Diff for /imach/src/imach.c between versions 1.7 and 1.118

version 1.7, 2001/05/02 17:50:24 version 1.118, 2006/03/14 18:20:07
Line 1 Line 1
      /* $Id$
 /*********************** Imach **************************************            $State$
   This program computes Healthy Life Expectancies from cross-longitudinal    $Log$
   data. Cross-longitudinal consist in a first survey ("cross") where    Revision 1.118  2006/03/14 18:20:07  brouard
   individuals from different ages are interviewed on their health status    (Module): varevsij Comments added explaining the second
   or degree of  disability. At least a second wave of interviews    table of variances if popbased=1 .
   ("longitudinal") should  measure each new individual health status.    (Module): Covariances of eij, ekl added, graphs fixed, new html link.
   Health expectancies are computed from the transistions observed between    (Module): Function pstamp added
   waves and are computed for each degree of severity of disability (number    (Module): Version 0.98d
   of life states). More degrees you consider, more time is necessary to  
   reach the Maximum Likelihood of the parameters involved in the model.    Revision 1.117  2006/03/14 17:16:22  brouard
   The simplest model is the multinomial logistic model where pij is    (Module): varevsij Comments added explaining the second
   the probabibility to be observed in state j at the second wave conditional    table of variances if popbased=1 .
   to be observed in state i at the first wave. Therefore the model is:    (Module): Covariances of eij, ekl added, graphs fixed, new html link.
   log(pij/pii)= aij + bij*age+ cij*sex + etc , where 'age' is age and 'sex'    (Module): Function pstamp added
   is a covariate. If you want to have a more complex model than "constant and    (Module): Version 0.98d
   age", you should modify the program where the markup  
     *Covariates have to be included here again* invites you to do it.    Revision 1.116  2006/03/06 10:29:27  brouard
   More covariates you add, less is the speed of the convergence.    (Module): Variance-covariance wrong links and
     varian-covariance of ej. is needed (Saito).
   The advantage that this computer programme claims, comes from that if the  
   delay between waves is not identical for each individual, or if some    Revision 1.115  2006/02/27 12:17:45  brouard
   individual missed an interview, the information is not rounded or lost, but    (Module): One freematrix added in mlikeli! 0.98c
   taken into account using an interpolation or extrapolation.  
   hPijx is the probability to be    Revision 1.114  2006/02/26 12:57:58  brouard
   observed in state i at age x+h conditional to the observed state i at age    (Module): Some improvements in processing parameter
   x. The delay 'h' can be split into an exact number (nh*stepm) of    filename with strsep.
   unobserved intermediate  states. This elementary transition (by month or  
   quarter trimester, semester or year) is model as a multinomial logistic.    Revision 1.113  2006/02/24 14:20:24  brouard
   The hPx matrix is simply the matrix product of nh*stepm elementary matrices    (Module): Memory leaks checks with valgrind and:
   and the contribution of each individual to the likelihood is simply hPijx.    datafile was not closed, some imatrix were not freed and on matrix
     allocation too.
   Also this programme outputs the covariance matrix of the parameters but also  
   of the life expectancies. It also computes the prevalence limits.    Revision 1.112  2006/01/30 09:55:26  brouard
      (Module): Back to gnuplot.exe instead of wgnuplot.exe
   Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).  
            Institut national d'études démographiques, Paris.    Revision 1.111  2006/01/25 20:38:18  brouard
   This software have been partly granted by Euro-REVES, a concerted action    (Module): Lots of cleaning and bugs added (Gompertz)
   from the European Union.    (Module): Comments can be added in data file. Missing date values
   It is copyrighted identically to a GNU software product, ie programme and    can be a simple dot '.'.
   software can be distributed freely for non commercial use. Latest version  
   can be accessed at http://euroreves.ined.fr/imach .    Revision 1.110  2006/01/25 00:51:50  brouard
   **********************************************************************/    (Module): Lots of cleaning and bugs added (Gompertz)
    
 #include <math.h>    Revision 1.109  2006/01/24 19:37:15  brouard
 #include <stdio.h>    (Module): Comments (lines starting with a #) are allowed in data.
 #include <stdlib.h>  
 #include <unistd.h>    Revision 1.108  2006/01/19 18:05:42  lievre
     Gnuplot problem appeared...
 #define MAXLINE 256    To be fixed
 #define FILENAMELENGTH 80  
 /*#define DEBUG*/    Revision 1.107  2006/01/19 16:20:37  brouard
 #define windows    Test existence of gnuplot in imach path
 #define GLOCK_ERROR_NOPATH              -1      /* empty path */  
 #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */    Revision 1.106  2006/01/19 13:24:36  brouard
     Some cleaning and links added in html output
 #define MAXPARM 30 /* Maximum number of parameters for the optimization */  
 #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */    Revision 1.105  2006/01/05 20:23:19  lievre
     *** empty log message ***
 #define NINTERVMAX 8  
 #define NLSTATEMAX 8 /* Maximum number of live states (for func) */    Revision 1.104  2005/09/30 16:11:43  lievre
 #define NDEATHMAX 8 /* Maximum number of dead states (for func) */    (Module): sump fixed, loop imx fixed, and simplifications.
 #define NCOVMAX 8 /* Maximum number of covariates */    (Module): If the status is missing at the last wave but we know
 #define MAXN 20000    that the person is alive, then we can code his/her status as -2
 #define YEARM 12. /* Number of months per year */    (instead of missing=-1 in earlier versions) and his/her
 #define AGESUP 130    contributions to the likelihood is 1 - Prob of dying from last
 #define AGEBASE 40    health status (= 1-p13= p11+p12 in the easiest case of somebody in
     the healthy state at last known wave). Version is 0.98
   
 int nvar;    Revision 1.103  2005/09/30 15:54:49  lievre
 static int cptcov;    (Module): sump fixed, loop imx fixed, and simplifications.
 int cptcovn, cptcovage=0, cptcoveff=0;  
 int npar=NPARMAX;    Revision 1.102  2004/09/15 17:31:30  brouard
 int nlstate=2; /* Number of live states */    Add the possibility to read data file including tab characters.
 int ndeath=1; /* Number of dead states */  
 int ncovmodel, ncov;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */    Revision 1.101  2004/09/15 10:38:38  brouard
     Fix on curr_time
 int *wav; /* Number of waves for this individuual 0 is possible */  
 int maxwav; /* Maxim number of waves */    Revision 1.100  2004/07/12 18:29:06  brouard
 int mle, weightopt;    Add version for Mac OS X. Just define UNIX in Makefile
 int **mw; /* mw[mi][i] is number of the mi wave for this individual */  
 int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */    Revision 1.99  2004/06/05 08:57:40  brouard
 double **oldm, **newm, **savm; /* Working pointers to matrices */    *** empty log message ***
 double **oldms, **newms, **savms; /* Fixed working pointers to matrices */  
 FILE *fic,*ficpar, *ficparo,*ficres,  *ficrespl, *ficrespij, *ficrest;    Revision 1.98  2004/05/16 15:05:56  brouard
 FILE *ficgp, *fichtm;    New version 0.97 . First attempt to estimate force of mortality
 FILE *ficreseij;    directly from the data i.e. without the need of knowing the health
   char filerese[FILENAMELENGTH];    state at each age, but using a Gompertz model: log u =a + b*age .
  FILE  *ficresvij;    This is the basic analysis of mortality and should be done before any
   char fileresv[FILENAMELENGTH];    other analysis, in order to test if the mortality estimated from the
  FILE  *ficresvpl;    cross-longitudinal survey is different from the mortality estimated
   char fileresvpl[FILENAMELENGTH];    from other sources like vital statistic data.
   
 #define NR_END 1    The same imach parameter file can be used but the option for mle should be -3.
 #define FREE_ARG char*  
 #define FTOL 1.0e-10    Agnès, who wrote this part of the code, tried to keep most of the
     former routines in order to include the new code within the former code.
 #define NRANSI  
 #define ITMAX 200    The output is very simple: only an estimate of the intercept and of
     the slope with 95% confident intervals.
 #define TOL 2.0e-4  
     Current limitations:
 #define CGOLD 0.3819660    A) Even if you enter covariates, i.e. with the
 #define ZEPS 1.0e-10    model= V1+V2 equation for example, the programm does only estimate a unique global model without covariates.
 #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d);    B) There is no computation of Life Expectancy nor Life Table.
   
 #define GOLD 1.618034    Revision 1.97  2004/02/20 13:25:42  lievre
 #define GLIMIT 100.0    Version 0.96d. Population forecasting command line is (temporarily)
 #define TINY 1.0e-20    suppressed.
   
 static double maxarg1,maxarg2;    Revision 1.96  2003/07/15 15:38:55  brouard
 #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))    * imach.c (Repository): Errors in subdirf, 2, 3 while printing tmpout is
 #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))    rewritten within the same printf. Workaround: many printfs.
    
 #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))    Revision 1.95  2003/07/08 07:54:34  brouard
 #define rint(a) floor(a+0.5)    * imach.c (Repository):
     (Repository): Using imachwizard code to output a more meaningful covariance
 static double sqrarg;    matrix (cov(a12,c31) instead of numbers.
 #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)  
 #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;}    Revision 1.94  2003/06/27 13:00:02  brouard
     Just cleaning
 int imx;  
 int stepm;    Revision 1.93  2003/06/25 16:33:55  brouard
 /* Stepm, step in month: minimum step interpolation*/    (Module): On windows (cygwin) function asctime_r doesn't
     exist so I changed back to asctime which exists.
 int m,nb;    (Module): Version 0.96b
 int *num, firstpass=0, lastpass=4,*cod, *ncodemax, *Tage;  
 double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;    Revision 1.92  2003/06/25 16:30:45  brouard
 double **pmmij;    (Module): On windows (cygwin) function asctime_r doesn't
     exist so I changed back to asctime which exists.
 double *weight;  
 int **s; /* Status */    Revision 1.91  2003/06/25 15:30:29  brouard
 double *agedc, **covar, idx;    * imach.c (Repository): Duplicated warning errors corrected.
 int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;    (Repository): Elapsed time after each iteration is now output. It
     helps to forecast when convergence will be reached. Elapsed time
 double ftol=FTOL; /* Tolerance for computing Max Likelihood */    is stamped in powell.  We created a new html file for the graphs
 double ftolhess; /* Tolerance for computing hessian */    concerning matrix of covariance. It has extension -cov.htm.
   
 /**************** split *************************/    Revision 1.90  2003/06/24 12:34:15  brouard
 static  int split( char *path, char *dirc, char *name )    (Module): Some bugs corrected for windows. Also, when
 {    mle=-1 a template is output in file "or"mypar.txt with the design
    char *s;                             /* pointer */    of the covariance matrix to be input.
    int  l1, l2;                         /* length counters */  
     Revision 1.89  2003/06/24 12:30:52  brouard
    l1 = strlen( path );                 /* length of path */    (Module): Some bugs corrected for windows. Also, when
    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );    mle=-1 a template is output in file "or"mypar.txt with the design
    s = strrchr( path, '\\' );           /* find last / */    of the covariance matrix to be input.
    if ( s == NULL ) {                   /* no directory, so use current */  
 #if     defined(__bsd__)                /* get current working directory */    Revision 1.88  2003/06/23 17:54:56  brouard
       extern char       *getwd( );    * imach.c (Repository): Create a sub-directory where all the secondary files are. Only imach, htm, gp and r(imach) are on the main directory. Correct time and other things.
   
       if ( getwd( dirc ) == NULL ) {    Revision 1.87  2003/06/18 12:26:01  brouard
 #else    Version 0.96
       extern char       *getcwd( );  
     Revision 1.86  2003/06/17 20:04:08  brouard
       if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {    (Module): Change position of html and gnuplot routines and added
 #endif    routine fileappend.
          return( GLOCK_ERROR_GETCWD );  
       }    Revision 1.85  2003/06/17 13:12:43  brouard
       strcpy( name, path );             /* we've got it */    * imach.c (Repository): Check when date of death was earlier that
    } else {                             /* strip direcotry from path */    current date of interview. It may happen when the death was just
       s++;                              /* after this, the filename */    prior to the death. In this case, dh was negative and likelihood
       l2 = strlen( s );                 /* length of filename */    was wrong (infinity). We still send an "Error" but patch by
       if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );    assuming that the date of death was just one stepm after the
       strcpy( name, s );                /* save file name */    interview.
       strncpy( dirc, path, l1 - l2 );   /* now the directory */    (Repository): Because some people have very long ID (first column)
       dirc[l1-l2] = 0;                  /* add zero */    we changed int to long in num[] and we added a new lvector for
    }    memory allocation. But we also truncated to 8 characters (left
    l1 = strlen( dirc );                 /* length of directory */    truncation)
    if ( dirc[l1-1] != '\\' ) { dirc[l1] = '\\'; dirc[l1+1] = 0; }    (Repository): No more line truncation errors.
    return( 0 );                         /* we're done */  
 }    Revision 1.84  2003/06/13 21:44:43  brouard
     * imach.c (Repository): Replace "freqsummary" at a correct
     place. It differs from routine "prevalence" which may be called
 /******************************************/    many times. Probs is memory consuming and must be used with
     parcimony.
 void replace(char *s, char*t)    Version 0.95a3 (should output exactly the same maximization than 0.8a2)
 {  
   int i;    Revision 1.83  2003/06/10 13:39:11  lievre
   int lg=20;    *** empty log message ***
   i=0;  
   lg=strlen(t);    Revision 1.82  2003/06/05 15:57:20  brouard
   for(i=0; i<= lg; i++) {    Add log in  imach.c and  fullversion number is now printed.
     (s[i] = t[i]);  
     if (t[i]== '\\') s[i]='/';  */
   }  /*
 }     Interpolated Markov Chain
   
 int nbocc(char *s, char occ)    Short summary of the programme:
 {    
   int i,j=0;    This program computes Healthy Life Expectancies from
   int lg=20;    cross-longitudinal data. Cross-longitudinal data consist in: -1- a
   i=0;    first survey ("cross") where individuals from different ages are
   lg=strlen(s);    interviewed on their health status or degree of disability (in the
   for(i=0; i<= lg; i++) {    case of a health survey which is our main interest) -2- at least a
   if  (s[i] == occ ) j++;    second wave of interviews ("longitudinal") which measure each change
   }    (if any) in individual health status.  Health expectancies are
   return j;    computed from the time spent in each health state according to a
 }    model. More health states you consider, more time is necessary to reach the
     Maximum Likelihood of the parameters involved in the model.  The
 void cutv(char *u,char *v, char*t, char occ)    simplest model is the multinomial logistic model where pij is the
 {    probability to be observed in state j at the second wave
   int i,lg,j,p=0;    conditional to be observed in state i at the first wave. Therefore
   i=0;    the model is: log(pij/pii)= aij + bij*age+ cij*sex + etc , where
   for(j=0; j<=strlen(t)-1; j++) {    'age' is age and 'sex' is a covariate. If you want to have a more
     if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;    complex model than "constant and age", you should modify the program
   }    where the markup *Covariates have to be included here again* invites
     you to do it.  More covariates you add, slower the
   lg=strlen(t);    convergence.
   for(j=0; j<p; j++) {  
     (u[j] = t[j]);    The advantage of this computer programme, compared to a simple
   }    multinomial logistic model, is clear when the delay between waves is not
      u[p]='\0';    identical for each individual. Also, if a individual missed an
     intermediate interview, the information is lost, but taken into
    for(j=0; j<= lg; j++) {    account using an interpolation or extrapolation.  
     if (j>=(p+1))(v[j-p-1] = t[j]);  
   }    hPijx is the probability to be observed in state i at age x+h
 }    conditional to the observed state i at age x. The delay 'h' can be
     split into an exact number (nh*stepm) of unobserved intermediate
 /********************** nrerror ********************/    states. This elementary transition (by month, quarter,
     semester or year) is modelled as a multinomial logistic.  The hPx
 void nrerror(char error_text[])    matrix is simply the matrix product of nh*stepm elementary matrices
 {    and the contribution of each individual to the likelihood is simply
   fprintf(stderr,"ERREUR ...\n");    hPijx.
   fprintf(stderr,"%s\n",error_text);  
   exit(1);    Also this programme outputs the covariance matrix of the parameters but also
 }    of the life expectancies. It also computes the period (stable) prevalence. 
 /*********************** vector *******************/    
 double *vector(int nl, int nh)    Authors: Nicolas Brouard (brouard@ined.fr) and Agnès Lièvre (lievre@ined.fr).
 {             Institut national d'études démographiques, Paris.
   double *v;    This software have been partly granted by Euro-REVES, a concerted action
   v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));    from the European Union.
   if (!v) nrerror("allocation failure in vector");    It is copyrighted identically to a GNU software product, ie programme and
   return v-nl+NR_END;    software can be distributed freely for non commercial use. Latest version
 }    can be accessed at http://euroreves.ined.fr/imach .
   
 /************************ free vector ******************/    Help to debug: LD_PRELOAD=/usr/local/lib/libnjamd.so ./imach foo.imach
 void free_vector(double*v, int nl, int nh)    or better on gdb : set env LD_PRELOAD=/usr/local/lib/libnjamd.so
 {    
   free((FREE_ARG)(v+nl-NR_END));    **********************************************************************/
 }  /*
     main
 /************************ivector *******************************/    read parameterfile
 int *ivector(long nl,long nh)    read datafile
 {    concatwav
   int *v;    freqsummary
   v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));    if (mle >= 1)
   if (!v) nrerror("allocation failure in ivector");      mlikeli
   return v-nl+NR_END;    print results files
 }    if mle==1 
        computes hessian
 /******************free ivector **************************/    read end of parameter file: agemin, agemax, bage, fage, estepm
 void free_ivector(int *v, long nl, long nh)        begin-prev-date,...
 {    open gnuplot file
   free((FREE_ARG)(v+nl-NR_END));    open html file
 }    period (stable) prevalence
      for age prevalim()
 /******************* imatrix *******************************/    h Pij x
 int **imatrix(long nrl, long nrh, long ncl, long nch)    variance of p varprob
      /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */    forecasting if prevfcast==1 prevforecast call prevalence()
 {    health expectancies
   long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;    Variance-covariance of DFLE
   int **m;    prevalence()
       movingaverage()
   /* allocate pointers to rows */    varevsij() 
   m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*)));    if popbased==1 varevsij(,popbased)
   if (!m) nrerror("allocation failure 1 in matrix()");    total life expectancies
   m += NR_END;    Variance of period (stable) prevalence
   m -= nrl;   end
    */
    
   /* allocate rows and set pointers to them */  
   m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int)));  
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");   
   m[nrl] += NR_END;  #include <math.h>
   m[nrl] -= ncl;  #include <stdio.h>
    #include <stdlib.h>
   for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;  #include <string.h>
    #include <unistd.h>
   /* return pointer to array of pointers to rows */  
   return m;  #include <limits.h>
 }  #include <sys/types.h>
   #include <sys/stat.h>
 /****************** free_imatrix *************************/  #include <errno.h>
 void free_imatrix(m,nrl,nrh,ncl,nch)  extern int errno;
       int **m;  
       long nch,ncl,nrh,nrl;  /* #include <sys/time.h> */
      /* free an int matrix allocated by imatrix() */  #include <time.h>
 {  #include "timeval.h"
   free((FREE_ARG) (m[nrl]+ncl-NR_END));  
   free((FREE_ARG) (m+nrl-NR_END));  /* #include <libintl.h> */
 }  /* #define _(String) gettext (String) */
   
 /******************* matrix *******************************/  #define MAXLINE 256
 double **matrix(long nrl, long nrh, long ncl, long nch)  
 {  #define GNUPLOTPROGRAM "gnuplot"
   long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;  /*#define GNUPLOTPROGRAM "..\\gp37mgw\\wgnuplot"*/
   double **m;  #define FILENAMELENGTH 132
   
   m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  #define GLOCK_ERROR_NOPATH              -1      /* empty path */
   if (!m) nrerror("allocation failure 1 in matrix()");  #define GLOCK_ERROR_GETCWD              -2      /* cannot get cwd */
   m += NR_END;  
   m -= nrl;  #define MAXPARM 30 /* Maximum number of parameters for the optimization */
   #define NPARMAX 64 /* (nlstate+ndeath-1)*nlstate*ncovmodel */
   m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  #define NINTERVMAX 8
   m[nrl] += NR_END;  #define NLSTATEMAX 8 /* Maximum number of live states (for func) */
   m[nrl] -= ncl;  #define NDEATHMAX 8 /* Maximum number of dead states (for func) */
   #define NCOVMAX 8 /* Maximum number of covariates */
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  #define MAXN 20000
   return m;  #define YEARM 12. /* Number of months per year */
 }  #define AGESUP 130
   #define AGEBASE 40
 /*************************free matrix ************************/  #define AGEGOMP 10. /* Minimal age for Gompertz adjustment */
 void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)  #ifdef UNIX
 {  #define DIRSEPARATOR '/'
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  #define CHARSEPARATOR "/"
   free((FREE_ARG)(m+nrl-NR_END));  #define ODIRSEPARATOR '\\'
 }  #else
   #define DIRSEPARATOR '\\'
 /******************* ma3x *******************************/  #define CHARSEPARATOR "\\"
 double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)  #define ODIRSEPARATOR '/'
 {  #endif
   long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;  
   double ***m;  /* $Id$ */
   /* $State$ */
   m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));  
   if (!m) nrerror("allocation failure 1 in matrix()");  char version[]="Imach version 0.98d, March 2006, INED-EUROREVES-Institut de longevite ";
   m += NR_END;  char fullversion[]="$Revision$ $Date$"; 
   m -= nrl;  char strstart[80];
   char optionfilext[10], optionfilefiname[FILENAMELENGTH];
   m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));  int erreur, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings  */
   if (!m[nrl]) nrerror("allocation failure 2 in matrix()");  int nvar;
   m[nrl] += NR_END;  int cptcovn=0, cptcovage=0, cptcoveff=0,cptcov;
   m[nrl] -= ncl;  int npar=NPARMAX;
   int nlstate=2; /* Number of live states */
   for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;  int ndeath=1; /* Number of dead states */
   int ncovmodel, ncovcol;     /* Total number of covariables including constant a12*1 +b12*x ncovmodel=2 */
   m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));  int popbased=0;
   if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");  
   m[nrl][ncl] += NR_END;  int *wav; /* Number of waves for this individuual 0 is possible */
   m[nrl][ncl] -= nll;  int maxwav; /* Maxim number of waves */
   for (j=ncl+1; j<=nch; j++)  int jmin, jmax; /* min, max spacing between 2 waves */
     m[nrl][j]=m[nrl][j-1]+nlay;  int ijmin, ijmax; /* Individuals having jmin and jmax */ 
    int gipmx, gsw; /* Global variables on the number of contributions 
   for (i=nrl+1; i<=nrh; i++) {                     to the likelihood and the sum of weights (done by funcone)*/
     m[i][ncl]=m[i-1l][ncl]+ncol*nlay;  int mle, weightopt;
     for (j=ncl+1; j<=nch; j++)  int **mw; /* mw[mi][i] is number of the mi wave for this individual */
       m[i][j]=m[i][j-1]+nlay;  int **dh; /* dh[mi][i] is number of steps between mi,mi+1 for this individual */
   }  int **bh; /* bh[mi][i] is the bias (+ or -) for this individual if the delay between
   return m;             * wave mi and wave mi+1 is not an exact multiple of stepm. */
 }  double jmean; /* Mean space between 2 waves */
   double **oldm, **newm, **savm; /* Working pointers to matrices */
 /*************************free ma3x ************************/  double **oldms, **newms, **savms; /* Fixed working pointers to matrices */
 void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)  FILE *fic,*ficpar, *ficparo,*ficres, *ficresp, *ficrespl, *ficrespij, *ficrest,*ficresf,*ficrespop;
 {  FILE *ficlog, *ficrespow;
   free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));  int globpr; /* Global variable for printing or not */
   free((FREE_ARG)(m[nrl]+ncl-NR_END));  double fretone; /* Only one call to likelihood */
   free((FREE_ARG)(m+nrl-NR_END));  long ipmx; /* Number of contributions */
 }  double sw; /* Sum of weights */
   char filerespow[FILENAMELENGTH];
 /***************** f1dim *************************/  char fileresilk[FILENAMELENGTH]; /* File of individual contributions to the likelihood */
 extern int ncom;  FILE *ficresilk;
 extern double *pcom,*xicom;  FILE *ficgp,*ficresprob,*ficpop, *ficresprobcov, *ficresprobcor;
 extern double (*nrfunc)(double []);  FILE *ficresprobmorprev;
    FILE *fichtm, *fichtmcov; /* Html File */
 double f1dim(double x)  FILE *ficreseij;
 {  char filerese[FILENAMELENGTH];
   int j;  FILE *ficresstdeij;
   double f;  char fileresstde[FILENAMELENGTH];
   double *xt;  FILE *ficrescveij;
    char filerescve[FILENAMELENGTH];
   xt=vector(1,ncom);  FILE  *ficresvij;
   for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j];  char fileresv[FILENAMELENGTH];
   f=(*nrfunc)(xt);  FILE  *ficresvpl;
   free_vector(xt,1,ncom);  char fileresvpl[FILENAMELENGTH];
   return f;  char title[MAXLINE];
 }  char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];
   char plotcmd[FILENAMELENGTH], pplotcmd[FILENAMELENGTH];
 /*****************brent *************************/  char tmpout[FILENAMELENGTH],  tmpout2[FILENAMELENGTH]; 
 double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin)  char command[FILENAMELENGTH];
 {  int  outcmd=0;
   int iter;  
   double a,b,d,etemp;  char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH], rfileres[FILENAMELENGTH];
   double fu,fv,fw,fx;  
   double ftemp;  char filelog[FILENAMELENGTH]; /* Log file */
   double p,q,r,tol1,tol2,u,v,w,x,xm;  char filerest[FILENAMELENGTH];
   double e=0.0;  char fileregp[FILENAMELENGTH];
    char popfile[FILENAMELENGTH];
   a=(ax < cx ? ax : cx);  
   b=(ax > cx ? ax : cx);  char optionfilegnuplot[FILENAMELENGTH], optionfilehtm[FILENAMELENGTH], optionfilehtmcov[FILENAMELENGTH] ;
   x=w=v=bx;  
   fw=fv=fx=(*f)(x);  struct timeval start_time, end_time, curr_time, last_time, forecast_time;
   for (iter=1;iter<=ITMAX;iter++) {  struct timezone tzp;
     xm=0.5*(a+b);  extern int gettimeofday();
     tol2=2.0*(tol1=tol*fabs(x)+ZEPS);  struct tm tmg, tm, tmf, *gmtime(), *localtime();
     /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/  long time_value;
     printf(".");fflush(stdout);  extern long time();
 #ifdef DEBUG  char strcurr[80], strfor[80];
     printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);  
     /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */  char *endptr;
 #endif  long lval;
     if (fabs(x-xm) <= (tol2-0.5*(b-a))){  
       *xmin=x;  #define NR_END 1
       return fx;  #define FREE_ARG char*
     }  #define FTOL 1.0e-10
     ftemp=fu;  
     if (fabs(e) > tol1) {  #define NRANSI 
       r=(x-w)*(fx-fv);  #define ITMAX 200 
       q=(x-v)*(fx-fw);  
       p=(x-v)*q-(x-w)*r;  #define TOL 2.0e-4 
       q=2.0*(q-r);  
       if (q > 0.0) p = -p;  #define CGOLD 0.3819660 
       q=fabs(q);  #define ZEPS 1.0e-10 
       etemp=e;  #define SHFT(a,b,c,d) (a)=(b);(b)=(c);(c)=(d); 
       e=d;  
       if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x))  #define GOLD 1.618034 
         d=CGOLD*(e=(x >= xm ? a-x : b-x));  #define GLIMIT 100.0 
       else {  #define TINY 1.0e-20 
         d=p/q;  
         u=x+d;  static double maxarg1,maxarg2;
         if (u-a < tol2 || b-u < tol2)  #define FMAX(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)>(maxarg2)? (maxarg1):(maxarg2))
           d=SIGN(tol1,xm-x);  #define FMIN(a,b) (maxarg1=(a),maxarg2=(b),(maxarg1)<(maxarg2)? (maxarg1):(maxarg2))
       }    
     } else {  #define SIGN(a,b) ((b)>0.0 ? fabs(a) : -fabs(a))
       d=CGOLD*(e=(x >= xm ? a-x : b-x));  #define rint(a) floor(a+0.5)
     }  
     u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d));  static double sqrarg;
     fu=(*f)(u);  #define SQR(a) ((sqrarg=(a)) == 0.0 ? 0.0 :sqrarg*sqrarg)
     if (fu <= fx) {  #define SWAP(a,b) {temp=(a);(a)=(b);(b)=temp;} 
       if (u >= x) a=x; else b=x;  int agegomp= AGEGOMP;
       SHFT(v,w,x,u)  
         SHFT(fv,fw,fx,fu)  int imx; 
         } else {  int stepm=1;
           if (u < x) a=u; else b=u;  /* Stepm, step in month: minimum step interpolation*/
           if (fu <= fw || w == x) {  
             v=w;  int estepm;
             w=u;  /* Estepm, step in month to interpolate survival function in order to approximate Life Expectancy*/
             fv=fw;  
             fw=fu;  int m,nb;
           } else if (fu <= fv || v == x || v == w) {  long *num;
             v=u;  int firstpass=0, lastpass=4,*cod, *ncodemax, *Tage,*cens;
             fv=fu;  double **agev,*moisnais, *annais, *moisdc, *andc,**mint, **anint;
           }  double **pmmij, ***probs;
         }  double *ageexmed,*agecens;
   }  double dateintmean=0;
   nrerror("Too many iterations in brent");  
   *xmin=x;  double *weight;
   return fx;  int **s; /* Status */
 }  double *agedc, **covar, idx;
   int **nbcode, *Tcode, *Tvar, **codtab, **Tvard, *Tprod, cptcovprod, *Tvaraff;
 /****************** mnbrak ***********************/  double *lsurv, *lpop, *tpop;
   
 void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc,  double ftol=FTOL; /* Tolerance for computing Max Likelihood */
             double (*func)(double))  double ftolhess; /* Tolerance for computing hessian */
 {  
   double ulim,u,r,q, dum;  /**************** split *************************/
   double fu;  static  int split( char *path, char *dirc, char *name, char *ext, char *finame )
    {
   *fa=(*func)(*ax);    /* From a file name with (full) path (either Unix or Windows) we extract the directory (dirc)
   *fb=(*func)(*bx);       the name of the file (name), its extension only (ext) and its first part of the name (finame)
   if (*fb > *fa) {    */ 
     SHFT(dum,*ax,*bx,dum)    char  *ss;                            /* pointer */
       SHFT(dum,*fb,*fa,dum)    int   l1, l2;                         /* length counters */
       }  
   *cx=(*bx)+GOLD*(*bx-*ax);    l1 = strlen(path );                   /* length of path */
   *fc=(*func)(*cx);    if ( l1 == 0 ) return( GLOCK_ERROR_NOPATH );
   while (*fb > *fc) {    ss= strrchr( path, DIRSEPARATOR );            /* find last / */
     r=(*bx-*ax)*(*fb-*fc);    if ( ss == NULL ) {                   /* no directory, so determine current directory */
     q=(*bx-*cx)*(*fb-*fa);      strcpy( name, path );               /* we got the fullname name because no directory */
     u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/      /*if(strrchr(path, ODIRSEPARATOR )==NULL)
       (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r));        printf("Warning you should use %s as a separator\n",DIRSEPARATOR);*/
     ulim=(*bx)+GLIMIT*(*cx-*bx);      /* get current working directory */
     if ((*bx-u)*(u-*cx) > 0.0) {      /*    extern  char* getcwd ( char *buf , int len);*/
       fu=(*func)(u);      if ( getcwd( dirc, FILENAME_MAX ) == NULL ) {
     } else if ((*cx-u)*(u-ulim) > 0.0) {        return( GLOCK_ERROR_GETCWD );
       fu=(*func)(u);      }
       if (fu < *fc) {      /* got dirc from getcwd*/
         SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx))      printf(" DIRC = %s \n",dirc);
           SHFT(*fb,*fc,fu,(*func)(u))    } else {                              /* strip direcotry from path */
           }      ss++;                               /* after this, the filename */
     } else if ((u-ulim)*(ulim-*cx) >= 0.0) {      l2 = strlen( ss );                  /* length of filename */
       u=ulim;      if ( l2 == 0 ) return( GLOCK_ERROR_NOPATH );
       fu=(*func)(u);      strcpy( name, ss );         /* save file name */
     } else {      strncpy( dirc, path, l1 - l2 );     /* now the directory */
       u=(*cx)+GOLD*(*cx-*bx);      dirc[l1-l2] = 0;                    /* add zero */
       fu=(*func)(u);      printf(" DIRC2 = %s \n",dirc);
     }    }
     SHFT(*ax,*bx,*cx,u)    /* We add a separator at the end of dirc if not exists */
       SHFT(*fa,*fb,*fc,fu)    l1 = strlen( dirc );                  /* length of directory */
       }    if( dirc[l1-1] != DIRSEPARATOR ){
 }      dirc[l1] =  DIRSEPARATOR;
       dirc[l1+1] = 0; 
 /*************** linmin ************************/      printf(" DIRC3 = %s \n",dirc);
     }
 int ncom;    ss = strrchr( name, '.' );            /* find last / */
 double *pcom,*xicom;    if (ss >0){
 double (*nrfunc)(double []);      ss++;
        strcpy(ext,ss);                     /* save extension */
 void linmin(double p[], double xi[], int n, double *fret,double (*func)(double []))      l1= strlen( name);
 {      l2= strlen(ss)+1;
   double brent(double ax, double bx, double cx,      strncpy( finame, name, l1-l2);
                double (*f)(double), double tol, double *xmin);      finame[l1-l2]= 0;
   double f1dim(double x);    }
   void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb,  
               double *fc, double (*func)(double));    return( 0 );                          /* we're done */
   int j;  }
   double xx,xmin,bx,ax;  
   double fx,fb,fa;  
    /******************************************/
   ncom=n;  
   pcom=vector(1,n);  void replace_back_to_slash(char *s, char*t)
   xicom=vector(1,n);  {
   nrfunc=func;    int i;
   for (j=1;j<=n;j++) {    int lg=0;
     pcom[j]=p[j];    i=0;
     xicom[j]=xi[j];    lg=strlen(t);
   }    for(i=0; i<= lg; i++) {
   ax=0.0;      (s[i] = t[i]);
   xx=1.0;      if (t[i]== '\\') s[i]='/';
   mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim);    }
   *fret=brent(ax,xx,bx,f1dim,TOL,&xmin);  }
 #ifdef DEBUG  
   printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);  int nbocc(char *s, char occ)
 #endif  {
   for (j=1;j<=n;j++) {    int i,j=0;
     xi[j] *= xmin;    int lg=20;
     p[j] += xi[j];    i=0;
   }    lg=strlen(s);
   free_vector(xicom,1,n);    for(i=0; i<= lg; i++) {
   free_vector(pcom,1,n);    if  (s[i] == occ ) j++;
 }    }
     return j;
 /*************** powell ************************/  }
 void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret,  
             double (*func)(double []))  void cutv(char *u,char *v, char*t, char occ)
 {  {
   void linmin(double p[], double xi[], int n, double *fret,    /* cuts string t into u and v where u ends before first occurence of char 'occ' 
               double (*func)(double []));       and v starts after first occurence of char 'occ' : ex cutv(u,v,"abcdef2ghi2j",'2')
   int i,ibig,j;       gives u="abcedf" and v="ghi2j" */
   double del,t,*pt,*ptt,*xit;    int i,lg,j,p=0;
   double fp,fptt;    i=0;
   double *xits;    for(j=0; j<=strlen(t)-1; j++) {
   pt=vector(1,n);      if((t[j]!= occ) && (t[j+1]== occ)) p=j+1;
   ptt=vector(1,n);    }
   xit=vector(1,n);  
   xits=vector(1,n);    lg=strlen(t);
   *fret=(*func)(p);    for(j=0; j<p; j++) {
   for (j=1;j<=n;j++) pt[j]=p[j];      (u[j] = t[j]);
   for (*iter=1;;++(*iter)) {    }
     fp=(*fret);       u[p]='\0';
     ibig=0;  
     del=0.0;     for(j=0; j<= lg; j++) {
     printf("\nPowell iter=%d -2*LL=%.12f",*iter,*fret);      if (j>=(p+1))(v[j-p-1] = t[j]);
     for (i=1;i<=n;i++)    }
       printf(" %d %.12f",i, p[i]);  }
     printf("\n");  
     for (i=1;i<=n;i++) {  /********************** nrerror ********************/
       for (j=1;j<=n;j++) xit[j]=xi[j][i];  
       fptt=(*fret);  void nrerror(char error_text[])
 #ifdef DEBUG  {
       printf("fret=%lf \n",*fret);    fprintf(stderr,"ERREUR ...\n");
 #endif    fprintf(stderr,"%s\n",error_text);
       printf("%d",i);fflush(stdout);    exit(EXIT_FAILURE);
       linmin(p,xit,n,fret,func);  }
       if (fabs(fptt-(*fret)) > del) {  /*********************** vector *******************/
         del=fabs(fptt-(*fret));  double *vector(int nl, int nh)
         ibig=i;  {
       }    double *v;
 #ifdef DEBUG    v=(double *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(double)));
       printf("%d %.12e",i,(*fret));    if (!v) nrerror("allocation failure in vector");
       for (j=1;j<=n;j++) {    return v-nl+NR_END;
         xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);  }
         printf(" x(%d)=%.12e",j,xit[j]);  
       }  /************************ free vector ******************/
       for(j=1;j<=n;j++)  void free_vector(double*v, int nl, int nh)
         printf(" p=%.12e",p[j]);  {
       printf("\n");    free((FREE_ARG)(v+nl-NR_END));
 #endif  }
     }  
     if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {  /************************ivector *******************************/
 #ifdef DEBUG  int *ivector(long nl,long nh)
       int k[2],l;  {
       k[0]=1;    int *v;
       k[1]=-1;    v=(int *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(int)));
       printf("Max: %.12e",(*func)(p));    if (!v) nrerror("allocation failure in ivector");
       for (j=1;j<=n;j++)    return v-nl+NR_END;
         printf(" %.12e",p[j]);  }
       printf("\n");  
       for(l=0;l<=1;l++) {  /******************free ivector **************************/
         for (j=1;j<=n;j++) {  void free_ivector(int *v, long nl, long nh)
           ptt[j]=p[j]+(p[j]-pt[j])*k[l];  {
           printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);    free((FREE_ARG)(v+nl-NR_END));
         }  }
         printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));  
       }  /************************lvector *******************************/
 #endif  long *lvector(long nl,long nh)
   {
     long *v;
       free_vector(xit,1,n);    v=(long *) malloc((size_t)((nh-nl+1+NR_END)*sizeof(long)));
       free_vector(xits,1,n);    if (!v) nrerror("allocation failure in ivector");
       free_vector(ptt,1,n);    return v-nl+NR_END;
       free_vector(pt,1,n);  }
       return;  
     }  /******************free lvector **************************/
     if (*iter == ITMAX) nrerror("powell exceeding maximum iterations.");  void free_lvector(long *v, long nl, long nh)
     for (j=1;j<=n;j++) {  {
       ptt[j]=2.0*p[j]-pt[j];    free((FREE_ARG)(v+nl-NR_END));
       xit[j]=p[j]-pt[j];  }
       pt[j]=p[j];  
     }  /******************* imatrix *******************************/
     fptt=(*func)(ptt);  int **imatrix(long nrl, long nrh, long ncl, long nch) 
     if (fptt < fp) {       /* allocate a int matrix with subscript range m[nrl..nrh][ncl..nch] */ 
       t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt);  { 
       if (t < 0.0) {    long i, nrow=nrh-nrl+1,ncol=nch-ncl+1; 
         linmin(p,xit,n,fret,func);    int **m; 
         for (j=1;j<=n;j++) {    
           xi[j][ibig]=xi[j][n];    /* allocate pointers to rows */ 
           xi[j][n]=xit[j];    m=(int **) malloc((size_t)((nrow+NR_END)*sizeof(int*))); 
         }    if (!m) nrerror("allocation failure 1 in matrix()"); 
 #ifdef DEBUG    m += NR_END; 
         printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);    m -= nrl; 
         for(j=1;j<=n;j++)    
           printf(" %.12e",xit[j]);    
         printf("\n");    /* allocate rows and set pointers to them */ 
 #endif    m[nrl]=(int *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(int))); 
       }    if (!m[nrl]) nrerror("allocation failure 2 in matrix()"); 
     }    m[nrl] += NR_END; 
   }    m[nrl] -= ncl; 
 }    
     for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol; 
 /**** Prevalence limit ****************/    
     /* return pointer to array of pointers to rows */ 
 double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)    return m; 
 {  } 
   /* Computes the prevalence limit in each live state at age x by left multiplying the unit  
      matrix by transitions matrix until convergence is reached */  /****************** free_imatrix *************************/
   void free_imatrix(m,nrl,nrh,ncl,nch)
   int i, ii,j,k;        int **m;
   double min, max, maxmin, maxmax,sumnew=0.;        long nch,ncl,nrh,nrl; 
   double **matprod2();       /* free an int matrix allocated by imatrix() */ 
   double **out, cov[NCOVMAX], **pmij();  { 
   double **newm;    free((FREE_ARG) (m[nrl]+ncl-NR_END)); 
   double agefin, delaymax=50 ; /* Max number of years to converge */    free((FREE_ARG) (m+nrl-NR_END)); 
   } 
   for (ii=1;ii<=nlstate+ndeath;ii++)  
     for (j=1;j<=nlstate+ndeath;j++){  /******************* matrix *******************************/
       oldm[ii][j]=(ii==j ? 1.0 : 0.0);  double **matrix(long nrl, long nrh, long ncl, long nch)
     }  {
     long i, nrow=nrh-nrl+1, ncol=nch-ncl+1;
    cov[1]=1.;    double **m;
    
  /* Even if hstepm = 1, at least one multiplication by the unit matrix */    m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
   for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){    if (!m) nrerror("allocation failure 1 in matrix()");
     newm=savm;    m += NR_END;
     /* Covariates have to be included here again */    m -= nrl;
      cov[2]=agefin;  
      m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
       for (k=1; k<=cptcovn;k++) {    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
         cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];    m[nrl] += NR_END;
         /*printf("ij=%d Tvar[k]=%d nbcode=%d cov=%lf\n",ij, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k]);*/    m[nrl] -= ncl;
       }  
       for (k=1; k<=cptcovage;k++)    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];    return m;
       for (k=1; k<=cptcovprod;k++)    /* print *(*(m+1)+70) or print m[1][70]; print m+1 or print &(m[1]) 
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];     */
   }
       /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/  
   /*************************free matrix ************************/
       /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/  void free_matrix(double **m, long nrl, long nrh, long ncl, long nch)
   {
     out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);    free((FREE_ARG)(m[nrl]+ncl-NR_END));
     free((FREE_ARG)(m+nrl-NR_END));
     savm=oldm;  }
     oldm=newm;  
     maxmax=0.;  /******************* ma3x *******************************/
     for(j=1;j<=nlstate;j++){  double ***ma3x(long nrl, long nrh, long ncl, long nch, long nll, long nlh)
       min=1.;  {
       max=0.;    long i, j, nrow=nrh-nrl+1, ncol=nch-ncl+1, nlay=nlh-nll+1;
       for(i=1; i<=nlstate; i++) {    double ***m;
         sumnew=0;  
         for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];    m=(double ***) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
         prlim[i][j]= newm[i][j]/(1-sumnew);    if (!m) nrerror("allocation failure 1 in matrix()");
         max=FMAX(max,prlim[i][j]);    m += NR_END;
         min=FMIN(min,prlim[i][j]);    m -= nrl;
       }  
       maxmin=max-min;    m[nrl]=(double **) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
       maxmax=FMAX(maxmax,maxmin);    if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
     }    m[nrl] += NR_END;
     if(maxmax < ftolpl){    m[nrl] -= ncl;
       return prlim;  
     }    for (i=nrl+1; i<=nrh; i++) m[i]=m[i-1]+ncol;
   }  
 }    m[nrl][ncl]=(double *) malloc((size_t)((nrow*ncol*nlay+NR_END)*sizeof(double)));
     if (!m[nrl][ncl]) nrerror("allocation failure 3 in matrix()");
 /*************** transition probabilities **********/    m[nrl][ncl] += NR_END;
     m[nrl][ncl] -= nll;
 double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )    for (j=ncl+1; j<=nch; j++) 
 {      m[nrl][j]=m[nrl][j-1]+nlay;
   double s1, s2;    
   /*double t34;*/    for (i=nrl+1; i<=nrh; i++) {
   int i,j,j1, nc, ii, jj;      m[i][ncl]=m[i-1l][ncl]+ncol*nlay;
       for (j=ncl+1; j<=nch; j++) 
     for(i=1; i<= nlstate; i++){        m[i][j]=m[i][j-1]+nlay;
     for(j=1; j<i;j++){    }
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){    return m; 
         /*s2 += param[i][j][nc]*cov[nc];*/    /*  gdb: p *(m+1) <=> p m[1] and p (m+1) <=> p (m+1) <=> p &(m[1])
         s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];             &(m[i][j][k]) <=> *((*(m+i) + j)+k)
         /*printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2);*/    */
       }  }
       ps[i][j]=s2;  
       /*printf("s1=%.17e, s2=%.17e\n",s1,s2);*/  /*************************free ma3x ************************/
     }  void free_ma3x(double ***m, long nrl, long nrh, long ncl, long nch,long nll, long nlh)
     for(j=i+1; j<=nlstate+ndeath;j++){  {
       for (nc=1, s2=0.;nc <=ncovmodel; nc++){    free((FREE_ARG)(m[nrl][ncl]+ nll-NR_END));
         s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];    free((FREE_ARG)(m[nrl]+ncl-NR_END));
         /*printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2);*/    free((FREE_ARG)(m+nrl-NR_END));
       }  }
       ps[i][j]=s2;  
     }  /*************** function subdirf ***********/
   }  char *subdirf(char fileres[])
   for(i=1; i<= nlstate; i++){  {
      s1=0;    /* Caution optionfilefiname is hidden */
     for(j=1; j<i; j++)    strcpy(tmpout,optionfilefiname);
       s1+=exp(ps[i][j]);    strcat(tmpout,"/"); /* Add to the right */
     for(j=i+1; j<=nlstate+ndeath; j++)    strcat(tmpout,fileres);
       s1+=exp(ps[i][j]);    return tmpout;
     ps[i][i]=1./(s1+1.);  }
     for(j=1; j<i; j++)  
       ps[i][j]= exp(ps[i][j])*ps[i][i];  /*************** function subdirf2 ***********/
     for(j=i+1; j<=nlstate+ndeath; j++)  char *subdirf2(char fileres[], char *preop)
       ps[i][j]= exp(ps[i][j])*ps[i][i];  {
     /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */    
   } /* end i */    /* Caution optionfilefiname is hidden */
     strcpy(tmpout,optionfilefiname);
   for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){    strcat(tmpout,"/");
     for(jj=1; jj<= nlstate+ndeath; jj++){    strcat(tmpout,preop);
       ps[ii][jj]=0;    strcat(tmpout,fileres);
       ps[ii][ii]=1;    return tmpout;
     }  }
   }  
   /*************** function subdirf3 ***********/
   /*   for(ii=1; ii<= nlstate+ndeath; ii++){  char *subdirf3(char fileres[], char *preop, char *preop2)
     for(jj=1; jj<= nlstate+ndeath; jj++){  {
      printf("%lf ",ps[ii][jj]);    
    }    /* Caution optionfilefiname is hidden */
     printf("\n ");    strcpy(tmpout,optionfilefiname);
     }    strcat(tmpout,"/");
     printf("\n ");printf("%lf ",cov[2]);*/    strcat(tmpout,preop);
 /*    strcat(tmpout,preop2);
   for(i=1; i<= npar; i++) printf("%f ",x[i]);    strcat(tmpout,fileres);
   goto end;*/    return tmpout;
     return ps;  }
 }  
   /***************** f1dim *************************/
 /**************** Product of 2 matrices ******************/  extern int ncom; 
   extern double *pcom,*xicom;
 double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)  extern double (*nrfunc)(double []); 
 {   
   /* Computes the matric product of in(1,nrh-nrl+1)(1,nch-ncl+1) times  double f1dim(double x) 
      b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */  { 
   /* in, b, out are matrice of pointers which should have been initialized    int j; 
      before: only the contents of out is modified. The function returns    double f;
      a pointer to pointers identical to out */    double *xt; 
   long i, j, k;   
   for(i=nrl; i<= nrh; i++)    xt=vector(1,ncom); 
     for(k=ncolol; k<=ncoloh; k++)    for (j=1;j<=ncom;j++) xt[j]=pcom[j]+x*xicom[j]; 
       for(j=ncl,out[i][k]=0.; j<=nch; j++)    f=(*nrfunc)(xt); 
         out[i][k] +=in[i][j]*b[j][k];    free_vector(xt,1,ncom); 
     return f; 
   return out;  } 
 }  
   /*****************brent *************************/
   double brent(double ax, double bx, double cx, double (*f)(double), double tol,  double *xmin) 
 /************* Higher Matrix Product ***************/  { 
     int iter; 
 double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )    double a,b,d,etemp;
 {    double fu,fv,fw,fx;
   /* Computes the transition matrix starting at age 'age' over 'nhstepm*hstepm*stepm' month    double ftemp;
      duration (i.e. until    double p,q,r,tol1,tol2,u,v,w,x,xm; 
      age (in years)  age+nhstepm*stepm/12) by multiplying nhstepm*hstepm matrices.    double e=0.0; 
      Output is stored in matrix po[i][j][h] for h every 'hstepm' step   
      (typically every 2 years instead of every month which is too big).    a=(ax < cx ? ax : cx); 
      Model is determined by parameters x and covariates have to be    b=(ax > cx ? ax : cx); 
      included manually here.    x=w=v=bx; 
     fw=fv=fx=(*f)(x); 
      */    for (iter=1;iter<=ITMAX;iter++) { 
       xm=0.5*(a+b); 
   int i, j, d, h, k;      tol2=2.0*(tol1=tol*fabs(x)+ZEPS); 
   double **out, cov[NCOVMAX];      /*          if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret)))*/
   double **newm;      printf(".");fflush(stdout);
       fprintf(ficlog,".");fflush(ficlog);
   /* Hstepm could be zero and should return the unit matrix */  #ifdef DEBUG
   for (i=1;i<=nlstate+ndeath;i++)      printf("br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
     for (j=1;j<=nlstate+ndeath;j++){      fprintf(ficlog,"br %d,x=%.10e xm=%.10e b=%.10e a=%.10e tol=%.10e tol1=%.10e tol2=%.10e x-xm=%.10e fx=%.12e fu=%.12e,fw=%.12e,ftemp=%.12e,ftol=%.12e\n",iter,x,xm,b,a,tol,tol1,tol2,(x-xm),fx,fu,fw,ftemp,ftol);
       oldm[i][j]=(i==j ? 1.0 : 0.0);      /*          if ((fabs(x-xm) <= (tol2-0.5*(b-a)))||(2.0*fabs(fu-ftemp) <= ftol*1.e-2*(fabs(fu)+fabs(ftemp)))) { */
       po[i][j][0]=(i==j ? 1.0 : 0.0);  #endif
     }      if (fabs(x-xm) <= (tol2-0.5*(b-a))){ 
   /* Even if hstepm = 1, at least one multiplication by the unit matrix */        *xmin=x; 
   for(h=1; h <=nhstepm; h++){        return fx; 
     for(d=1; d <=hstepm; d++){      } 
       newm=savm;      ftemp=fu;
       /* Covariates have to be included here again */      if (fabs(e) > tol1) { 
       cov[1]=1.;        r=(x-w)*(fx-fv); 
       cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;        q=(x-v)*(fx-fw); 
       for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];        p=(x-v)*q-(x-w)*r; 
 for (k=1; k<=cptcovage;k++)        q=2.0*(q-r); 
         cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];        if (q > 0.0) p = -p; 
    for (k=1; k<=cptcovprod;k++)        q=fabs(q); 
         cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];        etemp=e; 
         e=d; 
         if (fabs(p) >= fabs(0.5*q*etemp) || p <= q*(a-x) || p >= q*(b-x)) 
       /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/          d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
       /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/        else { 
       out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath,          d=p/q; 
                    pmij(pmmij,cov,ncovmodel,x,nlstate));          u=x+d; 
       savm=oldm;          if (u-a < tol2 || b-u < tol2) 
       oldm=newm;            d=SIGN(tol1,xm-x); 
     }        } 
     for(i=1; i<=nlstate+ndeath; i++)      } else { 
       for(j=1;j<=nlstate+ndeath;j++) {        d=CGOLD*(e=(x >= xm ? a-x : b-x)); 
         po[i][j][h]=newm[i][j];      } 
         /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);      u=(fabs(d) >= tol1 ? x+d : x+SIGN(tol1,d)); 
          */      fu=(*f)(u); 
       }      if (fu <= fx) { 
   } /* end h */        if (u >= x) a=x; else b=x; 
   return po;        SHFT(v,w,x,u) 
 }          SHFT(fv,fw,fx,fu) 
           } else { 
             if (u < x) a=u; else b=u; 
 /*************** log-likelihood *************/            if (fu <= fw || w == x) { 
 double func( double *x)              v=w; 
 {              w=u; 
   int i, ii, j, k, mi, d, kk;              fv=fw; 
   double l, ll[NLSTATEMAX], cov[NCOVMAX];              fw=fu; 
   double **out;            } else if (fu <= fv || v == x || v == w) { 
   double sw; /* Sum of weights */              v=u; 
   double lli; /* Individual log likelihood */              fv=fu; 
   long ipmx;            } 
   /*extern weight */          } 
   /* We are differentiating ll according to initial status */    } 
   /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/    nrerror("Too many iterations in brent"); 
   /*for(i=1;i<imx;i++)    *xmin=x; 
 printf(" %d\n",s[4][i]);    return fx; 
   */  } 
   cov[1]=1.;  
   /****************** mnbrak ***********************/
   for(k=1; k<=nlstate; k++) ll[k]=0.;  
   for (i=1,ipmx=0, sw=0.; i<=imx; i++){  void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, double *fc, 
     for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];              double (*func)(double)) 
        for(mi=1; mi<= wav[i]-1; mi++){  { 
       for (ii=1;ii<=nlstate+ndeath;ii++)    double ulim,u,r,q, dum;
         for (j=1;j<=nlstate+ndeath;j++) oldm[ii][j]=(ii==j ? 1.0 : 0.0);    double fu; 
             for(d=0; d<dh[mi][i]; d++){   
               newm=savm;    *fa=(*func)(*ax); 
               cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;    *fb=(*func)(*bx); 
               for (kk=1; kk<=cptcovage;kk++) {    if (*fb > *fa) { 
                  cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];      SHFT(dum,*ax,*bx,dum) 
                  /*printf("%d %d",kk,Tage[kk]);*/        SHFT(dum,*fb,*fa,dum) 
               }        } 
               /*cov[4]=covar[1][i]*cov[2];scanf("%d", i);*/    *cx=(*bx)+GOLD*(*bx-*ax); 
               /*cov[3]=pow(cov[2],2)/1000.;*/    *fc=(*func)(*cx); 
     while (*fb > *fc) { 
           out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,      r=(*bx-*ax)*(*fb-*fc); 
                        1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));      q=(*bx-*cx)*(*fb-*fa); 
           savm=oldm;      u=(*bx)-((*bx-*cx)*q-(*bx-*ax)*r)/ 
           oldm=newm;        (2.0*SIGN(FMAX(fabs(q-r),TINY),q-r)); 
       ulim=(*bx)+GLIMIT*(*cx-*bx); 
       if ((*bx-u)*(u-*cx) > 0.0) { 
       } /* end mult */        fu=(*func)(u); 
          } else if ((*cx-u)*(u-ulim) > 0.0) { 
       lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);        fu=(*func)(u); 
       /* printf(" %f ",out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/        if (fu < *fc) { 
       ipmx +=1;          SHFT(*bx,*cx,u,*cx+GOLD*(*cx-*bx)) 
       sw += weight[i];            SHFT(*fb,*fc,fu,(*func)(u)) 
       ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;            } 
     } /* end of wave */      } else if ((u-ulim)*(ulim-*cx) >= 0.0) { 
   } /* end of individual */        u=ulim; 
         fu=(*func)(u); 
   for(k=1,l=0.; k<=nlstate; k++) l += ll[k];      } else { 
   /* printf("l1=%f l2=%f ",ll[1],ll[2]); */        u=(*cx)+GOLD*(*cx-*bx); 
   l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */        fu=(*func)(u); 
   return -l;      } 
 }      SHFT(*ax,*bx,*cx,u) 
         SHFT(*fa,*fb,*fc,fu) 
         } 
 /*********** Maximum Likelihood Estimation ***************/  } 
   
 void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))  /*************** linmin ************************/
 {  
   int i,j, iter;  int ncom; 
   double **xi,*delti;  double *pcom,*xicom;
   double fret;  double (*nrfunc)(double []); 
   xi=matrix(1,npar,1,npar);   
   for (i=1;i<=npar;i++)  void linmin(double p[], double xi[], int n, double *fret,double (*func)(double [])) 
     for (j=1;j<=npar;j++)  { 
       xi[i][j]=(i==j ? 1.0 : 0.0);    double brent(double ax, double bx, double cx, 
   printf("Powell\n");                 double (*f)(double), double tol, double *xmin); 
   powell(p,xi,npar,ftol,&iter,&fret,func);    double f1dim(double x); 
     void mnbrak(double *ax, double *bx, double *cx, double *fa, double *fb, 
    printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));                double *fc, double (*func)(double)); 
   fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f ",iter,func(p));    int j; 
     double xx,xmin,bx,ax; 
 }    double fx,fb,fa;
    
 /**** Computes Hessian and covariance matrix ***/    ncom=n; 
 void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))    pcom=vector(1,n); 
 {    xicom=vector(1,n); 
   double  **a,**y,*x,pd;    nrfunc=func; 
   double **hess;    for (j=1;j<=n;j++) { 
   int i, j,jk;      pcom[j]=p[j]; 
   int *indx;      xicom[j]=xi[j]; 
     } 
   double hessii(double p[], double delta, int theta, double delti[]);    ax=0.0; 
   double hessij(double p[], double delti[], int i, int j);    xx=1.0; 
   void lubksb(double **a, int npar, int *indx, double b[]) ;    mnbrak(&ax,&xx,&bx,&fa,&fx,&fb,f1dim); 
   void ludcmp(double **a, int npar, int *indx, double *d) ;    *fret=brent(ax,xx,bx,f1dim,TOL,&xmin); 
   #ifdef DEBUG
     printf("retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
   hess=matrix(1,npar,1,npar);    fprintf(ficlog,"retour brent fret=%.12e xmin=%.12e\n",*fret,xmin);
   #endif
   printf("\nCalculation of the hessian matrix. Wait...\n");    for (j=1;j<=n;j++) { 
   for (i=1;i<=npar;i++){      xi[j] *= xmin; 
     printf("%d",i);fflush(stdout);      p[j] += xi[j]; 
     hess[i][i]=hessii(p,ftolhess,i,delti);    } 
     /*printf(" %f ",p[i]);*/    free_vector(xicom,1,n); 
   }    free_vector(pcom,1,n); 
   } 
   for (i=1;i<=npar;i++) {  
     for (j=1;j<=npar;j++)  {  char *asc_diff_time(long time_sec, char ascdiff[])
       if (j>i) {  {
         printf(".%d%d",i,j);fflush(stdout);    long sec_left, days, hours, minutes;
         hess[i][j]=hessij(p,delti,i,j);    days = (time_sec) / (60*60*24);
         hess[j][i]=hess[i][j];    sec_left = (time_sec) % (60*60*24);
       }    hours = (sec_left) / (60*60) ;
     }    sec_left = (sec_left) %(60*60);
   }    minutes = (sec_left) /60;
   printf("\n");    sec_left = (sec_left) % (60);
     sprintf(ascdiff,"%d day(s) %d hour(s) %d minute(s) %d second(s)",days, hours, minutes, sec_left);  
   printf("\nInverting the hessian to get the covariance matrix. Wait...\n");    return ascdiff;
    }
   a=matrix(1,npar,1,npar);  
   y=matrix(1,npar,1,npar);  /*************** powell ************************/
   x=vector(1,npar);  void powell(double p[], double **xi, int n, double ftol, int *iter, double *fret, 
   indx=ivector(1,npar);              double (*func)(double [])) 
   for (i=1;i<=npar;i++)  { 
     for (j=1;j<=npar;j++) a[i][j]=hess[i][j];    void linmin(double p[], double xi[], int n, double *fret, 
   ludcmp(a,npar,indx,&pd);                double (*func)(double [])); 
     int i,ibig,j; 
   for (j=1;j<=npar;j++) {    double del,t,*pt,*ptt,*xit;
     for (i=1;i<=npar;i++) x[i]=0;    double fp,fptt;
     x[j]=1;    double *xits;
     lubksb(a,npar,indx,x);    int niterf, itmp;
     for (i=1;i<=npar;i++){  
       matcov[i][j]=x[i];    pt=vector(1,n); 
     }    ptt=vector(1,n); 
   }    xit=vector(1,n); 
     xits=vector(1,n); 
   printf("\n#Hessian matrix#\n");    *fret=(*func)(p); 
   for (i=1;i<=npar;i++) {    for (j=1;j<=n;j++) pt[j]=p[j]; 
     for (j=1;j<=npar;j++) {    for (*iter=1;;++(*iter)) { 
       printf("%.3e ",hess[i][j]);      fp=(*fret); 
     }      ibig=0; 
     printf("\n");      del=0.0; 
   }      last_time=curr_time;
       (void) gettimeofday(&curr_time,&tzp);
   /* Recompute Inverse */      printf("\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);fflush(stdout);
   for (i=1;i<=npar;i++)      /*    fprintf(ficlog,"\nPowell iter=%d -2*LL=%.12f %ld sec. %ld sec.",*iter,*fret, curr_time.tv_sec-last_time.tv_sec, curr_time.tv_sec-start_time.tv_sec);
     for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];      fprintf(ficrespow,"%d %.12f %ld",*iter,*fret,curr_time.tv_sec-start_time.tv_sec);
   ludcmp(a,npar,indx,&pd);      */
      for (i=1;i<=n;i++) {
   /*  printf("\n#Hessian matrix recomputed#\n");        printf(" %d %.12f",i, p[i]);
         fprintf(ficlog," %d %.12lf",i, p[i]);
   for (j=1;j<=npar;j++) {        fprintf(ficrespow," %.12lf", p[i]);
     for (i=1;i<=npar;i++) x[i]=0;      }
     x[j]=1;      printf("\n");
     lubksb(a,npar,indx,x);      fprintf(ficlog,"\n");
     for (i=1;i<=npar;i++){      fprintf(ficrespow,"\n");fflush(ficrespow);
       y[i][j]=x[i];      if(*iter <=3){
       printf("%.3e ",y[i][j]);        tm = *localtime(&curr_time.tv_sec);
     }        strcpy(strcurr,asctime(&tm));
     printf("\n");  /*       asctime_r(&tm,strcurr); */
   }        forecast_time=curr_time; 
   */        itmp = strlen(strcurr);
         if(strcurr[itmp-1]=='\n')  /* Windows outputs with a new line */
   free_matrix(a,1,npar,1,npar);          strcurr[itmp-1]='\0';
   free_matrix(y,1,npar,1,npar);        printf("\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
   free_vector(x,1,npar);        fprintf(ficlog,"\nConsidering the time needed for this last iteration #%d: %ld seconds,\n",*iter,curr_time.tv_sec-last_time.tv_sec);
   free_ivector(indx,1,npar);        for(niterf=10;niterf<=30;niterf+=10){
   free_matrix(hess,1,npar,1,npar);          forecast_time.tv_sec=curr_time.tv_sec+(niterf-*iter)*(curr_time.tv_sec-last_time.tv_sec);
           tmf = *localtime(&forecast_time.tv_sec);
   /*      asctime_r(&tmf,strfor); */
 }          strcpy(strfor,asctime(&tmf));
           itmp = strlen(strfor);
 /*************** hessian matrix ****************/          if(strfor[itmp-1]=='\n')
 double hessii( double x[], double delta, int theta, double delti[])          strfor[itmp-1]='\0';
 {          printf("   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   int i;          fprintf(ficlog,"   - if your program needs %d iterations to converge, convergence will be \n   reached in %s i.e.\n   on %s (current time is %s);\n",niterf, asc_diff_time(forecast_time.tv_sec-curr_time.tv_sec,tmpout),strfor,strcurr);
   int l=1, lmax=20;        }
   double k1,k2;      }
   double p2[NPARMAX+1];      for (i=1;i<=n;i++) { 
   double res;        for (j=1;j<=n;j++) xit[j]=xi[j][i]; 
   double delt, delts, nkhi=10.,nkhif=1., khi=1.e-4;        fptt=(*fret); 
   double fx;  #ifdef DEBUG
   int k=0,kmax=10;        printf("fret=%lf \n",*fret);
   double l1;        fprintf(ficlog,"fret=%lf \n",*fret);
   #endif
   fx=func(x);        printf("%d",i);fflush(stdout);
   for (i=1;i<=npar;i++) p2[i]=x[i];        fprintf(ficlog,"%d",i);fflush(ficlog);
   for(l=0 ; l <=lmax; l++){        linmin(p,xit,n,fret,func); 
     l1=pow(10,l);        if (fabs(fptt-(*fret)) > del) { 
     delts=delt;          del=fabs(fptt-(*fret)); 
     for(k=1 ; k <kmax; k=k+1){          ibig=i; 
       delt = delta*(l1*k);        } 
       p2[theta]=x[theta] +delt;  #ifdef DEBUG
       k1=func(p2)-fx;        printf("%d %.12e",i,(*fret));
       p2[theta]=x[theta]-delt;        fprintf(ficlog,"%d %.12e",i,(*fret));
       k2=func(p2)-fx;        for (j=1;j<=n;j++) {
       /*res= (k1-2.0*fx+k2)/delt/delt; */          xits[j]=FMAX(fabs(p[j]-pt[j]),1.e-5);
       res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */          printf(" x(%d)=%.12e",j,xit[j]);
                fprintf(ficlog," x(%d)=%.12e",j,xit[j]);
 #ifdef DEBUG        }
       printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);        for(j=1;j<=n;j++) {
 #endif          printf(" p=%.12e",p[j]);
       /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */          fprintf(ficlog," p=%.12e",p[j]);
       if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){        }
         k=kmax;        printf("\n");
       }        fprintf(ficlog,"\n");
       else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */  #endif
         k=kmax; l=lmax*10.;      } 
       }      if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) {
       else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){  #ifdef DEBUG
         delts=delt;        int k[2],l;
       }        k[0]=1;
     }        k[1]=-1;
   }        printf("Max: %.12e",(*func)(p));
   delti[theta]=delts;        fprintf(ficlog,"Max: %.12e",(*func)(p));
   return res;        for (j=1;j<=n;j++) {
            printf(" %.12e",p[j]);
 }          fprintf(ficlog," %.12e",p[j]);
         }
 double hessij( double x[], double delti[], int thetai,int thetaj)        printf("\n");
 {        fprintf(ficlog,"\n");
   int i;        for(l=0;l<=1;l++) {
   int l=1, l1, lmax=20;          for (j=1;j<=n;j++) {
   double k1,k2,k3,k4,res,fx;            ptt[j]=p[j]+(p[j]-pt[j])*k[l];
   double p2[NPARMAX+1];            printf("l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
   int k;            fprintf(ficlog,"l=%d j=%d ptt=%.12e, xits=%.12e, p=%.12e, xit=%.12e", l,j,ptt[j],xits[j],p[j],xit[j]);
           }
   fx=func(x);          printf("func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
   for (k=1; k<=2; k++) {          fprintf(ficlog,"func(ptt)=%.12e, deriv=%.12e\n",(*func)(ptt),(ptt[j]-p[j])/((*func)(ptt)-(*func)(p)));
     for (i=1;i<=npar;i++) p2[i]=x[i];        }
     p2[thetai]=x[thetai]+delti[thetai]/k;  #endif
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;  
     k1=func(p2)-fx;  
          free_vector(xit,1,n); 
     p2[thetai]=x[thetai]+delti[thetai]/k;        free_vector(xits,1,n); 
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;        free_vector(ptt,1,n); 
     k2=func(p2)-fx;        free_vector(pt,1,n); 
          return; 
     p2[thetai]=x[thetai]-delti[thetai]/k;      } 
     p2[thetaj]=x[thetaj]+delti[thetaj]/k;      if (*iter == ITMAX) nrerror("powell exceeding maximum iterations."); 
     k3=func(p2)-fx;      for (j=1;j<=n;j++) { 
          ptt[j]=2.0*p[j]-pt[j]; 
     p2[thetai]=x[thetai]-delti[thetai]/k;        xit[j]=p[j]-pt[j]; 
     p2[thetaj]=x[thetaj]-delti[thetaj]/k;        pt[j]=p[j]; 
     k4=func(p2)-fx;      } 
     res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */      fptt=(*func)(ptt); 
 #ifdef DEBUG      if (fptt < fp) { 
     printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);        t=2.0*(fp-2.0*(*fret)+fptt)*SQR(fp-(*fret)-del)-del*SQR(fp-fptt); 
 #endif        if (t < 0.0) { 
   }          linmin(p,xit,n,fret,func); 
   return res;          for (j=1;j<=n;j++) { 
 }            xi[j][ibig]=xi[j][n]; 
             xi[j][n]=xit[j]; 
 /************** Inverse of matrix **************/          }
 void ludcmp(double **a, int n, int *indx, double *d)  #ifdef DEBUG
 {          printf("Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
   int i,imax,j,k;          fprintf(ficlog,"Direction changed  last moved %d in place of ibig=%d, new last is the average:\n",n,ibig);
   double big,dum,sum,temp;          for(j=1;j<=n;j++){
   double *vv;            printf(" %.12e",xit[j]);
              fprintf(ficlog," %.12e",xit[j]);
   vv=vector(1,n);          }
   *d=1.0;          printf("\n");
   for (i=1;i<=n;i++) {          fprintf(ficlog,"\n");
     big=0.0;  #endif
     for (j=1;j<=n;j++)        }
       if ((temp=fabs(a[i][j])) > big) big=temp;      } 
     if (big == 0.0) nrerror("Singular matrix in routine ludcmp");    } 
     vv[i]=1.0/big;  } 
   }  
   for (j=1;j<=n;j++) {  /**** Prevalence limit (stable or period prevalence)  ****************/
     for (i=1;i<j;i++) {  
       sum=a[i][j];  double **prevalim(double **prlim, int nlstate, double x[], double age, double **oldm, double **savm, double ftolpl, int ij)
       for (k=1;k<i;k++) sum -= a[i][k]*a[k][j];  {
       a[i][j]=sum;    /* Computes the prevalence limit in each live state at age x by left multiplying the unit
     }       matrix by transitions matrix until convergence is reached */
     big=0.0;  
     for (i=j;i<=n;i++) {    int i, ii,j,k;
       sum=a[i][j];    double min, max, maxmin, maxmax,sumnew=0.;
       for (k=1;k<j;k++)    double **matprod2();
         sum -= a[i][k]*a[k][j];    double **out, cov[NCOVMAX], **pmij();
       a[i][j]=sum;    double **newm;
       if ( (dum=vv[i]*fabs(sum)) >= big) {    double agefin, delaymax=50 ; /* Max number of years to converge */
         big=dum;  
         imax=i;    for (ii=1;ii<=nlstate+ndeath;ii++)
       }      for (j=1;j<=nlstate+ndeath;j++){
     }        oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     if (j != imax) {      }
       for (k=1;k<=n;k++) {  
         dum=a[imax][k];     cov[1]=1.;
         a[imax][k]=a[j][k];   
         a[j][k]=dum;   /* Even if hstepm = 1, at least one multiplication by the unit matrix */
       }    for(agefin=age-stepm/YEARM; agefin>=age-delaymax; agefin=agefin-stepm/YEARM){
       *d = -(*d);      newm=savm;
       vv[imax]=vv[j];      /* Covariates have to be included here again */
     }       cov[2]=agefin;
     indx[j]=imax;    
     if (a[j][j] == 0.0) a[j][j]=TINY;        for (k=1; k<=cptcovn;k++) {
     if (j != n) {          cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
       dum=1.0/(a[j][j]);          /*      printf("ij=%d k=%d Tvar[k]=%d nbcode=%d cov=%lf codtab[ij][Tvar[k]]=%d \n",ij,k, Tvar[k],nbcode[Tvar[k]][codtab[ij][Tvar[k]]],cov[2+k], codtab[ij][Tvar[k]]);*/
       for (i=j+1;i<=n;i++) a[i][j] *= dum;        }
     }        for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
   }        for (k=1; k<=cptcovprod;k++)
   free_vector(vv,1,n);  /* Doesn't work */          cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
 ;  
 }        /*printf("ij=%d cptcovprod=%d tvar=%d ", ij, cptcovprod, Tvar[1]);*/
         /*printf("ij=%d cov[3]=%lf cov[4]=%lf \n",ij, cov[3],cov[4]);*/
 void lubksb(double **a, int n, int *indx, double b[])        /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/
 {      out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm);
   int i,ii=0,ip,j;  
   double sum;      savm=oldm;
        oldm=newm;
   for (i=1;i<=n;i++) {      maxmax=0.;
     ip=indx[i];      for(j=1;j<=nlstate;j++){
     sum=b[ip];        min=1.;
     b[ip]=b[i];        max=0.;
     if (ii)        for(i=1; i<=nlstate; i++) {
       for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j];          sumnew=0;
     else if (sum) ii=i;          for(k=1; k<=ndeath; k++) sumnew+=newm[i][nlstate+k];
     b[i]=sum;          prlim[i][j]= newm[i][j]/(1-sumnew);
   }          max=FMAX(max,prlim[i][j]);
   for (i=n;i>=1;i--) {          min=FMIN(min,prlim[i][j]);
     sum=b[i];        }
     for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j];        maxmin=max-min;
     b[i]=sum/a[i][i];        maxmax=FMAX(maxmax,maxmin);
   }      }
 }      if(maxmax < ftolpl){
         return prlim;
 /************ Frequencies ********************/      }
 void  freqsummary(char fileres[], int agemin, int agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax)    }
 {  /* Some frequencies */  }
    
   int i, m, jk, k1, i1, j1, bool, z1,z2,j;  /*************** transition probabilities ***************/ 
   double ***freq; /* Frequencies */  
   double *pp;  double **pmij(double **ps, double *cov, int ncovmodel, double *x, int nlstate )
   double pos;  {
   FILE *ficresp;    double s1, s2;
   char fileresp[FILENAMELENGTH];    /*double t34;*/
     int i,j,j1, nc, ii, jj;
   pp=vector(1,nlstate);  
       for(i=1; i<= nlstate; i++){
   strcpy(fileresp,"p");        for(j=1; j<i;j++){
   strcat(fileresp,fileres);          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
   if((ficresp=fopen(fileresp,"w"))==NULL) {            /*s2 += param[i][j][nc]*cov[nc];*/
     printf("Problem with prevalence resultfile: %s\n", fileresp);            s2 += x[(i-1)*nlstate*ncovmodel+(j-1)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
     exit(0);  /*       printf("Int j<i s1=%.17e, s2=%.17e\n",s1,s2); */
   }          }
   freq= ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,agemin,agemax+3);          ps[i][j]=s2;
   j1=0;  /*      printf("s1=%.17e, s2=%.17e\n",s1,s2); */
         }
   j=cptcoveff;        for(j=i+1; j<=nlstate+ndeath;j++){
   if (cptcovn<1) {j=1;ncodemax[1]=1;}          for (nc=1, s2=0.;nc <=ncovmodel; nc++){
             s2 += x[(i-1)*nlstate*ncovmodel+(j-2)*ncovmodel+nc+(i-1)*(ndeath-1)*ncovmodel]*cov[nc];
   for(k1=1; k1<=j;k1++){  /*        printf("Int j>i s1=%.17e, s2=%.17e %lx %lx\n",s1,s2,s1,s2); */
    for(i1=1; i1<=ncodemax[k1];i1++){          }
        j1++;          ps[i][j]=s2;
         }
         for (i=-1; i<=nlstate+ndeath; i++)        }
          for (jk=-1; jk<=nlstate+ndeath; jk++)        /*ps[3][2]=1;*/
            for(m=agemin; m <= agemax+3; m++)      
              freq[i][jk][m]=0;      for(i=1; i<= nlstate; i++){
                s1=0;
        for (i=1; i<=imx; i++) {        for(j=1; j<i; j++)
          bool=1;          s1+=exp(ps[i][j]);
          if  (cptcovn>0) {        for(j=i+1; j<=nlstate+ndeath; j++)
            for (z1=1; z1<=cptcoveff; z1++)          s1+=exp(ps[i][j]);
              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) bool=0;        ps[i][i]=1./(s1+1.);
          }        for(j=1; j<i; j++)
           if (bool==1) {          ps[i][j]= exp(ps[i][j])*ps[i][i];
            for(m=firstpass; m<=lastpass-1; m++){        for(j=i+1; j<=nlstate+ndeath; j++)
              if(agev[m][i]==0) agev[m][i]=agemax+1;          ps[i][j]= exp(ps[i][j])*ps[i][i];
              if(agev[m][i]==1) agev[m][i]=agemax+2;        /* ps[i][nlstate+1]=1.-s1- ps[i][i];*/ /* Sum should be 1 */
              freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];      } /* end i */
              freq[s[m][i]][s[m+1][i]][(int) agemax+3] += weight[i];      
            }      for(ii=nlstate+1; ii<= nlstate+ndeath; ii++){
          }        for(jj=1; jj<= nlstate+ndeath; jj++){
        }          ps[ii][jj]=0;
         if  (cptcovn>0) {          ps[ii][ii]=1;
          fprintf(ficresp, "\n#********** Variable ");        }
          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);      }
        }      
        fprintf(ficresp, "**********\n#");  
        for(i=1; i<=nlstate;i++)  /*        for(ii=1; ii<= nlstate+ndeath; ii++){ */
          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);  /*       for(jj=1; jj<= nlstate+ndeath; jj++){ */
        fprintf(ficresp, "\n");  /*         printf("ddd %lf ",ps[ii][jj]); */
          /*       } */
   for(i=(int)agemin; i <= (int)agemax+3; i++){  /*       printf("\n "); */
     if(i==(int)agemax+3)  /*        } */
       printf("Total");  /*        printf("\n ");printf("%lf ",cov[2]); */
     else         /*
       printf("Age %d", i);        for(i=1; i<= npar; i++) printf("%f ",x[i]);
     for(jk=1; jk <=nlstate ; jk++){        goto end;*/
       for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)      return ps;
         pp[jk] += freq[jk][m][i];  }
     }  
     for(jk=1; jk <=nlstate ; jk++){  /**************** Product of 2 matrices ******************/
       for(m=-1, pos=0; m <=0 ; m++)  
         pos += freq[jk][m][i];  double **matprod2(double **out, double **in,long nrl, long nrh, long ncl, long nch, long ncolol, long ncoloh, double **b)
       if(pp[jk]>=1.e-10)  {
         printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);    /* Computes the matrix product of in(1,nrh-nrl+1)(1,nch-ncl+1) times
       else       b(1,nch-ncl+1)(1,ncoloh-ncolol+1) into out(...) */
         printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);    /* in, b, out are matrice of pointers which should have been initialized 
     }       before: only the contents of out is modified. The function returns
     for(jk=1; jk <=nlstate ; jk++){       a pointer to pointers identical to out */
       for(m=1, pp[jk]=0; m <=nlstate+ndeath; m++)    long i, j, k;
         pp[jk] += freq[jk][m][i];    for(i=nrl; i<= nrh; i++)
     }      for(k=ncolol; k<=ncoloh; k++)
     for(jk=1,pos=0; jk <=nlstate ; jk++)        for(j=ncl,out[i][k]=0.; j<=nch; j++)
       pos += pp[jk];          out[i][k] +=in[i][j]*b[j][k];
     for(jk=1; jk <=nlstate ; jk++){  
       if(pos>=1.e-5)    return out;
         printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);  }
       else  
         printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);  
       if( i <= (int) agemax){  /************* Higher Matrix Product ***************/
         if(pos>=1.e-5)  
           fprintf(ficresp," %d %.5f %.0f %.0f",i,pp[jk]/pos, pp[jk],pos);  double ***hpxij(double ***po, int nhstepm, double age, int hstepm, double *x, int nlstate, int stepm, double **oldm, double **savm, int ij )
       else  {
           fprintf(ficresp," %d NaNq %.0f %.0f",i,pp[jk],pos);    /* Computes the transition matrix starting at age 'age' over 
       }       'nhstepm*hstepm*stepm' months (i.e. until
     }       age (in years)  age+nhstepm*hstepm*stepm/12) by multiplying 
     for(jk=-1; jk <=nlstate+ndeath; jk++)       nhstepm*hstepm matrices. 
       for(m=-1; m <=nlstate+ndeath; m++)       Output is stored in matrix po[i][j][h] for h every 'hstepm' step 
         if(freq[jk][m][i] !=0 ) printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);       (typically every 2 years instead of every month which is too big 
     if(i <= (int) agemax)       for the memory).
       fprintf(ficresp,"\n");       Model is determined by parameters x and covariates have to be 
     printf("\n");       included manually here. 
     }  
     }       */
  }  
      int i, j, d, h, k;
   fclose(ficresp);    double **out, cov[NCOVMAX];
   free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath,(int) agemin,(int) agemax+3);    double **newm;
   free_vector(pp,1,nlstate);  
     /* Hstepm could be zero and should return the unit matrix */
 }  /* End of Freq */    for (i=1;i<=nlstate+ndeath;i++)
       for (j=1;j<=nlstate+ndeath;j++){
 /************* Waves Concatenation ***************/        oldm[i][j]=(i==j ? 1.0 : 0.0);
         po[i][j][0]=(i==j ? 1.0 : 0.0);
 void  concatwav(int wav[], int **dh, int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)      }
 {    /* Even if hstepm = 1, at least one multiplication by the unit matrix */
   /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.    for(h=1; h <=nhstepm; h++){
      Death is a valid wave (if date is known).      for(d=1; d <=hstepm; d++){
      mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i        newm=savm;
      dh[m][i] of dh[mw[mi][i][i] is the delay between two effective waves m=mw[mi][i]        /* Covariates have to be included here again */
      and mw[mi+1][i]. dh depends on stepm.        cov[1]=1.;
      */        cov[2]=age+((h-1)*hstepm + (d-1))*stepm/YEARM;
         for (k=1; k<=cptcovn;k++) cov[2+k]=nbcode[Tvar[k]][codtab[ij][Tvar[k]]];
   int i, mi, m;        for (k=1; k<=cptcovage;k++)
   int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;          cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
 float sum=0.;        for (k=1; k<=cptcovprod;k++)
           cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
   for(i=1; i<=imx; i++){  
     mi=0;  
     m=firstpass;        /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/
     while(s[m][i] <= nlstate){        /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/
       if(s[m][i]>=1)        out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, 
         mw[++mi][i]=m;                     pmij(pmmij,cov,ncovmodel,x,nlstate));
       if(m >=lastpass)        savm=oldm;
         break;        oldm=newm;
       else      }
         m++;      for(i=1; i<=nlstate+ndeath; i++)
     }/* end while */        for(j=1;j<=nlstate+ndeath;j++) {
     if (s[m][i] > nlstate){          po[i][j][h]=newm[i][j];
       mi++;     /* Death is another wave */          /*printf("i=%d j=%d h=%d po[i][j][h]=%f ",i,j,h,po[i][j][h]);
       /* if(mi==0)  never been interviewed correctly before death */           */
          /* Only death is a correct wave */        }
       mw[mi][i]=m;    } /* end h */
     }    return po;
   }
     wav[i]=mi;  
     if(mi==0)  
       printf("Warning, no any valid information for:%d line=%d\n",num[i],i);  /*************** log-likelihood *************/
   }  double func( double *x)
   {
   for(i=1; i<=imx; i++){    int i, ii, j, k, mi, d, kk;
     for(mi=1; mi<wav[i];mi++){    double l, ll[NLSTATEMAX], cov[NCOVMAX];
       if (stepm <=0)    double **out;
         dh[mi][i]=1;    double sw; /* Sum of weights */
       else{    double lli; /* Individual log likelihood */
         if (s[mw[mi+1][i]][i] > nlstate) {    int s1, s2;
           j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12);    double bbh, survp;
           if(j=0) j=1;  /* Survives at least one month after exam */    long ipmx;
         }    /*extern weight */
         else{    /* We are differentiating ll according to initial status */
           j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));    /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
           k=k+1;    /*for(i=1;i<imx;i++) 
           if (j >= jmax) jmax=j;      printf(" %d\n",s[4][i]);
           else if (j <= jmin)jmin=j;    */
           sum=sum+j;    cov[1]=1.;
         }  
         jk= j/stepm;    for(k=1; k<=nlstate; k++) ll[k]=0.;
         jl= j -jk*stepm;  
         ju= j -(jk+1)*stepm;    if(mle==1){
         if(jl <= -ju)      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
           dh[mi][i]=jk;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
         else        for(mi=1; mi<= wav[i]-1; mi++){
           dh[mi][i]=jk+1;          for (ii=1;ii<=nlstate+ndeath;ii++)
         if(dh[mi][i]==0)            for (j=1;j<=nlstate+ndeath;j++){
           dh[mi][i]=1; /* At least one step */              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
       }              savm[ii][j]=(ii==j ? 1.0 : 0.0);
     }            }
   }          for(d=0; d<dh[mi][i]; d++){
   printf("Delay (in months) between two waves Min=%d Max=%d Mean=%f\n\n ",jmin, jmax,sum/k);            newm=savm;
 }            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
 /*********** Tricode ****************************/            for (kk=1; kk<=cptcovage;kk++) {
 void tricode(int *Tvar, int **nbcode, int imx)              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
 {            }
   int Ndum[20],ij=1, k, j, i;            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   int cptcode=0;                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   cptcoveff=0;            savm=oldm;
              oldm=newm;
   for (k=0; k<19; k++) Ndum[k]=0;          } /* end mult */
   for (k=1; k<=7; k++) ncodemax[k]=0;        
           /*lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]);*/ /* Original formula */
   for (j=1; j<=(cptcovn+2*cptcovprod); j++) {          /* But now since version 0.9 we anticipate for bias at large stepm.
     for (i=1; i<=imx; i++) {           * If stepm is larger than one month (smallest stepm) and if the exact delay 
       ij=(int)(covar[Tvar[j]][i]);           * (in months) between two waves is not a multiple of stepm, we rounded to 
       Ndum[ij]++;           * the nearest (and in case of equal distance, to the lowest) interval but now
       if (ij > cptcode) cptcode=ij;           * we keep into memory the bias bh[mi][i] and also the previous matrix product
     }           * (i.e to dh[mi][i]-1) saved in 'savm'. Then we inter(extra)polate the
            * probability in order to take into account the bias as a fraction of the way
     /*printf("cptcode=%d cptcovn=%d ",cptcode,cptcovn);*/           * from savm to out if bh is negative or even beyond if bh is positive. bh varies
     for (i=0; i<=cptcode; i++) {           * -stepm/2 to stepm/2 .
       if(Ndum[i]!=0) ncodemax[j]++;           * For stepm=1 the results are the same as for previous versions of Imach.
     }           * For stepm > 1 the results are less biased than in previous versions. 
     ij=1;           */
           s1=s[mw[mi][i]][i];
     for (i=1; i<=ncodemax[j]; i++) {          s2=s[mw[mi+1][i]][i];
       for (k=0; k<=19; k++) {          bbh=(double)bh[mi][i]/(double)stepm; 
         if (Ndum[k] != 0) {          /* bias bh is positive if real duration
           nbcode[Tvar[j]][ij]=k;           * is higher than the multiple of stepm and negative otherwise.
           /*   printf("ij=%d ",nbcode[Tvar[2]][1]);*/           */
           ij++;          /* lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2]));*/
         }          if( s2 > nlstate){ 
         if (ij > ncodemax[j]) break;            /* i.e. if s2 is a death state and if the date of death is known 
       }                 then the contribution to the likelihood is the probability to 
     }               die between last step unit time and current  step unit time, 
   }                 which is also equal to probability to die before dh 
  for (i=1; i<=10; i++) {               minus probability to die before dh-stepm . 
       ij=Tvar[i];               In version up to 0.92 likelihood was computed
       Ndum[ij]++;          as if date of death was unknown. Death was treated as any other
     }          health state: the date of the interview describes the actual state
  ij=1;          and not the date of a change in health state. The former idea was
  for (i=1; i<=cptcovn; i++) {          to consider that at each interview the state was recorded
    if((Ndum[i]!=0) && (i<=ncov)){          (healthy, disable or death) and IMaCh was corrected; but when we
      Tvaraff[i]=ij;          introduced the exact date of death then we should have modified
    ij++;          the contribution of an exact death to the likelihood. This new
    }          contribution is smaller and very dependent of the step unit
  }          stepm. It is no more the probability to die between last interview
            and month of death but the probability to survive from last
  for (j=1; j<=(cptcovn+2*cptcovprod); j++) {          interview up to one month before death multiplied by the
    if ((Tvar[j]>= cptcoveff) && (Tvar[j] <=ncov)) cptcoveff=Tvar[j];          probability to die within a month. Thanks to Chris
    /*printf("j=%d %d\n",j,Tvar[j]);*/          Jackson for correcting this bug.  Former versions increased
  }          mortality artificially. The bad side is that we add another loop
            which slows down the processing. The difference can be up to 10%
  /* printf("cptcoveff=%d Tvaraff=%d %d\n",cptcoveff, Tvaraff[1],Tvaraff[2]);          lower mortality.
     scanf("%d",i);*/            */
 }            lli=log(out[s1][s2] - savm[s1][s2]);
   
 /*********** Health Expectancies ****************/  
           } else if  (s2==-2) {
 void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int ij)            for (j=1,survp=0. ; j<=nlstate; j++) 
 {              survp += out[s1][j];
   /* Health expectancies */            lli= survp;
   int i, j, nhstepm, hstepm, h;          }
   double age, agelim,hf;          
   double ***p3mat;          else if  (s2==-4) {
              for (j=3,survp=0. ; j<=nlstate; j++) 
   fprintf(ficreseij,"# Health expectancies\n");              survp += out[s1][j];
   fprintf(ficreseij,"# Age");            lli= survp;
   for(i=1; i<=nlstate;i++)          }
     for(j=1; j<=nlstate;j++)          
       fprintf(ficreseij," %1d-%1d",i,j);          else if  (s2==-5) {
   fprintf(ficreseij,"\n");            for (j=1,survp=0. ; j<=2; j++) 
               survp += out[s1][j];
   hstepm=1*YEARM; /*  Every j years of age (in month) */            lli= survp;
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */          }
   
   agelim=AGESUP;  
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */          else{
     /* nhstepm age range expressed in number of stepm */            lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
     nhstepm=(int) rint((agelim-age)*YEARM/stepm);            /*  lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2]));*/ /* linear interpolation */
     /* Typically if 20 years = 20*12/6=40 stepm */          } 
     if (stepm >= YEARM) hstepm=1;          /*lli=(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]);*/
     nhstepm = nhstepm/hstepm;/* Expressed in hstepm, typically 40/4=10 */          /*if(lli ==000.0)*/
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          /*printf("bbh= %f lli=%f savm=%f out=%f %d\n",bbh,lli,savm[s1][s2], out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]],i); */
     /* Computed by stepm unit matrices, product of hstepm matrices, stored          ipmx +=1;
        in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */          sw += weight[i];
     hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, ij);            ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
         } /* end of wave */
       } /* end of individual */
     for(i=1; i<=nlstate;i++)    }  else if(mle==2){
       for(j=1; j<=nlstate;j++)      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
         for (h=0, eij[i][j][(int)age]=0; h<=nhstepm; h++){        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
           eij[i][j][(int)age] +=p3mat[i][j][h];        for(mi=1; mi<= wav[i]-1; mi++){
         }          for (ii=1;ii<=nlstate+ndeath;ii++)
                for (j=1;j<=nlstate+ndeath;j++){
     hf=1;              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     if (stepm >= YEARM) hf=stepm/YEARM;              savm[ii][j]=(ii==j ? 1.0 : 0.0);
     fprintf(ficreseij,"%.0f",age );            }
     for(i=1; i<=nlstate;i++)          for(d=0; d<=dh[mi][i]; d++){
       for(j=1; j<=nlstate;j++){            newm=savm;
         fprintf(ficreseij," %.4f", hf*eij[i][j][(int)age]);            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
       }            for (kk=1; kk<=cptcovage;kk++) {
     fprintf(ficreseij,"\n");              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);            }
   }            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
 }                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
             savm=oldm;
 /************ Variance ******************/            oldm=newm;
 void varevsij(char fileres[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)          } /* end mult */
 {        
   /* Variance of health expectancies */          s1=s[mw[mi][i]][i];
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/          s2=s[mw[mi+1][i]][i];
   double **newm;          bbh=(double)bh[mi][i]/(double)stepm; 
   double **dnewm,**doldm;          lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*(savm[s1][s2])):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
   int i, j, nhstepm, hstepm, h;          ipmx +=1;
   int k, cptcode;          sw += weight[i];
    double *xp;          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   double **gp, **gm;        } /* end of wave */
   double ***gradg, ***trgradg;      } /* end of individual */
   double ***p3mat;    }  else if(mle==3){  /* exponential inter-extrapolation */
   double age,agelim;      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
   int theta;        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
         for(mi=1; mi<= wav[i]-1; mi++){
    fprintf(ficresvij,"# Covariances of life expectancies\n");          for (ii=1;ii<=nlstate+ndeath;ii++)
   fprintf(ficresvij,"# Age");            for (j=1;j<=nlstate+ndeath;j++){
   for(i=1; i<=nlstate;i++)              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     for(j=1; j<=nlstate;j++)              savm[ii][j]=(ii==j ? 1.0 : 0.0);
       fprintf(ficresvij," Cov(e%1d, e%1d)",i,j);            }
   fprintf(ficresvij,"\n");          for(d=0; d<dh[mi][i]; d++){
             newm=savm;
   xp=vector(1,npar);            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
   dnewm=matrix(1,nlstate,1,npar);            for (kk=1; kk<=cptcovage;kk++) {
   doldm=matrix(1,nlstate,1,nlstate);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
              }
   hstepm=1*YEARM; /* Every year of age */            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
   agelim = AGESUP;            savm=oldm;
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */            oldm=newm;
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */          } /* end mult */
     if (stepm >= YEARM) hstepm=1;        
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */          s1=s[mw[mi][i]][i];
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          s2=s[mw[mi+1][i]][i];
     gradg=ma3x(0,nhstepm,1,npar,1,nlstate);          bbh=(double)bh[mi][i]/(double)stepm; 
     gp=matrix(0,nhstepm,1,nlstate);          lli= (savm[s1][s2]>1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
     gm=matrix(0,nhstepm,1,nlstate);          ipmx +=1;
           sw += weight[i];
     for(theta=1; theta <=npar; theta++){          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
       for(i=1; i<=npar; i++){ /* Computes gradient */        } /* end of wave */
         xp[i] = x[i] + (i==theta ?delti[theta]:0);      } /* end of individual */
       }    }else if (mle==4){  /* ml=4 no inter-extrapolation */
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);        for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
       for(j=1; j<= nlstate; j++){        for(mi=1; mi<= wav[i]-1; mi++){
         for(h=0; h<=nhstepm; h++){          for (ii=1;ii<=nlstate+ndeath;ii++)
           for(i=1, gp[h][j]=0.;i<=nlstate;i++)            for (j=1;j<=nlstate+ndeath;j++){
             gp[h][j] += prlim[i][i]*p3mat[i][j][h];              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
         }              savm[ii][j]=(ii==j ? 1.0 : 0.0);
       }            }
              for(d=0; d<dh[mi][i]; d++){
       for(i=1; i<=npar; i++) /* Computes gradient */            newm=savm;
         xp[i] = x[i] - (i==theta ?delti[theta]:0);            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
       hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);              for (kk=1; kk<=cptcovage;kk++) {
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       for(j=1; j<= nlstate; j++){            }
         for(h=0; h<=nhstepm; h++){          
           for(i=1, gm[h][j]=0.;i<=nlstate;i++)            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
             gm[h][j] += prlim[i][i]*p3mat[i][j][h];                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
         }            savm=oldm;
       }            oldm=newm;
       for(j=1; j<= nlstate; j++)          } /* end mult */
         for(h=0; h<=nhstepm; h++){        
           gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];          s1=s[mw[mi][i]][i];
         }          s2=s[mw[mi+1][i]][i];
     } /* End theta */          if( s2 > nlstate){ 
             lli=log(out[s1][s2] - savm[s1][s2]);
     trgradg =ma3x(0,nhstepm,1,nlstate,1,npar);          }else{
             lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
     for(h=0; h<=nhstepm; h++)          }
       for(j=1; j<=nlstate;j++)          ipmx +=1;
         for(theta=1; theta <=npar; theta++)          sw += weight[i];
           trgradg[h][j][theta]=gradg[h][theta][j];          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
   /*      printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
     for(i=1;i<=nlstate;i++)        } /* end of wave */
       for(j=1;j<=nlstate;j++)      } /* end of individual */
         vareij[i][j][(int)age] =0.;    }else{  /* ml=5 no inter-extrapolation no jackson =0.8a */
     for(h=0;h<=nhstepm;h++){      for (i=1,ipmx=0, sw=0.; i<=imx; i++){
       for(k=0;k<=nhstepm;k++){        for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
         matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);        for(mi=1; mi<= wav[i]-1; mi++){
         matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);          for (ii=1;ii<=nlstate+ndeath;ii++)
         for(i=1;i<=nlstate;i++)            for (j=1;j<=nlstate+ndeath;j++){
           for(j=1;j<=nlstate;j++)              oldm[ii][j]=(ii==j ? 1.0 : 0.0);
             vareij[i][j][(int)age] += doldm[i][j];              savm[ii][j]=(ii==j ? 1.0 : 0.0);
       }            }
     }          for(d=0; d<dh[mi][i]; d++){
     h=1;            newm=savm;
     if (stepm >= YEARM) h=stepm/YEARM;            cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
     fprintf(ficresvij,"%.0f ",age );            for (kk=1; kk<=cptcovage;kk++) {
     for(i=1; i<=nlstate;i++)              cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       for(j=1; j<=nlstate;j++){            }
         fprintf(ficresvij," %.4f", h*vareij[i][j][(int)age]);          
       }            out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
     fprintf(ficresvij,"\n");                         1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
     free_matrix(gp,0,nhstepm,1,nlstate);            savm=oldm;
     free_matrix(gm,0,nhstepm,1,nlstate);            oldm=newm;
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);          } /* end mult */
     free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);        
     free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);          s1=s[mw[mi][i]][i];
   } /* End age */          s2=s[mw[mi+1][i]][i];
            lli=log(out[s[mw[mi][i]][i]][s[mw[mi+1][i]][i]]); /* Original formula */
   free_vector(xp,1,npar);          ipmx +=1;
   free_matrix(doldm,1,nlstate,1,npar);          sw += weight[i];
   free_matrix(dnewm,1,nlstate,1,nlstate);          ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
           /*printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]);*/
 }        } /* end of wave */
       } /* end of individual */
 /************ Variance of prevlim ******************/    } /* End of if */
 void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij)    for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
 {    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
   /* Variance of prevalence limit */    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
   /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/    return -l;
   double **newm;  }
   double **dnewm,**doldm;  
   int i, j, nhstepm, hstepm;  /*************** log-likelihood *************/
   int k, cptcode;  double funcone( double *x)
   double *xp;  {
   double *gp, *gm;    /* Same as likeli but slower because of a lot of printf and if */
   double **gradg, **trgradg;    int i, ii, j, k, mi, d, kk;
   double age,agelim;    double l, ll[NLSTATEMAX], cov[NCOVMAX];
   int theta;    double **out;
        double lli; /* Individual log likelihood */
   fprintf(ficresvpl,"# Standard deviation of prevalences limit\n");    double llt;
   fprintf(ficresvpl,"# Age");    int s1, s2;
   for(i=1; i<=nlstate;i++)    double bbh, survp;
       fprintf(ficresvpl," %1d-%1d",i,i);    /*extern weight */
   fprintf(ficresvpl,"\n");    /* We are differentiating ll according to initial status */
     /*  for (i=1;i<=npar;i++) printf("%f ", x[i]);*/
   xp=vector(1,npar);    /*for(i=1;i<imx;i++) 
   dnewm=matrix(1,nlstate,1,npar);      printf(" %d\n",s[4][i]);
   doldm=matrix(1,nlstate,1,nlstate);    */
      cov[1]=1.;
   hstepm=1*YEARM; /* Every year of age */  
   hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */    for(k=1; k<=nlstate; k++) ll[k]=0.;
   agelim = AGESUP;  
   for (age=bage; age<=fage; age ++){ /* If stepm=6 months */    for (i=1,ipmx=0, sw=0.; i<=imx; i++){
     nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */      for (k=1; k<=cptcovn;k++) cov[2+k]=covar[Tvar[k]][i];
     if (stepm >= YEARM) hstepm=1;      for(mi=1; mi<= wav[i]-1; mi++){
     nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */        for (ii=1;ii<=nlstate+ndeath;ii++)
     gradg=matrix(1,npar,1,nlstate);          for (j=1;j<=nlstate+ndeath;j++){
     gp=vector(1,nlstate);            oldm[ii][j]=(ii==j ? 1.0 : 0.0);
     gm=vector(1,nlstate);            savm[ii][j]=(ii==j ? 1.0 : 0.0);
           }
     for(theta=1; theta <=npar; theta++){        for(d=0; d<dh[mi][i]; d++){
       for(i=1; i<=npar; i++){ /* Computes gradient */          newm=savm;
         xp[i] = x[i] + (i==theta ?delti[theta]:0);          cov[2]=agev[mw[mi][i]][i]+d*stepm/YEARM;
       }          for (kk=1; kk<=cptcovage;kk++) {
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);            cov[Tage[kk]+2]=covar[Tvar[Tage[kk]]][i]*cov[2];
       for(i=1;i<=nlstate;i++)          }
         gp[i] = prlim[i][i];          out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,
                           1,nlstate+ndeath,pmij(pmmij,cov,ncovmodel,x,nlstate));
       for(i=1; i<=npar; i++) /* Computes gradient */          savm=oldm;
         xp[i] = x[i] - (i==theta ?delti[theta]:0);          oldm=newm;
       prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);        } /* end mult */
       for(i=1;i<=nlstate;i++)        
         gm[i] = prlim[i][i];        s1=s[mw[mi][i]][i];
         s2=s[mw[mi+1][i]][i];
       for(i=1;i<=nlstate;i++)        bbh=(double)bh[mi][i]/(double)stepm; 
         gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];        /* bias is positive if real duration
     } /* End theta */         * is higher than the multiple of stepm and negative otherwise.
          */
     trgradg =matrix(1,nlstate,1,npar);        if( s2 > nlstate && (mle <5) ){  /* Jackson */
           lli=log(out[s1][s2] - savm[s1][s2]);
     for(j=1; j<=nlstate;j++)        } else if (mle==1){
       for(theta=1; theta <=npar; theta++)          lli= log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]); /* linear interpolation */
         trgradg[j][theta]=gradg[theta][j];        } else if(mle==2){
           lli= (savm[s1][s2]>(double)1.e-8 ?log((1.+bbh)*out[s1][s2]- bbh*savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* linear interpolation */
     for(i=1;i<=nlstate;i++)        } else if(mle==3){  /* exponential inter-extrapolation */
       varpl[i][(int)age] =0.;          lli= (savm[s1][s2]>(double)1.e-8 ?(1.+bbh)*log(out[s1][s2])- bbh*log(savm[s1][s2]):log((1.+bbh)*out[s1][s2])); /* exponential inter-extrapolation */
     matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);        } else if (mle==4){  /* mle=4 no inter-extrapolation */
     matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);          lli=log(out[s1][s2]); /* Original formula */
     for(i=1;i<=nlstate;i++)        } else{  /* ml>=5 no inter-extrapolation no jackson =0.8a */
       varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */          lli=log(out[s1][s2]); /* Original formula */
         } /* End of if */
     fprintf(ficresvpl,"%.0f ",age );        ipmx +=1;
     for(i=1; i<=nlstate;i++)        sw += weight[i];
       fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));        ll[s[mw[mi][i]][i]] += 2*weight[i]*lli;
     fprintf(ficresvpl,"\n");  /*       printf("i=%6d s1=%1d s2=%1d mi=%1d mw=%1d dh=%3d prob=%10.6f w=%6.4f out=%10.6f sav=%10.6f\n",i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],out[s1][s2],savm[s1][s2]); */
     free_vector(gp,1,nlstate);        if(globpr){
     free_vector(gm,1,nlstate);          fprintf(ficresilk,"%9d %6d %1d %1d %1d %1d %3d %10.6f %6.4f\
     free_matrix(gradg,1,npar,1,nlstate);   %10.6f %10.6f %10.6f ", \
     free_matrix(trgradg,1,nlstate,1,npar);                  num[i],i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],
   } /* End age */                  2*weight[i]*lli,out[s1][s2],savm[s1][s2]);
           for(k=1,llt=0.,l=0.; k<=nlstate; k++){
   free_vector(xp,1,npar);            llt +=ll[k]*gipmx/gsw;
   free_matrix(doldm,1,nlstate,1,npar);            fprintf(ficresilk," %10.6f",-ll[k]*gipmx/gsw);
   free_matrix(dnewm,1,nlstate,1,nlstate);          }
           fprintf(ficresilk," %10.6f\n", -llt);
 }        }
       } /* end of wave */
     } /* end of individual */
     for(k=1,l=0.; k<=nlstate; k++) l += ll[k];
 /***********************************************/    /* printf("l1=%f l2=%f ",ll[1],ll[2]); */
 /**************** Main Program *****************/    l= l*ipmx/sw; /* To get the same order of magnitude as if weight=1 for every body */
 /***********************************************/    if(globpr==0){ /* First time we count the contributions and weights */
       gipmx=ipmx;
 /*int main(int argc, char *argv[])*/      gsw=sw;
 int main()    }
 {    return -l;
   }
   int i,j, k, n=MAXN,iter,m,size,cptcode, aaa, cptcod;  
   double agedeb, agefin,hf;  
   double agemin=1.e20, agemax=-1.e20;  /*************** function likelione ***********/
   void likelione(FILE *ficres,double p[], int npar, int nlstate, int *globpri, long *ipmx, double *sw, double *fretone, double (*funcone)(double []))
   double fret;  {
   double **xi,tmp,delta;    /* This routine should help understanding what is done with 
        the selection of individuals/waves and
   double dum; /* Dummy variable */       to check the exact contribution to the likelihood.
   double ***p3mat;       Plotting could be done.
   int *indx;     */
   char line[MAXLINE], linepar[MAXLINE];    int k;
   char title[MAXLINE];  
   char optionfile[FILENAMELENGTH], datafile[FILENAMELENGTH],  filerespl[FILENAMELENGTH];    if(*globpri !=0){ /* Just counts and sums, no printings */
   char fileres[FILENAMELENGTH], filerespij[FILENAMELENGTH], filereso[FILENAMELENGTH];      strcpy(fileresilk,"ilk"); 
   char filerest[FILENAMELENGTH];      strcat(fileresilk,fileres);
   char fileregp[FILENAMELENGTH];      if((ficresilk=fopen(fileresilk,"w"))==NULL) {
   char path[80],pathc[80],pathcd[80],pathtot[80],model[20];        printf("Problem with resultfile: %s\n", fileresilk);
   int firstobs=1, lastobs=10;        fprintf(ficlog,"Problem with resultfile: %s\n", fileresilk);
   int sdeb, sfin; /* Status at beginning and end */      }
   int c,  h , cpt,l;      fprintf(ficresilk, "#individual(line's_record) s1 s2 wave# effective_wave# number_of_matrices_product pij weight -2ln(pij)*weight 0pij_x 0pij_(x-stepm) cumulating_loglikeli_by_health_state(reweighted=-2ll*weightXnumber_of_contribs/sum_of_weights) and_total\n");
   int ju,jl, mi;      fprintf(ficresilk, "#num_i i s1 s2 mi mw dh likeli weight 2wlli out sav ");
   int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;      /*  i,s1,s2,mi,mw[mi][i],dh[mi][i],exp(lli),weight[i],2*weight[i]*lli,out[s1][s2],savm[s1][s2]); */
   int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,**adl,*tab;      for(k=1; k<=nlstate; k++) 
          fprintf(ficresilk," -2*gipw/gsw*weight*ll[%d]++",k);
   int hstepm, nhstepm;      fprintf(ficresilk," -2*gipw/gsw*weight*ll(total)\n");
   double bage, fage, age, agelim, agebase;    }
   double ftolpl=FTOL;  
   double **prlim;    *fretone=(*funcone)(p);
   double *severity;    if(*globpri !=0){
   double ***param; /* Matrix of parameters */      fclose(ficresilk);
   double  *p;      fprintf(fichtm,"\n<br>File of contributions to the likelihood: <a href=\"%s\">%s</a><br>\n",subdirf(fileresilk),subdirf(fileresilk));
   double **matcov; /* Matrix of covariance */      fflush(fichtm); 
   double ***delti3; /* Scale */    } 
   double *delti; /* Scale */    return;
   double ***eij, ***vareij;  }
   double **varpl; /* Variances of prevalence limits by age */  
   double *epj, vepp;  
   char version[80]="Imach version 62c, May 1999, INED-EUROREVES ";  /*********** Maximum Likelihood Estimation ***************/
   char *alph[]={"a","a","b","c","d","e"}, str[4];  
   void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double []))
   char z[1]="c", occ;  {
 #include <sys/time.h>    int i,j, iter;
 #include <time.h>    double **xi;
   char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];    double fret;
   /* long total_usecs;    double fretone; /* Only one call to likelihood */
   struct timeval start_time, end_time;    /*  char filerespow[FILENAMELENGTH];*/
      xi=matrix(1,npar,1,npar);
   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */    for (i=1;i<=npar;i++)
       for (j=1;j<=npar;j++)
         xi[i][j]=(i==j ? 1.0 : 0.0);
   printf("\nIMACH, Version 0.64a");    printf("Powell\n");  fprintf(ficlog,"Powell\n");
   printf("\nEnter the parameter file name: ");    strcpy(filerespow,"pow"); 
     strcat(filerespow,fileres);
 #ifdef windows    if((ficrespow=fopen(filerespow,"w"))==NULL) {
   scanf("%s",pathtot);      printf("Problem with resultfile: %s\n", filerespow);
   getcwd(pathcd, size);      fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
   /*cygwin_split_path(pathtot,path,optionfile);    }
     printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/    fprintf(ficrespow,"# Powell\n# iter -2*LL");
   /* cutv(path,optionfile,pathtot,'\\');*/    for (i=1;i<=nlstate;i++)
       for(j=1;j<=nlstate+ndeath;j++)
 split(pathtot, path,optionfile);        if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
   chdir(path);    fprintf(ficrespow,"\n");
   replace(pathc,path);  
 #endif    powell(p,xi,npar,ftol,&iter,&fret,func);
 #ifdef unix  
   scanf("%s",optionfile);    free_matrix(xi,1,npar,1,npar);
 #endif    fclose(ficrespow);
     printf("\n#Number of iterations = %d, -2 Log likelihood = %.12f\n",iter,func(p));
 /*-------- arguments in the command line --------*/    fprintf(ficlog,"\n#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
     fprintf(ficres,"#Number of iterations = %d, -2 Log likelihood = %.12f \n",iter,func(p));
   strcpy(fileres,"r");  
   strcat(fileres, optionfile);  }
   
   /*---------arguments file --------*/  /**** Computes Hessian and covariance matrix ***/
   void hesscov(double **matcov, double p[], int npar, double delti[], double ftolhess, double (*func)(double []))
   if((ficpar=fopen(optionfile,"r"))==NULL)    {  {
     printf("Problem with optionfile %s\n",optionfile);    double  **a,**y,*x,pd;
     goto end;    double **hess;
   }    int i, j,jk;
     int *indx;
   strcpy(filereso,"o");  
   strcat(filereso,fileres);    double hessii(double p[], double delta, int theta, double delti[],double (*func)(double []),int npar);
   if((ficparo=fopen(filereso,"w"))==NULL) {    double hessij(double p[], double delti[], int i, int j,double (*func)(double []),int npar);
     printf("Problem with Output resultfile: %s\n", filereso);goto end;    void lubksb(double **a, int npar, int *indx, double b[]) ;
   }    void ludcmp(double **a, int npar, int *indx, double *d) ;
     double gompertz(double p[]);
   /* Reads comments: lines beginning with '#' */    hess=matrix(1,npar,1,npar);
   while((c=getc(ficpar))=='#' && c!= EOF){  
     ungetc(c,ficpar);    printf("\nCalculation of the hessian matrix. Wait...\n");
     fgets(line, MAXLINE, ficpar);    fprintf(ficlog,"\nCalculation of the hessian matrix. Wait...\n");
     puts(line);    for (i=1;i<=npar;i++){
     fputs(line,ficparo);      printf("%d",i);fflush(stdout);
   }      fprintf(ficlog,"%d",i);fflush(ficlog);
   ungetc(c,ficpar);     
        hess[i][i]=hessii(p,ftolhess,i,delti,func,npar);
   fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncov, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);      
   printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate,ndeath, maxwav, mle, weightopt,model);      /*  printf(" %f ",p[i]);
   fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncov,nlstate,ndeath,maxwav, mle, weightopt,model);          printf(" %lf %lf %lf",hess[i][i],ftolhess,delti[i]);*/
     }
   covar=matrix(0,NCOVMAX,1,n);        
   if (strlen(model)<=1) cptcovn=0;    for (i=1;i<=npar;i++) {
   else {      for (j=1;j<=npar;j++)  {
     j=0;        if (j>i) { 
     j=nbocc(model,'+');          printf(".%d%d",i,j);fflush(stdout);
     cptcovn=j+1;          fprintf(ficlog,".%d%d",i,j);fflush(ficlog);
   }          hess[i][j]=hessij(p,delti,i,j,func,npar);
           
   ncovmodel=2+cptcovn;          hess[j][i]=hess[i][j];    
   nvar=ncovmodel-1; /* Suppressing age as a basic covariate */          /*printf(" %lf ",hess[i][j]);*/
          }
   /* Read guess parameters */      }
   /* Reads comments: lines beginning with '#' */    }
   while((c=getc(ficpar))=='#' && c!= EOF){    printf("\n");
     ungetc(c,ficpar);    fprintf(ficlog,"\n");
     fgets(line, MAXLINE, ficpar);  
     puts(line);    printf("\nInverting the hessian to get the covariance matrix. Wait...\n");
     fputs(line,ficparo);    fprintf(ficlog,"\nInverting the hessian to get the covariance matrix. Wait...\n");
   }    
   ungetc(c,ficpar);    a=matrix(1,npar,1,npar);
      y=matrix(1,npar,1,npar);
   param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);    x=vector(1,npar);
     for(i=1; i <=nlstate; i++)    indx=ivector(1,npar);
     for(j=1; j <=nlstate+ndeath-1; j++){    for (i=1;i<=npar;i++)
       fscanf(ficpar,"%1d%1d",&i1,&j1);      for (j=1;j<=npar;j++) a[i][j]=hess[i][j];
       fprintf(ficparo,"%1d%1d",i1,j1);    ludcmp(a,npar,indx,&pd);
       printf("%1d%1d",i,j);  
       for(k=1; k<=ncovmodel;k++){    for (j=1;j<=npar;j++) {
         fscanf(ficpar," %lf",&param[i][j][k]);      for (i=1;i<=npar;i++) x[i]=0;
         printf(" %lf",param[i][j][k]);      x[j]=1;
         fprintf(ficparo," %lf",param[i][j][k]);      lubksb(a,npar,indx,x);
       }      for (i=1;i<=npar;i++){ 
       fscanf(ficpar,"\n");        matcov[i][j]=x[i];
       printf("\n");      }
       fprintf(ficparo,"\n");    }
     }  
      printf("\n#Hessian matrix#\n");
   npar= (nlstate+ndeath-1)*nlstate*ncovmodel;    fprintf(ficlog,"\n#Hessian matrix#\n");
   p=param[1][1];    for (i=1;i<=npar;i++) { 
        for (j=1;j<=npar;j++) { 
   /* Reads comments: lines beginning with '#' */        printf("%.3e ",hess[i][j]);
   while((c=getc(ficpar))=='#' && c!= EOF){        fprintf(ficlog,"%.3e ",hess[i][j]);
     ungetc(c,ficpar);      }
     fgets(line, MAXLINE, ficpar);      printf("\n");
     puts(line);      fprintf(ficlog,"\n");
     fputs(line,ficparo);    }
   }  
   ungetc(c,ficpar);    /* Recompute Inverse */
     for (i=1;i<=npar;i++)
   delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);      for (j=1;j<=npar;j++) a[i][j]=matcov[i][j];
   delti=vector(1,npar); /* Scale of each paramater (output from hesscov) */    ludcmp(a,npar,indx,&pd);
   for(i=1; i <=nlstate; i++){  
     for(j=1; j <=nlstate+ndeath-1; j++){    /*  printf("\n#Hessian matrix recomputed#\n");
       fscanf(ficpar,"%1d%1d",&i1,&j1);  
       printf("%1d%1d",i,j);    for (j=1;j<=npar;j++) {
       fprintf(ficparo,"%1d%1d",i1,j1);      for (i=1;i<=npar;i++) x[i]=0;
       for(k=1; k<=ncovmodel;k++){      x[j]=1;
         fscanf(ficpar,"%le",&delti3[i][j][k]);      lubksb(a,npar,indx,x);
         printf(" %le",delti3[i][j][k]);      for (i=1;i<=npar;i++){ 
         fprintf(ficparo," %le",delti3[i][j][k]);        y[i][j]=x[i];
       }        printf("%.3e ",y[i][j]);
       fscanf(ficpar,"\n");        fprintf(ficlog,"%.3e ",y[i][j]);
       printf("\n");      }
       fprintf(ficparo,"\n");      printf("\n");
     }      fprintf(ficlog,"\n");
   }    }
   delti=delti3[1][1];    */
    
   /* Reads comments: lines beginning with '#' */    free_matrix(a,1,npar,1,npar);
   while((c=getc(ficpar))=='#' && c!= EOF){    free_matrix(y,1,npar,1,npar);
     ungetc(c,ficpar);    free_vector(x,1,npar);
     fgets(line, MAXLINE, ficpar);    free_ivector(indx,1,npar);
     puts(line);    free_matrix(hess,1,npar,1,npar);
     fputs(line,ficparo);  
   }  
   ungetc(c,ficpar);  }
    
   matcov=matrix(1,npar,1,npar);  /*************** hessian matrix ****************/
   for(i=1; i <=npar; i++){  double hessii(double x[], double delta, int theta, double delti[], double (*func)(double []), int npar)
     fscanf(ficpar,"%s",&str);  {
     printf("%s",str);    int i;
     fprintf(ficparo,"%s",str);    int l=1, lmax=20;
     for(j=1; j <=i; j++){    double k1,k2;
       fscanf(ficpar," %le",&matcov[i][j]);    double p2[NPARMAX+1];
       printf(" %.5le",matcov[i][j]);    double res;
       fprintf(ficparo," %.5le",matcov[i][j]);    double delt=0.0001, delts, nkhi=10.,nkhif=1., khi=1.e-4;
     }    double fx;
     fscanf(ficpar,"\n");    int k=0,kmax=10;
     printf("\n");    double l1;
     fprintf(ficparo,"\n");  
   }    fx=func(x);
   for(i=1; i <=npar; i++)    for (i=1;i<=npar;i++) p2[i]=x[i];
     for(j=i+1;j<=npar;j++)    for(l=0 ; l <=lmax; l++){
       matcov[i][j]=matcov[j][i];      l1=pow(10,l);
          delts=delt;
   printf("\n");      for(k=1 ; k <kmax; k=k+1){
         delt = delta*(l1*k);
         p2[theta]=x[theta] +delt;
     /*-------- data file ----------*/        k1=func(p2)-fx;
     if((ficres =fopen(fileres,"w"))==NULL) {        p2[theta]=x[theta]-delt;
       printf("Problem with resultfile: %s\n", fileres);goto end;        k2=func(p2)-fx;
     }        /*res= (k1-2.0*fx+k2)/delt/delt; */
     fprintf(ficres,"#%s\n",version);        res= (k1+k2)/delt/delt/2.; /* Divided by because L and not 2*L */
            
     if((fic=fopen(datafile,"r"))==NULL)    {  #ifdef DEBUG
       printf("Problem with datafile: %s\n", datafile);goto end;        printf("%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
     }        fprintf(ficlog,"%d %d k1=%.12e k2=%.12e xk1=%.12e xk2=%.12e delt=%.12e res=%.12e l=%d k=%d,fx=%.12e\n",theta,theta,k1,k2,x[theta]+delt,x[theta]-delt,delt,res, l, k,fx);
   #endif
     n= lastobs;        /*if(fabs(k1-2.0*fx+k2) <1.e-13){ */
     severity = vector(1,maxwav);        if((k1 <khi/nkhi/2.) || (k2 <khi/nkhi/2.)){
     outcome=imatrix(1,maxwav+1,1,n);          k=kmax;
     num=ivector(1,n);        }
     moisnais=vector(1,n);        else if((k1 >khi/nkhif) || (k2 >khi/nkhif)){ /* Keeps lastvalue before 3.84/2 KHI2 5% 1d.f. */
     annais=vector(1,n);          k=kmax; l=lmax*10.;
     moisdc=vector(1,n);        }
     andc=vector(1,n);        else if((k1 >khi/nkhi) || (k2 >khi/nkhi)){ 
     agedc=vector(1,n);          delts=delt;
     cod=ivector(1,n);        }
     weight=vector(1,n);      }
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */    }
     mint=matrix(1,maxwav,1,n);    delti[theta]=delts;
     anint=matrix(1,maxwav,1,n);    return res; 
     s=imatrix(1,maxwav+1,1,n);    
     adl=imatrix(1,maxwav+1,1,n);      }
     tab=ivector(1,NCOVMAX);  
     ncodemax=ivector(1,8);  double hessij( double x[], double delti[], int thetai,int thetaj,double (*func)(double []),int npar)
   {
     i=1;    int i;
     while (fgets(line, MAXLINE, fic) != NULL)    {    int l=1, l1, lmax=20;
       if ((i >= firstobs) && (i <=lastobs)) {    double k1,k2,k3,k4,res,fx;
            double p2[NPARMAX+1];
         for (j=maxwav;j>=1;j--){    int k;
           cutv(stra, strb,line,' '); s[j][i]=atoi(strb);  
           strcpy(line,stra);    fx=func(x);
           cutv(stra, strb,line,'/'); anint[j][i]=(double)(atoi(strb)); strcpy(line,stra);    for (k=1; k<=2; k++) {
           cutv(stra, strb,line,' '); mint[j][i]=(double)(atoi(strb)); strcpy(line,stra);      for (i=1;i<=npar;i++) p2[i]=x[i];
         }      p2[thetai]=x[thetai]+delti[thetai]/k;
              p2[thetaj]=x[thetaj]+delti[thetaj]/k;
         cutv(stra, strb,line,'/'); andc[i]=(double)(atoi(strb)); strcpy(line,stra);      k1=func(p2)-fx;
         cutv(stra, strb,line,' '); moisdc[i]=(double)(atoi(strb)); strcpy(line,stra);    
       p2[thetai]=x[thetai]+delti[thetai]/k;
         cutv(stra, strb,line,'/'); annais[i]=(double)(atoi(strb)); strcpy(line,stra);      p2[thetaj]=x[thetaj]-delti[thetaj]/k;
         cutv(stra, strb,line,' '); moisnais[i]=(double)(atoi(strb)); strcpy(line,stra);      k2=func(p2)-fx;
     
         cutv(stra, strb,line,' '); weight[i]=(double)(atoi(strb)); strcpy(line,stra);      p2[thetai]=x[thetai]-delti[thetai]/k;
         for (j=ncov;j>=1;j--){      p2[thetaj]=x[thetaj]+delti[thetaj]/k;
           cutv(stra, strb,line,' '); covar[j][i]=(double)(atoi(strb)); strcpy(line,stra);      k3=func(p2)-fx;
         }    
         num[i]=atol(stra);      p2[thetai]=x[thetai]-delti[thetai]/k;
       p2[thetaj]=x[thetaj]-delti[thetaj]/k;
         /*printf("%d %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));*/      k4=func(p2)-fx;
       res=(k1-k2-k3+k4)/4.0/delti[thetai]*k/delti[thetaj]*k/2.; /* Because of L not 2*L */
         i=i+1;  #ifdef DEBUG
       }      printf("%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
     }      fprintf(ficlog,"%d %d k=%d, k1=%.12e k2=%.12e k3=%.12e k4=%.12e delti/k=%.12e deltj/k=%.12e, xi-de/k=%.12e xj-de/k=%.12e  res=%.12e k1234=%.12e,k1-2=%.12e,k3-4=%.12e\n",thetai,thetaj,k,k1,k2,k3,k4,delti[thetai]/k,delti[thetaj]/k,x[thetai]-delti[thetai]/k,x[thetaj]-delti[thetaj]/k, res,k1-k2-k3+k4,k1-k2,k3-k4);
   #endif
     /*scanf("%d",i);*/    }
   imx=i-1; /* Number of individuals */    return res;
   }
   /* Calculation of the number of parameter from char model*/  
   Tvar=ivector(1,15);  /************** Inverse of matrix **************/
   Tprod=ivector(1,15);  void ludcmp(double **a, int n, int *indx, double *d) 
   Tvaraff=ivector(1,15);  { 
   Tvard=imatrix(1,15,1,2);    int i,imax,j,k; 
   Tage=ivector(1,15);          double big,dum,sum,temp; 
        double *vv; 
   if (strlen(model) >1){   
     j=0, j1=0, k1=1, k2=1;    vv=vector(1,n); 
     j=nbocc(model,'+');    *d=1.0; 
     j1=nbocc(model,'*');    for (i=1;i<=n;i++) { 
     cptcovn=j+1;      big=0.0; 
     cptcovprod=j1;      for (j=1;j<=n;j++) 
            if ((temp=fabs(a[i][j])) > big) big=temp; 
     strcpy(modelsav,model);      if (big == 0.0) nrerror("Singular matrix in routine ludcmp"); 
    if (j==0) {      vv[i]=1.0/big; 
       if (j1==0){    } 
         cutv(stra,strb,modelsav,'V');    for (j=1;j<=n;j++) { 
         Tvar[1]=atoi(strb);      for (i=1;i<j;i++) { 
       }        sum=a[i][j]; 
       else if (j1==1) {        for (k=1;k<i;k++) sum -= a[i][k]*a[k][j]; 
         cutv(stra,strb,modelsav,'*');        a[i][j]=sum; 
         Tage[1]=1; cptcovage++;      } 
         if (strcmp(stra,"age")==0) {      big=0.0; 
           cptcovprod--;      for (i=j;i<=n;i++) { 
           cutv(strd,strc,strb,'V');        sum=a[i][j]; 
           Tvar[1]=atoi(strc);        for (k=1;k<j;k++) 
         }          sum -= a[i][k]*a[k][j]; 
         else if (strcmp(strb,"age")==0) {        a[i][j]=sum; 
           cptcovprod--;        if ( (dum=vv[i]*fabs(sum)) >= big) { 
           cutv(strd,strc,stra,'V');          big=dum; 
           Tvar[1]=atoi(strc);          imax=i; 
         }        } 
         else {      } 
           cutv(strd,strc,strb,'V');      if (j != imax) { 
           cutv(stre,strd,stra,'V');        for (k=1;k<=n;k++) { 
           Tvar[1]=ncov+1;          dum=a[imax][k]; 
           for (k=1; k<=lastobs;k++)          a[imax][k]=a[j][k]; 
               covar[ncov+1][k]=covar[atoi(strc)][k]*covar[atoi(strd)][k];          a[j][k]=dum; 
         }        } 
         /*printf("%s %s %s\n", stra,strb,modelsav);        *d = -(*d); 
 printf("%d ",Tvar[1]);        vv[imax]=vv[j]; 
 scanf("%d",i);*/      } 
       }      indx[j]=imax; 
     }      if (a[j][j] == 0.0) a[j][j]=TINY; 
    else {      if (j != n) { 
       for(i=j; i>=1;i--){        dum=1.0/(a[j][j]); 
         cutv(stra,strb,modelsav,'+');        for (i=j+1;i<=n;i++) a[i][j] *= dum; 
         /*printf("%s %s %s\n", stra,strb,modelsav);      } 
           scanf("%d",i);*/    } 
         if (strchr(strb,'*')) {    free_vector(vv,1,n);  /* Doesn't work */
           cutv(strd,strc,strb,'*');  ;
           if (strcmp(strc,"age")==0) {  } 
             cptcovprod--;  
             cutv(strb,stre,strd,'V');  void lubksb(double **a, int n, int *indx, double b[]) 
             Tvar[i+1]=atoi(stre);  { 
             cptcovage++;    int i,ii=0,ip,j; 
             Tage[cptcovage]=i+1;    double sum; 
             printf("stre=%s ", stre);   
           }    for (i=1;i<=n;i++) { 
           else if (strcmp(strd,"age")==0) {      ip=indx[i]; 
             cptcovprod--;      sum=b[ip]; 
             cutv(strb,stre,strc,'V');      b[ip]=b[i]; 
             Tvar[i+1]=atoi(stre);      if (ii) 
             cptcovage++;        for (j=ii;j<=i-1;j++) sum -= a[i][j]*b[j]; 
             Tage[cptcovage]=i+1;      else if (sum) ii=i; 
           }      b[i]=sum; 
           else {    } 
             cutv(strb,stre,strc,'V');    for (i=n;i>=1;i--) { 
             Tvar[i+1]=ncov+k1;      sum=b[i]; 
             cutv(strb,strc,strd,'V');      for (j=i+1;j<=n;j++) sum -= a[i][j]*b[j]; 
             Tprod[k1]=i+1;      b[i]=sum/a[i][i]; 
             Tvard[k1][1]=atoi(strc);    } 
             Tvard[k1][2]=atoi(stre);  } 
             Tvar[cptcovn+k2]=Tvard[k1][1];  
             Tvar[cptcovn+k2+1]=Tvard[k1][2];  void pstamp(FILE *fichier)
             for (k=1; k<=lastobs;k++)  {
               covar[ncov+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];    fprintf(fichier,"# %s.%s\n#%s\n#%s\n# %s", optionfilefiname,optionfilext,version,fullversion,strstart);
             k1++;  }
             k2=k2+2;  
           }  /************ Frequencies ********************/
         }  void  freqsummary(char fileres[], int iagemin, int iagemax, int **s, double **agev, int nlstate, int imx, int *Tvaraff, int **nbcode, int *ncodemax,double **mint,double **anint, char strstart[])
         else {  {  /* Some frequencies */
           cutv(strd,strc,strb,'V');    
           /* printf("%s %s %s", strd,strc,strb);*/    int i, m, jk, k1,i1, j1, bool, z1,z2,j;
           Tvar[i+1]=atoi(strc);    int first;
         }    double ***freq; /* Frequencies */
         strcpy(modelsav,stra);      double *pp, **prop;
       }    double pos,posprop, k2, dateintsum=0,k2cpt=0;
       cutv(strd,strc,stra,'V');    char fileresp[FILENAMELENGTH];
       Tvar[1]=atoi(strc);    
     }    pp=vector(1,nlstate);
   }    prop=matrix(1,nlstate,iagemin,iagemax+3);
   /* for (i=1; i<=5; i++)    strcpy(fileresp,"p");
      printf("i=%d %d ",i,Tvar[i]);*/    strcat(fileresp,fileres);
   /* printf("tvar=%d %d cptcovage=%d %d",Tvar[1],Tvar[2],cptcovage,Tage[1]);*/    if((ficresp=fopen(fileresp,"w"))==NULL) {
  /*printf("cptcovprod=%d ", cptcovprod);*/      printf("Problem with prevalence resultfile: %s\n", fileresp);
   /*  scanf("%d ",i);*/      fprintf(ficlog,"Problem with prevalence resultfile: %s\n", fileresp);
     fclose(fic);      exit(0);
     }
     /*  if(mle==1){*/    freq= ma3x(-5,nlstate+ndeath,-5,nlstate+ndeath,iagemin,iagemax+3);
     if (weightopt != 1) { /* Maximisation without weights*/    j1=0;
       for(i=1;i<=n;i++) weight[i]=1.0;    
     }    j=cptcoveff;
     /*-calculation of age at interview from date of interview and age at death -*/    if (cptcovn<1) {j=1;ncodemax[1]=1;}
     agev=matrix(1,maxwav,1,imx);  
        first=1;
     for (i=1; i<=imx; i++)  {  
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);    for(k1=1; k1<=j;k1++){
       for(m=1; (m<= maxwav); m++){      for(i1=1; i1<=ncodemax[k1];i1++){
         if(s[m][i] >0){        j1++;
           if (s[m][i] == nlstate+1) {        /*printf("cptcoveff=%d Tvaraff=%d", cptcoveff,Tvaraff[1]);
             if(agedc[i]>0)          scanf("%d", i);*/
               if(moisdc[i]!=99 && andc[i]!=9999)        for (i=-5; i<=nlstate+ndeath; i++)  
               agev[m][i]=agedc[i];          for (jk=-5; jk<=nlstate+ndeath; jk++)  
             else{            for(m=iagemin; m <= iagemax+3; m++)
               printf("Warning negative age at death: %d line:%d\n",num[i],i);              freq[i][jk][m]=0;
               agev[m][i]=-1;  
             }      for (i=1; i<=nlstate; i++)  
           }        for(m=iagemin; m <= iagemax+3; m++)
           else if(s[m][i] !=9){ /* Should no more exist */          prop[i][m]=0;
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);        
             if(mint[m][i]==99 || anint[m][i]==9999)        dateintsum=0;
               agev[m][i]=1;        k2cpt=0;
             else if(agev[m][i] <agemin){        for (i=1; i<=imx; i++) {
               agemin=agev[m][i];          bool=1;
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/          if  (cptcovn>0) {
             }            for (z1=1; z1<=cptcoveff; z1++) 
             else if(agev[m][i] >agemax){              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
               agemax=agev[m][i];                bool=0;
              /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/          }
             }          if (bool==1){
             /*agev[m][i]=anint[m][i]-annais[i];*/            for(m=firstpass; m<=lastpass; m++){
             /*   agev[m][i] = age[i]+2*m;*/              k2=anint[m][i]+(mint[m][i]/12.);
           }              /*if ((k2>=dateprev1) && (k2<=dateprev2)) {*/
           else { /* =9 */                if(agev[m][i]==0) agev[m][i]=iagemax+1;
             agev[m][i]=1;                if(agev[m][i]==1) agev[m][i]=iagemax+2;
             s[m][i]=-1;                if (s[m][i]>0 && s[m][i]<=nlstate) prop[s[m][i]][(int)agev[m][i]] += weight[i];
           }                if (m<lastpass) {
         }                  freq[s[m][i]][s[m+1][i]][(int)agev[m][i]] += weight[i];
         else /*= 0 Unknown */                  freq[s[m][i]][s[m+1][i]][iagemax+3] += weight[i];
           agev[m][i]=1;                }
       }                
                    if ((agev[m][i]>1) && (agev[m][i]< (iagemax+3))) {
     }                  dateintsum=dateintsum+k2;
     for (i=1; i<=imx; i++)  {                  k2cpt++;
       for(m=1; (m<= maxwav); m++){                }
         if (s[m][i] > (nlstate+ndeath)) {                /*}*/
           printf("Error: Wrong value in nlstate or ndeath\n");              }
           goto end;          }
         }        }
       }         
     }        /*      fprintf(ficresp, "#Count between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
         pstamp(ficresp);
 printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);        if  (cptcovn>0) {
           fprintf(ficresp, "\n#********** Variable "); 
     free_vector(severity,1,maxwav);          for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresp, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
     free_imatrix(outcome,1,maxwav+1,1,n);          fprintf(ficresp, "**********\n#");
     free_vector(moisnais,1,n);        }
     free_vector(annais,1,n);        for(i=1; i<=nlstate;i++) 
     free_matrix(mint,1,maxwav,1,n);          fprintf(ficresp, " Age Prev(%d) N(%d) N",i,i);
     free_matrix(anint,1,maxwav,1,n);        fprintf(ficresp, "\n");
     free_vector(moisdc,1,n);        
     free_vector(andc,1,n);        for(i=iagemin; i <= iagemax+3; i++){
           if(i==iagemax+3){
                fprintf(ficlog,"Total");
     wav=ivector(1,imx);          }else{
     dh=imatrix(1,lastpass-firstpass+1,1,imx);            if(first==1){
     mw=imatrix(1,lastpass-firstpass+1,1,imx);              first=0;
                  printf("See log file for details...\n");
     /* Concatenates waves */            }
       concatwav(wav, dh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);            fprintf(ficlog,"Age %d", i);
           }
           for(jk=1; jk <=nlstate ; jk++){
       Tcode=ivector(1,100);            for(m=-1, pp[jk]=0; m <=nlstate+ndeath ; m++)
       nbcode=imatrix(1,nvar,1,8);              pp[jk] += freq[jk][m][i]; 
       ncodemax[1]=1;          }
       if (cptcovn > 0) tricode(Tvar,nbcode,imx);          for(jk=1; jk <=nlstate ; jk++){
                  for(m=-1, pos=0; m <=0 ; m++)
    codtab=imatrix(1,100,1,10);              pos += freq[jk][m][i];
    h=0;            if(pp[jk]>=1.e-10){
    m=pow(2,cptcoveff);              if(first==1){
                printf(" %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
    for(k=1;k<=cptcoveff; k++){              }
      for(i=1; i <=(m/pow(2,k));i++){              fprintf(ficlog," %d.=%.0f loss[%d]=%.1f%%",jk,pp[jk],jk,100*pos/pp[jk]);
        for(j=1; j <= ncodemax[k]; j++){            }else{
          for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){              if(first==1)
            h++;                printf(" %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
            if (h>m) h=1;codtab[h][k]=j;              fprintf(ficlog," %d.=%.0f loss[%d]=NaNQ%%",jk,pp[jk],jk);
          }            }
        }          }
      }  
    }          for(jk=1; jk <=nlstate ; jk++){
             for(m=0, pp[jk]=0; m <=nlstate+ndeath; m++)
               pp[jk] += freq[jk][m][i];
    /*for(i=1; i <=m ;i++){          }       
      for(k=1; k <=cptcovn; k++){          for(jk=1,pos=0,posprop=0; jk <=nlstate ; jk++){
        printf("i=%d k=%d %d %d",i,k,codtab[i][k], cptcoveff);            pos += pp[jk];
      }            posprop += prop[jk][i];
      printf("\n");          }
    }          for(jk=1; jk <=nlstate ; jk++){
    scanf("%d",i);*/            if(pos>=1.e-5){
                  if(first==1)
    /* Calculates basic frequencies. Computes observed prevalence at single age                printf(" %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
        and prints on file fileres'p'. */              fprintf(ficlog," %d.=%.0f prev[%d]=%.1f%%",jk,pp[jk],jk,100*pp[jk]/pos);
   freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvar,nbcode, ncodemax);            }else{
               if(first==1)
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */                printf(" %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */              fprintf(ficlog," %d.=%.0f prev[%d]=NaNQ%%",jk,pp[jk],jk);
     newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */            }
     savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */            if( i <= iagemax){
     oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */              if(pos>=1.e-5){
                    fprintf(ficresp," %d %.5f %.0f %.0f",i,prop[jk][i]/posprop, prop[jk][i],posprop);
     /* For Powell, parameters are in a vector p[] starting at p[1]                /*probs[i][jk][j1]= pp[jk]/pos;*/
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */                /*printf("\ni=%d jk=%d j1=%d %.5f %.0f %.0f %f",i,jk,j1,pp[jk]/pos, pp[jk],pos,probs[i][jk][j1]);*/
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */              }
               else
     if(mle==1){                fprintf(ficresp," %d NaNq %.0f %.0f",i,prop[jk][i],posprop);
     mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);            }
     }          }
              
     /*--------- results files --------------*/          for(jk=-1; jk <=nlstate+ndeath; jk++)
     fprintf(ficres,"\ntitle=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncov=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncov, nlstate, ndeath, maxwav, mle,weightopt,model);            for(m=-1; m <=nlstate+ndeath; m++)
                  if(freq[jk][m][i] !=0 ) {
    jk=1;              if(first==1)
    fprintf(ficres,"# Parameters\n");                printf(" %d%d=%.0f",jk,m,freq[jk][m][i]);
    printf("# Parameters\n");                fprintf(ficlog," %d%d=%.0f",jk,m,freq[jk][m][i]);
    for(i=1,jk=1; i <=nlstate; i++){              }
      for(k=1; k <=(nlstate+ndeath); k++){          if(i <= iagemax)
        if (k != i)            fprintf(ficresp,"\n");
          {          if(first==1)
            printf("%d%d ",i,k);            printf("Others in log...\n");
            fprintf(ficres,"%1d%1d ",i,k);          fprintf(ficlog,"\n");
            for(j=1; j <=ncovmodel; j++){        }
              printf("%f ",p[jk]);      }
              fprintf(ficres,"%f ",p[jk]);    }
              jk++;    dateintmean=dateintsum/k2cpt; 
            }   
            printf("\n");    fclose(ficresp);
            fprintf(ficres,"\n");    free_ma3x(freq,-5,nlstate+ndeath,-5,nlstate+ndeath, iagemin, iagemax+3);
          }    free_vector(pp,1,nlstate);
      }    free_matrix(prop,1,nlstate,iagemin, iagemax+3);
    }    /* End of Freq */
  if(mle==1){  }
     /* Computing hessian and covariance matrix */  
     ftolhess=ftol; /* Usually correct */  /************ Prevalence ********************/
     hesscov(matcov, p, npar, delti, ftolhess, func);  void prevalence(double ***probs, double agemin, double agemax, int **s, double **agev, int nlstate, int imx, int *Tvar, int **nbcode, int *ncodemax,double **mint,double **anint, double dateprev1,double dateprev2, int firstpass, int lastpass)
  }  {  
     fprintf(ficres,"# Scales\n");    /* Compute observed prevalence between dateprev1 and dateprev2 by counting the number of people
     printf("# Scales\n");       in each health status at the date of interview (if between dateprev1 and dateprev2).
      for(i=1,jk=1; i <=nlstate; i++){       We still use firstpass and lastpass as another selection.
       for(j=1; j <=nlstate+ndeath; j++){    */
         if (j!=i) {   
           fprintf(ficres,"%1d%1d",i,j);    int i, m, jk, k1, i1, j1, bool, z1,z2,j;
           printf("%1d%1d",i,j);    double ***freq; /* Frequencies */
           for(k=1; k<=ncovmodel;k++){    double *pp, **prop;
             printf(" %.5e",delti[jk]);    double pos,posprop; 
             fprintf(ficres," %.5e",delti[jk]);    double  y2; /* in fractional years */
             jk++;    int iagemin, iagemax;
           }  
           printf("\n");    iagemin= (int) agemin;
           fprintf(ficres,"\n");    iagemax= (int) agemax;
         }    /*pp=vector(1,nlstate);*/
       }    prop=matrix(1,nlstate,iagemin,iagemax+3); 
       }    /*  freq=ma3x(-1,nlstate+ndeath,-1,nlstate+ndeath,iagemin,iagemax+3);*/
        j1=0;
     k=1;    
     fprintf(ficres,"# Covariance\n");    j=cptcoveff;
     printf("# Covariance\n");    if (cptcovn<1) {j=1;ncodemax[1]=1;}
     for(i=1;i<=npar;i++){    
       /*  if (k>nlstate) k=1;    for(k1=1; k1<=j;k1++){
       i1=(i-1)/(ncovmodel*nlstate)+1;      for(i1=1; i1<=ncodemax[k1];i1++){
       fprintf(ficres,"%s%d%d",alph[k],i1,tab[i]);        j1++;
       printf("%s%d%d",alph[k],i1,tab[i]);*/        
       fprintf(ficres,"%3d",i);        for (i=1; i<=nlstate; i++)  
       printf("%3d",i);          for(m=iagemin; m <= iagemax+3; m++)
       for(j=1; j<=i;j++){            prop[i][m]=0.0;
         fprintf(ficres," %.5e",matcov[i][j]);       
         printf(" %.5e",matcov[i][j]);        for (i=1; i<=imx; i++) { /* Each individual */
       }          bool=1;
       fprintf(ficres,"\n");          if  (cptcovn>0) {
       printf("\n");            for (z1=1; z1<=cptcoveff; z1++) 
       k++;              if (covar[Tvaraff[z1]][i]!= nbcode[Tvaraff[z1]][codtab[j1][z1]]) 
     }                bool=0;
              } 
     while((c=getc(ficpar))=='#' && c!= EOF){          if (bool==1) { 
       ungetc(c,ficpar);            for(m=firstpass; m<=lastpass; m++){/* Other selection (we can limit to certain interviews*/
       fgets(line, MAXLINE, ficpar);              y2=anint[m][i]+(mint[m][i]/12.); /* Fractional date in year */
       puts(line);              if ((y2>=dateprev1) && (y2<=dateprev2)) { /* Here is the main selection (fractional years) */
       fputs(line,ficparo);                if(agev[m][i]==0) agev[m][i]=iagemax+1;
     }                if(agev[m][i]==1) agev[m][i]=iagemax+2;
     ungetc(c,ficpar);                if((int)agev[m][i] <iagemin || (int)agev[m][i] >iagemax+3) printf("Error on individual =%d agev[m][i]=%f m=%d\n",i, agev[m][i],m); 
                  if (s[m][i]>0 && s[m][i]<=nlstate) { 
     fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);                  /*if(i>4620) printf(" i=%d m=%d s[m][i]=%d (int)agev[m][i]=%d weight[i]=%f prop=%f\n",i,m,s[m][i],(int)agev[m][m],weight[i],prop[s[m][i]][(int)agev[m][i]]);*/
                      prop[s[m][i]][(int)agev[m][i]] += weight[i];
     if (fage <= 2) {                  prop[s[m][i]][iagemax+3] += weight[i]; 
       bage = agemin;                } 
       fage = agemax;              }
     }            } /* end selection of waves */
           }
     fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");        }
     fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);        for(i=iagemin; i <= iagemax+3; i++){  
           
              for(jk=1,posprop=0; jk <=nlstate ; jk++) { 
 /*------------ gnuplot -------------*/            posprop += prop[jk][i]; 
 chdir(pathcd);          } 
   if((ficgp=fopen("graph.plt","w"))==NULL) {  
     printf("Problem with file graph.gp");goto end;          for(jk=1; jk <=nlstate ; jk++){     
   }            if( i <=  iagemax){ 
 #ifdef windows              if(posprop>=1.e-5){ 
   fprintf(ficgp,"cd \"%s\" \n",pathc);                probs[i][jk][j1]= prop[jk][i]/posprop;
 #endif              } 
 m=pow(2,cptcoveff);            } 
            }/* end jk */ 
  /* 1eme*/        }/* end i */ 
   for (cpt=1; cpt<= nlstate ; cpt ++) {      } /* end i1 */
    for (k1=1; k1<= m ; k1 ++) {    } /* end k1 */
     
 #ifdef windows    /*  free_ma3x(freq,-1,nlstate+ndeath,-1,nlstate+ndeath, iagemin, iagemax+3);*/
     fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"vpl%s\" every :::%d::%d u 1:2 \"\%%lf",agemin,fage,fileres,k1-1,k1-1);    /*free_vector(pp,1,nlstate);*/
 #endif    free_matrix(prop,1,nlstate, iagemin,iagemax+3);
 #ifdef unix  }  /* End of prevalence */
 fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nplot [%.f:%.f] \"vpl%s\" u 1:2 \"\%%lf",agemin,fage,fileres);  
 #endif  /************* Waves Concatenation ***************/
   
 for (i=1; i<= nlstate ; i ++) {  void  concatwav(int wav[], int **dh, int **bh,  int **mw, int **s, double *agedc, double **agev, int  firstpass, int lastpass, int imx, int nlstate, int stepm)
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");  {
   else fprintf(ficgp," \%%*lf (\%%*lf)");    /* Concatenates waves: wav[i] is the number of effective (useful waves) of individual i.
 }       Death is a valid wave (if date is known).
     fprintf(ficgp,"\" t\"Stationary prevalence\" w l 0,\"vpl%s\" every :::%d::%d u 1:($2+2*$3) \"\%%lf",fileres,k1-1,k1-1);       mw[mi][i] is the mi (mi=1 to wav[i])  effective wave of individual i
     for (i=1; i<= nlstate ; i ++) {       dh[m][i] or dh[mw[mi][i]][i] is the delay between two effective waves m=mw[mi][i]
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");       and mw[mi+1][i]. dh depends on stepm.
   else fprintf(ficgp," \%%*lf (\%%*lf)");       */
 }  
   fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"vpl%s\" every :::%d::%d u 1:($2-2*$3) \"\%%lf",fileres,k1-1,k1-1);    int i, mi, m;
      for (i=1; i<= nlstate ; i ++) {    /* int j, k=0,jk, ju, jl,jmin=1e+5, jmax=-1;
   if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");       double sum=0., jmean=0.;*/
   else fprintf(ficgp," \%%*lf (\%%*lf)");    int first;
 }      int j, k=0,jk, ju, jl;
      fprintf(ficgp,"\" t\"\" w l 1,\"p%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",fileres,k1-1,k1-1,2+4*(cpt-1));    double sum=0.;
 #ifdef unix    first=0;
 fprintf(ficgp,"\nset ter gif small size 400,300");    jmin=1e+5;
 #endif    jmax=-1;
 fprintf(ficgp,"\nset out \"v%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);    jmean=0.;
    }    for(i=1; i<=imx; i++){
   }      mi=0;
   /*2 eme*/      m=firstpass;
       while(s[m][i] <= nlstate){
   for (k1=1; k1<= m ; k1 ++) {        if(s[m][i]>=1 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5)
     fprintf(ficgp,"set ylabel \"Years\" \nset ter gif small size 400,300\nplot [%.f:%.f] ",agemin,fage);          mw[++mi][i]=m;
            if(m >=lastpass)
     for (i=1; i<= nlstate+1 ; i ++) {          break;
       k=2*i;        else
       fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:2 \"\%%lf",fileres,k1-1,k1-1);          m++;
       for (j=1; j<= nlstate+1 ; j ++) {      }/* end while */
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");      if (s[m][i] > nlstate){
   else fprintf(ficgp," \%%*lf (\%%*lf)");        mi++;     /* Death is another wave */
 }          /* if(mi==0)  never been interviewed correctly before death */
       if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");           /* Only death is a correct wave */
       else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);        mw[mi][i]=m;
     fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",fileres,k1-1,k1-1);      }
       for (j=1; j<= nlstate+1 ; j ++) {  
         if (j==i) fprintf(ficgp," \%%lf (\%%lf)");      wav[i]=mi;
         else fprintf(ficgp," \%%*lf (\%%*lf)");      if(mi==0){
 }          nbwarn++;
       fprintf(ficgp,"\" t\"\" w l 0,");        if(first==0){
      fprintf(ficgp,"\"t%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",fileres,k1-1,k1-1);          printf("Warning! No valid information for individual %ld line=%d (skipped) and may be others, see log file\n",num[i],i);
       for (j=1; j<= nlstate+1 ; j ++) {          first=1;
   if (j==i) fprintf(ficgp," \%%lf (\%%lf)");        }
   else fprintf(ficgp," \%%*lf (\%%*lf)");        if(first==1){
 }            fprintf(ficlog,"Warning! No valid information for individual %ld line=%d (skipped)\n",num[i],i);
       if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");        }
       else fprintf(ficgp,"\" t\"\" w l 0,");      } /* end mi==0 */
     }    } /* End individuals */
     fprintf(ficgp,"\nset out \"e%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),k1);  
   }    for(i=1; i<=imx; i++){
        for(mi=1; mi<wav[i];mi++){
   /*3eme*/        if (stepm <=0)
           dh[mi][i]=1;
   for (k1=1; k1<= m ; k1 ++) {        else{
     for (cpt=1; cpt<= nlstate ; cpt ++) {          if (s[mw[mi+1][i]][i] > nlstate) { /* A death */
       k=2+nlstate*(cpt-1);            if (agedc[i] < 2*AGESUP) {
       fprintf(ficgp,"set ter gif small size 400,300\nplot [%.f:%.f] \"e%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",agemin,fage,fileres,k1-1,k1-1,k,cpt);              j= rint(agedc[i]*12-agev[mw[mi][i]][i]*12); 
       for (i=1; i< nlstate ; i ++) {              if(j==0) j=1;  /* Survives at least one month after exam */
         fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",fileres,k1-1,k1-1,k+i,cpt,i+1);              else if(j<0){
       }                nberr++;
       fprintf(ficgp,"\nset out \"exp%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);                printf("Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
     }                j=1; /* Temporary Dangerous patch */
   }                printf("   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
                  fprintf(ficlog,"Error! Negative delay (%d to death) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   /* CV preval stat */                fprintf(ficlog,"   We assumed that the date of interview was correct (and not the date of death) and postponed the death %d month(s) (one stepm) after the interview. You MUST fix the contradiction between dates.\n",stepm);
   for (k1=1; k1<= m ; k1 ++) {              }
     for (cpt=1; cpt<nlstate ; cpt ++) {              k=k+1;
       k=3;              if (j >= jmax){
       fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \nset ter gif small size 400,300\nplot [%.f:%.f] \"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",agemin,agemax,fileres,k1,k+cpt+1,k+1);                jmax=j;
       for (i=1; i< nlstate ; i ++)                ijmax=i;
         fprintf(ficgp,"+$%d",k+i+1);              }
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);              if (j <= jmin){
                      jmin=j;
       l=3+(nlstate+ndeath)*cpt;                ijmin=i;
       fprintf(ficgp,",\"pij%s\" u ($1==%d ? ($3):1/0):($%d/($%d",fileres,k1,l+cpt+1,l+1);              }
       for (i=1; i< nlstate ; i ++) {              sum=sum+j;
         l=3+(nlstate+ndeath)*cpt;              /*if (j<0) printf("j=%d num=%d \n",j,i);*/
         fprintf(ficgp,"+$%d",l+i+1);              /*    printf("%d %d %d %d\n", s[mw[mi][i]][i] ,s[mw[mi+1][i]][i],j,i);*/
       }            }
       fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);            }
       fprintf(ficgp,"set out \"p%s%d%d.gif\" \nreplot\n\n",strtok(optionfile, "."),cpt,k1);          else{
     }            j= rint( (agev[mw[mi+1][i]][i]*12 - agev[mw[mi][i]][i]*12));
   }  /*        if (j<0) printf("%d %lf %lf %d %d %d\n", i,agev[mw[mi+1][i]][i], agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]); */
   
   /* proba elementaires */            k=k+1;
    for(i=1,jk=1; i <=nlstate; i++){            if (j >= jmax) {
     for(k=1; k <=(nlstate+ndeath); k++){              jmax=j;
       if (k != i) {              ijmax=i;
         for(j=1; j <=ncovmodel; j++){            }
           /*fprintf(ficgp,"%s%1d%1d=%f ",alph[j],i,k,p[jk]);*/            else if (j <= jmin){
           /*fprintf(ficgp,"%s",alph[1]);*/              jmin=j;
           fprintf(ficgp,"p%d=%f ",jk,p[jk]);              ijmin=i;
           jk++;            }
           fprintf(ficgp,"\n");            /*        if (j<10) printf("j=%d jmin=%d num=%d ",j,jmin,i); */
         }            /*printf("%d %lf %d %d %d\n", i,agev[mw[mi][i]][i],j,s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);*/
       }            if(j<0){
     }              nberr++;
     }              printf("Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
               fprintf(ficlog,"Error! Negative delay (%d) between waves %d and %d of individual %ld at line %d who is aged %.1f with statuses from %d to %d\n ",j,mw[mi][i],mw[mi+1][i],num[i], i,agev[mw[mi][i]][i],s[mw[mi][i]][i] ,s[mw[mi+1][i]][i]);
   for(jk=1; jk <=m; jk++) {            }
   fprintf(ficgp,"\nset ter gif small size 400,300\nset log y\nplot  [%.f:%.f] ",agemin,agemax);            sum=sum+j;
    i=1;          }
    for(k2=1; k2<=nlstate; k2++) {          jk= j/stepm;
      k3=i;          jl= j -jk*stepm;
      for(k=1; k<=(nlstate+ndeath); k++) {          ju= j -(jk+1)*stepm;
        if (k != k2){          if(mle <=1){ /* only if we use a the linear-interpoloation pseudo-likelihood */
         fprintf(ficgp," exp(p%d+p%d*x",i,i+1);            if(jl==0){
 ij=1;              dh[mi][i]=jk;
         for(j=3; j <=ncovmodel; j++) {              bh[mi][i]=0;
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {            }else{ /* We want a negative bias in order to only have interpolation ie
             fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);                    * at the price of an extra matrix product in likelihood */
             ij++;              dh[mi][i]=jk+1;
           }              bh[mi][i]=ju;
           else            }
           fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);          }else{
         }            if(jl <= -ju){
           fprintf(ficgp,")/(1");              dh[mi][i]=jk;
                      bh[mi][i]=jl;       /* bias is positive if real duration
         for(k1=1; k1 <=nlstate; k1++){                                     * is higher than the multiple of stepm and negative otherwise.
           fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);                                   */
 ij=1;            }
           for(j=3; j <=ncovmodel; j++){            else{
           if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {              dh[mi][i]=jk+1;
             fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);              bh[mi][i]=ju;
             ij++;            }
           }            if(dh[mi][i]==0){
           else              dh[mi][i]=1; /* At least one step */
             fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);              bh[mi][i]=ju; /* At least one step */
           }              /*  printf(" bh=%d ju=%d jl=%d dh=%d jk=%d stepm=%d %d\n",bh[mi][i],ju,jl,dh[mi][i],jk,stepm,i);*/
           fprintf(ficgp,")");            }
         }          } /* end if mle */
         fprintf(ficgp,") t \"p%d%d\" ", k2,k);        }
         if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");      } /* end wave */
         i=i+ncovmodel;    }
        }    jmean=sum/k;
      }    printf("Delay (in months) between two waves Min=%d (for indiviudal %ld) Max=%d (%ld) Mean=%f\n\n ",jmin, num[ijmin], jmax, num[ijmax], jmean);
    }    fprintf(ficlog,"Delay (in months) between two waves Min=%d (for indiviudal %ld) Max=%d (%ld) Mean=%f\n\n ",jmin, ijmin, jmax, ijmax, jmean);
    fprintf(ficgp,"\nset out \"pe%s%d.gif\" \nreplot\n\n",strtok(optionfile, "."),jk);   }
   }  
      /*********** Tricode ****************************/
   fclose(ficgp);  void tricode(int *Tvar, int **nbcode, int imx)
      {
 chdir(path);    
     free_matrix(agev,1,maxwav,1,imx);    int Ndum[20],ij=1, k, j, i, maxncov=19;
     free_ivector(wav,1,imx);    int cptcode=0;
     free_imatrix(dh,1,lastpass-firstpass+1,1,imx);    cptcoveff=0; 
     free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
        for (k=0; k<maxncov; k++) Ndum[k]=0;
     free_imatrix(s,1,maxwav+1,1,n);    for (k=1; k<=7; k++) ncodemax[k]=0;
      
        for (j=1; j<=(cptcovn+2*cptcovprod); j++) {
     free_ivector(num,1,n);      for (i=1; i<=imx; i++) { /*reads the data file to get the maximum 
     free_vector(agedc,1,n);                                 modality*/ 
     free_vector(weight,1,n);        ij=(int)(covar[Tvar[j]][i]); /* ij is the modality of this individual*/
     /*free_matrix(covar,1,NCOVMAX,1,n);*/        Ndum[ij]++; /*store the modality */
     fclose(ficparo);        /*printf("i=%d ij=%d Ndum[ij]=%d imx=%d",i,ij,Ndum[ij],imx);*/
     fclose(ficres);        if (ij > cptcode) cptcode=ij; /* getting the maximum of covariable 
     /*  }*/                                         Tvar[j]. If V=sex and male is 0 and 
                                             female is 1, then  cptcode=1.*/
    /*________fin mle=1_________*/      }
      
       for (i=0; i<=cptcode; i++) {
          if(Ndum[i]!=0) ncodemax[j]++; /* Nomber of modalities of the j th covariates. In fact ncodemax[j]=2 (dichotom. variables) but it can be more */
     /* No more information from the sample is required now */      }
   /* Reads comments: lines beginning with '#' */  
   while((c=getc(ficpar))=='#' && c!= EOF){      ij=1; 
     ungetc(c,ficpar);      for (i=1; i<=ncodemax[j]; i++) {
     fgets(line, MAXLINE, ficpar);        for (k=0; k<= maxncov; k++) {
     puts(line);          if (Ndum[k] != 0) {
     fputs(line,ficparo);            nbcode[Tvar[j]][ij]=k; 
   }            /* store the modality in an array. k is a modality. If we have model=V1+V1*sex then: nbcode[1][1]=0 ; nbcode[1][2]=1; nbcode[2][1]=0 ; nbcode[2][2]=1; */
   ungetc(c,ficpar);            
              ij++;
   fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf\n",&agemin,&agemax, &bage, &fage);          }
   printf("agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax, bage, fage);          if (ij > ncodemax[j]) break; 
   fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f\n",agemin,agemax,bage,fage);        }  
 /*--------- index.htm --------*/      } 
     }  
   if((fichtm=fopen("index.htm","w"))==NULL)    {  
     printf("Problem with index.htm \n");goto end;   for (k=0; k< maxncov; k++) Ndum[k]=0;
   }  
    for (i=1; i<=ncovmodel-2; i++) { 
  fprintf(fichtm,"<body><ul> Imach, Version 0.64a<hr> <li>Outputs files<br><br>\n     /* Listing of all covariables in statement model to see if some covariates appear twice. For example, V1 appears twice in V1+V1*V2.*/
         - Observed prevalence in each state: <a href=\"p%s\">p%s</a> <br>\n     ij=Tvar[i];
 - Estimated parameters and the covariance matrix: <a href=\"%s\">%s</a> <br>     Ndum[ij]++;
         - Stationary prevalence in each state: <a href=\"pl%s\">pl%s</a> <br>   }
         - Transition probabilities: <a href=\"pij%s\">pij%s</a><br>  
         - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>   ij=1;
         - Life expectancies by age and initial health status: <a href=\"e%s\">e%s</a> <br>   for (i=1; i<= maxncov; i++) {
         - Variances of life expectancies by age and initial health status: <a href=\"v%s\">v%s</a><br>     if((Ndum[i]!=0) && (i<=ncovcol)){
         - Health expectancies with their variances: <a href=\"t%s\">t%s</a> <br>       Tvaraff[ij]=i; /*For printing */
         - Standard deviation of stationary prevalences: <a href=\"vpl%s\">vpl%s</a> <br><br>",fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres,fileres);       ij++;
      }
  fprintf(fichtm," <li>Graphs</li>\n<p>");   }
    
  m=cptcoveff;   cptcoveff=ij-1; /*Number of simple covariates*/
  if (cptcovn < 1) {m=1;ncodemax[1]=1;}  }
   
  j1=0;  /*********** Health Expectancies ****************/
  for(k1=1; k1<=m;k1++){  
    for(i1=1; i1<=ncodemax[k1];i1++){  void evsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int cij, int estepm,char strstart[] )
        j1++;  
        if (cptcovn > 0) {  {
          fprintf(fichtm,"<hr>************ Results for covariates");    /* Health expectancies, no variances */
          for (cpt=1; cpt<=cptcoveff;cpt++)    int i, j, nhstepm, hstepm, h, nstepm, k, cptj, cptj2, i2, j2;
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[j1][cpt]]);    double age, agelim, hf;
          fprintf(fichtm," ************\n<hr>");    double ***p3mat;
        }    double eip;
        fprintf(fichtm,"<br>- Probabilities: pe%s%d.gif<br>  
 <img src=\"pe%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);        pstamp(ficreseij);
        for(cpt=1; cpt<nlstate;cpt++){    fprintf(ficreseij,"# (a) Life expectancies by health status at initial age and (b) health expectancies by health status at initial age\n");
          fprintf(fichtm,"<br>- Prevalence of disability : p%s%d%d.gif<br>    fprintf(ficreseij,"# Age");
 <img src=\"p%s%d%d.gif\">",strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);    for(i=1; i<=nlstate;i++){
        }      for(j=1; j<=nlstate;j++){
     for(cpt=1; cpt<=nlstate;cpt++) {        fprintf(ficreseij," e%1d%1d ",i,j);
        fprintf(fichtm,"<br>- Observed and stationary prevalence (with confident      }
 interval) in state (%d): v%s%d%d.gif <br>      fprintf(ficreseij," e%1d. ",i);
 <img src=\"v%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);      }
      }    fprintf(ficreseij,"\n");
      for(cpt=1; cpt<=nlstate;cpt++) {  
         fprintf(fichtm,"\n<br>- Health life expectancies by age and initial health state (%d): exp%s%d%d.gif <br>    
 <img src=\"exp%s%d%d.gif\">",cpt,strtok(optionfile, "."),cpt,j1,strtok(optionfile, "."),cpt,j1);    if(estepm < stepm){
      }      printf ("Problem %d lower than %d\n",estepm, stepm);
      fprintf(fichtm,"\n<br>- Total life expectancy by age and    }
 health expectancies in states (1) and (2): e%s%d.gif<br>    else  hstepm=estepm;   
 <img src=\"e%s%d.gif\">",strtok(optionfile, "."),j1,strtok(optionfile, "."),j1);    /* We compute the life expectancy from trapezoids spaced every estepm months
 fprintf(fichtm,"\n</body>");     * This is mainly to measure the difference between two models: for example
    }     * if stepm=24 months pijx are given only every 2 years and by summing them
  }     * we are calculating an estimate of the Life Expectancy assuming a linear 
 fclose(fichtm);     * progression in between and thus overestimating or underestimating according
      * to the curvature of the survival function. If, for the same date, we 
   /*--------------- Prevalence limit --------------*/     * estimate the model with stepm=1 month, we can keep estepm to 24 months
       * to compare the new estimate of Life expectancy with the same linear 
   strcpy(filerespl,"pl");     * hypothesis. A more precise result, taking into account a more precise
   strcat(filerespl,fileres);     * curvature will be obtained if estepm is as small as stepm. */
   if((ficrespl=fopen(filerespl,"w"))==NULL) {  
     printf("Problem with Prev limit resultfile: %s\n", filerespl);goto end;    /* For example we decided to compute the life expectancy with the smallest unit */
   }    /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
   printf("Computing prevalence limit: result on file '%s' \n", filerespl);       nhstepm is the number of hstepm from age to agelim 
   fprintf(ficrespl,"#Prevalence limit\n");       nstepm is the number of stepm from age to agelin. 
   fprintf(ficrespl,"#Age ");       Look at hpijx to understand the reason of that which relies in memory size
   for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);       and note for a fixed period like estepm months */
   fprintf(ficrespl,"\n");    /* We decided (b) to get a life expectancy respecting the most precise curvature of the
         survival function given by stepm (the optimization length). Unfortunately it
   prlim=matrix(1,nlstate,1,nlstate);       means that if the survival funtion is printed only each two years of age and if
   pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */       you sum them up and add 1 year (area under the trapezoids) you won't get the same 
   oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */       results. So we changed our mind and took the option of the best precision.
   newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    */
   savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
   oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */  
   k=0;    agelim=AGESUP;
   agebase=agemin;    /* nhstepm age range expressed in number of stepm */
   agelim=agemax;    nstepm=(int) rint((agelim-age)*YEARM/stepm); 
   ftolpl=1.e-10;    /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
   i1=cptcoveff;    /* if (stepm >= YEARM) hstepm=1;*/
   if (cptcovn < 1){i1=1;}    nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
     p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
   for(cptcov=1;cptcov<=i1;cptcov++){  
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){    for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
         k=k+1;      /* Computed by stepm unit matrices, product of hstepm matrices, stored
         /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
         fprintf(ficrespl,"\n#******");  
         for(j=1;j<=cptcoveff;j++)      hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, cij);  
           fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);   
         fprintf(ficrespl,"******\n");      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
          
         for (age=agebase; age<=agelim; age++){      /* Computing  Variances of health expectancies */
           prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);      /* Gradient is computed with plus gp and minus gm. Code is duplicated in order to
           fprintf(ficrespl,"%.0f",age );         decrease memory allocation */
           for(i=1; i<=nlstate;i++)       printf("%d|",(int)age);fflush(stdout);
           fprintf(ficrespl," %.5f", prlim[i][i]);       fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
           fprintf(ficrespl,"\n");      /* Computing expectancies */
         }      for(i=1; i<=nlstate;i++)
       }        for(j=1; j<=nlstate;j++)
     }          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
   fclose(ficrespl);            eij[i][j][(int)age] += (p3mat[i][j][h]+p3mat[i][j][h+1])/2.0*hf;
   /*------------- h Pij x at various ages ------------*/            
    /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
   strcpy(filerespij,"pij");  strcat(filerespij,fileres);  
   if((ficrespij=fopen(filerespij,"w"))==NULL) {          }
     printf("Problem with Pij resultfile: %s\n", filerespij);goto end;  
   }      fprintf(ficreseij,"%3.0f",age );
   printf("Computing pij: result on file '%s' \n", filerespij);      for(i=1; i<=nlstate;i++){
          eip=0;
   stepsize=(int) (stepm+YEARM-1)/YEARM;        for(j=1; j<=nlstate;j++){
   if (stepm<=24) stepsize=2;          eip +=eij[i][j][(int)age];
           fprintf(ficreseij,"%9.4f", eij[i][j][(int)age] );
   agelim=AGESUP;        }
   hstepm=stepsize*YEARM; /* Every year of age */        fprintf(ficreseij,"%9.4f", eip );
   hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */      }
        fprintf(ficreseij,"\n");
   k=0;  
   for(cptcov=1;cptcov<=i1;cptcov++){    }
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){    free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       k=k+1;    printf("\n");
         fprintf(ficrespij,"\n#****** ");    fprintf(ficlog,"\n");
         for(j=1;j<=cptcoveff;j++)  
           fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);  }
         fprintf(ficrespij,"******\n");  
          void cvevsij(char fileres[], double ***eij, double x[], int nlstate, int stepm, int bage, int fage, double **oldm, double **savm, int cij, int estepm,double delti[],double **matcov,char strstart[] )
         for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */  
           nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */  {
           nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */    /* Covariances of health expectancies eij and of total life expectancies according
           p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);     to initial status i, ei. .
           oldm=oldms;savm=savms;    */
           hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);      int i, j, nhstepm, hstepm, h, nstepm, k, cptj, cptj2, i2, j2, ij, ji;
           fprintf(ficrespij,"# Age");    double age, agelim, hf;
           for(i=1; i<=nlstate;i++)    double ***p3matp, ***p3matm, ***varhe;
             for(j=1; j<=nlstate+ndeath;j++)    double **dnewm,**doldm;
               fprintf(ficrespij," %1d-%1d",i,j);    double *xp, *xm;
           fprintf(ficrespij,"\n");    double **gp, **gm;
           for (h=0; h<=nhstepm; h++){    double ***gradg, ***trgradg;
             fprintf(ficrespij,"%d %.0f %.0f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );    int theta;
             for(i=1; i<=nlstate;i++)  
               for(j=1; j<=nlstate+ndeath;j++)    double eip, vip;
                 fprintf(ficrespij," %.5f", p3mat[i][j][h]);  
             fprintf(ficrespij,"\n");    varhe=ma3x(1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int) fage);
           }    xp=vector(1,npar);
           free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);    xm=vector(1,npar);
           fprintf(ficrespij,"\n");    dnewm=matrix(1,nlstate*nlstate,1,npar);
         }    doldm=matrix(1,nlstate*nlstate,1,nlstate*nlstate);
     }    
   }    pstamp(ficresstdeij);
     fprintf(ficresstdeij,"# Health expectancies with standard errors\n");
   fclose(ficrespij);    fprintf(ficresstdeij,"# Age");
     for(i=1; i<=nlstate;i++){
   /*---------- Health expectancies and variances ------------*/      for(j=1; j<=nlstate;j++)
         fprintf(ficresstdeij," e%1d%1d (SE)",i,j);
   strcpy(filerest,"t");      fprintf(ficresstdeij," e%1d. ",i);
   strcat(filerest,fileres);    }
   if((ficrest=fopen(filerest,"w"))==NULL) {    fprintf(ficresstdeij,"\n");
     printf("Problem with total LE resultfile: %s\n", filerest);goto end;  
   }    pstamp(ficrescveij);
   printf("Computing Total LEs with variances: file '%s' \n", filerest);    fprintf(ficrescveij,"# Subdiagonal matrix of covariances of health expectancies by age: cov(eij,ekl)\n");
     fprintf(ficrescveij,"# Age");
     for(i=1; i<=nlstate;i++)
   strcpy(filerese,"e");      for(j=1; j<=nlstate;j++){
   strcat(filerese,fileres);        cptj= (j-1)*nlstate+i;
   if((ficreseij=fopen(filerese,"w"))==NULL) {        for(i2=1; i2<=nlstate;i2++)
     printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);          for(j2=1; j2<=nlstate;j2++){
   }            cptj2= (j2-1)*nlstate+i2;
   printf("Computing Health Expectancies: result on file '%s' \n", filerese);            if(cptj2 <= cptj)
               fprintf(ficrescveij,"  %1d%1d,%1d%1d",i,j,i2,j2);
  strcpy(fileresv,"v");          }
   strcat(fileresv,fileres);      }
   if((ficresvij=fopen(fileresv,"w"))==NULL) {    fprintf(ficrescveij,"\n");
     printf("Problem with variance resultfile: %s\n", fileresv);exit(0);    
   }    if(estepm < stepm){
   printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);      printf ("Problem %d lower than %d\n",estepm, stepm);
     }
   k=0;    else  hstepm=estepm;   
   for(cptcov=1;cptcov<=i1;cptcov++){    /* We compute the life expectancy from trapezoids spaced every estepm months
     for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){     * This is mainly to measure the difference between two models: for example
       k=k+1;     * if stepm=24 months pijx are given only every 2 years and by summing them
       fprintf(ficrest,"\n#****** ");     * we are calculating an estimate of the Life Expectancy assuming a linear 
       for(j=1;j<=cptcoveff;j++)     * progression in between and thus overestimating or underestimating according
         fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);     * to the curvature of the survival function. If, for the same date, we 
       fprintf(ficrest,"******\n");     * estimate the model with stepm=1 month, we can keep estepm to 24 months
      * to compare the new estimate of Life expectancy with the same linear 
       fprintf(ficreseij,"\n#****** ");     * hypothesis. A more precise result, taking into account a more precise
       for(j=1;j<=cptcoveff;j++)     * curvature will be obtained if estepm is as small as stepm. */
         fprintf(ficreseij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);  
       fprintf(ficreseij,"******\n");    /* For example we decided to compute the life expectancy with the smallest unit */
     /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
       fprintf(ficresvij,"\n#****** ");       nhstepm is the number of hstepm from age to agelim 
       for(j=1;j<=cptcoveff;j++)       nstepm is the number of stepm from age to agelin. 
         fprintf(ficresvij,"V%d=%d ",j,nbcode[j][codtab[k][j]]);       Look at hpijx to understand the reason of that which relies in memory size
       fprintf(ficresvij,"******\n");       and note for a fixed period like estepm months */
     /* We decided (b) to get a life expectancy respecting the most precise curvature of the
       eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);       survival function given by stepm (the optimization length). Unfortunately it
       oldm=oldms;savm=savms;       means that if the survival funtion is printed only each two years of age and if
       evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k);         you sum them up and add 1 year (area under the trapezoids) you won't get the same 
       vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);       results. So we changed our mind and took the option of the best precision.
       oldm=oldms;savm=savms;    */
       varevsij(fileres, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);    hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
        
       fprintf(ficrest,"#Total LEs with variances: e.. (std) ");    /* If stepm=6 months */
       for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);    /* nhstepm age range expressed in number of stepm */
       fprintf(ficrest,"\n");    agelim=AGESUP;
            nstepm=(int) rint((agelim-age)*YEARM/stepm); 
       hf=1;    /* Typically if 20 years nstepm = 20*12/6=40 stepm */ 
       if (stepm >= YEARM) hf=stepm/YEARM;    /* if (stepm >= YEARM) hstepm=1;*/
       epj=vector(1,nlstate+1);    nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       for(age=bage; age <=fage ;age++){    
         prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);    p3matp=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
         fprintf(ficrest," %.0f",age);    p3matm=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
         for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){    gradg=ma3x(0,nhstepm,1,npar,1,nlstate*nlstate);
           for(i=1, epj[j]=0.;i <=nlstate;i++) {    trgradg =ma3x(0,nhstepm,1,nlstate*nlstate,1,npar);
             epj[j] += prlim[i][i]*hf*eij[i][j][(int)age];    gp=matrix(0,nhstepm,1,nlstate*nlstate);
           }    gm=matrix(0,nhstepm,1,nlstate*nlstate);
           epj[nlstate+1] +=epj[j];  
         }    for (age=bage; age<=fage; age ++){ 
         for(i=1, vepp=0.;i <=nlstate;i++)  
           for(j=1;j <=nlstate;j++)      /* Computed by stepm unit matrices, product of hstepm matrices, stored
             vepp += vareij[i][j][(int)age];         in an array of nhstepm length: nhstepm=10, hstepm=4, stepm=6 months */
         fprintf(ficrest," %.2f (%.2f)", epj[nlstate+1],hf*sqrt(vepp));   
         for(j=1;j <=nlstate;j++){      hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
           fprintf(ficrest," %.2f (%.2f)", epj[j],hf*sqrt(vareij[j][j][(int)age]));  
         }      /* Computing  Variances of health expectancies */
         fprintf(ficrest,"\n");      /* Gradient is computed with plus gp and minus gm. Code is duplicated in order to
       }         decrease memory allocation */
     }      for(theta=1; theta <=npar; theta++){
   }        for(i=1; i<=npar; i++){ 
                  xp[i] = x[i] + (i==theta ?delti[theta]:0);
  fclose(ficreseij);          xm[i] = x[i] - (i==theta ?delti[theta]:0);
  fclose(ficresvij);        }
   fclose(ficrest);        hpxij(p3matp,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, cij);  
   fclose(ficpar);        hpxij(p3matm,nhstepm,age,hstepm,xm,nlstate,stepm,oldm,savm, cij);  
   free_vector(epj,1,nlstate+1);    
   /*  scanf("%d ",i); */        for(j=1; j<= nlstate; j++){
           for(i=1; i<=nlstate; i++){
   /*------- Variance limit prevalence------*/              for(h=0; h<=nhstepm-1; h++){
               gp[h][(j-1)*nlstate + i] = (p3matp[i][j][h]+p3matp[i][j][h+1])/2.;
 strcpy(fileresvpl,"vpl");              gm[h][(j-1)*nlstate + i] = (p3matm[i][j][h]+p3matm[i][j][h+1])/2.;
   strcat(fileresvpl,fileres);            }
   if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {          }
     printf("Problem with variance prev lim resultfile: %s\n", fileresvpl);        }
     exit(0);       
   }        for(ij=1; ij<= nlstate*nlstate; ij++)
   printf("Computing Variance-covariance of Prevalence limit: file '%s' \n", fileresvpl);          for(h=0; h<=nhstepm-1; h++){
             gradg[h][theta][ij]= (gp[h][ij]-gm[h][ij])/2./delti[theta];
  k=0;          }
  for(cptcov=1;cptcov<=i1;cptcov++){      }/* End theta */
    for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){      
      k=k+1;      
      fprintf(ficresvpl,"\n#****** ");      for(h=0; h<=nhstepm-1; h++)
      for(j=1;j<=cptcoveff;j++)        for(j=1; j<=nlstate*nlstate;j++)
        fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);          for(theta=1; theta <=npar; theta++)
      fprintf(ficresvpl,"******\n");            trgradg[h][j][theta]=gradg[h][theta][j];
            
      varpl=matrix(1,nlstate,(int) bage, (int) fage);  
      oldm=oldms;savm=savms;       for(ij=1;ij<=nlstate*nlstate;ij++)
      varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k);        for(ji=1;ji<=nlstate*nlstate;ji++)
    }          varhe[ij][ji][(int)age] =0.;
  }  
        printf("%d|",(int)age);fflush(stdout);
   fclose(ficresvpl);       fprintf(ficlog,"%d|",(int)age);fflush(ficlog);
        for(h=0;h<=nhstepm-1;h++){
   /*---------- End : free ----------------*/        for(k=0;k<=nhstepm-1;k++){
   free_matrix(varpl,1,nlstate,(int) bage, (int)fage);          matprod2(dnewm,trgradg[h],1,nlstate*nlstate,1,npar,1,npar,matcov);
            matprod2(doldm,dnewm,1,nlstate*nlstate,1,npar,1,nlstate*nlstate,gradg[k]);
   free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);          for(ij=1;ij<=nlstate*nlstate;ij++)
   free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);            for(ji=1;ji<=nlstate*nlstate;ji++)
                varhe[ij][ji][(int)age] += doldm[ij][ji]*hf*hf;
          }
   free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);      }
   free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);      /* Computing expectancies */
   free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);      hpxij(p3matm,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, cij);  
   free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);      for(i=1; i<=nlstate;i++)
          for(j=1; j<=nlstate;j++)
   free_matrix(matcov,1,npar,1,npar);          for (h=0, eij[i][j][(int)age]=0; h<=nhstepm-1; h++){
   free_vector(delti,1,npar);            eij[i][j][(int)age] += (p3matm[i][j][h]+p3matm[i][j][h+1])/2.0*hf;
              
   free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);            /* if((int)age==70)printf("i=%2d,j=%2d,h=%2d,age=%3d,%9.4f,%9.4f,%9.4f\n",i,j,h,(int)age,p3mat[i][j][h],hf,eij[i][j][(int)age]);*/
   
   printf("End of Imach\n");          }
   /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */  
        fprintf(ficresstdeij,"%3.0f",age );
   /* printf("Total time was %d Sec. %d uSec.\n", end_time.tv_sec -start_time.tv_sec, end_time.tv_usec -start_time.tv_usec);*/      for(i=1; i<=nlstate;i++){
   /*printf("Total time was %d uSec.\n", total_usecs);*/        eip=0.;
   /*------ End -----------*/        vip=0.;
         for(j=1; j<=nlstate;j++){
  end:          eip += eij[i][j][(int)age];
 #ifdef windows          for(k=1; k<=nlstate;k++) /* Sum on j and k of cov(eij,eik) */
  chdir(pathcd);            vip += varhe[(j-1)*nlstate+i][(k-1)*nlstate+i][(int)age];
 #endif          fprintf(ficresstdeij," %9.4f (%.4f)", eij[i][j][(int)age], sqrt(varhe[(j-1)*nlstate+i][(j-1)*nlstate+i][(int)age]) );
  system("wgnuplot graph.plt");        }
         fprintf(ficresstdeij," %9.4f (%.4f)", eip, sqrt(vip));
 #ifdef windows      }
   while (z[0] != 'q') {      fprintf(ficresstdeij,"\n");
     chdir(pathcd);  
     printf("\nType e to edit output files, c to start again, and q for exiting: ");      fprintf(ficrescveij,"%3.0f",age );
     scanf("%s",z);      for(i=1; i<=nlstate;i++)
     if (z[0] == 'c') system("./imach");        for(j=1; j<=nlstate;j++){
     else if (z[0] == 'e') {          cptj= (j-1)*nlstate+i;
       chdir(path);          for(i2=1; i2<=nlstate;i2++)
       system("index.htm");            for(j2=1; j2<=nlstate;j2++){
     }              cptj2= (j2-1)*nlstate+i2;
     else if (z[0] == 'q') exit(0);              if(cptj2 <= cptj)
   }                fprintf(ficrescveij," %.4f", varhe[cptj][cptj2][(int)age]);
 #endif            }
 }        }
       fprintf(ficrescveij,"\n");
      
     }
     free_matrix(gm,0,nhstepm,1,nlstate*nlstate);
     free_matrix(gp,0,nhstepm,1,nlstate*nlstate);
     free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate*nlstate);
     free_ma3x(trgradg,0,nhstepm,1,nlstate*nlstate,1,npar);
     free_ma3x(p3matm,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     free_ma3x(p3matp,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     printf("\n");
     fprintf(ficlog,"\n");
   
     free_vector(xm,1,npar);
     free_vector(xp,1,npar);
     free_matrix(dnewm,1,nlstate*nlstate,1,npar);
     free_matrix(doldm,1,nlstate*nlstate,1,nlstate*nlstate);
     free_ma3x(varhe,1,nlstate*nlstate,1,nlstate*nlstate,(int) bage, (int)fage);
   }
   
   /************ Variance ******************/
   void varevsij(char optionfilefiname[], double ***vareij, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, int estepm, int cptcov, int cptcod, int popbased, int mobilav, char strstart[])
   {
     /* Variance of health expectancies */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double ** savm,double ftolpl);*/
     /* double **newm;*/
     double **dnewm,**doldm;
     double **dnewmp,**doldmp;
     int i, j, nhstepm, hstepm, h, nstepm ;
     int k, cptcode;
     double *xp;
     double **gp, **gm;  /* for var eij */
     double ***gradg, ***trgradg; /*for var eij */
     double **gradgp, **trgradgp; /* for var p point j */
     double *gpp, *gmp; /* for var p point j */
     double **varppt; /* for var p point j nlstate to nlstate+ndeath */
     double ***p3mat;
     double age,agelim, hf;
     double ***mobaverage;
     int theta;
     char digit[4];
     char digitp[25];
   
     char fileresprobmorprev[FILENAMELENGTH];
   
     if(popbased==1){
       if(mobilav!=0)
         strcpy(digitp,"-populbased-mobilav-");
       else strcpy(digitp,"-populbased-nomobil-");
     }
     else 
       strcpy(digitp,"-stablbased-");
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     strcpy(fileresprobmorprev,"prmorprev"); 
     sprintf(digit,"%-d",ij);
     /*printf("DIGIT=%s, ij=%d ijr=%-d|\n",digit, ij,ij);*/
     strcat(fileresprobmorprev,digit); /* Tvar to be done */
     strcat(fileresprobmorprev,digitp); /* Popbased or not, mobilav or not */
     strcat(fileresprobmorprev,fileres);
     if((ficresprobmorprev=fopen(fileresprobmorprev,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobmorprev);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobmorprev);
     }
     printf("Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
    
     fprintf(ficlog,"Computing total mortality p.j=w1*p1j+w2*p2j+..: result on file '%s' \n",fileresprobmorprev);
     pstamp(ficresprobmorprev);
     fprintf(ficresprobmorprev,"# probabilities of dying before estepm=%d months for people of exact age and weighted probabilities w1*p1j+w2*p2j+... stand dev in()\n",estepm);
     fprintf(ficresprobmorprev,"# Age cov=%-d",ij);
     for(j=nlstate+1; j<=(nlstate+ndeath);j++){
       fprintf(ficresprobmorprev," p.%-d SE",j);
       for(i=1; i<=nlstate;i++)
         fprintf(ficresprobmorprev," w%1d p%-d%-d",i,i,j);
     }  
     fprintf(ficresprobmorprev,"\n");
     fprintf(ficgp,"\n# Routine varevsij");
     /* fprintf(fichtm, "#Local time at start: %s", strstart);*/
     fprintf(fichtm,"\n<li><h4> Computing probabilities of dying over estepm months as a weighted average (i.e global mortality independent of initial healh state)</h4></li>\n");
     fprintf(fichtm,"\n<br>%s  <br>\n",digitp);
   /*   } */
     varppt = matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     pstamp(ficresvij);
     fprintf(ficresvij,"# Variance and covariance of health expectancies e.j \n#  (weighted average of eij where weights are ");
     if(popbased==1)
       fprintf(ficresvij,"the age specific prevalence observed in the population i.e cross-sectionally\n in each health state (popbased=1)");
     else
       fprintf(ficresvij,"the age specific period (stable) prevalences in each health state \n");
     fprintf(ficresvij,"# Age");
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=nlstate;j++)
         fprintf(ficresvij," Cov(e.%1d, e.%1d)",i,j);
     fprintf(ficresvij,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     dnewmp= matrix(nlstate+1,nlstate+ndeath,1,npar);
     doldmp= matrix(nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
   
     gradgp=matrix(1,npar,nlstate+1,nlstate+ndeath);
     gpp=vector(nlstate+1,nlstate+ndeath);
     gmp=vector(nlstate+1,nlstate+ndeath);
     trgradgp =matrix(nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
     /* For example we decided to compute the life expectancy with the smallest unit */
     /* hstepm beeing the number of stepms, if hstepm=1 the length of hstepm is stepm. 
        nhstepm is the number of hstepm from age to agelim 
        nstepm is the number of stepm from age to agelin. 
        Look at hpijx to understand the reason of that which relies in memory size
        and note for a fixed period like k years */
     /* We decided (b) to get a life expectancy respecting the most precise curvature of the
        survival function given by stepm (the optimization length). Unfortunately it
        means that if the survival funtion is printed every two years of age and if
        you sum them up and add 1 year (area under the trapezoids) you won't get the same 
        results. So we changed our mind and took the option of the best precision.
     */
     hstepm=hstepm/stepm; /* Typically in stepm units, if stepm=6 & estepm=24 , = 24/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       nhstepm = nstepm/hstepm;/* Expressed in hstepm, typically nhstepm=40/4=10 */
       p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
       gradg=ma3x(0,nhstepm,1,npar,1,nlstate);
       gp=matrix(0,nhstepm,1,nlstate);
       gm=matrix(0,nhstepm,1,nlstate);
   
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient x + delta*/
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
   
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
     
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gp[h][j]=0.;i<=nlstate;i++)
               gp[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gpp[j]=0.; i<= nlstate; i++)
             gpp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(i=1; i<=npar; i++) /* Computes gradient x - delta */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         hpxij(p3mat,nhstepm,age,hstepm,xp,nlstate,stepm,oldm,savm, ij);  
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
    
         if (popbased==1) {
           if(mobilav ==0){
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=probs[(int)age][i][ij];
           }else{ /* mobilav */ 
             for(i=1; i<=nlstate;i++)
               prlim[i][i]=mobaverage[(int)age][i][ij];
           }
         }
   
         for(j=1; j<= nlstate; j++){
           for(h=0; h<=nhstepm; h++){
             for(i=1, gm[h][j]=0.;i<=nlstate;i++)
               gm[h][j] += prlim[i][i]*p3mat[i][j][h];
           }
         }
         /* This for computing probability of death (h=1 means
            computed over hstepm matrices product = hstepm*stepm months) 
            as a weighted average of prlim.
         */
         for(j=nlstate+1;j<=nlstate+ndeath;j++){
           for(i=1,gmp[j]=0.; i<= nlstate; i++)
            gmp[j] += prlim[i][i]*p3mat[i][j][1];
         }    
         /* end probability of death */
   
         for(j=1; j<= nlstate; j++) /* vareij */
           for(h=0; h<=nhstepm; h++){
             gradg[h][theta][j]= (gp[h][j]-gm[h][j])/2./delti[theta];
           }
   
         for(j=nlstate+1; j<= nlstate+ndeath; j++){ /* var mu */
           gradgp[theta][j]= (gpp[j]-gmp[j])/2./delti[theta];
         }
   
       } /* End theta */
   
       trgradg =ma3x(0,nhstepm,1,nlstate,1,npar); /* veij */
   
       for(h=0; h<=nhstepm; h++) /* veij */
         for(j=1; j<=nlstate;j++)
           for(theta=1; theta <=npar; theta++)
             trgradg[h][j][theta]=gradg[h][theta][j];
   
       for(j=nlstate+1; j<=nlstate+ndeath;j++) /* mu */
         for(theta=1; theta <=npar; theta++)
           trgradgp[j][theta]=gradgp[theta][j];
     
   
       hf=hstepm*stepm/YEARM;  /* Duration of hstepm expressed in year unit. */
       for(i=1;i<=nlstate;i++)
         for(j=1;j<=nlstate;j++)
           vareij[i][j][(int)age] =0.;
   
       for(h=0;h<=nhstepm;h++){
         for(k=0;k<=nhstepm;k++){
           matprod2(dnewm,trgradg[h],1,nlstate,1,npar,1,npar,matcov);
           matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg[k]);
           for(i=1;i<=nlstate;i++)
             for(j=1;j<=nlstate;j++)
               vareij[i][j][(int)age] += doldm[i][j]*hf*hf;
         }
       }
     
       /* pptj */
       matprod2(dnewmp,trgradgp,nlstate+1,nlstate+ndeath,1,npar,1,npar,matcov);
       matprod2(doldmp,dnewmp,nlstate+1,nlstate+ndeath,1,npar,nlstate+1,nlstate+ndeath,gradgp);
       for(j=nlstate+1;j<=nlstate+ndeath;j++)
         for(i=nlstate+1;i<=nlstate+ndeath;i++)
           varppt[j][i]=doldmp[j][i];
       /* end ppptj */
       /*  x centered again */
       hpxij(p3mat,nhstepm,age,hstepm,x,nlstate,stepm,oldm,savm, ij);  
       prevalim(prlim,nlstate,x,age,oldm,savm,ftolpl,ij);
    
       if (popbased==1) {
         if(mobilav ==0){
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=probs[(int)age][i][ij];
         }else{ /* mobilav */ 
           for(i=1; i<=nlstate;i++)
             prlim[i][i]=mobaverage[(int)age][i][ij];
         }
       }
                
       /* This for computing probability of death (h=1 means
          computed over hstepm (estepm) matrices product = hstepm*stepm months) 
          as a weighted average of prlim.
       */
       for(j=nlstate+1;j<=nlstate+ndeath;j++){
         for(i=1,gmp[j]=0.;i<= nlstate; i++) 
           gmp[j] += prlim[i][i]*p3mat[i][j][1]; 
       }    
       /* end probability of death */
   
       fprintf(ficresprobmorprev,"%3d %d ",(int) age, ij);
       for(j=nlstate+1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprobmorprev," %11.3e %11.3e",gmp[j], sqrt(varppt[j][j]));
         for(i=1; i<=nlstate;i++){
           fprintf(ficresprobmorprev," %11.3e %11.3e ",prlim[i][i],p3mat[i][j][1]);
         }
       } 
       fprintf(ficresprobmorprev,"\n");
   
       fprintf(ficresvij,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         for(j=1; j<=nlstate;j++){
           fprintf(ficresvij," %.4f", vareij[i][j][(int)age]);
         }
       fprintf(ficresvij,"\n");
       free_matrix(gp,0,nhstepm,1,nlstate);
       free_matrix(gm,0,nhstepm,1,nlstate);
       free_ma3x(gradg,0,nhstepm,1,npar,1,nlstate);
       free_ma3x(trgradg,0,nhstepm,1,nlstate,1,npar);
       free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
     } /* End age */
     free_vector(gpp,nlstate+1,nlstate+ndeath);
     free_vector(gmp,nlstate+1,nlstate+ndeath);
     free_matrix(gradgp,1,npar,nlstate+1,nlstate+ndeath);
     free_matrix(trgradgp,nlstate+1,nlstate+ndeath,1,npar); /* mu or p point j*/
     fprintf(ficgp,"\nset noparametric;set nolabel; set ter png small;set size 0.65, 0.65");
     /* for(j=nlstate+1; j<= nlstate+ndeath; j++){ *//* Only the first actually */
     fprintf(ficgp,"\n set log y; set nolog x;set xlabel \"Age\"; set ylabel \"Force of mortality (year-1)\";");
   /*   fprintf(ficgp,"\n plot \"%s\"  u 1:($3*%6.3f) not w l 1 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)*%6.3f) t \"95\%% interval\" w l 2 ",fileresprobmorprev,YEARM/estepm); */
   /*   fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)*%6.3f) not w l 2 ",fileresprobmorprev,YEARM/estepm); */
     fprintf(ficgp,"\n plot \"%s\"  u 1:($3) not w l 1 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3+1.96*$4)) t \"95\%% interval\" w l 2 ",subdirf(fileresprobmorprev));
     fprintf(ficgp,"\n replot \"%s\"  u 1:(($3-1.96*$4)) not w l 2 ",subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> File (multiple files are possible if covariates are present): <A href=\"%s\">%s</a>\n",subdirf(fileresprobmorprev),subdirf(fileresprobmorprev));
     fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months. <br> <img src=\"%s%s.png\"> <br>\n", estepm,subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
     /*  fprintf(fichtm,"\n<br> Probability is computed over estepm=%d months and then divided by estepm and multiplied by %.0f in order to have the probability to die over a year <br> <img src=\"varmuptjgr%s%s.png\"> <br>\n", stepm,YEARM,digitp,digit);
   */
   /*   fprintf(ficgp,"\nset out \"varmuptjgr%s%s%s.png\";replot;",digitp,optionfilefiname,digit); */
     fprintf(ficgp,"\nset out \"%s%s.png\";replot;\n",subdirf3(optionfilefiname,"varmuptjgr",digitp),digit);
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,nlstate);
     free_matrix(dnewm,1,nlstate,1,npar);
     free_matrix(doldmp,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     free_matrix(dnewmp,nlstate+1,nlstate+ndeath,1,npar);
     free_matrix(varppt,nlstate+1,nlstate+ndeath,nlstate+1,nlstate+ndeath);
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficresprobmorprev);
     fflush(ficgp);
     fflush(fichtm); 
   }  /* end varevsij */
   
   /************ Variance of prevlim ******************/
   void varprevlim(char fileres[], double **varpl, double **matcov, double x[], double delti[], int nlstate, int stepm, double bage, double fage, double **oldm, double **savm, double **prlim, double ftolpl, int ij, char strstart[])
   {
     /* Variance of prevalence limit */
     /*  double **prevalim(double **prlim, int nlstate, double *xp, double age, double **oldm, double **savm,double ftolpl);*/
     double **newm;
     double **dnewm,**doldm;
     int i, j, nhstepm, hstepm;
     int k, cptcode;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double age,agelim;
     int theta;
     
     pstamp(ficresvpl);
     fprintf(ficresvpl,"# Standard deviation of period (stable) prevalences \n");
     fprintf(ficresvpl,"# Age");
     for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %1d-%1d",i,i);
     fprintf(ficresvpl,"\n");
   
     xp=vector(1,npar);
     dnewm=matrix(1,nlstate,1,npar);
     doldm=matrix(1,nlstate,1,nlstate);
     
     hstepm=1*YEARM; /* Every year of age */
     hstepm=hstepm/stepm; /* Typically in stepm units, if j= 2 years, = 2/6 months = 4 */ 
     agelim = AGESUP;
     for (age=bage; age<=fage; age ++){ /* If stepm=6 months */
       nhstepm=(int) rint((agelim-age)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
       if (stepm >= YEARM) hstepm=1;
       nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
       gradg=matrix(1,npar,1,nlstate);
       gp=vector(1,nlstate);
       gm=vector(1,nlstate);
   
       for(theta=1; theta <=npar; theta++){
         for(i=1; i<=npar; i++){ /* Computes gradient */
           xp[i] = x[i] + (i==theta ?delti[theta]:0);
         }
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gp[i] = prlim[i][i];
       
         for(i=1; i<=npar; i++) /* Computes gradient */
           xp[i] = x[i] - (i==theta ?delti[theta]:0);
         prevalim(prlim,nlstate,xp,age,oldm,savm,ftolpl,ij);
         for(i=1;i<=nlstate;i++)
           gm[i] = prlim[i][i];
   
         for(i=1;i<=nlstate;i++)
           gradg[theta][i]= (gp[i]-gm[i])/2./delti[theta];
       } /* End theta */
   
       trgradg =matrix(1,nlstate,1,npar);
   
       for(j=1; j<=nlstate;j++)
         for(theta=1; theta <=npar; theta++)
           trgradg[j][theta]=gradg[theta][j];
   
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] =0.;
       matprod2(dnewm,trgradg,1,nlstate,1,npar,1,npar,matcov);
       matprod2(doldm,dnewm,1,nlstate,1,npar,1,nlstate,gradg);
       for(i=1;i<=nlstate;i++)
         varpl[i][(int)age] = doldm[i][i]; /* Covariances are useless */
   
       fprintf(ficresvpl,"%.0f ",age );
       for(i=1; i<=nlstate;i++)
         fprintf(ficresvpl," %.5f (%.5f)",prlim[i][i],sqrt(varpl[i][(int)age]));
       fprintf(ficresvpl,"\n");
       free_vector(gp,1,nlstate);
       free_vector(gm,1,nlstate);
       free_matrix(gradg,1,npar,1,nlstate);
       free_matrix(trgradg,1,nlstate,1,npar);
     } /* End age */
   
     free_vector(xp,1,npar);
     free_matrix(doldm,1,nlstate,1,npar);
     free_matrix(dnewm,1,nlstate,1,nlstate);
   
   }
   
   /************ Variance of one-step probabilities  ******************/
   void varprob(char optionfilefiname[], double **matcov, double x[], double delti[], int nlstate, double bage, double fage, int ij, int *Tvar, int **nbcode, int *ncodemax, char strstart[])
   {
     int i, j=0,  i1, k1, l1, t, tj;
     int k2, l2, j1,  z1;
     int k=0,l, cptcode;
     int first=1, first1;
     double cv12, mu1, mu2, lc1, lc2, v12, v21, v11, v22,v1,v2, c12, tnalp;
     double **dnewm,**doldm;
     double *xp;
     double *gp, *gm;
     double **gradg, **trgradg;
     double **mu;
     double age,agelim, cov[NCOVMAX];
     double std=2.0; /* Number of standard deviation wide of confidence ellipsoids */
     int theta;
     char fileresprob[FILENAMELENGTH];
     char fileresprobcov[FILENAMELENGTH];
     char fileresprobcor[FILENAMELENGTH];
   
     double ***varpij;
   
     strcpy(fileresprob,"prob"); 
     strcat(fileresprob,fileres);
     if((ficresprob=fopen(fileresprob,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprob);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprob);
     }
     strcpy(fileresprobcov,"probcov"); 
     strcat(fileresprobcov,fileres);
     if((ficresprobcov=fopen(fileresprobcov,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcov);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcov);
     }
     strcpy(fileresprobcor,"probcor"); 
     strcat(fileresprobcor,fileres);
     if((ficresprobcor=fopen(fileresprobcor,"w"))==NULL) {
       printf("Problem with resultfile: %s\n", fileresprobcor);
       fprintf(ficlog,"Problem with resultfile: %s\n", fileresprobcor);
     }
     printf("Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     fprintf(ficlog,"Computing standard deviation of one-step probabilities: result on file '%s' \n",fileresprob);
     printf("Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     fprintf(ficlog,"Computing matrix of variance covariance of one-step probabilities: result on file '%s' \n",fileresprobcov);
     printf("and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     fprintf(ficlog,"and correlation matrix of one-step probabilities: result on file '%s' \n",fileresprobcor);
     pstamp(ficresprob);
     fprintf(ficresprob,"#One-step probabilities and stand. devi in ()\n");
     fprintf(ficresprob,"# Age");
     pstamp(ficresprobcov);
     fprintf(ficresprobcov,"#One-step probabilities and covariance matrix\n");
     fprintf(ficresprobcov,"# Age");
     pstamp(ficresprobcor);
     fprintf(ficresprobcor,"#One-step probabilities and correlation matrix\n");
     fprintf(ficresprobcor,"# Age");
   
   
     for(i=1; i<=nlstate;i++)
       for(j=1; j<=(nlstate+ndeath);j++){
         fprintf(ficresprob," p%1d-%1d (SE)",i,j);
         fprintf(ficresprobcov," p%1d-%1d ",i,j);
         fprintf(ficresprobcor," p%1d-%1d ",i,j);
       }  
    /* fprintf(ficresprob,"\n");
     fprintf(ficresprobcov,"\n");
     fprintf(ficresprobcor,"\n");
    */
    xp=vector(1,npar);
     dnewm=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
     doldm=matrix(1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     mu=matrix(1,(nlstate)*(nlstate+ndeath), (int) bage, (int)fage);
     varpij=ma3x(1,nlstate*(nlstate+ndeath),1,nlstate*(nlstate+ndeath),(int) bage, (int) fage);
     first=1;
     fprintf(ficgp,"\n# Routine varprob");
     fprintf(fichtm,"\n<li><h4> Computing and drawing one step probabilities with their confidence intervals</h4></li>\n");
     fprintf(fichtm,"\n");
   
     fprintf(fichtm,"\n<li><h4> <a href=\"%s\">Matrix of variance-covariance of pairs of step probabilities (drawings)</a></h4></li>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\n<h4>Matrix of variance-covariance of pairs of step probabilities</h4>\n\
     file %s<br>\n",optionfilehtmcov);
     fprintf(fichtmcov,"\nEllipsoids of confidence centered on point (p<inf>ij</inf>, p<inf>kl</inf>) are estimated\
   and drawn. It helps understanding how is the covariance between two incidences.\
    They are expressed in year<sup>-1</sup> in order to be less dependent of stepm.<br>\n");
     fprintf(fichtmcov,"\n<br> Contour plot corresponding to x'cov<sup>-1</sup>x = 4 (where x is the column vector (pij,pkl)) are drawn. \
   It can be understood this way: if pij and pkl where uncorrelated the (2x2) matrix of covariance \
   would have been (1/(var pij), 0 , 0, 1/(var pkl)), and the confidence interval would be 2 \
   standard deviations wide on each axis. <br>\
    Now, if both incidences are correlated (usual case) we diagonalised the inverse of the covariance matrix\
    and made the appropriate rotation to look at the uncorrelated principal directions.<br>\
   To be simple, these graphs help to understand the significativity of each parameter in relation to a second other one.<br> \n");
   
     cov[1]=1;
     tj=cptcoveff;
     if (cptcovn<1) {tj=1;ncodemax[1]=1;}
     j1=0;
     for(t=1; t<=tj;t++){
       for(i1=1; i1<=ncodemax[t];i1++){ 
         j1++;
         if  (cptcovn>0) {
           fprintf(ficresprob, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprob, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprob, "**********\n#\n");
           fprintf(ficresprobcov, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcov, "**********\n#\n");
           
           fprintf(ficgp, "\n#********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficgp, " V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficgp, "**********\n#\n");
           
           
           fprintf(fichtmcov, "\n<hr  size=\"2\" color=\"#EC5E5E\">********** Variable "); 
           for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(fichtmcov, "**********\n<hr size=\"2\" color=\"#EC5E5E\">");
           
           fprintf(ficresprobcor, "\n#********** Variable ");    
           for (z1=1; z1<=cptcoveff; z1++) fprintf(ficresprobcor, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtab[j1][z1]]);
           fprintf(ficresprobcor, "**********\n#");    
         }
         
         for (age=bage; age<=fage; age ++){ 
           cov[2]=age;
           for (k=1; k<=cptcovn;k++) {
             cov[2+k]=nbcode[Tvar[k]][codtab[j1][Tvar[k]]];
           }
           for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2];
           for (k=1; k<=cptcovprod;k++)
             cov[2+Tprod[k]]=nbcode[Tvard[k][1]][codtab[ij][Tvard[k][1]]]*nbcode[Tvard[k][2]][codtab[ij][Tvard[k][2]]];
           
           gradg=matrix(1,npar,1,(nlstate)*(nlstate+ndeath));
           trgradg=matrix(1,(nlstate)*(nlstate+ndeath),1,npar);
           gp=vector(1,(nlstate)*(nlstate+ndeath));
           gm=vector(1,(nlstate)*(nlstate+ndeath));
       
           for(theta=1; theta <=npar; theta++){
             for(i=1; i<=npar; i++)
               xp[i] = x[i] + (i==theta ?delti[theta]:(double)0);
             
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             
             k=0;
             for(i=1; i<= (nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gp[k]=pmmij[i][j];
               }
             }
             
             for(i=1; i<=npar; i++)
               xp[i] = x[i] - (i==theta ?delti[theta]:(double)0);
       
             pmij(pmmij,cov,ncovmodel,xp,nlstate);
             k=0;
             for(i=1; i<=(nlstate); i++){
               for(j=1; j<=(nlstate+ndeath);j++){
                 k=k+1;
                 gm[k]=pmmij[i][j];
               }
             }
        
             for(i=1; i<= (nlstate)*(nlstate+ndeath); i++) 
               gradg[theta][i]=(gp[i]-gm[i])/(double)2./delti[theta];  
           }
   
           for(j=1; j<=(nlstate)*(nlstate+ndeath);j++)
             for(theta=1; theta <=npar; theta++)
               trgradg[j][theta]=gradg[theta][j];
           
           matprod2(dnewm,trgradg,1,(nlstate)*(nlstate+ndeath),1,npar,1,npar,matcov); 
           matprod2(doldm,dnewm,1,(nlstate)*(nlstate+ndeath),1,npar,1,(nlstate)*(nlstate+ndeath),gradg);
           free_vector(gp,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_vector(gm,1,(nlstate+ndeath)*(nlstate+ndeath));
           free_matrix(trgradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
           free_matrix(gradg,1,(nlstate+ndeath)*(nlstate+ndeath),1,npar);
   
           pmij(pmmij,cov,ncovmodel,x,nlstate);
           
           k=0;
           for(i=1; i<=(nlstate); i++){
             for(j=1; j<=(nlstate+ndeath);j++){
               k=k+1;
               mu[k][(int) age]=pmmij[i][j];
             }
           }
           for(i=1;i<=(nlstate)*(nlstate+ndeath);i++)
             for(j=1;j<=(nlstate)*(nlstate+ndeath);j++)
               varpij[i][j][(int)age] = doldm[i][j];
   
           /*printf("\n%d ",(int)age);
             for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             printf("%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             fprintf(ficlog,"%e [%e ;%e] ",gm[i],gm[i]-2*sqrt(doldm[i][i]),gm[i]+2*sqrt(doldm[i][i]));
             }*/
   
           fprintf(ficresprob,"\n%d ",(int)age);
           fprintf(ficresprobcov,"\n%d ",(int)age);
           fprintf(ficresprobcor,"\n%d ",(int)age);
   
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++)
             fprintf(ficresprob,"%11.3e (%11.3e) ",mu[i][(int) age],sqrt(varpij[i][i][(int)age]));
           for (i=1; i<=(nlstate)*(nlstate+ndeath);i++){
             fprintf(ficresprobcov,"%11.3e ",mu[i][(int) age]);
             fprintf(ficresprobcor,"%11.3e ",mu[i][(int) age]);
           }
           i=0;
           for (k=1; k<=(nlstate);k++){
             for (l=1; l<=(nlstate+ndeath);l++){ 
               i=i++;
               fprintf(ficresprobcov,"\n%d %d-%d",(int)age,k,l);
               fprintf(ficresprobcor,"\n%d %d-%d",(int)age,k,l);
               for (j=1; j<=i;j++){
                 fprintf(ficresprobcov," %11.3e",varpij[i][j][(int)age]);
                 fprintf(ficresprobcor," %11.3e",varpij[i][j][(int) age]/sqrt(varpij[i][i][(int) age])/sqrt(varpij[j][j][(int)age]));
               }
             }
           }/* end of loop for state */
         } /* end of loop for age */
   
         /* Confidence intervalle of pij  */
         /*
           fprintf(ficgp,"\nset noparametric;unset label");
           fprintf(ficgp,"\nset log y;unset log x; set xlabel \"Age\";set ylabel \"probability (year-1)\"");
           fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
           fprintf(fichtm,"\n<br>Probability with  confidence intervals expressed in year<sup>-1</sup> :<a href=\"pijgr%s.png\">pijgr%s.png</A>, ",optionfilefiname,optionfilefiname);
           fprintf(fichtm,"\n<br><img src=\"pijgr%s.png\"> ",optionfilefiname);
           fprintf(ficgp,"\nset out \"pijgr%s.png\"",optionfilefiname);
           fprintf(ficgp,"\nplot \"%s\" every :::%d::%d u 1:2 \"\%%lf",k1,k2,xfilevarprob);
         */
   
         /* Drawing ellipsoids of confidence of two variables p(k1-l1,k2-l2)*/
         first1=1;
         for (k2=1; k2<=(nlstate);k2++){
           for (l2=1; l2<=(nlstate+ndeath);l2++){ 
             if(l2==k2) continue;
             j=(k2-1)*(nlstate+ndeath)+l2;
             for (k1=1; k1<=(nlstate);k1++){
               for (l1=1; l1<=(nlstate+ndeath);l1++){ 
                 if(l1==k1) continue;
                 i=(k1-1)*(nlstate+ndeath)+l1;
                 if(i<=j) continue;
                 for (age=bage; age<=fage; age ++){ 
                   if ((int)age %5==0){
                     v1=varpij[i][i][(int)age]/stepm*YEARM/stepm*YEARM;
                     v2=varpij[j][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     cv12=varpij[i][j][(int)age]/stepm*YEARM/stepm*YEARM;
                     mu1=mu[i][(int) age]/stepm*YEARM ;
                     mu2=mu[j][(int) age]/stepm*YEARM;
                     c12=cv12/sqrt(v1*v2);
                     /* Computing eigen value of matrix of covariance */
                     lc1=((v1+v2)+sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     lc2=((v1+v2)-sqrt((v1+v2)*(v1+v2) - 4*(v1*v2-cv12*cv12)))/2.;
                     /* Eigen vectors */
                     v11=(1./sqrt(1+(v1-lc1)*(v1-lc1)/cv12/cv12));
                     /*v21=sqrt(1.-v11*v11); *//* error */
                     v21=(lc1-v1)/cv12*v11;
                     v12=-v21;
                     v22=v11;
                     tnalp=v21/v11;
                     if(first1==1){
                       first1=0;
                       printf("%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tang %.3f\nOthers in log...\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     }
                     fprintf(ficlog,"%d %d%d-%d%d mu %.4e %.4e Var %.4e %.4e cor %.3f cov %.4e Eig %.3e %.3e 1stv %.3f %.3f tan %.3f\n",(int) age,k1,l1,k2,l2,mu1,mu2,v1,v2,c12,cv12,lc1,lc2,v11,v21,tnalp);
                     /*printf(fignu*/
                     /* mu1+ v11*lc1*cost + v12*lc2*sin(t) */
                     /* mu2+ v21*lc1*cost + v22*lc2*sin(t) */
                     if(first==1){
                       first=0;
                       fprintf(ficgp,"\nset parametric;unset label");
                       fprintf(ficgp,"\nset log y;set log x; set xlabel \"p%1d%1d (year-1)\";set ylabel \"p%1d%1d (year-1)\"",k1,l1,k2,l2);
                       fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65");
                       fprintf(fichtmcov,"\n<br>Ellipsoids of confidence cov(p%1d%1d,p%1d%1d) expressed in year<sup>-1</sup>\
    :<a href=\"%s%d%1d%1d-%1d%1d.png\">\
   %s%d%1d%1d-%1d%1d.png</A>, ",k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2,\
                               subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br><img src=\"%s%d%1d%1d-%1d%1d.png\"> ",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(fichtmcov,"\n<br> Correlation at age %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\"",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nplot [-pi:pi] %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }else{
                       first=0;
                       fprintf(fichtmcov," %d (%.3f),",(int) age, c12);
                       fprintf(ficgp,"\n# Age %d, p%1d%1d - p%1d%1d",(int) age, k1,l1,k2,l2);
                       fprintf(ficgp,"\nset label \"%d\" at %11.3e,%11.3e center",(int) age, mu1,mu2);
                       fprintf(ficgp,"\nreplot %11.3e+ %.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)), %11.3e +%.3f*(%11.3e*%11.3e*cos(t)+%11.3e*%11.3e*sin(t)) not",\
                               mu1,std,v11,sqrt(lc1),v12,sqrt(lc2),\
                               mu2,std,v21,sqrt(lc1),v22,sqrt(lc2));
                     }/* if first */
                   } /* age mod 5 */
                 } /* end loop age */
                 fprintf(ficgp,"\nset out \"%s%d%1d%1d-%1d%1d.png\";replot;",subdirf2(optionfilefiname,"varpijgr"), j1,k1,l1,k2,l2);
                 first=1;
               } /*l12 */
             } /* k12 */
           } /*l1 */
         }/* k1 */
       } /* loop covariates */
     }
     free_ma3x(varpij,1,nlstate,1,nlstate+ndeath,(int) bage, (int)fage);
     free_matrix(mu,1,(nlstate+ndeath)*(nlstate+ndeath),(int) bage, (int)fage);
     free_matrix(doldm,1,(nlstate)*(nlstate+ndeath),1,(nlstate)*(nlstate+ndeath));
     free_matrix(dnewm,1,(nlstate)*(nlstate+ndeath),1,npar);
     free_vector(xp,1,npar);
     fclose(ficresprob);
     fclose(ficresprobcov);
     fclose(ficresprobcor);
     fflush(ficgp);
     fflush(fichtmcov);
   }
   
   
   /******************* Printing html file ***********/
   void printinghtml(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,int jmin, int jmax, double jmeanint,char rfileres[],\
                     int popforecast, int estepm ,\
                     double jprev1, double mprev1,double anprev1, \
                     double jprev2, double mprev2,double anprev2){
     int jj1, k1, i1, cpt;
   
      fprintf(fichtm,"<ul><li><a href='#firstorder'>Result files (first order: no variance)</a>\n \
      <li><a href='#secondorder'>Result files (second order (variance)</a>\n \
   </ul>");
      fprintf(fichtm,"<ul><li><h4><a name='firstorder'>Result files (first order: no variance)</a></h4>\n \
    - Observed prevalence in each state (during the period defined between %.lf/%.lf/%.lf and %.lf/%.lf/%.lf): <a href=\"%s\">%s</a> <br>\n ",
              jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,subdirf2(fileres,"p"),subdirf2(fileres,"p"));
      fprintf(fichtm,"\
    - Estimated transition probabilities over %d (stepm) months: <a href=\"%s\">%s</a><br>\n ",
              stepm,subdirf2(fileres,"pij"),subdirf2(fileres,"pij"));
      fprintf(fichtm,"\
    - Period (stable) prevalence in each health state: <a href=\"%s\">%s</a> <br>\n",
              subdirf2(fileres,"pl"),subdirf2(fileres,"pl"));
      fprintf(fichtm,"\
    - (a) Life expectancies by health status at initial age, (b) health expectancies by health status at initial age:  ei., eij (estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"e"),subdirf2(fileres,"e"));
   
   
   fprintf(fichtm," \n<ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        /* Pij */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i, %d (stepm) months before: <a href=\"%s%d1.png\">%s%d1.png</a><br> \
   <img src=\"%s%d1.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1);     
        /* Quasi-incidences */
        fprintf(fichtm,"<br>- Pij or Conditional probabilities to be observed in state j being in state i %d (stepm) months\
    before but expressed in per year i.e. quasi incidences if stepm is small and probabilities too: <a href=\"%s%d2.png\">%s%d2.png</a><br> \
   <img src=\"%s%d2.png\">",stepm,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1,subdirf2(optionfilefiname,"pe"),jj1); 
          /* Period (stable) prevalence in each health state */
          for(cpt=1; cpt<nlstate;cpt++){
            fprintf(fichtm,"<br>- Period (stable) prevalence in each health state : <a href=\"%s%d%d.png\">%s%d%d.png</a><br> \
   <img src=\"%s%d%d.png\">",subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1,subdirf2(optionfilefiname,"p"),cpt,jj1);
          }
        for(cpt=1; cpt<=nlstate;cpt++) {
           fprintf(fichtm,"\n<br>- Life expectancy by health state (%d) at initial age and its decomposition into health expectancies : <a href=\"%s%d%d.png\">%s%d%d.png</a> <br> \
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1,subdirf2(optionfilefiname,"exp"),cpt,jj1);
        }
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
   
   
    fprintf(fichtm,"\
   \n<br><li><h4> <a name='secondorder'>Result files (second order: variances)</a></h4>\n\
    - Parameter file with estimated parameters and covariance matrix: <a href=\"%s\">%s</a> <br>\n", rfileres,rfileres);
   
    fprintf(fichtm," - Variance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"prob"),subdirf2(fileres,"prob"));
    fprintf(fichtm,"\
    - Variance-covariance of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcov"),subdirf2(fileres,"probcov"));
   
    fprintf(fichtm,"\
    - Correlation matrix of one-step probabilities: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"probcor"),subdirf2(fileres,"probcor"));
    fprintf(fichtm,"\
    - Variances and covariances of health expectancies by age and <b>initial health status</b> (cov(e<sup>ij</sup>,e<sup>kl</sup>)(estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"cve"),subdirf2(fileres,"cve"));
    fprintf(fichtm,"\
    - (a) Health expectancies by health status at initial age (e<sup>ij</sup>) and standard errors (in parentheses) (b) life expectancies and standard errors (e<sup>i.</sup>=e<sup>i1</sup>+e<sup>i2</sup>+...)(estepm=%2d months): \
      <a href=\"%s\">%s</a> <br>\n</li>",
              estepm,subdirf2(fileres,"stde"),subdirf2(fileres,"stde"));
    fprintf(fichtm,"\
    - Variances and covariances of health expectancies by age. Status (i) based health expectancies (in state j), eij are weighted by the period prevalences in each state i (if popbased=1, an additional computation is done using the cross-sectional prevalences (i.e population based) (estepm=%d months): <a href=\"%s\">%s</a><br>\n",
            estepm, subdirf2(fileres,"v"),subdirf2(fileres,"v"));
    fprintf(fichtm,"\
    - Total life expectancy and total health expectancies to be spent in each health state e<sup>.j</sup> with their standard errors: <a href=\"%s\">%s</a> <br>\n",
            subdirf2(fileres,"t"),subdirf2(fileres,"t"));
    fprintf(fichtm,"\
    - Standard deviation of period (stable) prevalences: <a href=\"%s\">%s</a> <br>\n",\
            subdirf2(fileres,"vpl"),subdirf2(fileres,"vpl"));
   
   /*  if(popforecast==1) fprintf(fichtm,"\n */
   /*  - Prevalences forecasting: <a href=\"f%s\">f%s</a> <br>\n */
   /*  - Population forecasting (if popforecast=1): <a href=\"pop%s\">pop%s</a> <br>\n */
   /*      <br>",fileres,fileres,fileres,fileres); */
   /*  else  */
   /*    fprintf(fichtm,"\n No population forecast: popforecast = %d (instead of 1) or stepm = %d (instead of 1) or model=%s (instead of .)<br><br></li>\n",popforecast, stepm, model); */
    fflush(fichtm);
    fprintf(fichtm," <ul><li><b>Graphs</b></li><p>");
   
    m=cptcoveff;
    if (cptcovn < 1) {m=1;ncodemax[1]=1;}
   
    jj1=0;
    for(k1=1; k1<=m;k1++){
      for(i1=1; i1<=ncodemax[k1];i1++){
        jj1++;
        if (cptcovn > 0) {
          fprintf(fichtm,"<hr  size=\"2\" color=\"#EC5E5E\">************ Results for covariates");
          for (cpt=1; cpt<=cptcoveff;cpt++) 
            fprintf(fichtm," V%d=%d ",Tvaraff[cpt],nbcode[Tvaraff[cpt]][codtab[jj1][cpt]]);
          fprintf(fichtm," ************\n<hr size=\"2\" color=\"#EC5E5E\">");
        }
        for(cpt=1; cpt<=nlstate;cpt++) {
          fprintf(fichtm,"<br>- Observed (cross-sectional) and period (incidence based) \
   prevalence (with 95%% confidence interval) in state (%d): %s%d%d.png <br>\
   <img src=\"%s%d%d.png\">",cpt,subdirf2(optionfilefiname,"v"),cpt,jj1,subdirf2(optionfilefiname,"v"),cpt,jj1);  
        }
        fprintf(fichtm,"\n<br>- Total life expectancy by age and \
   health expectancies in states (1) and (2): %s%d.png<br>\
   <img src=\"%s%d.png\">",subdirf2(optionfilefiname,"e"),jj1,subdirf2(optionfilefiname,"e"),jj1);
      } /* end i1 */
    }/* End k1 */
    fprintf(fichtm,"</ul>");
    fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplot(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   /*   if((ficgp=fopen(optionfilegnuplot,"a"))==NULL) { */
   /*     printf("Problem with file %s",optionfilegnuplot); */
   /*     fprintf(ficlog,"Problem with file %s",optionfilegnuplot); */
   /*   } */
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
     m=pow(2,cptcoveff);
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
    /* 1eme*/
     for (cpt=1; cpt<= nlstate ; cpt ++) {
      for (k1=1; k1<= m ; k1 ++) {
        fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"v"),cpt,k1);
        fprintf(ficgp,"\n#set out \"v%s%d%d.png\" \n",optionfilefiname,cpt,k1);
        fprintf(ficgp,"set xlabel \"Age\" \n\
   set ylabel \"Probability\" \n\
   set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:2 \"\%%lf",ageminpar,fage,subdirf2(fileres,"vpl"),k1-1,k1-1);
   
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }
        fprintf(ficgp,"\" t\"Period (stable) prevalence\" w l 0,\"%s\" every :::%d::%d u 1:($2+1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1);
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        } 
        fprintf(ficgp,"\" t\"95\%% CI\" w l 1,\"%s\" every :::%d::%d u 1:($2-1.96*$3) \"\%%lf",subdirf2(fileres,"vpl"),k1-1,k1-1); 
        for (i=1; i<= nlstate ; i ++) {
          if (i==cpt) fprintf(ficgp," \%%lf (\%%lf)");
          else fprintf(ficgp," \%%*lf (\%%*lf)");
        }  
        fprintf(ficgp,"\" t\"\" w l 1,\"%s\" every :::%d::%d u 1:($%d) t\"Observed prevalence \" w l 2",subdirf2(fileres,"p"),k1-1,k1-1,2+4*(cpt-1));
      }
     }
     /*2 eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       fprintf(ficgp,"\nset out \"%s%d.png\" \n",subdirf2(optionfilefiname,"e"),k1);
       fprintf(ficgp,"set ylabel \"Years\" \nset ter png small\nset size 0.65,0.65\nplot [%.f:%.f] ",ageminpar,fage);
       
       for (i=1; i<= nlstate+1 ; i ++) {
         k=2*i;
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:2 \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== 1) fprintf(ficgp,"\" t\"TLE\" w l ,");
         else fprintf(ficgp,"\" t\"LE in state (%d)\" w l ,",i-1);
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2-$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         fprintf(ficgp,"\" t\"\" w l 0,");
         fprintf(ficgp,"\"%s\" every :::%d::%d u 1:($2+$3*2) \"\%%lf",subdirf2(fileres,"t"),k1-1,k1-1);
         for (j=1; j<= nlstate+1 ; j ++) {
           if (j==i) fprintf(ficgp," \%%lf (\%%lf)");
           else fprintf(ficgp," \%%*lf (\%%*lf)");
         }   
         if (i== (nlstate+1)) fprintf(ficgp,"\" t\"\" w l 0");
         else fprintf(ficgp,"\" t\"\" w l 0,");
       }
     }
     
     /*3eme*/
     
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<= nlstate ; cpt ++) {
         /*       k=2+nlstate*(2*cpt-2); */
         k=2+(nlstate+1)*(cpt-1);
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"exp"),cpt,k1);
         fprintf(ficgp,"set ter png small\n\
   set size 0.65,0.65\n\
   plot [%.f:%.f] \"%s\" every :::%d::%d u 1:%d t \"e%d1\" w l",ageminpar,fage,subdirf2(fileres,"e"),k1-1,k1-1,k,cpt);
         /*fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d-2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           fprintf(ficgp,",\"e%s\" every :::%d::%d u 1:($%d+2*$%d) \"\%%lf ",fileres,k1-1,k1-1,k,k+1);
           for (i=1; i<= nlstate*2 ; i ++) fprintf(ficgp,"\%%lf (\%%lf) ");
           fprintf(ficgp,"\" t \"e%d1\" w l",cpt);
           
         */
         for (i=1; i< nlstate ; i ++) {
           fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+i,cpt,i+1);
           /*      fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d%d\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+2*i,cpt,i+1);*/
           
         } 
         fprintf(ficgp," ,\"%s\" every :::%d::%d u 1:%d t \"e%d.\" w l",subdirf2(fileres,"e"),k1-1,k1-1,k+nlstate,cpt);
       }
     }
     
     /* CV preval stable (period) */
     for (k1=1; k1<= m ; k1 ++) { 
       for (cpt=1; cpt<=nlstate ; cpt ++) {
         k=3;
         fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"p"),cpt,k1);
         fprintf(ficgp,"set xlabel \"Age\" \nset ylabel \"Probability\" \n\
   set ter png small\nset size 0.65,0.65\n\
   unset log y\n\
   plot [%.f:%.f] \"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",ageminpar,agemaxpar,subdirf2(fileres,"pij"),k1,k+cpt+1,k+1);
         
         for (i=1; i< nlstate ; i ++)
           fprintf(ficgp,"+$%d",k+i+1);
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l",cpt,cpt+1);
         
         l=3+(nlstate+ndeath)*cpt;
         fprintf(ficgp,",\"%s\" u ($1==%d ? ($3):1/0):($%d/($%d",subdirf2(fileres,"pij"),k1,l+cpt+1,l+1);
         for (i=1; i< nlstate ; i ++) {
           l=3+(nlstate+ndeath)*cpt;
           fprintf(ficgp,"+$%d",l+i+1);
         }
         fprintf(ficgp,")) t\"prev(%d,%d)\" w l\n",cpt+1,cpt+1);   
       } 
     }  
     
     /* proba elementaires */
     for(i=1,jk=1; i <=nlstate; i++){
       for(k=1; k <=(nlstate+ndeath); k++){
         if (k != i) {
           for(j=1; j <=ncovmodel; j++){
             fprintf(ficgp,"p%d=%f ",jk,p[jk]);
             jk++; 
             fprintf(ficgp,"\n");
           }
         }
       }
      }
   
      for(ng=1; ng<=2;ng++){ /* Number of graphics: first is probabilities second is incidence per year*/
        for(jk=1; jk <=m; jk++) {
          fprintf(ficgp,"\nset out \"%s%d%d.png\" \n",subdirf2(optionfilefiname,"pe"),jk,ng); 
          if (ng==2)
            fprintf(ficgp,"\nset ylabel \"Quasi-incidence per year\"\n");
          else
            fprintf(ficgp,"\nset title \"Probability\"\n");
          fprintf(ficgp,"\nset ter png small\nset size 0.65,0.65\nset log y\nplot  [%.f:%.f] ",ageminpar,agemaxpar);
          i=1;
          for(k2=1; k2<=nlstate; k2++) {
            k3=i;
            for(k=1; k<=(nlstate+ndeath); k++) {
              if (k != k2){
                if(ng==2)
                  fprintf(ficgp," %f*exp(p%d+p%d*x",YEARM/stepm,i,i+1);
                else
                  fprintf(ficgp," exp(p%d+p%d*x",i,i+1);
                ij=1;
                for(j=3; j <=ncovmodel; j++) {
                  if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                    fprintf(ficgp,"+p%d*%d*x",i+j-1,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                    ij++;
                  }
                  else
                    fprintf(ficgp,"+p%d*%d",i+j-1,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                }
                fprintf(ficgp,")/(1");
                
                for(k1=1; k1 <=nlstate; k1++){   
                  fprintf(ficgp,"+exp(p%d+p%d*x",k3+(k1-1)*ncovmodel,k3+(k1-1)*ncovmodel+1);
                  ij=1;
                  for(j=3; j <=ncovmodel; j++){
                    if(((j-2)==Tage[ij]) &&(ij <=cptcovage)) {
                      fprintf(ficgp,"+p%d*%d*x",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][Tvar[j-2]]]);
                      ij++;
                    }
                    else
                      fprintf(ficgp,"+p%d*%d",k3+(k1-1)*ncovmodel+1+j-2,nbcode[Tvar[j-2]][codtab[jk][j-2]]);
                  }
                  fprintf(ficgp,")");
                }
                fprintf(ficgp,") t \"p%d%d\" ", k2,k);
                if ((k+k2)!= (nlstate*2+ndeath)) fprintf(ficgp,",");
                i=i+ncovmodel;
              }
            } /* end k */
          } /* end k2 */
        } /* end jk */
      } /* end ng */
      fflush(ficgp); 
   }  /* end gnuplot */
   
   
   /*************** Moving average **************/
   int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav){
   
     int i, cpt, cptcod;
     int modcovmax =1;
     int mobilavrange, mob;
     double age;
   
     modcovmax=2*cptcoveff;/* Max number of modalities. We suppose 
                              a covariate has 2 modalities */
     if (cptcovn<1) modcovmax=1; /* At least 1 pass */
   
     if(mobilav==1||mobilav ==3 ||mobilav==5 ||mobilav== 7){
       if(mobilav==1) mobilavrange=5; /* default */
       else mobilavrange=mobilav;
       for (age=bage; age<=fage; age++)
         for (i=1; i<=nlstate;i++)
           for (cptcod=1;cptcod<=modcovmax;cptcod++)
             mobaverage[(int)age][i][cptcod]=probs[(int)age][i][cptcod];
       /* We keep the original values on the extreme ages bage, fage and for 
          fage+1 and bage-1 we use a 3 terms moving average; for fage+2 bage+2
          we use a 5 terms etc. until the borders are no more concerned. 
       */ 
       for (mob=3;mob <=mobilavrange;mob=mob+2){
         for (age=bage+(mob-1)/2; age<=fage-(mob-1)/2; age++){
           for (i=1; i<=nlstate;i++){
             for (cptcod=1;cptcod<=modcovmax;cptcod++){
               mobaverage[(int)age][i][cptcod] =probs[(int)age][i][cptcod];
                 for (cpt=1;cpt<=(mob-1)/2;cpt++){
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age-cpt][i][cptcod];
                   mobaverage[(int)age][i][cptcod] +=probs[(int)age+cpt][i][cptcod];
                 }
               mobaverage[(int)age][i][cptcod]=mobaverage[(int)age][i][cptcod]/mob;
             }
           }
         }/* end age */
       }/* end mob */
     }else return -1;
     return 0;
   }/* End movingaverage */
   
   
   /************** Forecasting ******************/
   prevforecast(char fileres[], double anproj1, double mproj1, double jproj1, double ageminpar, double agemax, double dateprev1, double dateprev2, int mobilav, double bage, double fage, int firstpass, int lastpass, double anproj2, double p[], int cptcoveff){
     /* proj1, year, month, day of starting projection 
        agemin, agemax range of age
        dateprev1 dateprev2 range of dates during which prevalence is computed
        anproj2 year of en of projection (same day and month as proj1).
     */
     int yearp, stepsize, hstepm, nhstepm, j, k, c, cptcod, i, h, i1;
     int *popage;
     double agec; /* generic age */
     double agelim, ppij, yp,yp1,yp2,jprojmean,mprojmean,anprojmean;
     double *popeffectif,*popcount;
     double ***p3mat;
     double ***mobaverage;
     char fileresf[FILENAMELENGTH];
   
     agelim=AGESUP;
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
    
     strcpy(fileresf,"f"); 
     strcat(fileresf,fileres);
     if((ficresf=fopen(fileresf,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", fileresf);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", fileresf);
     }
     printf("Computing forecasting: result on file '%s' \n", fileresf);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", fileresf);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     if(estepm < stepm){
       printf ("Problem %d lower than %d\n",estepm, stepm);
     }
     else  hstepm=estepm;   
   
     hstepm=hstepm/stepm; 
     yp1=modf(dateintmean,&yp);/* extracts integral of datemean in yp  and
                                  fractional in yp1 */
     anprojmean=yp;
     yp2=modf((yp1*12),&yp);
     mprojmean=yp;
     yp1=modf((yp2*30.5),&yp);
     jprojmean=yp;
     if(jprojmean==0) jprojmean=1;
     if(mprojmean==0) jprojmean=1;
   
     i1=cptcoveff;
     if (cptcovn < 1){i1=1;}
     
     fprintf(ficresf,"# Mean day of interviews %.lf/%.lf/%.lf (%.2f) between %.2f and %.2f \n",jprojmean,mprojmean,anprojmean,dateintmean,dateprev1,dateprev2); 
     
     fprintf(ficresf,"#****** Routine prevforecast **\n");
   
   /*            if (h==(int)(YEARM*yearp)){ */
     for(cptcov=1, k=0;cptcov<=i1;cptcov++){
       for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficresf,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficresf," V%d=%d, hpijx=probability over h years, hp.jx is weighted by observed prev ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficresf,"******\n");
         fprintf(ficresf,"# Covariate valuofcovar yearproj age");
         for(j=1; j<=nlstate+ndeath;j++){ 
           for(i=1; i<=nlstate;i++)              
             fprintf(ficresf," p%d%d",i,j);
           fprintf(ficresf," p.%d",j);
         }
         for (yearp=0; yearp<=(anproj2-anproj1);yearp +=stepsize) { 
           fprintf(ficresf,"\n");
           fprintf(ficresf,"\n# Forecasting at date %.lf/%.lf/%.lf ",jproj1,mproj1,anproj1+yearp);   
   
           for (agec=fage; agec>=(ageminpar-1); agec--){ 
             nhstepm=(int) rint((agelim-agec)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agec,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h*hstepm/YEARM*stepm ==yearp) {
                 fprintf(ficresf,"\n");
                 for(j=1;j<=cptcoveff;j++) 
                   fprintf(ficresf,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
                 fprintf(ficresf,"%.f %.f ",anproj1+yearp,agec+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 ppij=0.;
                 for(i=1; i<=nlstate;i++) {
                   if (mobilav==1) 
                     ppij=ppij+p3mat[i][j][h]*mobaverage[(int)agec][i][cptcod];
                   else {
                     ppij=ppij+p3mat[i][j][h]*probs[(int)(agec)][i][cptcod];
                   }
                   if (h*hstepm/YEARM*stepm== yearp) {
                     fprintf(ficresf," %.3f", p3mat[i][j][h]);
                   }
                 } /* end i */
                 if (h*hstepm/YEARM*stepm==yearp) {
                   fprintf(ficresf," %.3f", ppij);
                 }
               }/* end j */
             } /* end h */
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           } /* end agec */
         } /* end yearp */
       } /* end cptcod */
     } /* end  cptcov */
          
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     fclose(ficresf);
   }
   
   /************** Forecasting *****not tested NB*************/
   populforecast(char fileres[], double anpyram,double mpyram,double jpyram,double ageminpar, double agemax,double dateprev1, double dateprev2, int mobilav, double agedeb, double fage, int popforecast, char popfile[], double anpyram1,double p[], int i2){
     
     int cpt, stepsize, hstepm, nhstepm, j,k,c, cptcod, i,h;
     int *popage;
     double calagedatem, agelim, kk1, kk2;
     double *popeffectif,*popcount;
     double ***p3mat,***tabpop,***tabpopprev;
     double ***mobaverage;
     char filerespop[FILENAMELENGTH];
   
     tabpop= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     tabpopprev= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     agelim=AGESUP;
     calagedatem=(anpyram+mpyram/12.+jpyram/365.-dateintmean)*YEARM;
     
     prevalence(probs, ageminpar, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
     
     
     strcpy(filerespop,"pop"); 
     strcat(filerespop,fileres);
     if((ficrespop=fopen(filerespop,"w"))==NULL) {
       printf("Problem with forecast resultfile: %s\n", filerespop);
       fprintf(ficlog,"Problem with forecast resultfile: %s\n", filerespop);
     }
     printf("Computing forecasting: result on file '%s' \n", filerespop);
     fprintf(ficlog,"Computing forecasting: result on file '%s' \n", filerespop);
   
     if (cptcoveff==0) ncodemax[cptcoveff]=1;
   
     if (mobilav!=0) {
       mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       if (movingaverage(probs, ageminpar, fage, mobaverage,mobilav)!=0){
         fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
         printf(" Error in movingaverage mobilav=%d\n",mobilav);
       }
     }
   
     stepsize=(int) (stepm+YEARM-1)/YEARM;
     if (stepm<=12) stepsize=1;
     
     agelim=AGESUP;
     
     hstepm=1;
     hstepm=hstepm/stepm; 
     
     if (popforecast==1) {
       if((ficpop=fopen(popfile,"r"))==NULL) {
         printf("Problem with population file : %s\n",popfile);exit(0);
         fprintf(ficlog,"Problem with population file : %s\n",popfile);exit(0);
       } 
       popage=ivector(0,AGESUP);
       popeffectif=vector(0,AGESUP);
       popcount=vector(0,AGESUP);
       
       i=1;   
       while ((c=fscanf(ficpop,"%d %lf\n",&popage[i],&popcount[i])) != EOF) i=i+1;
      
       imx=i;
       for (i=1; i<imx;i++) popeffectif[popage[i]]=popcount[i];
     }
   
     for(cptcov=1,k=0;cptcov<=i2;cptcov++){
      for(cptcod=1;cptcod<=ncodemax[cptcoveff];cptcod++){
         k=k+1;
         fprintf(ficrespop,"\n#******");
         for(j=1;j<=cptcoveff;j++) {
           fprintf(ficrespop," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
         }
         fprintf(ficrespop,"******\n");
         fprintf(ficrespop,"# Age");
         for(j=1; j<=nlstate+ndeath;j++) fprintf(ficrespop," P.%d",j);
         if (popforecast==1)  fprintf(ficrespop," [Population]");
         
         for (cpt=0; cpt<=0;cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
           
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficrespop,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   if (mobilav==1) 
                     kk1=kk1+p3mat[i][j][h]*mobaverage[(int)agedeb+1][i][cptcod];
                   else {
                     kk1=kk1+p3mat[i][j][h]*probs[(int)(agedeb+1)][i][cptcod];
                   }
                 }
                 if (h==(int)(calagedatem+12*cpt)){
                   tabpop[(int)(agedeb)][j][cptcod]=kk1;
                     /*fprintf(ficrespop," %.3f", kk1);
                       if (popforecast==1) fprintf(ficrespop," [%.f]", kk1*popeffectif[(int)agedeb+1]);*/
                 }
               }
               for(i=1; i<=nlstate;i++){
                 kk1=0.;
                   for(j=1; j<=nlstate;j++){
                     kk1= kk1+tabpop[(int)(agedeb)][j][cptcod]; 
                   }
                     tabpopprev[(int)(agedeb)][i][cptcod]=tabpop[(int)(agedeb)][i][cptcod]/kk1*popeffectif[(int)(agedeb+(calagedatem+12*cpt)*hstepm/YEARM*stepm-1)];
               }
   
               if (h==(int)(calagedatem+12*cpt)) for(j=1; j<=nlstate;j++) 
                 fprintf(ficrespop," %15.2f",tabpopprev[(int)(agedeb+1)][j][cptcod]);
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
    
     /******/
   
         for (cpt=1; cpt<=(anpyram1-anpyram);cpt++) { 
           fprintf(ficrespop,"\n\n# Forecasting at date %.lf/%.lf/%.lf ",jpyram,mpyram,anpyram+cpt);   
           for (agedeb=(fage-((int)calagedatem %12/12.)); agedeb>=(ageminpar-((int)calagedatem %12)/12.); agedeb--){ 
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); 
             nhstepm = nhstepm/hstepm; 
             
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             for (h=0; h<=nhstepm; h++){
               if (h==(int) (calagedatem+YEARM*cpt)) {
                 fprintf(ficresf,"\n %3.f ",agedeb+h*hstepm/YEARM*stepm);
               } 
               for(j=1; j<=nlstate+ndeath;j++) {
                 kk1=0.;kk2=0;
                 for(i=1; i<=nlstate;i++) {              
                   kk1=kk1+p3mat[i][j][h]*tabpopprev[(int)agedeb+1][i][cptcod];    
                 }
                 if (h==(int)(calagedatem+12*cpt)) fprintf(ficresf," %15.2f", kk1);        
               }
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
           }
         }
      } 
     }
    
     if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     if (popforecast==1) {
       free_ivector(popage,0,AGESUP);
       free_vector(popeffectif,0,AGESUP);
       free_vector(popcount,0,AGESUP);
     }
     free_ma3x(tabpop,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     free_ma3x(tabpopprev,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
     fclose(ficrespop);
   } /* End of popforecast */
   
   int fileappend(FILE *fichier, char *optionfich)
   {
     if((fichier=fopen(optionfich,"a"))==NULL) {
       printf("Problem with file: %s\n", optionfich);
       fprintf(ficlog,"Problem with file: %s\n", optionfich);
       return (0);
     }
     fflush(fichier);
     return (1);
   }
   
   
   /**************** function prwizard **********************/
   void prwizard(int ncovmodel, int nlstate, int ndeath,  char model[], FILE *ficparo)
   {
   
     /* Wizard to print covariance matrix template */
   
     char ca[32], cb[32], cc[32];
     int i,j, k, l, li, lj, lk, ll, jj, npar, itimes;
     int numlinepar;
   
     printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     fprintf(ficparo,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         /*ca[0]= k+'a'-1;ca[1]='\0';*/
         printf("%1d%1d",i,j);
         fprintf(ficparo,"%1d%1d",i,j);
         for(k=1; k<=ncovmodel;k++){
           /*        printf(" %lf",param[i][j][k]); */
           /*        fprintf(ficparo," %lf",param[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Scales (for hessian or gradient estimation)\n");
     fprintf(ficparo,"# Scales (for hessian or gradient estimation)\n");
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/ 
     for(i=1; i <=nlstate; i++){
       jj=0;
       for(j=1; j <=nlstate+ndeath; j++){
         if(j==i) continue;
         jj++;
         fprintf(ficparo,"%1d%1d",i,j);
         printf("%1d%1d",i,j);
         fflush(stdout);
         for(k=1; k<=ncovmodel;k++){
           /*      printf(" %le",delti3[i][j][k]); */
           /*      fprintf(ficparo," %le",delti3[i][j][k]); */
           printf(" 0.");
           fprintf(ficparo," 0.");
         }
         numlinepar++;
         printf("\n");
         fprintf(ficparo,"\n");
       }
     }
     printf("# Covariance matrix\n");
   /* # 121 Var(a12)\n\ */
   /* # 122 Cov(b12,a12) Var(b12)\n\ */
   /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
   /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
   /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
   /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
   /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
   /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
     fflush(stdout);
     fprintf(ficparo,"# Covariance matrix\n");
     /* # 121 Var(a12)\n\ */
     /* # 122 Cov(b12,a12) Var(b12)\n\ */
     /* #   ...\n\ */
     /* # 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n" */
     
     for(itimes=1;itimes<=2;itimes++){
       jj=0;
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if(j==i) continue;
           for(k=1; k<=ncovmodel;k++){
             jj++;
             ca[0]= k+'a'-1;ca[1]='\0';
             if(itimes==1){
               printf("#%1d%1d%d",i,j,k);
               fprintf(ficparo,"#%1d%1d%d",i,j,k);
             }else{
               printf("%1d%1d%d",i,j,k);
               fprintf(ficparo,"%1d%1d%d",i,j,k);
               /*  printf(" %.5le",matcov[i][j]); */
             }
             ll=0;
             for(li=1;li <=nlstate; li++){
               for(lj=1;lj <=nlstate+ndeath; lj++){
                 if(lj==li) continue;
                 for(lk=1;lk<=ncovmodel;lk++){
                   ll++;
                   if(ll<=jj){
                     cb[0]= lk +'a'-1;cb[1]='\0';
                     if(ll<jj){
                       if(itimes==1){
                         printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         fprintf(ficparo," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }else{
                       if(itimes==1){
                         printf(" Var(%s%1d%1d)",ca,i,j);
                         fprintf(ficparo," Var(%s%1d%1d)",ca,i,j);
                       }else{
                         printf(" 0.");
                         fprintf(ficparo," 0.");
                       }
                     }
                   }
                 } /* end lk */
               } /* end lj */
             } /* end li */
             printf("\n");
             fprintf(ficparo,"\n");
             numlinepar++;
           } /* end k*/
         } /*end j */
       } /* end i */
     } /* end itimes */
   
   } /* end of prwizard */
   /******************* Gompertz Likelihood ******************************/
   double gompertz(double x[])
   { 
     double A,B,L=0.0,sump=0.,num=0.;
     int i,n=0; /* n is the size of the sample */
   
     for (i=0;i<=imx-1 ; i++) {
       sump=sump+weight[i];
       /*    sump=sump+1;*/
       num=num+1;
     }
    
    
     /* for (i=0; i<=imx; i++) 
        if (wav[i]>0) printf("i=%d ageex=%lf agecens=%lf agedc=%lf cens=%d %d\n" ,i,ageexmed[i],agecens[i],agedc[i],cens[i],wav[i]);*/
   
     for (i=1;i<=imx ; i++)
       {
         if (cens[i] == 1 && wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agecens[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)));
         
         if (cens[i] == 0 && wav[i]>1)
           A=-x[1]/(x[2])*(exp(x[2]*(agedc[i]-agegomp))-exp(x[2]*(ageexmed[i]-agegomp)))
                +log(x[1]/YEARM)+x[2]*(agedc[i]-agegomp)+log(YEARM);  
         
         /*if (wav[i] > 1 && agecens[i] > 15) {*/ /* ??? */
         if (wav[i] > 1 ) { /* ??? */
           L=L+A*weight[i];
           /*      printf("\ni=%d A=%f L=%lf x[1]=%lf x[2]=%lf ageex=%lf agecens=%lf cens=%d agedc=%lf weight=%lf\n",i,A,L,x[1],x[2],ageexmed[i]*12,agecens[i]*12,cens[i],agedc[i]*12,weight[i]);*/
         }
       }
   
    /*printf("x1=%2.9f x2=%2.9f x3=%2.9f L=%f\n",x[1],x[2],x[3],L);*/
    
     return -2*L*num/sump;
   }
   
   /******************* Printing html file ***********/
   void printinghtmlmort(char fileres[], char title[], char datafile[], int firstpass, \
                     int lastpass, int stepm, int weightopt, char model[],\
                     int imx,  double p[],double **matcov,double agemortsup){
     int i,k;
   
     fprintf(fichtm,"<ul><li><h4>Result files </h4>\n Force of mortality. Parameters of the Gompertz fit (with confidence interval in brackets):<br>");
     fprintf(fichtm,"  mu(age) =%lf*exp(%lf*(age-%d)) per year<br><br>",p[1],p[2],agegomp);
     for (i=1;i<=2;i++) 
       fprintf(fichtm," p[%d] = %lf [%f ; %f]<br>\n",i,p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
     fprintf(fichtm,"<br><br><img src=\"graphmort.png\">");
     fprintf(fichtm,"</ul>");
   
   fprintf(fichtm,"<ul><li><h4>Life table</h4>\n <br>");
   
    fprintf(fichtm,"\nAge   l<inf>x</inf>     q<inf>x</inf> d(x,x+1)    L<inf>x</inf>     T<inf>x</inf>     e<infx</inf><br>");
   
    for (k=agegomp;k<(agemortsup-2);k++) 
      fprintf(fichtm,"%d %.0lf %lf %.0lf %.0lf %.0lf %lf<br>\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
   
    
     fflush(fichtm);
   }
   
   /******************* Gnuplot file **************/
   void printinggnuplotmort(char fileres[], char optionfilefiname[], double ageminpar, double agemaxpar, double fage , char pathc[], double p[]){
   
     char dirfileres[132],optfileres[132];
     int m,cpt,k1,i,k,j,jk,k2,k3,ij,l;
     int ng;
   
   
     /*#ifdef windows */
     fprintf(ficgp,"cd \"%s\" \n",pathc);
       /*#endif */
   
   
     strcpy(dirfileres,optionfilefiname);
     strcpy(optfileres,"vpl");
     fprintf(ficgp,"set out \"graphmort.png\"\n "); 
     fprintf(ficgp,"set xlabel \"Age\"\n set ylabel \"Force of mortality (per year)\" \n "); 
     fprintf(ficgp, "set ter png small\n set log y\n"); 
     fprintf(ficgp, "set size 0.65,0.65\n");
     fprintf(ficgp,"plot [%d:100] %lf*exp(%lf*(x-%d))",agegomp,p[1],p[2],agegomp);
   
   } 
   
   
   
   
   
   /***********************************************/
   /**************** Main Program *****************/
   /***********************************************/
   
   int main(int argc, char *argv[])
   {
     int movingaverage(double ***probs, double bage,double fage, double ***mobaverage, int mobilav);
     int i,j, k, n=MAXN,iter,m,size=100,cptcode, cptcod;
     int linei, month, year,iout;
     int jj, ll, li, lj, lk, imk;
     int numlinepar=0; /* Current linenumber of parameter file */
     int itimes;
     int NDIM=2;
   
     char ca[32], cb[32], cc[32];
     char dummy[]="                         ";
     /*  FILE *fichtm; *//* Html File */
     /* FILE *ficgp;*/ /*Gnuplot File */
     struct stat info;
     double agedeb, agefin,hf;
     double ageminpar=1.e20,agemin=1.e20, agemaxpar=-1.e20, agemax=-1.e20;
   
     double fret;
     double **xi,tmp,delta;
   
     double dum; /* Dummy variable */
     double ***p3mat;
     double ***mobaverage;
     int *indx;
     char line[MAXLINE], linepar[MAXLINE];
     char path[MAXLINE],pathc[MAXLINE],pathcd[MAXLINE],pathtot[MAXLINE],model[MAXLINE];
     char pathr[MAXLINE], pathimach[MAXLINE]; 
     char **bp, *tok, *val; /* pathtot */
     int firstobs=1, lastobs=10;
     int sdeb, sfin; /* Status at beginning and end */
     int c,  h , cpt,l;
     int ju,jl, mi;
     int i1,j1, k1,k2,k3,jk,aa,bb, stepsize, ij;
     int jnais,jdc,jint4,jint1,jint2,jint3,**outcome,*tab; 
     int mobilavproj=0 , prevfcast=0 ; /* moving average of prev, If prevfcast=1 prevalence projection */
     int mobilav=0,popforecast=0;
     int hstepm, nhstepm;
     int agemortsup;
     float  sumlpop=0.;
     double jprev1=1, mprev1=1,anprev1=2000,jprev2=1, mprev2=1,anprev2=2000;
     double jpyram=1, mpyram=1,anpyram=2000,jpyram1=1, mpyram1=1,anpyram1=2000;
   
     double bage, fage, age, agelim, agebase;
     double ftolpl=FTOL;
     double **prlim;
     double *severity;
     double ***param; /* Matrix of parameters */
     double  *p;
     double **matcov; /* Matrix of covariance */
     double ***delti3; /* Scale */
     double *delti; /* Scale */
     double ***eij, ***vareij;
     double **varpl; /* Variances of prevalence limits by age */
     double *epj, vepp;
     double kk1, kk2;
     double dateprev1, dateprev2,jproj1=1,mproj1=1,anproj1=2000,jproj2=1,mproj2=1,anproj2=2000;
     double **ximort;
     char *alph[]={"a","a","b","c","d","e"}, str[4];
     int *dcwave;
   
     char z[1]="c", occ;
   
     char stra[80], strb[80], strc[80], strd[80],stre[80],modelsav[80];
     char  *strt, strtend[80];
     char *stratrunc;
     int lstra;
   
     long total_usecs;
    
   /*   setlocale (LC_ALL, ""); */
   /*   bindtextdomain (PACKAGE, LOCALEDIR); */
   /*   textdomain (PACKAGE); */
   /*   setlocale (LC_CTYPE, ""); */
   /*   setlocale (LC_MESSAGES, ""); */
   
     /*   gettimeofday(&start_time, (struct timezone*)0); */ /* at first time */
     (void) gettimeofday(&start_time,&tzp);
     curr_time=start_time;
     tm = *localtime(&start_time.tv_sec);
     tmg = *gmtime(&start_time.tv_sec);
     strcpy(strstart,asctime(&tm));
   
   /*  printf("Localtime (at start)=%s",strstart); */
   /*  tp.tv_sec = tp.tv_sec +86400; */
   /*  tm = *localtime(&start_time.tv_sec); */
   /*   tmg.tm_year=tmg.tm_year +dsign*dyear; */
   /*   tmg.tm_mon=tmg.tm_mon +dsign*dmonth; */
   /*   tmg.tm_hour=tmg.tm_hour + 1; */
   /*   tp.tv_sec = mktime(&tmg); */
   /*   strt=asctime(&tmg); */
   /*   printf("Time(after) =%s",strstart);  */
   /*  (void) time (&time_value);
   *  printf("time=%d,t-=%d\n",time_value,time_value-86400);
   *  tm = *localtime(&time_value);
   *  strstart=asctime(&tm);
   *  printf("tim_value=%d,asctime=%s\n",time_value,strstart); 
   */
   
     nberr=0; /* Number of errors and warnings */
     nbwarn=0;
     getcwd(pathcd, size);
   
     printf("\n%s\n%s",version,fullversion);
     if(argc <=1){
       printf("\nEnter the parameter file name: ");
       fgets(pathr,FILENAMELENGTH,stdin);
       i=strlen(pathr);
       if(pathr[i-1]=='\n')
         pathr[i-1]='\0';
      for (tok = pathr; tok != NULL; ){
         printf("Pathr |%s|\n",pathr);
         while ((val = strsep(&tok, "\"" )) != NULL && *val == '\0');
         printf("val= |%s| pathr=%s\n",val,pathr);
         strcpy (pathtot, val);
         if(pathr[0] == '\0') break; /* Un peu sale */
       }
     }
     else{
       strcpy(pathtot,argv[1]);
     }
     /*if(getcwd(pathcd, MAXLINE)!= NULL)printf ("Error pathcd\n");*/
     /*cygwin_split_path(pathtot,path,optionfile);
       printf("pathtot=%s, path=%s, optionfile=%s\n",pathtot,path,optionfile);*/
     /* cutv(path,optionfile,pathtot,'\\');*/
   
     /* Split argv[0], imach program to get pathimach */
     printf("\nargv[0]=%s argv[1]=%s, \n",argv[0],argv[1]);
     split(argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
     printf("\nargv[0]=%s pathimach=%s, \noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",argv[0],pathimach,optionfile,optionfilext,optionfilefiname);
    /*   strcpy(pathimach,argv[0]); */
     /* Split argv[1]=pathtot, parameter file name to get path, optionfile, extension and name */
     split(pathtot,path,optionfile,optionfilext,optionfilefiname);
     printf("\npathtot=%s,\npath=%s,\noptionfile=%s \noptionfilext=%s \noptionfilefiname=%s\n",pathtot,path,optionfile,optionfilext,optionfilefiname);
     chdir(path);
     strcpy(command,"mkdir ");
     strcat(command,optionfilefiname);
     if((outcmd=system(command)) != 0){
       printf("Problem creating directory or it already exists %s%s, err=%d\n",path,optionfilefiname,outcmd);
       /* fprintf(ficlog,"Problem creating directory %s%s\n",path,optionfilefiname); */
       /* fclose(ficlog); */
   /*     exit(1); */
     }
   /*   if((imk=mkdir(optionfilefiname))<0){ */
   /*     perror("mkdir"); */
   /*   } */
   
     /*-------- arguments in the command line --------*/
   
     /* Log file */
     strcat(filelog, optionfilefiname);
     strcat(filelog,".log");    /* */
     if((ficlog=fopen(filelog,"w"))==NULL)    {
       printf("Problem with logfile %s\n",filelog);
       goto end;
     }
     fprintf(ficlog,"Log filename:%s\n",filelog);
     fprintf(ficlog,"\n%s\n%s",version,fullversion);
     fprintf(ficlog,"\nEnter the parameter file name: \n");
     fprintf(ficlog,"pathimach=%s\npathtot=%s\n\
    path=%s \n\
    optionfile=%s\n\
    optionfilext=%s\n\
    optionfilefiname=%s\n",pathimach,pathtot,path,optionfile,optionfilext,optionfilefiname);
   
     printf("Local time (at start):%s",strstart);
     fprintf(ficlog,"Local time (at start): %s",strstart);
     fflush(ficlog);
   /*   (void) gettimeofday(&curr_time,&tzp); */
   /*   printf("Elapsed time %d\n", asc_diff_time(curr_time.tv_sec-start_time.tv_sec,tmpout)); */
   
     /* */
     strcpy(fileres,"r");
     strcat(fileres, optionfilefiname);
     strcat(fileres,".txt");    /* Other files have txt extension */
   
     /*---------arguments file --------*/
   
     if((ficpar=fopen(optionfile,"r"))==NULL)    {
       printf("Problem with optionfile %s\n",optionfile);
       fprintf(ficlog,"Problem with optionfile %s\n",optionfile);
       fflush(ficlog);
       goto end;
     }
   
   
   
     strcpy(filereso,"o");
     strcat(filereso,fileres);
     if((ficparo=fopen(filereso,"w"))==NULL) { /* opened on subdirectory */
       printf("Problem with Output resultfile: %s\n", filereso);
       fprintf(ficlog,"Problem with Output resultfile: %s\n", filereso);
       fflush(ficlog);
       goto end;
     }
   
     /* Reads comments: lines beginning with '#' */
     numlinepar=0;
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
     fscanf(ficpar,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%lf stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d model=%s\n",title, datafile, &lastobs, &firstpass,&lastpass,&ftol, &stepm, &ncovcol, &nlstate,&ndeath, &maxwav, &mle, &weightopt,model);
     numlinepar++;
     printf("title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate,ndeath, maxwav, mle, weightopt,model);
     fprintf(ficparo,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fprintf(ficlog,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle=%d weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol,stepm,ncovcol,nlstate,ndeath,maxwav, mle, weightopt,model);
     fflush(ficlog);
     while((c=getc(ficpar))=='#' && c!= EOF){
       ungetc(c,ficpar);
       fgets(line, MAXLINE, ficpar);
       numlinepar++;
       puts(line);
       fputs(line,ficparo);
       fputs(line,ficlog);
     }
     ungetc(c,ficpar);
   
      
     covar=matrix(0,NCOVMAX,1,n); 
     cptcovn=0; /*Number of covariates, i.e. number of '+' in model statement*/
     if (strlen(model)>1) cptcovn=nbocc(model,'+')+1;
   
     ncovmodel=2+cptcovn; /*Number of variables = cptcovn + intercept + age */
     nvar=ncovmodel-1; /* Suppressing age as a basic covariate */
     npar= (nlstate+ndeath-1)*nlstate*ncovmodel; /* Number of parameters*/
   
     delti3= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
     delti=delti3[1][1];
     /*delti=vector(1,npar); *//* Scale of each paramater (output from hesscov)*/
     if(mle==-1){ /* Print a wizard for help writing covariance matrix */
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-1, look at file %s for a template of covariance matrix \n",filereso);
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       fclose (ficparo);
       fclose (ficlog);
       exit(0);
     }
     else if(mle==-3) {
       prwizard(ncovmodel, nlstate, ndeath, model, ficparo);
       printf(" You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       fprintf(ficlog," You choose mle=-3, look at file %s for a template of covariance matrix \n",filereso);
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       matcov=matrix(1,npar,1,npar);
     }
     else{
       /* Read guess parameters */
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
       
       param= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel);
       for(i=1; i <=nlstate; i++){
         j=0;
         for(jj=1; jj <=nlstate+ndeath; jj++){
           if(jj==i) continue;
           j++;
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1 != i) && (j1 != j)){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           fprintf(ficparo,"%1d%1d",i1,j1);
           if(mle==1)
             printf("%1d%1d",i,j);
           fprintf(ficlog,"%1d%1d",i,j);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar," %lf",&param[i][j][k]);
             if(mle==1){
               printf(" %lf",param[i][j][k]);
               fprintf(ficlog," %lf",param[i][j][k]);
             }
             else
               fprintf(ficlog," %lf",param[i][j][k]);
             fprintf(ficparo," %lf",param[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           if(mle==1)
             printf("\n");
           fprintf(ficlog,"\n");
           fprintf(ficparo,"\n");
         }
       }  
       fflush(ficlog);
   
       p=param[1][1];
       
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
   
       for(i=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath-1; j++){
           fscanf(ficpar,"%1d%1d",&i1,&j1);
           if ((i1-i)*(j1-j)!=0){
             printf("Error in line parameters number %d, %1d%1d instead of %1d%1d \n",numlinepar, i,j, i1, j1);
             exit(1);
           }
           printf("%1d%1d",i,j);
           fprintf(ficparo,"%1d%1d",i1,j1);
           fprintf(ficlog,"%1d%1d",i1,j1);
           for(k=1; k<=ncovmodel;k++){
             fscanf(ficpar,"%le",&delti3[i][j][k]);
             printf(" %le",delti3[i][j][k]);
             fprintf(ficparo," %le",delti3[i][j][k]);
             fprintf(ficlog," %le",delti3[i][j][k]);
           }
           fscanf(ficpar,"\n");
           numlinepar++;
           printf("\n");
           fprintf(ficparo,"\n");
           fprintf(ficlog,"\n");
         }
       }
       fflush(ficlog);
   
       delti=delti3[1][1];
   
   
       /* free_ma3x(delti3,1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ /* Hasn't to to freed here otherwise delti is no more allocated */
     
       /* Reads comments: lines beginning with '#' */
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         numlinepar++;
         puts(line);
         fputs(line,ficparo);
         fputs(line,ficlog);
       }
       ungetc(c,ficpar);
     
       matcov=matrix(1,npar,1,npar);
       for(i=1; i <=npar; i++){
         fscanf(ficpar,"%s",&str);
         if(mle==1)
           printf("%s",str);
         fprintf(ficlog,"%s",str);
         fprintf(ficparo,"%s",str);
         for(j=1; j <=i; j++){
           fscanf(ficpar," %le",&matcov[i][j]);
           if(mle==1){
             printf(" %.5le",matcov[i][j]);
           }
           fprintf(ficlog," %.5le",matcov[i][j]);
           fprintf(ficparo," %.5le",matcov[i][j]);
         }
         fscanf(ficpar,"\n");
         numlinepar++;
         if(mle==1)
           printf("\n");
         fprintf(ficlog,"\n");
         fprintf(ficparo,"\n");
       }
       for(i=1; i <=npar; i++)
         for(j=i+1;j<=npar;j++)
           matcov[i][j]=matcov[j][i];
       
       if(mle==1)
         printf("\n");
       fprintf(ficlog,"\n");
       
       fflush(ficlog);
       
       /*-------- Rewriting parameter file ----------*/
       strcpy(rfileres,"r");    /* "Rparameterfile */
       strcat(rfileres,optionfilefiname);    /* Parameter file first name*/
       strcat(rfileres,".");    /* */
       strcat(rfileres,optionfilext);    /* Other files have txt extension */
       if((ficres =fopen(rfileres,"w"))==NULL) {
         printf("Problem writing new parameter file: %s\n", fileres);goto end;
         fprintf(ficlog,"Problem writing new parameter file: %s\n", fileres);goto end;
       }
       fprintf(ficres,"#%s\n",version);
     }    /* End of mle != -3 */
   
     /*-------- data file ----------*/
     if((fic=fopen(datafile,"r"))==NULL)    {
       printf("Problem while opening datafile: %s\n", datafile);goto end;
       fprintf(ficlog,"Problem while opening datafile: %s\n", datafile);goto end;
     }
   
     n= lastobs;
     severity = vector(1,maxwav);
     outcome=imatrix(1,maxwav+1,1,n);
     num=lvector(1,n);
     moisnais=vector(1,n);
     annais=vector(1,n);
     moisdc=vector(1,n);
     andc=vector(1,n);
     agedc=vector(1,n);
     cod=ivector(1,n);
     weight=vector(1,n);
     for(i=1;i<=n;i++) weight[i]=1.0; /* Equal weights, 1 by default */
     mint=matrix(1,maxwav,1,n);
     anint=matrix(1,maxwav,1,n);
     s=imatrix(1,maxwav+1,1,n);
     tab=ivector(1,NCOVMAX);
     ncodemax=ivector(1,8);
   
     i=1;
     linei=0;
     while ((fgets(line, MAXLINE, fic) != NULL) &&((i >= firstobs) && (i <=lastobs))) {
       linei=linei+1;
       for(j=strlen(line); j>=0;j--){  /* Untabifies line */
         if(line[j] == '\t')
           line[j] = ' ';
       }
       for(j=strlen(line)-1; (line[j]==' ')||(line[j]==10)||(line[j]==13);j--){
         ;
       };
       line[j+1]=0;  /* Trims blanks at end of line */
       if(line[0]=='#'){
         fprintf(ficlog,"Comment line\n%s\n",line);
         printf("Comment line\n%s\n",line);
         continue;
       }
   
       for (j=maxwav;j>=1;j--){
         cutv(stra, strb,line,' '); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         /*        if (errno == ERANGE && (lval == LONG_MAX || lval == LONG_MIN))*/
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %d %s for individual %d, '%s'\nShould be a status of wave %d. Setting maxwav=%d might be wrong.  Exiting.\n", strb, linei,i,line,j,maxwav);
           exit(1);
         }
         s[j][i]=lval;
         
         strcpy(line,stra);
         cutv(stra, strb,line,' ');
         if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
         }
         else  if(iout=sscanf(strb,"%s.") != 0){
           month=99;
           year=9999;
         }else{
           printf("Error reading data around '%s' at line number %ld %s for individual %d, '%s'\nShould be a date of interview (mm/yyyy or .) at wave %d.  Exiting.\n",strb, linei,i, line,j);
           exit(1);
         }
         anint[j][i]= (double) year; 
         mint[j][i]= (double)month; 
         strcpy(line,stra);
       } /* ENd Waves */
       
       cutv(stra, strb,line,' '); 
       if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
       }
       else  if(iout=sscanf(strb,"%s.",dummy) != 0){
         month=99;
         year=9999;
       }else{
         printf("Error reading data around '%s' at line number %ld %s for individual %d, '%s'\nShould be a date of death (mm/yyyy or .).  Exiting.\n",strb, linei,i,line);
         exit(1);
       }
       andc[i]=(double) year; 
       moisdc[i]=(double) month; 
       strcpy(line,stra);
       
       cutv(stra, strb,line,' '); 
       if(iout=sscanf(strb,"%d/%d",&month, &year) != 0){
       }
       else  if(iout=sscanf(strb,"%s.") != 0){
         month=99;
         year=9999;
       }else{
         printf("Error reading data around '%s' at line number %ld %s for individual %d, '%s'\nShould be a date of birth (mm/yyyy or .).  Exiting.\n",strb, linei,i,line,j);
         exit(1);
       }
       annais[i]=(double)(year);
       moisnais[i]=(double)(month); 
       strcpy(line,stra);
       
       cutv(stra, strb,line,' '); 
       errno=0;
       lval=strtol(strb,&endptr,10); 
       if( strb[0]=='\0' || (*endptr != '\0')){
         printf("Error reading data around '%d' at line number %ld %s for individual %d\nShould be a weight.  Exiting.\n",lval, i,line,linei);
         exit(1);
       }
       weight[i]=(double)(lval); 
       strcpy(line,stra);
       
       for (j=ncovcol;j>=1;j--){
         cutv(stra, strb,line,' '); 
         errno=0;
         lval=strtol(strb,&endptr,10); 
         if( strb[0]=='\0' || (*endptr != '\0')){
           printf("Error reading data around '%d' at line number %ld %s for individual %d, '%s'\nShould be a covar (meaning 0 for the reference or 1).  Exiting.\n",lval, linei,i, line);
           exit(1);
         }
         if(lval <-1 || lval >1){
           printf("Error reading data around '%d' at line number %ld %s for individual %d, '%s'\nShould be a value of the %d covar (meaning 0 for the reference or 1. IMaCh does not build design variables, do it your self).  Exiting.\n",lval,linei, i,line,j);
           exit(1);
         }
         covar[j][i]=(double)(lval);
         strcpy(line,stra);
       } 
       lstra=strlen(stra);
       
       if(lstra > 9){ /* More than 2**32 or max of what printf can write with %ld */
         stratrunc = &(stra[lstra-9]);
         num[i]=atol(stratrunc);
       }
       else
         num[i]=atol(stra);
       /*if((s[2][i]==2) && (s[3][i]==-1)&&(s[4][i]==9)){
         printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]),weight[i], (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i])); ij=ij+1;}*/
       
       i=i+1;
     } /* End loop reading  data */
     fclose(fic);
     /* printf("ii=%d", ij);
        scanf("%d",i);*/
     imx=i-1; /* Number of individuals */
   
     /* for (i=1; i<=imx; i++){
       if ((s[1][i]==3) && (s[2][i]==2)) s[2][i]=3;
       if ((s[2][i]==3) && (s[3][i]==2)) s[3][i]=3;
       if ((s[3][i]==3) && (s[4][i]==2)) s[4][i]=3;
       }*/
      /*  for (i=1; i<=imx; i++){
        if (s[4][i]==9)  s[4][i]=-1; 
        printf("%ld %.lf %.lf %.lf %.lf/%.lf %.lf/%.lf %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d %.lf/%.lf %d\n",num[i],(covar[1][i]), (covar[2][i]), (weight[i]), (moisnais[i]), (annais[i]), (moisdc[i]), (andc[i]), (mint[1][i]), (anint[1][i]), (s[1][i]),  (mint[2][i]), (anint[2][i]), (s[2][i]),  (mint[3][i]), (anint[3][i]), (s[3][i]),  (mint[4][i]), (anint[4][i]), (s[4][i]));}*/
     
     /* for (i=1; i<=imx; i++) */
    
      /*if ((s[3][i]==3) ||  (s[4][i]==3)) weight[i]=0.08;
        else weight[i]=1;*/
   
     /* Calculation of the number of parameters from char model */
     Tvar=ivector(1,15); /* stores the number n of the covariates in Vm+Vn at 1 and m at 2 */
     Tprod=ivector(1,15); 
     Tvaraff=ivector(1,15); 
     Tvard=imatrix(1,15,1,2);
     Tage=ivector(1,15);      
      
     if (strlen(model) >1){ /* If there is at least 1 covariate */
       j=0, j1=0, k1=1, k2=1;
       j=nbocc(model,'+'); /* j=Number of '+' */
       j1=nbocc(model,'*'); /* j1=Number of '*' */
       cptcovn=j+1; 
       cptcovprod=j1; /*Number of products */
       
       strcpy(modelsav,model); 
       if ((strcmp(model,"age")==0) || (strcmp(model,"age*age")==0)){
         printf("Error. Non available option model=%s ",model);
         fprintf(ficlog,"Error. Non available option model=%s ",model);
         goto end;
       }
       
       /* This loop fills the array Tvar from the string 'model'.*/
   
       for(i=(j+1); i>=1;i--){
         cutv(stra,strb,modelsav,'+'); /* keeps in strb after the last + */ 
         if (nbocc(modelsav,'+')==0) strcpy(strb,modelsav); /* and analyzes it */
         /*      printf("i=%d a=%s b=%s sav=%s\n",i, stra,strb,modelsav);*/
         /*scanf("%d",i);*/
         if (strchr(strb,'*')) {  /* Model includes a product */
           cutv(strd,strc,strb,'*'); /* strd*strc  Vm*Vn (if not *age)*/
           if (strcmp(strc,"age")==0) { /* Vn*age */
             cptcovprod--;
             cutv(strb,stre,strd,'V');
             Tvar[i]=atoi(stre); /* computes n in Vn and stores in Tvar*/
             cptcovage++;
               Tage[cptcovage]=i;
               /*printf("stre=%s ", stre);*/
           }
           else if (strcmp(strd,"age")==0) { /* or age*Vn */
             cptcovprod--;
             cutv(strb,stre,strc,'V');
             Tvar[i]=atoi(stre);
             cptcovage++;
             Tage[cptcovage]=i;
           }
           else {  /* Age is not in the model */
             cutv(strb,stre,strc,'V'); /* strc= Vn, stre is n*/
             Tvar[i]=ncovcol+k1;
             cutv(strb,strc,strd,'V'); /* strd was Vm, strc is m */
             Tprod[k1]=i;
             Tvard[k1][1]=atoi(strc); /* m*/
             Tvard[k1][2]=atoi(stre); /* n */
             Tvar[cptcovn+k2]=Tvard[k1][1];
             Tvar[cptcovn+k2+1]=Tvard[k1][2]; 
             for (k=1; k<=lastobs;k++) 
               covar[ncovcol+k1][k]=covar[atoi(stre)][k]*covar[atoi(strc)][k];
             k1++;
             k2=k2+2;
           }
         }
         else { /* no more sum */
           /*printf("d=%s c=%s b=%s\n", strd,strc,strb);*/
          /*  scanf("%d",i);*/
         cutv(strd,strc,strb,'V');
         Tvar[i]=atoi(strc);
         }
         strcpy(modelsav,stra);  
         /*printf("a=%s b=%s sav=%s\n", stra,strb,modelsav);
           scanf("%d",i);*/
       } /* end of loop + */
     } /* end model */
     
     /*The number n of Vn is stored in Tvar. cptcovage =number of age covariate. Tage gives the position of age. cptcovprod= number of products.
       If model=V1+V1*age then Tvar[1]=1 Tvar[2]=1 cptcovage=1 Tage[1]=2 cptcovprod=0*/
   
     /* printf("tvar1=%d tvar2=%d tvar3=%d cptcovage=%d Tage=%d",Tvar[1],Tvar[2],Tvar[3],cptcovage,Tage[1]);
     printf("cptcovprod=%d ", cptcovprod);
     fprintf(ficlog,"cptcovprod=%d ", cptcovprod);
   
     scanf("%d ",i);*/
   
       /*  if(mle==1){*/
     if (weightopt != 1) { /* Maximisation without weights*/
       for(i=1;i<=n;i++) weight[i]=1.0;
     }
       /*-calculation of age at interview from date of interview and age at death -*/
     agev=matrix(1,maxwav,1,imx);
   
     for (i=1; i<=imx; i++) {
       for(m=2; (m<= maxwav); m++) {
         if (((int)mint[m][i]== 99) && (s[m][i] <= nlstate)){
           anint[m][i]=9999;
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]==9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           fprintf(ficlog,"Error! Date of death (month %2d and year %4d) of individual %ld on line %d was unknown, you must set an arbitrary year of death or he/she is skipped and results are biased\n",(int)moisdc[i],(int)andc[i],num[i],i);
           s[m][i]=-1;
         }
         if((int)moisdc[i]==99 && (int)andc[i]!=9999 && s[m][i]>nlstate){
           nberr++;
           printf("Error! Month of death of individual %ld on line %d was unknown %2d, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,(int)moisdc[i]); 
           fprintf(ficlog,"Error! Month of death of individual %ld on line %d was unknown %f, you should set it otherwise the information on the death is skipped and results are biased.\n",num[i],i,moisdc[i]); 
           s[m][i]=-1; /* We prefer to skip it (and to skip it in version 0.8a1 too */
         }
       }
     }
   
     for (i=1; i<=imx; i++)  {
       agedc[i]=(moisdc[i]/12.+andc[i])-(moisnais[i]/12.+annais[i]);
       for(m=firstpass; (m<= lastpass); m++){
         if(s[m][i] >0 || s[m][i]==-2 || s[m][i]==-4 || s[m][i]==-5){
           if (s[m][i] >= nlstate+1) {
             if(agedc[i]>0)
               if((int)moisdc[i]!=99 && (int)andc[i]!=9999)
                 agev[m][i]=agedc[i];
             /*if(moisdc[i]==99 && andc[i]==9999) s[m][i]=-1;*/
               else {
                 if ((int)andc[i]!=9999){
                   nbwarn++;
                   printf("Warning negative age at death: %ld line:%d\n",num[i],i);
                   fprintf(ficlog,"Warning negative age at death: %ld line:%d\n",num[i],i);
                   agev[m][i]=-1;
                 }
               }
           }
           else if(s[m][i] !=9){ /* Standard case, age in fractional
                                    years but with the precision of a month */
             agev[m][i]=(mint[m][i]/12.+1./24.+anint[m][i])-(moisnais[i]/12.+1./24.+annais[i]);
             if((int)mint[m][i]==99 || (int)anint[m][i]==9999)
               agev[m][i]=1;
             else if(agev[m][i] <agemin){ 
               agemin=agev[m][i];
               /*printf(" Min anint[%d][%d]=%.2f annais[%d]=%.2f, agemin=%.2f\n",m,i,anint[m][i], i,annais[i], agemin);*/
             }
             else if(agev[m][i] >agemax){
               agemax=agev[m][i];
               /* printf(" anint[%d][%d]=%.0f annais[%d]=%.0f, agemax=%.0f\n",m,i,anint[m][i], i,annais[i], agemax);*/
             }
             /*agev[m][i]=anint[m][i]-annais[i];*/
             /*     agev[m][i] = age[i]+2*m;*/
           }
           else { /* =9 */
             agev[m][i]=1;
             s[m][i]=-1;
           }
         }
         else /*= 0 Unknown */
           agev[m][i]=1;
       }
       
     }
     for (i=1; i<=imx; i++)  {
       for(m=firstpass; (m<=lastpass); m++){
         if (s[m][i] > (nlstate+ndeath)) {
           nberr++;
           printf("Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           fprintf(ficlog,"Error: on wave %d of individual %d status %d > (nlstate+ndeath)=(%d+%d)=%d\n",m,i,s[m][i],nlstate, ndeath, nlstate+ndeath);     
           goto end;
         }
       }
     }
   
     /*for (i=1; i<=imx; i++){
     for (m=firstpass; (m<lastpass); m++){
        printf("%ld %d %.lf %d %d\n", num[i],(covar[1][i]),agev[m][i],s[m][i],s[m+1][i]);
   }
   
   }*/
   
   
     printf("Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax);
     fprintf(ficlog,"Total number of individuals= %d, Agemin = %.2f, Agemax= %.2f\n\n", imx, agemin, agemax); 
   
     agegomp=(int)agemin;
     free_vector(severity,1,maxwav);
     free_imatrix(outcome,1,maxwav+1,1,n);
     free_vector(moisnais,1,n);
     free_vector(annais,1,n);
     /* free_matrix(mint,1,maxwav,1,n);
        free_matrix(anint,1,maxwav,1,n);*/
     free_vector(moisdc,1,n);
     free_vector(andc,1,n);
   
      
     wav=ivector(1,imx);
     dh=imatrix(1,lastpass-firstpass+1,1,imx);
     bh=imatrix(1,lastpass-firstpass+1,1,imx);
     mw=imatrix(1,lastpass-firstpass+1,1,imx);
      
     /* Concatenates waves */
     concatwav(wav, dh, bh, mw, s, agedc, agev,  firstpass, lastpass, imx, nlstate, stepm);
   
     /* Routine tricode is to calculate cptcoveff (real number of unique covariates) and to associate covariable number and modality */
   
     Tcode=ivector(1,100);
     nbcode=imatrix(0,NCOVMAX,0,NCOVMAX); 
     ncodemax[1]=1;
     if (cptcovn > 0) tricode(Tvar,nbcode,imx);
         
     codtab=imatrix(1,100,1,10); /* Cross tabulation to get the order of 
                                    the estimations*/
     h=0;
     m=pow(2,cptcoveff);
    
     for(k=1;k<=cptcoveff; k++){
       for(i=1; i <=(m/pow(2,k));i++){
         for(j=1; j <= ncodemax[k]; j++){
           for(cpt=1; cpt <=(m/pow(2,cptcoveff+1-k)); cpt++){
             h++;
             if (h>m) h=1;codtab[h][k]=j;codtab[h][Tvar[k]]=j;
             /*  printf("h=%d k=%d j=%d codtab[h][k]=%d tvar[k]=%d \n",h, k,j,codtab[h][k],Tvar[k]);*/
           } 
         }
       }
     } 
     /* printf("codtab[1][2]=%d codtab[2][2]=%d",codtab[1][2],codtab[2][2]); 
        codtab[1][2]=1;codtab[2][2]=2; */
     /* for(i=1; i <=m ;i++){ 
        for(k=1; k <=cptcovn; k++){
        printf("i=%d k=%d %d %d ",i,k,codtab[i][k], cptcoveff);
        }
        printf("\n");
        }
        scanf("%d",i);*/
       
     /*------------ gnuplot -------------*/
     strcpy(optionfilegnuplot,optionfilefiname);
     if(mle==-3)
       strcat(optionfilegnuplot,"-mort");
     strcat(optionfilegnuplot,".gp");
   
     if((ficgp=fopen(optionfilegnuplot,"w"))==NULL) {
       printf("Problem with file %s",optionfilegnuplot);
     }
     else{
       fprintf(ficgp,"\n# %s\n", version); 
       fprintf(ficgp,"# %s\n", optionfilegnuplot); 
       fprintf(ficgp,"set missing 'NaNq'\n");
     }
     /*  fclose(ficgp);*/
     /*--------- index.htm --------*/
   
     strcpy(optionfilehtm,optionfilefiname); /* Main html file */
     if(mle==-3)
       strcat(optionfilehtm,"-mort");
     strcat(optionfilehtm,".htm");
     if((fichtm=fopen(optionfilehtm,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtm), exit(0);
     }
   
     strcpy(optionfilehtmcov,optionfilefiname); /* Only for matrix of covariance */
     strcat(optionfilehtmcov,"-cov.htm");
     if((fichtmcov=fopen(optionfilehtmcov,"w"))==NULL)    {
       printf("Problem with %s \n",optionfilehtmcov), exit(0);
     }
     else{
     fprintf(fichtmcov,"<body>\n<title>IMaCh Cov %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model);
     }
   
     fprintf(fichtm,"<body>\n<title>IMaCh %s</title>\n <font size=\"2\">%s <br> %s</font> \
   <hr size=\"2\" color=\"#EC5E5E\"> \n\
   Title=%s <br>Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=%s<br>\n\
   \n\
   <hr  size=\"2\" color=\"#EC5E5E\">\
    <ul><li><h4>Parameter files</h4>\n\
    - Parameter file: <a href=\"%s.%s\">%s.%s</a><br>\n\
    - Copy of the parameter file: <a href=\"o%s\">o%s</a><br>\n\
    - Log file of the run: <a href=\"%s\">%s</a><br>\n\
    - Gnuplot file name: <a href=\"%s\">%s</a><br>\n\
    - Date and time at start: %s</ul>\n",\
             fileres,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model,\
             optionfilefiname,optionfilext,optionfilefiname,optionfilext,\
             fileres,fileres,\
             filelog,filelog,optionfilegnuplot,optionfilegnuplot,strstart);
     fflush(fichtm);
   
     strcpy(pathr,path);
     strcat(pathr,optionfilefiname);
     chdir(optionfilefiname); /* Move to directory named optionfile */
     
     /* Calculates basic frequencies. Computes observed prevalence at single age
        and prints on file fileres'p'. */
     freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint,strstart);
   
     fprintf(fichtm,"\n");
     fprintf(fichtm,"<br>Total number of observations=%d <br>\n\
   Youngest age at first (selected) pass %.2f, oldest age %.2f<br>\n\
   Interval (in months) between two waves: Min=%d Max=%d Mean=%.2lf<br>\n",\
             imx,agemin,agemax,jmin,jmax,jmean);
     pmmij= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       newms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       savms= matrix(1,nlstate+ndeath,1,nlstate+ndeath); /* creation */
       oldm=oldms; newm=newms; savm=savms; /* Keeps fixed addresses to free */
       
      
     /* For Powell, parameters are in a vector p[] starting at p[1]
        so we point p on param[1][1] so that p[1] maps on param[1][1][1] */
     p=param[1][1]; /* *(*(*(param +1)+1)+0) */
   
     globpr=0; /* To get the number ipmx of contributions and the sum of weights*/
   
     if (mle==-3){
       ximort=matrix(1,NDIM,1,NDIM);
       cens=ivector(1,n);
       ageexmed=vector(1,n);
       agecens=vector(1,n);
       dcwave=ivector(1,n);
    
       for (i=1; i<=imx; i++){
         dcwave[i]=-1;
         for (m=firstpass; m<=lastpass; m++)
           if (s[m][i]>nlstate) {
             dcwave[i]=m;
             /*    printf("i=%d j=%d s=%d dcwave=%d\n",i,j, s[j][i],dcwave[i]);*/
             break;
           }
       }
   
       for (i=1; i<=imx; i++) {
         if (wav[i]>0){
           ageexmed[i]=agev[mw[1][i]][i];
           j=wav[i];
           agecens[i]=1.; 
   
           if (ageexmed[i]> 1 && wav[i] > 0){
             agecens[i]=agev[mw[j][i]][i];
             cens[i]= 1;
           }else if (ageexmed[i]< 1) 
             cens[i]= -1;
           if (agedc[i]< AGESUP && agedc[i]>1 && dcwave[i]>firstpass && dcwave[i]<=lastpass)
             cens[i]=0 ;
         }
         else cens[i]=-1;
       }
       
       for (i=1;i<=NDIM;i++) {
         for (j=1;j<=NDIM;j++)
           ximort[i][j]=(i == j ? 1.0 : 0.0);
       }
       
       p[1]=0.0268; p[NDIM]=0.083;
       /*printf("%lf %lf", p[1], p[2]);*/
       
       
       printf("Powell\n");  fprintf(ficlog,"Powell\n");
       strcpy(filerespow,"pow-mort"); 
       strcat(filerespow,fileres);
       if((ficrespow=fopen(filerespow,"w"))==NULL) {
         printf("Problem with resultfile: %s\n", filerespow);
         fprintf(ficlog,"Problem with resultfile: %s\n", filerespow);
       }
       fprintf(ficrespow,"# Powell\n# iter -2*LL");
       /*  for (i=1;i<=nlstate;i++)
           for(j=1;j<=nlstate+ndeath;j++)
           if(j!=i)fprintf(ficrespow," p%1d%1d",i,j);
       */
       fprintf(ficrespow,"\n");
       
       powell(p,ximort,NDIM,ftol,&iter,&fret,gompertz);
       fclose(ficrespow);
       
       hesscov(matcov, p, NDIM, delti, 1e-4, gompertz); 
   
       for(i=1; i <=NDIM; i++)
         for(j=i+1;j<=NDIM;j++)
           matcov[i][j]=matcov[j][i];
       
       printf("\nCovariance matrix\n ");
       for(i=1; i <=NDIM; i++) {
         for(j=1;j<=NDIM;j++){ 
           printf("%f ",matcov[i][j]);
         }
         printf("\n ");
       }
       
       printf("iter=%d MLE=%f Eq=%lf*exp(%lf*(age-%d))\n",iter,-gompertz(p),p[1],p[2],agegomp);
       for (i=1;i<=NDIM;i++) 
         printf("%f [%f ; %f]\n",p[i],p[i]-2*sqrt(matcov[i][i]),p[i]+2*sqrt(matcov[i][i]));
   
       lsurv=vector(1,AGESUP);
       lpop=vector(1,AGESUP);
       tpop=vector(1,AGESUP);
       lsurv[agegomp]=100000;
       
       for (k=agegomp;k<=AGESUP;k++) {
         agemortsup=k;
         if (p[1]*exp(p[2]*(k-agegomp))>1) break;
       }
       
       for (k=agegomp;k<agemortsup;k++)
         lsurv[k+1]=lsurv[k]-lsurv[k]*(p[1]*exp(p[2]*(k-agegomp)));
       
       for (k=agegomp;k<agemortsup;k++){
         lpop[k]=(lsurv[k]+lsurv[k+1])/2.;
         sumlpop=sumlpop+lpop[k];
       }
       
       tpop[agegomp]=sumlpop;
       for (k=agegomp;k<(agemortsup-3);k++){
         /*  tpop[k+1]=2;*/
         tpop[k+1]=tpop[k]-lpop[k];
       }
       
       
       printf("\nAge   lx     qx    dx    Lx     Tx     e(x)\n");
       for (k=agegomp;k<(agemortsup-2);k++) 
         printf("%d %.0lf %lf %.0lf %.0lf %.0lf %lf\n",k,lsurv[k],p[1]*exp(p[2]*(k-agegomp)),(p[1]*exp(p[2]*(k-agegomp)))*lsurv[k],lpop[k],tpop[k],tpop[k]/lsurv[k]);
       
       
       replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
       printinggnuplotmort(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtmlmort(fileres,title,datafile, firstpass, lastpass, \
                        stepm, weightopt,\
                        model,imx,p,matcov,agemortsup);
       
       free_vector(lsurv,1,AGESUP);
       free_vector(lpop,1,AGESUP);
       free_vector(tpop,1,AGESUP);
     } /* Endof if mle==-3 */
     
     else{ /* For mle >=1 */
     
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("First Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       globpr=1; /* to print the contributions */
       likelione(ficres, p, npar, nlstate, &globpr, &ipmx, &sw, &fretone, funcone); /* Prints the contributions to the likelihood */
       printf("Second Likeli=%12.6f ipmx=%ld sw=%12.6f",fretone,ipmx,sw);
       for (k=1; k<=npar;k++)
         printf(" %d %8.5f",k,p[k]);
       printf("\n");
       if(mle>=1){ /* Could be 1 or 2 */
         mlikeli(ficres,p, npar, ncovmodel, nlstate, ftol, func);
       }
       
       /*--------- results files --------------*/
       fprintf(ficres,"title=%s datafile=%s lastobs=%d firstpass=%d lastpass=%d\nftol=%e stepm=%d ncovcol=%d nlstate=%d ndeath=%d maxwav=%d mle= 0 weight=%d\nmodel=%s\n", title, datafile, lastobs, firstpass,lastpass,ftol, stepm, ncovcol, nlstate, ndeath, maxwav, weightopt,model);
       
       
       fprintf(ficres,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       printf("# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       fprintf(ficlog,"# Parameters nlstate*nlstate*ncov a12*1 + b12 * age + ...\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(k=1; k <=(nlstate+ndeath); k++){
           if (k != i) {
             printf("%d%d ",i,k);
             fprintf(ficlog,"%d%d ",i,k);
             fprintf(ficres,"%1d%1d ",i,k);
             for(j=1; j <=ncovmodel; j++){
               printf("%f ",p[jk]);
               fprintf(ficlog,"%f ",p[jk]);
               fprintf(ficres,"%f ",p[jk]);
               jk++; 
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       if(mle!=0){
         /* Computing hessian and covariance matrix */
         ftolhess=ftol; /* Usually correct */
         hesscov(matcov, p, npar, delti, ftolhess, func);
       }
       fprintf(ficres,"# Scales (for hessian or gradient estimation)\n");
       printf("# Scales (for hessian or gradient estimation)\n");
       fprintf(ficlog,"# Scales (for hessian or gradient estimation)\n");
       for(i=1,jk=1; i <=nlstate; i++){
         for(j=1; j <=nlstate+ndeath; j++){
           if (j!=i) {
             fprintf(ficres,"%1d%1d",i,j);
             printf("%1d%1d",i,j);
             fprintf(ficlog,"%1d%1d",i,j);
             for(k=1; k<=ncovmodel;k++){
               printf(" %.5e",delti[jk]);
               fprintf(ficlog," %.5e",delti[jk]);
               fprintf(ficres," %.5e",delti[jk]);
               jk++;
             }
             printf("\n");
             fprintf(ficlog,"\n");
             fprintf(ficres,"\n");
           }
         }
       }
       
       fprintf(ficres,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       if(mle>=1)
         printf("# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       fprintf(ficlog,"# Covariance matrix \n# 121 Var(a12)\n# 122 Cov(b12,a12) Var(b12)\n#   ...\n# 232 Cov(b23,a12)  Cov(b23,b12) ... Var (b23)\n");
       /* # 121 Var(a12)\n\ */
       /* # 122 Cov(b12,a12) Var(b12)\n\ */
       /* # 131 Cov(a13,a12) Cov(a13,b12, Var(a13)\n\ */
       /* # 132 Cov(b13,a12) Cov(b13,b12, Cov(b13,a13) Var(b13)\n\ */
       /* # 212 Cov(a21,a12) Cov(a21,b12, Cov(a21,a13) Cov(a21,b13) Var(a21)\n\ */
       /* # 212 Cov(b21,a12) Cov(b21,b12, Cov(b21,a13) Cov(b21,b13) Cov(b21,a21) Var(b21)\n\ */
       /* # 232 Cov(a23,a12) Cov(a23,b12, Cov(a23,a13) Cov(a23,b13) Cov(a23,a21) Cov(a23,b21) Var(a23)\n\ */
       /* # 232 Cov(b23,a12) Cov(b23,b12) ... Var (b23)\n" */
       
       
       /* Just to have a covariance matrix which will be more understandable
          even is we still don't want to manage dictionary of variables
       */
       for(itimes=1;itimes<=2;itimes++){
         jj=0;
         for(i=1; i <=nlstate; i++){
           for(j=1; j <=nlstate+ndeath; j++){
             if(j==i) continue;
             for(k=1; k<=ncovmodel;k++){
               jj++;
               ca[0]= k+'a'-1;ca[1]='\0';
               if(itimes==1){
                 if(mle>=1)
                   printf("#%1d%1d%d",i,j,k);
                 fprintf(ficlog,"#%1d%1d%d",i,j,k);
                 fprintf(ficres,"#%1d%1d%d",i,j,k);
               }else{
                 if(mle>=1)
                   printf("%1d%1d%d",i,j,k);
                 fprintf(ficlog,"%1d%1d%d",i,j,k);
                 fprintf(ficres,"%1d%1d%d",i,j,k);
               }
               ll=0;
               for(li=1;li <=nlstate; li++){
                 for(lj=1;lj <=nlstate+ndeath; lj++){
                   if(lj==li) continue;
                   for(lk=1;lk<=ncovmodel;lk++){
                     ll++;
                     if(ll<=jj){
                       cb[0]= lk +'a'-1;cb[1]='\0';
                       if(ll<jj){
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficlog," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                           fprintf(ficres," Cov(%s%1d%1d,%s%1d%1d)",ca,i,j,cb, li,lj);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }else{
                         if(itimes==1){
                           if(mle>=1)
                             printf(" Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficlog," Var(%s%1d%1d)",ca,i,j);
                           fprintf(ficres," Var(%s%1d%1d)",ca,i,j);
                         }else{
                           if(mle>=1)
                             printf(" %.5e",matcov[jj][ll]); 
                           fprintf(ficlog," %.5e",matcov[jj][ll]); 
                           fprintf(ficres," %.5e",matcov[jj][ll]); 
                         }
                       }
                     }
                   } /* end lk */
                 } /* end lj */
               } /* end li */
               if(mle>=1)
                 printf("\n");
               fprintf(ficlog,"\n");
               fprintf(ficres,"\n");
               numlinepar++;
             } /* end k*/
           } /*end j */
         } /* end i */
       } /* end itimes */
       
       fflush(ficlog);
       fflush(ficres);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       estepm=0;
       fscanf(ficpar,"agemin=%lf agemax=%lf bage=%lf fage=%lf estepm=%d\n",&ageminpar,&agemaxpar, &bage, &fage, &estepm);
       if (estepm==0 || estepm < stepm) estepm=stepm;
       if (fage <= 2) {
         bage = ageminpar;
         fage = agemaxpar;
       }
       
       fprintf(ficres,"# agemin agemax for life expectancy, bage fage (if mle==0 ie no data nor Max likelihood).\n");
       fprintf(ficres,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       fprintf(ficparo,"agemin=%.0f agemax=%.0f bage=%.0f fage=%.0f estepm=%d\n",ageminpar,agemaxpar,bage,fage, estepm);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"begin-prev-date=%lf/%lf/%lf end-prev-date=%lf/%lf/%lf mov_average=%d\n",&jprev1, &mprev1,&anprev1,&jprev2, &mprev2,&anprev2,&mobilav);
       fprintf(ficparo,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficres,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       printf("begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       fprintf(ficlog,"begin-prev-date=%.lf/%.lf/%.lf end-prev-date=%.lf/%.lf/%.lf mov_average=%d\n",jprev1, mprev1,anprev1,jprev2, mprev2,anprev2,mobilav);
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       
       dateprev1=anprev1+(mprev1-1)/12.+(jprev1-1)/365.;
       dateprev2=anprev2+(mprev2-1)/12.+(jprev2-1)/365.;
       
       fscanf(ficpar,"pop_based=%d\n",&popbased);
       fprintf(ficparo,"pop_based=%d\n",popbased);   
       fprintf(ficres,"pop_based=%d\n",popbased);   
       
       while((c=getc(ficpar))=='#' && c!= EOF){
         ungetc(c,ficpar);
         fgets(line, MAXLINE, ficpar);
         puts(line);
         fputs(line,ficparo);
       }
       ungetc(c,ficpar);
       
       fscanf(ficpar,"prevforecast=%d starting-proj-date=%lf/%lf/%lf final-proj-date=%lf/%lf/%lf mobil_average=%d\n",&prevfcast,&jproj1,&mproj1,&anproj1,&jproj2,&mproj2,&anproj2,&mobilavproj);
       fprintf(ficparo,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       printf("prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficlog,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       fprintf(ficres,"prevforecast=%d starting-proj-date=%.lf/%.lf/%.lf final-proj-date=%.lf/%.lf/%.lf mobil_average=%d\n",prevfcast,jproj1,mproj1,anproj1,jproj2,mproj2,anproj2,mobilavproj);
       /* day and month of proj2 are not used but only year anproj2.*/
       
       
       
       /*  freqsummary(fileres, agemin, agemax, s, agev, nlstate, imx,Tvaraff,nbcode, ncodemax,mint,anint);*/
       /*,dateprev1,dateprev2,jprev1, mprev1,anprev1,jprev2, mprev2,anprev2);*/
       
       replace_back_to_slash(pathc,path); /* Even gnuplot wants a / */
       printinggnuplot(fileres, optionfilefiname,ageminpar,agemaxpar,fage, pathc,p);
       
       printinghtml(fileres,title,datafile, firstpass, lastpass, stepm, weightopt,\
                    model,imx,jmin,jmax,jmean,rfileres,popforecast,estepm,\
                    jprev1,mprev1,anprev1,jprev2,mprev2,anprev2);
         
      /*------------ free_vector  -------------*/
      /*  chdir(path); */
    
       free_ivector(wav,1,imx);
       free_imatrix(dh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(bh,1,lastpass-firstpass+1,1,imx);
       free_imatrix(mw,1,lastpass-firstpass+1,1,imx);   
       free_lvector(num,1,n);
       free_vector(agedc,1,n);
       /*free_matrix(covar,0,NCOVMAX,1,n);*/
       /*free_matrix(covar,1,NCOVMAX,1,n);*/
       fclose(ficparo);
       fclose(ficres);
   
   
       /*--------------- Prevalence limit  (period or stable prevalence) --------------*/
     
       strcpy(filerespl,"pl");
       strcat(filerespl,fileres);
       if((ficrespl=fopen(filerespl,"w"))==NULL) {
         printf("Problem with period (stable) prevalence resultfile: %s\n", filerespl);goto end;
         fprintf(ficlog,"Problem with period (stable) prevalence resultfile: %s\n", filerespl);goto end;
       }
       printf("Computing period (stable) prevalence: result on file '%s' \n", filerespl);
       fprintf(ficlog,"Computing period (stable) prevalence: result on file '%s' \n", filerespl);
       pstamp(ficrespl);
       fprintf(ficrespl,"# Period (stable) prevalence \n");
       fprintf(ficrespl,"#Age ");
       for(i=1; i<=nlstate;i++) fprintf(ficrespl,"%d-%d ",i,i);
       fprintf(ficrespl,"\n");
     
       prlim=matrix(1,nlstate,1,nlstate);
   
       agebase=ageminpar;
       agelim=agemaxpar;
       ftolpl=1.e-10;
       i1=cptcoveff;
       if (cptcovn < 1){i1=1;}
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           /*printf("cptcov=%d cptcod=%d codtab=%d nbcode=%d\n",cptcov, cptcod,Tcode[cptcode],codtab[cptcod][cptcov]);*/
           fprintf(ficrespl,"\n#******");
           printf("\n#******");
           fprintf(ficlog,"\n#******");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficrespl," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             printf(" V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficlog," V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficrespl,"******\n");
           printf("******\n");
           fprintf(ficlog,"******\n");
           
           for (age=agebase; age<=agelim; age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             fprintf(ficrespl,"%.0f ",age );
             for(j=1;j<=cptcoveff;j++)
               fprintf(ficrespl,"%d %d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             for(i=1; i<=nlstate;i++)
               fprintf(ficrespl," %.5f", prlim[i][i]);
             fprintf(ficrespl,"\n");
           }
         }
       }
       fclose(ficrespl);
   
       /*------------- h Pij x at various ages ------------*/
     
       strcpy(filerespij,"pij");  strcat(filerespij,fileres);
       if((ficrespij=fopen(filerespij,"w"))==NULL) {
         printf("Problem with Pij resultfile: %s\n", filerespij);goto end;
         fprintf(ficlog,"Problem with Pij resultfile: %s\n", filerespij);goto end;
       }
       printf("Computing pij: result on file '%s' \n", filerespij);
       fprintf(ficlog,"Computing pij: result on file '%s' \n", filerespij);
     
       stepsize=(int) (stepm+YEARM-1)/YEARM;
       /*if (stepm<=24) stepsize=2;*/
   
       agelim=AGESUP;
       hstepm=stepsize*YEARM; /* Every year of age */
       hstepm=hstepm/stepm; /* Typically 2 years, = 2/6 months = 4 */ 
   
       /* hstepm=1;   aff par mois*/
       pstamp(ficrespij);
       fprintf(ficrespij,"#****** h Pij x Probability to be in state j at age x+h being in i at x ");
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficrespij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrespij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrespij,"******\n");
           
           for (agedeb=fage; agedeb>=bage; agedeb--){ /* If stepm=6 months */
             nhstepm=(int) rint((agelim-agedeb)*YEARM/stepm); /* Typically 20 years = 20*12/6=40 */ 
             nhstepm = nhstepm/hstepm; /* Typically 40/4=10 */
   
             /*      nhstepm=nhstepm*YEARM; aff par mois*/
   
             p3mat=ma3x(1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             oldm=oldms;savm=savms;
             hpxij(p3mat,nhstepm,agedeb,hstepm,p,nlstate,stepm,oldm,savm, k);  
             fprintf(ficrespij,"# Cov Agex agex+h hpijx with i,j=");
             for(i=1; i<=nlstate;i++)
               for(j=1; j<=nlstate+ndeath;j++)
                 fprintf(ficrespij," %1d-%1d",i,j);
             fprintf(ficrespij,"\n");
             for (h=0; h<=nhstepm; h++){
               fprintf(ficrespij,"%d %3.f %3.f",k,agedeb, agedeb+ h*hstepm/YEARM*stepm );
               for(i=1; i<=nlstate;i++)
                 for(j=1; j<=nlstate+ndeath;j++)
                   fprintf(ficrespij," %.5f", p3mat[i][j][h]);
               fprintf(ficrespij,"\n");
             }
             free_ma3x(p3mat,1,nlstate+ndeath,1, nlstate+ndeath, 0,nhstepm);
             fprintf(ficrespij,"\n");
           }
         }
       }
   
       varprob(optionfilefiname, matcov, p, delti, nlstate, bage, fage,k,Tvar,nbcode, ncodemax,strstart);
   
       fclose(ficrespij);
   
       probs= ma3x(1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
       for(i=1;i<=AGESUP;i++)
         for(j=1;j<=NCOVMAX;j++)
           for(k=1;k<=NCOVMAX;k++)
             probs[i][j][k]=0.;
   
       /*---------- Forecasting ------------------*/
       /*if((stepm == 1) && (strcmp(model,".")==0)){*/
       if(prevfcast==1){
         /*    if(stepm ==1){*/
         prevforecast(fileres, anproj1, mproj1, jproj1, agemin, agemax, dateprev1, dateprev2, mobilavproj, bage, fage, firstpass, lastpass, anproj2, p, cptcoveff);
         /* (popforecast==1) populforecast(fileres, anpyram,mpyram,jpyram, agemin,agemax, dateprev1, dateprev2,mobilav, agedeb, fage, popforecast, popfile, anpyram1,p, i1);*/
         /*      }  */
         /*      else{ */
         /*        erreur=108; */
         /*        printf("Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*        fprintf(ficlog,"Warning %d!! You can only forecast the prevalences if the optimization\n  has been performed with stepm = 1 (month) instead of %d or model=. instead of '%s'\n", erreur, stepm, model); */
         /*      } */
       }
     
   
       /*---------- Health expectancies and variances ------------*/
   
       strcpy(filerest,"t");
       strcat(filerest,fileres);
       if((ficrest=fopen(filerest,"w"))==NULL) {
         printf("Problem with total LE resultfile: %s\n", filerest);goto end;
         fprintf(ficlog,"Problem with total LE resultfile: %s\n", filerest);goto end;
       }
       printf("Computing Total Life expectancies with their standard errors: file '%s' \n", filerest); 
       fprintf(ficlog,"Computing Total Life expectancies with their standard errors: file '%s' \n", filerest); 
   
   
       strcpy(filerese,"e");
       strcat(filerese,fileres);
       if((ficreseij=fopen(filerese,"w"))==NULL) {
         printf("Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
         fprintf(ficlog,"Problem with Health Exp. resultfile: %s\n", filerese); exit(0);
       }
       printf("Computing Health Expectancies: result on file '%s' \n", filerese);
       fprintf(ficlog,"Computing Health Expectancies: result on file '%s' \n", filerese);
   
       strcpy(fileresstde,"stde");
       strcat(fileresstde,fileres);
       if((ficresstdeij=fopen(fileresstde,"w"))==NULL) {
         printf("Problem with Health Exp. and std errors resultfile: %s\n", fileresstde); exit(0);
         fprintf(ficlog,"Problem with Health Exp. and std errors resultfile: %s\n", fileresstde); exit(0);
       }
       printf("Computing Health Expectancies and standard errors: result on file '%s' \n", fileresstde);
       fprintf(ficlog,"Computing Health Expectancies and standard errors: result on file '%s' \n", fileresstde);
   
       strcpy(filerescve,"cve");
       strcat(filerescve,fileres);
       if((ficrescveij=fopen(filerescve,"w"))==NULL) {
         printf("Problem with Covar. Health Exp. resultfile: %s\n", filerescve); exit(0);
         fprintf(ficlog,"Problem with Covar. Health Exp. resultfile: %s\n", filerescve); exit(0);
       }
       printf("Computing Covar. of Health Expectancies: result on file '%s' \n", filerescve);
       fprintf(ficlog,"Computing Covar. of Health Expectancies: result on file '%s' \n", filerescve);
   
       strcpy(fileresv,"v");
       strcat(fileresv,fileres);
       if((ficresvij=fopen(fileresv,"w"))==NULL) {
         printf("Problem with variance resultfile: %s\n", fileresv);exit(0);
         fprintf(ficlog,"Problem with variance resultfile: %s\n", fileresv);exit(0);
       }
       printf("Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
       fprintf(ficlog,"Computing Variance-covariance of DFLEs: file '%s' \n", fileresv);
   
       /* Computes prevalence between agemin (i.e minimal age computed) and no more ageminpar */
       prevalence(probs, agemin, agemax, s, agev, nlstate, imx, Tvar, nbcode, ncodemax, mint, anint, dateprev1, dateprev2, firstpass, lastpass);
       /*  printf("ageminpar=%f, agemax=%f, s[lastpass][imx]=%d, agev[lastpass][imx]=%f, nlstate=%d, imx=%d,  mint[lastpass][imx]=%f, anint[lastpass][imx]=%f,dateprev1=%f, dateprev2=%f, firstpass=%d, lastpass=%d\n",\
           ageminpar, agemax, s[lastpass][imx], agev[lastpass][imx], nlstate, imx, mint[lastpass][imx],anint[lastpass][imx], dateprev1, dateprev2, firstpass, lastpass);
       */
   
       if (mobilav!=0) {
         mobaverage= ma3x(1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
         if (movingaverage(probs, bage, fage, mobaverage,mobilav)!=0){
           fprintf(ficlog," Error in movingaverage mobilav=%d\n",mobilav);
           printf(" Error in movingaverage mobilav=%d\n",mobilav);
         }
       }
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1; 
           fprintf(ficrest,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficrest,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficrest,"******\n");
   
           fprintf(ficreseij,"\n#****** ");
           fprintf(ficresstdeij,"\n#****** ");
           fprintf(ficrescveij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) {
             fprintf(ficreseij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficresstdeij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
             fprintf(ficrescveij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           }
           fprintf(ficreseij,"******\n");
           fprintf(ficresstdeij,"******\n");
           fprintf(ficrescveij,"******\n");
   
           fprintf(ficresvij,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvij,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvij,"******\n");
   
           eij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           evsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, strstart);  
           cvevsij(fileres, eij, p, nlstate, stepm, (int) bage, (int)fage, oldm, savm, k, estepm, delti, matcov, strstart);  
    
           vareij=ma3x(1,nlstate,1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,0, mobilav, strstart);
           if(popbased==1){
             varevsij(optionfilefiname, vareij, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k, estepm, cptcov,cptcod,popbased,mobilav, strstart);
           }
   
           pstamp(ficrest);
           fprintf(ficrest,"# Total life expectancy with std error and decomposition into time to be expected in each health state\n# Age ( e.. (std) ");
           for (i=1;i<=nlstate;i++) fprintf(ficrest,"e.%d (std) ",i);
           fprintf(ficrest,"\n");
   
           epj=vector(1,nlstate+1);
           for(age=bage; age <=fage ;age++){
             prevalim(prlim, nlstate, p, age, oldm, savm,ftolpl,k);
             if (popbased==1) {
               if(mobilav ==0){
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=probs[(int)age][i][k];
               }else{ /* mobilav */ 
                 for(i=1; i<=nlstate;i++)
                   prlim[i][i]=mobaverage[(int)age][i][k];
               }
             }
           
             fprintf(ficrest," %4.0f",age);
             for(j=1, epj[nlstate+1]=0.;j <=nlstate;j++){
               for(i=1, epj[j]=0.;i <=nlstate;i++) {
                 epj[j] += prlim[i][i]*eij[i][j][(int)age];
                 /*  printf("%lf %lf ", prlim[i][i] ,eij[i][j][(int)age]);*/
               }
               epj[nlstate+1] +=epj[j];
             }
   
             for(i=1, vepp=0.;i <=nlstate;i++)
               for(j=1;j <=nlstate;j++)
                 vepp += vareij[i][j][(int)age];
             fprintf(ficrest," %7.3f (%7.3f)", epj[nlstate+1],sqrt(vepp));
             for(j=1;j <=nlstate;j++){
               fprintf(ficrest," %7.3f (%7.3f)", epj[j],sqrt(vareij[j][j][(int)age]));
             }
             fprintf(ficrest,"\n");
           }
           free_ma3x(eij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_ma3x(vareij,1,nlstate,1,nlstate,(int) bage, (int)fage);
           free_vector(epj,1,nlstate+1);
         }
       }
       free_vector(weight,1,n);
       free_imatrix(Tvard,1,15,1,2);
       free_imatrix(s,1,maxwav+1,1,n);
       free_matrix(anint,1,maxwav,1,n); 
       free_matrix(mint,1,maxwav,1,n);
       free_ivector(cod,1,n);
       free_ivector(tab,1,NCOVMAX);
       fclose(ficreseij);
       fclose(ficresstdeij);
       fclose(ficrescveij);
       fclose(ficresvij);
       fclose(ficrest);
       fclose(ficpar);
     
       /*------- Variance of period (stable) prevalence------*/   
   
       strcpy(fileresvpl,"vpl");
       strcat(fileresvpl,fileres);
       if((ficresvpl=fopen(fileresvpl,"w"))==NULL) {
         printf("Problem with variance of period (stable) prevalence  resultfile: %s\n", fileresvpl);
         exit(0);
       }
       printf("Computing Variance-covariance of period (stable) prevalence: file '%s' \n", fileresvpl);
   
       for(cptcov=1,k=0;cptcov<=i1;cptcov++){
         for(cptcod=1;cptcod<=ncodemax[cptcov];cptcod++){
           k=k+1;
           fprintf(ficresvpl,"\n#****** ");
           for(j=1;j<=cptcoveff;j++) 
             fprintf(ficresvpl,"V%d=%d ",Tvaraff[j],nbcode[Tvaraff[j]][codtab[k][j]]);
           fprintf(ficresvpl,"******\n");
         
           varpl=matrix(1,nlstate,(int) bage, (int) fage);
           oldm=oldms;savm=savms;
           varprevlim(fileres, varpl, matcov, p, delti, nlstate, stepm, (int) bage, (int) fage, oldm, savm, prlim, ftolpl,k,strstart);
           free_matrix(varpl,1,nlstate,(int) bage, (int)fage);
         }
       }
   
       fclose(ficresvpl);
   
       /*---------- End : free ----------------*/
       if (mobilav!=0) free_ma3x(mobaverage,1, AGESUP,1,NCOVMAX, 1,NCOVMAX);
       free_ma3x(probs,1,AGESUP,1,NCOVMAX, 1,NCOVMAX);
   
     }  /* mle==-3 arrives here for freeing */
     free_matrix(prlim,1,nlstate,1,nlstate);
       free_matrix(pmmij,1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(oldms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(newms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(savms, 1,nlstate+ndeath,1,nlstate+ndeath);
       free_matrix(covar,0,NCOVMAX,1,n);
       free_matrix(matcov,1,npar,1,npar);
       /*free_vector(delti,1,npar);*/
       free_ma3x(delti3,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel); 
       free_matrix(agev,1,maxwav,1,imx);
       free_ma3x(param,1,nlstate,1, nlstate+ndeath-1,1,ncovmodel);
   
       free_ivector(ncodemax,1,8);
       free_ivector(Tvar,1,15);
       free_ivector(Tprod,1,15);
       free_ivector(Tvaraff,1,15);
       free_ivector(Tage,1,15);
       free_ivector(Tcode,1,100);
   
       free_imatrix(nbcode,0,NCOVMAX,0,NCOVMAX);
       free_imatrix(codtab,1,100,1,10);
     fflush(fichtm);
     fflush(ficgp);
     
   
     if((nberr >0) || (nbwarn>0)){
       printf("End of Imach with %d errors and/or %d warnings\n",nberr,nbwarn);
       fprintf(ficlog,"End of Imach with %d errors and/or warnings %d\n",nberr,nbwarn);
     }else{
       printf("End of Imach\n");
       fprintf(ficlog,"End of Imach\n");
     }
     printf("See log file on %s\n",filelog);
     /*  gettimeofday(&end_time, (struct timezone*)0);*/  /* after time */
     (void) gettimeofday(&end_time,&tzp);
     tm = *localtime(&end_time.tv_sec);
     tmg = *gmtime(&end_time.tv_sec);
     strcpy(strtend,asctime(&tm));
     printf("Local time at start %s\nLocal time at end   %s",strstart, strtend); 
     fprintf(ficlog,"Local time at start %s\nLocal time at end   %s\n",strstart, strtend); 
     printf("Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
   
     printf("Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     fprintf(ficlog,"Total time used %s\n", asc_diff_time(end_time.tv_sec -start_time.tv_sec,tmpout));
     fprintf(ficlog,"Total time was %d Sec.\n", end_time.tv_sec -start_time.tv_sec);
     /*  printf("Total time was %d uSec.\n", total_usecs);*/
   /*   if(fileappend(fichtm,optionfilehtm)){ */
     fprintf(fichtm,"<br>Local time at start %s<br>Local time at end   %s<br>",strstart, strtend);
     fclose(fichtm);
     fclose(fichtmcov);
     fclose(ficgp);
     fclose(ficlog);
     /*------ End -----------*/
   
     chdir(path);
     /*strcat(plotcmd,CHARSEPARATOR);*/
     sprintf(plotcmd,"gnuplot");
   #ifndef UNIX
     sprintf(plotcmd,"\"%sgnuplot.exe\"",pathimach);
   #endif
     if(!stat(plotcmd,&info)){
       printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
       if(!stat(getenv("GNUPLOTBIN"),&info)){
         printf("Error gnuplot program not found: %s Environment GNUPLOTBIN not set.\n",plotcmd);fflush(stdout);
       }else
         strcpy(pplotcmd,plotcmd);
   #ifdef UNIX
       strcpy(plotcmd,GNUPLOTPROGRAM);
       if(!stat(plotcmd,&info)){
         printf("Error gnuplot program not found: %s\n",plotcmd);fflush(stdout);
       }else
         strcpy(pplotcmd,plotcmd);
   #endif
     }else
       strcpy(pplotcmd,plotcmd);
     
     sprintf(plotcmd,"%s %s",pplotcmd, optionfilegnuplot);
     printf("Starting graphs with: %s\n",plotcmd);fflush(stdout);
   
     if((outcmd=system(plotcmd)) != 0){
       printf("\n Problem with gnuplot\n");
     }
     printf(" Wait...");
     while (z[0] != 'q') {
       /* chdir(path); */
       printf("\nType e to edit output files, g to graph again and q for exiting: ");
       scanf("%s",z);
   /*     if (z[0] == 'c') system("./imach"); */
       if (z[0] == 'e') {
         printf("Starting browser with: %s",optionfilehtm);fflush(stdout);
         system(optionfilehtm);
       }
       else if (z[0] == 'g') system(plotcmd);
       else if (z[0] == 'q') exit(0);
     }
     end:
     while (z[0] != 'q') {
       printf("\nType  q for exiting: ");
       scanf("%s",z);
     }
   }
   
   
   

Removed from v.1.7  
changed lines
  Added in v.1.118


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