Diff for /imach/src/imach.c between versions 1.5 and 1.95

version 1.5, 2001/05/02 17:42:45 version 1.95, 2003/07/08 07:54:34
Line 1 Line 1
      /* $Id$
 /*********************** Imach **************************************            $State$
   This program computes Healthy Life Expectancies from cross-longitudinal    $Log$
   data. Cross-longitudinal consist in a first survey ("cross") where    Revision 1.95  2003/07/08 07:54:34  brouard
   individuals from different ages are interviewed on their health status    * imach.c (Repository):
   or degree of  disability. At least a second wave of interviews    (Repository): Using imachwizard code to output a more meaningful covariance
   ("longitudinal") should  measure each new individual health status.    matrix (cov(a12,c31) instead of numbers.
   Health expectancies are computed from the transistions observed between  
   waves and are computed for each degree of severity of disability (number    Revision 1.94  2003/06/27 13:00:02  brouard
   of life states). More degrees you consider, more time is necessary to    Just cleaning
   reach the Maximum Likelihood of the parameters involved in the model.  
   The simplest model is the multinomial logistic model where pij is    Revision 1.93  2003/06/25 16:33:55  brouard
   the probabibility to be observed in state j at the second wave conditional    (Module): On windows (cygwin) function asctime_r doesn't
   to be observed in state i at the first wave. Therefore the model is:    exist so I changed back to asctime which exists.
   log(pij/pii)= aij + bij*age+ cij*sex + etc , where 'age' is age and 'sex'    (Module): Version 0.96b
   is a covariate. If you want to have a more complex model than "constant and  
   age", you should modify the program where the markup    Revision 1.92  2003/06/25 16:30:45  brouard
     *Covariates have to be included here again* invites you to do it.    (Module): On windows (cygwin) function asctime_r doesn't
   More covariates you add, less is the speed of the convergence.    exist so I changed back to asctime which exists.
   
   The advantage that this computer programme claims, comes from that if the    Revision 1.91  2003/06/25 15:30:29  brouard
   delay between waves is not identical for each individual, or if some    * imach.c (Repository): Duplicated warning errors corrected.
   individual missed an interview, the information is not rounded or lost, but    (Repository): Elapsed time after each iteration is now output. It
   taken into account using an interpolation or extrapolation.    helps to forecast when convergence will be reached. Elapsed time
   hPijx is the probability to be    is stamped in powell.  We created a new html file for the graphs
   observed in state i at age x+h conditional to the observed state i at age    concerning matrix of covariance. It has extension -cov.htm.
   x. The delay 'h' can be split into an exact number (nh*stepm) of  
   unobserved intermediate  states. This elementary transition (by month or    Revision 1.90  2003/06/24 12:34:15  brouard
   quarter trimester, semester or year) is model as a multinomial logistic.    (Module): Some bugs corrected for windows. Also, when
   The hPx matrix is simply the matrix product of nh*stepm elementary matrices    mle=-1 a template is output in file "or"mypar.txt with the design
   and the contribution of each individual to the likelihood is simply hPijx.    of the covariance matrix to be input.
   
   Also this programme outputs the covariance matrix of the parameters but also    Revision 1.89  2003/06/24 12:30:52  brouard
   of the life expectancies. It also computes the prevalence limits.    (Module): Some bugs corrected for windows. Also, when
      mle=-1 a template is output in file "or"mypar.txt with the design
   Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).    of the covariance matrix to be input.
            Institut national d'études démographiques, Paris.  
   This software have been partly granted by Euro-REVES, a concerted action    Revision 1.88  2003/06/23 17:54:56  brouard
   from the European Union.    * imach.c (Repository): Create a sub-directory where all the secondary files are. Only imach, htm, gp and r(imach) are on the main directory. Correct time and other things.
   It is copyrighted identically to a GNU software product, ie programme and  
   software can be distributed freely for non commercial use. Latest version    Revision 1.87  2003/06/18 12:26:01  brouard
   can be accessed at http://euroreves.ined.fr/imach .    Version 0.96
   **********************************************************************/  
      Revision 1.86  2003/06/17 20:04:08  brouard
 #include <math.h>    (Module): Change position of html and gnuplot routines and added
 #include <stdio.h>    routine fileappend.
 #include <stdlib.h>  
 #include <unistd.h>    Revision 1.85  2003/06/17 13:12:43  brouard
     * imach.c (Repository): Check when date of death was earlier that
 #define MAXLINE 256    current date of interview. It may happen when the death was just
 #define FILENAMELENGTH 80    prior to the death. In this case, dh was negative and likelihood
 /*#define DEBUG*/    was wrong (infinity). We still send an "Error" but patch by
 #define windows    assuming that the date of death was just one stepm after the
 #define GLOCK_ERROR_NOPATH              -1      /* empty path */    interview.
 #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */    (Repository): Because some people have very long ID (first column)
     we changed int to long in num[] and we added a new lvector for
     memory allocation. But we also truncated to 8 characters (left
     truncation)
 #define MAXPARM 30 /* Maximum number of parameters for the optimization */    (Repository): No more line truncation errors.
 #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */  
     Revision 1.84  2003/06/13 21:44:43  brouard
 #define NINTERVMAX 8    * imach.c (Repository): Replace "freqsummary" at a correct
 #define NLSTATEMAX 8 /* Maximum number of live states (for func) */    place. It differs from routine "prevalence" which may be called
 #define NDEATHMAX 8 /* Maximum number of dead states (for func) */    many times. Probs is memory consuming and must be used with
 #define NCOVMAX 8 /* Maximum number of covariates */    parcimony.
 #define MAXN 20000    Version 0.95a3 (should output exactly the same maximization than 0.8a2)
 #define YEARM 12. /* Number of months per year */  
 #define AGESUP 130    Revision 1.83  2003/06/10 13:39:11  lievre
 #define AGEBASE 40    *** empty log message ***
   
     Revision 1.82  2003/06/05 15:57:20  brouard
 int nvar;    Add log in  imach.c and  fullversion number is now printed.
 static int cptcov;  
 int cptcovn;  */
 int npar=NPARMAX;  /*
 int nlstate=2; /* Number of live states */     Interpolated Markov Chain
 int ndeath=1; /* Number of dead states */  
 int ncovmodel, ncov;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */    Short summary of the programme:
     
 int *wav; /* Number of waves for this individuual 0 is possible */    This program computes Healthy Life Expectancies from
 int maxwav; /* Maxim number of waves */    cross-longitudinal data. Cross-longitudinal data consist in: -1- a
 int mle, weightopt;    first survey ("cross") where individuals from different ages are
 int **mw; /* mw[mi][i] is number of the mi wave for this individual */    interviewed on their health status or degree of disability (in the
 int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */    case of a health survey which is our main interest) -2- at least a
 double **oldm, **newm, **savm; /* Working pointers to matrices */    second wave of interviews ("longitudinal") which measure each change
 double **oldms, **newms, **savms; /* Fixed working pointers to matrices */    (if any) in individual health status.  Health expectancies are
 FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest;    computed from the time spent in each health state according to a
 FILE *ficgp, *fichtm;    model. More health states you consider, more time is necessary to reach the
 FILE *ficreseij;    Maximum Likelihood of the parameters involved in the model.  The
   char filerese[FILENAMELENGTH];    simplest model is the multinomial logistic model where pij is the
  FILE  *ficresvij;    probability to be observed in state j at the second wave
   char fileresv[FILENAMELENGTH];    conditional to be observed in state i at the first wave. Therefore
  FILE  *ficresvpl;    the model is: log(pij/pii)= aij + bij*age+ cij*sex + etc , where
   char fileresvpl[FILENAMELENGTH];    'age' is age and 'sex' is a covariate. If you want to have a more
     complex model than "constant and age", you should modify the program
     where the markup *Covariates have to be included here again* invites
     you to do it.  More covariates you add, slower the
     convergence.
 #define NR_END 1  
 #define FREE_ARG char*    The advantage of this computer programme, compared to a simple
 #define FTOL 1.0e-10    multinomial logistic model, is clear when the delay between waves is not
     identical for each individual. Also, if a individual missed an
 #define NRANSI    intermediate interview, the information is lost, but taken into
 #define ITMAX 200    account using an interpolation or extrapolation.  
   
 #define TOL 2.0e-4    hPijx is the probability to be observed in state i at age x+h
     conditional to the observed state i at age x. The delay 'h' can be
 #define CGOLD 0.3819660    split into an exact number (nh*stepm) of unobserved intermediate
 #define ZEPS 1.0e-10    states. This elementary transition (by month, quarter,
 #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d);    semester or year) is modelled as a multinomial logistic.  The hPx
     matrix is simply the matrix product of nh*stepm elementary matrices
 #define GOLD 1.618034    and the contribution of each individual to the likelihood is simply
 #define GLIMIT 100.0    hPijx.
 #define TINY 1.0e-20  
     Also this programme outputs the covariance matrix of the parameters but also
 static double maxarg1,maxarg2;    of the life expectancies. It also computes the stable prevalence. 
 #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))    
 #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))    Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).
               Institut national d'études démographiques, Paris.
 #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))    This software have been partly granted by Euro-REVES, a concerted action
 #define rint(a) floor(a+0.5)    from the European Union.
     It is copyrighted identically to a GNU software product, ie programme and
 static double sqrarg;    software can be distributed freely for non commercial use. Latest version
 #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)    can be accessed at http://euroreves.ined.fr/imach .
 #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;}  
     Help to debug: LD_PRELOAD=/usr/local/lib/libnjamd.so ./imach foo.imach
 int imx;    or better on gdb : set env LD_PRELOAD=/usr/local/lib/libnjamd.so
 int stepm;    
 /* Stepm, step in month: minimum step interpolation*/    **********************************************************************/
   /*
 int m,nb;    main
 int *num, firstpass=0, lastpass=4,*cod, *ncodemax;    read parameterfile
 double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;    read datafile
 double **pmmij;    concatwav
     freqsummary
 double *weight;    if (mle >= 1)
 int **s; /* Status */      mlikeli
 double *agedc, **covar, idx;    print results files
 int **nbcode, *Tcode, *Tvar, **codtab;    if mle==1 
        computes hessian
 double ftol=FTOL; /* Tolerance for computing Max Likelihood */    read end of parameter file: agemin, agemax, bage, fage, estepm
 double ftolhess; /* Tolerance for computing hessian */        begin-prev-date,...
     open gnuplot file
     open html file
 static  int split( char *path, char *dirc, char *name )    stable prevalence
 {     for age prevalim()
    char *s;                             /* pointer */    h Pij x
    int  l1, l2;                         /* length counters */    variance of p varprob
     forecasting if prevfcast==1 prevforecast call prevalence()
    l1 = strlen( path );                 /* length of path */    health expectancies
    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );    Variance-covariance of DFLE
    s = strrchr( path, '\\' );           /* find last / */    prevalence()
    if ( s == NULL ) {                   /* no directory, so use current */     movingaverage()
 #if     defined(__bsd__)                /* get current working directory */    varevsij() 
       extern char       *getwd( );    if popbased==1 varevsij(,popbased)
     total life expectancies
       if ( getwd( dirc ) == NULL ) {    Variance of stable prevalence
 #else   end
       extern char       *getcwd( );  */
   
       if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {  
 #endif  
          return( GLOCK_ERROR_GETCWD );   
       }  #include <math.h>
       strcpy( name, path );             /* we've got it */  #include <stdio.h>
    } else {                             /* strip direcotry from path */  #include <stdlib.h>
       s++;                              /* after this, the filename */  #include <unistd.h>
       l2 = strlen( s );                 /* length of filename */  
       if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );  #include <sys/time.h>
       strcpy( name, s );                /* save file name */  #include <time.h>
       strncpy( dirc, path, l1 - l2 );   /* now the directory */  #include "timeval.h"
       dirc[l1-l2] = 0;                  /* add zero */  
    }  /* #include <libintl.h> */
    l1 = strlen( dirc );                 /* length of directory */  /* #define _(String) gettext (String) */
    if ( dirc[l1-1] != '\\' ) { dirc[l1] = '\\'; dirc[l1+1] = 0; }  
    return( 0 );                         /* we're done */  #define MAXLINE 256
 }  #define GNUPLOTPROGRAM "gnuplot"
   /*#define GNUPLOTPROGRAM "..\\gp37mgw\\wgnuplot"*/
   #define FILENAMELENGTH 132
 /******************************************/  /*#define DEBUG*/
   /*#define windows*/
 void replace(char *s, char*t)  #define GLOCK_ERROR_NOPATH              -1      /* empty path */
 {  #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */
   int i;  
   int lg=20;  #define MAXPARM 30 /* Maximum number of parameters for the optimization */
   i=0;  #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */
   lg=strlen(t);  
   for(i=0; i<= lg; i++) {  #define NINTERVMAX 8
     (s[i] = t[i]);  #define NLSTATEMAX 8 /* Maximum number of live states (for func) */
     if (t[i]== '\\') s[i]='/';  #define NDEATHMAX 8 /* Maximum number of dead states (for func) */
   }  #define NCOVMAX 8 /* Maximum number of covariates */
 }  #define MAXN 20000
   #define YEARM 12. /* Number of months per year */
 int nbocc(char *s, char occ)  #define AGESUP 130
 {  #define AGEBASE 40
   int i,j=0;  #ifdef unix
   int lg=20;  #define DIRSEPARATOR '/'
   i=0;  #define ODIRSEPARATOR '\\'
   lg=strlen(s);  #else
   for(i=0; i<= lg; i++) {  #define DIRSEPARATOR '\\'
   if  (s[i] == occ ) j++;  #define ODIRSEPARATOR '/'
   }  #endif
   return j;  
 }  /* $Id$ */
   /* $State$ */
 void cutv(char *u,char *v, char*t, char occ)  
 {  char version[]="Imach version 0.96b, June 2003, INED-EUROREVES ";
   int i,lg,j,p;  char fullversion[]="$Revision$ $Date$"; 
   i=0;  int erreur, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings  */
   for(j=0; j<=strlen(t)-1; j++) {  int nvar;
     if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;  int cptcovn=0, cptcovage=0, cptcoveff=0,cptcov;
   }  int npar=NPARMAX;
   int nlstate=2; /* Number of live states */
   lg=strlen(t);  int ndeath=1; /* Number of dead states */
   for(j=0; j<p; j++) {  int ncovmodel, ncovcol;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */
     (u[j] = t[j]);  int popbased=0;
     u[p]='\0';  
   }  int *wav; /* Number of waves for this individuual 0 is possible */
   int maxwav; /* Maxim number of waves */
    for(j=0; j<= lg; j++) {  int jmin, jmax; /* min, max spacing between 2 waves */
     if (j>=(p+1))(v[j-p-1] = t[j]);  int gipmx, gsw; /* Global variables on the number of contributions 
   }                     to the likelihood and the sum of weights (done by funcone)*/
 }  int mle, weightopt;
   int **mw; /* mw[mi][i] is number of the mi wave for this individual */
 /********************** nrerror ********************/  int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */
   int **bh; /* bh[mi][i] is the bias (+ or -) for this individual if the delay between
 void nrerror(char error_text[])             * wave mi and wave mi+1 is not an exact multiple of stepm. */
 {  double jmean; /* Mean space between 2 waves */
   fprintf(stderr,"ERREUR ...\n");  double **oldm, **newm, **savm; /* Working pointers to matrices */
   fprintf(stderr,"%s\n",error_text);  double **oldms, **newms, **savms; /* Fixed working pointers to matrices */
   exit(1);  FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest,*ficresf,*ficrespop;
 }  FILE *ficlog, *ficrespow;
 /*********************** vector *******************/  int globpr; /* Global variable for printing or not */
 double *vector(int nl, int nh)  double fretone; /* Only one call to likelihood */
 {  long ipmx; /* Number of contributions */
   double *v;  double sw; /* Sum of weights */
   v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));  char fileresilk[FILENAMELENGTH]; /* File of individual contributions to the likelihood */
   if (!v) nrerror("allocation failure in vector");  FILE *ficresilk;
   return v-nl+NR_END;  FILE *ficgp,*ficresprob,*ficpop, *ficresprobcov, *ficresprobcor;
 }  FILE *ficresprobmorprev;
   FILE *fichtm, *fichtmcov; /* Html File */
 /************************ free vector ******************/  FILE *ficreseij;
 void free_vector(double*v, int nl, int nh)  char filerese[FILENAMELENGTH];
 {  FILE  *ficresvij;
   free((FREE_ARG)(v+nl-NR_END));  char fileresv[FILENAMELENGTH];
 }  FILE  *ficresvpl;
   char fileresvpl[FILENAMELENGTH];
 /************************ivector *******************************/  char title[MAXLINE];
 int *ivector(long nl,long nh)  char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];
 {  char optionfilext[10], optionfilefiname[FILENAMELENGTH], plotcmd[FILENAMELENGTH];
   int *v;  char tmpout[FILENAMELENGTH]; 
   v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));  char command[FILENAMELENGTH];
   if (!v) nrerror("allocation failure in ivector");  int  outcmd=0;
   return v-nl+NR_END;  
 }  char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], rfileres[FILENAMELENGTH];
   
 /******************free ivector **************************/  char filelog[FILENAMELENGTH]; /* Log file */
 void free_ivector(int *v, long nl, long nh)  char filerest[FILENAMELENGTH];
 {  char fileregp[FILENAMELENGTH];
   free((FREE_ARG)(v+nl-NR_END));  char popfile[FILENAMELENGTH];
 }  
   char optionfilegnuplot[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH], optionfilehtmcov[FILENAMELENGTH] ;
 /******************* imatrix *******************************/  
 int **imatrix(long nrl, long nrh, long ncl, long nch)  struct timeval start_time, end_time, curr_time, last_time, forecast_time;
      /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */  struct timezone tzp;
 {  extern int gettimeofday();
   long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;  struct tm tmg, tm, tmf, *gmtime(), *localtime();
   int **m;  long time_value;
    extern long time();
   /* allocate pointers to rows */  char strcurr[80], strfor[80];
   m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*)));  
   if (!m) nrerror("allocation failure 1 in matrix()");  #define NR_END 1
   m += NR_END;  #define FREE_ARG char*
   m -= nrl;  #define FTOL 1.0e-10
    
    #define NRANSI 
   /* allocate rows and set pointers to them */  #define ITMAX 200 
   m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int)));  
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  #define TOL 2.0e-4 
   m[nrl] += NR_END;  
   m[nrl] -= ncl;  #define CGOLD 0.3819660 
    #define ZEPS 1.0e-10 
   for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;  #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d); 
    
   /* return pointer to array of pointers to rows */  #define GOLD 1.618034 
   return m;  #define GLIMIT 100.0 
 }  #define TINY 1.0e-20 
   
 /****************** free_imatrix *************************/  static double maxarg1,maxarg2;
 void free_imatrix(m,nrl,nrh,ncl,nch)  #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))
       int **m;  #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))
       long nch,ncl,nrh,nrl;    
      /* free an int matrix allocated by imatrix() */  #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))
 {  #define rint(a) floor(a+0.5)
   free((FREE_ARG) (m[nrl]+ncl-NR_END));  
   free((FREE_ARG) (m+nrl-NR_END));  static double sqrarg;
 }  #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)
   #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;} 
 /******************* matrix *******************************/  
 double **matrix(long nrl, long nrh, long ncl, long nch)  int imx; 
 {  int stepm;
   long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;  /* Stepm, step in month: minimum step interpolation*/
   double **m;  
   int estepm;
   m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  /* Estepm, step in month to interpolate survival function in order to approximate Life Expectancy*/
   if (!m) nrerror("allocation failure 1 in matrix()");  
   m += NR_END;  int m,nb;
   m -= nrl;  long *num;
   int firstpass=0, lastpass=4,*cod, *ncodemax, *Tage;
   m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  double **pmmij, ***probs;
   m[nrl] += NR_END;  double dateintmean=0;
   m[nrl] -= ncl;  
   double *weight;
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  int **s; /* Status */
   return m;  double *agedc, **covar, idx;
 }  int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;
   
 /*************************free matrix ************************/  double ftol=FTOL; /* Tolerance for computing Max Likelihood */
 void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)  double ftolhess; /* Tolerance for computing hessian */
 {  
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  /**************** split *************************/
   free((FREE_ARG)(m+nrl-NR_END));  static  int split( char *path, char *dirc, char *name, char *ext, char *finame )
 }  {
     char  *ss;                            /* pointer */
 /******************* ma3x *******************************/    int   l1, l2;                         /* length counters */
 double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)  
 {    l1 = strlen(path );                   /* length of path */
   long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );
   double ***m;    ss= strrchr( path, DIRSEPARATOR );            /* find last / */
     if ( ss == NULL ) {                   /* no directory, so use current */
   m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));      /*if(strrchr(path, ODIRSEPARATOR )==NULL)
   if (!m) nrerror("allocation failure 1 in matrix()");        printf("Warning you should use %s as a separator\n",DIRSEPARATOR);*/
   m += NR_END;      /* get current working directory */
   m -= nrl;      /*    extern  char* getcwd ( char *buf , int len);*/
       if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {
   m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));        return( GLOCK_ERROR_GETCWD );
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");      }
   m[nrl] += NR_END;      strcpy( name, path );               /* we've got it */
   m[nrl] -= ncl;    } else {                              /* strip direcotry from path */
       ss++;                               /* after this, the filename */
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;      l2 = strlen( ss );                  /* length of filename */
       if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );
   m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));      strcpy( name, ss );         /* save file name */
   if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");      strncpy( dirc, path, l1 - l2 );     /* now the directory */
   m[nrl][ncl] += NR_END;      dirc[l1-l2] = 0;                    /* add zero */
   m[nrl][ncl] -= nll;    }
   for (j=ncl+1; j<=nch; j++)    l1 = strlen( dirc );                  /* length of directory */
     m[nrl][j]=m[nrl][j-1]+nlay;    /*#ifdef windows
      if ( dirc[l1-1] != '\\' ) { dirc[l1] = '\\'; dirc[l1+1] = 0; }
   for (i=nrl+1; i<=nrh; i++) {  #else
     m[i][ncl]=m[i-1l][ncl]+ncol*nlay;    if ( dirc[l1-1] != '/' ) { dirc[l1] = '/'; dirc[l1+1] = 0; }
     for (j=ncl+1; j<=nch; j++)  #endif
       m[i][j]=m[i][j-1]+nlay;    */
   }    ss = strrchr( name, '.' );            /* find last / */
   return m;    ss++;
 }    strcpy(ext,ss);                       /* save extension */
     l1= strlen( name);
 /*************************free ma3x ************************/    l2= strlen(ss)+1;
 void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)    strncpy( finame, name, l1-l2);
 {    finame[l1-l2]= 0;
   free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));    return( 0 );                          /* we're done */
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  }
   free((FREE_ARG)(m+nrl-NR_END));  
 }  
   /******************************************/
 /***************** f1dim *************************/  
 extern int ncom;  void replace_back_to_slash(char *s, char*t)
 extern double *pcom,*xicom;  {
 extern double (*nrfunc)(double []);    int i;
      int lg=0;
 double f1dim(double x)    i=0;
 {    lg=strlen(t);
   int j;    for(i=0; i<= lg; i++) {
   double f;      (s[i] = t[i]);
   double *xt;      if (t[i]== '\\') s[i]='/';
      }
   xt=vector(1,ncom);  }
   for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j];  
   f=(*nrfunc)(xt);  int nbocc(char *s, char occ)
   free_vector(xt,1,ncom);  {
   return f;    int i,j=0;
 }    int lg=20;
     i=0;
 /*****************brent *************************/    lg=strlen(s);
 double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin)    for(i=0; i<= lg; i++) {
 {    if  (s[i] == occ ) j++;
   int iter;    }
   double a,b,d,etemp;    return j;
   double fu,fv,fw,fx;  }
   double ftemp;  
   double p,q,r,tol1,tol2,u,v,w,x,xm;  void cutv(char *u,char *v, char*t, char occ)
   double e=0.0;  {
      /* cuts string t into u and v where u is ended by char occ excluding it
   a=(ax < cx ? ax : cx);       and v is after occ excluding it too : ex cutv(u,v,"abcdef2ghi2j",2)
   b=(ax > cx ? ax : cx);       gives u="abcedf" and v="ghi2j" */
   x=w=v=bx;    int i,lg,j,p=0;
   fw=fv=fx=(*f)(x);    i=0;
   for (iter=1;iter<=ITMAX;iter++) {    for(j=0; j<=strlen(t)-1; j++) {
     xm=0.5*(a+b);      if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;
     tol2=2.0*(tol1=tol*fabs(x)+ZEPS);    }
     /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/  
     printf(".");fflush(stdout);    lg=strlen(t);
 #ifdef DEBUG    for(j=0; j<p; j++) {
     printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);      (u[j] = t[j]);
     /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */    }
 #endif       u[p]='\0';
     if (fabs(x-xm) <= (tol2-0.5*(b-a))){  
       *xmin=x;     for(j=0; j<= lg; j++) {
       return fx;      if (j>=(p+1))(v[j-p-1] = t[j]);
     }    }
     ftemp=fu;  }
     if (fabs(e) > tol1) {  
       r=(x-w)*(fx-fv);  /********************** nrerror ********************/
       q=(x-v)*(fx-fw);  
       p=(x-v)*q-(x-w)*r;  void nrerror(char error_text[])
       q=2.0*(q-r);  {
       if (q > 0.0) p = -p;    fprintf(stderr,"ERREUR ...\n");
       q=fabs(q);    fprintf(stderr,"%s\n",error_text);
       etemp=e;    exit(EXIT_FAILURE);
       e=d;  }
       if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x))  /*********************** vector *******************/
         d=CGOLD*(e=(x >= xm ? a-x : b-x));  double *vector(int nl, int nh)
       else {  {
         d=p/q;    double *v;
         u=x+d;    v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));
         if (u-a < tol2 || b-u < tol2)    if (!v) nrerror("allocation failure in vector");
           d=SIGN(tol1,xm-x);    return v-nl+NR_END;
       }  }
     } else {  
       d=CGOLD*(e=(x >= xm ? a-x : b-x));  /************************ free vector ******************/
     }  void free_vector(double*v, int nl, int nh)
     u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d));  {
     fu=(*f)(u);    free((FREE_ARG)(v+nl-NR_END));
     if (fu <= fx) {  }
       if (u >= x) a=x; else b=x;  
       SHFT(v,w,x,u)  /************************ivector *******************************/
         SHFT(fv,fw,fx,fu)  int *ivector(long nl,long nh)
         } else {  {
           if (u < x) a=u; else b=u;    int *v;
           if (fu <= fw || w == x) {    v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));
             v=w;    if (!v) nrerror("allocation failure in ivector");
             w=u;    return v-nl+NR_END;
             fv=fw;  }
             fw=fu;  
           } else if (fu <= fv || v == x || v == w) {  /******************free ivector **************************/
             v=u;  void free_ivector(int *v, long nl, long nh)
             fv=fu;  {
           }    free((FREE_ARG)(v+nl-NR_END));
         }  }
   }  
   nrerror("Too many iterations in brent");  /************************lvector *******************************/
   *xmin=x;  long *lvector(long nl,long nh)
   return fx;  {
 }    long *v;
     v=(long *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(long)));
 /****************** mnbrak ***********************/    if (!v) nrerror("allocation failure in ivector");
     return v-nl+NR_END;
 void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc,  }
             double (*func)(double))  
 {  /******************free lvector **************************/
   double ulim,u,r,q, dum;  void free_lvector(long *v, long nl, long nh)
   double fu;  {
      free((FREE_ARG)(v+nl-NR_END));
   *fa=(*func)(*ax);  }
   *fb=(*func)(*bx);  
   if (*fb > *fa) {  /******************* imatrix *******************************/
     SHFT(dum,*ax,*bx,dum)  int **imatrix(long nrl, long nrh, long ncl, long nch) 
       SHFT(dum,*fb,*fa,dum)       /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */ 
       }  { 
   *cx=(*bx)+GOLD*(*bx-*ax);    long i, nrow=nrh-nrl+1,ncol=nch-ncl+1; 
   *fc=(*func)(*cx);    int **m; 
   while (*fb > *fc) {    
     r=(*bx-*ax)*(*fb-*fc);    /* allocate pointers to rows */ 
     q=(*bx-*cx)*(*fb-*fa);    m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*))); 
     u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/    if (!m) nrerror("allocation failure 1 in matrix()"); 
       (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r));    m += NR_END; 
     ulim=(*bx)+GLIMIT*(*cx-*bx);    m -= nrl; 
     if ((*bx-u)*(u-*cx) > 0.0) {    
       fu=(*func)(u);    
     } else if ((*cx-u)*(u-ulim) > 0.0) {    /* allocate rows and set pointers to them */ 
       fu=(*func)(u);    m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int))); 
       if (fu < *fc) {    if (!m[nrl]) nrerror("allocation failure 2 in matrix()"); 
         SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx))    m[nrl] += NR_END; 
           SHFT(*fb,*fc,fu,(*func)(u))    m[nrl] -= ncl; 
           }    
     } else if ((u-ulim)*(ulim-*cx) >= 0.0) {    for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol; 
       u=ulim;    
       fu=(*func)(u);    /* return pointer to array of pointers to rows */ 
     } else {    return m; 
       u=(*cx)+GOLD*(*cx-*bx);  } 
       fu=(*func)(u);  
     }  /****************** free_imatrix *************************/
     SHFT(*ax,*bx,*cx,u)  void free_imatrix(m,nrl,nrh,ncl,nch)
       SHFT(*fa,*fb,*fc,fu)        int **m;
       }        long nch,ncl,nrh,nrl; 
 }       /* free an int matrix allocated by imatrix() */ 
   { 
 /*************** linmin ************************/    free((FREE_ARG) (m[nrl]+ncl-NR_END)); 
     free((FREE_ARG) (m+nrl-NR_END)); 
 int ncom;  } 
 double *pcom,*xicom;  
 double (*nrfunc)(double []);  /******************* matrix *******************************/
    double **matrix(long nrl, long nrh, long ncl, long nch)
 void linmin(double p[], double xi[], int n, double *fret,double (*func)(double []))  {
 {    long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;
   double brent(double ax, double bx, double cx,    double **m;
                double (*f)(double), double tol, double *xmin);  
   double f1dim(double x);    m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb,    if (!m) nrerror("allocation failure 1 in matrix()");
               double *fc, double (*func)(double));    m += NR_END;
   int j;    m -= nrl;
   double xx,xmin,bx,ax;  
   double fx,fb,fa;    m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
      if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
   ncom=n;    m[nrl] += NR_END;
   pcom=vector(1,n);    m[nrl] -= ncl;
   xicom=vector(1,n);  
   nrfunc=func;    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
   for (j=1;j<=n;j++) {    return m;
     pcom[j]=p[j];    /* print *(*(m+1)+70) or print m[1][70]; print m+1 or print &(m[1]) 
     xicom[j]=xi[j];     */
   }  }
   ax=0.0;  
   xx=1.0;  /*************************free matrix ************************/
   mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim);  void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)
   *fret=brent(ax,xx,bx,f1dim,TOL,&xmin);  {
 #ifdef DEBUG    free((FREE_ARG)(m[nrl]+ncl-NR_END));
   printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);    free((FREE_ARG)(m+nrl-NR_END));
 #endif  }
   for (j=1;j<=n;j++) {  
     xi[j] *= xmin;  /******************* ma3x *******************************/
     p[j] += xi[j];  double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)
   }  {
   free_vector(xicom,1,n);    long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;
   free_vector(pcom,1,n);    double ***m;
 }  
     m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
 /*************** powell ************************/    if (!m) nrerror("allocation failure 1 in matrix()");
 void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret,    m += NR_END;
             double (*func)(double []))    m -= nrl;
 {  
   void linmin(double p[], double xi[], int n, double *fret,    m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
               double (*func)(double []));    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
   int i,ibig,j;    m[nrl] += NR_END;
   double del,t,*pt,*ptt,*xit;    m[nrl] -= ncl;
   double fp,fptt;  
   double *xits;    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
   pt=vector(1,n);  
   ptt=vector(1,n);    m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));
   xit=vector(1,n);    if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");
   xits=vector(1,n);    m[nrl][ncl] += NR_END;
   *fret=(*func)(p);    m[nrl][ncl] -= nll;
   for (j=1;j<=n;j++) pt[j]=p[j];    for (j=ncl+1; j<=nch; j++) 
   for (*iter=1;;++(*iter)) {      m[nrl][j]=m[nrl][j-1]+nlay;
     fp=(*fret);    
     ibig=0;    for (i=nrl+1; i<=nrh; i++) {
     del=0.0;      m[i][ncl]=m[i-1l][ncl]+ncol*nlay;
     printf("\nPowell iter=%d -2*LL=%.12f",*iter,*fret);      for (j=ncl+1; j<=nch; j++) 
     for (i=1;i<=n;i++)        m[i][j]=m[i][j-1]+nlay;
       printf(" %d %.12f",i, p[i]);    }
     printf("\n");    return m; 
     for (i=1;i<=n;i++) {    /*  gdb: p *(m+1) <=> p m[1] and p (m+1) <=> p (m+1) <=> p &(m[1])
       for (j=1;j<=n;j++) xit[j]=xi[j][i];             &(m[i][j][k]) <=> *((*(m+i) + j)+k)
       fptt=(*fret);    */
 #ifdef DEBUG  }
       printf("fret=%lf \n",*fret);  
 #endif  /*************************free ma3x ************************/
       printf("%d",i);fflush(stdout);  void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)
       linmin(p,xit,n,fret,func);  {
       if (fabs(fptt-(*fret)) > del) {    free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));
         del=fabs(fptt-(*fret));    free((FREE_ARG)(m[nrl]+ncl-NR_END));
         ibig=i;    free((FREE_ARG)(m+nrl-NR_END));
       }  }
 #ifdef DEBUG  
       printf("%d %.12e",i,(*fret));  /*************** function subdirf ***********/
       for (j=1;j<=n;j++) {  char *subdirf(char fileres[])
         xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);  {
         printf(" x(%d)=%.12e",j,xit[j]);    /* Caution optionfilefiname is hidden */
       }    strcpy(tmpout,optionfilefiname);
       for(j=1;j<=n;j++)    strcat(tmpout,"/"); /* Add to the right */
         printf(" p=%.12e",p[j]);    strcat(tmpout,fileres);
       printf("\n");    return tmpout;
 #endif  }
     }  
     if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {  /*************** function subdirf2 ***********/
 #ifdef DEBUG  char *subdirf2(char fileres[], char *preop)
       int k[2],l;  {
       k[0]=1;    
       k[1]=-1;    /* Caution optionfilefiname is hidden */
       printf("Max: %.12e",(*func)(p));    strcpy(tmpout,optionfilefiname);
       for (j=1;j<=n;j++)    strcat(tmpout,"/");
         printf(" %.12e",p[j]);    strcat(tmpout,preop);
       printf("\n");    strcat(tmpout,fileres);
       for(l=0;l<=1;l++) {    return tmpout;
         for (j=1;j<=n;j++) {  }
           ptt[j]=p[j]+(p[j]-pt[j])*k[l];  
           printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);  /*************** function subdirf3 ***********/
         }  char *subdirf3(char fileres[], char *preop, char *preop2)
         printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));  {
       }    
 #endif    /* Caution optionfilefiname is hidden */
     strcpy(tmpout,optionfilefiname);
     strcat(tmpout,"/");
       free_vector(xit,1,n);    strcat(tmpout,preop);
       free_vector(xits,1,n);    strcat(tmpout,preop2);
       free_vector(ptt,1,n);    strcat(tmpout,fileres);
       free_vector(pt,1,n);    return tmpout;
       return;  }
     }  
     if (*iter == ITMAX) nrerror("powell exceeding maximum iterations.");  /***************** f1dim *************************/
     for (j=1;j<=n;j++) {  extern int ncom; 
       ptt[j]=2.0*p[j]-pt[j];  extern double *pcom,*xicom;
       xit[j]=p[j]-pt[j];  extern double (*nrfunc)(double []); 
       pt[j]=p[j];   
     }  double f1dim(double x) 
     fptt=(*func)(ptt);  { 
     if (fptt < fp) {    int j; 
       t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt);    double f;
       if (t < 0.0) {    double *xt; 
         linmin(p,xit,n,fret,func);   
         for (j=1;j<=n;j++) {    xt=vector(1,ncom); 
           xi[j][ibig]=xi[j][n];    for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j]; 
           xi[j][n]=xit[j];    f=(*nrfunc)(xt); 
         }    free_vector(xt,1,ncom); 
 #ifdef DEBUG    return f; 
         printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);  } 
         for(j=1;j<=n;j++)  
           printf(" %.12e",xit[j]);  /*****************brent *************************/
         printf("\n");  double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin) 
 #endif  { 
       }    int iter; 
     }    double a,b,d,etemp;
   }    double fu,fv,fw,fx;
 }    double ftemp;
     double p,q,r,tol1,tol2,u,v,w,x,xm; 
 /**** Prevalence limit ****************/    double e=0.0; 
    
 double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)    a=(ax < cx ? ax : cx); 
 {    b=(ax > cx ? ax : cx); 
   /* Computes the prevalence limit in each live state at age x by left multiplying the unit    x=w=v=bx; 
      matrix by transitions matrix until convergence is reached */    fw=fv=fx=(*f)(x); 
     for (iter=1;iter<=ITMAX;iter++) { 
   int i, ii,j,k;      xm=0.5*(a+b); 
   double min, max, maxmin, maxmax,sumnew=0.;      tol2=2.0*(tol1=tol*fabs(x)+ZEPS); 
   double **matprod2();      /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/
   double **out, cov[NCOVMAX], **pmij();      printf(".");fflush(stdout);
   double **newm;      fprintf(ficlog,".");fflush(ficlog);
   double agefin, delaymax=50 ; /* Max number of years to converge */  #ifdef DEBUG
       printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
   for (ii=1;ii<=nlstate+ndeath;ii++)      fprintf(ficlog,"br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
     for (j=1;j<=nlstate+ndeath;j++){      /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */
       oldm[ii][j]=(ii==j ? 1.0 : 0.0);  #endif
     }      if (fabs(x-xm) <= (tol2-0.5*(b-a))){ 
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */        *xmin=x; 
   for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){        return fx; 
     newm=savm;      } 
     /* Covariates have to be included here again */      ftemp=fu;
     cov[1]=1.;      if (fabs(e) > tol1) { 
     cov[2]=agefin;        r=(x-w)*(fx-fv); 
     if (cptcovn>0){        q=(x-v)*(fx-fw); 
       for (k=1; k<=cptcovn;k++) {cov[2+k]=nbcode[Tvar[k]][codtab[ij][k]];/*printf("Tcode[ij]=%d nbcode=%d\n",Tcode[ij],nbcode[k][Tcode[ij]]);*/}        p=(x-v)*q-(x-w)*r; 
     }        q=2.0*(q-r); 
     out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);        if (q > 0.0) p = -p; 
         q=fabs(q); 
     savm=oldm;        etemp=e; 
     oldm=newm;        e=d; 
     maxmax=0.;        if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x)) 
     for(j=1;j<=nlstate;j++){          d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
       min=1.;        else { 
       max=0.;          d=p/q; 
       for(i=1; i<=nlstate; i++) {          u=x+d; 
         sumnew=0;          if (u-a < tol2 || b-u < tol2) 
         for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];            d=SIGN(tol1,xm-x); 
         prlim[i][j]= newm[i][j]/(1-sumnew);        } 
         max=FMAX(max,prlim[i][j]);      } else { 
         min=FMIN(min,prlim[i][j]);        d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
       }      } 
       maxmin=max-min;      u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d)); 
       maxmax=FMAX(maxmax,maxmin);      fu=(*f)(u); 
     }      if (fu <= fx) { 
     if(maxmax < ftolpl){        if (u >= x) a=x; else b=x; 
       return prlim;        SHFT(v,w,x,u) 
     }          SHFT(fv,fw,fx,fu) 
   }          } else { 
 }            if (u < x) a=u; else b=u; 
             if (fu <= fw || w == x) { 
 /*************** transition probabilities **********/              v=w; 
               w=u; 
 double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )              fv=fw; 
 {              fw=fu; 
   double s1, s2;            } else if (fu <= fv || v == x || v == w) { 
   /*double t34;*/              v=u; 
   int i,j,j1, nc, ii, jj;              fv=fu; 
             } 
     for(i=1; i<= nlstate; i++){          } 
     for(j=1; j<i;j++){    } 
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){    nrerror("Too many iterations in brent"); 
         /*s2 += param[i][j][nc]*cov[nc];*/    *xmin=x; 
         s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    return fx; 
         /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/  } 
       }  
       ps[i][j]=s2;  /****************** mnbrak ***********************/
       /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/  
     }  void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc, 
     for(j=i+1; j<=nlstate+ndeath;j++){              double (*func)(double)) 
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){  { 
         s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    double ulim,u,r,q, dum;
         /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/    double fu; 
       }   
       ps[i][j]=s2;    *fa=(*func)(*ax); 
     }    *fb=(*func)(*bx); 
   }    if (*fb > *fa) { 
   for(i=1; i<= nlstate; i++){      SHFT(dum,*ax,*bx,dum) 
      s1=0;        SHFT(dum,*fb,*fa,dum) 
     for(j=1; j<i; j++)        } 
       s1+=exp(ps[i][j]);    *cx=(*bx)+GOLD*(*bx-*ax); 
     for(j=i+1; j<=nlstate+ndeath; j++)    *fc=(*func)(*cx); 
       s1+=exp(ps[i][j]);    while (*fb > *fc) { 
     ps[i][i]=1./(s1+1.);      r=(*bx-*ax)*(*fb-*fc); 
     for(j=1; j<i; j++)      q=(*bx-*cx)*(*fb-*fa); 
       ps[i][j]= exp(ps[i][j])*ps[i][i];      u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/ 
     for(j=i+1; j<=nlstate+ndeath; j++)        (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r)); 
       ps[i][j]= exp(ps[i][j])*ps[i][i];      ulim=(*bx)+GLIMIT*(*cx-*bx); 
     /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */      if ((*bx-u)*(u-*cx) > 0.0) { 
   } /* end i */        fu=(*func)(u); 
       } else if ((*cx-u)*(u-ulim) > 0.0) { 
   for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){        fu=(*func)(u); 
     for(jj=1; jj<= nlstate+ndeath; jj++){        if (fu < *fc) { 
       ps[ii][jj]=0;          SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx)) 
       ps[ii][ii]=1;            SHFT(*fb,*fc,fu,(*func)(u)) 
     }            } 
   }      } else if ((u-ulim)*(ulim-*cx) >= 0.0) { 
         u=ulim; 
   /*   for(ii=1; ii<= nlstate+ndeath; ii++){        fu=(*func)(u); 
     for(jj=1; jj<= nlstate+ndeath; jj++){      } else { 
      printf("%lf ",ps[ii][jj]);        u=(*cx)+GOLD*(*cx-*bx); 
    }        fu=(*func)(u); 
     printf("\n ");      } 
     }      SHFT(*ax,*bx,*cx,u) 
     printf("\n ");printf("%lf ",cov[2]);*/        SHFT(*fa,*fb,*fc,fu) 
 /*        } 
   for(i=1; i<= npar; i++) printf("%f ",x[i]);  } 
   goto end;*/  
     return ps;  /*************** linmin ************************/
 }  
   int ncom; 
 /**************** Product of 2 matrices ******************/  double *pcom,*xicom;
   double (*nrfunc)(double []); 
 double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)   
 {  void linmin(double p[], double xi[], int n, double *fret,double (*func)(double [])) 
   /* Computes the matric product of in(1,nrh-nrl+1)(1,nch-ncl+1) times  { 
      b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */    double brent(double ax, double bx, double cx, 
   /* in, b, out are matrice of pointers which should have been initialized                 double (*f)(double), double tol, double *xmin); 
      before: only the contents of out is modified. The function returns    double f1dim(double x); 
      a pointer to pointers identical to out */    void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, 
   long i, j, k;                double *fc, double (*func)(double)); 
   for(i=nrl; i<= nrh; i++)    int j; 
     for(k=ncolol; k<=ncoloh; k++)    double xx,xmin,bx,ax; 
       for(j=ncl,out[i][k]=0.; j<=nch; j++)    double fx,fb,fa;
         out[i][k] +=in[i][j]*b[j][k];   
     ncom=n; 
   return out;    pcom=vector(1,n); 
 }    xicom=vector(1,n); 
     nrfunc=func; 
     for (j=1;j<=n;j++) { 
 /************* Higher Matrix Product ***************/      pcom[j]=p[j]; 
       xicom[j]=xi[j]; 
 double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )    } 
 {    ax=0.0; 
   /* Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' month    xx=1.0; 
      duration (i.e. until    mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim); 
      age (in years)  age+nhstepm*stepm/12) by multiplying nhstepm*hstepm matrices.    *fret=brent(ax,xx,bx,f1dim,TOL,&xmin); 
      Output is stored in matrix po[i][j][h] for h every 'hstepm' step  #ifdef DEBUG
      (typically every 2 years instead of every month which is too big).    printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
      Model is determined by parameters x and covariates have to be    fprintf(ficlog,"retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
      included manually here.  #endif
     for (j=1;j<=n;j++) { 
      */      xi[j] *= xmin; 
       p[j] += xi[j]; 
   int i, j, d, h, k;    } 
   double **out, cov[NCOVMAX];    free_vector(xicom,1,n); 
   double **newm;    free_vector(pcom,1,n); 
   } 
   /* Hstepm could be zero and should return the unit matrix */  
   for (i=1;i<=nlstate+ndeath;i++)  char *asc_diff_time(long time_sec, char ascdiff[])
     for (j=1;j<=nlstate+ndeath;j++){  {
       oldm[i][j]=(i==j ? 1.0 : 0.0);    long sec_left, days, hours, minutes;
       po[i][j][0]=(i==j ? 1.0 : 0.0);    days = (time_sec) / (60*60*24);
     }    sec_left = (time_sec) % (60*60*24);
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */    hours = (sec_left) / (60*60) ;
   for(h=1; h <=nhstepm; h++){    sec_left = (sec_left) %(60*60);
     for(d=1; d <=hstepm; d++){    minutes = (sec_left) /60;
       newm=savm;    sec_left = (sec_left) % (60);
       /* Covariates have to be included here again */    sprintf(ascdiff,"%d day(s) %d hour(s) %d minute(s) %d second(s)",days, hours, minutes, sec_left);  
       cov[1]=1.;    return ascdiff;
       cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;  }
       if (cptcovn>0){  
       for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][k]];  /*************** powell ************************/
     }  void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret, 
       /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/              double (*func)(double [])) 
       /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/  { 
       out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath,    void linmin(double p[], double xi[], int n, double *fret, 
                    pmij(pmmij,cov,ncovmodel,x,nlstate));                double (*func)(double [])); 
       savm=oldm;    int i,ibig,j; 
       oldm=newm;    double del,t,*pt,*ptt,*xit;
     }    double fp,fptt;
     for(i=1; i<=nlstate+ndeath; i++)    double *xits;
       for(j=1;j<=nlstate+ndeath;j++) {    int niterf, itmp;
         po[i][j][h]=newm[i][j];  
         /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);    pt=vector(1,n); 
          */    ptt=vector(1,n); 
       }    xit=vector(1,n); 
   } /* end h */    xits=vector(1,n); 
   return po;    *fret=(*func)(p); 
 }    for (j=1;j<=n;j++) pt[j]=p[j]; 
     for (*iter=1;;++(*iter)) { 
       fp=(*fret); 
 /*************** log-likelihood *************/      ibig=0; 
 double func( double *x)      del=0.0; 
 {      last_time=curr_time;
   int i, ii, j, k, mi, d;      (void) gettimeofday(&curr_time,&tzp);
   double l, ll[NLSTATEMAX], cov[NCOVMAX];      printf("\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);fflush(stdout);
   double **out;      fprintf(ficlog,"\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);
   double sw; /* Sum of weights */      fprintf(ficrespow,"%d %.12f %ld",*iter,*fret,curr_time.tv_sec-start_time.tv_sec);
   double lli; /* Individual log likelihood */      for (i=1;i<=n;i++) {
   long ipmx;        printf(" %d %.12f",i, p[i]);
   /*extern weight */        fprintf(ficlog," %d %.12lf",i, p[i]);
   /* We are differentiating ll according to initial status */        fprintf(ficrespow," %.12lf", p[i]);
   /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/      }
   /*for(i=1;i<imx;i++)      printf("\n");
 printf(" %d\n",s[4][i]);      fprintf(ficlog,"\n");
   */      fprintf(ficrespow,"\n");fflush(ficrespow);
       if(*iter <=3){
   for(k=1; k<=nlstate; k++) ll[k]=0.;        tm = *localtime(&curr_time.tv_sec);
   for (i=1,ipmx=0, sw=0.; i<=imx; i++){        strcpy(strcurr,asctime(&tmf));
        for(mi=1; mi<= wav[i]-1; mi++){  /*       asctime_r(&tm,strcurr); */
       for (ii=1;ii<=nlstate+ndeath;ii++)        forecast_time=curr_time;
         for (j=1;j<=nlstate+ndeath;j++) oldm[ii][j]=(ii==j ? 1.0 : 0.0);        itmp = strlen(strcurr);
             for(d=0; d<dh[mi][i]; d++){        if(strcurr[itmp-1]=='\n')
         newm=savm;          strcurr[itmp-1]='\0';
           cov[1]=1.;        printf("\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
           cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;        fprintf(ficlog,"\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
           if (cptcovn>0){        for(niterf=10;niterf<=30;niterf+=10){
             for (k=1; k<=cptcovn;k++) cov[2+k]=covar[1+k-1][i];          forecast_time.tv_sec=curr_time.tv_sec+(niterf-*iter)*(curr_time.tv_sec-last_time.tv_sec);
             }          tmf = *localtime(&forecast_time.tv_sec);
           out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,  /*      asctime_r(&tmf,strfor); */
                        1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));          strcpy(strfor,asctime(&tmf));
           savm=oldm;          itmp = strlen(strfor);
           oldm=newm;          if(strfor[itmp-1]=='\n')
           strfor[itmp-1]='\0';
           printf("   - if your program needs %d iterations to converge, convergence will be \n   reached in %s or\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
       } /* end mult */          fprintf(ficlog,"   - if your program needs %d iterations to converge, convergence will be \n   reached in %s or\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
            }
       lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);      }
       /* printf(" %f ",out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/      for (i=1;i<=n;i++) { 
       ipmx +=1;        for (j=1;j<=n;j++) xit[j]=xi[j][i]; 
       sw += weight[i];        fptt=(*fret); 
       ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;  #ifdef DEBUG
     } /* end of wave */        printf("fret=%lf \n",*fret);
   } /* end of individual */        fprintf(ficlog,"fret=%lf \n",*fret);
   #endif
   for(k=1,l=0.; k<=nlstate; k++) l += ll[k];        printf("%d",i);fflush(stdout);
   /* printf("l1=%f l2=%f ",ll[1],ll[2]); */        fprintf(ficlog,"%d",i);fflush(ficlog);
   l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */        linmin(p,xit,n,fret,func); 
   return -l;        if (fabs(fptt-(*fret)) > del) { 
 }          del=fabs(fptt-(*fret)); 
           ibig=i; 
         } 
 /*********** Maximum Likelihood Estimation ***************/  #ifdef DEBUG
         printf("%d %.12e",i,(*fret));
 void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))        fprintf(ficlog,"%d %.12e",i,(*fret));
 {        for (j=1;j<=n;j++) {
   int i,j, iter;          xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);
   double **xi,*delti;          printf(" x(%d)=%.12e",j,xit[j]);
   double fret;          fprintf(ficlog," x(%d)=%.12e",j,xit[j]);
   xi=matrix(1,npar,1,npar);        }
   for (i=1;i<=npar;i++)        for(j=1;j<=n;j++) {
     for (j=1;j<=npar;j++)          printf(" p=%.12e",p[j]);
       xi[i][j]=(i==j ? 1.0 : 0.0);          fprintf(ficlog," p=%.12e",p[j]);
   printf("Powell\n");        }
   powell(p,xi,npar,ftol,&iter,&fret,func);        printf("\n");
         fprintf(ficlog,"\n");
    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));  #endif
   fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f ",iter,func(p));      } 
       if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {
 }  #ifdef DEBUG
         int k[2],l;
 /**** Computes Hessian and covariance matrix ***/        k[0]=1;
 void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))        k[1]=-1;
 {        printf("Max: %.12e",(*func)(p));
   double  **a,**y,*x,pd;        fprintf(ficlog,"Max: %.12e",(*func)(p));
   double **hess;        for (j=1;j<=n;j++) {
   int i, j,jk;          printf(" %.12e",p[j]);
   int *indx;          fprintf(ficlog," %.12e",p[j]);
         }
   double hessii(double p[], double delta, int theta, double delti[]);        printf("\n");
   double hessij(double p[], double delti[], int i, int j);        fprintf(ficlog,"\n");
   void lubksb(double **a, int npar, int *indx, double b[]) ;        for(l=0;l<=1;l++) {
   void ludcmp(double **a, int npar, int *indx, double *d) ;          for (j=1;j<=n;j++) {
             ptt[j]=p[j]+(p[j]-pt[j])*k[l];
             printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
   hess=matrix(1,npar,1,npar);            fprintf(ficlog,"l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
           }
   printf("\nCalculation of the hessian matrix. Wait...\n");          printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
   for (i=1;i<=npar;i++){          fprintf(ficlog,"func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
     printf("%d",i);fflush(stdout);        }
     hess[i][i]=hessii(p,ftolhess,i,delti);  #endif
     /*printf(" %f ",p[i]);*/  
   }  
         free_vector(xit,1,n); 
   for (i=1;i<=npar;i++) {        free_vector(xits,1,n); 
     for (j=1;j<=npar;j++)  {        free_vector(ptt,1,n); 
       if (j>i) {        free_vector(pt,1,n); 
         printf(".%d%d",i,j);fflush(stdout);        return; 
         hess[i][j]=hessij(p,delti,i,j);      } 
         hess[j][i]=hess[i][j];      if (*iter == ITMAX) nrerror("powell exceeding maximum iterations."); 
       }      for (j=1;j<=n;j++) { 
     }        ptt[j]=2.0*p[j]-pt[j]; 
   }        xit[j]=p[j]-pt[j]; 
   printf("\n");        pt[j]=p[j]; 
       } 
   printf("\nInverting the hessian to get the covariance matrix. Wait...\n");      fptt=(*func)(ptt); 
        if (fptt < fp) { 
   a=matrix(1,npar,1,npar);        t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt); 
   y=matrix(1,npar,1,npar);        if (t < 0.0) { 
   x=vector(1,npar);          linmin(p,xit,n,fret,func); 
   indx=ivector(1,npar);          for (j=1;j<=n;j++) { 
   for (i=1;i<=npar;i++)            xi[j][ibig]=xi[j][n]; 
     for (j=1;j<=npar;j++) a[i][j]=hess[i][j];            xi[j][n]=xit[j]; 
   ludcmp(a,npar,indx,&pd);          }
   #ifdef DEBUG
   for (j=1;j<=npar;j++) {          printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
     for (i=1;i<=npar;i++) x[i]=0;          fprintf(ficlog,"Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
     x[j]=1;          for(j=1;j<=n;j++){
     lubksb(a,npar,indx,x);            printf(" %.12e",xit[j]);
     for (i=1;i<=npar;i++){            fprintf(ficlog," %.12e",xit[j]);
       matcov[i][j]=x[i];          }
     }          printf("\n");
   }          fprintf(ficlog,"\n");
   #endif
   printf("\n#Hessian matrix#\n");        }
   for (i=1;i<=npar;i++) {      } 
     for (j=1;j<=npar;j++) {    } 
       printf("%.3e ",hess[i][j]);  } 
     }  
     printf("\n");  /**** Prevalence limit (stable prevalence)  ****************/
   }  
   double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)
   /* Recompute Inverse */  {
   for (i=1;i<=npar;i++)    /* Computes the prevalence limit in each live state at age x by left multiplying the unit
     for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];       matrix by transitions matrix until convergence is reached */
   ludcmp(a,npar,indx,&pd);  
     int i, ii,j,k;
   /*  printf("\n#Hessian matrix recomputed#\n");    double min, max, maxmin, maxmax,sumnew=0.;
     double **matprod2();
   for (j=1;j<=npar;j++) {    double **out, cov[NCOVMAX], **pmij();
     for (i=1;i<=npar;i++) x[i]=0;    double **newm;
     x[j]=1;    double agefin, delaymax=50 ; /* Max number of years to converge */
     lubksb(a,npar,indx,x);  
     for (i=1;i<=npar;i++){    for (ii=1;ii<=nlstate+ndeath;ii++)
       y[i][j]=x[i];      for (j=1;j<=nlstate+ndeath;j++){
       printf("%.3e ",y[i][j]);        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     }      }
     printf("\n");  
   }     cov[1]=1.;
   */   
    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
   free_matrix(a,1,npar,1,npar);    for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){
   free_matrix(y,1,npar,1,npar);      newm=savm;
   free_vector(x,1,npar);      /* Covariates have to be included here again */
   free_ivector(indx,1,npar);       cov[2]=agefin;
   free_matrix(hess,1,npar,1,npar);    
         for (k=1; k<=cptcovn;k++) {
           cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
 }          /*      printf("ij=%d k=%d Tvar[k]=%d nbcode=%d cov=%lf codtab[ij][Tvar[k]]=%d \n",ij,k, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k], codtab[ij][Tvar[k]]);*/
         }
 /*************** hessian matrix ****************/        for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
 double hessii( double x[], double delta, int theta, double delti[])        for (k=1; k<=cptcovprod;k++)
 {          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
   int i;  
   int l=1, lmax=20;        /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/
   double k1,k2;        /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/
   double p2[NPARMAX+1];        /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/
   double res;      out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);
   double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;  
   double fx;      savm=oldm;
   int k=0,kmax=10;      oldm=newm;
   double l1;      maxmax=0.;
       for(j=1;j<=nlstate;j++){
   fx=func(x);        min=1.;
   for (i=1;i<=npar;i++) p2[i]=x[i];        max=0.;
   for(l=0 ; l <=lmax; l++){        for(i=1; i<=nlstate; i++) {
     l1=pow(10,l);          sumnew=0;
     delts=delt;          for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];
     for(k=1 ; k <kmax; k=k+1){          prlim[i][j]= newm[i][j]/(1-sumnew);
       delt = delta*(l1*k);          max=FMAX(max,prlim[i][j]);
       p2[theta]=x[theta] +delt;          min=FMIN(min,prlim[i][j]);
       k1=func(p2)-fx;        }
       p2[theta]=x[theta]-delt;        maxmin=max-min;
       k2=func(p2)-fx;        maxmax=FMAX(maxmax,maxmin);
       /*res= (k1-2.0*fx+k2)/delt/delt; */      }
       res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */      if(maxmax < ftolpl){
              return prlim;
 #ifdef DEBUG      }
       printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);    }
 #endif  }
       /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */  
       if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){  /*************** transition probabilities ***************/ 
         k=kmax;  
       }  double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )
       else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */  {
         k=kmax; l=lmax*10.;    double s1, s2;
       }    /*double t34;*/
       else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){    int i,j,j1, nc, ii, jj;
         delts=delt;  
       }      for(i=1; i<= nlstate; i++){
     }      for(j=1; j<i;j++){
   }        for (nc=1, s2=0.;nc <=ncovmodel; nc++){
   delti[theta]=delts;          /*s2 += param[i][j][nc]*cov[nc];*/
   return res;          s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
            /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/
 }        }
         ps[i][j]=s2;
 double hessij( double x[], double delti[], int thetai,int thetaj)        /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/
 {      }
   int i;      for(j=i+1; j<=nlstate+ndeath;j++){
   int l=1, l1, lmax=20;        for (nc=1, s2=0.;nc <=ncovmodel; nc++){
   double k1,k2,k3,k4,res,fx;          s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
   double p2[NPARMAX+1];          /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/
   int k;        }
         ps[i][j]=s2;
   fx=func(x);      }
   for (k=1; k<=2; k++) {    }
     for (i=1;i<=npar;i++) p2[i]=x[i];      /*ps[3][2]=1;*/
     p2[thetai]=x[thetai]+delti[thetai]/k;  
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;    for(i=1; i<= nlstate; i++){
     k1=func(p2)-fx;       s1=0;
        for(j=1; j<i; j++)
     p2[thetai]=x[thetai]+delti[thetai]/k;        s1+=exp(ps[i][j]);
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;      for(j=i+1; j<=nlstate+ndeath; j++)
     k2=func(p2)-fx;        s1+=exp(ps[i][j]);
        ps[i][i]=1./(s1+1.);
     p2[thetai]=x[thetai]-delti[thetai]/k;      for(j=1; j<i; j++)
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;        ps[i][j]= exp(ps[i][j])*ps[i][i];
     k3=func(p2)-fx;      for(j=i+1; j<=nlstate+ndeath; j++)
          ps[i][j]= exp(ps[i][j])*ps[i][i];
     p2[thetai]=x[thetai]-delti[thetai]/k;      /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;    } /* end i */
     k4=func(p2)-fx;  
     res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */    for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){
 #ifdef DEBUG      for(jj=1; jj<= nlstate+ndeath; jj++){
     printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);        ps[ii][jj]=0;
 #endif        ps[ii][ii]=1;
   }      }
   return res;    }
 }  
   
 /************** Inverse of matrix **************/    /*   for(ii=1; ii<= nlstate+ndeath; ii++){
 void ludcmp(double **a, int n, int *indx, double *d)      for(jj=1; jj<= nlstate+ndeath; jj++){
 {       printf("%lf ",ps[ii][jj]);
   int i,imax,j,k;     }
   double big,dum,sum,temp;      printf("\n ");
   double *vv;      }
        printf("\n ");printf("%lf ",cov[2]);*/
   vv=vector(1,n);  /*
   *d=1.0;    for(i=1; i<= npar; i++) printf("%f ",x[i]);
   for (i=1;i<=n;i++) {    goto end;*/
     big=0.0;      return ps;
     for (j=1;j<=n;j++)  }
       if ((temp=fabs(a[i][j])) > big) big=temp;  
     if (big == 0.0) nrerror("Singular matrix in routine ludcmp");  /**************** Product of 2 matrices ******************/
     vv[i]=1.0/big;  
   }  double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)
   for (j=1;j<=n;j++) {  {
     for (i=1;i<j;i++) {    /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times
       sum=a[i][j];       b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */
       for (k=1;k<i;k++) sum -= a[i][k]*a[k][j];    /* in, b, out are matrice of pointers which should have been initialized 
       a[i][j]=sum;       before: only the contents of out is modified. The function returns
     }       a pointer to pointers identical to out */
     big=0.0;    long i, j, k;
     for (i=j;i<=n;i++) {    for(i=nrl; i<= nrh; i++)
       sum=a[i][j];      for(k=ncolol; k<=ncoloh; k++)
       for (k=1;k<j;k++)        for(j=ncl,out[i][k]=0.; j<=nch; j++)
         sum -= a[i][k]*a[k][j];          out[i][k] +=in[i][j]*b[j][k];
       a[i][j]=sum;  
       if ( (dum=vv[i]*fabs(sum)) >= big) {    return out;
         big=dum;  }
         imax=i;  
       }  
     }  /************* Higher Matrix Product ***************/
     if (j != imax) {  
       for (k=1;k<=n;k++) {  double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )
         dum=a[imax][k];  {
         a[imax][k]=a[j][k];    /* Computes the transition matrix starting at age 'age' over 
         a[j][k]=dum;       'nhstepm*hstepm*stepm' months (i.e. until
       }       age (in years)  age+nhstepm*hstepm*stepm/12) by multiplying 
       *d = -(*d);       nhstepm*hstepm matrices. 
       vv[imax]=vv[j];       Output is stored in matrix po[i][j][h] for h every 'hstepm' step 
     }       (typically every 2 years instead of every month which is too big 
     indx[j]=imax;       for the memory).
     if (a[j][j] == 0.0) a[j][j]=TINY;       Model is determined by parameters x and covariates have to be 
     if (j != n) {       included manually here. 
       dum=1.0/(a[j][j]);  
       for (i=j+1;i<=n;i++) a[i][j] *= dum;       */
     }  
   }    int i, j, d, h, k;
   free_vector(vv,1,n);  /* Doesn't work */    double **out, cov[NCOVMAX];
 ;    double **newm;
 }  
     /* Hstepm could be zero and should return the unit matrix */
 void lubksb(double **a, int n, int *indx, double b[])    for (i=1;i<=nlstate+ndeath;i++)
 {      for (j=1;j<=nlstate+ndeath;j++){
   int i,ii=0,ip,j;        oldm[i][j]=(i==j ? 1.0 : 0.0);
   double sum;        po[i][j][0]=(i==j ? 1.0 : 0.0);
        }
   for (i=1;i<=n;i++) {    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
     ip=indx[i];    for(h=1; h <=nhstepm; h++){
     sum=b[ip];      for(d=1; d <=hstepm; d++){
     b[ip]=b[i];        newm=savm;
     if (ii)        /* Covariates have to be included here again */
       for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j];        cov[1]=1.;
     else if (sum) ii=i;        cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;
     b[i]=sum;        for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
   }        for (k=1; k<=cptcovage;k++)
   for (i=n;i>=1;i--) {          cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
     sum=b[i];        for (k=1; k<=cptcovprod;k++)
     for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j];          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
     b[i]=sum/a[i][i];  
   }  
 }        /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/
         /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/
 /************ Frequencies ********************/        out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, 
 void  freqsummary(char fileres[], int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax)                     pmij(pmmij,cov,ncovmodel,x,nlstate));
 {  /* Some frequencies */        savm=oldm;
          oldm=newm;
   int i, m, jk, k1, i1, j1, bool, z1,z2,j;      }
   double ***freq; /* Frequencies */      for(i=1; i<=nlstate+ndeath; i++)
   double *pp;        for(j=1;j<=nlstate+ndeath;j++) {
   double pos;          po[i][j][h]=newm[i][j];
   FILE *ficresp;          /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);
   char fileresp[FILENAMELENGTH];           */
         }
   pp=vector(1,nlstate);    } /* end h */
     return po;
   strcpy(fileresp,"p");  }
   strcat(fileresp,fileres);  
   if((ficresp=fopen(fileresp,"w"))==NULL) {  
     printf("Problem with prevalence resultfile: %s\n", fileresp);  /*************** log-likelihood *************/
     exit(0);  double func( double *x)
   }  {
   freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);    int i, ii, j, k, mi, d, kk;
   j1=0;    double l, ll[NLSTATEMAX], cov[NCOVMAX];
     double **out;
   j=cptcovn;    double sw; /* Sum of weights */
   if (cptcovn<1) {j=1;ncodemax[1]=1;}    double lli; /* Individual log likelihood */
     int s1, s2;
   for(k1=1; k1<=j;k1++){    double bbh, survp;
    for(i1=1; i1<=ncodemax[k1];i1++){    long ipmx;
        j1++;    /*extern weight */
     /* We are differentiating ll according to initial status */
         for (i=-1; i<=nlstate+ndeath; i++)      /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
          for (jk=-1; jk<=nlstate+ndeath; jk++)      /*for(i=1;i<imx;i++) 
            for(m=agemin; m <= agemax+3; m++)      printf(" %d\n",s[4][i]);
              freq[i][jk][m]=0;    */
            cov[1]=1.;
        for (i=1; i<=imx; i++) {  
          bool=1;    for(k=1; k<=nlstate; k++) ll[k]=0.;
          if  (cptcovn>0) {  
            for (z1=1; z1<=cptcovn; z1++)    if(mle==1){
              if (covar[Tvar[z1]][i]!= nbcode[Tvar[z1]][codtab[j1][z1]]) bool=0;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
          }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
           if (bool==1) {        for(mi=1; mi<= wav[i]-1; mi++){
            for(m=firstpass; m<=lastpass-1; m++){          for (ii=1;ii<=nlstate+ndeath;ii++)
              if(agev[m][i]==0) agev[m][i]=agemax+1;            for (j=1;j<=nlstate+ndeath;j++){
              if(agev[m][i]==1) agev[m][i]=agemax+2;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
              freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];              savm[ii][j]=(ii==j ? 1.0 : 0.0);
              freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];            }
            }          for(d=0; d<dh[mi][i]; d++){
          }            newm=savm;
        }            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
         if  (cptcovn>0) {            for (kk=1; kk<=cptcovage;kk++) {
          fprintf(ficresp, "\n#Variable");              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
          for (z1=1; z1<=cptcovn; z1++) fprintf(ficresp, " V%d=%d",Tvar[z1],nbcode[Tvar[z1]][codtab[j1][z1]]);            }
        }            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
        fprintf(ficresp, "\n#");                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
        for(i=1; i<=nlstate;i++)            savm=oldm;
          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);            oldm=newm;
        fprintf(ficresp, "\n");          } /* end mult */
                
   for(i=(int)agemin; i <= (int)agemax+3; i++){          /*lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/ /* Original formula */
     if(i==(int)agemax+3)          /* But now since version 0.9 we anticipate for bias and large stepm.
       printf("Total");           * If stepm is larger than one month (smallest stepm) and if the exact delay 
     else           * (in months) between two waves is not a multiple of stepm, we rounded to 
       printf("Age %d", i);           * the nearest (and in case of equal distance, to the lowest) interval but now
     for(jk=1; jk <=nlstate ; jk++){           * we keep into memory the bias bh[mi][i] and also the previous matrix product
       for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)           * (i.e to dh[mi][i]-1) saved in 'savm'. The we inter(extra)polate the
         pp[jk] += freq[jk][m][i];           * probability in order to take into account the bias as a fraction of the way
     }           * from savm to out if bh is neagtive or even beyond if bh is positive. bh varies
     for(jk=1; jk <=nlstate ; jk++){           * -stepm/2 to stepm/2 .
       for(m=-1, pos=0; m <=0 ; m++)           * For stepm=1 the results are the same as for previous versions of Imach.
         pos += freq[jk][m][i];           * For stepm > 1 the results are less biased than in previous versions. 
       if(pp[jk]>=1.e-10)           */
         printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);          s1=s[mw[mi][i]][i];
       else          s2=s[mw[mi+1][i]][i];
         printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);          bbh=(double)bh[mi][i]/(double)stepm; 
     }          /* bias is positive if real duration
     for(jk=1; jk <=nlstate ; jk++){           * is higher than the multiple of stepm and negative otherwise.
       for(m=1, pp[jk]=0; m <=nlstate+ndeath; m++)           */
         pp[jk] += freq[jk][m][i];          /* lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2]));*/
     }          if( s2 > nlstate){ 
     for(jk=1,pos=0; jk <=nlstate ; jk++)            /* i.e. if s2 is a death state and if the date of death is known then the contribution
       pos += pp[jk];               to the likelihood is the probability to die between last step unit time and current 
     for(jk=1; jk <=nlstate ; jk++){               step unit time, which is also the differences between probability to die before dh 
       if(pos>=1.e-5)               and probability to die before dh-stepm . 
         printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);               In version up to 0.92 likelihood was computed
       else          as if date of death was unknown. Death was treated as any other
         printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);          health state: the date of the interview describes the actual state
       if( i <= (int) agemax){          and not the date of a change in health state. The former idea was
         if(pos>=1.e-5)          to consider that at each interview the state was recorded
           fprintf(ficresp," %d %.5f %.0f %.0f",i,pp[jk]/pos, pp[jk],pos);          (healthy, disable or death) and IMaCh was corrected; but when we
       else          introduced the exact date of death then we should have modified
           fprintf(ficresp," %d NaNq %.0f %.0f",i,pp[jk],pos);          the contribution of an exact death to the likelihood. This new
       }          contribution is smaller and very dependent of the step unit
     }          stepm. It is no more the probability to die between last interview
     for(jk=-1; jk <=nlstate+ndeath; jk++)          and month of death but the probability to survive from last
       for(m=-1; m <=nlstate+ndeath; m++)          interview up to one month before death multiplied by the
         if(freq[jk][m][i] !=0 ) printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);          probability to die within a month. Thanks to Chris
     if(i <= (int) agemax)          Jackson for correcting this bug.  Former versions increased
       fprintf(ficresp,"\n");          mortality artificially. The bad side is that we add another loop
     printf("\n");          which slows down the processing. The difference can be up to 10%
     }          lower mortality.
     }            */
  }            lli=log(out[s1][s2] - savm[s1][s2]);
            }else{
   fclose(ficresp);            lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);            /*  lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2]));*/ /* linear interpolation */
   free_vector(pp,1,nlstate);          } 
           /*lli=(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]);*/
 }  /* End of Freq */          /*if(lli ==000.0)*/
           /*printf("bbh= %f lli=%f savm=%f out=%f %d\n",bbh,lli,savm[s1][s2], out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]],i); */
 /************* Waves Concatenation ***************/          ipmx +=1;
           sw += weight[i];
 void  concatwav(int wav[], int **dh, int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
 {        } /* end of wave */
   /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.      } /* end of individual */
      Death is a valid wave (if date is known).    }  else if(mle==2){
      mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
      dh[m][i] of dh[mw[mi][i][i] is the delay between two effective waves m=mw[mi][i]        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
      and mw[mi+1][i]. dh depends on stepm.        for(mi=1; mi<= wav[i]-1; mi++){
      */          for (ii=1;ii<=nlstate+ndeath;ii++)
             for (j=1;j<=nlstate+ndeath;j++){
   int i, mi, m;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
 float sum=0.;            }
           for(d=0; d<=dh[mi][i]; d++){
   for(i=1; i<=imx; i++){            newm=savm;
     mi=0;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     m=firstpass;            for (kk=1; kk<=cptcovage;kk++) {
     while(s[m][i] <= nlstate){              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       if(s[m][i]>=1)            }
         mw[++mi][i]=m;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
       if(m >=lastpass)                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
         break;            savm=oldm;
       else            oldm=newm;
         m++;          } /* end mult */
     }/* end while */        
     if (s[m][i] > nlstate){          s1=s[mw[mi][i]][i];
       mi++;     /* Death is another wave */          s2=s[mw[mi+1][i]][i];
       /* if(mi==0)  never been interviewed correctly before death */          bbh=(double)bh[mi][i]/(double)stepm; 
          /* Only death is a correct wave */          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
       mw[mi][i]=m;          ipmx +=1;
     }          sw += weight[i];
           ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
     wav[i]=mi;        } /* end of wave */
     if(mi==0)      } /* end of individual */
       printf("Warning, no any valid information for:%d line=%d\n",num[i],i);    }  else if(mle==3){  /* exponential inter-extrapolation */
   }      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   for(i=1; i<=imx; i++){        for(mi=1; mi<= wav[i]-1; mi++){
     for(mi=1; mi<wav[i];mi++){          for (ii=1;ii<=nlstate+ndeath;ii++)
       if (stepm <=0)            for (j=1;j<=nlstate+ndeath;j++){
         dh[mi][i]=1;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       else{              savm[ii][j]=(ii==j ? 1.0 : 0.0);
         if (s[mw[mi+1][i]][i] > nlstate) {            }
           j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12);          for(d=0; d<dh[mi][i]; d++){
           if(j=0) j=1;  /* Survives at least one month after exam */            newm=savm;
         }            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
         else{            for (kk=1; kk<=cptcovage;kk++) {
           j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
           k=k+1;            }
           if (j >= jmax) jmax=j;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
           else if (j <= jmin)jmin=j;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
           sum=sum+j;            savm=oldm;
         }            oldm=newm;
         jk= j/stepm;          } /* end mult */
         jl= j -jk*stepm;        
         ju= j -(jk+1)*stepm;          s1=s[mw[mi][i]][i];
         if(jl <= -ju)          s2=s[mw[mi+1][i]][i];
           dh[mi][i]=jk;          bbh=(double)bh[mi][i]/(double)stepm; 
         else          lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
           dh[mi][i]=jk+1;          ipmx +=1;
         if(dh[mi][i]==0)          sw += weight[i];
           dh[mi][i]=1; /* At least one step */          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       }        } /* end of wave */
     }      } /* end of individual */
   }    }else if (mle==4){  /* ml=4 no inter-extrapolation */
   printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,sum/k);      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
 }        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
 /*********** Tricode ****************************/        for(mi=1; mi<= wav[i]-1; mi++){
 void tricode(int *Tvar, int **nbcode, int imx)          for (ii=1;ii<=nlstate+ndeath;ii++)
 {            for (j=1;j<=nlstate+ndeath;j++){
   int Ndum[80],ij, k, j, i;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   int cptcode=0;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
   for (k=0; k<79; k++) Ndum[k]=0;            }
   for (k=1; k<=7; k++) ncodemax[k]=0;          for(d=0; d<dh[mi][i]; d++){
              newm=savm;
   for (j=1; j<=cptcovn; j++) {            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     for (i=1; i<=imx; i++) {            for (kk=1; kk<=cptcovage;kk++) {
       ij=(int)(covar[Tvar[j]][i]);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       Ndum[ij]++;            }
       if (ij > cptcode) cptcode=ij;          
     }            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     /*printf("cptcode=%d cptcovn=%d ",cptcode,cptcovn);*/                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
     for (i=0; i<=cptcode; i++) {            savm=oldm;
       if(Ndum[i]!=0) ncodemax[j]++;            oldm=newm;
     }          } /* end mult */
          
     ij=1;          s1=s[mw[mi][i]][i];
     for (i=1; i<=ncodemax[j]; i++) {          s2=s[mw[mi+1][i]][i];
       for (k=0; k<=79; k++) {          if( s2 > nlstate){ 
         if (Ndum[k] != 0) {            lli=log(out[s1][s2] - savm[s1][s2]);
           nbcode[Tvar[j]][ij]=k;          }else{
           ij++;            lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
         }          }
         if (ij > ncodemax[j]) break;          ipmx +=1;
       }            sw += weight[i];
     }          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   }    /*      printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
         } /* end of wave */
   }      } /* end of individual */
     }else{  /* ml=5 no inter-extrapolation no jackson =0.8a */
 /*********** Health Expectancies ****************/      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
 void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij)        for(mi=1; mi<= wav[i]-1; mi++){
 {          for (ii=1;ii<=nlstate+ndeath;ii++)
   /* Health expectancies */            for (j=1;j<=nlstate+ndeath;j++){
   int i, j, nhstepm, hstepm, h;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   double age, agelim,hf;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
   double ***p3mat;            }
            for(d=0; d<dh[mi][i]; d++){
   fprintf(ficreseij,"# Health expectancies\n");            newm=savm;
   fprintf(ficreseij,"# Age");            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   for(i=1; i<=nlstate;i++)            for (kk=1; kk<=cptcovage;kk++) {
     for(j=1; j<=nlstate;j++)              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       fprintf(ficreseij," %1d-%1d",i,j);            }
   fprintf(ficreseij,"\n");          
             out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   hstepm=1*YEARM; /*  Every j years of age (in month) */                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */            savm=oldm;
             oldm=newm;
   agelim=AGESUP;          } /* end mult */
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */        
     /* nhstepm age range expressed in number of stepm */          s1=s[mw[mi][i]][i];
     nhstepm=(int) rint((agelim-age)*YEARM/stepm);          s2=s[mw[mi+1][i]][i];
     /* Typically if 20 years = 20*12/6=40 stepm */          lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
     if (stepm >= YEARM) hstepm=1;          ipmx +=1;
     nhstepm = nhstepm/hstepm;/* Expressed in hstepm, typically 40/4=10 */          sw += weight[i];
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
     /* Computed by stepm unit matrices, product of hstepm matrices, stored          /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]);*/
        in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */        } /* end of wave */
     hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);        } /* end of individual */
     } /* End of if */
     for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
     for(i=1; i<=nlstate;i++)    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
       for(j=1; j<=nlstate;j++)    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
         for (h=0, eij[i][j][(int)age]=0; h<=nhstepm; h++){    return -l;
           eij[i][j][(int)age] +=p3mat[i][j][h];  }
         }  
      /*************** log-likelihood *************/
     hf=1;  double funcone( double *x)
     if (stepm >= YEARM) hf=stepm/YEARM;  {
     fprintf(ficreseij,"%.0f",age );    /* Same as likeli but slower because of a lot of printf and if */
     for(i=1; i<=nlstate;i++)    int i, ii, j, k, mi, d, kk;
       for(j=1; j<=nlstate;j++){    double l, ll[NLSTATEMAX], cov[NCOVMAX];
         fprintf(ficreseij," %.4f", hf*eij[i][j][(int)age]);    double **out;
       }    double lli; /* Individual log likelihood */
     fprintf(ficreseij,"\n");    double llt;
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    int s1, s2;
   }    double bbh, survp;
 }    /*extern weight */
     /* We are differentiating ll according to initial status */
 /************ Variance ******************/    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
 void varevsij(char fileres[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)    /*for(i=1;i<imx;i++) 
 {      printf(" %d\n",s[4][i]);
   /* Variance of health expectancies */    */
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/    cov[1]=1.;
   double **newm;  
   double **dnewm,**doldm;    for(k=1; k<=nlstate; k++) ll[k]=0.;
   int i, j, nhstepm, hstepm, h;  
   int k, cptcode;    for (i=1,ipmx=0, sw=0.; i<=imx; i++){
    double *xp;      for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
   double **gp, **gm;      for(mi=1; mi<= wav[i]-1; mi++){
   double ***gradg, ***trgradg;        for (ii=1;ii<=nlstate+ndeath;ii++)
   double ***p3mat;          for (j=1;j<=nlstate+ndeath;j++){
   double age,agelim;            oldm[ii][j]=(ii==j ? 1.0 : 0.0);
   int theta;            savm[ii][j]=(ii==j ? 1.0 : 0.0);
           }
    fprintf(ficresvij,"# Covariances of life expectancies\n");        for(d=0; d<dh[mi][i]; d++){
   fprintf(ficresvij,"# Age");          newm=savm;
   for(i=1; i<=nlstate;i++)          cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     for(j=1; j<=nlstate;j++)          for (kk=1; kk<=cptcovage;kk++) {
       fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);            cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
   fprintf(ficresvij,"\n");          }
           out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   xp=vector(1,npar);                       1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   dnewm=matrix(1,nlstate,1,npar);          savm=oldm;
   doldm=matrix(1,nlstate,1,nlstate);          oldm=newm;
          } /* end mult */
   hstepm=1*YEARM; /* Every year of age */        
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */        s1=s[mw[mi][i]][i];
   agelim = AGESUP;        s2=s[mw[mi+1][i]][i];
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */        bbh=(double)bh[mi][i]/(double)stepm; 
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */        /* bias is positive if real duration
     if (stepm >= YEARM) hstepm=1;         * is higher than the multiple of stepm and negative otherwise.
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */         */
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);        if( s2 > nlstate && (mle <5) ){  /* Jackson */
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate);          lli=log(out[s1][s2] - savm[s1][s2]);
     gp=matrix(0,nhstepm,1,nlstate);        } else if (mle==1){
     gm=matrix(0,nhstepm,1,nlstate);          lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
         } else if(mle==2){
     for(theta=1; theta <=npar; theta++){          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
       for(i=1; i<=npar; i++){ /* Computes gradient */        } else if(mle==3){  /* exponential inter-extrapolation */
         xp[i] = x[i] + (i==theta ?delti[theta]:0);          lli= (savm[s1][s2]>(double)1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
       }        } else if (mle==4){  /* mle=4 no inter-extrapolation */
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);            lli=log(out[s1][s2]); /* Original formula */
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);        } else{  /* ml>=5 no inter-extrapolation no jackson =0.8a */
       for(j=1; j<= nlstate; j++){          lli=log(out[s1][s2]); /* Original formula */
         for(h=0; h<=nhstepm; h++){        } /* End of if */
           for(i=1, gp[h][j]=0.;i<=nlstate;i++)        ipmx +=1;
             gp[h][j] += prlim[i][i]*p3mat[i][j][h];        sw += weight[i];
         }        ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       }  /*       printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
            if(globpr){
       for(i=1; i<=npar; i++) /* Computes gradient */          fprintf(ficresilk,"%9d %6d %1d %1d %1d %1d %3d %10.6f %6.4f\
         xp[i] = x[i] - (i==theta ?delti[theta]:0);   %10.6f %10.6f %10.6f ", \
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);                    num[i],i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);                  2*weight[i]*lli,out[s1][s2],savm[s1][s2]);
       for(j=1; j<= nlstate; j++){          for(k=1,llt=0.,l=0.; k<=nlstate; k++){
         for(h=0; h<=nhstepm; h++){            llt +=ll[k]*gipmx/gsw;
           for(i=1, gm[h][j]=0.;i<=nlstate;i++)            fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw);
             gm[h][j] += prlim[i][i]*p3mat[i][j][h];          }
         }          fprintf(ficresilk," %10.6f\n", -llt);
       }        }
       for(j=1; j<= nlstate; j++)      } /* end of wave */
         for(h=0; h<=nhstepm; h++){    } /* end of individual */
           gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
         }    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
     } /* End theta */    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
     if(globpr==0){ /* First time we count the contributions and weights */
     trgradg =ma3x(0,nhstepm,1,nlstate,1,npar);      gipmx=ipmx;
       gsw=sw;
     for(h=0; h<=nhstepm; h++)    }
       for(j=1; j<=nlstate;j++)    return -l;
         for(theta=1; theta <=npar; theta++)  }
           trgradg[h][j][theta]=gradg[h][theta][j];  
   
     for(i=1;i<=nlstate;i++)  /*************** function likelione ***********/
       for(j=1;j<=nlstate;j++)  void likelione(FILE *ficres,double p[], int npar, int nlstate, int *globpri, long *ipmx, double *sw, double *fretone, double (*funcone)(double []))
         vareij[i][j][(int)age] =0.;  {
     for(h=0;h<=nhstepm;h++){    /* This routine should help understanding what is done with 
       for(k=0;k<=nhstepm;k++){       the selection of individuals/waves and
         matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);       to check the exact contribution to the likelihood.
         matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);       Plotting could be done.
         for(i=1;i<=nlstate;i++)     */
           for(j=1;j<=nlstate;j++)    int k;
             vareij[i][j][(int)age] += doldm[i][j];  
       }    if(*globpri !=0){ /* Just counts and sums, no printings */
     }      strcpy(fileresilk,"ilk"); 
     h=1;      strcat(fileresilk,fileres);
     if (stepm >= YEARM) h=stepm/YEARM;      if((ficresilk=fopen(fileresilk,"w"))==NULL) {
     fprintf(ficresvij,"%.0f ",age );        printf("Problem with resultfile: %s\n", fileresilk);
     for(i=1; i<=nlstate;i++)        fprintf(ficlog,"Problem with resultfile: %s\n", fileresilk);
       for(j=1; j<=nlstate;j++){      }
         fprintf(ficresvij," %.4f", h*vareij[i][j][(int)age]);      fprintf(ficresilk, "#individual(line's_record) s1 s2 wave# effective_wave# number_of_matrices_product pij weight -2ln(pij)*weight 0pij_x 0pij_(x-stepm) cumulating_loglikeli_by_health_state(reweighted=-2ll*weightXnumber_of_contribs/sum_of_weights) and_total\n");
       }      fprintf(ficresilk, "#num_i i s1 s2 mi mw dh likeli weight 2wlli out sav ");
     fprintf(ficresvij,"\n");      /*  i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],2*weight[i]*lli,out[s1][s2],savm[s1][s2]); */
     free_matrix(gp,0,nhstepm,1,nlstate);      for(k=1; k<=nlstate; k++) 
     free_matrix(gm,0,nhstepm,1,nlstate);        fprintf(ficresilk," -2*gipw/gsw*weight*ll[%d]++",k);
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);      fprintf(ficresilk," -2*gipw/gsw*weight*ll(total)\n");
     free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);    }
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);  
   } /* End age */    *fretone=(*funcone)(p);
      if(*globpri !=0){
   free_vector(xp,1,npar);      fclose(ficresilk);
   free_matrix(doldm,1,nlstate,1,npar);      fprintf(fichtm,"\n<br>File of contributions to the likelihood: <a href=\"%s\">%s</a><br>\n",subdirf(fileresilk),subdirf(fileresilk));
   free_matrix(dnewm,1,nlstate,1,nlstate);      fflush(fichtm); 
     } 
 }    return;
   }
 /************ Variance of prevlim ******************/  
 void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)  
 {  /*********** Maximum Likelihood Estimation ***************/
   /* Variance of prevalence limit */  
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/  void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))
   double **newm;  {
   double **dnewm,**doldm;    int i,j, iter;
   int i, j, nhstepm, hstepm;    double **xi;
   int k, cptcode;    double fret;
   double *xp;    double fretone; /* Only one call to likelihood */
   double *gp, *gm;    char filerespow[FILENAMELENGTH];
   double **gradg, **trgradg;    xi=matrix(1,npar,1,npar);
   double age,agelim;    for (i=1;i<=npar;i++)
   int theta;      for (j=1;j<=npar;j++)
            xi[i][j]=(i==j ? 1.0 : 0.0);
   fprintf(ficresvpl,"# Standard deviation of prevalences limit\n");    printf("Powell\n");  fprintf(ficlog,"Powell\n");
   fprintf(ficresvpl,"# Age");    strcpy(filerespow,"pow"); 
   for(i=1; i<=nlstate;i++)    strcat(filerespow,fileres);
       fprintf(ficresvpl," %1d-%1d",i,i);    if((ficrespow=fopen(filerespow,"w"))==NULL) {
   fprintf(ficresvpl,"\n");      printf("Problem with resultfile: %s\n", filerespow);
       fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
   xp=vector(1,npar);    }
   dnewm=matrix(1,nlstate,1,npar);    fprintf(ficrespow,"# Powell\n# iter -2*LL");
   doldm=matrix(1,nlstate,1,nlstate);    for (i=1;i<=nlstate;i++)
        for(j=1;j<=nlstate+ndeath;j++)
   hstepm=1*YEARM; /* Every year of age */        if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */    fprintf(ficrespow,"\n");
   agelim = AGESUP;  
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */    powell(p,xi,npar,ftol,&iter,&fret,func);
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */  
     if (stepm >= YEARM) hstepm=1;    fclose(ficrespow);
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));
     gradg=matrix(1,npar,1,nlstate);    fprintf(ficlog,"\n#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
     gp=vector(1,nlstate);    fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
     gm=vector(1,nlstate);  
   }
     for(theta=1; theta <=npar; theta++){  
       for(i=1; i<=npar; i++){ /* Computes gradient */  /**** Computes Hessian and covariance matrix ***/
         xp[i] = x[i] + (i==theta ?delti[theta]:0);  void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))
       }  {
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    double  **a,**y,*x,pd;
       for(i=1;i<=nlstate;i++)    double **hess;
         gp[i] = prlim[i][i];    int i, j,jk;
        int *indx;
       for(i=1; i<=npar; i++) /* Computes gradient */  
         xp[i] = x[i] - (i==theta ?delti[theta]:0);    double hessii(double p[], double delta, int theta, double delti[]);
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);    double hessij(double p[], double delti[], int i, int j);
       for(i=1;i<=nlstate;i++)    void lubksb(double **a, int npar, int *indx, double b[]) ;
         gm[i] = prlim[i][i];    void ludcmp(double **a, int npar, int *indx, double *d) ;
   
       for(i=1;i<=nlstate;i++)    hess=matrix(1,npar,1,npar);
         gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];  
     } /* End theta */    printf("\nCalculation of the hessian matrix. Wait...\n");
     fprintf(ficlog,"\nCalculation of the hessian matrix. Wait...\n");
     trgradg =matrix(1,nlstate,1,npar);    for (i=1;i<=npar;i++){
       printf("%d",i);fflush(stdout);
     for(j=1; j<=nlstate;j++)      fprintf(ficlog,"%d",i);fflush(ficlog);
       for(theta=1; theta <=npar; theta++)      hess[i][i]=hessii(p,ftolhess,i,delti);
         trgradg[j][theta]=gradg[theta][j];      /*printf(" %f ",p[i]);*/
       /*printf(" %lf ",hess[i][i]);*/
     for(i=1;i<=nlstate;i++)    }
       varpl[i][(int)age] =0.;    
     matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);    for (i=1;i<=npar;i++) {
     matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);      for (j=1;j<=npar;j++)  {
     for(i=1;i<=nlstate;i++)        if (j>i) { 
       varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */          printf(".%d%d",i,j);fflush(stdout);
           fprintf(ficlog,".%d%d",i,j);fflush(ficlog);
     fprintf(ficresvpl,"%.0f ",age );          hess[i][j]=hessij(p,delti,i,j);
     for(i=1; i<=nlstate;i++)          hess[j][i]=hess[i][j];    
       fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));          /*printf(" %lf ",hess[i][j]);*/
     fprintf(ficresvpl,"\n");        }
     free_vector(gp,1,nlstate);      }
     free_vector(gm,1,nlstate);    }
     free_matrix(gradg,1,npar,1,nlstate);    printf("\n");
     free_matrix(trgradg,1,nlstate,1,npar);    fprintf(ficlog,"\n");
   } /* End age */  
     printf("\nInverting the hessian to get the covariance matrix. Wait...\n");
   free_vector(xp,1,npar);    fprintf(ficlog,"\nInverting the hessian to get the covariance matrix. Wait...\n");
   free_matrix(doldm,1,nlstate,1,npar);    
   free_matrix(dnewm,1,nlstate,1,nlstate);    a=matrix(1,npar,1,npar);
     y=matrix(1,npar,1,npar);
 }    x=vector(1,npar);
     indx=ivector(1,npar);
     for (i=1;i<=npar;i++)
       for (j=1;j<=npar;j++) a[i][j]=hess[i][j];
 /***********************************************/    ludcmp(a,npar,indx,&pd);
 /**************** Main Program *****************/  
 /***********************************************/    for (j=1;j<=npar;j++) {
       for (i=1;i<=npar;i++) x[i]=0;
 /*int main(int argc, char *argv[])*/      x[j]=1;
 int main()      lubksb(a,npar,indx,x);
 {      for (i=1;i<=npar;i++){ 
         matcov[i][j]=x[i];
   int i,j, k, n=MAXN,iter,m,size,cptcode, aaa, cptcod;      }
   double agedeb, agefin,hf;    }
   double agemin=1.e20, agemax=-1.e20;  
     printf("\n#Hessian matrix#\n");
   double fret;    fprintf(ficlog,"\n#Hessian matrix#\n");
   double **xi,tmp,delta;    for (i=1;i<=npar;i++) { 
       for (j=1;j<=npar;j++) { 
   double dum; /* Dummy variable */        printf("%.3e ",hess[i][j]);
   double ***p3mat;        fprintf(ficlog,"%.3e ",hess[i][j]);
   int *indx;      }
   char line[MAXLINE], linepar[MAXLINE];      printf("\n");
   char title[MAXLINE];      fprintf(ficlog,"\n");
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];    }
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH];  
   char filerest[FILENAMELENGTH];    /* Recompute Inverse */
   char fileregp[FILENAMELENGTH];    for (i=1;i<=npar;i++)
   char path[80],pathc[80],pathcd[80],pathtot[80],model[20];      for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];
   int firstobs=1, lastobs=10;    ludcmp(a,npar,indx,&pd);
   int sdeb, sfin; /* Status at beginning and end */  
   int c,  h , cpt,l;    /*  printf("\n#Hessian matrix recomputed#\n");
   int ju,jl, mi;  
   int i1,j1, k1,k2,k3,jk,aa,bb, stepsize;    for (j=1;j<=npar;j++) {
   int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,**adl,*tab;      for (i=1;i<=npar;i++) x[i]=0;
        x[j]=1;
   int hstepm, nhstepm;      lubksb(a,npar,indx,x);
   double bage, fage, age, agelim, agebase;      for (i=1;i<=npar;i++){ 
   double ftolpl=FTOL;        y[i][j]=x[i];
   double **prlim;        printf("%.3e ",y[i][j]);
   double *severity;        fprintf(ficlog,"%.3e ",y[i][j]);
   double ***param; /* Matrix of parameters */      }
   double  *p;      printf("\n");
   double **matcov; /* Matrix of covariance */      fprintf(ficlog,"\n");
   double ***delti3; /* Scale */    }
   double *delti; /* Scale */    */
   double ***eij, ***vareij;  
   double **varpl; /* Variances of prevalence limits by age */    free_matrix(a,1,npar,1,npar);
   double *epj, vepp;    free_matrix(y,1,npar,1,npar);
   char version[80]="Imach version 62c, May 1999, INED-EUROREVES ";    free_vector(x,1,npar);
   char *alph[]={"a","a","b","c","d","e"}, str[4];    free_ivector(indx,1,npar);
     free_matrix(hess,1,npar,1,npar);
   char z[1]="c", occ;  
 #include <sys/time.h>  
 #include <time.h>  }
   char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];  
   /* long total_usecs;  /*************** hessian matrix ****************/
   struct timeval start_time, end_time;  double hessii( double x[], double delta, int theta, double delti[])
    {
   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */    int i;
     int l=1, lmax=20;
     double k1,k2;
   printf("\nIMACH, Version 0.64a");    double p2[NPARMAX+1];
   printf("\nEnter the parameter file name: ");    double res;
     double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;
 #ifdef windows    double fx;
   scanf("%s",pathtot);    int k=0,kmax=10;
   getcwd(pathcd, size);    double l1;
   /*cygwin_split_path(pathtot,path,optionfile);  
     printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/    fx=func(x);
   /* cutv(path,optionfile,pathtot,'\\');*/    for (i=1;i<=npar;i++) p2[i]=x[i];
     for(l=0 ; l <=lmax; l++){
 split(pathtot, path,optionfile);      l1=pow(10,l);
   chdir(path);      delts=delt;
   replace(pathc,path);      for(k=1 ; k <kmax; k=k+1){
 #endif        delt = delta*(l1*k);
 #ifdef unix        p2[theta]=x[theta] +delt;
   scanf("%s",optionfile);        k1=func(p2)-fx;
 #endif        p2[theta]=x[theta]-delt;
         k2=func(p2)-fx;
 /*-------- arguments in the command line --------*/        /*res= (k1-2.0*fx+k2)/delt/delt; */
         res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */
   strcpy(fileres,"r");        
   strcat(fileres, optionfile);  #ifdef DEBUG
         printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
   /*---------arguments file --------*/        fprintf(ficlog,"%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
   #endif
   if((ficpar=fopen(optionfile,"r"))==NULL)    {        /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */
     printf("Problem with optionfile %s\n",optionfile);        if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){
     goto end;          k=kmax;
   }        }
         else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */
   strcpy(filereso,"o");          k=kmax; l=lmax*10.;
   strcat(filereso,fileres);        }
   if((ficparo=fopen(filereso,"w"))==NULL) {        else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){ 
     printf("Problem with Output resultfile: %s\n", filereso);goto end;          delts=delt;
   }        }
       }
   /* Reads comments: lines beginning with '#' */    }
   while((c=getc(ficpar))=='#' && c!= EOF){    delti[theta]=delts;
     ungetc(c,ficpar);    return res; 
     fgets(line, MAXLINE, ficpar);    
     puts(line);  }
     fputs(line,ficparo);  
   }  double hessij( double x[], double delti[], int thetai,int thetaj)
   ungetc(c,ficpar);  {
     int i;
   fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncov, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);    int l=1, l1, lmax=20;
   printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate,ndeath, maxwav, mle, weightopt,model);    double k1,k2,k3,k4,res,fx;
   fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncov,nlstate,ndeath,maxwav, mle, weightopt,model);    double p2[NPARMAX+1];
     int k;
   covar=matrix(1,NCOVMAX,1,n);      
   if (strlen(model)<=1) cptcovn=0;    fx=func(x);
   else {    for (k=1; k<=2; k++) {
     j=0;      for (i=1;i<=npar;i++) p2[i]=x[i];
     j=nbocc(model,'+');      p2[thetai]=x[thetai]+delti[thetai]/k;
     cptcovn=j+1;      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
   }      k1=func(p2)-fx;
     
   ncovmodel=2+cptcovn;      p2[thetai]=x[thetai]+delti[thetai]/k;
   nvar=ncovmodel-1; /* Suppressing age as a basic covariate */      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
        k2=func(p2)-fx;
   /* Read guess parameters */    
   /* Reads comments: lines beginning with '#' */      p2[thetai]=x[thetai]-delti[thetai]/k;
   while((c=getc(ficpar))=='#' && c!= EOF){      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
     ungetc(c,ficpar);      k3=func(p2)-fx;
     fgets(line, MAXLINE, ficpar);    
     puts(line);      p2[thetai]=x[thetai]-delti[thetai]/k;
     fputs(line,ficparo);      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
   }      k4=func(p2)-fx;
   ungetc(c,ficpar);      res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */
    #ifdef DEBUG
   param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);      printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
     for(i=1; i <=nlstate; i++)      fprintf(ficlog,"%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
     for(j=1; j <=nlstate+ndeath-1; j++){  #endif
       fscanf(ficpar,"%1d%1d",&i1,&j1);    }
       fprintf(ficparo,"%1d%1d",i1,j1);    return res;
       printf("%1d%1d",i,j);  }
       for(k=1; k<=ncovmodel;k++){  
         fscanf(ficpar," %lf",&param[i][j][k]);  /************** Inverse of matrix **************/
         printf(" %lf",param[i][j][k]);  void ludcmp(double **a, int n, int *indx, double *d) 
         fprintf(ficparo," %lf",param[i][j][k]);  { 
       }    int i,imax,j,k; 
       fscanf(ficpar,"\n");    double big,dum,sum,temp; 
       printf("\n");    double *vv; 
       fprintf(ficparo,"\n");   
     }    vv=vector(1,n); 
      *d=1.0; 
   npar= (nlstate+ndeath-1)*nlstate*ncovmodel;    for (i=1;i<=n;i++) { 
   p=param[1][1];      big=0.0; 
        for (j=1;j<=n;j++) 
   /* Reads comments: lines beginning with '#' */        if ((temp=fabs(a[i][j])) > big) big=temp; 
   while((c=getc(ficpar))=='#' && c!= EOF){      if (big == 0.0) nrerror("Singular matrix in routine ludcmp"); 
     ungetc(c,ficpar);      vv[i]=1.0/big; 
     fgets(line, MAXLINE, ficpar);    } 
     puts(line);    for (j=1;j<=n;j++) { 
     fputs(line,ficparo);      for (i=1;i<j;i++) { 
   }        sum=a[i][j]; 
   ungetc(c,ficpar);        for (k=1;k<i;k++) sum -= a[i][k]*a[k][j]; 
         a[i][j]=sum; 
   delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);      } 
   delti=vector(1,npar); /* Scale of each paramater (output from hesscov) */      big=0.0; 
   for(i=1; i <=nlstate; i++){      for (i=j;i<=n;i++) { 
     for(j=1; j <=nlstate+ndeath-1; j++){        sum=a[i][j]; 
       fscanf(ficpar,"%1d%1d",&i1,&j1);        for (k=1;k<j;k++) 
       printf("%1d%1d",i,j);          sum -= a[i][k]*a[k][j]; 
       fprintf(ficparo,"%1d%1d",i1,j1);        a[i][j]=sum; 
       for(k=1; k<=ncovmodel;k++){        if ( (dum=vv[i]*fabs(sum)) >= big) { 
         fscanf(ficpar,"%le",&delti3[i][j][k]);          big=dum; 
         printf(" %le",delti3[i][j][k]);          imax=i; 
         fprintf(ficparo," %le",delti3[i][j][k]);        } 
       }      } 
       fscanf(ficpar,"\n");      if (j != imax) { 
       printf("\n");        for (k=1;k<=n;k++) { 
       fprintf(ficparo,"\n");          dum=a[imax][k]; 
     }          a[imax][k]=a[j][k]; 
   }          a[j][k]=dum; 
   delti=delti3[1][1];        } 
          *d = -(*d); 
   /* Reads comments: lines beginning with '#' */        vv[imax]=vv[j]; 
   while((c=getc(ficpar))=='#' && c!= EOF){      } 
     ungetc(c,ficpar);      indx[j]=imax; 
     fgets(line, MAXLINE, ficpar);      if (a[j][j] == 0.0) a[j][j]=TINY; 
     puts(line);      if (j != n) { 
     fputs(line,ficparo);        dum=1.0/(a[j][j]); 
   }        for (i=j+1;i<=n;i++) a[i][j] *= dum; 
   ungetc(c,ficpar);      } 
      } 
   matcov=matrix(1,npar,1,npar);    free_vector(vv,1,n);  /* Doesn't work */
   for(i=1; i <=npar; i++){  ;
     fscanf(ficpar,"%s",&str);  } 
     printf("%s",str);  
     fprintf(ficparo,"%s",str);  void lubksb(double **a, int n, int *indx, double b[]) 
     for(j=1; j <=i; j++){  { 
       fscanf(ficpar," %le",&matcov[i][j]);    int i,ii=0,ip,j; 
       printf(" %.5le",matcov[i][j]);    double sum; 
       fprintf(ficparo," %.5le",matcov[i][j]);   
     }    for (i=1;i<=n;i++) { 
     fscanf(ficpar,"\n");      ip=indx[i]; 
     printf("\n");      sum=b[ip]; 
     fprintf(ficparo,"\n");      b[ip]=b[i]; 
   }      if (ii) 
   for(i=1; i <=npar; i++)        for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j]; 
     for(j=i+1;j<=npar;j++)      else if (sum) ii=i; 
       matcov[i][j]=matcov[j][i];      b[i]=sum; 
        } 
   printf("\n");    for (i=n;i>=1;i--) { 
       sum=b[i]; 
       for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j]; 
    if(mle==1){      b[i]=sum/a[i][i]; 
     /*-------- data file ----------*/    } 
     if((ficres =fopen(fileres,"w"))==NULL) {  } 
       printf("Problem with resultfile: %s\n", fileres);goto end;  
     }  /************ Frequencies ********************/
     fprintf(ficres,"#%s\n",version);  void  freqsummary(char fileres[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, int *Tvaraff, int **nbcode, int *ncodemax,double **mint,double **anint)
      {  /* Some frequencies */
     if((fic=fopen(datafile,"r"))==NULL)    {    
       printf("Problem with datafile: %s\n", datafile);goto end;    int i, m, jk, k1,i1, j1, bool, z1,z2,j;
     }    int first;
     double ***freq; /* Frequencies */
     n= lastobs;    double *pp, **prop;
     severity = vector(1,maxwav);    double pos,posprop, k2, dateintsum=0,k2cpt=0;
     outcome=imatrix(1,maxwav+1,1,n);    FILE *ficresp;
     num=ivector(1,n);    char fileresp[FILENAMELENGTH];
     moisnais=vector(1,n);    
     annais=vector(1,n);    pp=vector(1,nlstate);
     moisdc=vector(1,n);    prop=matrix(1,nlstate,iagemin,iagemax+3);
     andc=vector(1,n);    strcpy(fileresp,"p");
     agedc=vector(1,n);    strcat(fileresp,fileres);
     cod=ivector(1,n);    if((ficresp=fopen(fileresp,"w"))==NULL) {
     weight=vector(1,n);      printf("Problem with prevalence resultfile: %s\n", fileresp);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */      fprintf(ficlog,"Problem with prevalence resultfile: %s\n", fileresp);
     mint=matrix(1,maxwav,1,n);      exit(0);
     anint=matrix(1,maxwav,1,n);    }
     s=imatrix(1,maxwav+1,1,n);    freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);
     adl=imatrix(1,maxwav+1,1,n);        j1=0;
     tab=ivector(1,NCOVMAX);    
     ncodemax=ivector(1,8);    j=cptcoveff;
     if (cptcovn<1) {j=1;ncodemax[1]=1;}
     i=1;  
     while (fgets(line, MAXLINE, fic) != NULL)    {    first=1;
       if ((i >= firstobs) && (i <=lastobs)) {  
            for(k1=1; k1<=j;k1++){
         for (j=maxwav;j>=1;j--){      for(i1=1; i1<=ncodemax[k1];i1++){
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb);        j1++;
           strcpy(line,stra);        /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);          scanf("%d", i);*/
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);        for (i=-1; i<=nlstate+ndeath; i++)  
         }          for (jk=-1; jk<=nlstate+ndeath; jk++)  
                    for(m=iagemin; m <= iagemax+3; m++)
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);              freq[i][jk][m]=0;
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);  
       for (i=1; i<=nlstate; i++)  
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);        for(m=iagemin; m <= iagemax+3; m++)
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);          prop[i][m]=0;
         
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);        dateintsum=0;
         for (j=ncov;j>=1;j--){        k2cpt=0;
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);        for (i=1; i<=imx; i++) {
         }          bool=1;
         num[i]=atol(stra);          if  (cptcovn>0) {
             for (z1=1; z1<=cptcoveff; z1++) 
         /*printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));*/              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
                 bool=0;
         i=i+1;          }
       }          if (bool==1){
     }            for(m=firstpass; m<=lastpass; m++){
               k2=anint[m][i]+(mint[m][i]/12.);
     /*scanf("%d",i);*/              /*if ((k2>=dateprev1) && (k2<=dateprev2)) {*/
   imx=i-1; /* Number of individuals */                if(agev[m][i]==0) agev[m][i]=iagemax+1;
                 if(agev[m][i]==1) agev[m][i]=iagemax+2;
   /* Calculation of the number of parameter from char model*/                if (s[m][i]>0 && s[m][i]<=nlstate) prop[s[m][i]][(int)agev[m][i]] += weight[i];
   Tvar=ivector(1,8);                    if (m<lastpass) {
                      freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];
   if (strlen(model) >1){                  freq[s[m][i]][s[m+1][i]][iagemax+3] += weight[i];
     j=0;                }
     j=nbocc(model,'+');                
     cptcovn=j+1;                if ((agev[m][i]>1) && (agev[m][i]< (iagemax+3))) {
                      dateintsum=dateintsum+k2;
     strcpy(modelsav,model);                  k2cpt++;
     if (j==0) {                }
       cutv(stra,strb,modelsav,'V'); Tvar[1]=atoi(strb);                /*}*/
     }            }
     else {          }
       for(i=j; i>=1;i--){        }
         cutv(stra,strb,modelsav,'+');         
         if (strchr(strb,'*')) {        /*      fprintf(ficresp, "#Count between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
           cutv(strd,strc,strb,'*');  
           cutv(strb,stre,strc,'V');Tvar[i+1]=ncov+1;        if  (cptcovn>0) {
           cutv(strb,strc,strd,'V');          fprintf(ficresp, "\n#********** Variable "); 
           for (k=1; k<=lastobs;k++)          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
             covar[ncov+1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];          fprintf(ficresp, "**********\n#");
         }        }
         else {cutv(strd,strc,strb,'V');        for(i=1; i<=nlstate;i++) 
         Tvar[i+1]=atoi(strc);          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);
         }        fprintf(ficresp, "\n");
         strcpy(modelsav,stra);          
       }        for(i=iagemin; i <= iagemax+3; i++){
       cutv(strd,strc,stra,'V');          if(i==iagemax+3){
       Tvar[1]=atoi(strc);            fprintf(ficlog,"Total");
     }          }else{
   }            if(first==1){
   /*printf("tvar=%d ",Tvar[1]);              first=0;
   scanf("%d ",i);*/              printf("See log file for details...\n");
     fclose(fic);            }
             fprintf(ficlog,"Age %d", i);
     if (weightopt != 1) { /* Maximisation without weights*/          }
       for(i=1;i<=n;i++) weight[i]=1.0;          for(jk=1; jk <=nlstate ; jk++){
     }            for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)
     /*-calculation of age at interview from date of interview and age at death -*/              pp[jk] += freq[jk][m][i]; 
     agev=matrix(1,maxwav,1,imx);          }
              for(jk=1; jk <=nlstate ; jk++){
     for (i=1; i<=imx; i++)  {            for(m=-1, pos=0; m <=0 ; m++)
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);              pos += freq[jk][m][i];
       for(m=1; (m<= maxwav); m++){            if(pp[jk]>=1.e-10){
         if(s[m][i] >0){              if(first==1){
           if (s[m][i] == nlstate+1) {              printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
             if(agedc[i]>0)              }
               if(moisdc[i]!=99 && andc[i]!=9999)              fprintf(ficlog," %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
               agev[m][i]=agedc[i];            }else{
             else{              if(first==1)
               printf("Warning negative age at death: %d line:%d\n",num[i],i);                printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
               agev[m][i]=-1;              fprintf(ficlog," %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
             }            }
           }          }
           else if(s[m][i] !=9){ /* Should no more exist */  
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);          for(jk=1; jk <=nlstate ; jk++){
             if(mint[m][i]==99 || anint[m][i]==9999)            for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)
               agev[m][i]=1;              pp[jk] += freq[jk][m][i];
             else if(agev[m][i] <agemin){          }       
               agemin=agev[m][i];          for(jk=1,pos=0,posprop=0; jk <=nlstate ; jk++){
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/            pos += pp[jk];
             }            posprop += prop[jk][i];
             else if(agev[m][i] >agemax){          }
               agemax=agev[m][i];          for(jk=1; jk <=nlstate ; jk++){
              /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/            if(pos>=1.e-5){
             }              if(first==1)
             /*agev[m][i]=anint[m][i]-annais[i];*/                printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
             /*   agev[m][i] = age[i]+2*m;*/              fprintf(ficlog," %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
           }            }else{
           else { /* =9 */              if(first==1)
             agev[m][i]=1;                printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
             s[m][i]=-1;              fprintf(ficlog," %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
           }            }
         }            if( i <= iagemax){
         else /*= 0 Unknown */              if(pos>=1.e-5){
           agev[m][i]=1;                fprintf(ficresp," %d %.5f %.0f %.0f",i,prop[jk][i]/posprop, prop[jk][i],posprop);
       }                /*probs[i][jk][j1]= pp[jk]/pos;*/
                    /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/
     }              }
     for (i=1; i<=imx; i++)  {              else
       for(m=1; (m<= maxwav); m++){                fprintf(ficresp," %d NaNq %.0f %.0f",i,prop[jk][i],posprop);
         if (s[m][i] > (nlstate+ndeath)) {            }
           printf("Error: Wrong value in nlstate or ndeath\n");            }
           goto end;          
         }          for(jk=-1; jk <=nlstate+ndeath; jk++)
       }            for(m=-1; m <=nlstate+ndeath; m++)
     }              if(freq[jk][m][i] !=0 ) {
               if(first==1)
 printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);                printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);
                 fprintf(ficlog," %d%d=%.0f",jk,m,freq[jk][m][i]);
     free_vector(severity,1,maxwav);              }
     free_imatrix(outcome,1,maxwav+1,1,n);          if(i <= iagemax)
     free_vector(moisnais,1,n);            fprintf(ficresp,"\n");
     free_vector(annais,1,n);          if(first==1)
     free_matrix(mint,1,maxwav,1,n);            printf("Others in log...\n");
     free_matrix(anint,1,maxwav,1,n);          fprintf(ficlog,"\n");
     free_vector(moisdc,1,n);        }
     free_vector(andc,1,n);      }
     }
        dateintmean=dateintsum/k2cpt; 
     wav=ivector(1,imx);   
     dh=imatrix(1,lastpass-firstpass+1,1,imx);    fclose(ficresp);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);    free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);
        free_vector(pp,1,nlstate);
     /* Concatenates waves */    free_matrix(prop,1,nlstate,iagemin, iagemax+3);
       concatwav(wav, dh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);    /* End of Freq */
   }
   
 Tcode=ivector(1,100);  /************ Prevalence ********************/
    nbcode=imatrix(1,nvar,1,8);    void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass)
    ncodemax[1]=1;  {  
    if (cptcovn > 0) tricode(Tvar,nbcode,imx);    /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people
         in each health status at the date of interview (if between dateprev1 and dateprev2).
    codtab=imatrix(1,100,1,10);       We still use firstpass and lastpass as another selection.
    h=0;    */
    m=pow(2,cptcovn);   
      int i, m, jk, k1, i1, j1, bool, z1,z2,j;
    for(k=1;k<=cptcovn; k++){    double ***freq; /* Frequencies */
      for(i=1; i <=(m/pow(2,k));i++){    double *pp, **prop;
        for(j=1; j <= ncodemax[k]; j++){    double pos,posprop; 
          for(cpt=1; cpt <=(m/pow(2,cptcovn+1-k)); cpt++){    double  y2; /* in fractional years */
            h++;    int iagemin, iagemax;
            if (h>m) h=1;codtab[h][k]=j;  
          }    iagemin= (int) agemin;
        }    iagemax= (int) agemax;
      }    /*pp=vector(1,nlstate);*/
    }    prop=matrix(1,nlstate,iagemin,iagemax+3); 
     /*  freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);*/
    /*for(i=1; i <=m ;i++){    j1=0;
      for(k=1; k <=cptcovn; k++){    
        printf("i=%d k=%d %d ",i,k,codtab[i][k]);    j=cptcoveff;
      }    if (cptcovn<1) {j=1;ncodemax[1]=1;}
      printf("\n");    
    }*/    for(k1=1; k1<=j;k1++){
    /*scanf("%d",i);*/      for(i1=1; i1<=ncodemax[k1];i1++){
            j1++;
    /* Calculates basic frequencies. Computes observed prevalence at single age        
        and prints on file fileres'p'. */        for (i=1; i<=nlstate; i++)  
   freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax);          for(m=iagemin; m <= iagemax+3; m++)
             prop[i][m]=0.0;
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */       
     oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */        for (i=1; i<=imx; i++) { /* Each individual */
     newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */          bool=1;
     savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */          if  (cptcovn>0) {
     oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */            for (z1=1; z1<=cptcoveff; z1++) 
                  if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
     /* For Powell, parameters are in a vector p[] starting at p[1]                bool=0;
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */          } 
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */          if (bool==1) { 
                for(m=firstpass; m<=lastpass; m++){/* Other selection (we can limit to certain interviews*/
     mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);              y2=anint[m][i]+(mint[m][i]/12.); /* Fractional date in year */
               if ((y2>=dateprev1) && (y2<=dateprev2)) { /* Here is the main selection (fractional years) */
                    if(agev[m][i]==0) agev[m][i]=iagemax+1;
     /*--------- results files --------------*/                if(agev[m][i]==1) agev[m][i]=iagemax+2;
     fprintf(ficres,"\ntitle=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate, ndeath, maxwav, mle,weightopt,model);                if((int)agev[m][i] <iagemin || (int)agev[m][i] >iagemax+3) printf("Error on individual =%d agev[m][i]=%f m=%d\n",i, agev[m][i],m); 
                    if (s[m][i]>0 && s[m][i]<=nlstate) { 
    jk=1;                  /*if(i>4620) printf(" i=%d m=%d s[m][i]=%d (int)agev[m][i]=%d weight[i]=%f prop=%f\n",i,m,s[m][i],(int)agev[m][m],weight[i],prop[s[m][i]][(int)agev[m][i]]);*/
    fprintf(ficres,"# Parameters\n");                  prop[s[m][i]][(int)agev[m][i]] += weight[i];
    printf("# Parameters\n");                  prop[s[m][i]][iagemax+3] += weight[i]; 
    for(i=1,jk=1; i <=nlstate; i++){                } 
      for(k=1; k <=(nlstate+ndeath); k++){              }
        if (k != i)            } /* end selection of waves */
          {          }
            printf("%d%d ",i,k);        }
            fprintf(ficres,"%1d%1d ",i,k);        for(i=iagemin; i <= iagemax+3; i++){  
            for(j=1; j <=ncovmodel; j++){          
              printf("%f ",p[jk]);          for(jk=1,posprop=0; jk <=nlstate ; jk++) { 
              fprintf(ficres,"%f ",p[jk]);            posprop += prop[jk][i]; 
              jk++;          } 
            }  
            printf("\n");          for(jk=1; jk <=nlstate ; jk++){     
            fprintf(ficres,"\n");            if( i <=  iagemax){ 
          }              if(posprop>=1.e-5){ 
      }                probs[i][jk][j1]= prop[jk][i]/posprop;
    }              } 
             } 
     /* Computing hessian and covariance matrix */          }/* end jk */ 
     ftolhess=ftol; /* Usually correct */        }/* end i */ 
     hesscov(matcov, p, npar, delti, ftolhess, func);      } /* end i1 */
     fprintf(ficres,"# Scales\n");    } /* end k1 */
     printf("# Scales\n");    
      for(i=1,jk=1; i <=nlstate; i++){    /*  free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);*/
       for(j=1; j <=nlstate+ndeath; j++){    /*free_vector(pp,1,nlstate);*/
         if (j!=i) {    free_matrix(prop,1,nlstate, iagemin,iagemax+3);
           fprintf(ficres,"%1d%1d",i,j);  }  /* End of prevalence */
           printf("%1d%1d",i,j);  
           for(k=1; k<=ncovmodel;k++){  /************* Waves Concatenation ***************/
             printf(" %.5e",delti[jk]);  
             fprintf(ficres," %.5e",delti[jk]);  void  concatwav(int wav[], int **dh, int **bh,  int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)
             jk++;  {
           }    /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.
           printf("\n");       Death is a valid wave (if date is known).
           fprintf(ficres,"\n");       mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i
         }       dh[m][i] or dh[mw[mi][i]][i] is the delay between two effective waves m=mw[mi][i]
       }       and mw[mi+1][i]. dh depends on stepm.
       }       */
      
     k=1;    int i, mi, m;
     fprintf(ficres,"# Covariance\n");    /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;
     printf("# Covariance\n");       double sum=0., jmean=0.;*/
     for(i=1;i<=npar;i++){    int first;
       /*  if (k>nlstate) k=1;    int j, k=0,jk, ju, jl;
       i1=(i-1)/(ncovmodel*nlstate)+1;    double sum=0.;
       fprintf(ficres,"%s%d%d",alph[k],i1,tab[i]);    first=0;
       printf("%s%d%d",alph[k],i1,tab[i]);*/    jmin=1e+5;
       fprintf(ficres,"%3d",i);    jmax=-1;
       printf("%3d",i);    jmean=0.;
       for(j=1; j<=i;j++){    for(i=1; i<=imx; i++){
         fprintf(ficres," %.5e",matcov[i][j]);      mi=0;
         printf(" %.5e",matcov[i][j]);      m=firstpass;
       }      while(s[m][i] <= nlstate){
       fprintf(ficres,"\n");        if(s[m][i]>=1)
       printf("\n");          mw[++mi][i]=m;
       k++;        if(m >=lastpass)
     }          break;
            else
     while((c=getc(ficpar))=='#' && c!= EOF){          m++;
       ungetc(c,ficpar);      }/* end while */
       fgets(line, MAXLINE, ficpar);      if (s[m][i] > nlstate){
       puts(line);        mi++;     /* Death is another wave */
       fputs(line,ficparo);        /* if(mi==0)  never been interviewed correctly before death */
     }           /* Only death is a correct wave */
     ungetc(c,ficpar);        mw[mi][i]=m;
        }
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);  
          wav[i]=mi;
     if (fage <= 2) {      if(mi==0){
       bage = agemin;        nbwarn++;
       fage = agemax;        if(first==0){
     }          printf("Warning! None valid information for:%ld line=%d (skipped) and may be others, see log file\n",num[i],i);
           first=1;
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");        }
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);        if(first==1){
 /*------------ gnuplot -------------*/          fprintf(ficlog,"Warning! None valid information for:%ld line=%d (skipped)\n",num[i],i);
 chdir(pathcd);        }
   if((ficgp=fopen("graph.plt","w"))==NULL) {      } /* end mi==0 */
     printf("Problem with file graph.gp");goto end;    } /* End individuals */
   }  
 #ifdef windows    for(i=1; i<=imx; i++){
   fprintf(ficgp,"cd \"%s\" \n",pathc);      for(mi=1; mi<wav[i];mi++){
 #endif        if (stepm <=0)
 m=pow(2,cptcovn);          dh[mi][i]=1;
          else{
  /* 1eme*/          if (s[mw[mi+1][i]][i] > nlstate) { /* A death */
   for (cpt=1; cpt<= nlstate ; cpt ++) {            if (agedc[i] < 2*AGESUP) {
    for (k1=1; k1<= m ; k1 ++) {              j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12); 
               if(j==0) j=1;  /* Survives at least one month after exam */
 #ifdef windows              else if(j<0){
     fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"vpl%s\" every :::%d::%d u 1:2 \"\%%lf",agemin,fage,fileres,k1-1,k1-1);                nberr++;
 #endif                printf("Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
 #ifdef unix                j=1; /* Temporary Dangerous patch */
 fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nplot [%.f:%.f] \"vpl%s\" u 1:2 \"\%%lf",agemin,fage,fileres);                printf("   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview.\n  You MUST fix the contradiction between dates.\n",stepm);
 #endif                fprintf(ficlog,"Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
                 fprintf(ficlog,"   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview.\n  You MUST fix the contradiction between dates.\n",stepm);
 for (i=1; i<= nlstate ; i ++) {              }
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");              k=k+1;
   else fprintf(ficgp," \%%*lf (\%%*lf)");              if (j >= jmax) jmax=j;
 }              if (j <= jmin) jmin=j;
     fprintf(ficgp,"\" t\"Stationary prevalence\" w l 0,\"vpl%s\" every :::%d::%d u 1:($2+2*$3) \"\%%lf",fileres,k1-1,k1-1);              sum=sum+j;
     for (i=1; i<= nlstate ; i ++) {              /*if (j<0) printf("j=%d num=%d \n",j,i);*/
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");              /*    printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
   else fprintf(ficgp," \%%*lf (\%%*lf)");            }
 }          }
   fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"vpl%s\" every :::%d::%d u 1:($2-2*$3) \"\%%lf",fileres,k1-1,k1-1);          else{
      for (i=1; i<= nlstate ; i ++) {            j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");            /*      printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
   else fprintf(ficgp," \%%*lf (\%%*lf)");            k=k+1;
 }              if (j >= jmax) jmax=j;
      fprintf(ficgp,"\" t\"\" w l 1,\"p%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",fileres,k1-1,k1-1,2+4*(cpt-1));            else if (j <= jmin)jmin=j;
 #ifdef unix            /*        if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */
 fprintf(ficgp,"\nset ter gif small size 400,300");            /*printf("%d %lf %d %d %d\n", i,agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);*/
 #endif            if(j<0){
 fprintf(ficgp,"\nset out \"v%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);              nberr++;
    }              printf("Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   }              fprintf(ficlog,"Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   /*2 eme*/            }
             sum=sum+j;
   for (k1=1; k1<= m ; k1 ++) {          }
     fprintf(ficgp,"set ylabel \"Years\" \nset ter gif small size 400,300\nplot [%.f:%.f] ",agemin,fage);          jk= j/stepm;
              jl= j -jk*stepm;
     for (i=1; i<= nlstate+1 ; i ++) {          ju= j -(jk+1)*stepm;
       k=2*i;          if(mle <=1){ /* only if we use a the linear-interpoloation pseudo-likelihood */
       fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:2 \"\%%lf",fileres,k1-1,k1-1);            if(jl==0){
       for (j=1; j<= nlstate+1 ; j ++) {              dh[mi][i]=jk;
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");              bh[mi][i]=0;
   else fprintf(ficgp," \%%*lf (\%%*lf)");            }else{ /* We want a negative bias in order to only have interpolation ie
 }                      * at the price of an extra matrix product in likelihood */
       if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");              dh[mi][i]=jk+1;
       else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);              bh[mi][i]=ju;
     fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",fileres,k1-1,k1-1);            }
       for (j=1; j<= nlstate+1 ; j ++) {          }else{
         if (j==i) fprintf(ficgp," \%%lf (\%%lf)");            if(jl <= -ju){
         else fprintf(ficgp," \%%*lf (\%%*lf)");              dh[mi][i]=jk;
 }                bh[mi][i]=jl;       /* bias is positive if real duration
       fprintf(ficgp,"\" t\"\" w l 0,");                                   * is higher than the multiple of stepm and negative otherwise.
      fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",fileres,k1-1,k1-1);                                   */
       for (j=1; j<= nlstate+1 ; j ++) {            }
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");            else{
   else fprintf(ficgp," \%%*lf (\%%*lf)");              dh[mi][i]=jk+1;
 }                bh[mi][i]=ju;
       if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");            }
       else fprintf(ficgp,"\" t\"\" w l 0,");            if(dh[mi][i]==0){
     }              dh[mi][i]=1; /* At least one step */
     fprintf(ficgp,"\nset out \"e%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),k1);              bh[mi][i]=ju; /* At least one step */
   }              /*  printf(" bh=%d ju=%d jl=%d dh=%d jk=%d stepm=%d %d\n",bh[mi][i],ju,jl,dh[mi][i],jk,stepm,i);*/
              }
   /*3eme*/          } /* end if mle */
         }
   for (k1=1; k1<= m ; k1 ++) {      } /* end wave */
     for (cpt=1; cpt<= nlstate ; cpt ++) {    }
       k=2+nlstate*(cpt-1);    jmean=sum/k;
       fprintf(ficgp,"set ter gif small size 400,300\nplot [%.f:%.f] \"e%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",agemin,fage,fileres,k1-1,k1-1,k,cpt);    printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);
       for (i=1; i< nlstate ; i ++) {    fprintf(ficlog,"Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,jmean);
         fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",fileres,k1-1,k1-1,k+i,cpt,i+1);   }
       }  
       fprintf(ficgp,"\nset out \"exp%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);  /*********** Tricode ****************************/
     }  void tricode(int *Tvar, int **nbcode, int imx)
   }  {
      
   /* CV preval stat */    int Ndum[20],ij=1, k, j, i, maxncov=19;
   for (k1=1; k1<= m ; k1 ++) {    int cptcode=0;
     for (cpt=1; cpt<nlstate ; cpt ++) {    cptcoveff=0; 
       k=3;   
       fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",agemin,agemax,fileres,k1,k+cpt+1,k+1);    for (k=0; k<maxncov; k++) Ndum[k]=0;
       for (i=1; i< nlstate ; i ++)    for (k=1; k<=7; k++) ncodemax[k]=0;
         fprintf(ficgp,"+$%d",k+i+1);  
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);    for (j=1; j<=(cptcovn+2*cptcovprod); j++) {
            for (i=1; i<=imx; i++) { /*reads the data file to get the maximum 
       l=3+(nlstate+ndeath)*cpt;                                 modality*/ 
       fprintf(ficgp,",\"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",fileres,k1,l+cpt+1,l+1);        ij=(int)(covar[Tvar[j]][i]); /* ij is the modality of this individual*/
       for (i=1; i< nlstate ; i ++) {        Ndum[ij]++; /*store the modality */
         l=3+(nlstate+ndeath)*cpt;        /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/
         fprintf(ficgp,"+$%d",l+i+1);        if (ij > cptcode) cptcode=ij; /* getting the maximum of covariable 
       }                                         Tvar[j]. If V=sex and male is 0 and 
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);                                           female is 1, then  cptcode=1.*/
       fprintf(ficgp,"set out \"p%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);      }
     }  
   }      for (i=0; i<=cptcode; i++) {
         if(Ndum[i]!=0) ncodemax[j]++; /* Nomber of modalities of the j th covariates. In fact ncodemax[j]=2 (dichotom. variables) but it can be more */
   /* proba elementaires */      }
    for(i=1,jk=1; i <=nlstate; i++){  
     for(k=1; k <=(nlstate+ndeath); k++){      ij=1; 
       if (k != i) {      for (i=1; i<=ncodemax[j]; i++) {
         for(j=1; j <=ncovmodel; j++){        for (k=0; k<= maxncov; k++) {
           /*fprintf(ficgp,"%s%1d%1d=%f ",alph[j],i,k,p[jk]);*/          if (Ndum[k] != 0) {
           /*fprintf(ficgp,"%s",alph[1]);*/            nbcode[Tvar[j]][ij]=k; 
           fprintf(ficgp,"p%d=%f ",jk,p[jk]);            /* store the modality in an array. k is a modality. If we have model=V1+V1*sex then: nbcode[1][1]=0 ; nbcode[1][2]=1; nbcode[2][1]=0 ; nbcode[2][2]=1; */
           jk++;            
           fprintf(ficgp,"\n");            ij++;
         }          }
       }          if (ij > ncodemax[j]) break; 
     }        }  
     }      } 
     }  
   for(jk=1; jk <=m; jk++) {  
   fprintf(ficgp,"\nset ter gif small size 400,300\nset log y\nplot  [%.f:%.f] ",agemin,agemax);   for (k=0; k< maxncov; k++) Ndum[k]=0;
    i=1;  
    for(k2=1; k2<=nlstate; k2++) {   for (i=1; i<=ncovmodel-2; i++) { 
      k3=i;     /* Listing of all covariables in staement model to see if some covariates appear twice. For example, V1 appears twice in V1+V1*V2.*/
      for(k=1; k<=(nlstate+ndeath); k++) {     ij=Tvar[i];
        if (k != k2){     Ndum[ij]++;
         fprintf(ficgp," exp(p%d+p%d*x",i,i+1);   }
   
         for(j=3; j <=ncovmodel; j++)   ij=1;
           fprintf(ficgp,"+p%d*%d",k2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);   for (i=1; i<= maxncov; i++) {
         fprintf(ficgp,")/(1");     if((Ndum[i]!=0) && (i<=ncovcol)){
        Tvaraff[ij]=i; /*For printing */
         for(k1=1; k1 <=nlstate+1; k1=k1+2){         ij++;
             fprintf(ficgp,"+exp(p%d+p%d*x",k1+k3-1,k1+k3);     }
    }
             for(j=3; j <=ncovmodel; j++)   
               fprintf(ficgp,"+p%d*%d",k2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);   cptcoveff=ij-1; /*Number of simple covariates*/
             fprintf(ficgp,")");  }
         }  
         fprintf(ficgp,") t \"p%d%d\" ", k2,k);  /*********** Health Expectancies ****************/
         if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");  
     i=i+ncovmodel;  void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij, int estepm,double delti[],double **matcov )
        }  
      }  {
    }    /* Health expectancies */
   fprintf(ficgp,"\nset out \"pe%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),jk);    int i, j, nhstepm, hstepm, h, nstepm, k, cptj;
    }    double age, agelim, hf;
        double ***p3mat,***varhe;
   fclose(ficgp);    double **dnewm,**doldm;
        double *xp;
 chdir(path);    double **gp, **gm;
     free_matrix(agev,1,maxwav,1,imx);    double ***gradg, ***trgradg;
     free_ivector(wav,1,imx);    int theta;
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);  
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);    varhe=ma3x(1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int) fage);
        xp=vector(1,npar);
     free_imatrix(s,1,maxwav+1,1,n);    dnewm=matrix(1,nlstate*nlstate,1,npar);
        doldm=matrix(1,nlstate*nlstate,1,nlstate*nlstate);
        
     free_ivector(num,1,n);    fprintf(ficreseij,"# Health expectancies\n");
     free_vector(agedc,1,n);    fprintf(ficreseij,"# Age");
     free_vector(weight,1,n);    for(i=1; i<=nlstate;i++)
     /*free_matrix(covar,1,NCOVMAX,1,n);*/      for(j=1; j<=nlstate;j++)
     fclose(ficparo);        fprintf(ficreseij," %1d-%1d (SE)",i,j);
     fclose(ficres);    fprintf(ficreseij,"\n");
    }  
        if(estepm < stepm){
    /*________fin mle=1_________*/      printf ("Problem %d lower than %d\n",estepm, stepm);
        }
     else  hstepm=estepm;   
      /* We compute the life expectancy from trapezoids spaced every estepm months
     /* No more information from the sample is required now */     * This is mainly to measure the difference between two models: for example
   /* Reads comments: lines beginning with '#' */     * if stepm=24 months pijx are given only every 2 years and by summing them
   while((c=getc(ficpar))=='#' && c!= EOF){     * we are calculating an estimate of the Life Expectancy assuming a linear 
     ungetc(c,ficpar);     * progression in between and thus overestimating or underestimating according
     fgets(line, MAXLINE, ficpar);     * to the curvature of the survival function. If, for the same date, we 
     puts(line);     * estimate the model with stepm=1 month, we can keep estepm to 24 months
     fputs(line,ficparo);     * to compare the new estimate of Life expectancy with the same linear 
   }     * hypothesis. A more precise result, taking into account a more precise
   ungetc(c,ficpar);     * curvature will be obtained if estepm is as small as stepm. */
    
   fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);    /* For example we decided to compute the life expectancy with the smallest unit */
   printf("agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax, bage, fage);    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
   fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);       nhstepm is the number of hstepm from age to agelim 
 /*--------- index.htm --------*/       nstepm is the number of stepm from age to agelin. 
        Look at hpijx to understand the reason of that which relies in memory size
   if((fichtm=fopen("index.htm","w"))==NULL)    {       and note for a fixed period like estepm months */
     printf("Problem with index.htm \n");goto end;    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
   }       survival function given by stepm (the optimization length). Unfortunately it
        means that if the survival funtion is printed only each two years of age and if
  fprintf(fichtm,"<body><ul> Imach, Version 0.64a<hr> <li>Outputs files<br><br>\n       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
         - Observed prevalence in each state: <a href=\"p%s\">p%s</a> <br>\n       results. So we changed our mind and took the option of the best precision.
 - Estimated parameters and the covariance matrix: <a href=\"%s\">%s</a> <br>    */
         - Stationary prevalence in each state: <a href=\"pl%s\">pl%s</a> <br>    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
         - Transition probabilities: <a href=\"pij%s\">pij%s</a><br>  
         - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>    agelim=AGESUP;
         - Life expectancies by age and initial health status: <a href=\"e%s\">e%s</a> <br>    for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
         - Variances of life expectancies by age and initial health status: <a href=\"v%s\">v%s</a><br>      /* nhstepm age range expressed in number of stepm */
         - Health expectancies with their variances: <a href=\"t%s\">t%s</a> <br>      nstepm=(int) rint((agelim-age)*YEARM/stepm); 
         - Standard deviation of stationary prevalences: <a href=\"vpl%s\">vpl%s</a> <br><br>",fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres);      /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
       /* if (stepm >= YEARM) hstepm=1;*/
  fprintf(fichtm," <li>Graphs</li>\n<p>");      nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
  m=cptcovn;      gradg=ma3x(0,nhstepm,1,npar,1,nlstate*nlstate);
  if (cptcovn < 1) {m=1;ncodemax[1]=1;}      gp=matrix(0,nhstepm,1,nlstate*nlstate);
       gm=matrix(0,nhstepm,1,nlstate*nlstate);
  j1=0;  
  for(k1=1; k1<=m;k1++){      /* Computed by stepm unit matrices, product of hstepm matrices, stored
    for(i1=1; i1<=ncodemax[k1];i1++){         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
        j1++;      hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);  
        if (cptcovn > 0) {   
          fprintf(fichtm,"<hr>************ Results for covariates");  
          for (cpt=1; cpt<=cptcovn;cpt++)      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
            fprintf(fichtm," V%d=%d ",Tvar[cpt],nbcode[Tvar[cpt]][codtab[j1][cpt]]);  
          fprintf(fichtm," ************\n<hr>");      /* Computing  Variances of health expectancies */
        }  
        fprintf(fichtm,"<br>- Probabilities: pe%s%d.gif<br>       for(theta=1; theta <=npar; theta++){
 <img src=\"pe%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);            for(i=1; i<=npar; i++){ 
        for(cpt=1; cpt<nlstate;cpt++){          xp[i] = x[i] + (i==theta ?delti[theta]:0);
          fprintf(fichtm,"<br>- Prevalence of disability : p%s%d%d.gif<br>        }
 <img src=\"p%s%d%d.gif\">",strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
        }    
     for(cpt=1; cpt<=nlstate;cpt++) {        cptj=0;
        fprintf(fichtm,"<br>- Observed and stationary prevalence (with confident        for(j=1; j<= nlstate; j++){
 interval) in state (%d): v%s%d%d.gif <br>          for(i=1; i<=nlstate; i++){
 <img src=\"v%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);              cptj=cptj+1;
      }            for(h=0, gp[h][cptj]=0.; h<=nhstepm-1; h++){
      for(cpt=1; cpt<=nlstate;cpt++) {              gp[h][cptj] = (p3mat[i][j][h]+p3mat[i][j][h+1])/2.;
         fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): exp%s%d%d.gif <br>            }
 <img src=\"exp%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);          }
      }        }
      fprintf(fichtm,"\n<br>- Total life expectancy by age and       
 health expectancies in states (1) and (2): e%s%d.gif<br>       
 <img src=\"e%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);        for(i=1; i<=npar; i++) 
 fprintf(fichtm,"\n</body>");          xp[i] = x[i] - (i==theta ?delti[theta]:0);
    }        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
  }        
 fclose(fichtm);        cptj=0;
         for(j=1; j<= nlstate; j++){
   /*--------------- Prevalence limit --------------*/          for(i=1;i<=nlstate;i++){
              cptj=cptj+1;
   strcpy(filerespl,"pl");            for(h=0, gm[h][cptj]=0.; h<=nhstepm-1; h++){
   strcat(filerespl,fileres);  
   if((ficrespl=fopen(filerespl,"w"))==NULL) {              gm[h][cptj] = (p3mat[i][j][h]+p3mat[i][j][h+1])/2.;
     printf("Problem with Prev limit resultfile: %s\n", filerespl);goto end;            }
   }          }
   printf("Computing prevalence limit: result on file '%s' \n", filerespl);        }
   fprintf(ficrespl,"#Prevalence limit\n");        for(j=1; j<= nlstate*nlstate; j++)
   fprintf(ficrespl,"#Age ");          for(h=0; h<=nhstepm-1; h++){
   for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);            gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
   fprintf(ficrespl,"\n");          }
         } 
   prlim=matrix(1,nlstate,1,nlstate);     
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */  /* End theta */
   oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */  
   newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */       trgradg =ma3x(0,nhstepm,1,nlstate*nlstate,1,npar);
   savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */  
   oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */       for(h=0; h<=nhstepm-1; h++)
   k=0;        for(j=1; j<=nlstate*nlstate;j++)
   agebase=agemin;          for(theta=1; theta <=npar; theta++)
   agelim=agemax;            trgradg[h][j][theta]=gradg[h][theta][j];
   ftolpl=1.e-10;       
   i1=cptcovn;  
   if (cptcovn < 1){i1=1;}       for(i=1;i<=nlstate*nlstate;i++)
         for(j=1;j<=nlstate*nlstate;j++)
   for(cptcov=1;cptcov<=i1;cptcov++){          varhe[i][j][(int)age] =0.;
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){  
         k=k+1;       printf("%d|",(int)age);fflush(stdout);
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/       fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
         fprintf(ficrespl,"\n#****** ");       for(h=0;h<=nhstepm-1;h++){
         for(j=1;j<=cptcovn;j++)        for(k=0;k<=nhstepm-1;k++){
           fprintf(ficrespl,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);          matprod2(dnewm,trgradg[h],1,nlstate*nlstate,1,npar,1,npar,matcov);
         fprintf(ficrespl,"******\n");          matprod2(doldm,dnewm,1,nlstate*nlstate,1,npar,1,nlstate*nlstate,gradg[k]);
                  for(i=1;i<=nlstate*nlstate;i++)
         for (age=agebase; age<=agelim; age++){            for(j=1;j<=nlstate*nlstate;j++)
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);              varhe[i][j][(int)age] += doldm[i][j]*hf*hf;
           fprintf(ficrespl,"%.0f",age );        }
           for(i=1; i<=nlstate;i++)      }
           fprintf(ficrespl," %.5f", prlim[i][i]);      /* Computing expectancies */
           fprintf(ficrespl,"\n");      for(i=1; i<=nlstate;i++)
         }        for(j=1; j<=nlstate;j++)
       }          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
     }            eij[i][j][(int)age] += (p3mat[i][j][h]+p3mat[i][j][h+1])/2.0*hf;
   fclose(ficrespl);            
   /*------------- h Pij x at various ages ------------*/  /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
    
   strcpy(filerespij,"pij");  strcat(filerespij,fileres);          }
   if((ficrespij=fopen(filerespij,"w"))==NULL) {  
     printf("Problem with Pij resultfile: %s\n", filerespij);goto end;      fprintf(ficreseij,"%3.0f",age );
   }      cptj=0;
   printf("Computing pij: result on file '%s' \n", filerespij);      for(i=1; i<=nlstate;i++)
          for(j=1; j<=nlstate;j++){
   stepsize=(int) (stepm+YEARM-1)/YEARM;          cptj++;
   if (stepm<=24) stepsize=2;          fprintf(ficreseij," %9.4f (%.4f)", eij[i][j][(int)age], sqrt(varhe[cptj][cptj][(int)age]) );
         }
   agelim=AGESUP;      fprintf(ficreseij,"\n");
   hstepm=stepsize*YEARM; /* Every year of age */     
   hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */      free_matrix(gm,0,nhstepm,1,nlstate*nlstate);
        free_matrix(gp,0,nhstepm,1,nlstate*nlstate);
   k=0;      free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate*nlstate);
   for(cptcov=1;cptcov<=i1;cptcov++){      free_ma3x(trgradg,0,nhstepm,1,nlstate*nlstate,1,npar);
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){      free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       k=k+1;    }
         fprintf(ficrespij,"\n#****** ");    printf("\n");
         for(j=1;j<=cptcovn;j++)    fprintf(ficlog,"\n");
           fprintf(ficrespij,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);  
         fprintf(ficrespij,"******\n");    free_vector(xp,1,npar);
            free_matrix(dnewm,1,nlstate*nlstate,1,npar);
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */    free_matrix(doldm,1,nlstate*nlstate,1,nlstate*nlstate);
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */    free_ma3x(varhe,1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int)fage);
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */  }
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);  
           oldm=oldms;savm=savms;  /************ Variance ******************/
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);    void varevsij(char optionfilefiname[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, int estepm, int cptcov, int cptcod, int popbased, int mobilav)
           fprintf(ficrespij,"# Age");  {
           for(i=1; i<=nlstate;i++)    /* Variance of health expectancies */
             for(j=1; j<=nlstate+ndeath;j++)    /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/
               fprintf(ficrespij," %1d-%1d",i,j);    /* double **newm;*/
           fprintf(ficrespij,"\n");    double **dnewm,**doldm;
           for (h=0; h<=nhstepm; h++){    double **dnewmp,**doldmp;
             fprintf(ficrespij,"%d %.0f %.0f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );    int i, j, nhstepm, hstepm, h, nstepm ;
             for(i=1; i<=nlstate;i++)    int k, cptcode;
               for(j=1; j<=nlstate+ndeath;j++)    double *xp;
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);    double **gp, **gm;  /* for var eij */
             fprintf(ficrespij,"\n");    double ***gradg, ***trgradg; /*for var eij */
           }    double **gradgp, **trgradgp; /* for var p point j */
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    double *gpp, *gmp; /* for var p point j */
           fprintf(ficrespij,"\n");    double **varppt; /* for var p point j nlstate to nlstate+ndeath */
         }    double ***p3mat;
     }    double age,agelim, hf;
   }    double ***mobaverage;
     int theta;
   fclose(ficrespij);    char digit[4];
     char digitp[25];
   /*---------- Health expectancies and variances ------------*/  
     char fileresprobmorprev[FILENAMELENGTH];
   strcpy(filerest,"t");  
   strcat(filerest,fileres);    if(popbased==1){
   if((ficrest=fopen(filerest,"w"))==NULL) {      if(mobilav!=0)
     printf("Problem with total LE resultfile: %s\n", filerest);goto end;        strcpy(digitp,"-populbased-mobilav-");
   }      else strcpy(digitp,"-populbased-nomobil-");
   printf("Computing Total LEs with variances: file '%s' \n", filerest);    }
     else 
       strcpy(digitp,"-stablbased-");
   strcpy(filerese,"e");  
   strcat(filerese,fileres);    if (mobilav!=0) {
   if((ficreseij=fopen(filerese,"w"))==NULL) {      mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);      if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
   }        fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
   printf("Computing Health Expectancies: result on file '%s' \n", filerese);        printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
  strcpy(fileresv,"v");    }
   strcat(fileresv,fileres);  
   if((ficresvij=fopen(fileresv,"w"))==NULL) {    strcpy(fileresprobmorprev,"prmorprev"); 
     printf("Problem with variance resultfile: %s\n", fileresv);exit(0);    sprintf(digit,"%-d",ij);
   }    /*printf("DIGIT=%s, ij=%d ijr=%-d|\n",digit, ij,ij);*/
   printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);    strcat(fileresprobmorprev,digit); /* Tvar to be done */
     strcat(fileresprobmorprev,digitp); /* Popbased or not, mobilav or not */
   k=0;    strcat(fileresprobmorprev,fileres);
   for(cptcov=1;cptcov<=i1;cptcov++){    if((ficresprobmorprev=fopen(fileresprobmorprev,"w"))==NULL) {
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){      printf("Problem with resultfile: %s\n", fileresprobmorprev);
       k=k+1;      fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobmorprev);
       fprintf(ficrest,"\n#****** ");    }
       for(j=1;j<=cptcovn;j++)    printf("Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
         fprintf(ficrest,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);    fprintf(ficlog,"Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
       fprintf(ficrest,"******\n");    fprintf(ficresprobmorprev,"# probabilities of dying before estepm=%d months for people of exact age and weighted probabilities w1*p1j+w2*p2j+... stand dev in()\n",estepm);
     fprintf(ficresprobmorprev,"# Age cov=%-d",ij);
       fprintf(ficreseij,"\n#****** ");    for(j=nlstate+1; j<=(nlstate+ndeath);j++){
       for(j=1;j<=cptcovn;j++)      fprintf(ficresprobmorprev," p.%-d SE",j);
         fprintf(ficreseij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);      for(i=1; i<=nlstate;i++)
       fprintf(ficreseij,"******\n");        fprintf(ficresprobmorprev," w%1d p%-d%-d",i,i,j);
     }  
       fprintf(ficresvij,"\n#****** ");    fprintf(ficresprobmorprev,"\n");
       for(j=1;j<=cptcovn;j++)    fprintf(ficgp,"\n# Routine varevsij");
         fprintf(ficresvij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);    fprintf(fichtm,"\n<li><h4> Computing probabilities of dying over estepm months as a weighted average (i.e global mortality independent of initial healh state)</h4></li>\n");
       fprintf(ficresvij,"******\n");    fprintf(fichtm,"\n<br>%s  <br>\n",digitp);
   /*   } */
       eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);    varppt = matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
       oldm=oldms;savm=savms;  
       evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k);      fprintf(ficresvij,"# Variance and covariance of health expectancies e.j \n#  (weighted average of eij where weights are the stable prevalence in health states i\n");
       vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);    fprintf(ficresvij,"# Age");
       oldm=oldms;savm=savms;    for(i=1; i<=nlstate;i++)
       varevsij(fileres, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);      for(j=1; j<=nlstate;j++)
              fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);
       fprintf(ficrest,"#Total LEs with variances: e.. (std) ");    fprintf(ficresvij,"\n");
       for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);  
       fprintf(ficrest,"\n");    xp=vector(1,npar);
            dnewm=matrix(1,nlstate,1,npar);
       hf=1;    doldm=matrix(1,nlstate,1,nlstate);
       if (stepm >= YEARM) hf=stepm/YEARM;    dnewmp= matrix(nlstate+1,nlstate+ndeath,1,npar);
       epj=vector(1,nlstate+1);    doldmp= matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
       for(age=bage; age <=fage ;age++){  
         prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);    gradgp=matrix(1,npar,nlstate+1,nlstate+ndeath);
         fprintf(ficrest," %.0f",age);    gpp=vector(nlstate+1,nlstate+ndeath);
         for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){    gmp=vector(nlstate+1,nlstate+ndeath);
           for(i=1, epj[j]=0.;i <=nlstate;i++) {    trgradgp =matrix(nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
             epj[j] += prlim[i][i]*hf*eij[i][j][(int)age];    
           }    if(estepm < stepm){
           epj[nlstate+1] +=epj[j];      printf ("Problem %d lower than %d\n",estepm, stepm);
         }    }
         for(i=1, vepp=0.;i <=nlstate;i++)    else  hstepm=estepm;   
           for(j=1;j <=nlstate;j++)    /* For example we decided to compute the life expectancy with the smallest unit */
             vepp += vareij[i][j][(int)age];    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
         fprintf(ficrest," %.2f (%.2f)", epj[nlstate+1],hf*sqrt(vepp));       nhstepm is the number of hstepm from age to agelim 
         for(j=1;j <=nlstate;j++){       nstepm is the number of stepm from age to agelin. 
           fprintf(ficrest," %.2f (%.2f)", epj[j],hf*sqrt(vareij[j][j][(int)age]));       Look at hpijx to understand the reason of that which relies in memory size
         }       and note for a fixed period like k years */
         fprintf(ficrest,"\n");    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
       }       survival function given by stepm (the optimization length). Unfortunately it
     }       means that if the survival funtion is printed every two years of age and if
   }       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
               results. So we changed our mind and took the option of the best precision.
  fclose(ficreseij);    */
  fclose(ficresvij);    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
   fclose(ficrest);    agelim = AGESUP;
   fclose(ficpar);    for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
   free_vector(epj,1,nlstate+1);      nstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
   /*  scanf("%d ",i); */      nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   /*------- Variance limit prevalence------*/        gradg=ma3x(0,nhstepm,1,npar,1,nlstate);
       gp=matrix(0,nhstepm,1,nlstate);
 strcpy(fileresvpl,"vpl");      gm=matrix(0,nhstepm,1,nlstate);
   strcat(fileresvpl,fileres);  
   if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {  
     printf("Problem with variance prev lim resultfile: %s\n", fileresvpl);      for(theta=1; theta <=npar; theta++){
     exit(0);        for(i=1; i<=npar; i++){ /* Computes gradient x + delta*/
   }          xp[i] = x[i] + (i==theta ?delti[theta]:0);
   printf("Computing Variance-covariance of Prevalence limit: file '%s' \n", fileresvpl);        }
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
  k=0;        prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
  for(cptcov=1;cptcov<=i1;cptcov++){  
    for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){        if (popbased==1) {
      k=k+1;          if(mobilav ==0){
      fprintf(ficresvpl,"\n#****** ");            for(i=1; i<=nlstate;i++)
      for(j=1;j<=cptcovn;j++)              prlim[i][i]=probs[(int)age][i][ij];
        fprintf(ficresvpl,"V%d=%d ",Tvar[j],nbcode[Tvar[j]][codtab[k][j]]);          }else{ /* mobilav */ 
      fprintf(ficresvpl,"******\n");            for(i=1; i<=nlstate;i++)
                    prlim[i][i]=mobaverage[(int)age][i][ij];
      varpl=matrix(1,nlstate,(int) bage, (int) fage);          }
      oldm=oldms;savm=savms;        }
      varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);    
    }        for(j=1; j<= nlstate; j++){
  }          for(h=0; h<=nhstepm; h++){
             for(i=1, gp[h][j]=0.;i<=nlstate;i++)
   fclose(ficresvpl);              gp[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
   /*---------- End : free ----------------*/        }
   free_matrix(varpl,1,nlstate,(int) bage, (int)fage);        /* This for computing probability of death (h=1 means
             computed over hstepm matrices product = hstepm*stepm months) 
   free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);           as a weighted average of prlim.
   free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);        */
          for(j=nlstate+1;j<=nlstate+ndeath;j++){
            for(i=1,gpp[j]=0.; i<= nlstate; i++)
   free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);            gpp[j] += prlim[i][i]*p3mat[i][j][1];
   free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);        }    
   free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);        /* end probability of death */
   free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);  
          for(i=1; i<=npar; i++) /* Computes gradient x - delta */
   free_matrix(matcov,1,npar,1,npar);          xp[i] = x[i] - (i==theta ?delti[theta]:0);
   free_vector(delti,1,npar);        hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
          prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
   free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);   
         if (popbased==1) {
   printf("End of Imach\n");          if(mobilav ==0){
   /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */            for(i=1; i<=nlstate;i++)
                prlim[i][i]=probs[(int)age][i][ij];
   /* printf("Total time was %d Sec. %d uSec.\n", end_time.tv_sec -start_time.tv_sec, end_time.tv_usec -start_time.tv_usec);*/          }else{ /* mobilav */ 
   /*printf("Total time was %d uSec.\n", total_usecs);*/            for(i=1; i<=nlstate;i++)
   /*------ End -----------*/              prlim[i][i]=mobaverage[(int)age][i][ij];
           }
  end:        }
 #ifdef windows  
  chdir(pathcd);        for(j=1; j<= nlstate; j++){
 #endif          for(h=0; h<=nhstepm; h++){
  system("wgnuplot graph.plt");            for(i=1, gm[h][j]=0.;i<=nlstate;i++)
               gm[h][j] += prlim[i][i]*p3mat[i][j][h];
 #ifdef windows          }
   while (z[0] != 'q') {        }
     chdir(pathcd);        /* This for computing probability of death (h=1 means
     printf("\nType e to edit output files, c to start again, and q for exiting: ");           computed over hstepm matrices product = hstepm*stepm months) 
     scanf("%s",z);           as a weighted average of prlim.
     if (z[0] == 'c') system("./imach");        */
     else if (z[0] == 'e') {        for(j=nlstate+1;j<=nlstate+ndeath;j++){
       chdir(path);          for(i=1,gmp[j]=0.; i<= nlstate; i++)
       system("index.htm");           gmp[j] += prlim[i][i]*p3mat[i][j][1];
     }        }    
     else if (z[0] == 'q') exit(0);        /* end probability of death */
   }  
 #endif        for(j=1; j<= nlstate; j++) /* vareij */
 }          for(h=0; h<=nhstepm; h++){
             gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
           }
   
         for(j=nlstate+1; j<= nlstate+ndeath; j++){ /* var mu */
           gradgp[theta][j]= (gpp[j]-gmp[j])/2./delti[theta];
         }
   
       } /* End theta */
   
       trgradg =ma3x(0,nhstepm,1,nlstate,1,npar); /* veij */
   
       for(h=0; h<=nhstepm; h++) /* veij */
         for(j=1; j<=nlstate;j++)
           for(theta=1; theta <=npar; theta++)
             trgradg[h][j][theta]=gradg[h][theta][j];
   
       for(j=nlstate+1; j<=nlstate+ndeath;j++) /* mu */
         for(theta=1; theta <=npar; theta++)
           trgradgp[j][theta]=gradgp[theta][j];
     
   
       hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
       for(i=1;i<=nlstate;i++)
         for(j=1;j<=nlstate;j++)
           vareij[i][j][(int)age] =0.;
   
       for(h=0;h<=nhstepm;h++){
         for(k=0;k<=nhstepm;k++){
           matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);
           matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);
           for(i=1;i<=nlstate;i++)
             for(j=1;j<=nlstate;j++)
               vareij[i][j][(int)age] += doldm[i][j]*hf*hf;
         }
       }
     
       /* pptj */
       matprod2(dnewmp,trgradgp,nlstate+1,nlstate+ndeath,1,npar,1,npar,matcov);
       matprod2(doldmp,dnewmp,nlstate+1,nlstate+ndeath,1,npar,nlstate+1,nlstate+ndeath,gradgp);
       for(j=nlstate+1;j<=nlstate+ndeath;j++)
         for(i=nlstate+1;i<=nlstate+ndeath;i++)
           varppt[j][i]=doldmp[j][i];
       /* end ppptj */
       /*  x centered again */
       hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm,savm, ij);  
       prevalim(prlim,nlstate,x,age,oldm,savm,ftolpl,ij);
    
       if (popbased==1) {
         if(mobilav ==0){
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=probs[(int)age][i][ij];
         }else{ /* mobilav */ 
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=mobaverage[(int)age][i][ij];
         }
       }
                
       /* This for computing probability of death (h=1 means
          computed over hstepm (estepm) matrices product = hstepm*stepm months) 
          as a weighted average of prlim.
       */
       for(j=nlstate+1;j<=nlstate+ndeath;j++){
         for(i=1,gmp[j]=0.;i<= nlstate; i++) 
           gmp[j] += prlim[i][i]*p3mat[i][j][1]; 
       }    
       /* end probability of death */
   
       fprintf(ficresprobmorprev,"%3d %d ",(int) age, ij);
       for(j=nlstate+1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprobmorprev," %11.3e %11.3e",gmp[j], sqrt(varppt[j][j]));
         for(i=1; i<=nlstate;i++){
           fprintf(ficresprobmorprev," %11.3e %11.3e ",prlim[i][i],p3mat[i][j][1]);
         }
       } 
       fprintf(ficresprobmorprev,"\n");
   
       fprintf(ficresvij,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           fprintf(ficresvij," %.4f", vareij[i][j][(int)age]);
         }
       fprintf(ficresvij,"\n");
       free_matrix(gp,0,nhstepm,1,nlstate);
       free_matrix(gm,0,nhstepm,1,nlstate);
       free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);
       free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);
       free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     } /* End age */
     free_vector(gpp,nlstate+1,nlstate+ndeath);
     free_vector(gmp,nlstate+1,nlstate+ndeath);
     free_matrix(gradgp,1,npar,nlstate+1,nlstate+ndeath);
     free_matrix(trgradgp,nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     fprintf(ficgp,"\nset noparametric;set nolabel; set ter png small;set size 0.65, 0.65");
     /* for(j=nlstate+1; j<= nlstate+ndeath; j++){ *//* Only the first actually */
     fprintf(ficgp,"\n set log y; set nolog x;set xlabel \"Age\"; set ylabel \"Force of mortality (year-1)\";");
   /*   fprintf(ficgp,"\n plot \"%s\"  u 1:($3*%6.3f) not w l 1 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)*%6.3f) t \"95\%% interval\" w l 2 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)*%6.3f) not w l 2 ",fileresprobmorprev,YEARM/estepm); */
     fprintf(ficgp,"\n plot \"%s\"  u 1:($3) not w l 1 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)) t \"95\%% interval\" w l 2 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)) not w l 2 ",subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> File (multiple files are possible if covariates are present): <A href=\"%s\">%s</a>\n",subdirf(fileresprobmorprev),subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months. <br> <img src=\"%s%s.png\"> <br>\n", estepm,subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
     /*  fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months and then divided by estepm and multiplied by %.0f in order to have the probability to die over a year <br> <img src=\"varmuptjgr%s%s.png\"> <br>\n", stepm,YEARM,digitp,digit);
   */
   /*   fprintf(ficgp,"\nset out \"varmuptjgr%s%s%s.png\";replot;",digitp,optionfilefiname,digit); */
     fprintf(ficgp,"\nset out \"%s%s.png\";replot;\n",subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,nlstate);
     free_matrix(dnewm,1,nlstate,1,npar);
     free_matrix(doldmp,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     free_matrix(dnewmp,nlstate+1,nlstate+ndeath,1,npar);
     free_matrix(varppt,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficresprobmorprev);
     fflush(ficgp);
     fflush(fichtm); 
   }  /* end varevsij */
   
   /************ Variance of prevlim ******************/
   void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)
   {
     /* Variance of prevalence limit */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/
     double **newm;
     double **dnewm,**doldm;
     int i, j, nhstepm, hstepm;
     int k, cptcode;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double age,agelim;
     int theta;
      
     fprintf(ficresvpl,"# Standard deviation of stable prevalences \n");
     fprintf(ficresvpl,"# Age");
     for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %1d-%1d",i,i);
     fprintf(ficresvpl,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     
     hstepm=1*YEARM; /* Every year of age */
     hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       if (stepm >= YEARM) hstepm=1;
       nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
       gradg=matrix(1,npar,1,nlstate);
       gp=vector(1,nlstate);
       gm=vector(1,nlstate);
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient */
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gp[i] = prlim[i][i];
       
         for(i=1; i<=npar; i++) /* Computes gradient */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gm[i] = prlim[i][i];
   
         for(i=1;i<=nlstate;i++)
           gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];
       } /* End theta */
   
       trgradg =matrix(1,nlstate,1,npar);
   
       for(j=1; j<=nlstate;j++)
         for(theta=1; theta <=npar; theta++)
           trgradg[j][theta]=gradg[theta][j];
   
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] =0.;
       matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);
       matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */
   
       fprintf(ficresvpl,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));
       fprintf(ficresvpl,"\n");
       free_vector(gp,1,nlstate);
       free_vector(gm,1,nlstate);
       free_matrix(gradg,1,npar,1,nlstate);
       free_matrix(trgradg,1,nlstate,1,npar);
     } /* End age */
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,npar);
     free_matrix(dnewm,1,nlstate,1,nlstate);
   
   }
   
   /************ Variance of one-step probabilities  ******************/
   void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax)
   {
     int i, j=0,  i1, k1, l1, t, tj;
     int k2, l2, j1,  z1;
     int k=0,l, cptcode;
     int first=1, first1;
     double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp;
     double **dnewm,**doldm;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double **mu;
     double age,agelim, cov[NCOVMAX];
     double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */
     int theta;
     char fileresprob[FILENAMELENGTH];
     char fileresprobcov[FILENAMELENGTH];
     char fileresprobcor[FILENAMELENGTH];
   
     double ***varpij;
   
     strcpy(fileresprob,"prob"); 
     strcat(fileresprob,fileres);
     if((ficresprob=fopen(fileresprob,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprob);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob);
     }
     strcpy(fileresprobcov,"probcov"); 
     strcat(fileresprobcov,fileres);
     if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcov);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov);
     }
     strcpy(fileresprobcor,"probcor"); 
     strcat(fileresprobcor,fileres);
     if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcor);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor);
     }
     printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     
     fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n");
     fprintf(ficresprob,"# Age");
     fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n");
     fprintf(ficresprobcov,"# Age");
     fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n");
     fprintf(ficresprobcov,"# Age");
   
   
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprob," p%1d-%1d (SE)",i,j);
         fprintf(ficresprobcov," p%1d-%1d ",i,j);
         fprintf(ficresprobcor," p%1d-%1d ",i,j);
       }  
    /* fprintf(ficresprob,"\n");
     fprintf(ficresprobcov,"\n");
     fprintf(ficresprobcor,"\n");
    */
    xp=vector(1,npar);
     dnewm=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
     doldm=matrix(1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     mu=matrix(1,(nlstate)*(nlstate+ndeath), (int) bage, (int)fage);
     varpij=ma3x(1,nlstate*(nlstate+ndeath),1,nlstate*(nlstate+ndeath),(int) bage, (int) fage);
     first=1;
     fprintf(ficgp,"\n# Routine varprob");
     fprintf(fichtm,"\n<li><h4> Computing and drawing one step probabilities with their confidence intervals</h4></li>\n");
     fprintf(fichtm,"\n");
   
     fprintf(fichtm,"\n<li><h4> <a href=\"%s\">Matrix of variance-covariance of pairs of step probabilities (drawings)</a></h4></li>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\n<h4>Matrix of variance-covariance of pairs of step probabilities</h4>\n\
     file %s<br>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (p<inf>ij</inf>, p<inf>kl</inf>) are estimated\
   and drawn. It helps understanding how is the covariance between two incidences.\
    They are expressed in year<sup>-1</sup> in order to be less dependent of stepm.<br>\n");
     fprintf(fichtmcov,"\n<br> Contour plot corresponding to x'cov<sup>-1</sup>x = 4 (where x is the column vector (pij,pkl)) are drawn. \
   It can be understood this way: if pij and pkl where uncorrelated the (2x2) matrix of covariance \
   would have been (1/(var pij), 0 , 0, 1/(var pkl)), and the confidence interval would be 2 \
   standard deviations wide on each axis. <br>\
    Now, if both incidences are correlated (usual case) we diagonalised the inverse of the covariance matrix\
    and made the appropriate rotation to look at the uncorrelated principal directions.<br>\
   To be simple, these graphs help to understand the significativity of each parameter in relation to a second other one.<br> \n");
   
     cov[1]=1;
     tj=cptcoveff;
     if (cptcovn<1) {tj=1;ncodemax[1]=1;}
     j1=0;
     for(t=1; t<=tj;t++){
       for(i1=1; i1<=ncodemax[t];i1++){ 
         j1++;
         if  (cptcovn>0) {
           fprintf(ficresprob, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprob, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprob, "**********\n#\n");
           fprintf(ficresprobcov, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcov, "**********\n#\n");
           
           fprintf(ficgp, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficgp, " V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficgp, "**********\n#\n");
           
           
           fprintf(fichtm, "\n<hr  size=\"2\" color=\"#EC5E5E\">********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(fichtm, "**********\n<hr size=\"2\" color=\"#EC5E5E\">");
           
           fprintf(ficresprobcor, "\n#********** Variable ");    
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcor, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcor, "**********\n#");    
         }
         
         for (age=bage; age<=fage; age ++){ 
           cov[2]=age;
           for (k=1; k<=cptcovn;k++) {
             cov[2+k]=nbcode[Tvar[k]][codtab[j1][Tvar[k]]];
           }
           for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
           for (k=1; k<=cptcovprod;k++)
             cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
           
           gradg=matrix(1,npar,1,(nlstate)*(nlstate+ndeath));
           trgradg=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
           gp=vector(1,(nlstate)*(nlstate+ndeath));
           gm=vector(1,(nlstate)*(nlstate+ndeath));
       
           for(theta=1; theta <=npar; theta++){
             for(i=1; i<=npar; i++)
               xp[i] = x[i] + (i==theta ?delti[theta]:(double)0);
             
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             
             k=0;
             for(i=1; i<= (nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gp[k]=pmmij[i][j];
               }
             }
             
             for(i=1; i<=npar; i++)
               xp[i] = x[i] - (i==theta ?delti[theta]:(double)0);
       
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             k=0;
             for(i=1; i<=(nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gm[k]=pmmij[i][j];
               }
             }
        
             for(i=1; i<= (nlstate)*(nlstate+ndeath); i++) 
               gradg[theta][i]=(gp[i]-gm[i])/(double)2./delti[theta];  
           }
   
           for(j=1; j<=(nlstate)*(nlstate+ndeath);j++)
             for(theta=1; theta <=npar; theta++)
               trgradg[j][theta]=gradg[theta][j];
           
           matprod2(dnewm,trgradg,1,(nlstate)*(nlstate+ndeath),1,npar,1,npar,matcov); 
           matprod2(doldm,dnewm,1,(nlstate)*(nlstate+ndeath),1,npar,1,(nlstate)*(nlstate+ndeath),gradg);
           free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
           free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
   
           pmij(pmmij,cov,ncovmodel,x,nlstate);
           
           k=0;
           for(i=1; i<=(nlstate); i++){
             for(j=1; j<=(nlstate+ndeath);j++){
               k=k+1;
               mu[k][(int) age]=pmmij[i][j];
             }
           }
           for(i=1;i<=(nlstate)*(nlstate+ndeath);i++)
             for(j=1;j<=(nlstate)*(nlstate+ndeath);j++)
               varpij[i][j][(int)age] = doldm[i][j];
   
           /*printf("\n%d ",(int)age);
             for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             fprintf(ficlog,"%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             }*/
   
           fprintf(ficresprob,"\n%d ",(int)age);
           fprintf(ficresprobcov,"\n%d ",(int)age);
           fprintf(ficresprobcor,"\n%d ",(int)age);
   
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++)
             fprintf(ficresprob,"%11.3e (%11.3e) ",mu[i][(int) age],sqrt(varpij[i][i][(int)age]));
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             fprintf(ficresprobcov,"%11.3e ",mu[i][(int) age]);
             fprintf(ficresprobcor,"%11.3e ",mu[i][(int) age]);
           }
           i=0;
           for (k=1; k<=(nlstate);k++){
             for (l=1; l<=(nlstate+ndeath);l++){ 
               i=i++;
               fprintf(ficresprobcov,"\n%d %d-%d",(int)age,k,l);
               fprintf(ficresprobcor,"\n%d %d-%d",(int)age,k,l);
               for (j=1; j<=i;j++){
                 fprintf(ficresprobcov," %11.3e",varpij[i][j][(int)age]);
                 fprintf(ficresprobcor," %11.3e",varpij[i][j][(int) age]/sqrt(varpij[i][i][(int) age])/sqrt(varpij[j][j][(int)age]));
               }
             }
           }/* end of loop for state */
         } /* end of loop for age */
   
         /* Confidence intervalle of pij  */
         /*
           fprintf(ficgp,"\nset noparametric;unset label");
           fprintf(ficgp,"\nset log y;unset log x; set xlabel \"Age\";set ylabel \"probability (year-1)\"");
           fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
           fprintf(fichtm,"\n<br>Probability with  confidence intervals expressed in year<sup>-1</sup> :<a href=\"pijgr%s.png\">pijgr%s.png</A>, ",optionfilefiname,optionfilefiname);
           fprintf(fichtm,"\n<br><img src=\"pijgr%s.png\"> ",optionfilefiname);
           fprintf(ficgp,"\nset out \"pijgr%s.png\"",optionfilefiname);
           fprintf(ficgp,"\nplot \"%s\" every :::%d::%d u 1:2 \"\%%lf",k1,k2,xfilevarprob);
         */
   
         /* Drawing ellipsoids of confidence of two variables p(k1-l1,k2-l2)*/
         first1=1;
         for (k2=1; k2<=(nlstate);k2++){
           for (l2=1; l2<=(nlstate+ndeath);l2++){ 
             if(l2==k2) continue;
             j=(k2-1)*(nlstate+ndeath)+l2;
             for (k1=1; k1<=(nlstate);k1++){
               for (l1=1; l1<=(nlstate+ndeath);l1++){ 
                 if(l1==k1) continue;
                 i=(k1-1)*(nlstate+ndeath)+l1;
                 if(i<=j) continue;
                 for (age=bage; age<=fage; age ++){ 
                   if ((int)age %5==0){
                     v1=varpij[i][i][(int)age]/stepm*YEARM/stepm*YEARM;
                     v2=varpij[j][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     cv12=varpij[i][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     mu1=mu[i][(int) age]/stepm*YEARM ;
                     mu2=mu[j][(int) age]/stepm*YEARM;
                     c12=cv12/sqrt(v1*v2);
                     /* Computing eigen value of matrix of covariance */
                     lc1=((v1+v2)+sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     lc2=((v1+v2)-sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     /* Eigen vectors */
                     v11=(1./sqrt(1+(v1-lc1)*(v1-lc1)/cv12/cv12));
                     /*v21=sqrt(1.-v11*v11); *//* error */
                     v21=(lc1-v1)/cv12*v11;
                     v12=-v21;
                     v22=v11;
                     tnalp=v21/v11;
                     if(first1==1){
                       first1=0;
                       printf("%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tang %.3f\nOthers in log...\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     }
                     fprintf(ficlog,"%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tan %.3f\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     /*printf(fignu*/
                     /* mu1+ v11*lc1*cost + v12*lc2*sin(t) */
                     /* mu2+ v21*lc1*cost + v22*lc2*sin(t) */
                     if(first==1){
                       first=0;
                       fprintf(ficgp,"\nset parametric;unset label");
                       fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2);
                       fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
                       fprintf(fichtmcov,"\n<br>Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year<sup>-1</sup>\
    :<a href=\"%s%d%1d%1d-%1d%1d.png\">\
   %s%d%1d%1d-%1d%1d.png</A>, ",k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br><img src=\"%s%d%1d%1d-%1d%1d.png\"> ",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br> Correlation at age %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\"",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }else{
                       first=0;
                       fprintf(fichtmcov," %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }/* if first */
                   } /* age mod 5 */
                 } /* end loop age */
                 fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\";replot;",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                 first=1;
               } /*l12 */
             } /* k12 */
           } /*l1 */
         }/* k1 */
       } /* loop covariates */
     }
     free_ma3x(varpij,1,nlstate,1,nlstate+ndeath,(int) bage, (int)fage);
     free_matrix(mu,1,(nlstate+ndeath)*(nlstate+ndeath),(int) bage, (int)fage);
     free_vector(xp,1,npar);
     fclose(ficresprob);
     fclose(ficresprobcov);
     fclose(ficresprobcor);
     fflush(ficgp);
     fflush(fichtmcov);
   }
   
   
   /******************* Printing html file ***********/
   void printinghtml(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,int jmin, int jmax, double jmeanint,char rfileres[],\
                     int popforecast, int estepm ,\
                     double jprev1, double mprev1,double anprev1, \
                     double jprev2, double mprev2,double anprev2){
     int jj1, k1, i1, cpt;
     /*char optionfilehtm[FILENAMELENGTH];*/
   /*   if((fichtm=fopen(optionfilehtm,"a"))==NULL)    { */
   /*     printf("Problem with %s \n",optionfilehtm), exit(0); */
   /*     fprintf(ficlog,"Problem with %s \n",optionfilehtm), exit(0); */
   /*   } */
   
      fprintf(fichtm,"<ul><li><h4>Result files (first order: no variance)</h4>\n \
    - Observed prevalence in each state (during the period defined between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf): <a href=\"%s\">%s</a> <br>\n \
    - Estimated transition probabilities over %d (stepm) months: <a href=\"%s\">%s</a><br>\n \
    - Stable prevalence in each health state: <a href=\"%s\">%s</a> <br>\n \
    - Life expectancies by age and initial health status (estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>", \
              jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,subdirf2(fileres,"p"),subdirf2(fileres,"p"),\
              stepm,subdirf2(fileres,"pij"),subdirf2(fileres,"pij"),\
              subdirf2(fileres,"pl"),subdirf2(fileres,"pl"),\
              estepm,subdirf2(fileres,"e"),subdirf2(fileres,"e"));
   
   fprintf(fichtm," \n<ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        /* Pij */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i, %d (stepm) months before: %s%d1.png<br> \
   <img src=\"%s%d1.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1);     
        /* Quasi-incidences */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i %d (stepm) months\
    before but expressed in per year i.e. quasi incidences if stepm is small and probabilities too: %s%d2.png<br> \
   <img src=\"%s%d2.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1); 
          /* Stable prevalence in each health state */
          for(cpt=1; cpt<nlstate;cpt++){
            fprintf(fichtm,"<br>- Stable prevalence in each health state : p%s%d%d.png<br> \
   <img src=\"%s%d%d.png\">",subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1);
          }
        for(cpt=1; cpt<=nlstate;cpt++) {
           fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): %s%d%d.png <br> \
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1);
        }
        fprintf(fichtm,"\n<br>- Total life expectancy by age and \
   health expectancies in states (1) and (2): %s%d.png<br>\
   <img src=\"%s%d.png\">",subdirf2(optionfilefiname,"e"),jj1,subdirf2(optionfilefiname,"e"),jj1);
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
   
   
    fprintf(fichtm,"\n<br><li><h4> Result files (second order: variances)</h4>\n\
    - Parameter file with estimated parameters and covariance matrix: <a href=\"%s\">%s</a> <br>\n\
    - Variance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n\
    - Variance-covariance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n\
    - Correlation matrix of one-step probabilities: <a href=\"%s\">%s</a> <br>\n\
    - Variances and covariances of life expectancies by age and initial health status (estepm=%d months): <a href=\"%s\">%s</a><br>\n\
    - Health expectancies with their variances (no covariance): <a href=\"%s\">%s</a> <br>\n\
    - Standard deviation of stable prevalences: <a href=\"%s\">%s</a> <br>\n",\
            rfileres,rfileres,\
            subdirf2(fileres,"prob"),subdirf2(fileres,"prob"),\
            subdirf2(fileres,"probcov"),subdirf2(fileres,"probcov"),\
            subdirf2(fileres,"probcor"),subdirf2(fileres,"probcor"),\
            estepm, subdirf2(fileres,"v"),subdirf2(fileres,"v"),\
            subdirf2(fileres,"t"),subdirf2(fileres,"t"),\
            subdirf2(fileres,"vpl"),subdirf2(fileres,"vpl"));
   
   /*  if(popforecast==1) fprintf(fichtm,"\n */
   /*  - Prevalences forecasting: <a href=\"f%s\">f%s</a> <br>\n */
   /*  - Population forecasting (if popforecast=1): <a href=\"pop%s\">pop%s</a> <br>\n */
   /*      <br>",fileres,fileres,fileres,fileres); */
   /*  else  */
   /*    fprintf(fichtm,"\n No population forecast: popforecast = %d (instead of 1) or stepm = %d (instead of 1) or model=%s (instead of .)<br><br></li>\n",popforecast, stepm, model); */
   fprintf(fichtm," <ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        for(cpt=1; cpt<=nlstate;cpt++) {
          fprintf(fichtm,"<br>- Observed (cross-sectional) and period (incidence based) \
   prevalence (with 95%% confidence interval) in state (%d): %s%d%d.png <br>\
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"v"),cpt,jj1,subdirf2(optionfilefiname,"v"),cpt,jj1);  
        }
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
    fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplot(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   /*   if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */
   /*     printf("Problem with file %s",optionfilegnuplot); */
   /*     fprintf(ficlog,"Problem with file %s",optionfilegnuplot); */
   /*   } */
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
     m=pow(2,cptcoveff);
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
    /* 1eme*/
     for (cpt=1; cpt<= nlstate ; cpt ++) {
      for (k1=1; k1<= m ; k1 ++) {
        fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"v"),cpt,k1);
        fprintf(ficgp,"\n#set out \"v%s%d%d.png\" \n",optionfilefiname,cpt,k1);
        fprintf(ficgp,"set xlabel \"Age\" \n\
   set ylabel \"Probability\" \n\
   set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:2 \"\%%lf",ageminpar,fage,subdirf2(fileres,"vpl"),k1-1,k1-1);
   
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }
        fprintf(ficgp,"\" t\"Stable prevalence\" w l 0,\"%s\" every :::%d::%d u 1:($2+1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1);
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        } 
        fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"%s\" every :::%d::%d u 1:($2-1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1); 
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }  
        fprintf(ficgp,"\" t\"\" w l 1,\"%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",subdirf2(fileres,"p"),k1-1,k1-1,2+4*(cpt-1));
      }
     }
     /*2 eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       fprintf(ficgp,"\nset out \"%s%d.png\" \n",subdirf2(optionfilefiname,"e"),k1);
       fprintf(ficgp,"set ylabel \"Years\" \nset ter png small\nset size 0.65,0.65\nplot [%.f:%.f] ",ageminpar,fage);
       
       for (i=1; i<= nlstate+1 ; i ++) {
         k=2*i;
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:2 \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");
         else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         fprintf(ficgp,"\" t\"\" w l 0,");
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");
         else fprintf(ficgp,"\" t\"\" w l 0,");
       }
     }
     
     /*3eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<= nlstate ; cpt ++) {
         k=2+nlstate*(2*cpt-2);
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"exp"),cpt,k1);
         fprintf(ficgp,"set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",ageminpar,fage,subdirf2(fileres,"e"),k1-1,k1-1,k,cpt);
         /*fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d-2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d+2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           
         */
         for (i=1; i< nlstate ; i ++) {
           fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+2*i,cpt,i+1);
           
         } 
       }
     }
     
     /* CV preval stable (period) */
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<=nlstate ; cpt ++) {
         k=3;
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"p"),cpt,k1);
         fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\
   set ter png small\nset size 0.65,0.65\n\
   unset log y\n\
   plot [%.f:%.f] \"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",ageminpar,agemaxpar,subdirf2(fileres,"pij"),k1,k+cpt+1,k+1);
         
         for (i=1; i< nlstate ; i ++)
           fprintf(ficgp,"+$%d",k+i+1);
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);
         
         l=3+(nlstate+ndeath)*cpt;
         fprintf(ficgp,",\"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",subdirf2(fileres,"pij"),k1,l+cpt+1,l+1);
         for (i=1; i< nlstate ; i ++) {
           l=3+(nlstate+ndeath)*cpt;
           fprintf(ficgp,"+$%d",l+i+1);
         }
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);   
       } 
     }  
     
     /* proba elementaires */
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           for(j=1; j <=ncovmodel; j++){
             fprintf(ficgp,"p%d=%f ",jk,p[jk]);
             jk++; 
             fprintf(ficgp,"\n");
           }
         }
       }
      }
   
      for(ng=1; ng<=2;ng++){ /* Number of graphics: first is probabilities second is incidence per year*/
        for(jk=1; jk <=m; jk++) {
          fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"pe"),jk,ng); 
          if (ng==2)
            fprintf(ficgp,"\nset ylabel \"Quasi-incidence per year\"\n");
          else
            fprintf(ficgp,"\nset title \"Probability\"\n");
          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65\nset log y\nplot  [%.f:%.f] ",ageminpar,agemaxpar);
          i=1;
          for(k2=1; k2<=nlstate; k2++) {
            k3=i;
            for(k=1; k<=(nlstate+ndeath); k++) {
              if (k != k2){
                if(ng==2)
                  fprintf(ficgp," %f*exp(p%d+p%d*x",YEARM/stepm,i,i+1);
                else
                  fprintf(ficgp," exp(p%d+p%d*x",i,i+1);
                ij=1;
                for(j=3; j <=ncovmodel; j++) {
                  if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                    fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                    ij++;
                  }
                  else
                    fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                }
                fprintf(ficgp,")/(1");
                
                for(k1=1; k1 <=nlstate; k1++){   
                  fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);
                  ij=1;
                  for(j=3; j <=ncovmodel; j++){
                    if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                      fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                      ij++;
                    }
                    else
                      fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                  }
                  fprintf(ficgp,")");
                }
                fprintf(ficgp,") t \"p%d%d\" ", k2,k);
                if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");
                i=i+ncovmodel;
              }
            } /* end k */
          } /* end k2 */
        } /* end jk */
      } /* end ng */
      fflush(ficgp); 
   }  /* end gnuplot */
   
   
   /*************** Moving average **************/
   int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav){
   
     int i, cpt, cptcod;
     int modcovmax =1;
     int mobilavrange, mob;
     double age;
   
     modcovmax=2*cptcoveff;/* Max number of modalities. We suppose 
                              a covariate has 2 modalities */
     if (cptcovn<1) modcovmax=1; /* At least 1 pass */
   
     if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){
       if(mobilav==1) mobilavrange=5; /* default */
       else mobilavrange=mobilav;
       for (age=bage; age<=fage; age++)
         for (i=1; i<=nlstate;i++)
           for (cptcod=1;cptcod<=modcovmax;cptcod++)
             mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod];
       /* We keep the original values on the extreme ages bage, fage and for 
          fage+1 and bage-1 we use a 3 terms moving average; for fage+2 bage+2
          we use a 5 terms etc. until the borders are no more concerned. 
       */ 
       for (mob=3;mob <=mobilavrange;mob=mob+2){
         for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){
           for (i=1; i<=nlstate;i++){
             for (cptcod=1;cptcod<=modcovmax;cptcod++){
               mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod];
                 for (cpt=1;cpt<=(mob-1)/2;cpt++){
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod];
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod];
                 }
               mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob;
             }
           }
         }/* end age */
       }/* end mob */
     }else return -1;
     return 0;
   }/* End movingaverage */
   
   
   /************** Forecasting ******************/
   prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){
     /* proj1, year, month, day of starting projection 
        agemin, agemax range of age
        dateprev1 dateprev2 range of dates during which prevalence is computed
        anproj2 year of en of projection (same day and month as proj1).
     */
     int yearp, stepsize, hstepm, nhstepm, j, k, c, cptcod, i, h, i1;
     int *popage;
     double agec; /* generic age */
     double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean;
     double *popeffectif,*popcount;
     double ***p3mat;
     double ***mobaverage;
     char fileresf[FILENAMELENGTH];
   
     agelim=AGESUP;
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
    
     strcpy(fileresf,"f"); 
     strcat(fileresf,fileres);
     if((ficresf=fopen(fileresf,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", fileresf);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", fileresf);
     }
     printf("Computing forecasting: result on file '%s' \n", fileresf);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", fileresf);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
   
     hstepm=hstepm/stepm; 
     yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp  and
                                  fractional in yp1 */
     anprojmean=yp;
     yp2=modf((yp1*12),&yp);
     mprojmean=yp;
     yp1=modf((yp2*30.5),&yp);
     jprojmean=yp;
     if(jprojmean==0) jprojmean=1;
     if(mprojmean==0) jprojmean=1;
   
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
     
     fprintf(ficresf,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); 
     
     fprintf(ficresf,"#****** Routine prevforecast **\n");
   
   /*            if (h==(int)(YEARM*yearp)){ */
     for(cptcov=1, k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficresf,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficresf," V%d=%d, hpijx=probability over h years, hp.jx is weighted by observed prev ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficresf,"******\n");
         fprintf(ficresf,"# Covariate valuofcovar yearproj age");
         for(j=1; j<=nlstate+ndeath;j++){ 
           for(i=1; i<=nlstate;i++)              
             fprintf(ficresf," p%d%d",i,j);
           fprintf(ficresf," p.%d",j);
         }
         for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { 
           fprintf(ficresf,"\n");
           fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp);   
   
           for (agec=fage; agec>=(ageminpar-1); agec--){ 
             nhstepm=(int) rint((agelim-agec)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h*hstepm/YEARM*stepm ==yearp) {
                 fprintf(ficresf,"\n");
                 for(j=1;j<=cptcoveff;j++) 
                   fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
                 fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 ppij=0.;
                 for(i=1; i<=nlstate;i++) {
                   if (mobilav==1) 
                     ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod];
                   else {
                     ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod];
                   }
                   if (h*hstepm/YEARM*stepm== yearp) {
                     fprintf(ficresf," %.3f", p3mat[i][j][h]);
                   }
                 } /* end i */
                 if (h*hstepm/YEARM*stepm==yearp) {
                   fprintf(ficresf," %.3f", ppij);
                 }
               }/* end j */
             } /* end h */
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           } /* end agec */
         } /* end yearp */
       } /* end cptcod */
     } /* end  cptcov */
          
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     fclose(ficresf);
   }
   
   /************** Forecasting *****not tested NB*************/
   populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){
     
     int cpt, stepsize, hstepm, nhstepm, j,k,c, cptcod, i,h;
     int *popage;
     double calagedatem, agelim, kk1, kk2;
     double *popeffectif,*popcount;
     double ***p3mat,***tabpop,***tabpopprev;
     double ***mobaverage;
     char filerespop[FILENAMELENGTH];
   
     tabpop= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     tabpopprev= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     agelim=AGESUP;
     calagedatem=(anpyram+mpyram/12.+jpyram/365.-dateintmean)*YEARM;
     
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     
     
     strcpy(filerespop,"pop"); 
     strcat(filerespop,fileres);
     if((ficrespop=fopen(filerespop,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", filerespop);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", filerespop);
     }
     printf("Computing forecasting: result on file '%s' \n", filerespop);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", filerespop);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     
     agelim=AGESUP;
     
     hstepm=1;
     hstepm=hstepm/stepm; 
     
     if (popforecast==1) {
       if((ficpop=fopen(popfile,"r"))==NULL) {
         printf("Problem with population file : %s\n",popfile);exit(0);
         fprintf(ficlog,"Problem with population file : %s\n",popfile);exit(0);
       } 
       popage=ivector(0,AGESUP);
       popeffectif=vector(0,AGESUP);
       popcount=vector(0,AGESUP);
       
       i=1;   
       while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF) i=i+1;
      
       imx=i;
       for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];
     }
   
     for(cptcov=1,k=0;cptcov<=i2;cptcov++){
      for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficrespop,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespop," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespop,"******\n");
         fprintf(ficrespop,"# Age");
         for(j=1; j<=nlstate+ndeath;j++) fprintf(ficrespop," P.%d",j);
         if (popforecast==1)  fprintf(ficrespop," [Population]");
         
         for (cpt=0; cpt<=0;cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficrespop,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   if (mobilav==1) 
                     kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb+1][i][cptcod];
                   else {
                     kk1=kk1+p3mat[i][j][h]*probs[(int)(agedeb+1)][i][cptcod];
                   }
                 }
                 if (h==(int)(calagedatem+12*cpt)){
                   tabpop[(int)(agedeb)][j][cptcod]=kk1;
                     /*fprintf(ficrespop," %.3f", kk1);
                       if (popforecast==1) fprintf(ficrespop," [%.f]", kk1*popeffectif[(int)agedeb+1]);*/
                 }
               }
               for(i=1; i<=nlstate;i++){
                 kk1=0.;
                   for(j=1; j<=nlstate;j++){
                     kk1= kk1+tabpop[(int)(agedeb)][j][cptcod]; 
                   }
                     tabpopprev[(int)(agedeb)][i][cptcod]=tabpop[(int)(agedeb)][i][cptcod]/kk1*popeffectif[(int)(agedeb+(calagedatem+12*cpt)*hstepm/YEARM*stepm-1)];
               }
   
               if (h==(int)(calagedatem+12*cpt)) for(j=1; j<=nlstate;j++) 
                 fprintf(ficrespop," %15.2f",tabpopprev[(int)(agedeb+1)][j][cptcod]);
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
    
     /******/
   
         for (cpt=1; cpt<=(anpyram1-anpyram);cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficresf,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   kk1=kk1+p3mat[i][j][h]*tabpopprev[(int)agedeb+1][i][cptcod];    
                 }
                 if (h==(int)(calagedatem+12*cpt)) fprintf(ficresf," %15.2f", kk1);        
               }
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
      } 
     }
    
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     if (popforecast==1) {
       free_ivector(popage,0,AGESUP);
       free_vector(popeffectif,0,AGESUP);
       free_vector(popcount,0,AGESUP);
     }
     free_ma3x(tabpop,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(tabpopprev,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficrespop);
   } /* End of popforecast */
   
   int fileappend(FILE *fichier, char *optionfich)
   {
     if((fichier=fopen(optionfich,"a"))==NULL) {
       printf("Problem with file: %s\n", optionfich);
       fprintf(ficlog,"Problem with file: %s\n", optionfich);
       return (0);
     }
     fflush(fichier);
     return (1);
   }
   
   
   /**************** function prwizard **********************/
   void prwizard(int ncovmodel, int nlstate, int ndeath,  char model[], FILE *ficparo)
   {
   
     /* Wizard to print covariance matrix template */
   
     char ca[32], cb[32], cc[32];
     int i,j, k, l, li, lj, lk, ll, jj, npar, itimes;
     int numlinepar;
   
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficparo,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         /*ca[0]= k+'a'-1;ca[1]='\0';*/
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           /*        printf(" %lf",param[i][j][k]); */
           /*        fprintf(ficparo," %lf",param[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficparo,"# Scales (for hessian or gradient estimation)\n");
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/ 
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         fprintf(ficparo,"%1d%1d",i,j);
         printf("%1d%1d",i,j);
         fflush(stdout);
         for(k=1; k<=ncovmodel;k++){
           /*      printf(" %le",delti3[i][j][k]); */
           /*      fprintf(ficparo," %le",delti3[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Covariance matrix\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
     fflush(stdout);
     fprintf(ficparo,"# Covariance matrix\n");
     /* # 121 Var(a12)\n\ */
     /* # 122 Cov(b12,a12) Var(b12)\n\ */
     /* #   ...\n\ */
     /* # 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n" */
     
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               printf("#%1d%1d%d",i,j,k);
               fprintf(ficparo,"#%1d%1d%d",i,j,k);
             }else{
               printf("%1d%1d%d",i,j,k);
               fprintf(ficparo,"%1d%1d%d",i,j,k);
               /*  printf(" %.5le",matcov[i][j]); */
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficparo," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }else{
                       if(itimes==1){
                         printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficparo," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             printf("\n");
             fprintf(ficparo,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
   } /* end of prwizard */
   
   
   /***********************************************/
   /**************** Main Program *****************/
   /***********************************************/
   
   int main(int argc, char *argv[])
   {
     int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav);
     int i,j, k, n=MAXN,iter,m,size=100,cptcode, cptcod;
     int jj, ll, li, lj, lk, imk;
     int numlinepar=0; /* Current linenumber of parameter file */
     int itimes;
   
     char ca[32], cb[32], cc[32];
     /*  FILE *fichtm; *//* Html File */
     /* FILE *ficgp;*/ /*Gnuplot File */
     double agedeb, agefin,hf;
     double ageminpar=1.e20,agemin=1.e20, agemaxpar=-1.e20, agemax=-1.e20;
   
     double fret;
     double **xi,tmp,delta;
   
     double dum; /* Dummy variable */
     double ***p3mat;
     double ***mobaverage;
     int *indx;
     char line[MAXLINE], linepar[MAXLINE];
     char path[MAXLINE],pathc[MAXLINE],pathcd[MAXLINE],pathtot[MAXLINE],model[MAXLINE];
     char pathr[MAXLINE]; 
     int firstobs=1, lastobs=10;
     int sdeb, sfin; /* Status at beginning and end */
     int c,  h , cpt,l;
     int ju,jl, mi;
     int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;
     int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,*tab; 
     int mobilavproj=0 , prevfcast=0 ; /* moving average of prev, If prevfcast=1 prevalence projection */
     int mobilav=0,popforecast=0;
     int hstepm, nhstepm;
     double jprev1=1, mprev1=1,anprev1=2000,jprev2=1, mprev2=1,anprev2=2000;
     double jpyram=1, mpyram=1,anpyram=2000,jpyram1=1, mpyram1=1,anpyram1=2000;
   
     double bage, fage, age, agelim, agebase;
     double ftolpl=FTOL;
     double **prlim;
     double *severity;
     double ***param; /* Matrix of parameters */
     double  *p;
     double **matcov; /* Matrix of covariance */
     double ***delti3; /* Scale */
     double *delti; /* Scale */
     double ***eij, ***vareij;
     double **varpl; /* Variances of prevalence limits by age */
     double *epj, vepp;
     double kk1, kk2;
     double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000;
   
     char *alph[]={"a","a","b","c","d","e"}, str[4];
   
   
     char z[1]="c", occ;
   
     char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];
     char strstart[80], *strt, strtend[80];
     char *stratrunc;
     int lstra;
   
     long total_usecs;
    
   /*   setlocale (LC_ALL, ""); */
   /*   bindtextdomain (PACKAGE, LOCALEDIR); */
   /*   textdomain (PACKAGE); */
   /*   setlocale (LC_CTYPE, ""); */
   /*   setlocale (LC_MESSAGES, ""); */
   
     /*   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */
     (void) gettimeofday(&start_time,&tzp);
     curr_time=start_time;
     tm = *localtime(&start_time.tv_sec);
     tmg = *gmtime(&start_time.tv_sec);
     strcpy(strstart,asctime(&tm));
   
   /*  printf("Localtime (at start)=%s",strstart); */
   /*  tp.tv_sec = tp.tv_sec +86400; */
   /*  tm = *localtime(&start_time.tv_sec); */
   /*   tmg.tm_year=tmg.tm_year +dsign*dyear; */
   /*   tmg.tm_mon=tmg.tm_mon +dsign*dmonth; */
   /*   tmg.tm_hour=tmg.tm_hour + 1; */
   /*   tp.tv_sec = mktime(&tmg); */
   /*   strt=asctime(&tmg); */
   /*   printf("Time(after) =%s",strstart);  */
   /*  (void) time (&time_value);
   *  printf("time=%d,t-=%d\n",time_value,time_value-86400);
   *  tm = *localtime(&time_value);
   *  strstart=asctime(&tm);
   *  printf("tim_value=%d,asctime=%s\n",time_value,strstart); 
   */
   
     nberr=0; /* Number of errors and warnings */
     nbwarn=0;
     getcwd(pathcd, size);
   
     printf("\n%s\n%s",version,fullversion);
     if(argc <=1){
       printf("\nEnter the parameter file name: ");
       scanf("%s",pathtot);
     }
     else{
       strcpy(pathtot,argv[1]);
     }
     /*if(getcwd(pathcd, MAXLINE)!= NULL)printf ("Error pathcd\n");*/
     /*cygwin_split_path(pathtot,path,optionfile);
       printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/
     /* cutv(path,optionfile,pathtot,'\\');*/
   
     split(pathtot,path,optionfile,optionfilext,optionfilefiname);
     printf("pathtot=%s,\npath=%s,\noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
     chdir(path);
     strcpy(command,"mkdir ");
     strcat(command,optionfilefiname);
     if((outcmd=system(command)) != 0){
       printf("Problem creating directory or it already exists %s%s, err=%d\n",path,optionfilefiname,outcmd);
       /* fprintf(ficlog,"Problem creating directory %s%s\n",path,optionfilefiname); */
       /* fclose(ficlog); */
   /*     exit(1); */
     }
   /*   if((imk=mkdir(optionfilefiname))<0){ */
   /*     perror("mkdir"); */
   /*   } */
   
     /*-------- arguments in the command line --------*/
   
     /* Log file */
     strcat(filelog, optionfilefiname);
     strcat(filelog,".log");    /* */
     if((ficlog=fopen(filelog,"w"))==NULL)    {
       printf("Problem with logfile %s\n",filelog);
       goto end;
     }
     fprintf(ficlog,"Log filename:%s\n",filelog);
     fprintf(ficlog,"\n%s\n%s",version,fullversion);
     fprintf(ficlog,"\nEnter the parameter file name: ");
     fprintf(ficlog,"pathtot=%s\n\
    path=%s \n\
    optionfile=%s\n\
    optionfilext=%s\n\
    optionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
   
     printf("Local time (at start):%s",strstart);
     fprintf(ficlog,"Local time (at start): %s",strstart);
     fflush(ficlog);
   /*   (void) gettimeofday(&curr_time,&tzp); */
   /*   printf("Elapsed time %d\n", asc_diff_time(curr_time.tv_sec-start_time.tv_sec,tmpout)); */
   
     /* */
     strcpy(fileres,"r");
     strcat(fileres, optionfilefiname);
     strcat(fileres,".txt");    /* Other files have txt extension */
   
     /*---------arguments file --------*/
   
     if((ficpar=fopen(optionfile,"r"))==NULL)    {
       printf("Problem with optionfile %s\n",optionfile);
       fprintf(ficlog,"Problem with optionfile %s\n",optionfile);
       fflush(ficlog);
       goto end;
     }
   
   
   
     strcpy(filereso,"o");
     strcat(filereso,fileres);
     if((ficparo=fopen(filereso,"w"))==NULL) { /* opened on subdirectory */
       printf("Problem with Output resultfile: %s\n", filereso);
       fprintf(ficlog,"Problem with Output resultfile: %s\n", filereso);
       fflush(ficlog);
       goto end;
     }
   
     /* Reads comments: lines beginning with '#' */
     numlinepar=0;
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d model=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncovcol, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);
     numlinepar++;
     printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate,ndeath, maxwav, mle, weightopt,model);
     fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fprintf(ficlog,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fflush(ficlog);
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
      
     covar=matrix(0,NCOVMAX,1,n); 
     cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement*/
     if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;
   
     ncovmodel=2+cptcovn; /*Number of variables = cptcovn + intercept + age */
     nvar=ncovmodel-1; /* Suppressing age as a basic covariate */
    
     if(mle==-1){ /* Print a wizard for help writing covariance matrix */
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fclose (ficparo);
       fclose (ficlog);
       exit(0);
     }
     /* Read guess parameters */
     /* Reads comments: lines beginning with '#' */
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     for(i=1; i <=nlstate; i++){
       j=0;
       for(jj=1; jj <=nlstate+ndeath; jj++){
         if(jj==i) continue;
         j++;
         fscanf(ficpar,"%1d%1d",&i1,&j1);
         if ((i1 != i) && (j1 != j)){
           printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
           exit(1);
         }
         fprintf(ficparo,"%1d%1d",i1,j1);
         if(mle==1)
           printf("%1d%1d",i,j);
         fprintf(ficlog,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           fscanf(ficpar," %lf",&param[i][j][k]);
           if(mle==1){
             printf(" %lf",param[i][j][k]);
             fprintf(ficlog," %lf",param[i][j][k]);
           }
           else
             fprintf(ficlog," %lf",param[i][j][k]);
           fprintf(ficparo," %lf",param[i][j][k]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         if(mle==1)
           printf("\n");
         fprintf(ficlog,"\n");
         fprintf(ficparo,"\n");
       }
     }  
     fflush(ficlog);
   
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/
   
     p=param[1][1];
     
     /* Reads comments: lines beginning with '#' */
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     /* delti=vector(1,npar); *//* Scale of each paramater (output from hesscov) */
     for(i=1; i <=nlstate; i++){
       for(j=1; j <=nlstate+ndeath-1; j++){
         fscanf(ficpar,"%1d%1d",&i1,&j1);
         if ((i1-i)*(j1-j)!=0){
           printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
           exit(1);
         }
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i1,j1);
         fprintf(ficlog,"%1d%1d",i1,j1);
         for(k=1; k<=ncovmodel;k++){
           fscanf(ficpar,"%le",&delti3[i][j][k]);
           printf(" %le",delti3[i][j][k]);
           fprintf(ficparo," %le",delti3[i][j][k]);
           fprintf(ficlog," %le",delti3[i][j][k]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
         fprintf(ficlog,"\n");
       }
     }
     fflush(ficlog);
   
     delti=delti3[1][1];
   
   
     /* free_ma3x(delti3,1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ /* Hasn't to to freed here otherwise delti is no more allocated */
     
     /* Reads comments: lines beginning with '#' */
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
     
     matcov=matrix(1,npar,1,npar);
     for(i=1; i <=npar; i++){
       fscanf(ficpar,"%s",&str);
       if(mle==1)
         printf("%s",str);
       fprintf(ficlog,"%s",str);
       fprintf(ficparo,"%s",str);
       for(j=1; j <=i; j++){
         fscanf(ficpar," %le",&matcov[i][j]);
         if(mle==1){
           printf(" %.5le",matcov[i][j]);
         }
         fprintf(ficlog," %.5le",matcov[i][j]);
         fprintf(ficparo," %.5le",matcov[i][j]);
       }
       fscanf(ficpar,"\n");
       numlinepar++;
       if(mle==1)
         printf("\n");
       fprintf(ficlog,"\n");
       fprintf(ficparo,"\n");
     }
     for(i=1; i <=npar; i++)
       for(j=i+1;j<=npar;j++)
         matcov[i][j]=matcov[j][i];
      
     if(mle==1)
       printf("\n");
     fprintf(ficlog,"\n");
   
     fflush(ficlog);
   
     /*-------- Rewriting paramater file ----------*/
     strcpy(rfileres,"r");    /* "Rparameterfile */
     strcat(rfileres,optionfilefiname);    /* Parameter file first name*/
     strcat(rfileres,".");    /* */
     strcat(rfileres,optionfilext);    /* Other files have txt extension */
     if((ficres =fopen(rfileres,"w"))==NULL) {
       printf("Problem writing new parameter file: %s\n", fileres);goto end;
       fprintf(ficlog,"Problem writing new parameter file: %s\n", fileres);goto end;
     }
     fprintf(ficres,"#%s\n",version);
       
     /*-------- data file ----------*/
     if((fic=fopen(datafile,"r"))==NULL)    {
       printf("Problem with datafile: %s\n", datafile);goto end;
       fprintf(ficlog,"Problem with datafile: %s\n", datafile);goto end;
     }
   
     n= lastobs;
     severity = vector(1,maxwav);
     outcome=imatrix(1,maxwav+1,1,n);
     num=lvector(1,n);
     moisnais=vector(1,n);
     annais=vector(1,n);
     moisdc=vector(1,n);
     andc=vector(1,n);
     agedc=vector(1,n);
     cod=ivector(1,n);
     weight=vector(1,n);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */
     mint=matrix(1,maxwav,1,n);
     anint=matrix(1,maxwav,1,n);
     s=imatrix(1,maxwav+1,1,n);
     tab=ivector(1,NCOVMAX);
     ncodemax=ivector(1,8);
   
     i=1;
     while (fgets(line, MAXLINE, fic) != NULL)    {
       if ((i >= firstobs) && (i <=lastobs)) {
           
         for (j=maxwav;j>=1;j--){
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb); 
           strcpy(line,stra);
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);
         }
           
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);
   
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);
   
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);
         for (j=ncovcol;j>=1;j--){
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);
         } 
         lstra=strlen(stra);
         if(lstra > 9){ /* More than 2**32 or max of what printf can write with %ld */
           stratrunc = &(stra[lstra-9]);
           num[i]=atol(stratrunc);
         }
         else
           num[i]=atol(stra);
           
         /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){
           printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/
   
         i=i+1;
       }
     }
     /* printf("ii=%d", ij);
        scanf("%d",i);*/
     imx=i-1; /* Number of individuals */
   
     /* for (i=1; i<=imx; i++){
       if ((s[1][i]==3) && (s[2][i]==2)) s[2][i]=3;
       if ((s[2][i]==3) && (s[3][i]==2)) s[3][i]=3;
       if ((s[3][i]==3) && (s[4][i]==2)) s[4][i]=3;
       }*/
      /*  for (i=1; i<=imx; i++){
        if (s[4][i]==9)  s[4][i]=-1; 
        printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));}*/
     
    for (i=1; i<=imx; i++)
    
      /*if ((s[3][i]==3) ||  (s[4][i]==3)) weight[i]=0.08;
        else weight[i]=1;*/
   
     /* Calculation of the number of parameter from char model*/
     Tvar=ivector(1,15); /* stores the number n of the covariates in Vm+Vn at 1 and m at 2 */
     Tprod=ivector(1,15); 
     Tvaraff=ivector(1,15); 
     Tvard=imatrix(1,15,1,2);
     Tage=ivector(1,15);      
      
     if (strlen(model) >1){ /* If there is at least 1 covariate */
       j=0, j1=0, k1=1, k2=1;
       j=nbocc(model,'+'); /* j=Number of '+' */
       j1=nbocc(model,'*'); /* j1=Number of '*' */
       cptcovn=j+1; 
       cptcovprod=j1; /*Number of products */
       
       strcpy(modelsav,model); 
       if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){
         printf("Error. Non available option model=%s ",model);
         fprintf(ficlog,"Error. Non available option model=%s ",model);
         goto end;
       }
       
       /* This loop fills the array Tvar from the string 'model'.*/
   
       for(i=(j+1); i>=1;i--){
         cutv(stra,strb,modelsav,'+'); /* keeps in strb after the last + */ 
         if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav); /* and analyzes it */
         /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/
         /*scanf("%d",i);*/
         if (strchr(strb,'*')) {  /* Model includes a product */
           cutv(strd,strc,strb,'*'); /* strd*strc  Vm*Vn (if not *age)*/
           if (strcmp(strc,"age")==0) { /* Vn*age */
             cptcovprod--;
             cutv(strb,stre,strd,'V');
             Tvar[i]=atoi(stre); /* computes n in Vn and stores in Tvar*/
             cptcovage++;
               Tage[cptcovage]=i;
               /*printf("stre=%s ", stre);*/
           }
           else if (strcmp(strd,"age")==0) { /* or age*Vn */
             cptcovprod--;
             cutv(strb,stre,strc,'V');
             Tvar[i]=atoi(stre);
             cptcovage++;
             Tage[cptcovage]=i;
           }
           else {  /* Age is not in the model */
             cutv(strb,stre,strc,'V'); /* strc= Vn, stre is n*/
             Tvar[i]=ncovcol+k1;
             cutv(strb,strc,strd,'V'); /* strd was Vm, strc is m */
             Tprod[k1]=i;
             Tvard[k1][1]=atoi(strc); /* m*/
             Tvard[k1][2]=atoi(stre); /* n */
             Tvar[cptcovn+k2]=Tvard[k1][1];
             Tvar[cptcovn+k2+1]=Tvard[k1][2]; 
             for (k=1; k<=lastobs;k++) 
               covar[ncovcol+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];
             k1++;
             k2=k2+2;
           }
         }
         else { /* no more sum */
           /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/
          /*  scanf("%d",i);*/
         cutv(strd,strc,strb,'V');
         Tvar[i]=atoi(strc);
         }
         strcpy(modelsav,stra);  
         /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);
           scanf("%d",i);*/
       } /* end of loop + */
     } /* end model */
     
     /*The number n of Vn is stored in Tvar. cptcovage =number of age covariate. Tage gives the position of age. cptcovprod= number of products.
       If model=V1+V1*age then Tvar[1]=1 Tvar[2]=1 cptcovage=1 Tage[1]=2 cptcovprod=0*/
   
     /* printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);
     printf("cptcovprod=%d ", cptcovprod);
     fprintf(ficlog,"cptcovprod=%d ", cptcovprod);
   
     scanf("%d ",i);
     fclose(fic);*/
   
       /*  if(mle==1){*/
     if (weightopt != 1) { /* Maximisation without weights*/
       for(i=1;i<=n;i++) weight[i]=1.0;
     }
       /*-calculation of age at interview from date of interview and age at death -*/
     agev=matrix(1,maxwav,1,imx);
   
     for (i=1; i<=imx; i++) {
       for(m=2; (m<= maxwav); m++) {
         if (((int)mint[m][i]== 99) && (s[m][i] <= nlstate)){
           anint[m][i]=9999;
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]==9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           fprintf(ficlog,"Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]!=9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Month of death of individual %ld on line %d was unknown %2d, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,(int)moisdc[i]); 
           fprintf(ficlog,"Error! Month of death of individual %ld on line %d was unknown %f, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,moisdc[i]); 
           s[m][i]=-1; /* We prefer to skip it (and to skip it in version 0.8a1 too */
         }
       }
     }
   
     for (i=1; i<=imx; i++)  {
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);
       for(m=firstpass; (m<= lastpass); m++){
         if(s[m][i] >0){
           if (s[m][i] >= nlstate+1) {
             if(agedc[i]>0)
               if((int)moisdc[i]!=99 && (int)andc[i]!=9999)
                 agev[m][i]=agedc[i];
             /*if(moisdc[i]==99 && andc[i]==9999) s[m][i]=-1;*/
               else {
                 if ((int)andc[i]!=9999){
                   nbwarn++;
                   printf("Warning negative age at death: %ld line:%d\n",num[i],i);
                   fprintf(ficlog,"Warning negative age at death: %ld line:%d\n",num[i],i);
                   agev[m][i]=-1;
                 }
               }
           }
           else if(s[m][i] !=9){ /* Standard case, age in fractional
                                    years but with the precision of a
                                    month */
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);
             if((int)mint[m][i]==99 || (int)anint[m][i]==9999)
               agev[m][i]=1;
             else if(agev[m][i] <agemin){ 
               agemin=agev[m][i];
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/
             }
             else if(agev[m][i] >agemax){
               agemax=agev[m][i];
               /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/
             }
             /*agev[m][i]=anint[m][i]-annais[i];*/
             /*     agev[m][i] = age[i]+2*m;*/
           }
           else { /* =9 */
             agev[m][i]=1;
             s[m][i]=-1;
           }
         }
         else /*= 0 Unknown */
           agev[m][i]=1;
       }
       
     }
     for (i=1; i<=imx; i++)  {
       for(m=firstpass; (m<=lastpass); m++){
         if (s[m][i] > (nlstate+ndeath)) {
           nberr++;
           printf("Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           fprintf(ficlog,"Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           goto end;
         }
       }
     }
   
     /*for (i=1; i<=imx; i++){
     for (m=firstpass; (m<lastpass); m++){
        printf("%ld %d %.lf %d %d\n", num[i],(covar[1][i]),agev[m][i],s[m][i],s[m+1][i]);
   }
   
   }*/
   
     printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);
     fprintf(ficlog,"Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax); 
   
     free_vector(severity,1,maxwav);
     free_imatrix(outcome,1,maxwav+1,1,n);
     free_vector(moisnais,1,n);
     free_vector(annais,1,n);
     /* free_matrix(mint,1,maxwav,1,n);
        free_matrix(anint,1,maxwav,1,n);*/
     free_vector(moisdc,1,n);
     free_vector(andc,1,n);
   
      
     wav=ivector(1,imx);
     dh=imatrix(1,lastpass-firstpass+1,1,imx);
     bh=imatrix(1,lastpass-firstpass+1,1,imx);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);
      
     /* Concatenates waves */
     concatwav(wav, dh, bh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);
   
     /* Routine tricode is to calculate cptcoveff (real number of unique covariates) and to associate covariable number and modality */
   
     Tcode=ivector(1,100);
     nbcode=imatrix(0,NCOVMAX,0,NCOVMAX); 
     ncodemax[1]=1;
     if (cptcovn > 0) tricode(Tvar,nbcode,imx);
         
     codtab=imatrix(1,100,1,10); /* Cross tabulation to get the order of 
                                    the estimations*/
     h=0;
     m=pow(2,cptcoveff);
    
     for(k=1;k<=cptcoveff; k++){
       for(i=1; i <=(m/pow(2,k));i++){
         for(j=1; j <= ncodemax[k]; j++){
           for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){
             h++;
             if (h>m) h=1;codtab[h][k]=j;codtab[h][Tvar[k]]=j;
             /*  printf("h=%d k=%d j=%d codtab[h][k]=%d tvar[k]=%d \n",h, k,j,codtab[h][k],Tvar[k]);*/
           } 
         }
       }
     } 
     /* printf("codtab[1][2]=%d codtab[2][2]=%d",codtab[1][2],codtab[2][2]); 
        codtab[1][2]=1;codtab[2][2]=2; */
     /* for(i=1; i <=m ;i++){ 
        for(k=1; k <=cptcovn; k++){
        printf("i=%d k=%d %d %d ",i,k,codtab[i][k], cptcoveff);
        }
        printf("\n");
        }
        scanf("%d",i);*/
       
     /*------------ gnuplot -------------*/
     strcpy(optionfilegnuplot,optionfilefiname);
     strcat(optionfilegnuplot,".gp");
     if((ficgp=fopen(optionfilegnuplot,"w"))==NULL) {
       printf("Problem with file %s",optionfilegnuplot);
     }
     else{
       fprintf(ficgp,"\n# %s\n", version); 
       fprintf(ficgp,"# %s\n", optionfilegnuplot); 
       fprintf(ficgp,"set missing 'NaNq'\n");
     }
     /*  fclose(ficgp);*/
     /*--------- index.htm --------*/
   
     strcpy(optionfilehtm,optionfilefiname); /* Main html file */
     strcat(optionfilehtm,".htm");
     if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtm), exit(0);
     }
   
     strcpy(optionfilehtmcov,optionfilefiname); /* Only for matrix of covariance */
     strcat(optionfilehtmcov,"-cov.htm");
     if((fichtmcov=fopen(optionfilehtmcov,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtmcov), exit(0);
     }
     else{
     fprintf(fichtmcov,"<body>\n<title>IMaCh Cov %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model);
     }
   
     fprintf(fichtm,"<body>\n<title>IMaCh %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n\
   \n\
   <hr  size=\"2\" color=\"#EC5E5E\">\
    <ul><li><h4>Parameter files</h4>\n\
    - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>\n\
    - Log file of the run: <a href=\"%s\">%s</a><br>\n\
    - Gnuplot file name: <a href=\"%s\">%s</a><br>\n\
    - Date and time at start: %s</ul>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model,\
             fileres,fileres,\
             filelog,filelog,optionfilegnuplot,optionfilegnuplot,strstart);
     fflush(fichtm);
   
     strcpy(pathr,path);
     strcat(pathr,optionfilefiname);
     chdir(optionfilefiname); /* Move to directory named optionfile */
     
     /* Calculates basic frequencies. Computes observed prevalence at single age
        and prints on file fileres'p'. */
     freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);
   
     fprintf(fichtm,"\n");
     fprintf(fichtm,"<br>Total number of observations=%d <br>\n\
   Youngest age at first (selected) pass %.2f, oldest age %.2f<br>\n\
   Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>\n",\
             imx,agemin,agemax,jmin,jmax,jmean);
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */
       
      
     /* For Powell, parameters are in a vector p[] starting at p[1]
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */
   
     globpr=0; /* To get the number ipmx of contributions and the sum of weights*/
     likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
     printf("First Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
     for (k=1; k<=npar;k++)
       printf(" %d %8.5f",k,p[k]);
     printf("\n");
     globpr=1; /* to print the contributions */
     likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
     printf("Second Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
     for (k=1; k<=npar;k++)
       printf(" %d %8.5f",k,p[k]);
     printf("\n");
     if(mle>=1){ /* Could be 1 or 2 */
       mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);
     }
       
     /*--------- results files --------------*/
     fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle= 0 weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate, ndeath, maxwav, weightopt,model);
     
   
     fprintf(ficres,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficlog,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           printf("%d%d ",i,k);
           fprintf(ficlog,"%d%d ",i,k);
           fprintf(ficres,"%1d%1d ",i,k);
           for(j=1; j <=ncovmodel; j++){
             printf("%f ",p[jk]);
             fprintf(ficlog,"%f ",p[jk]);
             fprintf(ficres,"%f ",p[jk]);
             jk++; 
           }
           printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficres,"\n");
         }
       }
     }
     if(mle!=0){
       /* Computing hessian and covariance matrix */
       ftolhess=ftol; /* Usually correct */
       hesscov(matcov, p, npar, delti, ftolhess, func);
     }
     fprintf(ficres,"# Scales (for hessian or gradient estimation)\n");
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficlog,"# Scales (for hessian or gradient estimation)\n");
     for(i=1,jk=1; i <=nlstate; i++){
       for(j=1; j <=nlstate+ndeath; j++){
         if (j!=i) {
           fprintf(ficres,"%1d%1d",i,j);
           printf("%1d%1d",i,j);
           fprintf(ficlog,"%1d%1d",i,j);
           for(k=1; k<=ncovmodel;k++){
             printf(" %.5e",delti[jk]);
             fprintf(ficlog," %.5e",delti[jk]);
             fprintf(ficres," %.5e",delti[jk]);
             jk++;
           }
           printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficres,"\n");
         }
       }
     }
      
     fprintf(ficres,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
     if(mle>=1)
       printf("# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
     fprintf(ficlog,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
   
   
   /* Just to have a covariance matrix which will be more understandable
      even is we still don't want to manage dictionary of variables
   */
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               if(mle>=1)
                 printf("#%1d%1d%d",i,j,k);
               fprintf(ficlog,"#%1d%1d%d",i,j,k);
               fprintf(ficres,"#%1d%1d%d",i,j,k);
             }else{
               if(mle>=1)
                 printf("%1d%1d%d",i,j,k);
               fprintf(ficlog,"%1d%1d%d",i,j,k);
               fprintf(ficres,"%1d%1d%d",i,j,k);
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         if(mle>=1)
                           printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficlog," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficres," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         if(mle>=1)
                           printf(" %.5e",matcov[jj][ll]); 
                         fprintf(ficlog," %.5e",matcov[jj][ll]); 
                         fprintf(ficres," %.5e",matcov[jj][ll]); 
                       }
                     }else{
                       if(itimes==1){
                         if(mle>=1)
                           printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficlog," Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficres," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         if(mle>=1)
                           printf(" %.5e",matcov[jj][ll]); 
                         fprintf(ficlog," %.5e",matcov[jj][ll]); 
                         fprintf(ficres," %.5e",matcov[jj][ll]); 
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             if(mle>=1)
               printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
     fflush(ficlog);
     fflush(ficres);
   
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       puts(line);
       fputs(line,ficparo);
     }
     ungetc(c,ficpar);
   
     estepm=0;
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf estepm=%d\n",&ageminpar,&agemaxpar, &bage, &fage, &estepm);
     if (estepm==0 || estepm < stepm) estepm=stepm;
     if (fage <= 2) {
       bage = ageminpar;
       fage = agemaxpar;
     }
      
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
     fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
      
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       puts(line);
       fputs(line,ficparo);
     }
     ungetc(c,ficpar);
     
     fscanf(ficpar,"begin-prev-date=%lf/%lf/%lf end-prev-date=%lf/%lf/%lf mov_average=%d\n",&jprev1, &mprev1,&anprev1,&jprev2, &mprev2,&anprev2,&mobilav);
     fprintf(ficparo,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
     fprintf(ficres,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
     printf("begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
     fprintf(ficlog,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
      
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       puts(line);
       fputs(line,ficparo);
     }
     ungetc(c,ficpar);
    
   
     dateprev1=anprev1+(mprev1-1)/12.+(jprev1-1)/365.;
     dateprev2=anprev2+(mprev2-1)/12.+(jprev2-1)/365.;
   
     fscanf(ficpar,"pop_based=%d\n",&popbased);
     fprintf(ficparo,"pop_based=%d\n",popbased);   
     fprintf(ficres,"pop_based=%d\n",popbased);   
     
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       puts(line);
       fputs(line,ficparo);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"prevforecast=%d starting-proj-date=%lf/%lf/%lf final-proj-date=%lf/%lf/%lf mobil_average=%d\n",&prevfcast,&jproj1,&mproj1,&anproj1,&jproj2,&mproj2,&anproj2,&mobilavproj);
     fprintf(ficparo,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
     printf("prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
     fprintf(ficlog,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
     fprintf(ficres,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
     /* day and month of proj2 are not used but only year anproj2.*/
   
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       puts(line);
       fputs(line,ficparo);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"popforecast=%d popfile=%s popfiledate=%lf/%lf/%lf last-popfiledate=%lf/%lf/%lf\n",&popforecast,popfile,&jpyram,&mpyram,&anpyram,&jpyram1,&mpyram1,&anpyram1);
     fprintf(ficparo,"popforecast=%d popfile=%s popfiledate=%.lf/%.lf/%.lf last-popfiledate=%.lf/%.lf/%.lf\n",popforecast,popfile,jpyram,mpyram,anpyram,jpyram1,mpyram1,anpyram1);
     fprintf(ficres,"popforecast=%d popfile=%s popfiledate=%.lf/%.lf/%.lf last-popfiledate=%.lf/%.lf/%.lf\n",popforecast,popfile,jpyram,mpyram,anpyram,jpyram1,mpyram1,anpyram1);
   
     /*  freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);*/
     /*,dateprev1,dateprev2,jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
   
     replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
     printinggnuplot(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
   
     printinghtml(fileres,title,datafile, firstpass, lastpass, stepm, weightopt,\
                  model,imx,jmin,jmax,jmean,rfileres,popforecast,estepm,\
                  jprev1,mprev1,anprev1,jprev2,mprev2,anprev2);
    
     /*------------ free_vector  -------------*/
     /*  chdir(path); */
    
     free_ivector(wav,1,imx);
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);
     free_imatrix(bh,1,lastpass-firstpass+1,1,imx);
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
     free_lvector(num,1,n);
     free_vector(agedc,1,n);
     /*free_matrix(covar,0,NCOVMAX,1,n);*/
     /*free_matrix(covar,1,NCOVMAX,1,n);*/
     fclose(ficparo);
     fclose(ficres);
   
   
     /*--------------- Prevalence limit  (stable prevalence) --------------*/
     
     strcpy(filerespl,"pl");
     strcat(filerespl,fileres);
     if((ficrespl=fopen(filerespl,"w"))==NULL) {
       printf("Problem with stable prevalence resultfile: %s\n", filerespl);goto end;
       fprintf(ficlog,"Problem with stable prevalence resultfile: %s\n", filerespl);goto end;
     }
     printf("Computing stable prevalence: result on file '%s' \n", filerespl);
     fprintf(ficlog,"Computing stable prevalence: result on file '%s' \n", filerespl);
     fprintf(ficrespl,"#Stable prevalence \n");
     fprintf(ficrespl,"#Age ");
     for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);
     fprintf(ficrespl,"\n");
     
     prlim=matrix(1,nlstate,1,nlstate);
   
     agebase=ageminpar;
     agelim=agemaxpar;
     ftolpl=1.e-10;
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
   
     for(cptcov=1,k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
         k=k+1;
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/
         fprintf(ficrespl,"\n#******");
         printf("\n#******");
         fprintf(ficlog,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           printf(" V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficlog," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespl,"******\n");
         printf("******\n");
         fprintf(ficlog,"******\n");
           
         for (age=agebase; age<=agelim; age++){
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
           fprintf(ficrespl,"%.0f ",age );
           for(j=1;j<=cptcoveff;j++)
             fprintf(ficrespl,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           for(i=1; i<=nlstate;i++)
             fprintf(ficrespl," %.5f", prlim[i][i]);
           fprintf(ficrespl,"\n");
         }
       }
     }
     fclose(ficrespl);
   
     /*------------- h Pij x at various ages ------------*/
     
     strcpy(filerespij,"pij");  strcat(filerespij,fileres);
     if((ficrespij=fopen(filerespij,"w"))==NULL) {
       printf("Problem with Pij resultfile: %s\n", filerespij);goto end;
       fprintf(ficlog,"Problem with Pij resultfile: %s\n", filerespij);goto end;
     }
     printf("Computing pij: result on file '%s' \n", filerespij);
     fprintf(ficlog,"Computing pij: result on file '%s' \n", filerespij);
     
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     /*if (stepm<=24) stepsize=2;*/
   
     agelim=AGESUP;
     hstepm=stepsize*YEARM; /* Every year of age */
     hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */ 
   
     /* hstepm=1;   aff par mois*/
   
     fprintf(ficrespij,"#****** h Pij x Probability to be in state j at age x+h being in i at x ");
     for(cptcov=1,k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
         k=k+1;
         fprintf(ficrespij,"\n#****** ");
         for(j=1;j<=cptcoveff;j++) 
           fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         fprintf(ficrespij,"******\n");
           
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
   
           /*        nhstepm=nhstepm*YEARM; aff par mois*/
   
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           oldm=oldms;savm=savms;
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           fprintf(ficrespij,"# Cov Agex agex+h hpijx with i,j=");
           for(i=1; i<=nlstate;i++)
             for(j=1; j<=nlstate+ndeath;j++)
               fprintf(ficrespij," %1d-%1d",i,j);
           fprintf(ficrespij,"\n");
           for (h=0; h<=nhstepm; h++){
             fprintf(ficrespij,"%d %3.f %3.f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );
             for(i=1; i<=nlstate;i++)
               for(j=1; j<=nlstate+ndeath;j++)
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);
             fprintf(ficrespij,"\n");
           }
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           fprintf(ficrespij,"\n");
         }
       }
     }
   
     varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax);
   
     fclose(ficrespij);
   
     probs= ma3x(1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     /*---------- Forecasting ------------------*/
     /*if((stepm == 1) && (strcmp(model,".")==0)){*/
     if(prevfcast==1){
       /*    if(stepm ==1){*/
         prevforecast(fileres, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff);
         /* (popforecast==1) populforecast(fileres, anpyram,mpyram,jpyram, agemin,agemax, dateprev1, dateprev2,mobilav, agedeb, fage, popforecast, popfile, anpyram1,p, i1);*/
   /*      }  */
   /*      else{ */
   /*        erreur=108; */
   /*        printf("Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
   /*        fprintf(ficlog,"Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
   /*      } */
     }
     
   
     /*---------- Health expectancies and variances ------------*/
   
     strcpy(filerest,"t");
     strcat(filerest,fileres);
     if((ficrest=fopen(filerest,"w"))==NULL) {
       printf("Problem with total LE resultfile: %s\n", filerest);goto end;
       fprintf(ficlog,"Problem with total LE resultfile: %s\n", filerest);goto end;
     }
     printf("Computing Total LEs with variances: file '%s' \n", filerest); 
     fprintf(ficlog,"Computing Total LEs with variances: file '%s' \n", filerest); 
   
   
     strcpy(filerese,"e");
     strcat(filerese,fileres);
     if((ficreseij=fopen(filerese,"w"))==NULL) {
       printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
       fprintf(ficlog,"Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
     }
     printf("Computing Health Expectancies: result on file '%s' \n", filerese);
     fprintf(ficlog,"Computing Health Expectancies: result on file '%s' \n", filerese);
   
     strcpy(fileresv,"v");
     strcat(fileresv,fileres);
     if((ficresvij=fopen(fileresv,"w"))==NULL) {
       printf("Problem with variance resultfile: %s\n", fileresv);exit(0);
       fprintf(ficlog,"Problem with variance resultfile: %s\n", fileresv);exit(0);
     }
     printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
     fprintf(ficlog,"Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
   
     /* Computes prevalence between agemin (i.e minimal age computed) and no more ageminpar */
     prevalence(probs, agemin, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     /*  printf("ageminpar=%f, agemax=%f, s[lastpass][imx]=%d, agev[lastpass][imx]=%f, nlstate=%d, imx=%d,  mint[lastpass][imx]=%f, anint[lastpass][imx]=%f,dateprev1=%f, dateprev2=%f, firstpass=%d, lastpass=%d\n",\
   ageminpar, agemax, s[lastpass][imx], agev[lastpass][imx], nlstate, imx, mint[lastpass][imx],anint[lastpass][imx], dateprev1, dateprev2, firstpass, lastpass);
     */
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     for(cptcov=1,k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
         k=k+1; 
         fprintf(ficrest,"\n#****** ");
         for(j=1;j<=cptcoveff;j++) 
           fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         fprintf(ficrest,"******\n");
   
         fprintf(ficreseij,"\n#****** ");
         for(j=1;j<=cptcoveff;j++) 
           fprintf(ficreseij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         fprintf(ficreseij,"******\n");
   
         fprintf(ficresvij,"\n#****** ");
         for(j=1;j<=cptcoveff;j++) 
           fprintf(ficresvij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         fprintf(ficresvij,"******\n");
   
         eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
         oldm=oldms;savm=savms;
         evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, delti, matcov);  
    
         vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
         oldm=oldms;savm=savms;
         varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,0, mobilav);
         if(popbased==1){
           varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,popbased,mobilav);
         }
   
    
         fprintf(ficrest,"#Total LEs with variances: e.. (std) ");
         for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);
         fprintf(ficrest,"\n");
   
         epj=vector(1,nlstate+1);
         for(age=bage; age <=fage ;age++){
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
           if (popbased==1) {
             if(mobilav ==0){
               for(i=1; i<=nlstate;i++)
                 prlim[i][i]=probs[(int)age][i][k];
             }else{ /* mobilav */ 
               for(i=1; i<=nlstate;i++)
                 prlim[i][i]=mobaverage[(int)age][i][k];
             }
           }
           
           fprintf(ficrest," %4.0f",age);
           for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){
             for(i=1, epj[j]=0.;i <=nlstate;i++) {
               epj[j] += prlim[i][i]*eij[i][j][(int)age];
               /*  printf("%lf %lf ", prlim[i][i] ,eij[i][j][(int)age]);*/
             }
             epj[nlstate+1] +=epj[j];
           }
   
           for(i=1, vepp=0.;i <=nlstate;i++)
             for(j=1;j <=nlstate;j++)
               vepp += vareij[i][j][(int)age];
           fprintf(ficrest," %7.3f (%7.3f)", epj[nlstate+1],sqrt(vepp));
           for(j=1;j <=nlstate;j++){
             fprintf(ficrest," %7.3f (%7.3f)", epj[j],sqrt(vareij[j][j][(int)age]));
           }
           fprintf(ficrest,"\n");
         }
         free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
         free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);
         free_vector(epj,1,nlstate+1);
       }
     }
     free_vector(weight,1,n);
     free_imatrix(Tvard,1,15,1,2);
     free_imatrix(s,1,maxwav+1,1,n);
     free_matrix(anint,1,maxwav,1,n); 
     free_matrix(mint,1,maxwav,1,n);
     free_ivector(cod,1,n);
     free_ivector(tab,1,NCOVMAX);
     fclose(ficreseij);
     fclose(ficresvij);
     fclose(ficrest);
     fclose(ficpar);
     
     /*------- Variance of stable prevalence------*/   
   
     strcpy(fileresvpl,"vpl");
     strcat(fileresvpl,fileres);
     if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {
       printf("Problem with variance of stable prevalence  resultfile: %s\n", fileresvpl);
       exit(0);
     }
     printf("Computing Variance-covariance of stable prevalence: file '%s' \n", fileresvpl);
   
     for(cptcov=1,k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
         k=k+1;
         fprintf(ficresvpl,"\n#****** ");
         for(j=1;j<=cptcoveff;j++) 
           fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         fprintf(ficresvpl,"******\n");
         
         varpl=matrix(1,nlstate,(int) bage, (int) fage);
         oldm=oldms;savm=savms;
         varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);
         free_matrix(varpl,1,nlstate,(int) bage, (int)fage);
       }
     }
   
     fclose(ficresvpl);
   
     /*---------- End : free ----------------*/
     free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);
     free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);
     free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);
     free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);
     
     free_matrix(covar,0,NCOVMAX,1,n);
     free_matrix(matcov,1,npar,1,npar);
     /*free_vector(delti,1,npar);*/
     free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
     free_matrix(agev,1,maxwav,1,imx);
     free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(probs,1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     free_ivector(ncodemax,1,8);
     free_ivector(Tvar,1,15);
     free_ivector(Tprod,1,15);
     free_ivector(Tvaraff,1,15);
     free_ivector(Tage,1,15);
     free_ivector(Tcode,1,100);
   
     fflush(fichtm);
     fflush(ficgp);
     
   
     if((nberr >0) || (nbwarn>0)){
       printf("End of Imach with %d errors and/or %d warnings\n",nberr,nbwarn);
       fprintf(ficlog,"End of Imach with %d errors and/or warnings %d\n",nberr,nbwarn);
     }else{
       printf("End of Imach\n");
       fprintf(ficlog,"End of Imach\n");
     }
     printf("See log file on %s\n",filelog);
     /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */
     (void) gettimeofday(&end_time,&tzp);
     tm = *localtime(&end_time.tv_sec);
     tmg = *gmtime(&end_time.tv_sec);
     strcpy(strtend,asctime(&tm));
     printf("Local time at start %s\nLocaltime at end   %s",strstart, strtend); 
     fprintf(ficlog,"Local time at start %s\nLocal time at end   %s\n",strstart, strtend); 
     printf("Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
   
     printf("Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     fprintf(ficlog,"Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
     fprintf(ficlog,"Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     /*  printf("Total time was %d uSec.\n", total_usecs);*/
   /*   if(fileappend(fichtm,optionfilehtm)){ */
     fprintf(fichtm,"<br>Local time at start %s<br>Local time at end   %s<br>",strstart, strtend);
     fclose(fichtm);
     fclose(fichtmcov);
     fclose(ficgp);
     fclose(ficlog);
     /*------ End -----------*/
   
     chdir(path);
     strcpy(plotcmd,GNUPLOTPROGRAM);
     strcat(plotcmd," ");
     strcat(plotcmd,optionfilegnuplot);
     printf("Starting graphs with: %s",plotcmd);fflush(stdout);
     if((outcmd=system(plotcmd)) != 0){
       printf(" Problem with gnuplot\n");
     }
     printf(" Wait...");
     while (z[0] != 'q') {
       /* chdir(path); */
       printf("\nType e to edit output files, g to graph again and q for exiting: ");
       scanf("%s",z);
   /*     if (z[0] == 'c') system("./imach"); */
       if (z[0] == 'e') system(optionfilehtm);
       else if (z[0] == 'g') system(plotcmd);
       else if (z[0] == 'q') exit(0);
     }
     end:
     while (z[0] != 'q') {
       printf("\nType  q for exiting: ");
       scanf("%s",z);
     }
   }
   
   
   

Removed from v.1.5  
changed lines
  Added in v.1.95


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