrix(doldmp,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     free_matrix(dnewmp,nlstate+1,nlstate+ndeath,1,npar);
     free_matrix(varppt,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficresprobmorprev);
     fflush(ficgp);
     fflush(fichtm); 
   }  /* end varevsij */
   
   /************ Variance of prevlim ******************/
   void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, char strstart[])
   {
     /* Variance of prevalence limit */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/
     double **newm;
     double **dnewm,**doldm;
     int i, j, nhstepm, hstepm;
     int k, cptcode;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double age,agelim;
     int theta;
     fprintf(ficresvpl, "#Local time at start: %s", strstart); 
     fprintf(ficresvpl,"# Standard deviation of stable prevalences \n");
     fprintf(ficresvpl,"# Age");
     for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %1d-%1d",i,i);
     fprintf(ficresvpl,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     
     hstepm=1*YEARM; /* Every year of age */
     hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       if (stepm >= YEARM) hstepm=1;
       nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
       gradg=matrix(1,npar,1,nlstate);
       gp=vector(1,nlstate);
       gm=vector(1,nlstate);
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient */
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gp[i] = prlim[i][i];
       
         for(i=1; i<=npar; i++) /* Computes gradient */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gm[i] = prlim[i][i];
   
         for(i=1;i<=nlstate;i++)
           gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];
       } /* End theta */
   
       trgradg =matrix(1,nlstate,1,npar);
   
       for(j=1; j<=nlstate;j++)
         for(theta=1; theta <=npar; theta++)
           trgradg[j][theta]=gradg[theta][j];
   
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] =0.;
       matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);
       matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */
   
       fprintf(ficresvpl,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));
       fprintf(ficresvpl,"\n");
       free_vector(gp,1,nlstate);
       free_vector(gm,1,nlstate);
       free_matrix(gradg,1,npar,1,nlstate);
       free_matrix(trgradg,1,nlstate,1,npar);
     } /* End age */
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,npar);
     free_matrix(dnewm,1,nlstate,1,nlstate);
   
   }
   
   /************ Variance of one-step probabilities  ******************/
   void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[])
   {
     int i, j=0,  i1, k1, l1, t, tj;
     int k2, l2, j1,  z1;
     int k=0,l, cptcode;
     int first=1, first1;
     double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp;
     double **dnewm,**doldm;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double **mu;
     double age,agelim, cov[NCOVMAX];
     double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */
     int theta;
     char fileresprob[FILENAMELENGTH];
     char fileresprobcov[FILENAMELENGTH];
     char fileresprobcor[FILENAMELENGTH];
   
     double ***varpij;
   
     strcpy(fileresprob,"prob"); 
     strcat(fileresprob,fileres);
     if((ficresprob=fopen(fileresprob,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprob);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob);
     }
     strcpy(fileresprobcov,"probcov"); 
     strcat(fileresprobcov,fileres);
     if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcov);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov);
     }
     strcpy(fileresprobcor,"probcor"); 
     strcat(fileresprobcor,fileres);
     if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcor);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor);
     }
     printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     fprintf(ficresprob, "#Local time at start: %s", strstart);
     fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n");
     fprintf(ficresprob,"# Age");
     fprintf(ficresprobcov, "#Local time at start: %s", strstart);
     fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n");
     fprintf(ficresprobcov,"# Age");
     fprintf(ficresprobcor, "#Local time at start: %s", strstart);
     fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n");
     fprintf(ficresprobcov,"# Age");
   
   
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprob," p%1d-%1d (SE)",i,j);
         fprintf(ficresprobcov," p%1d-%1d ",i,j);
         fprintf(ficresprobcor," p%1d-%1d ",i,j);
       }  
    /* fprintf(ficresprob,"\n");
     fprintf(ficresprobcov,"\n");
     fprintf(ficresprobcor,"\n");
    */
    xp=vector(1,npar);
     dnewm=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
     doldm=matrix(1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     mu=matrix(1,(nlstate)*(nlstate+ndeath), (int) bage, (int)fage);
     varpij=ma3x(1,nlstate*(nlstate+ndeath),1,nlstate*(nlstate+ndeath),(int) bage, (int) fage);
     first=1;
     fprintf(ficgp,"\n# Routine varprob");
     fprintf(fichtm,"\n<li><h4> Computing and drawing one step probabilities with their confidence intervals</h4></li>\n");
     fprintf(fichtm,"\n");
   
     fprintf(fichtm,"\n<li><h4> <a href=\"%s\">Matrix of variance-covariance of pairs of step probabilities (drawings)</a></h4></li>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\n<h4>Matrix of variance-covariance of pairs of step probabilities</h4>\n\
     file %s<br>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (p<inf>ij</inf>, p<inf>kl</inf>) are estimated\
   and drawn. It helps understanding how is the covariance between two incidences.\
    They are expressed in year<sup>-1</sup> in order to be less dependent of stepm.<br>\n");
     fprintf(fichtmcov,"\n<br> Contour plot corresponding to x'cov<sup>-1</sup>x = 4 (where x is the column vector (pij,pkl)) are drawn. \
   It can be understood this way: if pij and pkl where uncorrelated the (2x2) matrix of covariance \
   would have been (1/(var pij), 0 , 0, 1/(var pkl)), and the confidence interval would be 2 \
   standard deviations wide on each axis. <br>\
    Now, if both incidences are correlated (usual case) we diagonalised the inverse of the covariance matrix\
    and made the appropriate rotation to look at the uncorrelated principal directions.<br>\
   To be simple, these graphs help to understand the significativity of each parameter in relation to a second other one.<br> \n");
   
     cov[1]=1;
     tj=cptcoveff;
     if (cptcovn<1) {tj=1;ncodemax[1]=1;}
     j1=0;
     for(t=1; t<=tj;t++){
       for(i1=1; i1<=ncodemax[t];i1++){ 
         j1++;
         if  (cptcovn>0) {
           fprintf(ficresprob, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprob, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprob, "**********\n#\n");
           fprintf(ficresprobcov, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcov, "**********\n#\n");
           
           fprintf(ficgp, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficgp, " V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficgp, "**********\n#\n");
           
           
           fprintf(fichtmcov, "\n<hr  size=\"2\" color=\"#EC5E5E\">********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(fichtmcov, "**********\n<hr size=\"2\" color=\"#EC5E5E\">");
           
           fprintf(ficresprobcor, "\n#********** Variable ");    
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcor, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcor, "**********\n#");    
         }
         
         for (age=bage; age<=fage; age ++){ 
           cov[2]=age;
           for (k=1; k<=cptcovn;k++) {
             cov[2+k]=nbcode[Tvar[k]][codtab[j1][Tvar[k]]];
           }
           for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
           for (k=1; k<=cptcovprod;k++)
             cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
           
           gradg=matrix(1,npar,1,(nlstate)*(nlstate+ndeath));
           trgradg=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
           gp=vector(1,(nlstate)*(nlstate+ndeath));
           gm=vector(1,(nlstate)*(nlstate+ndeath));
       
           for(theta=1; theta <=npar; theta++){
             for(i=1; i<=npar; i++)
               xp[i] = x[i] + (i==theta ?delti[theta]:(double)0);
             
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             
             k=0;
             for(i=1; i<= (nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gp[k]=pmmij[i][j];
               }
             }
             
             for(i=1; i<=npar; i++)
               xp[i] = x[i] - (i==theta ?delti[theta]:(double)0);
       
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             k=0;
             for(i=1; i<=(nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gm[k]=pmmij[i][j];
               }
             }
        
             for(i=1; i<= (nlstate)*(nlstate+ndeath); i++) 
               gradg[theta][i]=(gp[i]-gm[i])/(double)2./delti[theta];  
           }
   
           for(j=1; j<=(nlstate)*(nlstate+ndeath);j++)
             for(theta=1; theta <=npar; theta++)
               trgradg[j][theta]=gradg[theta][j];
           
           matprod2(dnewm,trgradg,1,(nlstate)*(nlstate+ndeath),1,npar,1,npar,matcov); 
           matprod2(doldm,dnewm,1,(nlstate)*(nlstate+ndeath),1,npar,1,(nlstate)*(nlstate+ndeath),gradg);
           free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
           free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
   
           pmij(pmmij,cov,ncovmodel,x,nlstate);
           
           k=0;
           for(i=1; i<=(nlstate); i++){
             for(j=1; j<=(nlstate+ndeath);j++){
               k=k+1;
               mu[k][(int) age]=pmmij[i][j];
             }
           }
           for(i=1;i<=(nlstate)*(nlstate+ndeath);i++)
             for(j=1;j<=(nlstate)*(nlstate+ndeath);j++)
               varpij[i][j][(int)age] = doldm[i][j];
   
           /*printf("\n%d ",(int)age);
             for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             fprintf(ficlog,"%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             }*/
   
           fprintf(ficresprob,"\n%d ",(int)age);
           fprintf(ficresprobcov,"\n%d ",(int)age);
           fprintf(ficresprobcor,"\n%d ",(int)age);
   
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++)
             fprintf(ficresprob,"%11.3e (%11.3e) ",mu[i][(int) age],sqrt(varpij[i][i][(int)age]));
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             fprintf(ficresprobcov,"%11.3e ",mu[i][(int) age]);
             fprintf(ficresprobcor,"%11.3e ",mu[i][(int) age]);
           }
           i=0;
           for (k=1; k<=(nlstate);k++){
             for (l=1; l<=(nlstate+ndeath);l++){ 
               i=i++;
               fprintf(ficresprobcov,"\n%d %d-%d",(int)age,k,l);
               fprintf(ficresprobcor,"\n%d %d-%d",(int)age,k,l);
               for (j=1; j<=i;j++){
                 fprintf(ficresprobcov," %11.3e",varpij[i][j][(int)age]);
                 fprintf(ficresprobcor," %11.3e",varpij[i][j][(int) age]/sqrt(varpij[i][i][(int) age])/sqrt(varpij[j][j][(int)age]));
               }
             }
           }/* end of loop for state */
         } /* end of loop for age */
   
         /* Confidence intervalle of pij  */
         /*
           fprintf(ficgp,"\nset noparametric;unset label");
           fprintf(ficgp,"\nset log y;unset log x; set xlabel \"Age\";set ylabel \"probability (year-1)\"");
           fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
           fprintf(fichtm,"\n<br>Probability with  confidence intervals expressed in year<sup>-1</sup> :<a href=\"pijgr%s.png\">pijgr%s.png</A>, ",optionfilefiname,optionfilefiname);
           fprintf(fichtm,"\n<br><img src=\"pijgr%s.png\"> ",optionfilefiname);
           fprintf(ficgp,"\nset out \"pijgr%s.png\"",optionfilefiname);
           fprintf(ficgp,"\nplot \"%s\" every :::%d::%d u 1:2 \"\%%lf",k1,k2,xfilevarprob);
         */
   
         /* Drawing ellipsoids of confidence of two variables p(k1-l1,k2-l2)*/
         first1=1;
         for (k2=1; k2<=(nlstate);k2++){
           for (l2=1; l2<=(nlstate+ndeath);l2++){ 
             if(l2==k2) continue;
             j=(k2-1)*(nlstate+ndeath)+l2;
             for (k1=1; k1<=(nlstate);k1++){
               for (l1=1; l1<=(nlstate+ndeath);l1++){ 
                 if(l1==k1) continue;
                 i=(k1-1)*(nlstate+ndeath)+l1;
                 if(i<=j) continue;
                 for (age=bage; age<=fage; age ++){ 
                   if ((int)age %5==0){
                     v1=varpij[i][i][(int)age]/stepm*YEARM/stepm*YEARM;
                     v2=varpij[j][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     cv12=varpij[i][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     mu1=mu[i][(int) age]/stepm*YEARM ;
                     mu2=mu[j][(int) age]/stepm*YEARM;
                     c12=cv12/sqrt(v1*v2);
                     /* Computing eigen value of matrix of covariance */
                     lc1=((v1+v2)+sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     lc2=((v1+v2)-sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     /* Eigen vectors */
                     v11=(1./sqrt(1+(v1-lc1)*(v1-lc1)/cv12/cv12));
                     /*v21=sqrt(1.-v11*v11); *//* error */
                     v21=(lc1-v1)/cv12*v11;
                     v12=-v21;
                     v22=v11;
                     tnalp=v21/v11;
                     if(first1==1){
                       first1=0;
                       printf("%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tang %.3f\nOthers in log...\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     }
                     fprintf(ficlog,"%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tan %.3f\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     /*printf(fignu*/
                     /* mu1+ v11*lc1*cost + v12*lc2*sin(t) */
                     /* mu2+ v21*lc1*cost + v22*lc2*sin(t) */
                     if(first==1){
                       first=0;
                       fprintf(ficgp,"\nset parametric;unset label");
                       fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2);
                       fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
                       fprintf(fichtmcov,"\n<br>Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year<sup>-1</sup>\
    :<a href=\"%s%d%1d%1d-%1d%1d.png\">\
   %s%d%1d%1d-%1d%1d.png</A>, ",k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br><img src=\"%s%d%1d%1d-%1d%1d.png\"> ",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br> Correlation at age %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\"",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }else{
                       first=0;
                       fprintf(fichtmcov," %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }/* if first */
                   } /* age mod 5 */
                 } /* end loop age */
                 fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\";replot;",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                 first=1;
               } /*l12 */
             } /* k12 */
           } /*l1 */
         }/* k1 */
       } /* loop covariates */
     }
     free_ma3x(varpij,1,nlstate,1,nlstate+ndeath,(int) bage, (int)fage);
     free_matrix(mu,1,(nlstate+ndeath)*(nlstate+ndeath),(int) bage, (int)fage);
     free_vector(xp,1,npar);
     fclose(ficresprob);
     fclose(ficresprobcov);
     fclose(ficresprobcor);
     fflush(ficgp);
     fflush(fichtmcov);
   }
   
   
   /******************* Printing html file ***********/
   void printinghtml(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,int jmin, int jmax, double jmeanint,char rfileres[],\
                     int popforecast, int estepm ,\
                     double jprev1, double mprev1,double anprev1, \
                     double jprev2, double mprev2,double anprev2){
     int jj1, k1, i1, cpt;
   
      fprintf(fichtm,"<ul><li><a href='#firstorder'>Result files (first order: no variance)</a>\n \
      <li><a href='#secondorder'>Result files (second order (variance)</a>\n \
   </ul>");
      fprintf(fichtm,"<ul><li><h4><a name='firstorder'>Result files (first order: no variance)</a></h4>\n \
    - Observed prevalence in each state (during the period defined between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf): <a href=\"%s\">%s</a> <br>\n ",
              jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,subdirf2(fileres,"p"),subdirf2(fileres,"p"));
      fprintf(fichtm,"\
    - Estimated transition probabilities over %d (stepm) months: <a href=\"%s\">%s</a><br>\n ",
              stepm,subdirf2(fileres,"pij"),subdirf2(fileres,"pij"));
      fprintf(fichtm,"\
    - Stable prevalence in each health state: <a href=\"%s\">%s</a> <br>\n",
              subdirf2(fileres,"pl"),subdirf2(fileres,"pl"));
      fprintf(fichtm,"\
    - Life expectancies by age and initial health status (estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"e"),subdirf2(fileres,"e"));
   
   fprintf(fichtm," \n<ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        /* Pij */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i, %d (stepm) months before: %s%d1.png<br> \
   <img src=\"%s%d1.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1);     
        /* Quasi-incidences */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i %d (stepm) months\
    before but expressed in per year i.e. quasi incidences if stepm is small and probabilities too: %s%d2.png<br> \
   <img src=\"%s%d2.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1); 
          /* Stable prevalence in each health state */
          for(cpt=1; cpt<nlstate;cpt++){
            fprintf(fichtm,"<br>- Stable prevalence in each health state : p%s%d%d.png<br> \
   <img src=\"%s%d%d.png\">",subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1);
          }
        for(cpt=1; cpt<=nlstate;cpt++) {
           fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): %s%d%d.png <br> \
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1);
        }
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
   
   
    fprintf(fichtm,"\
   \n<br><li><h4> <a name='secondorder'>Result files (second order: variances)</a></h4>\n\
    - Parameter file with estimated parameters and covariance matrix: <a href=\"%s\">%s</a> <br>\n", rfileres,rfileres);
   
    fprintf(fichtm," - Variance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"prob"),subdirf2(fileres,"prob"));
    fprintf(fichtm,"\
    - Variance-covariance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcov"),subdirf2(fileres,"probcov"));
   
    fprintf(fichtm,"\
    - Correlation matrix of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcor"),subdirf2(fileres,"probcor"));
    fprintf(fichtm,"\
    - Variances and covariances of life expectancies by age and initial health status (estepm=%d months): <a href=\"%s\">%s</a><br>\n",
            estepm, subdirf2(fileres,"v"),subdirf2(fileres,"v"));
    fprintf(fichtm,"\
    - Health expectancies with their variances (no covariance): <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"t"),subdirf2(fileres,"t"));
    fprintf(fichtm,"\
    - Standard deviation of stable prevalences: <a href=\"%s\">%s</a> <br>\n",\
            subdirf2(fileres,"vpl"),subdirf2(fileres,"vpl"));
   
   /*  if(popforecast==1) fprintf(fichtm,"\n */
   /*  - Prevalences forecasting: <a href=\"f%s\">f%s</a> <br>\n */
   /*  - Population forecasting (if popforecast=1): <a href=\"pop%s\">pop%s</a> <br>\n */
   /*      <br>",fileres,fileres,fileres,fileres); */
   /*  else  */
   /*    fprintf(fichtm,"\n No population forecast: popforecast = %d (instead of 1) or stepm = %d (instead of 1) or model=%s (instead of .)<br><br></li>\n",popforecast, stepm, model); */
    fflush(fichtm);
    fprintf(fichtm," <ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        for(cpt=1; cpt<=nlstate;cpt++) {
          fprintf(fichtm,"<br>- Observed (cross-sectional) and period (incidence based) \
   prevalence (with 95%% confidence interval) in state (%d): %s%d%d.png <br>\
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"v"),cpt,jj1,subdirf2(optionfilefiname,"v"),cpt,jj1);  
        }
        fprintf(fichtm,"\n<br>- Total life expectancy by age and \
   health expectancies in states (1) and (2): %s%d.png<br>\
   <img src=\"%s%d.png\">",subdirf2(optionfilefiname,"e"),jj1,subdirf2(optionfilefiname,"e"),jj1);
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
    fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplot(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   /*   if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */
   /*     printf("Problem with file %s",optionfilegnuplot); */
   /*     fprintf(ficlog,"Problem with file %s",optionfilegnuplot); */
   /*   } */
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
     m=pow(2,cptcoveff);
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
    /* 1eme*/
     for (cpt=1; cpt<= nlstate ; cpt ++) {
      for (k1=1; k1<= m ; k1 ++) {
        fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"v"),cpt,k1);
        fprintf(ficgp,"\n#set out \"v%s%d%d.png\" \n",optionfilefiname,cpt,k1);
        fprintf(ficgp,"set xlabel \"Age\" \n\
   set ylabel \"Probability\" \n\
   set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:2 \"\%%lf",ageminpar,fage,subdirf2(fileres,"vpl"),k1-1,k1-1);
   
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }
        fprintf(ficgp,"\" t\"Stable prevalence\" w l 0,\"%s\" every :::%d::%d u 1:($2+1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1);
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        } 
        fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"%s\" every :::%d::%d u 1:($2-1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1); 
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }  
        fprintf(ficgp,"\" t\"\" w l 1,\"%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",subdirf2(fileres,"p"),k1-1,k1-1,2+4*(cpt-1));
      }
     }
     /*2 eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       fprintf(ficgp,"\nset out \"%s%d.png\" \n",subdirf2(optionfilefiname,"e"),k1);
       fprintf(ficgp,"set ylabel \"Years\" \nset ter png small\nset size 0.65,0.65\nplot [%.f:%.f] ",ageminpar,fage);
       
       for (i=1; i<= nlstate+1 ; i ++) {
         k=2*i;
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:2 \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");
         else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         fprintf(ficgp,"\" t\"\" w l 0,");
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");
         else fprintf(ficgp,"\" t\"\" w l 0,");
       }
     }
     
     /*3eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<= nlstate ; cpt ++) {
         k=2+nlstate*(2*cpt-2);
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"exp"),cpt,k1);
         fprintf(ficgp,"set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",ageminpar,fage,subdirf2(fileres,"e"),k1-1,k1-1,k,cpt);
         /*fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d-2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d+2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           
         */
         for (i=1; i< nlstate ; i ++) {
           fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+2*i,cpt,i+1);
           
         } 
       }
     }
     
     /* CV preval stable (period) */
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<=nlstate ; cpt ++) {
         k=3;
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"p"),cpt,k1);
         fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\
   set ter png small\nset size 0.65,0.65\n\
   unset log y\n\
   plot [%.f:%.f] \"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",ageminpar,agemaxpar,subdirf2(fileres,"pij"),k1,k+cpt+1,k+1);
         
         for (i=1; i< nlstate ; i ++)
           fprintf(ficgp,"+$%d",k+i+1);
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);
         
         l=3+(nlstate+ndeath)*cpt;
         fprintf(ficgp,",\"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",subdirf2(fileres,"pij"),k1,l+cpt+1,l+1);
         for (i=1; i< nlstate ; i ++) {
           l=3+(nlstate+ndeath)*cpt;
           fprintf(ficgp,"+$%d",l+i+1);
         }
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);   
       } 
     }  
     
     /* proba elementaires */
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           for(j=1; j <=ncovmodel; j++){
             fprintf(ficgp,"p%d=%f ",jk,p[jk]);
             jk++; 
             fprintf(ficgp,"\n");
           }
         }
       }
      }
   
      for(ng=1; ng<=2;ng++){ /* Number of graphics: first is probabilities second is incidence per year*/
        for(jk=1; jk <=m; jk++) {
          fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"pe"),jk,ng); 
          if (ng==2)
            fprintf(ficgp,"\nset ylabel \"Quasi-incidence per year\"\n");
          else
            fprintf(ficgp,"\nset title \"Probability\"\n");
          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65\nset log y\nplot  [%.f:%.f] ",ageminpar,agemaxpar);
          i=1;
          for(k2=1; k2<=nlstate; k2++) {
            k3=i;
            for(k=1; k<=(nlstate+ndeath); k++) {
              if (k != k2){
                if(ng==2)
                  fprintf(ficgp," %f*exp(p%d+p%d*x",YEARM/stepm,i,i+1);
                else
                  fprintf(ficgp," exp(p%d+p%d*x",i,i+1);
                ij=1;
                for(j=3; j <=ncovmodel; j++) {
                  if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                    fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                    ij++;
                  }
                  else
                    fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                }
                fprintf(ficgp,")/(1");
                
                for(k1=1; k1 <=nlstate; k1++){   
                  fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);
                  ij=1;
                  for(j=3; j <=ncovmodel; j++){
                    if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                      fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                      ij++;
                    }
                    else
                      fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                  }
                  fprintf(ficgp,")");
                }
                fprintf(ficgp,") t \"p%d%d\" ", k2,k);
                if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");
                i=i+ncovmodel;
              }
            } /* end k */
          } /* end k2 */
        } /* end jk */
      } /* end ng */
      fflush(ficgp); 
   }  /* end gnuplot */
   
   
   /*************** Moving average **************/
   int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav){
   
     int i, cpt, cptcod;
     int modcovmax =1;
     int mobilavrange, mob;
     double age;
   
     modcovmax=2*cptcoveff;/* Max number of modalities. We suppose 
                              a covariate has 2 modalities */
     if (cptcovn<1) modcovmax=1; /* At least 1 pass */
   
     if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){
       if(mobilav==1) mobilavrange=5; /* default */
       else mobilavrange=mobilav;
       for (age=bage; age<=fage; age++)
         for (i=1; i<=nlstate;i++)
           for (cptcod=1;cptcod<=modcovmax;cptcod++)
             mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod];
       /* We keep the original values on the extreme ages bage, fage and for 
          fage+1 and bage-1 we use a 3 terms moving average; for fage+2 bage+2
          we use a 5 terms etc. until the borders are no more concerned. 
       */ 
       for (mob=3;mob <=mobilavrange;mob=mob+2){
         for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){
           for (i=1; i<=nlstate;i++){
             for (cptcod=1;cptcod<=modcovmax;cptcod++){
               mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod];
                 for (cpt=1;cpt<=(mob-1)/2;cpt++){
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod];
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod];
                 }
               mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob;
             }
           }
         }/* end age */
       }/* end mob */
     }else return -1;
     return 0;
   }/* End movingaverage */
   
   
   /************** Forecasting ******************/
   prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){
     /* proj1, year, month, day of starting projection 
        agemin, agemax range of age
        dateprev1 dateprev2 range of dates during which prevalence is computed
        anproj2 year of en of projection (same day and month as proj1).
     */
     int yearp, stepsize, hstepm, nhstepm, j, k, c, cptcod, i, h, i1;
     int *popage;
     double agec; /* generic age */
     double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean;
     double *popeffectif,*popcount;
     double ***p3mat;
     double ***mobaverage;
     char fileresf[FILENAMELENGTH];
   
     agelim=AGESUP;
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
    
     strcpy(fileresf,"f"); 
     strcat(fileresf,fileres);
     if((ficresf=fopen(fileresf,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", fileresf);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", fileresf);
     }
     printf("Computing forecasting: result on file '%s' \n", fileresf);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", fileresf);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
   
     hstepm=hstepm/stepm; 
     yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp  and
                                  fractional in yp1 */
     anprojmean=yp;
     yp2=modf((yp1*12),&yp);
     mprojmean=yp;
     yp1=modf((yp2*30.5),&yp);
     jprojmean=yp;
     if(jprojmean==0) jprojmean=1;
     if(mprojmean==0) jprojmean=1;
   
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
     
     fprintf(ficresf,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); 
     
     fprintf(ficresf,"#****** Routine prevforecast **\n");
   
   /*            if (h==(int)(YEARM*yearp)){ */
     for(cptcov=1, k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficresf,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficresf," V%d=%d, hpijx=probability over h years, hp.jx is weighted by observed prev ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficresf,"******\n");
         fprintf(ficresf,"# Covariate valuofcovar yearproj age");
         for(j=1; j<=nlstate+ndeath;j++){ 
           for(i=1; i<=nlstate;i++)              
             fprintf(ficresf," p%d%d",i,j);
           fprintf(ficresf," p.%d",j);
         }
         for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { 
           fprintf(ficresf,"\n");
           fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp);   
   
           for (agec=fage; agec>=(ageminpar-1); agec--){ 
             nhstepm=(int) rint((agelim-agec)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h*hstepm/YEARM*stepm ==yearp) {
                 fprintf(ficresf,"\n");
                 for(j=1;j<=cptcoveff;j++) 
                   fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
                 fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 ppij=0.;
                 for(i=1; i<=nlstate;i++) {
                   if (mobilav==1) 
                     ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod];
                   else {
                     ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod];
                   }
                   if (h*hstepm/YEARM*stepm== yearp) {
                     fprintf(ficresf," %.3f", p3mat[i][j][h]);
                   }
                 } /* end i */
                 if (h*hstepm/YEARM*stepm==yearp) {
                   fprintf(ficresf," %.3f", ppij);
                 }
               }/* end j */
             } /* end h */
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           } /* end agec */
         } /* end yearp */
       } /* end cptcod */
     } /* end  cptcov */
          
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     fclose(ficresf);
   }
   
   /************** Forecasting *****not tested NB*************/
   populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){
     
     int cpt, stepsize, hstepm, nhstepm, j,k,c, cptcod, i,h;
     int *popage;
     double calagedatem, agelim, kk1, kk2;
     double *popeffectif,*popcount;
     double ***p3mat,***tabpop,***tabpopprev;
     double ***mobaverage;
     char filerespop[FILENAMELENGTH];
   
     tabpop= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     tabpopprev= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     agelim=AGESUP;
     calagedatem=(anpyram+mpyram/12.+jpyram/365.-dateintmean)*YEARM;
     
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     
     
     strcpy(filerespop,"pop"); 
     strcat(filerespop,fileres);
     if((ficrespop=fopen(filerespop,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", filerespop);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", filerespop);
     }
     printf("Computing forecasting: result on file '%s' \n", filerespop);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", filerespop);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     
     agelim=AGESUP;
     
     hstepm=1;
     hstepm=hstepm/stepm; 
     
     if (popforecast==1) {
       if((ficpop=fopen(popfile,"r"))==NULL) {
         printf("Problem with population file : %s\n",popfile);exit(0);
         fprintf(ficlog,"Problem with population file : %s\n",popfile);exit(0);
       } 
       popage=ivector(0,AGESUP);
       popeffectif=vector(0,AGESUP);
       popcount=vector(0,AGESUP);
       
       i=1;   
       while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF) i=i+1;
      
       imx=i;
       for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];
     }
   
     for(cptcov=1,k=0;cptcov<=i2;cptcov++){
      for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficrespop,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespop," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespop,"******\n");
         fprintf(ficrespop,"# Age");
         for(j=1; j<=nlstate+ndeath;j++) fprintf(ficrespop," P.%d",j);
         if (popforecast==1)  fprintf(ficrespop," [Population]");
         
         for (cpt=0; cpt<=0;cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficrespop,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   if (mobilav==1) 
                     kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb+1][i][cptcod];
                   else {
                     kk1=kk1+p3mat[i][j][h]*probs[(int)(agedeb+1)][i][cptcod];
                   }
                 }
                 if (h==(int)(calagedatem+12*cpt)){
                   tabpop[(int)(agedeb)][j][cptcod]=kk1;
                     /*fprintf(ficrespop," %.3f", kk1);
                       if (popforecast==1) fprintf(ficrespop," [%.f]", kk1*popeffectif[(int)agedeb+1]);*/
                 }
               }
               for(i=1; i<=nlstate;i++){
                 kk1=0.;
                   for(j=1; j<=nlstate;j++){
                     kk1= kk1+tabpop[(int)(agedeb)][j][cptcod]; 
                   }
                     tabpopprev[(int)(agedeb)][i][cptcod]=tabpop[(int)(agedeb)][i][cptcod]/kk1*popeffectif[(int)(agedeb+(calagedatem+12*cpt)*hstepm/YEARM*stepm-1)];
               }
   
               if (h==(int)(calagedatem+12*cpt)) for(j=1; j<=nlstate;j++) 
                 fprintf(ficrespop," %15.2f",tabpopprev[(int)(agedeb+1)][j][cptcod]);
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
    
     /******/
   
         for (cpt=1; cpt<=(anpyram1-anpyram);cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficresf,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   kk1=kk1+p3mat[i][j][h]*tabpopprev[(int)agedeb+1][i][cptcod];    
                 }
                 if (h==(int)(calagedatem+12*cpt)) fprintf(ficresf," %15.2f", kk1);        
               }
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
      } 
     }
    
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     if (popforecast==1) {
       free_ivector(popage,0,AGESUP);
       free_vector(popeffectif,0,AGESUP);
       free_vector(popcount,0,AGESUP);
     }
     free_ma3x(tabpop,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(tabpopprev,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficrespop);
   } /* End of popforecast */
   
   int fileappend(FILE *fichier, char *optionfich)
   {
     if((fichier=fopen(optionfich,"a"))==NULL) {
       printf("Problem with file: %s\n", optionfich);
       fprintf(ficlog,"Problem with file: %s\n", optionfich);
       return (0);
     }
     fflush(fichier);
     return (1);
   }
   
   
   /**************** function prwizard **********************/
   void prwizard(int ncovmodel, int nlstate, int ndeath,  char model[], FILE *ficparo)
   {
   
     /* Wizard to print covariance matrix template */
   
     char ca[32], cb[32], cc[32];
     int i,j, k, l, li, lj, lk, ll, jj, npar, itimes;
     int numlinepar;
   
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficparo,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         /*ca[0]= k+'a'-1;ca[1]='\0';*/
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           /*        printf(" %lf",param[i][j][k]); */
           /*        fprintf(ficparo," %lf",param[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficparo,"# Scales (for hessian or gradient estimation)\n");
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/ 
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         fprintf(ficparo,"%1d%1d",i,j);
         printf("%1d%1d",i,j);
         fflush(stdout);
         for(k=1; k<=ncovmodel;k++){
           /*      printf(" %le",delti3[i][j][k]); */
           /*      fprintf(ficparo," %le",delti3[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Covariance matrix\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
     fflush(stdout);
     fprintf(ficparo,"# Covariance matrix\n");
     /* # 121 Var(a12)\n\ */
     /* # 122 Cov(b12,a12) Var(b12)\n\ */
     /* #   ...\n\ */
     /* # 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n" */
     
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               printf("#%1d%1d%d",i,j,k);
               fprintf(ficparo,"#%1d%1d%d",i,j,k);
             }else{
               printf("%1d%1d%d",i,j,k);
               fprintf(ficparo,"%1d%1d%d",i,j,k);
               /*  printf(" %.5le",matcov[i][j]); */
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficparo," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }else{
                       if(itimes==1){
                         printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficparo," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             printf("\n");
             fprintf(ficparo,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
   } /* end of prwizard */
   /******************* Gompertz Likelihood ******************************/
   double gompertz(double x[])
   { 
     double A,B,L=0.0,sump=0.,num=0.;
     int i,n=0; /* n is the size of the sample */
     for (i=0;i<=imx-1 ; i++) {
       sump=sump+weight[i];
       /*    sump=sump+1;*/
       num=num+1;
     }
    
    
     /* for (i=0; i<=imx; i++) 
        if (wav[i]>0) printf("i=%d ageex=%lf agecens=%lf agedc=%lf cens=%d %d\n" ,i,ageexmed[i],agecens[i],agedc[i],cens[i],wav[i]);*/
   
     for (i=1;i<=imx ; i++)
       {
         if (cens[i]==1 & wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agecens[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)));
         
         if (cens[i]==0 & wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agedc[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)))
                +log(x[1]/YEARM)+x[2]*(agedc[i]-agegomp)+log(YEARM);  
         
         if (wav[i]>1 & agecens[i]>15) {
           L=L+A*weight[i];
           /*      printf("\ni=%d A=%f L=%lf x[1]=%lf x[2]=%lf ageex=%lf agecens=%lf cens=%d agedc=%lf weight=%lf\n",i,A,L,x[1],x[2],ageexmed[i]*12,agecens[i]*12,cens[i],agedc[i]*12,weight[i]);*/
         }
       }
   
    /*printf("x1=%2.9f x2=%2.9f x3=%2.9f L=%f\n",x[1],x[2],x[3],L);*/
    
     return -2*L*num/sump;
   }
   
   /******************* Printing html file ***********/
   void printinghtmlmort(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,  double p[],double **matcov,double agemortsup){
     int i,k;
   
     fprintf(fichtm,"<ul><li><h4>Result files </h4>\n Force of mortality. Parameters of the Gompertz fit (with confidence interval in brackets):<br>");
     fprintf(fichtm,"  mu(age) =%lf*exp(%lf*(age-%d)) per year<br><br>",p[1],p[2],agegomp);
     for (i=1;i<=2;i++) 
       fprintf(fichtm," p[%d] = %lf [%f ; %f]<br>\n",i,p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
     fprintf(fichtm,"<br><br><img src=\"graphmort.png\">");
     fprintf(fichtm,"</ul>");
   
   fprintf(fichtm,"<ul><li><h4>Life table</h4>\n <br>");
   
    fprintf(fichtm,"\nAge   l<inf>x</inf>     q<inf>x</inf> d(x,x+1)    L<inf>x</inf>     T<inf>x</inf>     e<infx</inf><br>");
   
    for (k=agegomp;k<(agemortsup-2);k++) 
      fprintf(fichtm,"%d %.0lf %lf %.0lf %.0lf %.0lf %lf<br>\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
    
     fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplotmort(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
   
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
     fprintf(ficgp,"set out \"graphmort.png\"\n "); 
     fprintf(ficgp,"set xlabel \"Age\"\n set ylabel \"Force of mortality (per year)\" \n "); 
     fprintf(ficgp, "set ter png small\n set log y\n"); 
     fprintf(ficgp, "set size 0.65,0.65\n");
     fprintf(ficgp,"plot [%d:100] %lf*exp(%lf*(x-%d))",agegomp,p[1],p[2],agegomp);
   
   } 
   
   
   
   
   /***********************************************/
   /**************** Main Program *****************/
   /***********************************************/
   
   int main(int argc, char *argv[])
   {
     int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav);
     int i,j, k, n=MAXN,iter,m,size=100,cptcode, cptcod;
     int linei;
     int jj, ll, li, lj, lk, imk;
     int numlinepar=0; /* Current linenumber of parameter file */
     int itimes;
     int NDIM=2;
   
     char ca[32], cb[32], cc[32];
     /*  FILE *fichtm; *//* Html File */
     /* FILE *ficgp;*/ /*Gnuplot File */
     struct stat info;
     double agedeb, agefin,hf;
     double ageminpar=1.e20,agemin=1.e20, agemaxpar=-1.e20, agemax=-1.e20;
   
     double fret;
     double **xi,tmp,delta;
   
     double dum; /* Dummy variable */
     double ***p3mat;
     double ***mobaverage;
     int *indx;
     char line[MAXLINE], linepar[MAXLINE];
     char path[MAXLINE],pathc[MAXLINE],pathcd[MAXLINE],pathtot[MAXLINE],model[MAXLINE];
     char pathr[MAXLINE], pathimach[MAXLINE]; 
     int firstobs=1, lastobs=10;
     int sdeb, sfin; /* Status at beginning and end */
     int c,  h , cpt,l;
     int ju,jl, mi;
     int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;
     int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,*tab; 
     int mobilavproj=0 , prevfcast=0 ; /* moving average of prev, If prevfcast=1 prevalence projection */
     int mobilav=0,popforecast=0;
     int hstepm, nhstepm;
     int agemortsup;
     float  sumlpop=0.;
     double jprev1=1, mprev1=1,anprev1=2000,jprev2=1, mprev2=1,anprev2=2000;
     double jpyram=1, mpyram=1,anpyram=2000,jpyram1=1, mpyram1=1,anpyram1=2000;
   
     double bage, fage, age, agelim, agebase;
     double ftolpl=FTOL;
     double **prlim;
     double *severity;
     double ***param; /* Matrix of parameters */
     double  *p;
     double **matcov; /* Matrix of covariance */
     double ***delti3; /* Scale */
     double *delti; /* Scale */
     double ***eij, ***vareij;
     double **varpl; /* Variances of prevalence limits by age */
     double *epj, vepp;
     double kk1, kk2;
     double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000;
     double **ximort;
     char *alph[]={"a","a","b","c","d","e"}, str[4];
     int *dcwave;
   
     char z[1]="c", occ;
   
     char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];
     char strstart[80], *strt, strtend[80];
     char *stratrunc;
     int lstra;
   
     long total_usecs;
    
   /*   setlocale (LC_ALL, ""); */
   /*   bindtextdomain (PACKAGE, LOCALEDIR); */
   /*   textdomain (PACKAGE); */
   /*   setlocale (LC_CTYPE, ""); */
   /*   setlocale (LC_MESSAGES, ""); */
   
     /*   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */
     (void) gettimeofday(&start_time,&tzp);
     curr_time=start_time;
     tm = *localtime(&start_time.tv_sec);
     tmg = *gmtime(&start_time.tv_sec);
     strcpy(strstart,asctime(&tm));
   
   /*  printf("Localtime (at start)=%s",strstart); */
   /*  tp.tv_sec = tp.tv_sec +86400; */
   /*  tm = *localtime(&start_time.tv_sec); */
   /*   tmg.tm_year=tmg.tm_year +dsign*dyear; */
   /*   tmg.tm_mon=tmg.tm_mon +dsign*dmonth; */
   /*   tmg.tm_hour=tmg.tm_hour + 1; */
   /*   tp.tv_sec = mktime(&tmg); */
   /*   strt=asctime(&tmg); */
   /*   printf("Time(after) =%s",strstart);  */
   /*  (void) time (&time_value);
   *  printf("time=%d,t-=%d\n",time_value,time_value-86400);
   *  tm = *localtime(&time_value);
   *  strstart=asctime(&tm);
   *  printf("tim_value=%d,asctime=%s\n",time_value,strstart); 
   */
   
     nberr=0; /* Number of errors and warnings */
     nbwarn=0;
     getcwd(pathcd, size);
   
     printf("\n%s\n%s",version,fullversion);
     if(argc <=1){
       printf("\nEnter the parameter file name: ");
       scanf("%s",pathtot);
     }
     else{
       strcpy(pathtot,argv[1]);
     }
     /*if(getcwd(pathcd, MAXLINE)!= NULL)printf ("Error pathcd\n");*/
     /*cygwin_split_path(pathtot,path,optionfile);
       printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/
     /* cutv(path,optionfile,pathtot,'\\');*/
   
     /* Split argv[0], imach program to get pathimach */
     printf("\nargv[0]=%s argv[1]=%s, \n",argv[0],argv[1]);
     split(argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
     printf("\nargv[0]=%s pathimach=%s, \noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
    /*   strcpy(pathimach,argv[0]); */
     /* Split argv[1]=pathtot, parameter file name to get path, optionfile, extension and name */
     split(pathtot,path,optionfile,optionfilext,optionfilefiname);
     printf("\npathtot=%s,\npath=%s,\noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
     chdir(path);
     strcpy(command,"mkdir ");
     strcat(command,optionfilefiname);
     if((outcmd=system(command)) != 0){
       printf("Problem creating directory or it already exists %s%s, err=%d\n",path,optionfilefiname,outcmd);
       /* fprintf(ficlog,"Problem creating directory %s%s\n",path,optionfilefiname); */
       /* fclose(ficlog); */
   /*     exit(1); */
     }
   /*   if((imk=mkdir(optionfilefiname))<0){ */
   /*     perror("mkdir"); */
   /*   } */
   
     /*-------- arguments in the command line --------*/
   
     /* Log file */
     strcat(filelog, optionfilefiname);
     strcat(filelog,".log");    /* */
     if((ficlog=fopen(filelog,"w"))==NULL)    {
       printf("Problem with logfile %s\n",filelog);
       goto end;
     }
     fprintf(ficlog,"Log filename:%s\n",filelog);
     fprintf(ficlog,"\n%s\n%s",version,fullversion);
     fprintf(ficlog,"\nEnter the parameter file name: \n");
     fprintf(ficlog,"pathimach=%s\npathtot=%s\n\
    path=%s \n\
    optionfile=%s\n\
    optionfilext=%s\n\
    optionfilefiname=%s\n",pathimach,pathtot,path,optionfile,optionfilext,optionfilefiname);
   
     printf("Local time (at start):%s",strstart);
     fprintf(ficlog,"Local time (at start): %s",strstart);
     fflush(ficlog);
   /*   (void) gettimeofday(&curr_time,&tzp); */
   /*   printf("Elapsed time %d\n", asc_diff_time(curr_time.tv_sec-start_time.tv_sec,tmpout)); */
   
     /* */
     strcpy(fileres,"r");
     strcat(fileres, optionfilefiname);
     strcat(fileres,".txt");    /* Other files have txt extension */
   
     /*---------arguments file --------*/
   
     if((ficpar=fopen(optionfile,"r"))==NULL)    {
       printf("Problem with optionfile %s\n",optionfile);
       fprintf(ficlog,"Problem with optionfile %s\n",optionfile);
       fflush(ficlog);
       goto end;
     }
   
   
   
     strcpy(filereso,"o");
     strcat(filereso,fileres);
     if((ficparo=fopen(filereso,"w"))==NULL) { /* opened on subdirectory */
       printf("Problem with Output resultfile: %s\n", filereso);
       fprintf(ficlog,"Problem with Output resultfile: %s\n", filereso);
       fflush(ficlog);
       goto end;
     }
   
     /* Reads comments: lines beginning with '#' */
     numlinepar=0;
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d model=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncovcol, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);
     numlinepar++;
     printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate,ndeath, maxwav, mle, weightopt,model);
     fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fprintf(ficlog,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fflush(ficlog);
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
      
     covar=matrix(0,NCOVMAX,1,n); 
     cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement*/
     if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;
   
     ncovmodel=2+cptcovn; /*Number of variables = cptcovn + intercept + age */
     nvar=ncovmodel-1; /* Suppressing age as a basic covariate */
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/
   
     delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     delti=delti3[1][1];
     /*delti=vector(1,npar); *//* Scale of each paramater (output from hesscov)*/
     if(mle==-1){ /* Print a wizard for help writing covariance matrix */
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       fclose (ficparo);
       fclose (ficlog);
       exit(0);
     }
     else if(mle==-3) {
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       matcov=matrix(1,npar,1,npar);
     }
     else{
       /* Read guess parameters */
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
       
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       for(i=1; i <=nlstate; i++){
         j=0;
         for(jj=1; jj <=nlstate+ndeath; jj++){
           if(jj==i) continue;
           j++;
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1 != i) && (j1 != j)){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           fprintf(ficparo,"%1d%1d",i1,j1);
           if(mle==1)
             printf("%1d%1d",i,j);
           fprintf(ficlog,"%1d%1d",i,j);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar," %lf",&param[i][j][k]);
             if(mle==1){
               printf(" %lf",param[i][j][k]);
               fprintf(ficlog," %lf",param[i][j][k]);
             }
             else
               fprintf(ficlog," %lf",param[i][j][k]);
             fprintf(ficparo," %lf",param[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           if(mle==1)
             printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficparo,"\n");
         }
       }  
       fflush(ficlog);
   
       p=param[1][1];
       
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
   
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath-1; j++){
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1-i)*(j1-j)!=0){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           printf("%1d%1d",i,j);
           fprintf(ficparo,"%1d%1d",i1,j1);
           fprintf(ficlog,"%1d%1d",i1,j1);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar,"%le",&delti3[i][j][k]);
             printf(" %le",delti3[i][j][k]);
             fprintf(ficparo," %le",delti3[i][j][k]);
             fprintf(ficlog," %le",delti3[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           printf("\n");
           fprintf(ficparo,"\n");
           fprintf(ficlog,"\n");
         }
       }
       fflush(ficlog);
   
       delti=delti3[1][1];
   
   
       /* free_ma3x(delti3,1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ /* Hasn't to to freed here otherwise delti is no more allocated */
     
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
     
       matcov=matrix(1,npar,1,npar);
       for(i=1; i <=npar; i++){
         fscanf(ficpar,"%s",&str);
         if(mle==1)
           printf("%s",str);
         fprintf(ficlog,"%s",str);
         fprintf(ficparo,"%s",str);
         for(j=1; j <=i; j++){
           fscanf(ficpar," %le",&matcov[i][j]);
           if(mle==1){
             printf(" %.5le",matcov[i][j]);
           }
           fprintf(ficlog," %.5le",matcov[i][j]);
           fprintf(ficparo," %.5le",matcov[i][j]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         if(mle==1)
           printf("\n");
         fprintf(ficlog,"\n");
         fprintf(ficparo,"\n");
       }
       for(i=1; i <=npar; i++)
         for(j=i+1;j<=npar;j++)
           matcov[i][j]=matcov[j][i];
       
       if(mle==1)
         printf("\n");
       fprintf(ficlog,"\n");
       
       fflush(ficlog);
       
       /*-------- Rewriting parameter file ----------*/
       strcpy(rfileres,"r");    /* "Rparameterfile */
       strcat(rfileres,optionfilefiname);    /* Parameter file first name*/
       strcat(rfileres,".");    /* */
       strcat(rfileres,optionfilext);    /* Other files have txt extension */
       if((ficres =fopen(rfileres,"w"))==NULL) {
         printf("Problem writing new parameter file: %s\n", fileres);goto end;
         fprintf(ficlog,"Problem writing new parameter file: %s\n", fileres);goto end;
       }
       fprintf(ficres,"#%s\n",version);
     }    /* End of mle != -3 */
   
     /*-------- data file ----------*/
     if((fic=fopen(datafile,"r"))==NULL)    {
       printf("Problem with datafile: %s\n", datafile);goto end;
       fprintf(ficlog,"Problem with datafile: %s\n", datafile);goto end;
     }
   
     n= lastobs;
     severity = vector(1,maxwav);
     outcome=imatrix(1,maxwav+1,1,n);
     num=lvector(1,n);
     moisnais=vector(1,n);
     annais=vector(1,n);
     moisdc=vector(1,n);
     andc=vector(1,n);
     agedc=vector(1,n);
     cod=ivector(1,n);
     weight=vector(1,n);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */
     mint=matrix(1,maxwav,1,n);
     anint=matrix(1,maxwav,1,n);
     s=imatrix(1,maxwav+1,1,n);
     tab=ivector(1,NCOVMAX);
     ncodemax=ivector(1,8);
   
     i=1;
     linei=0;
     while ((fgets(line, MAXLINE, fic) != NULL) ||((i >= firstobs) && (i <=lastobs)))    {
       linei=linei+1;
       printf("IIIII= %d linei=%d\n",i,linei);
       for(j=strlen(line); j>=0;j--){  /* Untabifies line */
           if(line[j] == '\t')
             line[j] = ' ';
         }
         for(j=strlen(line)-1; (line[j]==' ')||(line[j]==10);j--){;};line[j+1]=0;  /* Trims blanks at end of line */
         if(line[0]=='#'){
           fprintf(ficlog,"Comment line\n%s\n",line);
           printf("Comment line\n%s\n",line);
           continue;
         }
         for (j=maxwav;j>=1;j--){
           cutv(stra, strb,line,' '); 
           errno=0;
           lval=strtol(strb,&endptr,10); 
           /*      if (errno == ERANGE && (lval == LONG_MAX || lval == LONG_MIN))*/
           if( strb[0]=='\0' || (*endptr != '\0')){
             printf("Error reading data around '%d' at line number %d %s for individual %d\nShould be a status of wave %d. Setting maxwav=%d might be wrong.  Exiting.\n",lval, i,line,linei,j,maxwav);
             exit(1);
           }
           s[j][i]=lval;
   
           strcpy(line,stra);
           cutv(stra, strb,line,'/');
           errno=0;
           lval=strtol(strb,&endptr,10); 
           if( strb[0]=='\0' || (*endptr != '\0')){
             printf("Error reading data around '%d'.at line number %ld %s for individual %d\nShould be a year of exam at wave %d.  Exiting.\n",lval, i,line,linei,j);
             exit(1);
           }
           anint[j][i]=(double)(lval); 
   
           strcpy(line,stra);
           cutv(stra, strb,line,' ');
           errno=0;
           lval=strtol(strb,&endptr,10); 
           if( strb[0]=='\0' || (*endptr != '\0')){
             printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a month of exam at wave %d.  Exiting.\n",lval, i,line, linei,j);
             exit(1);
           }
           mint[j][i]=(double)(lval); 
           strcpy(line,stra);
         }
           
         cutv(stra, strb,line,'/'); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a year of death.  Exiting.\n",lval, i,line,linei);
           exit(1);
         }
         andc[i]=(double)(lval); 
         strcpy(line,stra);
   
         cutv(stra, strb,line,' '); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a month of death.  Exiting.\n",lval,i,line, linei);
           exit(1);
         }
         moisdc[i]=(double)(lval); 
   
         strcpy(line,stra);
         cutv(stra, strb,line,'/'); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a year of birth.  Exiting.\n",lval, i,line, linei);
           exit(1);
         }
         annais[i]=(double)(lval);
   
         strcpy(line,stra);
         cutv(stra, strb,line,' ');
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a month of birth.  Exiting.\n",lval,i,line,linei);
           exit(1);
         }
         moisnais[i]=(double)(lval); 
         strcpy(line,stra);
   
         cutv(stra, strb,line,' '); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a weight.  Exiting.\n",lval, i,line,linei);
           exit(1);
         }
         weight[i]=(double)(lval); 
         strcpy(line,stra);
   
         for (j=ncovcol;j>=1;j--){
           cutv(stra, strb,line,' '); 
           errno=0;
           lval=strtol(strb,&endptr,10); 
           if( strb[0]=='\0' || (*endptr != '\0')){
             printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a covar (meaning 0 for the reference or 1).  Exiting.\n",lval, i,line,linei);
             exit(1);
           }
           if(lval <0 || lval >1){
             printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a value of the %d covar (meaning 0 for the reference or 1. IMaCh does not build design variables, do it your self).  Exiting.\n",lval,i,line,linei,j);
             exit(1);
           }
           covar[j][i]=(double)(lval);
           strcpy(line,stra);
         } 
         lstra=strlen(stra);
   
         if(lstra > 9){ /* More than 2**32 or max of what printf can write with %ld */
           stratrunc = &(stra[lstra-9]);
           num[i]=atol(stratrunc);
         }
         else
           num[i]=atol(stra);
         printf ("num [i] %ld %d\n",i, num[i]);fflush(stdout);
         /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){
           printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/
   
         i=i+1;
     } /* End loop reading  data */
     /* printf("ii=%d", ij);
        scanf("%d",i);*/
     imx=i-1; /* Number of individuals */
   
     /* for (i=1; i<=imx; i++){
       if ((s[1][i]==3) && (s[2][i]==2)) s[2][i]=3;
       if ((s[2][i]==3) && (s[3][i]==2)) s[3][i]=3;
       if ((s[3][i]==3) && (s[4][i]==2)) s[4][i]=3;
       }*/
      /*  for (i=1; i<=imx; i++){
        if (s[4][i]==9)  s[4][i]=-1; 
        printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));}*/
     
     /* for (i=1; i<=imx; i++) */
    
      /*if ((s[3][i]==3) ||  (s[4][i]==3)) weight[i]=0.08;
        else weight[i]=1;*/
   
     /* Calculation of the number of parameters from char model */
     Tvar=ivector(1,15); /* stores the number n of the covariates in Vm+Vn at 1 and m at 2 */
     Tprod=ivector(1,15); 
     Tvaraff=ivector(1,15); 
     Tvard=imatrix(1,15,1,2);
     Tage=ivector(1,15);      
      
     if (strlen(model) >1){ /* If there is at least 1 covariate */
       j=0, j1=0, k1=1, k2=1;
       j=nbocc(model,'+'); /* j=Number of '+' */
       j1=nbocc(model,'*'); /* j1=Number of '*' */
       cptcovn=j+1; 
       cptcovprod=j1; /*Number of products */
       
       strcpy(modelsav,model); 
       if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){
         printf("Error. Non available option model=%s ",model);
         fprintf(ficlog,"Error. Non available option model=%s ",model);
         goto end;
       }
       
       /* This loop fills the array Tvar from the string 'model'.*/
   
       for(i=(j+1); i>=1;i--){
         cutv(stra,strb,modelsav,'+'); /* keeps in strb after the last + */ 
         if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav); /* and analyzes it */
         /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/
         /*scanf("%d",i);*/
         if (strchr(strb,'*')) {  /* Model includes a product */
           cutv(strd,strc,strb,'*'); /* strd*strc  Vm*Vn (if not *age)*/
           if (strcmp(strc,"age")==0) { /* Vn*age */
             cptcovprod--;
             cutv(strb,stre,strd,'V');
             Tvar[i]=atoi(stre); /* computes n in Vn and stores in Tvar*/
             cptcovage++;
               Tage[cptcovage]=i;
               /*printf("stre=%s ", stre);*/
           }
           else if (strcmp(strd,"age")==0) { /* or age*Vn */
             cptcovprod--;
             cutv(strb,stre,strc,'V');
             Tvar[i]=atoi(stre);
             cptcovage++;
             Tage[cptcovage]=i;
           }
           else {  /* Age is not in the model */
             cutv(strb,stre,strc,'V'); /* strc= Vn, stre is n*/
             Tvar[i]=ncovcol+k1;
             cutv(strb,strc,strd,'V'); /* strd was Vm, strc is m */
             Tprod[k1]=i;
             Tvard[k1][1]=atoi(strc); /* m*/
             Tvard[k1][2]=atoi(stre); /* n */
             Tvar[cptcovn+k2]=Tvard[k1][1];
             Tvar[cptcovn+k2+1]=Tvard[k1][2]; 
             for (k=1; k<=lastobs;k++) 
               covar[ncovcol+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];
             k1++;
             k2=k2+2;
           }
         }
         else { /* no more sum */
           /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/
          /*  scanf("%d",i);*/
         cutv(strd,strc,strb,'V');
         Tvar[i]=atoi(strc);
         }
         strcpy(modelsav,stra);  
         /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);
           scanf("%d",i);*/
       } /* end of loop + */
     } /* end model */
     
     /*The number n of Vn is stored in Tvar. cptcovage =number of age covariate. Tage gives the position of age. cptcovprod= number of products.
       If model=V1+V1*age then Tvar[1]=1 Tvar[2]=1 cptcovage=1 Tage[1]=2 cptcovprod=0*/
   
     /* printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);
     printf("cptcovprod=%d ", cptcovprod);
     fprintf(ficlog,"cptcovprod=%d ", cptcovprod);
   
     scanf("%d ",i);
     fclose(fic);*/
   
       /*  if(mle==1){*/
     if (weightopt != 1) { /* Maximisation without weights*/
       for(i=1;i<=n;i++) weight[i]=1.0;
     }
       /*-calculation of age at interview from date of interview and age at death -*/
     agev=matrix(1,maxwav,1,imx);
   
     for (i=1; i<=imx; i++) {
       for(m=2; (m<= maxwav); m++) {
         if (((int)mint[m][i]== 99) && (s[m][i] <= nlstate)){
           anint[m][i]=9999;
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]==9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           fprintf(ficlog,"Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]!=9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Month of death of individual %ld on line %d was unknown %2d, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,(int)moisdc[i]); 
           fprintf(ficlog,"Error! Month of death of individual %ld on line %d was unknown %f, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,moisdc[i]); 
           s[m][i]=-1; /* We prefer to skip it (and to skip it in version 0.8a1 too */
         }
       }
     }
   
     for (i=1; i<=imx; i++)  {
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);
       for(m=firstpass; (m<= lastpass); m++){
         if(s[m][i] >0 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5){
           if (s[m][i] >= nlstate+1) {
             if(agedc[i]>0)
               if((int)moisdc[i]!=99 && (int)andc[i]!=9999)
                 agev[m][i]=agedc[i];
             /*if(moisdc[i]==99 && andc[i]==9999) s[m][i]=-1;*/
               else {
                 if ((int)andc[i]!=9999){
                   nbwarn++;
                   printf("Warning negative age at death: %ld line:%d\n",num[i],i);
                   fprintf(ficlog,"Warning negative age at death: %ld line:%d\n",num[i],i);
                   agev[m][i]=-1;
                 }
               }
           }
           else if(s[m][i] !=9){ /* Standard case, age in fractional
                                    years but with the precision of a month */
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);
             if((int)mint[m][i]==99 || (int)anint[m][i]==9999)
               agev[m][i]=1;
             else if(agev[m][i] <agemin){ 
               agemin=agev[m][i];
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/
             }
             else if(agev[m][i] >agemax){
               agemax=agev[m][i];
               /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/
             }
             /*agev[m][i]=anint[m][i]-annais[i];*/
             /*     agev[m][i] = age[i]+2*m;*/
           }
           else { /* =9 */
             agev[m][i]=1;
             s[m][i]=-1;
           }
         }
         else /*= 0 Unknown */
           agev[m][i]=1;
       }
       
     }
     for (i=1; i<=imx; i++)  {
       for(m=firstpass; (m<=lastpass); m++){
         if (s[m][i] > (nlstate+ndeath)) {
           nberr++;
           printf("Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           fprintf(ficlog,"Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           goto end;
         }
       }
     }
   
     /*for (i=1; i<=imx; i++){
     for (m=firstpass; (m<lastpass); m++){
        printf("%ld %d %.lf %d %d\n", num[i],(covar[1][i]),agev[m][i],s[m][i],s[m+1][i]);
   }
   
   }*/
   
   
     printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);
     fprintf(ficlog,"Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax); 
   
     agegomp=(int)agemin;
     free_vector(severity,1,maxwav);
     free_imatrix(outcome,1,maxwav+1,1,n);
     free_vector(moisnais,1,n);
     free_vector(annais,1,n);
     /* free_matrix(mint,1,maxwav,1,n);
        free_matrix(anint,1,maxwav,1,n);*/
     free_vector(moisdc,1,n);
     free_vector(andc,1,n);
   
      
     wav=ivector(1,imx);
     dh=imatrix(1,lastpass-firstpass+1,1,imx);
     bh=imatrix(1,lastpass-firstpass+1,1,imx);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);
      
     /* Concatenates waves */
     concatwav(wav, dh, bh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);
   
     /* Routine tricode is to calculate cptcoveff (real number of unique covariates) and to associate covariable number and modality */
   
     Tcode=ivector(1,100);
     nbcode=imatrix(0,NCOVMAX,0,NCOVMAX); 
     ncodemax[1]=1;
     if (cptcovn > 0) tricode(Tvar,nbcode,imx);
         
     codtab=imatrix(1,100,1,10); /* Cross tabulation to get the order of 
                                    the estimations*/
     h=0;
     m=pow(2,cptcoveff);
    
     for(k=1;k<=cptcoveff; k++){
       for(i=1; i <=(m/pow(2,k));i++){
         for(j=1; j <= ncodemax[k]; j++){
           for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){
             h++;
             if (h>m) h=1;codtab[h][k]=j;codtab[h][Tvar[k]]=j;
             /*  printf("h=%d k=%d j=%d codtab[h][k]=%d tvar[k]=%d \n",h, k,j,codtab[h][k],Tvar[k]);*/
           } 
         }
       }
     } 
     /* printf("codtab[1][2]=%d codtab[2][2]=%d",codtab[1][2],codtab[2][2]); 
        codtab[1][2]=1;codtab[2][2]=2; */
     /* for(i=1; i <=m ;i++){ 
        for(k=1; k <=cptcovn; k++){
        printf("i=%d k=%d %d %d ",i,k,codtab[i][k], cptcoveff);
        }
        printf("\n");
        }
        scanf("%d",i);*/
       
     /*------------ gnuplot -------------*/
     strcpy(optionfilegnuplot,optionfilefiname);
     if(mle==-3)
       strcat(optionfilegnuplot,"-mort");
     strcat(optionfilegnuplot,".gp");
   
     if((ficgp=fopen(optionfilegnuplot,"w"))==NULL) {
       printf("Problem with file %s",optionfilegnuplot);
     }
     else{
       fprintf(ficgp,"\n# %s\n", version); 
       fprintf(ficgp,"# %s\n", optionfilegnuplot); 
       fprintf(ficgp,"set missing 'NaNq'\n");
     }
     /*  fclose(ficgp);*/
     /*--------- index.htm --------*/
   
     strcpy(optionfilehtm,optionfilefiname); /* Main html file */
     if(mle==-3)
       strcat(optionfilehtm,"-mort");
     strcat(optionfilehtm,".htm");
     if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtm), exit(0);
     }
   
     strcpy(optionfilehtmcov,optionfilefiname); /* Only for matrix of covariance */
     strcat(optionfilehtmcov,"-cov.htm");
     if((fichtmcov=fopen(optionfilehtmcov,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtmcov), exit(0);
     }
     else{
     fprintf(fichtmcov,"<body>\n<title>IMaCh Cov %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model);
     }
   
     fprintf(fichtm,"<body>\n<title>IMaCh %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n\
   \n\
   <hr  size=\"2\" color=\"#EC5E5E\">\
    <ul><li><h4>Parameter files</h4>\n\
    - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>\n\
    - Log file of the run: <a href=\"%s\">%s</a><br>\n\
    - Gnuplot file name: <a href=\"%s\">%s</a><br>\n\
    - Date and time at start: %s</ul>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model,\
             fileres,fileres,\
             filelog,filelog,optionfilegnuplot,optionfilegnuplot,strstart);
     fflush(fichtm);
   
     strcpy(pathr,path);
     strcat(pathr,optionfilefiname);
     chdir(optionfilefiname); /* Move to directory named optionfile */
     
     /* Calculates basic frequencies. Computes observed prevalence at single age
        and prints on file fileres'p'. */
     freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart);
   
     fprintf(fichtm,"\n");
     fprintf(fichtm,"<br>Total number of observations=%d <br>\n\
   Youngest age at first (selected) pass %.2f, oldest age %.2f<br>\n\
   Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>\n",\
             imx,agemin,agemax,jmin,jmax,jmean);
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */
       
      
     /* For Powell, parameters are in a vector p[] starting at p[1]
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */
   
     globpr=0; /* To get the number ipmx of contributions and the sum of weights*/
     if (mle==-3){
       ximort=matrix(1,NDIM,1,NDIM);
       cens=ivector(1,n);
       ageexmed=vector(1,n);
       agecens=vector(1,n);
       dcwave=ivector(1,n);
    
       for (i=1; i<=imx; i++){
         dcwave[i]=-1;
         for (j=1; j<=lastpass; j++)
           if (s[j][i]>nlstate) {
             dcwave[i]=j;
             /*    printf("i=%d j=%d s=%d dcwave=%d\n",i,j, s[j][i],dcwave[i]);*/
             break;
           }
       }
   
       for (i=1; i<=imx; i++) {
         if (wav[i]>0){
           ageexmed[i]=agev[mw[1][i]][i];
           j=wav[i];agecens[i]=1.; 
           if (ageexmed[i]>1 & wav[i]>0) agecens[i]=agev[mw[j][i]][i];
           cens[i]=1;
           
           if (ageexmed[i]<1) cens[i]=-1;
           if (agedc[i]< AGESUP & agedc[i]>1 & dcwave[i]>firstpass & dcwave[i]<=lastpass) cens[i]=0 ;
         }
         else cens[i]=-1;
       }
       
       for (i=1;i<=NDIM;i++) {
         for (j=1;j<=NDIM;j++)
           ximort[i][j]=(i == j ? 1.0 : 0.0);
       }
   
       p[1]=0.1; p[2]=0.1;
       /*printf("%lf %lf", p[1], p[2]);*/
       
       
     printf("Powell\n");  fprintf(ficlog,"Powell\n");
     strcpy(filerespow,"pow-mort"); 
     strcat(filerespow,fileres);
     if((ficrespow=fopen(filerespow,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", filerespow);
       fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
     }
     fprintf(ficrespow,"# Powell\n# iter -2*LL");
     /*  for (i=1;i<=nlstate;i++)
       for(j=1;j<=nlstate+ndeath;j++)
         if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
     */
     fprintf(ficrespow,"\n");
   
       powell(p,ximort,NDIM,ftol,&iter,&fret,gompertz);
       fclose(ficrespow);
       
       hesscov(matcov, p, NDIM,delti, 1e-4, gompertz); 
   
       for(i=1; i <=NDIM; i++)
         for(j=i+1;j<=NDIM;j++)
           matcov[i][j]=matcov[j][i];
       
       printf("\nCovariance matrix\n ");
       for(i=1; i <=NDIM; i++) {
         for(j=1;j<=NDIM;j++){ 
           printf("%f ",matcov[i][j]);
         }
         printf("\n ");
       }
       
       printf("iter=%d MLE=%f Eq=%lf*exp(%lf*(age-%d))\n",iter,-gompertz(p),p[1],p[2],agegomp);
       for (i=1;i<=NDIM;i++) 
         printf("%f [%f ; %f]\n",p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
   
   lsurv=vector(1,AGESUP);
       lpop=vector(1,AGESUP);
       tpop=vector(1,AGESUP);
       lsurv[agegomp]=100000;
      
        for (k=agegomp;k<=AGESUP;k++) {
         agemortsup=k;
         if (p[1]*exp(p[2]*(k-agegomp))>1) break;
       }
      
         for (k=agegomp;k<agemortsup;k++)
         lsurv[k+1]=lsurv[k]-lsurv[k]*(p[1]*exp(p[2]*(k-agegomp)));
   
       for (k=agegomp;k<agemortsup;k++){
         lpop[k]=(lsurv[k]+lsurv[k+1])/2.;
         sumlpop=sumlpop+lpop[k];
       }
   
    tpop[agegomp]=sumlpop;
       for (k=agegomp;k<(agemortsup-3);k++){
         /*  tpop[k+1]=2;*/
         tpop[k+1]=tpop[k]-lpop[k];
          }
      
      
          printf("\nAge   lx     qx    dx    Lx     Tx     e(x)\n");
       for (k=agegomp;k<(agemortsup-2);k++) 
         printf("%d %.0lf %lf %.0lf %.0lf %.0lf %lf\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
   
       replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
       printinggnuplotmort(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtmlmort(fileres,title,datafile, firstpass, lastpass, \
                        stepm, weightopt,\
                        model,imx,p,matcov,agemortsup);
   
       free_vector(lsurv,1,AGESUP);
       free_vector(lpop,1,AGESUP);
       free_vector(tpop,1,AGESUP);
     } /* Endof if mle==-3 */
   
     else{ /* For mle >=1 */
     
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("First Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       globpr=1; /* to print the contributions */
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("Second Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       if(mle>=1){ /* Could be 1 or 2 */
         mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);
       }
       
       /*--------- results files --------------*/
       fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle= 0 weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate, ndeath, maxwav, weightopt,model);
       
       
       fprintf(ficres,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       fprintf(ficlog,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(k=1; k <=(nlstate+ndeath); k++){
           if (k != i) {
             printf("%d%d ",i,k);
             fprintf(ficlog,"%d%d ",i,k);
             fprintf(ficres,"%1d%1d ",i,k);
             for(j=1; j <=ncovmodel; j++){
               printf("%f ",p[jk]);
               fprintf(ficlog,"%f ",p[jk]);
               fprintf(ficres,"%f ",p[jk]);
               jk++; 
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       if(mle!=0){
         /* Computing hessian and covariance matrix */
         ftolhess=ftol; /* Usually correct */
         hesscov(matcov, p, npar, delti, ftolhess, func);
       }
       fprintf(ficres,"# Scales (for hessian or gradient estimation)\n");
       printf("# Scales (for hessian or gradient estimation)\n");
       fprintf(ficlog,"# Scales (for hessian or gradient estimation)\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if (j!=i) {
             fprintf(ficres,"%1d%1d",i,j);
             printf("%1d%1d",i,j);
             fprintf(ficlog,"%1d%1d",i,j);
             for(k=1; k<=ncovmodel;k++){
               printf(" %.5e",delti[jk]);
               fprintf(ficlog," %.5e",delti[jk]);
               fprintf(ficres," %.5e",delti[jk]);
               jk++;
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       
       fprintf(ficres,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       if(mle>=1)
         printf("# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       fprintf(ficlog,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       /* # 121 Var(a12)\n\ */
       /* # 122 Cov(b12,a12) Var(b12)\n\ */
       /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
       /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
       /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
       /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
       /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
       /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
       
       
       /* Just to have a covariance matrix which will be more understandable
          even is we still don't want to manage dictionary of variables
       */
       for(itimes=1;itimes<=2;itimes++){
         jj=0;
         for(i=1; i <=nlstate; i++){
           for(j=1; j <=nlstate+ndeath; j++){
             if(j==i) continue;
             for(k=1; k<=ncovmodel;k++){
               jj++;
               ca[0]= k+'a'-1;ca[1]='\0';
               if(itimes==1){
                 if(mle>=1)
                   printf("#%1d%1d%d",i,j,k);
                 fprintf(ficlog,"#%1d%1d%d",i,j,k);
                 fprintf(ficres,"#%1d%1d%d",i,j,k);
               }else{
                 if(mle>=1)
                   printf("%1d%1d%d",i,j,k);
                 fprintf(ficlog,"%1d%1d%d",i,j,k);
                 fprintf(ficres,"%1d%1d%d",i,j,k);
               }
               ll=0;
               for(li=1;li <=nlstate; li++){
                 for(lj=1;lj <=nlstate+ndeath; lj++){
                   if(lj==li) continue;
                   for(lk=1;lk<=ncovmodel;lk++){
                     ll++;
                     if(ll<=jj){
                       cb[0]= lk +'a'-1;cb[1]='\0';
                       if(ll<jj){
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficlog," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficres," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }else{
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficlog," Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficres," Var(%s%1d%1d)",ca,i,j);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }
                     }
                   } /* end lk */
                 } /* end lj */
               } /* end li */
               if(mle>=1)
                 printf("\n");
               fprintf(ficlog,"\n");
               fprintf(ficres,"\n");
               numlinepar++;
             } /* end k*/
           } /*end j */
         } /* end i */
       } /* end itimes */
       
       fflush(ficlog);
       fflush(ficres);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       estepm=0;
       fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf estepm=%d\n",&ageminpar,&agemaxpar, &bage, &fage, &estepm);
       if (estepm==0 || estepm < stepm) estepm=stepm;
       if (fage <= 2) {
         bage = ageminpar;
         fage = agemaxpar;
       }
       
       fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");
       fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"begin-prev-date=%lf/%lf/%lf end-prev-date=%lf/%lf/%lf mov_average=%d\n",&jprev1, &mprev1,&anprev1,&jprev2, &mprev2,&anprev2,&mobilav);
       fprintf(ficparo,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficres,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       printf("begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficlog,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       
       dateprev1=anprev1+(mprev1-1)/12.+(jprev1-1)/365.;
       dateprev2=anprev2+(mprev2-1)/12.+(jprev2-1)/365.;
       
       fscanf(ficpar,"pop_based=%d\n",&popbased);
       fprintf(ficparo,"pop_based=%d\n",popbased);   
       fprintf(ficres,"pop_based=%d\n",popbased);   
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"prevforecast=%d starting-proj-date=%lf/%lf/%lf final-proj-date=%lf/%lf/%lf mobil_average=%d\n",&prevfcast,&jproj1,&mproj1,&anproj1,&jproj2,&mproj2,&anproj2,&mobilavproj);
       fprintf(ficparo,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       printf("prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficlog,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficres,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       /* day and month of proj2 are not used but only year anproj2.*/
       
       
       
       /*  freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);*/
       /*,dateprev1,dateprev2,jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
       
       replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
       printinggnuplot(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtml(fileres,title,datafile, firstpass, lastpass, stepm, weightopt,\
                    model,imx,jmin,jmax,jmean,rfileres,popforecast,estepm,\
                    jprev1,mprev1,anprev1,jprev2,mprev2,anprev2);
         
      /*------------ free_vector  -------------*/
      /*  chdir(path); */
    
       free_ivector(wav,1,imx);
       free_imatrix(dh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(bh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
       free_lvector(num,1,n);
       free_vector(agedc,1,n);
       /*free_matrix(covar,0,NCOVMAX,1,n);*/
       /*free_matrix(covar,1,NCOVMAX,1,n);*/
       fclose(ficparo);
       fclose(ficres);
   
   
       /*--------------- Prevalence limit  (stable prevalence) --------------*/
     
       strcpy(filerespl,"pl");
       strcat(filerespl,fileres);
       if((ficrespl=fopen(filerespl,"w"))==NULL) {
         printf("Problem with stable prevalence resultfile: %s\n", filerespl);goto end;
         fprintf(ficlog,"Problem with stable prevalence resultfile: %s\n", filerespl);goto end;
       }
       printf("Computing stable prevalence: result on file '%s' \n", filerespl);
       fprintf(ficlog,"Computing stable prevalence: result on file '%s' \n", filerespl);
       fprintf(ficrespl, "#Local time at start: %s", strstart);
       fprintf(ficrespl,"#Stable prevalence \n");
       fprintf(ficrespl,"#Age ");
       for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);
       fprintf(ficrespl,"\n");
     
       prlim=matrix(1,nlstate,1,nlstate);
   
       agebase=ageminpar;
       agelim=agemaxpar;
       ftolpl=1.e-10;
       i1=cptcoveff;
       if (cptcovn < 1){i1=1;}
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/
           fprintf(ficrespl,"\n#******");
           printf("\n#******");
           fprintf(ficlog,"\n#******");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             printf(" V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficlog," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficrespl,"******\n");
           printf("******\n");
           fprintf(ficlog,"******\n");
           
           for (age=agebase; age<=agelim; age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             fprintf(ficrespl,"%.0f ",age );
             for(j=1;j<=cptcoveff;j++)
               fprintf(ficrespl,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             for(i=1; i<=nlstate;i++)
               fprintf(ficrespl," %.5f", prlim[i][i]);
             fprintf(ficrespl,"\n");
           }
         }
       }
       fclose(ficrespl);
   
       /*------------- h Pij x at various ages ------------*/
     
       strcpy(filerespij,"pij");  strcat(filerespij,fileres);
       if((ficrespij=fopen(filerespij,"w"))==NULL) {
         printf("Problem with Pij resultfile: %s\n", filerespij);goto end;
         fprintf(ficlog,"Problem with Pij resultfile: %s\n", filerespij);goto end;
       }
       printf("Computing pij: result on file '%s' \n", filerespij);
       fprintf(ficlog,"Computing pij: result on file '%s' \n", filerespij);
     
       stepsize=(int) (stepm+YEARM-1)/YEARM;
       /*if (stepm<=24) stepsize=2;*/
   
       agelim=AGESUP;
       hstepm=stepsize*YEARM; /* Every year of age */
       hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */ 
   
       /* hstepm=1;   aff par mois*/
       fprintf(ficrespij, "#Local time at start: %s", strstart);
       fprintf(ficrespij,"#****** h Pij x Probability to be in state j at age x+h being in i at x ");
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficrespij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrespij,"******\n");
           
           for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
             nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
   
             /*      nhstepm=nhstepm*YEARM; aff par mois*/
   
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             fprintf(ficrespij,"# Cov Agex agex+h hpijx with i,j=");
             for(i=1; i<=nlstate;i++)
               for(j=1; j<=nlstate+ndeath;j++)
                 fprintf(ficrespij," %1d-%1d",i,j);
             fprintf(ficrespij,"\n");
             for (h=0; h<=nhstepm; h++){
               fprintf(ficrespij,"%d %3.f %3.f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );
               for(i=1; i<=nlstate;i++)
                 for(j=1; j<=nlstate+ndeath;j++)
                   fprintf(ficrespij," %.5f", p3mat[i][j][h]);
               fprintf(ficrespij,"\n");
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             fprintf(ficrespij,"\n");
           }
         }
       }
   
       varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax,strstart);
   
       fclose(ficrespij);
   
       probs= ma3x(1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
       for(i=1;i<=AGESUP;i++)
         for(j=1;j<=NCOVMAX;j++)
           for(k=1;k<=NCOVMAX;k++)
             probs[i][j][k]=0.;
   
       /*---------- Forecasting ------------------*/
       /*if((stepm == 1) && (strcmp(model,".")==0)){*/
       if(prevfcast==1){
         /*    if(stepm ==1){*/
         prevforecast(fileres, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff);
         /* (popforecast==1) populforecast(fileres, anpyram,mpyram,jpyram, agemin,agemax, dateprev1, dateprev2,mobilav, agedeb, fage, popforecast, popfile, anpyram1,p, i1);*/
         /*      }  */
         /*      else{ */
         /*        erreur=108; */
         /*        printf("Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*        fprintf(ficlog,"Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*      } */
       }
     
   
       /*---------- Health expectancies and variances ------------*/
   
       strcpy(filerest,"t");
       strcat(filerest,fileres);
       if((ficrest=fopen(filerest,"w"))==NULL) {
         printf("Problem with total LE resultfile: %s\n", filerest);goto end;
         fprintf(ficlog,"Problem with total LE resultfile: %s\n", filerest);goto end;
       }
       printf("Computing Total LEs with variances: file '%s' \n", filerest); 
       fprintf(ficlog,"Computing Total LEs with variances: file '%s' \n", filerest); 
   
   
       strcpy(filerese,"e");
       strcat(filerese,fileres);
       if((ficreseij=fopen(filerese,"w"))==NULL) {
         printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
         fprintf(ficlog,"Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
       }
       printf("Computing Health Expectancies: result on file '%s' \n", filerese);
       fprintf(ficlog,"Computing Health Expectancies: result on file '%s' \n", filerese);
   
       strcpy(fileresv,"v");
       strcat(fileresv,fileres);
       if((ficresvij=fopen(fileresv,"w"))==NULL) {
         printf("Problem with variance resultfile: %s\n", fileresv);exit(0);
         fprintf(ficlog,"Problem with variance resultfile: %s\n", fileresv);exit(0);
       }
       printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
       fprintf(ficlog,"Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
   
       /* Computes prevalence between agemin (i.e minimal age computed) and no more ageminpar */
       prevalence(probs, agemin, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
       /*  printf("ageminpar=%f, agemax=%f, s[lastpass][imx]=%d, agev[lastpass][imx]=%f, nlstate=%d, imx=%d,  mint[lastpass][imx]=%f, anint[lastpass][imx]=%f,dateprev1=%f, dateprev2=%f, firstpass=%d, lastpass=%d\n",\
           ageminpar, agemax, s[lastpass][imx], agev[lastpass][imx], nlstate, imx, mint[lastpass][imx],anint[lastpass][imx], dateprev1, dateprev2, firstpass, lastpass);
       */
   
       if (mobilav!=0) {
         mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
         if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
           fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
           printf(" Error in movingaverage mobilav=%d\n",mobilav);
         }
       }
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1; 
           fprintf(ficrest,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrest,"******\n");
   
           fprintf(ficreseij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficreseij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficreseij,"******\n");
   
           fprintf(ficresvij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvij,"******\n");
   
           eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, delti, matcov, strstart);  
    
           vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,0, mobilav, strstart);
           if(popbased==1){
             varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,popbased,mobilav, strstart);
           }
   
           fprintf(ficrest, "#Local time at start: %s", strstart);
           fprintf(ficrest,"#Total LEs with variances: e.. (std) ");
           for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);
           fprintf(ficrest,"\n");
   
           epj=vector(1,nlstate+1);
           for(age=bage; age <=fage ;age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             if (popbased==1) {
               if(mobilav ==0){
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=probs[(int)age][i][k];
               }else{ /* mobilav */ 
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=mobaverage[(int)age][i][k];
               }
             }
           
             fprintf(ficrest," %4.0f",age);
             for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){
               for(i=1, epj[j]=0.;i <=nlstate;i++) {
                 epj[j] += prlim[i][i]*eij[i][j][(int)age];
                 /*  printf("%lf %lf ", prlim[i][i] ,eij[i][j][(int)age]);*/
               }
               epj[nlstate+1] +=epj[j];
             }
   
             for(i=1, vepp=0.;i <=nlstate;i++)
               for(j=1;j <=nlstate;j++)
                 vepp += vareij[i][j][(int)age];
             fprintf(ficrest," %7.3f (%7.3f)", epj[nlstate+1],sqrt(vepp));
             for(j=1;j <=nlstate;j++){
               fprintf(ficrest," %7.3f (%7.3f)", epj[j],sqrt(vareij[j][j][(int)age]));
             }
             fprintf(ficrest,"\n");
           }
           free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_vector(epj,1,nlstate+1);
         }
       }
       free_vector(weight,1,n);
       free_imatrix(Tvard,1,15,1,2);
       free_imatrix(s,1,maxwav+1,1,n);
       free_matrix(anint,1,maxwav,1,n); 
       free_matrix(mint,1,maxwav,1,n);
       free_ivector(cod,1,n);
       free_ivector(tab,1,NCOVMAX);
       fclose(ficreseij);
       fclose(ficresvij);
       fclose(ficrest);
       fclose(ficpar);
     
       /*------- Variance of stable prevalence------*/   
   
       strcpy(fileresvpl,"vpl");
       strcat(fileresvpl,fileres);
       if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {
         printf("Problem with variance of stable prevalence  resultfile: %s\n", fileresvpl);
         exit(0);
       }
       printf("Computing Variance-covariance of stable prevalence: file '%s' \n", fileresvpl);
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficresvpl,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvpl,"******\n");
         
           varpl=matrix(1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k,strstart);
           free_matrix(varpl,1,nlstate,(int) bage, (int)fage);
         }
       }
   
       fclose(ficresvpl);
   
       /*---------- End : free ----------------*/
       if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       free_ma3x(probs,1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     }  /* mle==-3 arrives here for freeing */
       free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);
     
       free_matrix(covar,0,NCOVMAX,1,n);
       free_matrix(matcov,1,npar,1,npar);
       /*free_vector(delti,1,npar);*/
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       free_matrix(agev,1,maxwav,1,imx);
       free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);
   
       free_ivector(ncodemax,1,8);
       free_ivector(Tvar,1,15);
       free_ivector(Tprod,1,15);
       free_ivector(Tvaraff,1,15);
       free_ivector(Tage,1,15);
       free_ivector(Tcode,1,100);
   
   
     fflush(fichtm);
     fflush(ficgp);
     
   
     if((nberr >0) || (nbwarn>0)){
       printf("End of Imach with %d errors and/or %d warnings\n",nberr,nbwarn);
       fprintf(ficlog,"End of Imach with %d errors and/or warnings %d\n",nberr,nbwarn);
     }else{
       printf("End of Imach\n");
       fprintf(ficlog,"End of Imach\n");
     }
     printf("See log file on %s\n",filelog);
     /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */
     (void) gettimeofday(&end_time,&tzp);
     tm = *localtime(&end_time.tv_sec);
     tmg = *gmtime(&end_time.tv_sec);
     strcpy(strtend,asctime(&tm));
     printf("Local time at start %s\nLocal time at end   %s",strstart, strtend); 
     fprintf(ficlog,"Local time at start %s\nLocal time at end   %s\n",strstart, strtend); 
     printf("Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
   
     printf("Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     fprintf(ficlog,"Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
     fprintf(ficlog,"Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     /*  printf("Total time was %d uSec.\n", total_usecs);*/
   /*   if(fileappend(fichtm,optionfilehtm)){ */
     fprintf(fichtm,"<br>Local time at start %s<br>Local time at end   %s<br>",strstart, strtend);
     fclose(fichtm);
     fclose(fichtmcov);
     fclose(ficgp);
     fclose(ficlog);
     /*------ End -----------*/
   
     chdir(path);
   #ifndef UNIX
     /*  strcpy(plotcmd,"\""); */
   #endif
     strcpy(plotcmd,pathimach);
     /*strcat(plotcmd,CHARSEPARATOR);*/
     strcat(plotcmd,GNUPLOTPROGRAM);
   #ifndef UNIX
     strcat(plotcmd,".exe");
     /*  strcat(plotcmd,"\"");*/
   #endif
     if(stat(plotcmd,&info)){
       printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
     }
   
   #ifndef UNIX
     strcpy(plotcmd,"\"");
   #endif
     strcat(plotcmd,pathimach);
     strcat(plotcmd,GNUPLOTPROGRAM);
   #ifndef UNIX
     strcat(plotcmd,".exe");
     strcat(plotcmd,"\"");
   #endif
     strcat(plotcmd," ");
     strcat(plotcmd,optionfilegnuplot);
     printf("Starting graphs with: %s",plotcmd);fflush(stdout);
   
     if((outcmd=system(plotcmd)) != 0){
       printf("\n Problem with gnuplot\n");
     }
     printf(" Wait...");
     while (z[0] != 'q') {
       /* chdir(path); */
       printf("\nType e to edit output files, g to graph again and q for exiting: ");
       scanf("%s",z);
   /*     if (z[0] == 'c') system("./imach"); */
       if (z[0] == 'e') {
         printf("Starting browser with: %s",optionfilehtm);fflush(stdout);
         system(optionfilehtm);
       }
       else if (z[0] == 'g') system(plotcmd);
       else if (z[0] == 'q') exit(0);
     }
     end:
     while (z[0] != 'q') {
       printf("\nType  q for exiting: ");
       scanf("%s",z);
     }
   }
   
   
   

Removed from v.1.2  
changed lines
  Added in v.1.109


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